keyword
https://read.qxmd.com/read/38531711/roles-of-the-tubulin-based-cytoskeleton-in-the-toxoplasma-gondii-apical-complex
#1
REVIEW
Albert Tell I Puig, Dominique Soldati-Favre
Microtubules (MTs) play a vital role as key components of the eukaryotic cytoskeleton. The phylum Apicomplexa comprises eukaryotic unicellular parasitic organisms defined by the presence of an apical complex which consists of specialized secretory organelles and tubulin-based cytoskeletal elements. One apicomplexan parasite, Toxoplasma gondii, is an omnipresent opportunistic pathogen with significant medical and veterinary implications. To ensure successful infection and widespread dissemination, T. gondii heavily relies on the tubulin structures present in the apical complex...
March 25, 2024: Trends in Parasitology
https://read.qxmd.com/read/38508901/exploiting-integrative-metabolomics-to-study-host-parasite-interactions-in-plasmodium-infections
#2
REVIEW
Maria Nikulkova, Wael Abdrabou, Jane M Carlton, Youssef Idaghdour
Despite years of research, malaria remains a significant global health burden, with poor diagnostic tests and increasing antimalarial drug resistance challenging diagnosis and treatment. While 'single-omics'-based approaches have been instrumental in gaining insight into the biology and pathogenicity of the Plasmodium parasite and its interaction with the human host, a more comprehensive understanding of malaria pathogenesis can be achieved through 'multi-omics' approaches. Integrative methods, which combine metabolomics, lipidomics, transcriptomics, and genomics datasets, offer a holistic systems biology approach to studying malaria...
March 19, 2024: Trends in Parasitology
https://read.qxmd.com/read/38499920/development-of-new-pcr-protocols-to-detect-genetic-diversity-in-the-metronidazole-metabolism-genes-in-susceptible-and-refractory-clinical-samples-of-giardia-duodenalis
#3
JOURNAL ARTICLE
Ali Asghari, Farzad Mahdavi, Amirhosein Yousefi, Laya Shamsi, Roya Badali, Mohammad Reza Mohammadi, Hamid Irannejad, Behnam Mohammadi-Ghalehbin, Saeed Shahabi, Qasem Asgari, Mohammad Hossein Motazedian, Saiyad Bastaminejad
PURPOSE: Investigating the genetic variation in thioredoxin reductase (TrxR) and nitroreductase (NR) genes in both treatment-resistant and -sensitive Giardia duodenalis isolates can provide valuable information in identifying potential markers of resistance to metronidazole. The rapid increase in metronidazole treatment failures suggests the presence of genetic resistance mechanisms. By analyzing these genes, researchers can gain insights into the efficacy of metronidazole against G. duodenalis and potentially develop alternative treatment strategies...
March 18, 2024: Acta Parasitologica
https://read.qxmd.com/read/38468018/two-new-genera-and-species-of-the-parasitic-copepod-family-chondracanthidae-milne-edwards-1840-copepoda-cyclopoida-from-deep-sea-fishes-off-suruga-bay-japan
#4
JOURNAL ARTICLE
Panakkool Thamban Aneesh, Susumu Ohtsuka, Yusuke Kondo, Ameri Kottarathil Helna
PURPOSE: The present paper describes two new genera and species of the parasitic copepod family Chondracanthidae Milne Edwards, 1840 based on specimens collected from two species of deep-sea fishes at a depth of 212 m off Suruga Bay, Japan. Avatar nishidai gen. et sp. nov. is described from the host fish Chaunax abei Le Danois, 1978 (Chaunacidae). Kokeshioides surugaensis gen. et sp. nov. is described from the host fish Setarches longimanus (Alcock, 1894) (Setarchidae). METHODS: Fresh specimens of chondracanthids were collected from the buccal cavity of two species of deep-sea fishes (fish hosts were frozen), Chaunax abei Le Danois, 1978 (Lophiiformes: Chaunacidae) and Setarches longimanus (Alcock, 1894) (Perciformes: Setarchidae), caught at a depth of 212 m in Suruga Bay, Japan (34° 37'48...
March 11, 2024: Acta Parasitologica
https://read.qxmd.com/read/38466806/glycolytic-enzymes-as-vaccines-against-schistosomiasis-testing-schistosoma-mansoni-phosphoglycerate-mutase-in-mice
#5
JOURNAL ARTICLE
David B Pirovich, Akram A Da'dara, Patrick J Skelly
Schistosomiasis is a globally burdensome parasitic disease caused by flatworms (blood flukes) in the genus Schistosoma. The current standard treatment for schistosomiasis is the drug praziquantel, but there is an urgent need to advance novel interventions such as vaccines. Several glycolytic enzymes have been evaluated as vaccine targets for schistosomiasis, and data from these studies are reviewed here. Although these parasites are canonically considered to be intracellular, proteomic analysis has revealed that many schistosome glycolytic enzymes are additionally found at the host-interactive surface...
March 1, 2024: Journal of Parasitology
https://read.qxmd.com/read/38448148/getting-around-the-roundworms-identifying-knowledge-gaps-and-research-priorities-for-the-ascarids
#6
JOURNAL ARTICLE
Adrian J Wolstenholme, Erik C Andersen, Shivani Choudhary, Friederike Ebner, Susanne Hartmann, Lindy Holden-Dye, Sudhanva S Kashyap, Jürgen Krücken, Richard J Martin, Ankur Midha, Peter Nejsum, Cedric Neveu, Alan P Robertson, Georg von Samson-Himmelstjerna, Robert Walker, Jianbin Wang, Bradley J Whitehead, Paul D E Williams
The ascarids are a large group of parasitic nematodes that infect a wide range of animal species. In humans, they cause neglected diseases of poverty; many animal parasites also cause zoonotic infections in people. Control measures include hygiene and anthelmintic treatments, but they are not always appropriate or effective and this creates a continuing need to search for better ways to reduce the human, welfare and economic costs of these infections. To this end, Le Studium Institute of Advanced Studies organized a two-day conference to identify major gaps in our understanding of ascarid parasites with a view to setting research priorities that would allow for improved control...
2024: Advances in Parasitology
https://read.qxmd.com/read/38448147/parasites-in-ancient-egypt-and-nubia-malaria-schistosomiasis-and-the-pharaohs
#7
JOURNAL ARTICLE
Piers D Mitchell
The civilizations of ancient Egypt and Nubia played a key role in the cultural development of Africa, the Near East, and the Mediterranean world. This study explores how their location along the River Nile, agricultural practices, the climate, endemic insects and aquatic snails impacted the type of parasites that were most successful in their populations. A meta-analysis approach finds that up to 65% of mummies were positive for schistosomiasis, 40% for headlice, 22% for falciparum malaria, and 10% for visceral leishmaniasis...
2024: Advances in Parasitology
https://read.qxmd.com/read/38448146/a-review-of-health-education-activities-targeting-schoolchildren-for-the-control-of-soil-transmitted-helminthiasis-in-southeast-asia-with-emphasis-upon-the-magic-glasses-approach
#8
JOURNAL ARTICLE
Mary Lorraine S Mationg, Gail M Williams, Veronica L Tallo, Remigio M Olveda, Donald P McManus, Donald E Stewart, Darren J Gray
Soil-transmitted helminths continue to be a serious problem causing disease and morbidity globally. Children, mostly school-aged, are more at risk of these infections. The main strategy for control remains to be the mass drug administration (MDA) of antihelminthic drugs. With the limitation of MDA to prevent re-infection, the need for additional approaches such as hygiene education and improvements in water, sanitation and hygiene (WASH) infrastructure are required. Although the importance of health education as a crucial component of an integrated approaches to STH control is highlighted, this component has often been disregarded because the other more complex solutions have been the focus of most studies and programmes...
2024: Advances in Parasitology
https://read.qxmd.com/read/38443305/insects-essential-role-in-understanding-and-broadening-animal-medication
#9
REVIEW
Silvio Erler, Sheena C Cotter, Dalial Freitak, Hauke Koch, Evan C Palmer-Young, Jacobus C de Roode, Angela M Smilanich, H Michael G Lattorff
Like humans, animals use plants and other materials as medication against parasites. Recent decades have shown that the study of insects can greatly advance our understanding of medication behaviors. The ease of rearing insects under laboratory conditions has enabled controlled experiments to test critical hypotheses, while their spectrum of reproductive strategies and living arrangements - ranging from solitary to eusocial communities - has revealed that medication behaviors can evolve to maximize inclusive fitness through both direct and indirect fitness benefits...
March 4, 2024: Trends in Parasitology
https://read.qxmd.com/read/38422764/the-first-report-of-triple-anthelmintic-resistance-on-a-french-thoroughbred-stud-farm
#10
JOURNAL ARTICLE
Aurélie Merlin, Nicolas Larcher, José-Carlos Vallé-Casuso
This study assessed the anthelmintic resistance in strongylid nematodes against commonly used anthelmintic (AH) drugs in a French galloping racehorse stud farm from March to December 2023. Faecal egg count reduction tests (FECRTs) were conducted in three different groups of Thoroughbred yearlings (a group of 6 males, a group of 13 females and a group of 8 females and 3 males) following the new World Association for the Advancement of Veterinary Parasitology (WAAVP) guidelines. The efficacy of fenbendazole was tested in two groups once during the monitoring period (in March), the efficacy of ivermectin in 3 groups twice (in March-April and in November-December) and the efficacy of pyrantel in one group once (in May-June)...
February 23, 2024: International Journal for Parasitology, Drugs and Drug Resistance
https://read.qxmd.com/read/38417928/assessment-of-the-role-of-gut-health-in-childhood-stunting-in-a-multisite-longitudinal-study-in-india-indonesia-and-senegal-a-ukri-gcrf-action-against-stunting-hub-protocol
#11
JOURNAL ARTICLE
Benjamin Momo Kadia, Anouschka S Ramsteijn, Teena Dasi, Umi Fahmida, Bharati Kulkarni, Babacar Faye, Min Kyaw Htet, Doudou Sow, Rajender Rao Kalashikam, Ritu Sharma, Arienta R P Sudibya, Sari Kusuma, Tiffany C Angelin, Mifa Nurfadilah, Modou Lamin Jobarteh, Ndeye Sokhna Diop, Isobel Gabain, Beatriz Calvo-Urbano, Elaine Ferguson, Paul Haggarty, Claire Heffernan, Joanne P Webster, Alan W Walker, Stephen Allen
INTRODUCTION: Childhood stunting has a complex aetiology, with poor gut health being an important contributor. This study will assess inter-relationships between maternal and infant gut health indices and infant linear growth. Inter-relationships between gut health indices, systemic inflammation and growth hormones in early childhood will also be assessed. METHODS AND ANALYSIS: A longitudinal observational study of cohorts of 600 newborns and their mothers in India, Indonesia and Senegal will be conducted...
February 27, 2024: BMJ Paediatrics Open
https://read.qxmd.com/read/38409043/parsco-celebrating-10%C3%A2-years-of-a-unique-parasitology-summer-course
#12
EDITORIAL
Filipe Dantas-Torres, Marcos Antonio Bezerra-Santos, Jairo Alfonso Mendoza-Roldan, Riccardo Paolo Lia, Livia Perles, Juan Pedro Barrera, Renata Fagundes-Moreira, Mariaelisa Carbonara, Antonio Varcasia, Emanuele Brianti, Georgiana Deak, Alicia Rojas, Guadalupe Miró, Petr Volf, Gad Baneth, Domenico Otranto
ParSCo (Parasitology Summer Course) is an intense, 1-week-long summer course organized by the Parasitology Unit of the Department of Veterinary Medicine, University of Bari, Italy, with the support of the World Association for the Advancement of Veterinary Parasitology (WAAVP), the European Veterinary Parasitology College (EVPC) and Parasites and Vectors. The course, which is conducted in southern Italy, is planned for parasitologists and post-graduate students working in the field of parasitology. The course consists of theoretical and practical lessons, which include the collection, identification and diagnosis of parasites of pets, livestock and wildlife...
February 26, 2024: Parasites & Vectors
https://read.qxmd.com/read/38334208/epigenetic-changes-induced-by-parasitic-worms-and-their-excretory-secretory-products
#13
JOURNAL ARTICLE
William Harnett, Margaret M Harnett
Parasitic worms are pathogens of major medical and veterinary importance. They have evolved highly effective and sophisticated strategies of immune system manipulation, typically involving actively excreted/secreted (E-S) products. These molecules dampen and regulate the host immune responses that would otherwise result in parasite expulsion, thereby enabling the worms to survive in the host for many years, and they can also help prevent the potentially serious tissue damage that the worms can induce. Reflecting these E-S product-associated anti-inflammatory activities, there is also increasing evidence that parasitic worms and their products may serendipitously protect against allergic and autoimmune conditions and in addition, comorbidities of ageing that are associated with inflammatory responses, like type 2 diabetes and obesity...
February 9, 2024: Biochemical Society Transactions
https://read.qxmd.com/read/38308835/oral-parasitic-protozoan-entamoeba-gingivalis-in-periodontal-disease-patients-northeastern-thailand
#14
JOURNAL ARTICLE
A Boonsuya, P Chitpitaklert, P Pechdee, W Srithongklang, C Thanchonnang, N La, C N Gordon, N K Rattanapitoon, P Arunsan, S K Rattanapitoon
Entamoeba gingivalis is present in the oral cavity of humans and is associated with periodontal disease. Consequently, this study aimed to comprehensively investigate the E. gingivalis infection and the associated risk factors among individuals suffering from periodontal conditions. A cross-sectional descriptive study was carried out within a cohort of periodontal patients. Dental plaque specimens were meticulously collected and subsequently subjected to thorough examination using the polymerase chain reaction (PCR)-based technique targeting the small subunit ribosomal RNA (SrRNA) gene of the organism...
December 1, 2023: Tropical Biomedicine
https://read.qxmd.com/read/38278688/snail-microbiota-and-snail-schistosome-interactions-axenic-and-gnotobiotic-technologies
#15
REVIEW
Xi Sun, Jinni Hong, Tao Ding, Zhongdao Wu, Datao Lin
The microbiota in the intermediate snail hosts of human schistosomes can significantly affect host biology. For decades, researchers have developed axenic snails to manipulate the symbiotic microbiota. This review summarizes the characteristics of symbiotic microbes in intermediate snail hosts and describes their interactions with snails, affecting snail growth, development, and parasite transmission ability. We focus on advances in axenic and gnotobiotic technologies for studying snail-microbe interactions and exploring the role of microbiota in snail susceptibility to Schistosoma infection...
January 25, 2024: Trends in Parasitology
https://read.qxmd.com/read/38277403/gastrointestinal-parasite-infections-in-nepalese-gurkha-recruits-arriving-in-the-united-kingdom-from-2012-2020
#16
JOURNAL ARTICLE
William D Nevin, Jayne Jones, Donna Tupper, James A T Dunbar, Duncan Wilson, David Ross, Stephen Woolley, James Dodd, Jason Biswas, Lucy Lamb, Nicholas J Beeching, Matthew K O'Shea, Thomas E Fletcher
BACKGROUND: Gastrointestinal parasite (GIP) infections are a major cause of global morbidity, infecting hundreds of millions of people each year and potentially leading to lifelong infection and serious complications. Few data exist on screening for GIP infections in migrants entering the UK or on the current performance of different traditional diagnostic approaches. This study aimed to describe the prevalence of GIP infections in Nepalese Gurkha recruits screened on arrival in the UK...
January 26, 2024: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/38257871/recent-progress-in-the-detection-of-surra-a-neglected-disease-caused-by-trypanosoma-evansi-with-a-one-health-impact-in-large-parts-of-the-tropic-and-sub-tropic-world
#17
REVIEW
Jeongmin Kim, Andrés Álvarez-Rodríguez, Zeng Li, Magdalena Radwanska, Stefan Magez
Surra is a wasting disease triggered by infection with Trypanosoma evansi , a protozoan blood parasite that causes mortality and morbidity in a broad spectrum of wild and domestic animals and occasionally humans. Trypanosoma evansi has the widest geographical spread among all pathogenic trypanosomes, inflicting significant worldwide economic problems due to its adverse effects on meat and milk production. For diagnosis, most endemic countries continue to rely on traditional parasitological and serological techniques, such as the analysis of blood smears by microscopy and the Card Agglutination Test for T...
December 26, 2023: Microorganisms
https://read.qxmd.com/read/38133827/ileal-inflammation-is-reduced-due-to-treatment-with-a-metalloprotease-from-bmoomp-%C3%AE-i-snake-venom-in-an-experimental-model-of-toxoplasma-gondii-infection
#18
JOURNAL ARTICLE
Tamires Lopes Silva, Carolina Salomão Lopes, Maraisa Cristina Silva, Flávia Batista Ferreira, Heber Leão Silva Barros, Mariana Ferreira Silva, Neide Maria Silva, Fabio Oliveira, Tiago Wilson Patriarca Mineo, José Roberto Mineo
The selection process for advanced therapies in patients with inflammatory bowel diseases (IBDs) must prioritize safety, especially when considering new biologic agents or oral molecule modulators. In C57BL/6 mice, oral infection with Toxoplasma gondii induces intestinal inflammation through excessive tumor necrosis factor (TNF) production, making TNF neutralization a potential therapeutic intervention. Considering this, the present study aimed to evaluate the therapeutic effects of BmooMP-α-I, a snake venom metalloprotease isolated from Bothrops moojeni, which could promote TNF hydrolysis, in treating T...
December 22, 2023: Parasitology Research
https://read.qxmd.com/read/38127288/recent-advances-in-crispr-cas9-mediated-genome-editing-in-leishmania-strains
#19
REVIEW
Afshin Abdi Ghavidel, Shahin Aghamiri, Pourya Raee, Samira Mohammadi-Yeganeh, Effat Noori, Mojgan Bandehpour, Bahram Kazemi, Vahid Jajarmi
BACKGROUND: Genome manipulation of Leishmania species and the creation of modified strains are widely employed strategies for various purposes, including gene function studies, the development of live attenuated vaccines, and the engineering of host cells for protein production. OBJECTIVE: Despite the introduction of novel manipulation approaches like CRISPR/Cas9 technology with significant advancements in recent years, the development of a reliable protocol for efficiently and precisely altering the genes of Leishmania strains remains a challenging endeavor...
December 21, 2023: Acta Parasitologica
https://read.qxmd.com/read/38087868/advances-in-the-axenic-isolation-methods-of-blastocystis-sp-and-their-applications
#20
REVIEW
Xuefang Mei, Lai Wei, Changwei Su, Zhenke Yang, Xiaowei Tian, Zhenchao Zhang, Shuai Wang
No abstract text is available yet for this article.
December 13, 2023: Parasitology
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