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Angiosarcoma

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https://www.readbyqxmd.com/read/29230880/angiosarcoma-of-the-right-atrium-and-right-ventricle
#1
Jinaga Nageswar Rao, Deepak Gowda G, Rajan Anand, Neelam B Desai
No abstract text is available yet for this article.
December 12, 2017: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/29227858/bilateral-ovarian-angiosarcoma-arising-from-the-mature-cystic-teratomas-a-case-report-and-review-of-the-literature
#2
Erik Kudela, Marcela Nachajova, Kamil Biringer, Pavol Slavik, Lukas Plank, Jan Danko
INTRODUCTION: Ovarian teratomas undergo the malignant transformation in 0.2-2% of cases. The behavior of malignancies in mature cystic teratomas (MCT) is determined by their phenotype and not their derivation from germ cells. We can recognize pure angiosarcomas or as a part of other tumors like malignant mixed Mullerian tumors and adenosarcomas. PRESENTATION OF CASE: We present the first case of bilateral ovarian angiosarcoma arising from the mature teratomas. Due to widespread disease, we performed limited surgical procedure consisting of bilateral adnexectomy and omentectomy...
December 7, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29226905/case-image-rare-cause-of-recurrent-pericardial-tamponade-cardiac-angiosarcoma
#3
Yusuf Ziya Şener, Metin Okşul, Ahmet Kıvrak, Uğur Canpolat, Serdar Aksöyek
No abstract text is available yet for this article.
December 2017: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/29220293/pathologic-angiogenesis-of-malignant-vascular-sarcomas-implications-for-treatment
#4
Jalal A Khan, Robert G Maki, Vinod Ravi
Angiosarcoma, epithelioid hemangioendothelioma, and Kaposi sarcoma are classified according to the line of differentiation that these neoplastic cells most closely resemble: the endothelial cell. Although these malignant vascular sarcomas demonstrate immunohistochemical and ultrastructural features typical of this lineage, they vary dramatically in presentation and behavior, reflecting oncologic mechanisms unique to each. Antineoplastic therapies offer significant benefit, but because of the rarity of these cancers, novel therapies are slow to develop, and treatment options for these cancers remain limited...
December 8, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29215413/fdg-pet-ct-guided-biopsy-in-angiosarcoma-of-bone-diagnosis-staging-and-beyond
#5
Antonella Matti, Andrea Farolfi, Tommaso Frisoni, Stefano Fanti, Cristina Nanni
Primary angiosarcoma of the bone (PAB) is a particularly rare and aggressive form of malignancy in the spectrum of vascular tumours, and it accounts for less than 1% of sarcomas. This case of PAB, diagnosed thanks to FDG-PET/CT guided biopsy, is a paradigm of how powerful are clinical informations that can be derived by a F-FDG PET/CT, in view of negative or inconclusive imaging of conventional radiology, starting from the metabolic characterization of an equivocal finding, the possibility to drive the biopsy towards the most active site, the accurate total body staging, the stratification of prognosis and early therapy assessment...
December 5, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29212287/the-benefit-of-everolimus-in-recurrent-epithelioid-angiosarcoma-patients-case-reports-and-literature-review
#6
Shi-Long Zhang, Li Liang, Yuan Ji, Zhi-Ming Wang, Yu-Hong Zhou
Epithelioid angiosarcoma (EA) is a kind of rare malignant soft tissue sarcoma, with high recurrence/metastatic rate and poor prognosis. To date, no effective standardized treatment regimen has been available for patients with recurrence/metastatic EA. Everolimus is an oral rapamycin derivative that highly inhibits the mechanistic target of rapamycin(mTOR) signal pathway. Previous studies have suggested that everolimus is effective and safe in some soft tissue sarcoma. We reported two cases with recurrence/metastatic EA, who received everolimus after failure of surgery, radiotherapy, chemotherapy or interventional therapy...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29208319/defining-the-incidence-and-clinical-significance-of-lymph-node-metastasis-in-soft-tissue-sarcoma
#7
Emily Z Keung, Yi-Ju Chiang, Rachel K Voss, Janice N Cormier, Keila E Torres, Kelly K Hunt, Barry W Feig, Christina L Roland
INTRODUCTION: The incidence and clinical significance of lymph node metastasis (LNM, N1) in soft tissue sarcoma (STS) is unclear. Recent studies have focused on extremity/trunk STS (ETSTS). We sought to define the subgroup of patients with LNM at sarcoma diagnosis across all disease sites and histologies. METHODS: We identified and categorized 89,870 STS patients from the National Cancer Data Base (1998-2012) by nodal stage. Pathologically confirmed LNM (pN1) were identified in 1404 patients; 1750 had clinically suspicious but not pathologically confirmed LNM (cN1)...
November 27, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29206716/primary-epithelioid-angiosarcoma-of-finger-masquerading-as-epithelioid-hemangioma-report-of-a-case-and-analysis-of-mutational-pattern-in-epithelioid-hemangiomas-and-angiosarcomas-by-next-generation-sequencing
#8
Manish M Subramaniam, Nur L Salleh, Bingcheng Wu, Michelle A Rozario, HueyJin Lim, Mark E Puhaindran, Richie Soong, Victor K Lee
AIMS: We report an unusual case of epithelioid angiosarcoma (AS) mimicking an epithelioid hemangioma (EH) and analyze mutational patterns in EHs and ASs. METHODS AND RESULTS: A 58-year-old woman presented with a finger lump and metastatic lung nodules. Initial needle biopsies showed an EH, with only focal atypical histologic features. The patient underwent finger amputation and resection of lung nodules. The amputation specimen and lung nodules revealed features of AS...
January 2018: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/29205355/clinical-outcomes-in-breast-angiosarcoma-patients-a-rare-tumor-with-unique-challenges
#9
Mai-Kim Gervais, Sally M Burtenshaw, Jessica Maxwell, Brendan C Dickson, Charles N Catton, Martin Blackstein, David McCready, Jaime Escallon, Rebecca A Gladdy
BACKGROUND: Breast angiosarcoma (AS) accounts for less than 1% of all breast cancers. The goal of this study was to determine patient outcomes in radiation-associated angiosarcoma of the breast (RAAS) and sporadic AS. We evaluated patterns of recurrence and predictors of breast AS survival. METHODS: Patients with pathologically confirmed AS from 1994 to 2014 referred to Mount Sinai Hospital/Princess Margaret Cancer Centre were included. Primary outcome was overall survival (OS)...
December 4, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29204399/cutaneous-angiosarcoma-of-scalp
#10
Sawan Kumar, Minakshi Bhardwaj, Arvind Ahuja, Ram K Gautam
No abstract text is available yet for this article.
November 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/29202196/effects-of-dlc1-deficiency-on-endothelial-cell-contact-growth-inhibition-and-angiosarcoma-progression
#11
David Sánchez-Martín, Atsushi Otsuka, Kenji Kabashima, Taekyu Ha, Dunrui Wang, Xiaolan Qian, Douglas R Lowy, Giovanna Tosato
Background: Deleted in Liver Cancer 1 (DLC1) is a tumor suppressor gene frequently deleted in cancer. However, DLC1 is not known to be deleted in angiosarcoma, an aggressive malignancy of endothelial cell derivation. Additionally, the physiologic functions of DLC1 protein in endothelial cells are poorly defined. Methods: We investigated the effects of shRNA-induced DLC1 depletion in endothelial cells. Cell growth was measured by 3H thymidine incorporation, IncuCyte imaging, and population doublings; cell death by cell cycle analysis; gene expression by Affimetrix arrays and quantitative polymerase chain reaction; NF-κB activity by reporter assays; and protein levels by immunoblotting and immunofluorescence staining...
November 30, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29200779/primary-angiosarcoma-of-the-skin-presenting-as-mild-erythema
#12
Sun Young Moon, Dong Hyuk Eun, Yong Hyun Jang, Seok-Jong Lee, Do Won Kim, Weon Ju Lee
No abstract text is available yet for this article.
December 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/29200692/a-novel-presentation-of-cutaneous-angiosarcoma-a-case-report-and-review
#13
Sonali Bajaj, Prafulla Kumar Sharma, Imroz Singh Sachdev, Minakshi Bhardhwaj
We report a case of a 70-year-old male, with slowly widening induration, ulceration, and oozing for 3 months on the scalp and face. The diagnosis of aggressive cutaneous angiosarcoma was made on histopathology and immunochemistry from the biopsy material from the involved area of the skin.
July 2017: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/29198544/hepatic-vascular-tumors-in-the-neonate-angiosarcoma
#14
Courtney Kiser McLean, Judy H Squires, Miguel Reyes-Múgica, Andrew McCormick, Burhan Mahmood
No abstract text is available yet for this article.
November 30, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29194075/cutaneous-angiosarcoma-update-on-biology-and-latest-treatment
#15
Yoshihiro Ishida, Atsushi Otsuka, Kenji Kabashima
PURPOSE OF REVIEW: The present review aims to provide readers with the latest updates on the biology and clinical management of cutaneous angiosarcoma (cAS). RECENT FINDINGS: The genomic alteration of cAS is heterogeneous. Mutations are enriched in the mitosis-activated kinase (MAPK) pathway. Functional analysis has identified molecules that may serve as potential markers and therapeutic targets of angiosarcoma. These molecules include survivin, HSP90, FOXM1, miR-497-5p, KCa3...
November 30, 2017: Current Opinion in Oncology
https://www.readbyqxmd.com/read/29190660/actionable-mutations-in-canine-hemangiosarcoma
#16
Guannan Wang, Ming Wu, Martha A Maloneyhuss, John Wojcik, Amy C Durham, Nicola J Mason, David B Roth
BACKGROUND: Angiosarcomas (AS) are rare in humans, but they are a deadly subtype of soft tissue sarcoma. Discovery sequencing in AS, especially the visceral form, is hampered by the rarity of cases. Most diagnostic material exists as archival formalin fixed, paraffin embedded tissue which serves as a poor source of high quality DNA for genome-wide sequencing. We approached this problem through comparative genomics. We hypothesized that exome sequencing a histologically similar tumor, hemangiosarcoma (HSA), that occurs in approximately 50,000 dogs per year, may lead to the identification of potential oncogenic drivers and druggable targets that could also occur in angiosarcoma...
2017: PloS One
https://www.readbyqxmd.com/read/29183343/primary-and-metastatic-cardiac-tumors-echocardiographic-diagnosis-treatment-and-prognosis-in-a-15-years-single-center-study
#17
Natsumi Nomoto, Tomoko Tani, Toshiko Konda, Kitae Kim, Takeshi Kitai, Mitsuhiko Ota, Shuichiro Kaji, Yukihiro Imai, Yukikatsu Okada, Yutaka Furukawa
BACKGROUND: The frequency of primary cardiac tumors is rare at about 0.3% by autopsy. Our objective was to investigate the characteristics and locations of cardiac tumors and to provide a prognostic analysis in our hospital. METHODS: We collected data on 95 patients with echocardiographic diagnosis or detection of cardiac tumors in a prospective analysis from 1999 to 2014. The median follow-up period was 43 months (0.5-183 months). RESULTS: The subjects included 56 men and 39 women with a mean age of 65 years...
November 28, 2017: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29181180/comprehensive-treatment-of-unresectable-cardiac-angiosarcoma-a-case-report-and-review-of-literature
#18
Chao Wang, Min Shi, Chen Yang, Tao Ma, Jinling Jiang, Ying Liu, Wenqi Xi, Zhenggang Zhu, Jun Zhang
Cardiac angiosarcoma is a rare but lethal tumor that is difficult to diagnose and treat, due to its rapid local relapse and high incidence of systemic metastasis. The prognosis of cardiac angiosarcoma is dismal, with a mean life expectancy of only a few months. We herein report a case of unresectable angiosarcoma arising from the right atrium. The patient received first-line chemotherapy with weekly paclitaxel, and second-line therapy with vinorelbine and bevacizumab upon disease progression. The progression-free survival was 6 months and the overall survival was 7 months...
November 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29176397/a-case-of-heavily-pretreated-metastatic-cardiac-angiosarcoma-treated-successfully-using-eribulin
#19
Chiaki Inagaki, Tatsunori Shimoi, Hitomi Okuma, Akiko Kitano, Akihiko Shimomura, Emi Noguchi, Makoto Kodaira, Mayu Yunokawa, Kan Yonemori, Chikako Shimizu, Akihiko Yoshida, Yasuhiro Fujiwara, Kenji Tamura
Eribulin mesylate (eribulin) is a nontaxane microtubule inhibitor approved in Japan for treating soft tissue sarcoma irrespective of histological subtypes. Thus, our department routinely uses eribulin to treat any histological subtype of sarcoma for patients who have experienced disease progression during standard therapy. However, evidence on the efficacy of eribulin in treating sarcomas that are neither liposarcoma nor leiomyosarcoma is limited. Recently, we encountered a case of a heavily pretreated cardiac angiosarcoma that responded well to eribulin treatment...
November 23, 2017: Anti-cancer Drugs
https://www.readbyqxmd.com/read/29176321/clinical-characteristics-and-prognostic-factors-of-small-intestine-angiosarcoma-a-retrospective-clinical-analysis-of-66-cases
#20
Rong Li, Ze-Ying Ouyang, Jun-Bo Xiao, Jian He, Yan-Wu Zhou, Gui-Ying Zhang, Qian Li, Huan Gu, Ai-Min Leng, Ting Liu
BACKGROUND/AIMS: Primary angiosarcoma of the small intestine is a rare neoplasia, and there are limited data from systematic analyses. The aim of this study is to describe the clinical and pathological characteristics in addition to the prognostic factors for this rare neoplasia. METHODS: We retrospectively collected the clinical records and prognostic information of 66 patients with small intestine angiosarcoma reported between 1970 and 2017. We used the Chi-square test, the log-rank test, and Cox regression analyses to evaluate the data...
November 24, 2017: Cellular Physiology and Biochemistry
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