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hypertonic saline nebulization

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https://www.readbyqxmd.com/read/27843856/induced-sputum-versus-bronchial-washings-in-the-diagnosis-of-sputum-negative-pulmonary-tuberculosis
#1
Gopathi Nageswar Rao, Mandava Venu, Namballa Usha Rani, Makala Sravani
INTRODUCTION: Tuberculosis (TB) is one of the most important public health problems worldwide. Detecting patients with active pulmonary TB (PT) is an important component of TB control programs. However, at times in patients even with a compatible clinical picture, sputum smears do not reveal acid-fast bacilli (AFB) and smear-negative PT remains a common problem. This study compares the results of induced sputum (IS) and bronchial washings (BWs) in detecting sputum negative PT. MATERIALS AND METHODS: A prospective study conducted from June 2014 to June 2015, comprising 120 patients fulfilling study criteria...
April 2016: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/27553481/is-nebulized-hypertonic-saline-solution-effective-for-acute-bronchiolitis
#2
Jennifer H Chao, Richard Sinert
No abstract text is available yet for this article.
August 20, 2016: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/27492738/impact-of-the-implementation-of-an-evidence-based-guideline-on-diagnostic-testing-management-and-clinical-outcomes-for-infants-with-bronchiolitis
#3
Ricardo Henao-Villada, Monica P Sossa-Briceño, Carlos E Rodríguez-Martínez
BACKGROUND: Although bronchiolitis poses a significant health problem in low- and middle-income countries (LMICs), to the best of our knowledge, to date it has not been determined whether evidence-based bronchiolitis clinical practice guidelines (CPGs) complemented by standardized educational strategies reduce the use of unnecessary diagnostic tests and medications and improve clinically important outcomes in LMICs. METHODS: In an uncontrolled before and after study, we assessed the impact of the implementation of an evidence-based bronchiolitis CPG on physician behavior and the care of infants with bronchiolitis by comparing pre-guideline (March to August 2014) and post-guideline (March to August 2015) use of diagnostic tests and medications through an electronic medical record review in a children's hospital in Bogota, Colombia...
October 2016: Therapeutic Advances in Respiratory Disease
https://www.readbyqxmd.com/read/27403389/comparing-the-efficacy-of-7-3-and-0-9-saline-in-moderate-to-severe-bronchiolitis-in-infants
#4
Seçil Köse, Ahmet Şehriyaroğlu, Feyza Esen, Ahmet Özdemir, Zehra Kardaş, Umut Altuğ, Esef Karakuş, Alper Özcan, Ali Fatih Kısaarslan, Ferhan Elmalı, Yasemin Altuner Torun, Mehmet Köse
BACKGROUND: There is no standard treatment option in acute bronchiolitis. 3-7% hypertonic saline (HS) seems to be the effective treatment choice for reducing the hospitalization day. AIMS: To compare the effect of nebulized 7% HS/salbutamol and 3% HS/salbutamol to 0.9% saline/salbutamol. The primary outcome measure was the effect of study drugs on the length of hospital stay (LOS). Secondary outcome measures were safety and efficacy in reducing the clinical severity score (CSS) at the 24 hours of the study...
March 2016: Balkan Medical Journal
https://www.readbyqxmd.com/read/27393775/chronic-rhinosinusitis-in-patients-with-cystic-fibrosis
#5
Daniel L Hamilos
Chronic rhinosinusitis (CRS) is highly prevalent in patients with cystic fibrosis (CF) and accounts for significant morbidity and contribution to CF lung disease. Mutations of the cystic fibrosis transmembrane regulator gene occur with increased prevalence in patients with CRS without CF, suggesting some contribution to CRS pathophysiology. Nasal polyps (NPs) occur with increased prevalence in patients with CF of all ages and have a more neutrophilic appearance with fewer eosinophils and increased submucosal glandular elements in comparison to NPs from patients without CF...
July 2016: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/27141475/effectiveness-of-3-hypertonic-saline-nebulization-in-acute-bronchiolitis-among-indian-children-a-quasi-experimental-study
#6
Harsh V Gupta, Vivek V Gupta, Gurmeet Kaur, Amitoz S Baidwan, Pardeep P George, Jay C Shah, Kushal Shinde, Ruku Malik, Neha Chitkara, Krushnan V Bajaj
OBJECTIVE: To compare the effects of 3% hypertonic saline (HS) and 0.9% normal saline with nebulized 0.9% normal saline with salbutamol in patients of acute viral bronchiolitis. MATERIALS AND METHODS: Participants were divided into three groups, that is, 3% HS group, 0.9% normal saline group and 0.9% saline with salbutamol group. Four doses at interval of 6 h were given daily until discharge. Average CS score and length of hospital stay were compared. One-way analysis of variance paired t-test and Chi-square test were utilized for statistical analysis...
April 2016: Perspectives in Clinical Research
https://www.readbyqxmd.com/read/27134911/a-comparative-study-of-induced-sputum-and-bronchial-washings-in-diagnosing-sputum-smear-negative-pulmonary-tuberculosis
#7
Nageswar Rao Gopathi, Venu Mandava, Usha Rani Namballa, Sravani Makala
INTRODUCTION: Tuberculosis is one of the most important public health problem worldwide. Detecting patients with active pulmonary Koch's disease is an important component of tuberculosis control programs. However, at times in patients even with a compatible clinical picture, sputum smears do not reveal acid-fast bacilli and smear-negative pulmonary tuberculosis remains a common problem. AIM: The present study is aimed to compare the results of induced sputum and bronchial washings smear in patients suspected to have sputum smear negative pulmonary tuberculosis...
March 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27121626/should-we-nebulize-hypertonic-saline-prophylactically-in-our-pediatric-intubated-patients
#8
EDITORIAL
Ruben D Restrepo, Diana M Serrato
No abstract text is available yet for this article.
May 2016: Respiratory Care
https://www.readbyqxmd.com/read/27088767/association-between-hypertonic-saline-and-hospital-length-of-stay-in-acute-viral-bronchiolitis-a-reanalysis-of-2-meta-analyses
#9
Corinne G Brooks, Wade N Harrison, Shawn L Ralston
IMPORTANCE: Two previous meta-analyses of nebulized hypertonic saline (HS) on hospital length of stay (LOS) in acute viral bronchiolitis have suggested benefit. Neither study fully addressed the issue of excessive heterogeneity in the cohort of studies, indicating that it may be inappropriate to combine such dissimilar studies to estimate a common treatment effect. OBJECTIVE: To reanalyze the existing data set for sources of heterogeneity to delineate the population most likely to benefit from HS...
June 1, 2016: JAMA Pediatrics
https://www.readbyqxmd.com/read/27033109/zhang-et-al-nebulized-hypertonic-saline-for-acute-bronchiolitis-a-systematic-review-pediatrics-2015-136-4-687-701-doi-10-1542-peds-2015-1914
#10
(no author information available yet)
No abstract text is available yet for this article.
April 2016: Pediatrics
https://www.readbyqxmd.com/read/26997926/hypertonic-saline-for-the-treatment-of-bronchiolitis-in-infants-and-young-children-a-critical-review-of-the-literature
#11
REVIEW
Jeffrey Baron, Gladys El-Chaar
Bronchiolitis, an infection of the lower respiratory tract, is the leading cause of infant and child hospitalization in the United States. Therapeutic options for management of bronchiolitis are limited. Hypertonic saline inhalation therapy has been studied in numerous clinical trials with mixed results. In 2014, the American Academy of Pediatrics (AAP) published updated guidelines on the diagnosis and management of bronchiolitis, which include new recommendations on the use of hypertonic saline. We reviewed all published clinical trials mentioned in the 2014 AAP guidelines, as well as additional trials published since the guidelines, and critically evaluated each trial to determine efficacy, safety, and expectations of hypertonic saline inhalation therapy...
January 2016: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/26732142/prophylactic-use-of-nebulized-hypertonic-saline-in-mechanically-ventilated-children-a-randomized-blinded-pilot-study
#12
Steven L Shein, John T Gallagher, Kathleen M Deakins, Dayna M Weinert
BACKGROUND: Mucolytic agents, such as nebulized hypertonic saline, may improve airway clearance and shorten the duration of mechanical ventilation, but prospective blinded studies in children undergoing mechanical ventilation are lacking. METHODS: Children <18 y old who had been intubated for <12 h and had an expected duration of mechanical ventilation of >48 additional h were prophylactically given 3 mL of either nebulized hypertonic saline or placebo (0...
May 2016: Respiratory Care
https://www.readbyqxmd.com/read/26678320/infection-and-inflammation-in-induced-sputum-from-preschool-children-with-chronic-airways-diseases
#13
Anja Jochmann, Luca Artusio, Karen Robson, Prasad Nagakumar, Nicola Collins, Louise Fleming, Andrew Bush, Sejal Saglani
BACKGROUND: We hypothesized airway inflammation can be detected non-invasively by induced sputum (IS) or peripheral blood eosinophilia, and IS can detect bacterial and viral infection in preschool children with airway disease, with results comparable to broncho-alveolar lavage (BAL). METHODS: Preschool children with cystic fibrosis, recurrent wheeze, or wet cough underwent IS with nebulized hypertonic saline, chest physiotherapy, and oropharyngeal suction. Samples were analyzed for inflammation by cytology and bacterial culture, viral detection by PCR...
August 2016: Pediatric Pulmonology
https://www.readbyqxmd.com/read/26575101/impact-of-varying-physical-activity-levels-on-airway-sensitivity-and-bronchodilation-in-healthy-humans
#14
Joshua R Smith, Stephanie P Kurti, Ariel M Johnson, Sarah A Kolmer, Craig Harms
The purpose of this study was to determine if the amount of physical activity influences airway sensitivity and bronchodilation in healthy subjects across a range of physical activity levels. Thirty healthy subjects (age, 21.9 ± 2.6 years; 13 men/17 women) with normal pulmonary function reported to the laboratory on 2 separate occasions where they were randomized to breathe either hypertonic saline (HS) (nebulized hypertonic saline (25%) for 20 min) or HS followed by 5 deep inspirations (DIs), which has been reported to bronchodilate the airways...
December 2015: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/26575036/epinephrine-improves-the-efficacy-of-nebulized-hypertonic-saline-in-moderate-bronchiolitis-a-randomised-clinical-trial
#15
RANDOMIZED CONTROLLED TRIAL
J Carlos Flores-González, Miguel A Matamala-Morillo, Patricia Rodríguez-Campoy, Juan J Pérez-Guerrero, Belén Serrano-Moyano, Paloma Comino-Vazquez, Encarnación Palma-Zambrano, Rocio Bulo-Concellón, Vanessa Santos-Sánchez, Alfonso M Lechuga-Sancho
BACKGROUND AND AIMS: There is no evidence that the epinephrine-3% hypertonic saline combination is more effective than 3% hypertonic saline alone for treating infants hospitalized with acute bronchiolitis. We evaluated the efficacy of nebulized epinephrine in 3% hypertonic saline. PATIENTS AND METHODS: We performed a randomized, double-blind, placebo-controlled clinical trial in 208 infants hospitalized with acute moderate bronchiolitis. Infants were randomly assigned to receive nebulized 3% hypertonic saline with either 3 mL of epinephrine or 3 mL of placebo, administered every four hours...
2015: PloS One
https://www.readbyqxmd.com/read/26553190/3-hypertonic-saline-versus-normal-saline-in-inpatient-bronchiolitis-a-randomized-controlled-trial
#16
RANDOMIZED CONTROLLED TRIAL
Alyssa H Silver, Nora Esteban-Cruciani, Gabriella Azzarone, Lindsey C Douglas, Diana S Lee, Sheila Liewehr, Joanne M Nazif, Ilir Agalliu, Susan Villegas, Hai Jung H Rhim, Michael L Rinke, Katherine O'Connor
BACKGROUND AND OBJECTIVES: Bronchiolitis, the most common reason for hospitalization in children younger than 1 year in the United States, has no proven therapies effective beyond supportive care. We aimed to investigate the effect of nebulized 3% hypertonic saline (HS) compared with nebulized normal saline (NS) on length of stay (LOS) in infants hospitalized with bronchiolitis. METHODS: We conducted a prospective, randomized, double-blind, controlled trial in an urban tertiary care children's hospital in 227 infants younger than 12 months old admitted with a diagnosis of bronchiolitis (190 completed the study); 113 infants were randomized to HS (93 completed the study), and 114 to NS (97 completed the study)...
December 2015: Pediatrics
https://www.readbyqxmd.com/read/26416925/nebulized-hypertonic-saline-for-acute-bronchiolitis-a-systematic-review
#17
REVIEW
Linjie Zhang, Raúl A Mendoza-Sassi, Terry P Klassen, Claire Wainwright
BACKGROUND AND OBJECTIVE: The mainstay of treatment for acute bronchiolitis remains supportive care. The objective of this study was to assess the efficacy and safety of nebulized hypertonic saline (HS) in infants with acute bronchiolitis. METHODS: Data sources included PubMed and the Virtual Health Library of the Latin American and Caribbean Center on Health Sciences Information up to May 2015. Studies selected were randomized or quasi-randomized controlled trials comparing nebulized HS with 0...
October 2015: Pediatrics
https://www.readbyqxmd.com/read/26357896/nebulised-hypertonic-saline-3-among-children-with-mild-to-moderately-severe-bronchiolitis-a-double-blind-randomized-controlled-trial
#18
RANDOMIZED CONTROLLED TRIAL
Aayush Khanal, Arun Sharma, Srijana Basnet, Pushpa Raj Sharma, Fakir Chandra Gami
BACKGROUND: To Assess the efficacy of nebulised hypertonic saline (HS) (3%) among children with mild to moderately severe bronchiolitis. METHODS: Infants aged 6 weeks to 24 months, with a first episode of wheezing and Clinical Severity scores (Arch Dis Child 67:289-93, 1992) between 1 and 8, were enrolled over 4 months duration. Those with severe disease, co-morbidities, prior wheezing, recent bronchodilator and steroid use were excluded. Patients were randomized in a double-blind fashion, to receive two doses of nebulized 3% HS (Group 1) or 0...
2015: BMC Pediatrics
https://www.readbyqxmd.com/read/26334188/a-randomized-trial-of-nebulized-3-hypertonic-saline-with-salbutamol-in-the-treatment-of-acute-bronchiolitis-in-hospitalized-infants
#19
Pedro Flores, Ana Luisa Mendes, Ana S Neto
OBJECTIVE: Acute bronchiolitis is a common disorder of infants that often results in hospitalization. Apart from supportive care, no therapy has been shown to influence the course of the disease, except for a possible effect of nebulized hypertonic saline (HS). To determine whether this does have beneficial effects on length of stay in hospital or on severity scores, we undertook a double-blind, randomized, controlled trial in a pediatric department of a Portuguese hospital. METHODS: Previously healthy infants, younger than 12 months, hospitalized with mild-to-moderate acute viral bronchiolitis were randomized to receive either nebulized 3% (hypertonic, HS) or 0...
April 2016: Pediatric Pulmonology
https://www.readbyqxmd.com/read/26261767/from-bronchiolitis-guideline-to-practice-a-critical-care-perspective
#20
James A Lin, Andranik Madikians
Acute viral bronchiolitis is a leading cause of admission to pediatric intensive care units, but research on the care of these critically ill infants has been limited. Pathology of viral bronchiolitis revealed respiratory obstruction due to intraluminal debris and edema of the airways and vasculature. This and clinical evidence suggest that airway clearance interventions such as hypertonic saline nebulizers and pulmonary toilet devices may be of benefit, particularly in situations of atelectasis associated with bronchiolitis...
August 4, 2015: World Journal of Critical Care Medicine
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