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hypertonic saline nebulization

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https://www.readbyqxmd.com/read/28859915/viral-bronchiolitis-in-young-infants-new-perspectives-for-management-and-treatment
#1
REVIEW
Mauricio T Caballero, Fernando P Polack, Renato T Stein
OBJECTIVE: The aim of this review was to address advances in management and treatment of acute viral bronchiolitis in infants. SOURCES: A systematic review search was made including all articles published in English between 2010 and 2017, and available in the electronic databases PubMed and Cochrane Central Register of Controlled Trials (CENTRAL) and specialized register of the Acute Respiratory Infections Group (Cochrane review group). The following MESH terms in English were included, using different Boolean operators for the search strategy: "bronchiolitis, viral," "diagnosis," "epidemiology," "etiology," "therapy," "virology," "prevention and control," "respiratory syncytial virus, human...
August 30, 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/28814254/bronchiolitis-care-in-the-hospital
#2
Jennifer Orr Vincent, Huay-Ying Lo, Susan Wu
BACKGROUND: Viral bronchiolitis is a common cause of hospitalization in young children, but despite a variety of therapeutic options, the mainstay of treatment remains supportive care. OBJECTIVE: To examine the most recent evidence for supportive care measures and pharmacologic options in the treatment of bronchiolitis in the hospital setting Methods: MEDLINE search with expert medical librarian for publications on management and therapies for bronchiolitis Results: Evidence does not support the use of bronchodilators, racemic epinephrine, deep suctioning, systemic corticosteroids, or antibiotics in the absence of a concomitant bacterial infection, as these treatments do not change the course of illness or shorten length of stay (LOS)...
August 16, 2017: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/28761004/multicenter-observational-study-of-the-use-of-nebulized-hypertonic-saline-to-treat-children-hospitalized-for-bronchiolitis-from-2008-to-2014
#3
Joshua Davis, Amy D Thompson, Jonathan M Mansbach, Pedro A Piedra, Kohei Kasagawa, Ashley F Sullivan, Janice A Espinola, Carlos A Camargo
OBJECTIVES: Among children hospitalized for bronchiolitis, we examined temporal trends in the use of hypertonic saline (HTS) and the characteristics associated with receiving this treatment. METHODS: We conducted a secondary analysis of data from 2 large, multicenter prospective cohort studies that included young children hospitalized with bronchiolitis during 5 winter seasons (2008-2014). Our outcome was receipt of HTS any time during the preadmission visit or hospitalization...
July 31, 2017: Hospital Pediatrics
https://www.readbyqxmd.com/read/28738709/nebulized-hypertonic-saline-to-prevent-ventilator-associated-pneumonia-in-premature-infants-a-randomized-trial
#4
Zahra Ezzeldin, Yasmeen Mansi, Mervat Gaber, Rania Zakaria, Rehab Fawzy, Mohamed A Mohamed
BACKGROUND/OBJECTIVES: Ventilator associated pneumonia (VAP) is a leading cause of death. Nebulized hypertonic saline solution (HSS) has been used to improve pulmonary clearance and reduce infection in intubated patients. This study examines whether nebulized HSS may reduce VAP in intubated premature infants. METHODS: We analyzed results of 100 intubated premature infants who completed the study. Infants were divided into: (a) the "Control" group, where VAP prevention protocol was implemented and (b) the "Intervention" group, where nebulized HSS twice daily was added to the package of care...
August 8, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28649564/primary-ciliary-dyskinesia-an-update-on-clinical-aspects-genetics-diagnosis-and-future-treatment-strategies
#5
REVIEW
Virginia Mirra, Claudius Werner, Francesca Santamaria
Primary ciliary dyskinesia (PCD) is an orphan disease (MIM 244400), autosomal recessive inherited, characterized by motile ciliary dysfunction. The estimated prevalence of PCD is 1:10,000 to 1:20,000 live-born children, but true prevalence could be even higher. PCD is characterized by chronic upper and lower respiratory tract disease, infertility/ectopic pregnancy, and situs anomalies, that occur in ≈50% of PCD patients (Kartagener syndrome), and these may be associated with congenital heart abnormalities...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28647745/early-halt-of-a-randomized-controlled-study-with-3-hypertonic-saline-in-acute-bronchiolitis
#6
Ania Carsin, Emilie Sauvaget, Violaine Bresson, Karine Retornaz, Maria Cabrera, Elisabeth Jouve, Romain Truillet, Emmanuelle Bosdure, Jean-Christophe Dubus
BACKGROUND: Albeit not recommended because of contradictory results, nebulized 3% hypertonic saline is widely used for treating acute viral bronchiolitis. Whether clinical differences may be attributed to the type of nebulizer used has never been studied. OBJECTIVES: By modifying the amount of salt deposited into the airways, the nebulizer characteristics might influence clinical response. METHODS: A prospective, randomized, controlled trial included infants hospitalized in a French university hospital for a first episode of bronchiolitis...
June 24, 2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/28586918/effect-of-nebulized-hypertonic-saline-treatment-in-emergency-departments-on-the-hospitalization-rate-for-acute-bronchiolitis-a-randomized-clinical-trial
#7
RANDOMIZED CONTROLLED TRIAL
François Angoulvant, Xavier Bellêttre, Karen Milcent, Jean-Paul Teglas, Isabelle Claudet, Christèle Gras Le Guen, Loïc de Pontual, Philippe Minodier, François Dubos, Jacques Brouard, Valérie Soussan-Banini, Vanessa Degas-Bussiere, Amélie Gatin, Cyril Schweitzer, Ralph Epaud, Amélie Ryckewaert, Pierrick Cros, Yves Marot, Philippe Flahaut, Pascal Saunier, Philippe Babe, Géraldine Patteau, Mathilde Delebarre, Luigi Titomanlio, Bénédicte Vrignaud, Thanh-Van Trieu, Abdelilah Tahir, Delphine Regnard, Pascale Micheau, Oussama Charara, Simon Henry, Dominique Ploin, Henri Panjo, Astrid Vabret, Jean Bouyer, Vincent Gajdos
Importance: Acute bronchiolitis is the leading cause of hospitalization among infants. Previous studies, underpowered to examine hospital admission, have found a limited benefit of nebulized hypertonic saline (HS) treatment in the pediatric emergency department (ED). Objective: To examine whether HS nebulization treatment would decrease the hospital admission rate among infants with a first episode of acute bronchiolitis. Design, Setting, and Participants: The Efficacy of 3% Hypertonic Saline in Acute Viral Bronchiolitis (GUERANDE) study was a multicenter, double-blind randomized clinical trial on 2 parallel groups conducted during 2 bronchiolitis seasons (October through March) from October 15, 2012, through April 15, 2014, at 24 French pediatric EDs...
August 7, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28286262/iv-magnesium-sulfate-for-bronchiolitis-a-randomized-trial
#8
RANDOMIZED CONTROLLED TRIAL
Khalid Alansari, Rafah Sayyed, Bruce L Davidson, Shahaza Al Jawala, Mohamed Ghadier
BACKGROUND: The goal of this study was to determine if IV magnesium, useful for severe pediatric asthma, reduces time to medical readiness for discharge in patients with bronchiolitis when added to supportive care. METHODS: We compared a single dose of 100 mg/kg of IV magnesium sulfate vs placebo for acute bronchiolitis. Patients received bronchodilator therapy, nebulized hypertonic saline, and 5 days of dexamethasone if there was eczema and/or a family history of asthma...
July 2017: Chest
https://www.readbyqxmd.com/read/28157412/a-trans-nasal-aerosol-delivery-device-for-efficient-pulmonary-deposition
#9
Kirby L Zeman, Juan Rojas Balcazar, Fred Fuller, Karl H Donn, Richard C Boucher, William D Bennett, Scott H Donaldson
BACKGROUND: Efficient delivery of aerosols to the lungs via the nasal route has been difficult to achieve, but it may offer benefits over the traditional oral route for a range of patient populations. Because slow, continuous delivery of short-acting agents could improve safety, tolerability, compliance, and efficacy when compared with the rapid, intermittent aerosol treatments delivered by mouthpiece or mask, a novel trans-nasal pulmonary aerosol delivery (tPAD) device was developed...
August 2017: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/28049113/update-on-pediatric-overuse
#10
REVIEW
Eric R Coon, Paul C Young, Ricardo A Quinonez, Daniel J Morgan, Sanket S Dhruva, Alan R Schroeder
As concerns over health care-related harms and costs continue to mount, efforts to identify and combat medical overuse are needed. Although much of the recent attention has focused on health care for adults, children are also harmed by overuse. Using a structured PubMed search and manual tables of contents review, we identified important articles on pediatric overuse published in 2015. These articles were evaluated according to the quality of the methods, the magnitude of clinical effect, and the number of patients potentially affected and were categorized into overdiagnosis, overtreatment, and overutilization...
February 2017: Pediatrics
https://www.readbyqxmd.com/read/27965333/nebulized-epinephrine-for-young-children-with-bronchiolitis
#11
Teeranai Sakulchit, Ran D Goldman
QUESTION: Every winter I see infants with flulike symptoms and wheezing. I frequently diagnose them with bronchiolitis based on their presenting symptoms. Would it be prudent to send those infants to the nearest emergency department for treatment with nebulized epinephrine? ANSWER: Nebulized epinephrine should not be routinely used in infants with bronchiolitis. It is an option to consider in those with severe symptoms. If it is given and there are no signs of improvement, further doses are discouraged...
December 2016: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/27938371/the-role-of-osmolality-in-saline-fluid-nebulization-after-tracheostomy-time-for-changing
#12
Zunjia Wen, Chao Wu, Feifei Cui, Haiying Zhang, Binbin Mei, Meifen Shen
BACKGROUND: Saline fluid nebulization is highly recommend to combat the complications following tracheostomy, yet the understandings on the role of osmolality in saline solution for nebulization remain unclear. OBJECTIVES: To investigate the biological changes in the early stage after tracheostomy, to verify the efficacy of saline fluid nebulization and explore the potential role of osmolality of saline nebulization after tracheostomy. METHODS: Sprague-Dawley rats undergone tracheostomy were taken for study model, the sputum viscosity was detected by rotational viscometer, the expressions of TNF-α, AQP4 in bronchoalveolar lavage fluid were assessed by western blot analysis, and the histological changes in endothelium were evaluated by HE staining and scanning electron microscopy (SEM)...
December 9, 2016: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/27843856/induced-sputum-versus-bronchial-washings-in-the-diagnosis-of-sputum-negative-pulmonary-tuberculosis
#13
Gopathi Nageswar Rao, Mandava Venu, Namballa Usha Rani, Makala Sravani
INTRODUCTION: Tuberculosis (TB) is one of the most important public health problems worldwide. Detecting patients with active pulmonary TB (PT) is an important component of TB control programs. However, at times in patients even with a compatible clinical picture, sputum smears do not reveal acid-fast bacilli (AFB) and smear-negative PT remains a common problem. This study compares the results of induced sputum (IS) and bronchial washings (BWs) in detecting sputum negative PT. MATERIALS AND METHODS: A prospective study conducted from June 2014 to June 2015, comprising 120 patients fulfilling study criteria...
April 2016: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/27553481/is-nebulized-hypertonic-saline-solution-effective-for-acute-bronchiolitis
#14
EDITORIAL
Jennifer H Chao, Richard Sinert
No abstract text is available yet for this article.
January 2017: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/27492738/impact-of-the-implementation-of-an-evidence-based-guideline-on-diagnostic-testing-management-and-clinical-outcomes-for-infants-with-bronchiolitis
#15
Ricardo Henao-Villada, Monica P Sossa-Briceño, Carlos E Rodríguez-Martínez
BACKGROUND: Although bronchiolitis poses a significant health problem in low- and middle-income countries (LMICs), to the best of our knowledge, to date it has not been determined whether evidence-based bronchiolitis clinical practice guidelines (CPGs) complemented by standardized educational strategies reduce the use of unnecessary diagnostic tests and medications and improve clinically important outcomes in LMICs. METHODS: In an uncontrolled before and after study, we assessed the impact of the implementation of an evidence-based bronchiolitis CPG on physician behavior and the care of infants with bronchiolitis by comparing pre-guideline (March to August 2014) and post-guideline (March to August 2015) use of diagnostic tests and medications through an electronic medical record review in a children's hospital in Bogota, Colombia...
October 2016: Therapeutic Advances in Respiratory Disease
https://www.readbyqxmd.com/read/27403389/comparing-the-efficacy-of-7-3-and-0-9-saline-in-moderate-to-severe-bronchiolitis-in-infants
#16
Seçil Köse, Ahmet Şehriyaroğlu, Feyza Esen, Ahmet Özdemir, Zehra Kardaş, Umut Altuğ, Esef Karakuş, Alper Özcan, Ali Fatih Kısaarslan, Ferhan Elmalı, Yasemin Altuner Torun, Mehmet Köse
BACKGROUND: There is no standard treatment option in acute bronchiolitis. 3-7% hypertonic saline (HS) seems to be the effective treatment choice for reducing the hospitalization day. AIMS: To compare the effect of nebulized 7% HS/salbutamol and 3% HS/salbutamol to 0.9% saline/salbutamol. The primary outcome measure was the effect of study drugs on the length of hospital stay (LOS). Secondary outcome measures were safety and efficacy in reducing the clinical severity score (CSS) at the 24 hours of the study...
March 2016: Balkan Medical Journal
https://www.readbyqxmd.com/read/27393775/chronic-rhinosinusitis-in-patients-with-cystic-fibrosis
#17
Daniel L Hamilos
Chronic rhinosinusitis (CRS) is highly prevalent in patients with cystic fibrosis (CF) and accounts for significant morbidity and contribution to CF lung disease. Mutations of the cystic fibrosis transmembrane regulator gene occur with increased prevalence in patients with CRS without CF, suggesting some contribution to CRS pathophysiology. Nasal polyps (NPs) occur with increased prevalence in patients with CF of all ages and have a more neutrophilic appearance with fewer eosinophils and increased submucosal glandular elements in comparison to NPs from patients without CF...
July 2016: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/27141475/effectiveness-of-3-hypertonic-saline-nebulization-in-acute-bronchiolitis-among-indian-children-a-quasi-experimental-study
#18
Harsh V Gupta, Vivek V Gupta, Gurmeet Kaur, Amitoz S Baidwan, Pardeep P George, Jay C Shah, Kushal Shinde, Ruku Malik, Neha Chitkara, Krushnan V Bajaj
OBJECTIVE: To compare the effects of 3% hypertonic saline (HS) and 0.9% normal saline with nebulized 0.9% normal saline with salbutamol in patients of acute viral bronchiolitis. MATERIALS AND METHODS: Participants were divided into three groups, that is, 3% HS group, 0.9% normal saline group and 0.9% saline with salbutamol group. Four doses at interval of 6 h were given daily until discharge. Average CS score and length of hospital stay were compared. One-way analysis of variance paired t-test and Chi-square test were utilized for statistical analysis...
April 2016: Perspectives in Clinical Research
https://www.readbyqxmd.com/read/27134911/a-comparative-study-of-induced-sputum-and-bronchial-washings-in-diagnosing-sputum-smear-negative-pulmonary-tuberculosis
#19
Nageswar Rao Gopathi, Venu Mandava, Usha Rani Namballa, Sravani Makala
INTRODUCTION: Tuberculosis is one of the most important public health problem worldwide. Detecting patients with active pulmonary Koch's disease is an important component of tuberculosis control programs. However, at times in patients even with a compatible clinical picture, sputum smears do not reveal acid-fast bacilli and smear-negative pulmonary tuberculosis remains a common problem. AIM: The present study is aimed to compare the results of induced sputum and bronchial washings smear in patients suspected to have sputum smear negative pulmonary tuberculosis...
March 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27121626/should-we-nebulize-hypertonic-saline-prophylactically-in-our-pediatric-intubated-patients
#20
EDITORIAL
Ruben D Restrepo, Diana M Serrato
No abstract text is available yet for this article.
May 2016: Respiratory Care
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