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pheNytoin with LDL

Şükrü Beydemir, Yeliz Demir
Serum paraoxonase (PON1) is a key enzyme related to high-density lipoprotein (HDL)-cholesterol particle. It can prevent the oxidation of low-density lipoprotein (LDL) and HDL. The present article focuses on the in vitro inhibition role of some antiepileptic drugs (AEDs) such as valproic acid, gabapentin, primidone, phenytoin, and levetiracetam on human paraoxonase (hPON1). Therefore, PON1 was purified from human serum with a specific activity of 3976.36 EU/mg and 13.96% yield by using simple chromatographic methods...
June 2017: Journal of Biochemical and Molecular Toxicology
Ken Ikeda, Masahiro Sawada, Harumi Morioka, Maya Kyuzen, Junya Ebina, Junpei Nagasawa, Masaru Yanagihashi, Ken Miura, Yuichi Ishikawa, Takehisa Hirayama, Takanori Takazawa, Osamu Kano, Kiyokazu Kawabe, Yasuo Iwasaki
BACKGROUND: Antiepileptic drugs (AEDs) may increase development of dyslipidemia and cerebrovascular disease (CVD). We examined the clinical profile and changes of serum lipid levels after AED monotherapy in patients with poststroke epilepsy (PSE) after cerebral infarction (CI). SUBJECTS AND METHODS: Medical records were reviewed in consecutive 2144 CI patients. Monotherapy of valproate, carbamazepine (CBZ), phenytoin (PHT), zonisamide, levetiracetam, or lamotrigine was performed in PSE patients...
March 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
M I Lossius, K O Nakken, P Mowinckel, E Taubøll, L Gjerstad
OBJECTIVE: Patients treated with carbamazepine (CBZ) have increased serum levels of total cholesterol (TC), high-density lipoproteins (HDL), and low-density lipoproteins (LDL). We aimed to investigate whether these changes of serum lipids are reversible after CBZ withdrawal. MATERIAL AND METHODS: We used a prospective, randomized double-blinded design. A total of 160 patients who had been seizure free on anti-epileptic drug monotherapy for more than 2 years were included and randomized to withdrawal or not...
September 2016: Acta Neurologica Scandinavica
Manav V Vyas, Benjamin Andrew Davidson, Leonardo Escalaya, John Costella, Gustavo Saposnik, Jorge G Burneo
OBJECTIVE: To characterize the association between commonly used anti-epileptic drugs (AEDs) and plasma lipid levels in patients with epilepsy. METHODS: We sought observational studies that reported association between commonly used AEDs and plasma lipid levels in patients. The primary outcome was low-density lipoprotein (LDL) cholesterol. High-density lipoprotein (HDL), total cholesterol and triglyceride were secondary outcomes. The control group included healthy controls, pre-treatment patients or patients treated with other AEDs...
July 2015: Epilepsy Research
K Manimekalai, B Visakan, Kartik J Salwe, S Murugesan
INTRODUCTION: Several studies have reported that commonly used antiepileptic drugs like phenytoin, and carbamazepine increase serum High Density Lipoproteins Cholesterol (HDL-C) levels, while some others documented no such effect. Further, some researchers also observed that valproic acid and other newer antiepileptic drugs like lamotrigine and levetiracetam has no influence on serum lipid profile. The present study was planned to assess and compare serum lipid profile of young adult patients on commonly used antiepileptic drugs (phenytoin, oxcarbazepine and valproic acid) and newer antiepileptic drug (levetiracetam) attending Neurology OPD of a tertiary care hospital in Puducherry, India compared to normal subjects...
August 2014: Journal of Clinical and Diagnostic Research: JCDR
Naveen Sankhyan, Sheffali Gulati, Smriti Hari, Madhulika Kabra, Lakshmy Ramakrishnan, Veena Kalra
PURPOSE: This study was carried out to compare the carotid Intimal Media Thickness (IMT), and endothelial function using brachial flow mediated dilatation (FMD), in Epileptic children (6-12 years) on phenytoin (PHT) or carbamazepine (CBZ) monotherapy for ≥18 months with a control group of children. METHODS: In this cross-sectional study 30 children (aged 6-12 years) on PHT monotherapy and 28 children on CBZ monotherapy were compared with an equal number of apparently healthy age and sex matched children unexposed to antiepileptics...
November 2013: Epilepsy Research
Kanitpong Phabphal, Alan Geater, Kitti Limapichart, Pornchai Sathirapanya, Suwanna Setthawatcharawanich
PURPOSE: We investigated the influence of the CYP2C9 polymorphism on the lipid profile, insulin resistance, and subclinical atherosclerosis in young epileptic patients. METHODS: We performed a cross-sectional study to evaluate the association between CYP2C9 polymorphism and lipid profile, glucose homeostasis, and subclinical atherosclerosis in young epileptic patients via the ankle brachial index. RESULTS: The frequencies of CYP2C9*1 (CYP2C9 wild type gene) and CYP2C9*3 (CYP2C9 polymorphism gene) were 75% and 25%, respectively...
March 2013: Seizure: the Journal of the British Epilepsy Association
K Phabphal, K Limapichat, P Sathirapanya, S Setthawatcharawanich, A Geater
BACKGROUND AND PURPOSE: The most common prescribed antiepileptic drugs (AEDs), phenytoin and valproate, are potent enzyme inducers and inhibitors of the cytochrome P450 system, which interfere with lipid profile and glucose homeostasis. Studies on this topic have suffered from inadequate assessment of confounders and have rarely included glucose homeostasis and lipid profile as well as both enzyme inducers and inhibitors in the same study. We sought to determine whether these drugs had an effect on lipid profile and glucose homeostasis in Thai epileptic patients...
September 2012: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
Scott Mintzer, Christopher T Skidmore, Sara J Rankin, Inna Chervoneva, Edward Pequinot, David M Capuzzi, Michael R Sperling
PURPOSE: We previously demonstrated that converting patients from the enzyme-inducers phenytoin or carbamazepine to the non-inducers levetiracetam or lamotrigine reduces serum lipids and C-reactive protein (CRP). We sought to determine if the same changes would occur when patients were switched to topiramate, which has shown some evidence of enzyme induction at high doses. We also examined the effects of drug switch on low-density lipoprotein (LDL) particle concentration. METHODS: We converted 13 patients from phenytoin or carbamazepine monotherapy to topiramate monotherapy (most at doses of 100-150 mg/day)...
January 2012: Epilepsy Research
Sean D Candrilli, Ranjani Manjunath, Keith L Davis, Barry E Gidal
PURPOSE: Pharmacokinetic interactions have been demonstrated in enzyme-inducing antiepileptic drugs (EIAEDs) and statins; however, their clinical significance is not well established. The purpose of this study was to evaluate the association of EIAEDs and non-enzyme-inducing antiepileptic drugs (NEIAEDs) on statin dose adjustments and low-density lipoprotein (LDL) cholesterol levels in patients with epilepsy. METHODS: Retrospective insurance claims from 2000 to 2006 from the Ingenix Impact (formerly Integrated Health Care Information Services) database were analyzed...
October 2010: Epilepsy Research
Pooja Dewan, Anju Aggarwal, M M A Faridi
We conducted a case control study to evaluate the effect of phenytoin and valproic acid on serum lipids and liver function tests in epileptic children. Seventy-nine children receiving at least 6 months of antiepileptic monotherapy were categorized into two groups, depending on whether they were receiving phenytoin or valproic acid. Age matched healthy controls were also included. The mean total cholesterol (TC) in children on phenytoin therapy was significantly higher than the control group (P=0.03). Serum triglycerides, low density lipoprotein cholesterol, very low density lipoprotein cholesterol, and high density lipoprotein cholesterol, were not significantly different in the three groups...
October 2008: Indian Pediatrics
María J Tutor-Crespo, Jesús Hermida, J Carlos Tutor
The effect of enzyme-inducing anticonvulsant drugs on the serum concentrations of lipoproteins has been widely studied. However, there is little agreement between the results with regard to the possible development of a lipoprotein profile related to an increased or decreased cardiovascular risk. It has been suggested that cholinesterase (ChE) could be induced by these drugs, something of undeniable interest as ChE appears to have a relation to the metabolism of lipoproteins. The serum activity of ChE was determined in a group of 90 adult epileptic patients (56 male and 34 female) treated with phenobarbital, phenytoin, and carbamazepine...
September 2004: Journal of Clinical Pharmacology
Carme Trocho, Joan Carles Escolà-Gil, Vicent Ribas, Sònia Benítez, Jesús M Martín-Campos, Noemi Rotllan, Lourdes Osaba, Jordi Ordóñez-Llanos, Francesc González-Sastre, Francisco Blanco-Vaca
Phenytoin (PHT) increases high density lipoprotein cholesterol (HDL-C) and reduces coronary artery disease mortality in humans. We report the results of PHT treatment on atherosclerosis susceptibility and lipid profile in four different types of mouse: control C57BL/6 mice and cholesteryl ester transfer protein transgenic mice as models of fatty streak, and LDL receptor-deficient mice and apolipoprotein E-deficient mice as models of mature atherosclerosis. Each mouse type was fed an appropriate diet to induce atherosclerosis and prevent liver toxicity...
June 2004: Atherosclerosis
Triantafyllou Nikolaos, Gatzonis Stylianos, Nikolaou Chryssoula, Petropoulou Irini, Manolis Christos, Triantafyllou Dimitrios, Patsis Konstantinos, Tsagaropoulos Antonis
BACKGROUND: Antiepileptic drugs influence, among others, cholesterol and lipoprotein serum levels. MATERIAL/METHODS: Serum cholesterol (TC, HDL-c, and LDL-c) and triglyceride (TG) levels were measured in 103 epileptic patients receiving chronic antiepileptic monotherapy and in 103 age- and sex-matched controls. RESULTS: Compared with controls, patients on carbamazepine showed significant higher TC, HDL-c, and LDL-c and non significantly higher TG values...
April 2004: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
E Pita-Calandre, C M Rodríguez-López, M D Cano, M Peña-Bernal
INTRODUCTION: It is known that anticonvulsants are able to modify lipid profile; nevertheless the initial studies were performed in patients or polytherapy whereas later investigations were carried out mostly in children. OBJECTIVES: To evaluate serum lipids, lipoproteins and apolipoproteins in adult epileptic patients on monotherapy. MATERIAL AND METHODS: Total cholesterol, triglycerides, low- and high-density lipoprotein cholesterol (including the HDL2 and the HDL3 subfractions) and apolipoproteins A1 and B were measured in 120 epileptics patients treated with carbamazepine (n = 42), sodium valproate (n = 38) and phenytoin (n = 40) and compared with the values of 48 healthy subjects...
November 1998: Revista de Neurologia
M Miller, R G Burgan, L Osterlund, J P Segrest, D W Garber
Observational studies have demonstrated a positive association between phenytoin use and HDL cholesterol (HDL-C). Our goal was to determine whether phenytoin raises HDL-C in nonepileptic subjects at risk for coronary artery disease. We performed a double-blind, placebo-controlled, parallel-group study in 41 subjects with reduced levels of HDL-C. Subjects were placed on an American Heart Association Step I diet and were randomized to receive either phenytoin or placebo for 3 months. Serum levels of phenytoin were monitored and adjusted to between 7...
December 1995: Arteriosclerosis, Thrombosis, and Vascular Biology
L Morgante, S Serra, R Musolino, G Gallitto
Total cholesterol, free cholesterol, HDL cholesterol, LDL cholesterol and triglycerides have been assayed in serum of 42 epileptic patients in chronic therapy (21 in monotherapy and 21 in polytherapy) in comparison with 21 normal controls. Free cholesterol showed an highly significant increase in epileptics, in whom triglycerides appeared very reduced. In contrast to previous reports of a large increase of HDL cholesterol in phenitoin treated patients, only a not significant increase was found. The other parameters appeared unchanged...
February 15, 1981: Bollettino Della Società Italiana di Biologia Sperimentale
M Kaste, A Muuronen, E A Nikkilä, P J Neuvonen
Serum high density lipoprotein (HDL) cholesterol and other lipoproteins were measured in 27 TIA-patients with a mean age of 49 +/- 10 years before and during phenytoin therapy. The pretreatment concentrations of HDL-cholesterol (mmol/l, mean +/- SD) were lower (p less than 0.001) in male (1.03 +/- 0.25) and in female patients (1.15 +/- 0.44) than in healthy male (1.28 +/- 0.34) and female controls (1.52 +/- 0.31) respectively. After one month's phenytoin therapy HDL cholesterol concentrations reached normal levels (men 1...
July 1983: Stroke; a Journal of Cerebral Circulation
R B Wallace, D B Hunninghake, S Reiland, E Barrett-Connor, A Mackenthun, J Hoover, P Wahl
From the 10 North American study populations of the Lipid Research Clinics Program, mean levels of plasma high-density (HDL) cholesterol were contrasted between users of eight categories of prescribed medications and a control group of nonusers of those categories matched for age, sex, study population and ponderosity. Women taking propranolol had a mean HDL cholesterol level 12 mg/dl lower than nonusers (p < 0.05). Men taking phenytoin had a mean HDL cholesterol level more than 18 mg/dl higher than nonusers (p < 0...
November 1980: Circulation
P V Luoma, E A Sotaniemi, R O Pelkonen, H I Pirttiaho
Serum low-density lipoprotein cholesterol and high-density lipoprotein cholesterol concentration and the ratio between them, major risk factors of coronary heart disease, and liver size were investigated in 18 subjects who were on enzyme-inducing anticonvulsants, phenytoin alone or in combination with phenobarbital and/or carbamazepine. The subjects with a high liver cytochrome P-450, indicating hepatic microsomal enzyme induction, who showed an increase in liver size, had an elevated high-density lipoprotein concentration and high-density lipoprotein cholesterol/total cholesterol ratio, and a reduced low/high-density lipoprotein cholesterol ratio...
1985: European Journal of Clinical Pharmacology
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