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https://www.readbyqxmd.com/read/29150410/lung-function-in-early-adulthood-and-health-in-later-life-a-transgenerational-cohort-analysis
#1
Alvar Agustí, Guillaume Noell, Josep Brugada, Rosa Faner
BACKGROUND: Early life events can affect health in later life. We hypothesised that low lung function (FEV1 <80% predicted) in early adulthood (25-40 years) is associated with higher prevalence and earlier incidence of respiratory, cardiovascular, and metabolic abnormalities, and premature death. METHODS: In this cohort analysis, we tested this hypothesis using data from the Framingham Offspring Cohort (FOC) and validated our observations in CARDIA (an independent cohort) and GenIII (which includes the direct descendants of FOC participants)...
November 14, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29128908/cetuximab-tpf-radiotherapy-in-oesophageal-cancer
#2
Maria Alsina, Fernando Rivera, Francisco Javier Ramos, Maica Galán, Rafael López, Pilar García-Alfonso, José Enrique Alés-Martinez, Bernardo Queralt, Antonio Antón, Alfredo Carrato, Cristina Grávalos, Maria José Méndez-Vidal, Carlos López, Inmaculada Ruiz de Mena, Josep Tabernero, Jordi Giralt, Enrique Aranda
BACKGROUND: Pre-operative chemoradiotherapy using a 5-fluorouracil (5-FU)/cisplatin backbone is widely used to improve surgical outcomes in locoregional oesophageal cancer patients, despite a non-negligible failure rate. OBJECTIVE: We evaluated intensification of this approach to improve patient outcomes by adding cetuximab to induction 5-FU/cisplatin/docetaxel (TPF) and to chemoradiotherapy in a phase II study. PATIENTS AND METHODS: Between November 2006 and April 2009, 50 patients with stage II-IVa squamous cell carcinoma (SCC) or adenocarcinoma of the oesophagus or gastro-oesophageal junction initiated three TPF/cetuximab cycles...
November 11, 2017: Targeted Oncology
https://www.readbyqxmd.com/read/29108720/main-information-requests-of-family-members-of-patients-in-intensive-care-units
#3
J M Velasco Bueno, A Alonso-Ovies, G Heras La Calle, C Zaforteza Lallemand
OBJECTIVE: To compile an inventory of information requests prioritized by the family members, to find out which professionals them consider able to respond these requests, and to explore the differences in perception between family members and professionals. DESIGN: Qualitative analysis of content validation and descriptive cross-sectional study. SCOPE: 41 Spanish ICU. PARTICIPANTS: Relatives, physicians and nurses of critical patients...
November 3, 2017: Medicina Intensiva
https://www.readbyqxmd.com/read/29102054/cognitive-function-in-patients-on-androgen-suppression-a-prospective-multicentric-study
#4
J Morote, Á J Tabernero, J L Álvarez-Ossorio, J P Ciria, J L Domínguez-Escrig, F Vázquez, J Angulo, F J López, R de La Iglesia, J Romero
OBJECTIVE: To assess the effect of androgen deprivation therapy (ADT) on cognitive performance (CP) in patients with prostate cancer (PCa) after 6 months of treatment with luteinizing hormone-releasing hormone (LHRH) analogues. MATERIAL AND METHODS: Prospective, observational, multicentre, open-label study of patients diagnosed with nonmetastatic or asymptomatic metastatic PCa scheduled to receive LHRH analogues for≥6 months. We assessed four CP domains at baseline and after 6 months of ADT: 1) Working memory: Wechsler Adult Intelligence Scale III (WAIS III) Digit Span Subtest (WAIS III-Digit); 2) Visual memory: ad hoc visual memory test; 3) Visuospatial ability: Judgement of Line Orientation (JLO) and Mental Rotation of Three-Dimensional Objects (3D-Rotation); and 4) Nonverbal analytical reasoning: WAIS III Matrix Reasoning Test (WAIS III-MRT)...
October 25, 2017: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/29066090/genetic-variants-associated-with-susceptibility-to-idiopathic-pulmonary-fibrosis-in-people-of-european-ancestry-a-genome-wide-association-study
#5
Richard J Allen, Joanne Porte, Rebecca Braybrooke, Carlos Flores, Tasha E Fingerlin, Justin M Oldham, Beatriz Guillen-Guio, Shwu-Fan Ma, Tsukasa Okamoto, Alison E John, Ma'en Obeidat, Ivana V Yang, Amanda Henry, Richard B Hubbard, Vidya Navaratnam, Gauri Saini, Norma Thompson, Helen L Booth, Simon P Hart, Mike R Hill, Nik Hirani, Toby M Maher, Robin J McAnulty, Ann B Millar, Philip L Molyneaux, Helen Parfrey, Doris M Rassl, Moira K B Whyte, William A Fahy, Richard P Marshall, Eunice Oballa, Yohan Bossé, David C Nickle, Don D Sin, Wim Timens, Nick Shrine, Ian Sayers, Ian P Hall, Imre Noth, David A Schwartz, Martin D Tobin, Louise V Wain, R Gisli Jenkins
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a chronic progressive lung disease with high mortality, uncertain cause, and few treatment options. Studies have identified a significant genetic risk associated with the development of IPF; however, mechanisms by which genetic risk factors promote IPF remain unclear. We aimed to identify genetic variants associated with IPF susceptibility and provide mechanistic insight using gene and protein expression analyses. METHODS: We used a two-stage approach: a genome-wide association study in patients with IPF of European ancestry recruited from nine different centres in the UK and controls selected from UK Biobank (stage 1) matched for age, sex, and smoking status; and a follow-up of associated genetic variants in independent datasets of patients with IPF and controls from two independent US samples from the Chicago consortium and the Colorado consortium (stage 2)...
November 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29027492/global-health-promotion-y-la-investigaci%C3%A3-n-sobre-las-intervenciones-de-salud-de-la-poblaci%C3%A3-n
#6
Suzanne F Jackson
No abstract text is available yet for this article.
September 2017: Global Health Promotion
https://www.readbyqxmd.com/read/28902934/assessment-and-management-of-pain-in-newborns-hospitalized-in-a-neonatal-intensive-care-unit-a-cross-sectional-study
#7
Natália Pinheiro Braga Sposito, Lisabelle Mariano Rossato, Mariana Bueno, Amélia Fumiko Kimura, Taine Costa, Danila Maria Batista Guedes
Objective: to determine the frequency of pain, to verify the measures adopted for pain relief during the first seven days of hospitalization in the Neonatal Intensive Care Unit and to identify the type and frequency of invasive procedures to which newborns are submitted. Method: cross-sectional retrospective study. Out of the 188 hospitalizations occurred during the 12-month period, 171 were included in the study. The data were collected from the charts and the presence of pain was analyzed based on the Neonatal Infant Pain Scale and on nursing notes suggestions of pain...
September 12, 2017: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/28902933/prototype-of-a-computerized-scale-for-the-active-search-for-potential-organ-donors
#8
Érika Fernanda Dos Santos Bezerra Ludwig, Marta Cristiane Alves Pereira, Yolanda Dora Évora Martinez, Karina Dal Sasso Mendes, Mariana Angela Rossaneis
Objective: to develop a prototype of a computerized scale for the active search for potential organ and tissue donors. Method: methodological study, with the analysis of 377 electronic medical records of patients who died due to encephalic death or cardiorespiratory arrest in the intensive care units of a tertiary hospital. Among the deaths due to cardiorespiratory arrest, the study aimed to identify factors indicating underreported encephalic death cases. The Acute Physiology and Chronic Health Evaluation II and Sepsis Related Organ Failure Assessment severity indexes were applied in the protocols...
September 12, 2017: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/28886092/prediction-of-long-term-outcomes-of-hiv-infected-patients-developing-non-aids-events-using-a-multistate-approach
#9
MULTICENTER STUDY
Mar Masiá, Sergio Padilla, Santiago Moreno, Xavier Barber, Jose A Iribarren, Jorge Del Romero, Juan L Gómez-Sirvent, María Rivero, Francesc Vidal, Antonio A Campins, Félix Gutiérrez
OBJETIVES: Outcomes of people living with HIV (PLWH) developing non-AIDS events (NAEs) remain poorly defined. We aimed to classify NAEs according to severity, and to describe clinical outcomes and prognostic factors after NAE occurrence using data from CoRIS, a large Spanish HIV cohort from 2004 to 2013. DESIGN: Prospective multicenter cohort study. METHODS: Using a multistate approach we estimated 3 transition probabilities: from alive and NAE-free to alive and NAE-experienced ("NAE development"); from alive and NAE-experienced to death ("Death after NAE"); and from alive and NAE-free to death ("Death without NAE")...
2017: PloS One
https://www.readbyqxmd.com/read/28859602/corrigendum
#10
(no author information available yet)
Sayler KA, Bigelow T, Koster LG, Swenson S, Bounds C, Hernández F, Wisely SM. Development of a rapid, simple, and specific real-time PCR assay for detection of pseudorabies viral DNA in domestic swine herds. J Vet Diagn Invest 2017;29:522-528. (Original doi:10.1177/1040638717706593). In the article titled "Development of a rapid, simple, and specific real-time PCR assay for detection of pseudorabies viral DNA in domestic swine herds" by Katherine A. Sayler et al., the Acknowledgements section, should read as follows: We thank all of the researchers who provided isolates or DNA samples of PRV, including C Romero at the University of Florida, College of Veterinary Medicine (U...
September 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28855827/expression-analysis-and-biochemical-characterization-of-beans-plants-biofortificated-with-zinc
#11
Sandra Pérez Álvarez, Juan Pedro Sida-Arrerola, Esteban Sánchez Chávez, Eduardo Fidel Héctor Ardisana
The present work was carried out in greenhouse conditions at the Centro de Investigación en Alimentación y Desarrollo AC in Delicias, Chihuahua, México. Four different concentrations (0, 25, 50 and 100 μM L(-1)) of Zn chelate and sulfate were used to study the antioxidant system of Phaseolus vulgaris L. Three genes related with antioxidant activity [superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT)] were selected for expression study. Results showed that when Zn chelate at 50 and 100 μM L(-1) were applied SOD was repressed and GSH-Px expression was low at 0, 25 and 100 μM L(-1) while with sulfate form SOD expression was low and GSH-Px expression was strong in all treatment...
September 2017: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/28851779/protocol-for-a-randomised-double-masked-sham-controlled-phase-4-study-on-the-efficacy-safety-and-tolerability-of-intravitreal-aflibercept-monotherapy-compared-with-aflibercept-with-adjunctive-photodynamic-therapy-in-polypoidal-choroidal-vasculopathy-the-atlantic
#12
João Pedro Marques, Cláudia Farinha, Miguel Ângelo Costa, Ângela Ferrão, Sandrina Nunes, Rufino Silva
PURPOSE: The purpose of this study is to compare the efficacy and safety of intravitreal aflibercept (IVA) with sham photodynamic therapy (sPDT) versus IVA with verteporfin PDT (vPDT) in a Caucasian population with treatment-naive polypoidal choroidal vasculopathy (PCV), enrolling into a treat and extend (T&E) regimen. METHODS AND ANALYSIS: Randomised, double-masked, sham-controlled, multicentre phase 4 investigator-driven clinical trial. The primary outcomes are (1) change in best-corrected visual acuity (BCVA) from baseline and (2) polyp regression at week 52, assessed by indocyanine green angiography (ICGA)...
August 28, 2017: BMJ Open
https://www.readbyqxmd.com/read/28810692/resveratrol-protects-from-lipopolysaccharide-induced-inflammation-in-the-uterus-and-prevents-experimental-preterm-birth
#13
María Victoria Bariani, Fernando Correa, Emma Leishman, Ana Paula Domínguez Rubio, Andreína Arias, Aníbal Stern, Heather B Bradshaw, Ana María Franchi
STUDY QUESTION: Is resveratrol able to prevent the lipopolysaccharide (LPS)-induced preterm labor in 15-day pregnant BALB/c mice? SUMMARY ANSWER: Resveratrol prevented the LPS-induced onset of preterm labor in 64% of the cases and showed anti-inflammatory and tocolytic effects by downregulating COX-2 and iNOS expression and NOS activity, and by changing the uterine prostaglandin and endocannabinoid profiling. WHAT IS KNOWN ALREADY: Genital tract infections by Gram-negative bacteria are a common complication in human pregnancy and have been shown to increase risk of preterm delivery...
August 1, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28793128/elaboration-and-validation-of-the-medication-prescription-safety-checklist
#14
Aline de Oliveira Meireles Pires, Maria Beatriz Guimarães Ferreira, Kleiton Gonçalves do Nascimento, Márcia Marques Dos Santos Felix, Patrícia da Silva Pires, Maria Helena Barbosa
Objective: to elaborate and validate a checklist to identify compliance with the recommendations for the structure of medication prescriptions, based on the Protocol of the Ministry of Health and the Brazilian Health Surveillance Agency. Method: methodological research, conducted through the validation and reliability analysis process, using a sample of 27 electronic prescriptions. Results: the analyses confirmed the content validity and reliability of the tool...
August 3, 2017: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/28751083/proposed-action-for-the-detection-and-care-of-victims-of-hate-violence-for-health-professionals
#15
Christian Carlo Gil-Borrelli, M Dolores Martín-Ríos, M Ángeles Rodríguez-Arenas
No abstract text is available yet for this article.
July 24, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/28750875/chronic-kidney-disease-in-hypertensive-subjects-%C3%A2-60-years-treated-in-primary-care
#16
Betlem Salvador-González, Jordi Mestre-Ferrer, Maria Soler-Vila, Luisa Pascual-Benito, Eva Alonso-Bes, Oriol Cunillera-Puértolas
BACKGROUND: Hypertension (HT) is the second leading cause of kidney failure. In hypertensive patients with chronic kidney disease (CKD), blood pressure (BP) control is the most important intervention to minimise progression. For CKD diagnosis, standardised creatinine and estimated glomerular filtration rate (eGFR) testing by CKD-EPI is recommended. OBJECTIVES: To describe the prevalence and factors associated with a moderate decrease in eGFR (by CKD-EPI) and BP control in subjects with HT...
July 2017: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/28749123/-infectious-complications-related-to-external-ventricular-shunt-incidence-and-risk-factors
#17
L López-Amor, L Viña, L Martín, C Calleja, R Rodríguez-García, I Astola, L Forcelledo, L Álvarez-García, C Díaz-Gómez, J Fernández-Domínguez, F Vázquez, D Escudero
OBJECTIVE: Infectious complications related to external ventricular shunt (ICREVS) are a main problem in neurocritical intensive care units (ICU). The aim of the review is to assess the incidence of ICREVS and to analyse factors involved. METHODS: Retrospective analysis, adult polyvalent ICU in a third level reference hospital. Patients carrying external ventricular shunt (DVE) were included. Those patients with central nervous system infection diagnosed prior DVE placement were excluded...
July 25, 2017: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
https://www.readbyqxmd.com/read/28736061/short-term-reconsultation-hospitalisation-and-death-rates-after-discharge-from-the-emergency-department-in-patients-with-acute-heart-failure-and-analysis-of-the-associated-factors-the-altur-ica-study
#18
Òscar Miró, Víctor Gil, Francisco Javier Martín-Sánchez, Pablo Herrero, Javier Jacob, Carolina Sánchez, Carolina Xipell, Sira Aguiló, Pere Llorens
BACKGROUND AND OBJECTIVES: The aim of this study was to define the following in patients with acute heart failure (AHF) discharged directly from accident and emergency (A&E): rates of reconsultation to A&E and hospitalisation for AHF, and all-cause death at 30 days, rate of combined event at 7 days and the factors associated with these rates. PATIENTS AND METHOD: The study included patients consecutively diagnosed with AHF during 2 months in 27 Spanish A&E departments who were discharged from A&E without hospitalisation...
July 20, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/28724066/strategies-for-selecting-crosses-using-genomic-prediction-in-two-wheat-breeding-programs
#19
Bettina Lado, Sarah Battenfield, Carlos Guzmán, Martín Quincke, Ravi P Singh, Susanne Dreisigacker, R Javier Peña, Allan Fritz, Paula Silva, Jesse Poland, Lucía Gutiérrez
The single most important decision in plant breeding programs is the selection of appropriate crosses. The ideal cross would provide superior predicted progeny performance and enough diversity to maintain genetic gain. The aim of this study was to compare the best crosses predicted using combinations of mid-parent value and variance prediction accounting for linkage disequilibrium (V) or assuming linkage equilibrium (V). After predicting the mean and the variance of each cross, we selected crosses based on mid-parent value, the top 10% of the progeny, and weighted mean and variance within progenies for grain yield, grain protein content, mixing time, and loaf volume in two applied wheat ( L...
July 2017: Plant Genome
https://www.readbyqxmd.com/read/28724006/development-cooperation-in-water-and-sanitation-is-it-based-on-the-human-rights-framework
#20
Colin Brown, Léo Heller
The water and sanitation sector is verifiably receiving increased attention and funding through international development cooperation. Not least because of the way that it affects incentives and institutions in partner countries, development cooperation can have either positive or negative effects on human rights though. The consolidated frameworks for the human rights to water and sanitation is becoming linked to the international community's coordinated development efforts, as evidenced notably in the 2030 Agenda for Sustainable Development...
July 2017: Ciência & Saúde Coletiva
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