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https://www.readbyqxmd.com/read/28441671/swimming-upstream-creating-a-culture-of-high-value-care
#1
Reshma Gupta, Christopher Moriates
As health system leaders strategize the best ways to encourage the transition toward value-based health care, the underlying culture-defined as a system of shared assumptions, values, beliefs, and norms existing within an environment-continues to shape clinician practice patterns. The current prevailing medical culture contributes to overtesting, overtreatment, and health care waste. Choosing Wisely lists, appropriateness criteria, and guidelines codify best practices, but academic medicine as a whole must recognize that faculty and trainees are all largely still operating within the same cultural climate...
May 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28441617/the-magic-survey-in-hormone-receptor-positive-hr-her2-negative-her2-breast-cancer-when-might-multigene-assays-be-of-value
#2
Matti Aapro, Michelino De Laurentiis, Dan Rea, Juan Enrique Bargallo Rocha, Roberto Elizalde, László Landherr, Barbro Linderholm, Eleftherios Mamounas, Christos Markopoulos, Patrick Neven, Alexander Petrovsky, Roman Rouzier, Vincent Smit, Christer Svedman, Daniel Schneider, Christoph Thomssen, Miguel Martin
BACKGROUND: A modest proportion of patients with early stage hormone receptor-positive (HR+), HER2-negative (HER2-) breast cancer benefit from adjuvant chemotherapy. Traditionally, treatment recommendations are based on clinical/pathologic criteria that are not predictive of chemotherapy benefit. Multigene assays provide prognostic and predictive information that can help to make more informed treatment decisions. The MAGIC survey evaluated international differences in treatment recommendations, how traditional parameters are used for making treatment choices, and for which patients treating physicians feel most uncertain about their decisions...
April 22, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28441556/death-receptor-6-promotes-wallerian-degeneration-in-peripheral-axons
#3
Kanchana K Gamage, Irene Cheng, Rachel E Park, Mardeen S Karim, Kazusa Edamura, Christopher Hughes, Anthony J Spano, Alev Erisir, Christopher D Deppmann
No abstract text is available yet for this article.
April 24, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28441498/thin-wall-gan-inaln-multiple-quantum-well-tubes
#4
Christophe Durand, Jean-François Carlin, Catherine Bougerol, Bruno Gayral, Damien Salomon, Jean-Paul Barnes, Joel Eymery, Raphael Butte, Nicolas Grandjean
Thin-wall tubes composed of nitride semiconductors (III-N compounds) based on GaN/InAlN multiple quantum wells (MQWs) are fabricated by metal-organic vapor-phase epitaxy in a simple and full III-N approach. The synthesis of such MQW-tubes is based on the growth of N-polar c-axis vertical GaN wires surrounded by a core-shell MQW heterostructure followed by in situ selective etching using controlled H2/NH3 annealing at 1010°C to remove the inner GaN wire part. After this process, well-defined MQW-based tubes having non-polar m-plane orientation exhibit UV light near 330 nm up to room temperature, consistent with the emission of GaN/InAlN MQWs...
April 25, 2017: Nano Letters
https://www.readbyqxmd.com/read/28441469/the-effect-of-ar-o-sub-2-sub-and-h-sub-2-sub-o-plasma-treatment-of-sno-sub-2-sub-nanoparticles-and-nanowires-on-carbon-monoxide-and-benzene-detection
#5
Erin P Stuckert, Christopher J Miller, Ellen R Fisher
As the final piece of a broader study on structure-property-performance of SnO<sub>2</sub> sensors, this study examines the performance of sensors created from tin (IV) oxide (SnO2) nanowires and nanoparticles as a function of temperature for untreated (UT) devices as well as those treated using Ar/O<sub>2</sub> and H<sub>2</sub>O plasmas. Nanoparticle and nanowire sensors were exposed to air, carbon monoxide (CO), or benzene (C<sub>6</sub>H<sub>6</sub>) to determine sensor response (R<sub>air</sub>/R<sub>gas</sub>) and sensitivity (R<sub>air</sub>/R</sub><sub>gas</sub> > 1 or R<sub>gas</sub>/R<sub>air</sub> > 1)...
April 25, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28441462/transcriptomic-profiling-of-a-chicken-lung-epithelial-cell-line-clec213-reveals-a-mitochondrial-respiratory-chain-activity-boost-during-influenza-virus-infection
#6
Léa Meyer, Olivier Leymarie, Christophe Chevalier, Evelyne Esnault, Marco Moroldo, Bruno Da Costa, Sonia Georgeault, Philippe Roingeard, Bernard Delmas, Pascale Quéré, Ronan Le Goffic
Avian Influenza virus (AIV) is a major concern for the global poultry industry. Since 2012, several countries have reported AIV outbreaks among domestic poultry. These outbreaks had tremendous impact on poultry production and socio-economic repercussion on farmers. In addition, the constant emergence of highly pathogenic AIV also poses a significant risk to human health. In this study, we used a chicken lung epithelial cell line (CLEC213) to gain a better understanding of the molecular consequences of low pathogenic AIV infection in their natural host...
2017: PloS One
https://www.readbyqxmd.com/read/28441415/pax7-remodels-the-chromatin-landscape-in-skeletal-muscle-stem-cells
#7
Karin C Lilja, Nan Zhang, Alessandro Magli, Volkan Gunduz, Christopher J Bowman, Robert W Arpke, Radbod Darabi, Michael Kyba, Rita Perlingeiro, Brian D Dynlacht
Pluripotent stem cells (PSC) hold great promise for the treatment of human skeletal muscle diseases. However, it remains challenging to convert PSC to skeletal muscle cells, and the mechanisms by which the master regulatory transcription factor, Pax7, promotes muscle stem (satellite) cell identity are not yet understood. We have taken advantage of PSC-derived skeletal muscle precursor cells (iPax7), wherein the induced expression of Pax7 robustly initiates the muscle program and enables the in vitro generation of precursors that seed the satellite cell compartment upon transplantation...
2017: PloS One
https://www.readbyqxmd.com/read/28441393/sequence-learning-modulates-neural-responses-and-oscillatory-coupling-in-human-and-monkey-auditory-cortex
#8
Yukiko Kikuchi, Adam Attaheri, Benjamin Wilson, Ariane E Rhone, Kirill V Nourski, Phillip E Gander, Christopher K Kovach, Hiroto Kawasaki, Timothy D Griffiths, Matthew A Howard, Christopher I Petkov
Learning complex ordering relationships between sensory events in a sequence is fundamental for animal perception and human communication. While it is known that rhythmic sensory events can entrain brain oscillations at different frequencies, how learning and prior experience with sequencing relationships affect neocortical oscillations and neuronal responses is poorly understood. We used an implicit sequence learning paradigm (an "artificial grammar") in which humans and monkeys were exposed to sequences of nonsense words with regularities in the ordering relationships between the words...
April 2017: PLoS Biology
https://www.readbyqxmd.com/read/28441369/cardiac-magnetic-resonance-imaging-in-oncology
#9
Daniel Jeong, Aarti Patel, Christopher J Francois, Kenneth L Gage, Michael G Fradley
BACKGROUND: Cardiac magnetic resonance imaging (MRI) is emerging as an important diagnostic modality in the management of cardiovascular-related dysfunction in oncological diseases. Advances in imaging techniques have enhanced the detection and evaluation of cardiac masses; meanwhile, innovative applications have created a growing role for cardiac MRI for the management of cardiotoxicity caused by cancer therapies. METHODS: An overview is provided of the clinical indications and technical considerations of cardiac MRI...
April 2017: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/28441308/factors-associated-with-the-development-of-and-revision-for-proximal-junctional-kyphosis-in-440-consecutive-adult-spinal-deformity-patients
#10
Fred H Nicholls, Junseok Bae, Alexander A Theologis, Murat S Eksi, Christopher P Ames, Sigurd H Berven, Shane Burch, Bobby K Tay, Vedat Deviren
STUDY DESIGN: Retrospective review of prospectively collected data OBJECTIVE.: The aim of this study was to examine which radiographic parameters and surgical strategies are most closely associated with proximal junctional kyphosis (PJK) after adult spinal deformity (ASD) surgery, the need for revision surgery for PJK, and whether these differ based on the upper instrumented vertebra (UIV). SUMMARY OF BACKGROUND DATA: Multiple parameters are considered when planning correction of ASD...
April 24, 2017: Spine
https://www.readbyqxmd.com/read/28441306/orientation-of-the-upper-most-instrumented-segment-influences-proximal-junctional-disease-following-adult-spinal-deformity-surgery
#11
Renaud Lafage, Breton G Line, Sachin Gupta, Barthelemy Liabaud, Frank Schwab, Justin S Smith, Jeffrey L Gum, Christopher P Ames, Richard Hostin, Gregory M Mundis, Han Jo Kim, Shay Bess, Eric Klineberg, Virginie Lafage
STUDY DESIGN: Retrospective review of a prospective database. OBJECTIVE: To define the role of sagittal orientation of the construct at the upper instrumented levels in the development of proximal junctional kyphosis (PJK) in adult spinal deformity (ASD) patients. SUMMARY OF BACKGROUND DATA: PJK following ASD surgery remains challenging. The final alignment of the upper instrumented vertebral segments has been proposed as a risk factor for PJK, but has not been fully investigated...
April 24, 2017: Spine
https://www.readbyqxmd.com/read/28441214/the-osteo-odonto-keratoprosthesis
#12
Mehran Zarei-Ghanavati, Venkata Avadhanam, Alfonso Vasquez Perez, Christopher Liu
PURPOSE OF REVIEW: To describe the practice of and recent developments in the osteo-odonto-keratoprosthesis. RECENT FINDINGS: Formal psychological assessment and support have been described. A sub-aqua system for fashioning the osteo-odonto-keratoprosthesis lamina; adoption of thicker laminae; use of bisphosphonate drugs; advances in laminar imaging; and use of bone augmentation and bone morphogenetic protein have been described for prevention, detection, and management of laminar resorption...
April 24, 2017: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/28441193/in-reply-to-willett
#13
Sara Bonnes, Thomas J Beckman, Christopher M Wittich
No abstract text is available yet for this article.
May 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28441074/assessing-lebanese-bilingual-children-the-use-of-cross-linguistic-lexical-tasks-in-lebanese-arabic
#14
Christel Khoury Aouad Saliby, Christophe Dos Santos, Edith Kouba Hreich, Camille Messarra
Since norms for vocabulary acquisition in Lebanese bilingual children (L1: Lebanese, L2: French and/or English) do not yet exist, clinical assessment based on normative data and using appropriate tools remains difficult for speech and language therapists. The current study focuses on exploring and comparing lexical performances of typically developing Lebanese bilingual children (32 Bi-TD, aged 5;7 to 6;9) and those with specific language impairment (10 Bi-SLI, aged 5;9 to 7;10), using cross-linguistic lexical tasks (LITMUS-CLT, COST Action IS0804, 2011) in Lebanese Arabic language (CLT-LB), specific to the Lebanese context...
April 25, 2017: Clinical Linguistics & Phonetics
https://www.readbyqxmd.com/read/28441051/diffusion-weighted-magnetic-resonance-imaging-of-the-brain-of-neurologically-normal-dogs
#15
Megan J MacLellan, Christopher P Ober, Daniel A Feeney, Carl R Jessen
OBJECTIVE To acquire MRI diffusion data (apparent diffusion coefficient [ADC] and fractional anisotropy [FA] values, including separate measures for gray and white matter) at 3.0 T for multiple locations of the brain of neurologically normal dogs. ANIMALS: 13 neurologically normal dogs recruited from a group of patients undergoing tibial plateau leveling osteotomy. PROCEDURES: MRI duration ranged from 20 to 30 minutes, including obtaining preliminary images to exclude pathological changes (T2-weighted fluid-attenuated inversion recovery transverse and dorsal images) and diffusion-weighted images...
May 2017: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/28441023/hydrophobic-nanoparticles-modify-the-thermal-release-behavior-of-liposomes
#16
Matthew Ryan Preiss, Ashley E Hart, Christopher L Kitchens, Geoffrey D Bothun
Understanding the effect of embedded nanoparticles on the characteristics and behavior of lipid bilayers is critical to the development of lipid-nanoparticle assemblies (LNAs) for biomedical applications. In this work we investigate the effect of hydrophobic nanoparticle size and concentration on liposomal thermal release behavior. Decorated LNAs (D-LNAs) were formed by embedding 2 nm (GNP2) and 4 nm (GNP4) dodecanethiol-capped gold nanoparticles into DPPC liposomes at lipid to nanoparticle ratios (L:N) of 25,000:1, 10,000:1, and 5,000:1...
April 25, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28440940/from-the-sea-to-the-laboratory-characterization-of-microplastic-as-prerequisite-for-the-assessment-of-ecotoxicological-impact
#17
Annegret Potthoff, Kathrin Oelschlägel, Mechthild Schmitt-Jansen, Christoph Daniel Rummel, Dana Kühnel
The presence of microplastic (MP) in the aquatic environment is recognized as a global-scale pollution issue. Secondary MP particles result from an ongoing fragmentation process governed by various biotic and abiotic factors. For a reliable risk assessment of these MP particles, knowledge about interactions with biota is needed. However, extensive testing with standard organisms under reproducible laboratory conditions with well-characterized MP suspensions is not available yet. As MP in the environment represents a mixture of particles differing in properties (e...
May 2017: Integrated Environmental Assessment and Management
https://www.readbyqxmd.com/read/28440922/pseudomonas-aeruginosa-and-post-tracheotomy-bacterial-respiratory-tract-infection-readmissions
#18
Christopher J Russell, Tamara D Simon, Mary R Mamey, Christopher J L Newth, Michael N Neely
OBJECTIVE: Identify risk factors for readmission due to a bacterial tracheostomy-associated respiratory tract infection (bTARTI) within 12 months of discharge after tracheotomy. DESIGN/METHODS: We performed a retrospective cohort study of 240 children who underwent tracheotomy and were discharged with tracheotsomy in place between January 1, 2005 and June 30, 2013. Children with prolonged total or post-tracheotomy length of stay (LOS), less than 12 months of follow-up, or who died during the index hospitalization were excluded...
April 25, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/28440855/accuracy-of-current-diagnostic-criteria-for-acute-bacterial-infection-in-older-adults-in-the-emergency-department
#19
Jeffrey M Caterino, Robert Leininger, David M Kline, Lauren T Southerland, Salman Khaliqdina, Christopher W Baugh, Daniel J Pallin, Kurt B Stevenson
OBJECTIVES: To compare the accuracy of the Loeb criteria, emergency department (ED) physicians' diagnoses, and Centers for Disease Control and Prevention (CDC) guidelines for acute bacterial infection in older adults with a criterion standard expert review. DESIGN: Prospective, observational study. SETTING: Urban, tertiary-care ED. PARTICIPANTS: Individuals aged 65 and older in the ED, excluding those who were incarcerated, underwent a trauma, did not speak English, or were unable to consent...
April 25, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28440740/biomarkers-and-bacteria-around-implants-and-natural-teeth-in-the-same-individuals
#20
Önder Gürlek, Pınar Gümüş, Christopher J Nile, David F Lappin, Nurcan Buduneli
AIM: This cross-sectional study assessed cytokine levels in peri-implant crevicular fluid (PICF)/ gingival crevicular fluid (GCF) and a selection of subgingival/submucosal plaque bacteria from clinically healthy or diseased sites in the same individuals. MATERIAL AND METHODS: Samples from 97 implants/teeth (58 implants: 19 healthy, 20 mucositis, 19 peri-implantitis; 39 natural teeth: 19 healthy, 12 gingivitis, 8 periodontitis) in 15 systemically healthy patients were investigated by immunoassay, real-time PCR...
April 25, 2017: Journal of Periodontology
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