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hormonal imbalance

Juan Xu, Yujia Qian, Min Ye, Ziyi Fu, Xuemei Jia, Wenqu Li, Pengfei Xu, Mingming Lv, Lei Huang, Luyu Wang, Hongjie Ruan, Juan Lv
Endometrial carcinoma (EC) is the most common malignancy in women. Dispite its prevalence, the prognosis of endometrial carcinoma still relies on conventional histological type, grade and invasion information. Its morbidity is still increasing and the outcome is very poor. To the best of our knowledge, hormonal imbalance and/or molecular genetic alterations are the main cause of EC. However, the alterations of lncRNAs which accounts for approximately 4/5 of human transcripts are still poorly understood. In the present study, using the RiboArray™ Custom Array, we studied the expression profiles of lncRNA in EC as compared to normal endometrium (NE) to find potential core lncRNAs for the diagnosis of EC...
October 14, 2016: Oncology Reports
Jessica E Miller, Soo Hyun Ahn, Stephany P Monsanto, Kasra Khalaj, Madhuri Koti, Chandrakant Tayade
Endometriosis is a complex, inflammatory disease that affects 6-10% of reproductive-aged women. Almost half of the women with endometriosis experience infertility. Despite the excessive prevalence, the pathogenesis of endometriosis and its associated infertility is unknown and a cure is not available. While many theories have been suggested to link endometriosis and infertility, a consensus among investigators has not emerged. In this extensive review of the literature as well as research from our laboratory, we provide potential insights into the role of immune dysfunction in endometriosis associated infertility...
October 11, 2016: Oncotarget
Monika Chaszczewska-Markowska, Maria Sagan, Katarzyna Bogunia-Kubik
Secretion of renin juxtaglomerular cells into bloodstream initiates activation of an enzymatic-hormonal cascade known as the RAAS (renin - angiotensin - aldosterone system). As a result, blood pressure is increased by the means several interrelated mechanisms. Mechanism of Zjednoczoaction of this system has been known for decades, but a few previously unknown components were recently added, such as ACE-2 and Ang(1-7), and their role often seems to be opposite to that of the conventional components. Local tissue systems also have important biological functions...
September 13, 2016: Postȩpy Higieny i Medycyny Doświadczalnej
Erling Thom
Postpartum effluvium is a well-known clinical fact. However, following some minor research activities in the 1960s, very little has happened on the research front of the subject. It was hypothesized that postpartum hair loss might be a manifestation of a change in the hair growth cycle occurring normally during pregnancy. Recently, new research has been published trying to explain the mechanism of action behind this frequently occurring hair growth disruption, and to develop a functional treatment schedule and regime...
September 23, 2016: Journal of Cosmetic Dermatology
Froylán Vargas-Martínez, Richard J Schanler, Steven A Abrams, Keli M Hawthorne, Susan Landers, José Guzman-Bárcenas, Onofre Muñoz, Tore Henriksen, Maria Petersson, Kerstin Uvnäs-Moberg, Ismael Jiménez-Estrada
Hypertension is a major risk factor for ischemic heart disease and stroke, leading causes of morbidity and death worldwide. Intrauterine growth restriction (IUGR), caused by an excess of glucocorticoid exposure to the fetus, produces an imbalance in oxidative stress altering many biochemical and epigenetic gene transcription processes exposing the fetus and neonate to the 'thrifty' phenotype and pervasive polymorphisms appearance damaging health, cognitive, and behavioral processes in later life. OT is a major regulator of oxidative stress radicals that plays a major role in neonatal maturation of the central nervous system and many peripheral tissues expressing oxytocin/oxytocin-receptor (OT/OTR) system in the early postnatal period...
September 20, 2016: Biochimica et Biophysica Acta
Amos O Abolaji, Isaac A Adedara, Ayodeji O Abajingin, Ore J Fatunmibi, Emmanuel O Ladipo, Ebenezer O Farombi
4-Vinylcyclohexene diepoxide (VCD) is an occupational chemical widely reported to deplete ovarian follicles in rodents. Here, we investigated VCD-induced reproductive dysfunction in female Wistar rats. The rats were orally administered with VCD (100, 250 and 500mg/kg) for twenty-eight days. Thereafter, we evaluated selected biomarkers of oxidative damage, inflammation, endocrine disruption, and apoptosis. We observed that VCD increased ovarian and uterine malondialdehyde (MDA) level, and catalase, glutathione peroxidase (GPx) and glutathione S-transferase (GST) activities in rats (p<0...
September 16, 2016: Reproductive Toxicology
Seyyed Mohammad Hassan Aletayeb, Masoud Dehdashtiyan, Majid Aminzadeh, Arash Malekyan, Somayeh Jafrasteh
BACKGROUND: Neonatal jaundice is the result of an imbalance between the production and conjugation of bilirubin. Considering the multiple roles of vitamin D, lower levels of vitamin D in these cases may be associated with neonatal jaundice. The present study was undertaken for the purpose of comparing serum vitamin D levels in healthy term jaundiced and nonjaundiced newborns and their mothers. METHODS: This case-control study was conducted in 60 term newborns and their mothers from a teaching and referral children's hospital in the southwestern region of Iran, from December 22, 2013 through March 22, 2014...
September 12, 2016: Journal of the Chinese Medical Association: JCMA
A C Duarte, M V Hrynchak, I Gonçalves, T Quintela, C R A Santos
Sex hormones (SH) are essential regulators of the central nervous system (CNS). The decline in SH levels along with aging may contribute to compromised neuroprotection and for setting the grounds for neurodegeneration and cognitive impairments. In Alzheimer's Disease (AD), besides other pathological features, there is an imbalance between amyloid β (Aβ) production and clearance leading to its accumulation in the brain of older subjects. Aβ accumulation is a primary cause for brain inflammation and degeneration, and concomitant cognitive decline...
September 15, 2016: Journal of Neuroendocrinology
Shou-Qiang Zhong, Zan-Xiong Chen, Min-Li Kong, Yan-Qi Xie, Yang Zhou, Xiao-Di Qin, Gunther Paul, Xiao-Wen Zeng, Guang-Hui Dong
Little information exists about the evaluation of potential developmental immunotoxicity induced by perfluorooctane sulfonate (PFOS), a synthetic persistent and increasingly ubiquitous environmental contaminant. To assess potential sex-specific impacts of PFOS on immunological health in the offspring, using male and female C57BL/6 mice, pups were evaluated for developmental immunotoxic effects after maternal oral exposure to PFOS (0.1, 1.0 and 5.0 mg PFOS/kg/day) during Gestational Days 1-17. Spontaneous TH1/TH2-type cytokines, serum levels of testosterone and estradiol were evaluated in F1 pups at four and eight weeks of age...
2016: International Journal of Molecular Sciences
Karen P Briski, Fahaad S H Alenazi, Manita Shakya, Paul W Sylvester
Estradiol (E) mitigates acute and postacute adverse effects of 12 hr-food deprivation (FD) on energy balance. Hindbrain 5'-monophosphate-activated protein kinase (AMPK) regulates hyperphagic and hypothalamic metabolic neuropeptide and norepinephrine responses to FD in an E-dependent manner. Energy-state information from AMPK-expressing hindbrain A2 noradrenergic neurons shapes neural responses to metabolic imbalance. Here we investigate the hypothesis that FD causes divergent changes in A2 AMPK activity in E- vs...
September 12, 2016: Journal of Neuroscience Research
Ismael Valladolid-Acebes, Teresa Daraio, Kerstin Brismar, Tomas Hökfelt, Christina Bark
The exocytosis of signaling molecules from neuronal, neuroendocrine and endocrine cells is regulated by membrane fusion involving SNAP-25 and associated SNARE proteins. The importance of this process for metabolic control recently became evident by studies of mouse mutants genetically engineered to only express one of 2 closely related, alternatively-spliced variants of SNAP-25. The results showed that even minor differences in the function of proteins regulating exocytosis are sufficient to provoke metabolic disease, including hyperglycaemia, liver steatosis, adipocyte hypertrophy and obesity...
July 2016: Adipocyte
Agnese Collamati, Emanuele Marzetti, Riccardo Calvani, Matteo Tosato, Emanuela D'Angelo, Alex N Sisto, Francesco Landi
Chronic heart failure (CHF) is a highly prevalent condition among the elderly and is associated with considerable morbidity, institutionalization and mortality. In its advanced stages, CHF is often accompanied by the loss of muscle mass and strength. Sarcopenia is a geriatric syndrome that has been actively studied in recent years due to its association with a wide range of adverse health outcomes. The goal of this review is to discuss the relationship between CHF and sarcopenia, with a focus on shared pathophysiological pathways and treatments...
July 2016: Journal of Geriatric Cardiology: JGC
Amarnath Rambhatla, Jesse N Mills, Jacob Rajfer
Estradiol, normally considered a female hormone, appears to play a significant role in men in a variety of physiologic functions, such as bone metabolism, cardiovascular health, and testicular function. As such, estradiol has been targeted by male reproductive and sexual medicine specialists to help treat conditions such as infertility and hypogonadism. The compounds that modulate estradiol levels in these clinical conditions are referred to as selective estrogen receptor modulators (SERMs) and aromatase inhibitors (AIs)...
2016: Reviews in Urology
S A Povzun
A 42-year-old female body builder who had used anabolic androgenic steroids (AASs) for 18 years to build up muscle mass died from liver rupture. The cause of the latter was multiple abscesses caused by Actinomyces, which developed in the presence of immunodeficiency. The postmortem changes in different organs were due to hormonal imbalance. The paper gives the data available in the literature pertaining to the analysis of the effects of AASs taken in supraphysiological doses on the body and their non-medical application...
July 2016: Arkhiv Patologii
H A Agashe, A Y Paek, J L Contreras-Vidal
Upper limb amputation results in a severe reduction in the quality of life of affected individuals due to their inability to easily perform activities of daily living. Brain-machine interfaces (BMIs) that translate grasping intent from the brain's neural activity into prosthetic control may increase the level of natural control currently available in myoelectric prostheses. Current BMI techniques demonstrate accurate arm position and single degree-of-freedom grasp control but are invasive and require daily recalibration...
2016: Progress in Brain Research
Sultan Ayoub Meo, Asim Hassain
The metabolic physiology during pregnancy is unique in the life of women. This change is a normal physiological adaptation to better accommodate the foetal growth and provides adequate blood, nutrition and oxygen. The metabolic changes prepare the mother\'s body for pregnancy, childbirth and lactation. Early gestational period is considered as an anabolic phase, in which female body stores nutrients, enhance insulin sensitivity to encounter the maternal and feto-placental demands of late gestation and lactation...
September 2016: JPMA. the Journal of the Pakistan Medical Association
Patricia D C Schaker, Alessandra C Palhares, Lucas M Taniguti, Leila P Peters, Silvana Creste, Karen S Aitken, Marie-Anne Van Sluys, João P Kitajima, Maria L C Vieira, Claudia B Monteiro-Vitorello
Sugarcane smut disease is caused by the biotrophic fungus Sporisorium scitamineum. The disease is characterized by the development of a whip-like structure from the primary meristems, where billions of teliospores are produced. Sugarcane smut also causes tillering and low sucrose and high fiber contents, reducing cane productivity. We investigated the biological events contributing to disease symptoms in a smut intermediate-resistant sugarcane genotype by examining the transcriptional profiles (RNAseq) shortly after inoculating the plants and immediately after whip emission...
2016: PloS One
Bizhan Ziaeean, Sahar Sohrabi-Nazari
Parathyroid adenoma is a benign tumor of the parathyroid glands. The cause of most parathyroid adenomas is unknown. Parathyroid adenoma increases the secretion of parathyroid hormone and results in primary hyperparathyroidism. High amounts of parathyroid hormone in the blood cause the imbalance of calcium, which leads to various complications such as kidney stones, depression, lethargy, nausea, vomiting, abdominal pain, myalgia, bone and joint pain, hoarseness, etc. Oropharyngeal dysphagia is defined as having problem in swallowing due to abnormalities in the structure and function of oropharynx and other related organs...
September 2016: Iranian Journal of Medical Sciences
Sultan Ayoub Meo, Asim Hassain
The metabolic physiology during pregnancy is unique in the life of women. This change is a normal physiological adaptation to better accommodate the foetal growth and provides adequate blood, nutrition and oxygen. The metabolic changes prepare the mother\'s body for pregnancy, childbirth and lactation. Early gestational period is considered as an anabolic phase, in which female body stores nutrients, enhance insulin sensitivity to encounter the maternal and feto-placental demands of late gestation and lactation...
September 2016: JPMA. the Journal of the Pakistan Medical Association
Lluis Campins, Marcella Camps, Ariadna Riera, Eulogio Pleguezuelos, Juan Carlos Yebenes, Mateu Serra-Prat
Sarcopenia is a geriatric syndrome characterized by progressive and generalized loss of skeletal muscle mass and function. Reported prevalence of this geriatric syndrome, differs depending on the definition, the population and the method used to identify sarcopenia. The causes of sarcopenia are multifactorial, and can include genetic influence, immobility or disuse, endocrine factors, inflammation and nutritional deficiencies. These disorders involve an imbalance between anabolic and catabolic pathways that rules muscle mass...
August 31, 2016: Pharmacology
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