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https://www.readbyqxmd.com/read/29457455/ultrathin-%C3%AE%C2%BA-carrageenan-chitosan-hydrogel-films-with-high-toughness-and-anti-adhesion-property
#1
Hai Chao Yu, He Zhang, Ke-Feng Ren, Zhimin Ying, Fengbo Zhu, Jin Qian, Jian Ji, Zi Liang Wu, Qiang Zheng
Designing tough biopolymer-based hydrogels as structural biomaterials has both scientific and practical significances. We report a facile approach to prepare polysaccharide-based hydrogel films with remarkable mechanical performances and anti-adhesion property. The hydrogel films with thickness of 40-60 μm were prepared by mixing aqueous solutions of κ-carrageenan (κ-CG) and protonated chitosan (CS), evaporating the solvent, and then swelling the casted film in water to achieve the equilibrium state. The obtained κ-CG/CS gel films with water content of 48-88 wt% possessed excellent mechanical properties superior to most existing biopolymer-based hydrogels, with breaking stress of 2-6...
February 19, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29457336/high-school-biology-students-use-of-visual-molecular-dynamics-as-an-authentic-tool-for-learning-about-modeling-as-a-professional-scientific-practice
#2
Stephen R Burgin, Jennifer Oramous, Michael Kaminski, Linda Stocker, Mahmoud Moradi
Modeling is a practice of science that is underemphasized in biology classrooms in comparison to its central focus in the physical sciences. Visualizations of the submicroscopic world of molecules are becoming increasingly sophisticated with the evolution of new technologies. With this in mind, we introduced high school biology classrooms to a professional molecular modeling software program used by research biochemists to visualize proteins and other macromolecules. Analysis of surveys completed before and after the use of the program revealed significant student gains in their understandings of the nature of models...
February 19, 2018: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/29456873/the-rockefeller-university-clinical-scholars-kl2-program-2006-2016
#3
Sarah J Schlesinger, Michelle Romanick, Jonathan N Tobin, Donna Brassil, Rhonda G Kost, Rita Devine, Barbara O'Sullivan, Roger D Vaughan, Yupu Liang, Joel Correa da Rosa, Maija Williams, James G Krueger, Barry S Coller
Introduction and Methods: The Rockefeller Clinical Scholars (KL2) Program began in 1976 and transitioned into a 3-year Master's degree program in 2006 when Rockefeller joined the NIH Clinical and Translational Science Award (CTSA) program. The program consists of ~15 trainees supported by the CTSA KL2 award and University funds. It is designed to provide an optimal environment for junior translational investigators to develop team science and leadership skills by designing and performing a human subjects protocol under the supervision of a distinguished senior investigator mentor and a team of content expert educators...
October 2017: Journal of Clinical and Translational Science
https://www.readbyqxmd.com/read/29456624/the-case-for-a-regional-approach-to-publication-impact
#4
EDITORIAL
Stevan Bruijns, Camillo Lamanna
Healthcare-related research is largely regional. Put simply, this is because disease burdens differ between world regions. Even global burdens, such as ischaemic heart disease and cancer, display distinctive characteristics in certain regions that are not seen in others. Regional differences in infrastructure, resources and human capital further compound the differences seen, as they affect the way in which the local scientific community can interact with the local disease burden. As such, it seems fair to assume that healthcare-related research ought to be regionally distributed...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29456587/dietary-diversity-and-associated-factors-among-children-of-orthodox-christian-mothers-caregivers-during-the-fasting-season-in-dejen-district-north-west-ethiopia
#5
Gemechu Kumera, Endalkachew Tsedal, Mulatu Ayana
Background: Proper feeding practices during early childhood is fundamental for optimal child growth and development. However, scientific evidences on the determinants of dietary diversity are scanty. Particularly, the impact of fasting on children`s dietary diversity is not explored in Ethiopia. The aim of this study was to assess dietary diversity and associated factors among children aged 6-23 months, whose mothers/care-givers were Orthodox Christians during the fasting season (Lent), in Dejen District, North West Ethiopia, 2016...
2018: Nutrition & Metabolism
https://www.readbyqxmd.com/read/29455762/bvs-rdn-iabp-the-afghanistan-of-interventional-cardiology-trials
#6
EDITORIAL
Sundeep Mishra
In the field of medicine and cardiology newer therapy and devices have been launched with a huge promise and a lot of hype. Unfortunately, over the course of time, a good many of them like biovascular scaffold, renal denervation and intra-aortic balloon pump have failed to live up to their initial promise so much so that some of them have been withdrawn. The reason for this downfall may be multifold from incomplete understanding of the patho-physiology of disease, incomplete understanding of mechanism of action of the therapy, in-appropriate application in clinical practice, in-efficient therapy development related to flawed trial design, regulatory impediments placed on the trials or deficits in application of scientific techniques...
January 2018: Indian Heart Journal
https://www.readbyqxmd.com/read/29454209/reconciling-discrepancies-in-the-source-characterization-of-vocs-between-emission-inventories-and-receptor-modeling
#7
Jiamin Ou, Junyu Zheng, Zibing Yuan, Dabo Guan, Zhijiong Huang, Fei Yu, Min Shao, Peter K K Louie
Emission inventory (EI) and receptor model (RM) are two of the three source apportionment (SA) methods recommended by Ministry of Environment of China and used widely to provide independent views on emission source identifications. How to interpret the mixed results they provide, however, were less studied. In this study, a cross-validation study was conducted in one of China's fast-developing and highly populated city cluster- the Pearl River Delta (PRD) region. By utilizing a highly resolved speciated regional EI and a region-wide gridded volatile organic compounds (VOCs) speciation measurement campaign, we elucidated underlying factors for discrepancies between EI and RM and proposed ways for their interpretations with the aim to achieve a scientifically plausible source identification...
February 14, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29452426/open-access-data-capitalism-and-academic-publishing
#8
Michael Hagner
Open Access (OA) is widely considered a breakthrough in the history of academic publishing, rendering the knowledge produced by the worldwide scientific community accessible to all. In numerous countries, national governments, funding institutions and research organisations have undertaken enormous efforts to establish OA as the new publishing standard. The benefits and new perspectives, however, cause various challenges. This essay addresses several issues, including that OA is deeply embedded in the logic and practices of data capitalism...
February 16, 2018: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29451419/physical-exercise-nutrition-and-hormones-three-pillars-to-fight-sarcopenia
#9
Paolo Sgrò, Massimiliano Sansone, Andrea Sansone, Stefania Sabatini, Paolo Borrione, Francesco Romanelli, Luigi Di Luigi
BACKGROUND: Sarcopenia is a pathophysiological condition diffused in elderly people; it represents a social issue due to the longer life expectancy and the growing aging population. It affects negatively quality of life and it represents a risk factor for other pathologies, such as diabetes, cardiovascular disease, and obesity. No silver bullet exists to hinder sarcopenia, but it may be counteracted by physical exercise, nutrition, and a proper endocrine milieu. Indeed, we aim to analyze the scientific literature to give to clinician effective advices to counteract sarcopenia...
February 16, 2018: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/29450596/-strategies-for-a-regenerative-therapy-of-hearing-loss-german-version
#10
REVIEW
M Diensthuber, T Stöver
Despite impressive technical progress in the field of conventional hearing aids and implantable hearing systems, the hopes for the treatment of inner ear diseases such as hearing loss and tinnitus have become increasingly directed toward regenerative therapeutic approaches. This review discusses the currently most promising strategies for hair cell regeneration in the inner ear to treat hearing loss, including stem cell-based, gene transfer-based, and pharmacological interventions. Furthermore, previous milestones and ground-breaking work in this scientific field are identified...
February 15, 2018: HNO
https://www.readbyqxmd.com/read/29448076/single-multi-echo-gre-acquisition-with-short-and-long-echo-spacing-for-simultaneous-quantitative-mapping-of-fat-fraction-b0-inhomogeneity-and-susceptibility
#11
Junmin Liu, Spencer Christiansen, Maria Drangova
Multi-echo gradient echo (mGRE) sequences have been widely adapted in clinical and scientific practice for different purposes to their capability of performing Dixon MRI, generating multi-contrast images and extracting multi-parametric maps. This work aims to extend mGRE-based techniques for imaging whole head, where further technical developments are required due to the co-existence of fat and large B0 inhomogeneity in regions such as the skull base and neck. Specifically, bipolar mGRE data were acquired with a single sequence that contains both a short echo-spacing (ΔTE) echo train to capture water-fat and B0 phase shifts (for proton density fat-fraction (FF) and B0 mapping) and a longer ΔTE echo train (and long echo times) to capture subtle susceptibility variations and R2* information...
February 12, 2018: NeuroImage
https://www.readbyqxmd.com/read/29447356/barriers-to-the-availability-and-accessibility-of-controlled-medicines-for-chronic-pain-in-africa
#12
Elmang Nchako, Scottie Bussell, Carlos Nesbeth, Chisom Odoh
Africans endure a high burden of pain and suffering from HIV/AIDS and cancer, yet receive a meager amount of the world's pain medication. This tragedy occurs needlessly, given that inexpensive, effective and easily administered interventions are available. WHO has a 'three-step analgesic ladder' framework for managing cancer pain. This widely adopted clinical practice guideline is an integral part of palliative care programs and has also been applied to non-cancer pain. However, untreated pain is a major public health problem due to the discordance between scientific evidence and public policy...
February 13, 2018: International Health
https://www.readbyqxmd.com/read/29446865/european-guidance-on-paediatric-use-of-probiotics-states-that-benefits-are-limited-to-several-conditions-and-urges-caution-with-specific-vulnerable-groups
#13
REVIEW
Iva Hojsak, Valentina Fabiano, Tudor Lucian Pop, Olivier Goulet, Gian Vincenzo Zuccotti, Fugen Cullu Çokuğraş, Massimo Pettoello-Mantovani, Sanja Kolaček
AIM: The use of probiotics has been covered by many guidelines, position papers and evidence-based recommendations, but few have referred to specific patient groups or clinical indications. This European study summarises recommendations and scientifically credited guidelines on the use of probiotics for children and provides practice points. METHODS: An expert panel was convened by the European Paediatric Association in June 2017 to define the relevant clinical questions for using probiotics in paediatric healthcare and review and summarise the guidelines, recommendations, position papers and high-quality evidence...
February 15, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29446300/mineralogical-evidence-of-galvanic-corrosion-in-drinking-water-lead-pipe-joints
#14
Michael K DeSantis, Simoni Triantafyllidou, Michael Schock, Darren A Lytle
Galvanic corrosion as a mechanism of toxic lead release into drinking water has been under scientific debate in the U.S. for over 30 years. Visual and mineralogical analysis of 28 lead pipe joints, excavated after 60+ years from 8 U.S. water utilities, provided the first direct view of three distinct galvanic corrosion patterns in practice: (1) no evidence of galvanic corrosion; (2) galvanic corrosion with lead cathode; (3) galvanic corrosion with lead anode. Pattern 3 is consistent with empirical galvanic series (lead→brass→copper in order of increasing nobility) and poses the greatest risk of Pb exposure...
February 15, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29445605/the-state-of-uniportal-video-assisted-thoracoscopic-surgery-in-north-america-a-survey-of-thoracic-surgeons
#15
Ching Yeung, Sebastien Gilbert
Background: In recent years, there has been an exponential growth in the research and development of uniportal video-assisted thoracoscopic surgery (VATS). In the context of the 2017 Annual Asian Single-Port VATS Symposium held in Shanghai, China, we sought to describe current the state of uniportal VATS in North America and explore factors that could influence future adoption. Methods: In March 2017, a five-question survey was distributed to North American Thoracic Surgeons in order to obtain their opinion regarding the uniportal VATS approach to pulmonary resection...
2018: Journal of Visualized Surgery
https://www.readbyqxmd.com/read/29444996/a-model-of-analysis-in-analytical-methodology-for-biopharmaceutical-quality-control
#16
Cleyton Andrade, Miguel de la O Herrera, Elezer Lemes
One key quality control parameter for biopharmaceutical products is the analysis of residual cellular DNA (rcDNA). To determine small amounts of DNA (around 100pg) that may be in a biologically-derived drug substance, an analytical method should be sensitive, robust, reliable and accurate. In principle, three techniques have the ability to measure rcDNA: radioactive dot-blot a type of Hybridization; Threshold and quantitative Polymerase Chain Reaction (qPCR). Quality Risk Management (QRM) is a systematic process for evaluating, controlling and reporting of risks which may affects method capabilities and supports a scientific and practical approach to decision making...
February 14, 2018: PDA Journal of Pharmaceutical Science and Technology
https://www.readbyqxmd.com/read/29441772/-current-status-of-forensic-identification-for-blunt-injuries-of-internal-carotid-arterial-system
#17
REVIEW
X M Wu, G Zhang, Q Wang, Z X Ni, M Liu, L B Yun, X F Yi
Internal carotid arterial system is the main source of blood supply in brain. In forensic identification practice, blunt injures of internal carotid arterial system usually cause complications such as thrombus, aneurysm and arteriovenous fistula, etc. The deaths following delayed cerebral infarction or intracranial haemorrhage are not rare. At present, literature of deaths caused by blunt injuries of internal carotid arterial system mainly consist of case reports in China. This paper reviews related literature and case reports at home and abroad, and summarizes forensic medical features and identification method of the deaths caused by such injuries...
December 2017: Fa Yi Xue za Zhi
https://www.readbyqxmd.com/read/29441123/circulation-first-the-time-has-come-to-question-the-sequencing-of-care-in-the-abcs-of-trauma-an-american-association-for-the-surgery-of-trauma-multicenter-trial
#18
Paula Ferrada, Rachael A Callcut, David J Skarupa, Therese M Duane, Alberto Garcia, Kenji Inaba, Desmond Khor, Vincent Anto, Jason Sperry, David Turay, Rachel M Nygaard, Martin A Schreiber, Toby Enniss, Michelle McNutt, Herb Phelan, Kira Smith, Forrest O Moore, Irene Tabas, Joseph Dubose
Background: The traditional sequence of trauma care: Airway, Breathing, Circulation (ABC) has been practiced for many years. It became the standard of care despite the lack of scientific evidence. We hypothesized that patients in hypovolemic shock would have comparable outcomes with initiation of bleeding treatment (transfusion) prior to intubation (CAB), compared to those patients treated with the traditional ABC sequence. Methods: This study was sponsored by the American Association for the Surgery of Trauma multicenter trials committee...
2018: World Journal of Emergency Surgery: WJES
https://www.readbyqxmd.com/read/29440963/heritage-of-stanis%C3%A5-aw-ostrowski-the-only-one-medical-doctor-who-became-state-polish-president-patriae-semper-fidelis
#19
Martyna Woltanowska, Piotr Woltanowski, Andrzej Wincewicz, Magdalena Woltanowska
Aim: Our purpose was to write a biography of Stanisław Ostrowski that would address in the first place the medical aspect of his professional life, with a comprehensive approach of others fields of his activity. Methods: We essentially grounded the paper on primary resources that were papers authored by Ostrowski including his scientific publications, memories, speeches as well as contemporaneous official documents that referred to Ostrowski. Second resources were also used to double check some data from primary resources and to place the biography of Stanisław Ostrowski in a proper background with special care to social, professional and political context...
2018: Clujul Medical (1957)
https://www.readbyqxmd.com/read/29440850/a-meta-analysis-on-evidence-of-platelet-rich-plasma-for-androgenetic-alopecia
#20
Salvatore Giordano, Marco Romeo, Pietro di Summa, Andre' Salval, Petteri Lankinen
Background: Platelet-rich plasma (PRP) treatment has gained popularity among different surgical specialities for improving various conditions. Androgenetic alopecia (AGA) is a common disorder, with possible psychosocial implications. Plastic surgeons have increased the practice of PRP injections for hair restoration. A meta-analysis on this topic was performed comparing local injection of PRP versus control to investigate the efficacy of local PRP injections in AGA. Methods: We performed a systematic literature search...
January 2018: International Journal of Trichology
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