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Burkitt lymphoma ascites

Alberto L'Abbate, Ilaria Iacobucci, Angelo Lonoce, Antonella Turchiano, Elisa Ficarra, Giulia Paciello, Federica Cattina, Anna Ferrari, Enrica Imbrogno, Claudio Agostinelli, Pierluigi Zinzani, Giovanni Martinelli, Enrico Derenzini, Clelia Tiziana Storlazzi
To date, the lack of chemo-naive cell models limited exploratory studies to define novel therapies for Burkitt lymphoma (BL). To obtain a useful tool for biological and translational studies for this tumor, we established the RALE051 cell line from the malignant ascitic fluid cells of a patient at initial diagnosis, not previously exposed to any treatment. The cell line was characterized by karyotyping, fluorescence in situ hybridization (FISH), single nucleotide polymorphism (SNP) array, immunohistochemistry, and RNA-Seq, revealing the persistence of biological and molecular features observed in the primary ascitic fluid, such as the cell morphology and immunophenotype, the occurrence of a t(8;22) translocation deregulating MYC, knock-out ID3 mutations in a compound homozygous state, and a mutated TP53...
September 11, 2017: Leukemia & Lymphoma
Zeba Choudhary, Prajwala Gupta, Madhumitha Udaya Kumar
No abstract text is available yet for this article.
January 2017: Journal of Clinical and Diagnostic Research: JCDR
Eun Kyung Park, Se Ryeon Lee, Young Chul Kim, Sun Young Oh, Jae Gol Choe
Peritoneal lymphomatosis is uncommon, but when encountered is associated with aggressive histological subtypes of high-grade lymphoma, such as small-cell, large-cell, mixed large and small cell, non-cleaved, lymphoblastic Burkitt-like, and diffuse large B cell lymphomas. The CT findings of peritoneal lymphomatosis are linear or nodular peritoneal thickening, retroperitoneal lymphadenopathy, omental and mesenteric involvement with streak-like infiltrations or a bulky mass, bowel wall thickening, hepatosplenomegaly, and ascites...
June 2010: Nuclear Medicine and Molecular Imaging
Daniel P Widney, Tove Olafsen, Anna M Wu, Christina M R Kitchen, Jonathan W Said, Jeffrey B Smith, Guadalupe Peña, Larry I Magpantay, Manuel L Penichet, Otoniel Martinez-Maza
Currently, few rodent models of AIDS-associated non-Hodgkin's lymphoma (AIDS-NHL) exist. In these studies, a novel mouse/human xenograft model of AIDS-associated Burkitt lymphoma (AIDS-BL) was created by injecting cells of the human AIDS-BL cell line, 2F7, intraperitoneally into NOD-SCID mice. Mice developed tumors in the peritoneal cavity, with metastases to the spleen, thymus, and mesenteric lymph nodes. Expression of the chemokine receptor, CXCR5, was greatly elevated in vivo on BL tumor cells in this model, as shown by flow cytometry...
2013: PloS One
Noriko Miyazaki, Yoichi Kobayashi, Yoshiko Nishigaya, Mai Momomura, Hironori Matsumoto, Mitsutoshi Iwashita
We report an extremely rare case of primary ovarian Burkitt lymphoma. A 15-year-old girl was referred to our department because of persistent constipation and abdominal distension. Abdominal computed tomography and magnetic resonance imaging revealed a 10-cm-diameter solid tumor located on the right side of the uterus. Serum lactate dehydrogenase and carbohydrate antigen-125 levels were elevated at 3250 IU/L and 235.7 U/mL, respectively. Initially, ovarian dysgerminoma was suspected, but poor performance and progressive disease were suggestive of malignant lymphoma...
August 2013: Journal of Obstetrics and Gynaecology Research
Lucia Manganaro, Silvia Bernardo, Maria Eleonora Sergi, Paolo Sollazzo, Valeria Vinci, Alessandra De Grazia, Anna Clerico, Maria Giovanna Mollace, Matteo Saldari
Burkitt's lymphoma is a rare non-Hodgkin's lymphoma which can occasionally involve the ovary and may cause confusion for the clinician since its presentation might mimic other much more frequent tumors. We present a case of a 23-year-old woman with sporadic Burkitt's lymphoma presented as advanced ovarian cancer with bilateral ovarian masses, peritoneal carcinomatosis, ascites, and marked elevation of CA-125. Liver involvement and atypical bone lesions, such as the cranial vault and the iliac wing, were also detected without evidence of lymphadenopathy...
2013: Case Reports in Radiology
Adi Shacham-Abulafia, Ran Nagar, Ram Eitan, Hanoch Levavi, Gad Sabah, Liat Vidal, Ofer Shpilberg, Pia Raanani
Primary Burkitt's lymphoma of the ovary is extremely rare. We report the case of a 39-year-old woman who presented with a 1-month history complaints of night sweats, abdominal pain and dyspnea. Physical examination demonstrated pleural effusions, ascites and an abdominal mass. Imaging showed enlargement of both ovaries extending to the surrounding tissue. Frozen sections on explorative laparotomy suggested granulosa cell tumor of the ovary, and thus extensive debulking was carried out. The final pathological report was compatible with Burkitt's lymphoma...
2013: Acta Haematologica
A C Etonyeaku, O O Akinsanya, O Ariyibi, A J Aiyeyemi
We present a case of bilateral ovarian Burkitt's lymphoma is an 18-year old. Diagnosis was made at histology of specimens obtained after an exploratory (diagnostic) laparotomy. Disease was advanced at presentation and complicated with both chylothorax and chylous ascites. Response to chemotherapy though dramatic was short lived. This underscores the need for high index of suspicion amongst clinicians. The availability of affordable less traumatic diagnostic procedures like laparoscopy and computerized tomography scans with facilities for guided biopsies in resource-poor settings can fast track diagnosis and hence treatment...
2012: Case Reports in Obstetrics and Gynecology
Alesia Kaplan, Arbaz Samad, Michelle M Dolan, Adina M Cioc, Carol J Holman, Stephen C Schmechel, Stefan E Pambuccian
Lymphomas showing both MYC/8q24 rearrangement and IGH@BCL2/t(14;18)(q32;q21), also referred to as "double-hit" or "dual-hit" lymphomas (DHL) are rare B-cell malignancies with a germinal center B-cell immunophenotype and heterogeneous cytologic and histologic features. Such lymphomas may arise de novo or through transformation of follicular lymphomas and are classified either as "B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma (BL)" (most commonly), DLBCL, or, rarely, as B-lymphoblastic lymphoma...
November 2013: Diagnostic Cytopathology
Xiaoyan Wang, Zhifeng Chen, Ganghua Tang, Xiangsong Zhang
A 7-year-old boy presented with increasing abdominal girth and abdominal pain. Abdominal ultrasound revealed a pleural effusion and ascites. Computed tomography (CT) demonstrated a mass involving the peritoneum, mesentery, and omentum with marked ascites, mesenteric nodules, and renal involvement. Positron emission tomography (PET)/CT scan identified additional tumor within the pleura. PET/CT imaging was helpful in identifying the appropriate pleural mass biopsy site in this patient with Burkitt lymphoma.
July 2011: Clinical Nuclear Medicine
Georgios Koukourakis, Vassilios Kouloulias
Non-Hodgkin's lymphoma as a primary testicular neoplasm accounts approximately 9% of all testicular malignant tumours and about 1-2% of all non-Hodgkin's lymphoma. This neoplasm is the most common malignant tumour of the testis in the elderly. The most common histotype in primary forms is the diffuse large B-cell lymphoma, whereas more aggressive histologies such as Burkitt's lymphoma are principal founded in cases of secondary involvement of the testis. Regarding clinical presentation, the most common sign is a unilateral painless scrotal swelling, sometimes with sharp scrotal pain or hydrocele...
May 2010: Clinical & Translational Oncology
Xue-ying Su, Xia Xu, Yuan Tang, Gan-di Li
OBJECTIVE: To study the diagnostic accuracy of hematolymphoid malignancy by using effusion fluid cytology specimens and to evaluate the values of immunocytochemistry for this assay. METHODS: The cytospin preparations/smears and cell block sections of effusion cytology specimens from 33 cases of hematolymphoid malignancy were retrospectively reviewed. Immunocytochemical study was performed. In selected cases, in-situ hybridization for Epstein-Barr virus-encoded RNA and immunoglobulin and T-cell receptor gene rearrangement study were carried out as indicated...
August 2009: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
Jenny Hui Chia Chieng, John Garrett, Steven Leslie Ding, Michael Sullivan
INTRODUCTION: Burkitt lymphoma and B cell lymphomas in childhood may arise in many atypical locations, which on rare occasions can include gastric mucosa. A case of primary gastric Burkitt lymphoma is described in a child presenting as a protein-losing enteropathy, including the direct monitoring of the disease response by sequential endoscopic biopsy and molecular analysis. CASE PRESENTATION: We report a 9-year-old boy who presented with gross oedema, ascites and respiratory distress caused by a protein-losing enteropathy...
June 9, 2009: Journal of Medical Case Reports
Manabu Kawakami, Hiroki Omori, Tamotsu Yamagami, Toshihiro Soma
Methotrexate (MTX) has been documented to accumulate in "third spaces'' such as pleural effusions or ascitic fluids, resulting in delayed clearance and severe toxicity. We present a case of Burkitt lymphoma possessing large liver cysts, up to the size of 7 x 7 cm, wherein clearance of high-dose MTX was severely delayed, despite normal renal and liver functions. The serum MTX concentration was higher than 0.1 microM on day 12 and remained at toxic levels, higher than 0.01 microM, even on day 25, resulting in severe neutropenia, anorexia, and diarrhea...
August 2009: Cancer Chemotherapy and Pharmacology
Filipe Glória Silva, Mafalda Paiva, Ana Tavares, Ana Lacerda, Gabriela Pereira, António Marques, Deolinda Barata, José Cabral
Pancreatitis in children and adolescents is uncommon and its causes are more varied in this age group than in adults. A tumoral aetiology is particularly rare. We present the case of a 13-year-old boy who was admitted to our Intensive Care Unit with the diagnosis of acute pancreatitis, bilateral pleural effusion and ascites. Serial sonographic and computed tomography evaluations were suggestive of an infiltrative process of the gastric wall. Endoscopy showed an infiltrative tumor of the gastric mucosa and duodenum with a giant ulcer...
September 2008: Acta Médica Portuguesa
Devrim Karaosmanoglu, Musturay Karcaaltincaba, Berna Oguz, Deniz Akata, Mustafa Ozmen, Okan Akhan
PURPOSE: We aimed to describe computed tomography (CT) findings in patients with peritoneal, omental and mesenteric lymphoma involvement. MATERIALS AND METHODS: We searched our archive retrospectively to find out patients with peritoneal, omental and mesenteric lymphoma involvement. We found 16 patients with non-Hodgkin lymphoma meeting these criteria. CT studies of these patients were reevaluated for the presence of peritoneal involvement, ascites, omental mass, organomegaly, retroperitoneal lymphadenopathy, bowel wall thickening and other associated findings...
August 2009: European Journal of Radiology
Leszek Gottwald, Jerzy Korczyński, Ewa Góra, Grazyna Pasz-Walczak, Dorota Jesionek-Kupnicka, Andrzej Bieńkiewicz
UNLABELLED: Primary Burkitt lymphoma is a lymphoblastic B-cell malignant tumor with very aggressive course. Its abdominal form involving internal genital organs is very rare. CASE: We report the case of 27-year-old woman treated for abdominal Burkitt lymphoma. The patient presented bilateral ovarian tumors with ascites, pain and elevated CA 125 over 900 IU/ml. During laparotomy an advanced neoplasmatic disease involving internal genital organs has been diagnosed...
February 2008: Ginekologia Polska
Demet Kiresi, Leman Gunbey Karabekmez, Yavuz Koksal, Dilek Emlik
Burkitt lymphoma (BL) is a high-grade, B-cell-originated pediatric malignancy that is a type of non-Hodgkin lymphoma involving different organs. Mediastinal mass, ascites, peritoneal thickening, and infiltration of the small intestine, kidney, and liver were found in our patient. In this case, we describe the radiologic appearances and possible infiltration patterns of multi-organ BL. Also, we discuss infiltration of the periportal area, such as hypodense lesions in the liver, which is rarely seen in BL.
February 2008: Clinical Lymphoma & Myeloma
Umberto Vitolo, Andrés J M Ferreri, Emanuele Zucca
Primary non-Hodgkin's lymphoma of the testis (PTL) accounts for about 9% of testicular neoplasms and 1-2% of all non-Hodgkin's lymphomas. It is the most common testicular malignancy in elder men. Anecdotal reports associated PTL development with trauma, chronic orchitis, cryptorchidism, or filariasis exist, but no case-control studies have confirmed their etiologic significance. Diffuse large B-cell lymphoma (DLBCL) is the most common histotype in primary forms; aggressive histologies, especially Burkitt's lymphoma, are prevalent in cases of secondary involvement of testis...
February 2008: Critical Reviews in Oncology/hematology
Jill K Northup, Swarupa A Gadre, Yimin Ge, Lillian H Lockhart, Gopalrao V N Velagaleti
Cytogenetic evaluation of bone marrow and neoplastic tissues plays a critical role in determining patient management and prognosis. Here, we highlight two cases in which the cytogenetic studies challenge the common practice of using hematologic and morphologic changes as key factors in malignant disease management. The first case is that of a lymph node sample from a 40-yr-old non-Hodgkin's lymphoma (NHL) patient sent for determination of disease progress. Hematologic studies showed no evidence of transformation to high-grade NHL (>15% blasts with rare mitotic figures)...
February 2007: European Journal of Haematology
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