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Angiosarcoma

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https://www.readbyqxmd.com/read/28721475/epithelioid-hemangioma-of-bone-radiologic-and-magnetic-resonance-imaging-characteristics-with-histopathological-correlation
#1
Kathleen Schenker, Steven Blumer, Diego Jaramillo, Amanda L Treece, Aashim Bhatia
BACKGROUND: Epithelioid hemangioma is a rare vascular tumor that can occur in soft tissues or bone. The tumor is part of a spectrum of vascular tumors that also includes epithelioid hemangioendothelioma and angiosarcoma. When involving the bone, the tumor usually involves the metaphysis or diaphysis of the long tubular bones and most commonly occurs in adults. It has been rarely reported in pediatric patients, and in these reported patients, the tumor primarily involves the epiphysis...
July 18, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28716069/angiosarcoma-treated-successfully-with-anti-pd-1-therapy-a-case-report
#2
Simran Sindhu, Lana H Gimber, Lee Cranmer, Ali McBride, Andrew S Kraft
BACKGROUND: Angiosarcomas are tumors of malignant endothelial origin that have a poor prognosis with a five-year survival of less than 40%. These tumors can be found in all age groups, but are more common in older patients; with the cutaneous form most common in older white men. Combined modality therapy including surgery and radiation appears to have a better outcome than each modality alone. When metastatic, agents such as liposomal doxorubicin, paclitaxel and ifosfamide have activity but it is short-lived and not curative...
July 18, 2017: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/28710797/surgical-treatment-associated-with-improved-survival-in-patients-with-cutaneous-angiosarcoma
#3
O Trofymenko, C Curiel-Lewandrowski
Cutaneous angiosarcoma is a rare aggressive vasoformative neoplasm of the skin with a poor prognosis.(1) The neoplasm preferentially involves areas of head and neck and usually diagnosed in advanced stage.(1, 2) The neoplasm accounts for only 2% of soft-tissue sarcomas in the U.S. and most often affects elderly white males, patients treated with radiation, and individuals with certain chronic lymphatic disorders.(3) Surgery with or without adjuvant or neoadjuvant radiation therapy (RT) is considered the mainstay of therapy...
July 14, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28709411/rho-kinase-proteins-display-aberrant-upregulation-in-vascular-tumors-and-contribute-to-vascular-tumor-growth
#4
Clarissa N Amaya, Dianne C Mitchell, Brad A Bryan
BACKGROUND: The serine/threonine protein kinases ROCK1 and 2 are key RhoA-mediated regulators of cell shape and cytoskeletal dynamics. These proteins perform multiple functions in vascular endothelial cell physiology and are attractive targets for cancer therapy based on their roles as oncogenes and metastatic promoters. Given their critical functions in both of these processes, we hypothesized that molecular targeting of ROCK proteins would be exceedingly effective against vascular tumors such as hemangiomas and angiosarcomas, which are neoplasms composed of aberrant endothelial cells...
July 14, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28705018/secondary-pneumothorax-induced-by-metastatic-angiosarcoma
#5
Yasuhito Sakano, Shun-Suke Endo, Yoshio Misawa
No abstract text is available yet for this article.
January 1, 2017: Asian Cardiovascular & Thoracic Annals
https://www.readbyqxmd.com/read/28704748/clinicopathological-features-of-breast-angiosarcoma-a-16-years-single-institution-experience
#6
Badria Aljohani, Taher Al-Twajeri, Ahmed Alameer, Turki Alzaydi, Saad Alawwad, Ihab Anwar, Mohmmed Alshabanh, Asma Tulba, Osama Almalik
BACKGROUND: Breast Angiosarcoma is a rare type of malignancy arising from endothelial cells lining blood vessels, accounting for 1% of all soft tissue breast tumors. This retrospective study describes the clinical pathological features and clinical management and outcomes of a series of 5 patients with primary and secondary Angiosarcoma of the breast present to King Faisal Specialty Hospital and Research Center during the last 16 years. METHODS: A retrospective review of our institution's pathology database was conducted and all patients who had a pathologically confirmed breast angiosarcoma were included in this study...
June 30, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28702406/epithelioid-angiosarcoma-10-years-postrenal-transplant
#7
Nitin Gupta, Natasha Singh, Ameya D Puranik, Akshay Bedmutha
No abstract text is available yet for this article.
April 2017: South Asian Journal of Cancer
https://www.readbyqxmd.com/read/28699109/malignant-mesenchymal-neoplasms-of-the-dermis-and-subcutis-mimicking-benign-lesions-a-case-based-review
#8
Thomas Mentzel, Thomas Brenn
In this short review, malignant mesenchymal neoplasms of the dermis and subcutis mimicking benign lesions and their differential diagnoses are discussed. These include plaque-like dermatofibrosarcoma protuberans, superficial low-grade fibromyxoid sarcoma, low-grade superficial malignant peripheral nerve sheath tumour, epithelioid sarcoma, pseudomyogenic haemangioendothelioma, Kaposi sarcoma mimicking cavernous haemangioma and benign lymphangioendothelioma, and rare forms of angiosarcoma mimicking a benign vascular lesion...
July 12, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28693598/clinical-manifestations-and-diagnostic-methods-in-pulmonary-angiosarcoma-protocol-for-a-scoping-review
#9
Rachel Lim, Lea Harper, John Swiston
BACKGROUND: Angiosarcoma involving the lung can represent either primary or metastatic malignancy. Due to the rarity of this condition, knowledge surrounding the natural history and clinical presentation is scarce. The aim of this scoping review is to summarize the existing literature on pulmonary angiosarcoma, particularly as it pertains to the clinical presentation and ancillary tests used for diagnosis in addition to histopathology. METHODS: We will conduct a systematic search using Ovid MEDLINE and EMBASE electronic databases...
July 10, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28693219/f-18-fluorodeoxyglucose-positron-emission-tomography-for-differential-diagnosis-and-prognosis-prediction-of-vascular-tumors
#10
Won Woo Lee, Young So, Seo Young Kang, Min-Kyung So, Haeryoung Kim, Hyun Woo Chung, Wan Seop Kim, Sang Eun Kim
The spectrum of vascular tumors ranges from hemangioma (HEM), to epithelioid hemangioendothelioma (EHE) and to angiosarcoma (AS). To the best of our knowledge, the usefulness of F-18 fluorodeoxyglucose positron emission tomography (FDG-PET) for vascular tumors has never been comprehensively studied. The present study investigated the usefulness of FDG-PET for pathologically diagnosed vascular tumors. The present study included 26 patients with vascular tumor (male:female, 17:9; age, 60.9±14.4 years; 7 HEM, 6 EHE and 13 AS) who underwent FDG-PET between January 2007 and May 2014 at the Seoul National University Bundang Hospital (Seongnam, Korea) and Konkuk University Medical Center, (Seoul, Korea)...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28691862/simplifying-breast-imaging-reporting-and-data-system-classification-of-mammograms-with-pure-suspicious-calcifications
#11
Gisela Lg Menezes, Gonneke Ao Winter-Warnars, Eva L Koekenbier, Emma J Groen, Helena M Verkooijen, Ruud M Pijnappel
Objectives To investigate the risk of malignancy following stereotactic breast biopsy of calcifications classified as Breast Imaging Reporting and Data System (BI-RADS) 3, 4, and 5. Methods The study included women with pure calcifications (not associated with masses or architectural distortions) who underwent stereotactic breast biopsy at the Dutch Cancer Institute between January 2011 and October 2013. Suspicious calcifications (Breast Imaging Reporting and Data System 3, 4, or 5) detected on mammography were biopsied...
January 1, 2017: Journal of Medical Screening
https://www.readbyqxmd.com/read/28691211/comprehensive-profiling-of-h-ras-signalling-in-angiosarcoma-endothelium
#12
A da Costa, M Bonner, J L Arbiser
The MS1/SVR system, in which MS1 represents immortalized endothelial cells and SVR represents MS1 cells transformed with oncogenic human-rat sarcoma protein (H-Ras), has been used for around 20 years as a valuable tool to study angiogenesis and carcinogenesis. Despite the use of these cells in numerous studies, a comprehensive profile of the signalling differences due to oncogenic H-Ras transformation has not been performed previously. In this study, we profiled the well-known MS1 and SVR cell lines using a combination of both Western blot and gene chip assays...
July 10, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28682861/right-femoral-pathological-fracture-caused-by-primary-bone-epithelioid-angiosarcoma-case-report
#13
Yatong Li, Xiongfei Zou, Xiaoyan Chang, Xiao Chang, Shengfang Sun, Baozhong Zhang
RATIONALE: Epithelioid angiosarcoma (EAS) is an extremely rare malignant disease, which accounts no more than 1% of all soft tissue sarcomas. In this article, we would report a new case of EAS with multiple bone destruction and right femoral pathological fracture, which was an even rarer manifestation of EAS. PATIENT CONCERNS: In this case, a 64-year-old man with right femoral fracture was reported. He had suffered from a progressive low back pain for about 8 months, and the imaging examinations prompted a multiple bone destruction in his vertebra and lower limbs...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28680781/primary-hepatic-angiosarcoma-mimicking-multifocal-liver-abscess-with-disseminated-intravascular-coagulation-and-hemoperitoneum
#14
Kyle Rowe, Fredy Nehme, Jacob Wallace, Travis McKenzie, Akash Joshi, William Salyers
Primary hepatic angiosarcoma (PHA), a rare and aggressive malignancy, has rarely been reported to present with disseminated intravascular coagulation with liver hemorrhage. Incidence is estimated at 0.5-2.5 cases per 10,000,000. To our knowledge, it has not been reported to mimic liver abscess with a septic presentation. Advanced imaging techniques may aid in the diagnosis, though biopsy with microscopy and immunohistochemistry is the mainstay. Prognosis is very poor, with a 5-year survival rate estimated at 6...
May 30, 2017: Curēus
https://www.readbyqxmd.com/read/28680558/primary-pulmonary-artery-sarcoma-masquerading-as-pulmonary-thromboembolism-a-rare-diagnosis-unveiled
#15
Abhishek Mahajan, Bharat Rekhi, Siddhartha Laskar, Jyoti Bajpai, Lekshmy Jayasree, Meenakshi H Thakur
BACKGROUND: Primary pulmonary artery sarcomas are rare malignant vascular tumors and carry a very poor prognosis. Due to overlapping clinical and radiological features, the differentiation between pulmonary artery thromboembolism and pulmonary artery sarcoma can be challenging. CASE PRESENTATION: We herein present clinical, radiological and pathological features of primary pulmonary artery high grade sarcoma (angiosarcoma) in a 59-year-old male. The patient presented with a history of breathlessness on exertion of 2-months duration and was misdiagnosed as massive pulmonary thromboembolism on initial CT imaging...
2017: Clinical Sarcoma Research
https://www.readbyqxmd.com/read/28680008/spontaneous-regression-of-chemotherapy-resistant-metastases-from-a-scalp-angiosarcoma
#16
Masahiro Suzuki, Takashi Matsuzuka, Masakazu Ikeda, Yuta Nakaegawa, Tetsuro Kobayashi, Tomotaka Kawase, Takehiro Kobari, Shigeyuki Murono
Angiosarcomas are rare malignant tumors derived from endothelial cells and occur most commonly in the scalp and the face. The prognosis is poor. Therefore, spontaneous regression of angiosarcoma is a rare phenomenon.We describe a case of a 73-year-old man with multiple metastatic angiosarcoma.In the present case, weekly paclitaxel therapy had an effect, but could not be continued because of interstitial pneumonia (IP). Weekly docetaxel therapy did not have an effect, but further chemotherapy was not carried out because aggravation of the IP was a concern...
July 5, 2017: Fukushima Journal of Medical Science
https://www.readbyqxmd.com/read/28676174/vascular-lesions-of-the-breast
#17
REVIEW
Gabrielle M Baker, Stuart J Schnitt
Vascular lesions of the breast comprise a heterogeneous group that includes a variety of benign, atypical, and malignant lesions. The presentation of these lesions ranges from those that are microscopic and discovered incidentally, to large tumors that may extensively involve the breast parenchyma and skin. In addition, some non-vascular breast lesions have features that may mimic those of vascular lesions and need to be distinguished from them in order to avoid an erroneous diagnosis. In this review, we discuss the spectrum of vascular lesions of the breast with particular emphasis on those lesions of greatest clinical importance, angiosarcoma and atypical vascular lesions...
May 30, 2017: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/28670594/intravascular-papillary-endothelial-hyperplasia-of-the-jejunum-as-a-cause-of-obscure-overt-gastrointestinal-bleeding
#18
Jonathan Gotfried, Raul Berio Dorta, Jennifer Maranki
Intravascular papillary endothelial hyperplasia (IPEH), or Masson's tumor, is a rare, benign vascular lesion characterized by reactive endothelial proliferation with venous stasis and thrombus. Lesions typically arise in vascular regions of the head and neck or extremities, but involvement of other organ systems has been reported. Clinically, IPEH mimics other benign lesions (hemangiomas) and malignant neoplasms (angiosarcoma) depending on the affected site. Diagnosis is essential because local excision of certain IPEH subtypes is curative...
2017: ACG Case Reports Journal
https://www.readbyqxmd.com/read/28665237/genital-angiokeratomas-of-fordyce-595-nm-variable-pulse-pulsed-dye-laser-treatment
#19
Ján Baumgartner, Mária Šimaljaková
BACKGROUND: Angiokeratoma of Fordyce (AF) are dark red or blue-black papules with scaly surface located on scrotum, labia majora and penis. Though usually asymptomatic, bleeding after mechanical trauma and sexual intercourse may occure. AF should be differentiated from malignant melanoma, angiosarcoma and other pigmented lesions. The treatment, usually asked from patients as the result of anxiety and social embarrassment should be performed in an non-aggresive manner. OBJECTIVES: To determine the safety and effectiveness of 595-nm variable-pulse pulsed dye laser (VPPDL) with Dynamic Cooling Device (DCD) in treatment of AF...
June 30, 2017: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/28664548/cardiac-magnetic-resonance-in-cardiac-angiosarcoma
#20
Jennifer Lindsey, Richard B Stacey
BACKGROUND: While echocardiography is effective for initial identification of anatomic location, magnetic resonance imaging (MRI) is a more advantageous modality for delineating tumor expanse, spread, and blood supply preoperatively. Emerging patterns may even help generate a specific diagnosis prior to biopsy and histopathology. CASE PRESENTATION: Our case of a 67-year-old male referred for cardiac magnetic resonance to further evaluate a cardiac mass highlights the sophisticated level of data which can be collected...
June 29, 2017: Echocardiography
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