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JOURNAL ARTICLE
Asaf E Evren, Demokrat Nuha, Begüm N S Özkan, Çiğdem Kahraman, Ekrem M Gönülalan, Leyla Yurttaş
This study examines the synthesis and evaluation of 11 newly developed compounds as potential anti-Alzheimer's agents that occur via cholinesterase and β-secretase inhibition. The compounds were tested for their inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) using the modified Ellman method. The results showed that several compounds exhibited significant inhibition of AChE, particularly compounds 6d, 7a, and 7e, which demonstrated high inhibitory activity at lower concentrations, with IC50 values of 0...
April 24, 2024: Archiv der Pharmazie
#2
JOURNAL ARTICLE
Danzhou Fang, Zhiming Zhou, Yalan Xiong, Yongzeng Fan, Yixuan Li, Huayi Zhao, Jiahui Huang, Gengbiao Yuan, Maohua Rao
OBJECTIVE: Alzheimer's disease, an irreversible neurological condition, demands timely diagnosis for effective clinical intervention. This study employs radiomics analysis to assess image features in default mode network cerebral perfusion imaging among individuals with cognitive impairment. METHODS: A radiomics analysis of cerebral perfusion imaging was conducted on 117 patients with cognitive impairment. They were divided into training and validation sets in a 7:3 ratio...
April 24, 2024: Journal of Applied Clinical Medical Physics
#3
JOURNAL ARTICLE
Jiaxing Xu, Qingtian Bian, Xinhang Li, Aihu Zhang, Yiping Ke, Miao Qiao, Wei Zhang, Wei Khang Jeremy Sim, Balazs Gulyas
Functional magnetic resonance imaging (fMRI) is a commonly used technique to measure neural activation. Its application has been particularly important in identifying underlying neurodegenerative conditions such as Parkinson's, Alzheimer's, and Autism. Recent analysis of fMRI data models the brain as a graph and extracts features by graph neural networks (GNNs). However, the unique characteristics of fMRI data require a special design of GNN. Tailoring GNN to generate effective and domain-explainable features remains challenging...
April 24, 2024: IEEE Transactions on Medical Imaging
#4
REVIEW
Shichan Wang, Xiaoting Zheng, Jingxuan Huang, Jiyong Liu, Chunyu Li, Huifang Shang
BACKGROUND: Alzheimer's disease (AD) is on the rise in our aging society, making it crucial to identify additional risk factors to mitigate its increasing incidence. This systematic review and meta-analysis aimed to provide updated evidence regarding the association between sleep and AD. METHODS: We conducted a comprehensive search of MEDLINE, EMBASE, and Web of Science databases from inception to July 2023 to identify longitudinal studies. Adjusted relative risks were pooled for each sleep characteristic, and a dose-response analysis was performed specifically for sleep duration...
April 24, 2024: Journal of Neurology
#5
JOURNAL ARTICLE
Teresa J Kelechi, Diana Layne, Martina Mueller, Mohan Madisetti, Sundaravadivel Balasubramanian
BACKGROUND: Mind-body interventions focused on intentional breathing and movement have been found to mitigate the negative effects of caregiving such as such as stress, psychosocial distress, and emotional distress associated for persons living with Alzheimer's disease and related dementias. OBJECTIVE: The objective was to assess the feasibility and acceptability and preliminary impacts of our 12-week mind body intervention "Gentle Yoga and Yogic Breathing" for caregivers of persons living with dementia on health outcomes including mutuality, depression and anxiety, loneliness and social support, quality of life, and physical function...
April 24, 2024: Western Journal of Nursing Research
#6
JOURNAL ARTICLE
Helena Temkin-Greener, Yechu Hua, Shubing Cai
BACKGROUND: Little is known about mental health among Medicare beneficiaries with Alzheimer's disease or related dementias (ADRD) who reside in assisted living (AL) communities. The COVID-19 pandemic may have curtailed ambulatory care access for these residents, but telehealth may have expanded it. We examined in-person and telehealth use of ambulatory mental health visits among AL residents with ADRD, pre and during the COVID pandemic, focusing on race/ethnicity and Medicare/Medicaid dual status...
April 24, 2024: Journal of the American Geriatrics Society
#7
JOURNAL ARTICLE
Lisa V Graves, Wassim Tarraf, Kevin Gonzalez, Mark W Bondi, Linda C Gallo, Carmen R Isasi, Martha Daviglus, Melissa Lamar, Donglin Zeng, Jianwen Cai, Hector M González
INTRODUCTION: We investigated cognitive profiles among diverse, middle-aged and older Hispanic/Latino adults in the Study of Latinos-Investigation of Neurocognitive Aging (SOL-INCA) cohort using a cross-sectional observational study design. METHODS: Based on weighted descriptive statistics, the average baseline age of the target population was 56.4 years, slightly more than half were women (54.6%), and 38.4% reported less than a high school education. We used latent profile analysis of demographically adjusted z scores on SOL-INCA neurocognitive tests spanning domains of verbal memory, language, processing speed, and executive function...
2024: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
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JOURNAL ARTICLE
Farzaneh Yazdanpanah, Alun C Jackson, Neda Sanaie, Farshad Sharifi, Seyed Morteza Shamshirgaran, Fatemeh Bahramnezhad
BACKGROUND AND AIMS: The COVID-19 pandemic and the infection of numerous individuals from diverse societies have emerged as major global challenges. Given the limited resources in intensive care units, effective bed management and resource allocation require a deep understanding of the disease. This study aimed to assess the epidemiology and treatment outcomes of COVID-19 patients admitted to an intensive care unit in an Iranian hospital in Neyshabur city. METHODS: This cross-sectional study was conducted on COVID-19 patients hospitalized in intensive care units in Razavi Khorasan, Iran in 2021...
April 2024: Health Science Reports
#9
EDITORIAL
Alexandra Wolf, Karine Ravienna, Elena Salobrar-Garcia
No abstract text is available yet for this article.
2024: Frontiers in Psychology
#10
JOURNAL ARTICLE
Haodong Wang, Quefeng Li, Yufeng Liu
Multi-modal data are prevalent in many scientific fields. In this study, we consider the parameter estimation and variable selection for a multi-response regression using block-missing multi-modal data. Our method allows the dimensions of both the responses and the predictors to be large, and the responses to be incomplete and correlated, a common practical problem in high-dimensional settings. Our proposed method uses two steps to make a prediction from a multi-response linear regression model with block-missing multi-modal predictors...
April 2024: Statistica Sinica
#11
JOURNAL ARTICLE
Koji Inui, Nobuyuki Takeuchi, Bayasgalan Borgil, Megumi Shingaki, Shunsuke Sugiyama, Tomoya Taniguchi, Makoto Nishihara, Takayasu Watanabe, Dai Suzuki, Eishi Motomura, Tetsuo Kida
Responses to a sensory stimulus are inhibited by a preceding stimulus; if the two stimuli are identical, paired-pulse suppression (PPS) occurs; if the preceding stimulus is too weak to reliably elicit the target response, prepulse inhibition (PPI) occurs. PPS and PPI represent excitability changes in neural circuits induced by the first stimulus, but involve different mechanisms and are impaired in different diseases, e.g., impaired PPS in schizophrenia and Alzheimer's disease and impaired PPI in schizophrenia and movement disorders...
2024: Frontiers in Neuroscience
#12
JOURNAL ARTICLE
Rosaleena Mohanty, Daniel Ferreira, Eric Westman
INTRODUCTION: Heterogeneity in downstream atrophy in Alzheimer's disease (AD) is predominantly investigated in relation to pathological hallmarks (Aβ, tau) and co-pathologies (cerebrovascular burden) independently. However, the proportional contribution of each pathology in determining atrophy pattern remains unclear. We assessed heterogeneity in atrophy using two recently conceptualized dimensions: typicality (typical AD atrophy at the center and deviant atypical atrophy on either extreme including limbic predominant to hippocampal sparing patterns) and severity (overall neurodegeneration spanning minimal atrophy to diffuse typical AD atrophy) in relation to Aβ, tau, and cerebrovascular burden...
2024: Frontiers in Neuroscience
#13
JOURNAL ARTICLE
Assunta Ingannato, Silvia Bagnoli, Salvatore Mazzeo, Giulia Giacomucci, Valentina Bessi, Camilla Ferrari, Sandro Sorbi, Benedetta Nacmias
BACKGROUND: Plasma biomarkers are preferable to invasive and expensive diagnostic tools, such as neuroimaging and lumbar puncture that are gold standard in the clinical management of Alzheimer's Disease (AD). Here, we investigated plasma Glial Fibrillary Acidic Protein (GFAP), Neurofilament Light Chain (NfL) and Phosphorylated-tau-181 (pTau 181) in AD and in its early stages: Subjective cognitive decline (SCD) and Mild cognitive impairment (MCI). MATERIAL AND METHODS: This study included 152 patients (42 SCD, 74 MCI and 36 AD)...
2024: Frontiers in Endocrinology
#14
Radhika Joshi, Veronika Brezani, Gabrielle M Mey, Sergi Guixé-Muntet, Marti Ortega-Ribera, Yuan Zhuang, Adam Zivny, Sebastian Werneburg, Jordi Gracia-Sancho, Gyongyi Szabo
The pathological role of interferon signaling is emerging in neuroinflammatory disorders, yet, the specific role of Interferon Regulatory Factor 3 (IRF3) in neuroinflammation remains poorly understood. Here, we show that global IRF3 deficiency delays TLR4-mediated signaling in microglia and attenuates the hallmark features of LPS-induced inflammation such as cytokine release, microglial reactivity, astrocyte activation, myeloid cell infiltration, and inflammasome activation. Moreover, expression of a constitutively active IRF3 (S388D/S390D:IRF3-2D) in microglia induces a transcriptional program reminiscent of the Activated Response Microglia and the expression of genes associated with Alzheimer's Disease, notably apolipoprotein-e ...
March 12, 2024: bioRxiv
#15
JOURNAL ARTICLE
Ananya Srivastava, Gautam Kumar, Prabhat Kumar, S Srikrishna, Pranjal Chandra, Vinod P Singh
A thiazole-based probe, N '-((2-aminothiazol-5-yl)methylene)benzohydrazide ( TBH ), has been efficiently synthesized and characterized for the selective and sensitive detection of the neurotransmitter epinephrine (EP). The sensing strategy is based on the use of TBH for sequential colorimetric sensing of Ag+ and EP via in situ formation of Ag nanoparticles (Ag NPs) from the TBH -Ag+ complex. The generated Ag NPs lead to a bathochromic shift in absorption maximum and a change in color of the solution from light brown to reddish brown...
April 23, 2024: ACS Applied Bio Materials
#16
JOURNAL ARTICLE
Hannah Baumeister, Jacob W Vogel, Philip S Insel, Luca Kleineidam, Steffen Wolfsgruber, Melina Stark, Helena M Gellersen, Renat Yakupov, Matthias C Schmid, Falk Lüsebrink, Frederic Brosseron, Gabriel Ziegler, Silka D Freiesleben, Lukas Preis, Luisa-Sophie Schneider, Eike J Spruth, Slawek Altenstein, Andrea Lohse, Klaus Fliessbach, Ina R Vogt, Claudia Bartels, Björn H Schott, Ayda Rostamzadeh, Wenzel Glanz, Enise I Incesoy, Michaela Butryn, Daniel Janowitz, Boris-Stephan Rauchmann, Ingo Kilimann, Doreen Goerss, Matthias H Munk, Stefan Hetzer, Peter Dechent, Michael Ewers, Klaus Scheffler, Anika Wuestefeld, Olof Strandberg, Danielle van Westen, Niklas Mattsson-Carlgren, Shorena Janelidze, Erik Stomrud, Sebastian Palmqvist, Annika Spottke, Christoph Laske, Stefan Teipel, Robert Perneczky, Katharina Buerger, Anja Schneider, Josef Priller, Oliver Peters, Alfredo Ramirez, Jens Wiltfang, Michael T Heneka, Michael Wagner, Emrah Düzel, Frank Jessen, Oskar Hansson, David Berron
Memory clinic patients are a heterogeneous population representing various aetiologies of pathological aging. It is unknown if divergent spatiotemporal progression patterns of brain atrophy, as previously described in Alzheimer's disease (AD) patients, are prevalent and clinically meaningful in this group of older adults. To uncover distinct atrophy subtypes, we applied the Subtype and Stage Inference (SuStaIn) algorithm to baseline structural MRI data from 813 participants enrolled in the DELCODE cohort (mean ± SD age = 70...
April 24, 2024: Brain
#17
JOURNAL ARTICLE
Yong Peng, Quan Chen, Ya-Hui Xue, Hong Jin, Shu Liu, Miao-Qiao Du, Shun-Yu Yao
The pathogenesis of Alzheimer's disease (AD), a degenerative disease of the central nervous system, remains unclear. The main manifestations of AD include cognitive and behavioral disorders, neuropsychiatric symptoms, neuroinflammation, amyloid plaques, and neurofibrillary tangles. However, current drugs for AD once the dementia stage has been reached only treat symptoms and do not delay progression, and the research and development of targeted drugs for AD have reached a bottleneck. Thus, other treatment options are needed...
April 24, 2024: American Journal of Chinese Medicine
#18
JOURNAL ARTICLE
Rafaela Morais-Ribeiro, Francisco C Almeida, Ana Coelho, Tiago Gil Oliveira
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that primarily affects the hippocampus. Since hippocampal studies have highlighted a differential subregional regulation along its longitudinal axis, a more detailed analysis addressing subregional changes along the longitudinal hippocampal axis has the potential to provide new relevant biomarkers. This study included structural brain MRI data of 583 participants from the Alzheimer's Disease Neuroimaging Initiative (ADNI). Cognitively normal (CN) subjects, mild cognitively impaired (MCI) subjects and AD patients were conveniently selected considering the age and sex match between clinical groups...
April 23, 2024: European Journal of Neuroscience
#19
JOURNAL ARTICLE
Hao Chen, Jin Hu, Shiqi Gui, Qiushuo Li, Jing Wang, Xing Yang, Jingyuan Yang
BACKGROUND: While evidence supports cognitive reserve (CR) in preserving cognitive function, longitudinal validation of CR proxies, including later-life factors, remains scarce. This study aims to validate CR's stability over time and its relation to cognitive function in rural Chinese older adults. METHODS: Within the project on the health status of rural older adults (HSRO), the survey included baseline assessment (2019) and follow-up assessment (2022). 792 older adults (mean age: 70...
April 23, 2024: Alzheimer's Research & Therapy
#20
JOURNAL ARTICLE
Lina Vandermeulen, Ivana Geric, Laura Fumagalli, Mohamed Kreir, Ashley Lu, Annelies Nonneman, Jessie Premereur, Leen Wolfs, Rafaela Policarpo, Nicola Fattorelli, An De Bondt, Ilse Van Den Wyngaert, Bob Asselbergh, Mark Fiers, Bart De Strooper, Constantin d'Ydewalle, Renzo Mancuso
BACKGROUND: Microglia play important roles in maintaining brain homeostasis and neurodegeneration. The discovery of genetic variants in genes predominately or exclusively expressed in myeloid cells, such as Apolipoprotein E (APOE) and triggering receptor expressed on myeloid cells 2 (TREM2), as the strongest risk factors for Alzheimer's disease (AD) highlights the importance of microglial biology in the brain. The sequence, structure and function of several microglial proteins are poorly conserved across species, which has hampered the development of strategies aiming to modulate the expression of specific microglial genes...
April 24, 2024: Molecular Neurodegeneration
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