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Angiosarcoma

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https://www.readbyqxmd.com/read/29674005/breast-cancer-cutaneous-metastases-mimicking-papilloma-cutis-lymphostatica-biopsy-to-avoid-pitfalls
#1
Giuseppe Giudice, Michelangelo Vestita, Fabio Robusto, Paolo Annoscia, Francesco Ciancio, Eleonora Nacchiero
INTRODUCTION: Secondary lymphedema is the most frequent long-term complication of axillary lymphadenectomy. It can result in complication as erysipelas, warts, Papilloma Cutis Lymphostatica (PCL), or angiosarcomas. Moreover, in women affected by breast cancer an accurate differential diagnosis among these conditions or complication related to radiation dermatitis or cutaneous metastasis is essential. PRESENTATION OF CASE: We report the case of a 60-year-old postmenopausal Caucasian woman affected by secondary lymphedema following complete mastectomy for breast cancer...
April 10, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29663331/three-cases-of-advanced-cutaneous-angiosarcoma-treated-with-eribulin-investigation-of-serum-soluble-cd163-and-cxcl10-as-possible-biomarkers-predicting-the-biological-behaviour-of-angiosarcoma
#2
T Fujimura, Y Sato, Y Kambayashi, K Tanita, A Tsukada, H Terui, A Hashimoto, S Aiba
Cutaneous angiosarcoma (CAS) is a highly aggressive vascular tumour that recurs locally and metastasizes early. Although chemoradiotherapy with taxanes shows a high response rate with prolonged survival, second-line therapy for advanced CAS remains contentious. This report describes three cases of advanced CAS treated with eribulin. In addition, we investigated serum sCD163, CXCL10 and CCL22 levels at several time points of tumour progression in these patients, revealing serum levels of sCD163 and CXCL10 as potential biomarkers for progression of CAS...
April 17, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29661049/academic-facility-utilization-and-survival-outcomes-in-adult-head-and-neck-sarcomas-an-ncdb-analysis
#3
Richard B Cannon, Patrick S Carpenter, Dustin Boothe, Luke O Buchmann, Jason P Hunt, Shane Lloyd, Ying J Hitchcock, Jeffrey J Houlton, John R Weis, Hailey M Shepherd, Marcus M Monroe
Objectives To investigate clinicopathologic and treatment factors associated with survival in adult head and neck sarcomas in the National Cancer Database (NCDB). To analyze whether treatment settings and therapies received influence survival outcomes and to compare trends in utilization via an aggregated national data set. Study Design Prospectively gathered data. Setting NCDB. Subjects and Methods The study comprised a total of 6944 adult patients treated for a head and neck sarcoma from January 2004 to December 2013...
April 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29660567/summary-of-expression-of-sparc-protein-in-cutaneous-vascular-neoplasms-and-mimickers
#4
Shakuntala H Mauzo, Denái R Milton, Victor G Prieto, Carlos A Torres-Cabala, Wei-Lien Wang, Nitin Chakravarti, Priyadharsini Nagarajan, Michael T Tetzlaff, Jonathan L Curry, Doina Ivan, Robert E Brown, Phyu P Aung
BACKGROUND: Serum protein acidic and rich in cysteine (SPARC) is a matricellular glycoprotein, which regulates cell proliferation and facilitates intracellular transport of albumin bound particles including chemotherapeutic agents such as Nab-paclitaxel/ABI-007. Therefore the presence of SPARC may achieve higher intra-tumoral drug concentration with lower dosage and thus reduce systemic side-effects. Several trials of ABI-007, in melanoma, show promising clinical activity. DESIGN: Fifty-four cases of dermal based neoplasms were retrieved including 24 angiosarcomas (AS), 10 hemangiomas, 9 nodular melanomas, 4 Kaposi sarcomas (KS), 3 leiomyosarcomas (LMS), 3 atypical fibroxanthomas (AFX) and 1 spindle cell squamous cell carcinoma (SSCC)...
March 15, 2018: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29643660/primary-splenic-angiosarcoma-with-liver-metastasis-a-rare-neoplasm-diagnosed-on-fine-needle-aspiration-cytology-and-cell-block-immunocytochemistry
#5
Saniya Sharma, Priya Singh, Pankaj Gupta, Anupam Lal, Radhika Srinivasan
Primary splenic angiosarcoma is a rare malignant vascular neoplasm of mesenchymal origin. The tumor is highly aggressive and has a high metastatic potential. It is usually diagnosed on histopathological examination of splenectomy specimen. Only few cases of angiosarcoma diagnosed by fine-needle aspiration (FNA) cytology alone have been reported in the literature. The cytologic features of angiosarcoma are heterogeneous, however, diagnosis can be suggested by FNA when vasoformative features are present. A 55-year-old female presented with abdominal pain and hepatosplenomegaly...
April 2018: Journal of Cytology
https://www.readbyqxmd.com/read/29623568/metachronous-hepatic-angiosarcoma-presenting-as-a-mimic-of-recurrent-hepatocellular-carcinoma
#6
Eric K C Lau, Bernette Tsai, Harry Morrison, Michael Deftos, Albert Y Lin
No abstract text is available yet for this article.
April 6, 2018: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29623256/association-between-programmed-death-ligand-1-expression-and-the-vascular-endothelial-growth-factor-pathway-in-angiosarcoma
#7
Sanjay P Bagaria, Zoran Gatalica, Todd Maney, Daniel Serie, Mansi Parasramka, Steven Attia, Murli Krishna, Richard W Joseph
Angiosarcoma is a vascular malignancy associated with a poor prognosis and chemotherapy resistance. The tumor immune microenvironment of angiosarcoma has not been characterized. We investigated the expression of programmed death-ligand 1 (PD-L1) and programmed death 1 (PD-1) in angiosarcoma and correlated these findings with vascular endothelial growth factor (VEGF)-related gene expression and survival. Using archived formalin-fixed paraffin-embedded tissues of primary and metastatic angiosarcoma specimens, we characterized the immunohistochemical (IHC) expression of PD-L1 and PD-1...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29620582/radiation-associated-angiosarcoma-mimicking-fallopian-tube-high-grade-serous-carcinoma-in-a-woman-with-de-novo-li-fraumeni-syndrome
#8
Sarah M Crafton, Leigha Senter-Jamieson, James L Chen, Larry J Copeland, Adrian A Suarez
We present a case study of a woman with history of rectal adenocarcinoma, and a new diagnosis of radiation-associated angiosarcoma mimicking fallopian tube high-grade serous carcinoma who was subsequently found to have de novo Li-Fraumeni syndrome. Our objective is to highlight angiosarcoma as a potential pitfall in the diagnosis of high-grade serous carcinoma.
April 3, 2018: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/29619993/a-case-of-cutaneous-angiosarcoma-successfully-treated-with-eribulin
#9
Kazuma Iwamoto, Yasuhiro Fujisawa, Yousuke Ishitsuka, Hiroshi Maruyama, Yoshiyuki Nakamura, Naoko Okiyama, Rei Watanabe, Manabu Fujimoto
No abstract text is available yet for this article.
April 5, 2018: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/29617509/a-rare-cause-of-abdominal-pain-in-childhood-cardiac-angiosarcoma
#10
Elvan Caglar Citak, Murat Ozeren, M Kerem Karaca, Derya Karpuz, Feryal Karahan, Eda Bengi Yilmaz, Yuksel Balci, Pelin Ozcan Kara, Rabia Bozdogan Arpaci
Cardiac angiosarcomas are extremely rare in childhood, they are rapidly progressive tumours that often present themselves as diagnostic dilemmas, resulting in delayed diagnosis. Also, extracardiac manifestations, including abdominal pain, are extremely rare in patients with intracardiac tumors. We herein present the case of a 15-year-old girl who presented with abdominal pain. Echocardiography and thoracic computed tomography showed right atrial mass. The patient underwent surgery, chemotherapy, and radiotherapy...
January 2018: Brazilian Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/29607237/adjuvant-radiochemotherapy-with-a-23-month-overall-survival-time-in-a-patient-after-a-surgery-due-to-splenic-hemangiosarcoma-rupture-a-case-report-with-the-literature-review
#11
M Bilski, D Surdyka, I Paśnik, M Bilska, P Cisek, P Korona, J Szumiło, L Grzybowska-Szatkowska
Spleen sarcoma is one of the most rare soft tissue malignancies. The annual incidence is 0.14-0.25/1,000,000 and the average age of diagnosis is 50 to 73 years. The incidence of this cancer has been increasing. Treatment of choice is surgical splenectomy, which rarely gives good results due to the aggressive course of the disease as well as the high potential for metastasis. Overall survival in primary spleen sarcomas as described by various authors is between 4 and 14 months. 80% of patients after spleen rupture do not survive 6 months...
2018: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/29594234/strong-radioprotective-fgf1-signaling-down-regulates-proliferative-and-metastatic-capabilities-of-the-angiosarcoma-cell-line-isos-1-through-the-dual-inhibition-of-egfr-and-vegfr-pathways
#12
Taichi Miura, Mayumi Fujita, Mitsuko Kawano, Kaori Imadome, Takeshi Yasuda, Shoko Nishihara, Toru Imamura, Mikio Masuzawa, Takashi Imai, Fumiaki Nakayama
Background and purpose: Angiosarcoma is associated with a poor prognosis and is treated with radiotherapy. Although FGF1 is a potential radioprotector, the influence of FGF1 on the malignancy of angiosarcoma remains unknown. Materials and methods: Highly stable FGF1 mutants, which exhibit stronger mitogenic activity than wild-type FGF1, were examined as strong radioprotectors and signaling agonists to clarify the effects of FGF1 on the murine angiosarcoma cell line ISOS-1...
December 2017: Clinical and Translational Radiation Oncology
https://www.readbyqxmd.com/read/29576414/imaging-and-pathologic-findings-of-hepatic-small-vessel-hemangioma
#13
Balasubramanya Rangaswamy, Marta Minervini, Mitchell Tublin, Biatta Sholosh, Anil K Dasyam
Hepatic small vessel hemangioma represents a distinct yet very rare pathologic entity of the liver. The entity has also been in the past referred to as adult capillary hemangioma of the liver and congenital noninvoluting hemangioma. Imaging findings are not definitive and biopsy or resection is ultimately necessary. Pathologically these represent vasoformative abnormalities with infiltrative margins that can potentially mimic hepatic angiosarcoma. Immunohistochemistry can help differentiate hepatic small vessel hemangioma from angiosarcoma...
February 14, 2018: Current Problems in Diagnostic Radiology
https://www.readbyqxmd.com/read/29570226/cutaneous-angiosarcoma-the-role-of-dermoscopy-to-reduce-the-risk-of-a-delayed-diagnosis
#14
Emanuele Cozzani, Chiara Chinazzo, Giovanni Ghigliotti, Carlotta Pastorino, Giulia Gasparini, Aurora Parodi
No abstract text is available yet for this article.
March 23, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29563744/solitary-primary-intraosseous-angiosarcoma-of-the-mandible
#15
Arvind Krishnamurthy
Angiosarcoma is a malignant vascular tumor derived from the mesenchymal cells which have undergone an angioblastic differentiation. About half of the angiosarcomas are reported to localize in the skin and soft tissues of the head and neck, i.e., found predominantly to arise from the scalp and face. Angiosarcomas rarely involve the skeletal system, wherein they generally have a tendency for multicentricity. Primary bony angiosarcoma accounts for about 6% of all the angiosarcomas and about 1.4% of all the primary bony sarcomas...
March 2018: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29555155/surgery-with-curative-intent-is-associated-with-prolonged-survival-in-patients-with-cutaneous-angiosarcoma-of-the-scalp-and-face-a-retrospective-study-of-38-untreated-cases-in-the-japanese-population
#16
Kohei Oashi, Kenjiro Namikawa, Arata Tsutsumida, Akira Takahashi, Jun Itami, Hiroshi Igaki, Koji Inaba, Naoya Yamazaki
BACKGROUND: In patients with cutaneous angiosarcoma of the scalp and face, the validity of surgery remains controversial, because of the potentially diffuse nature of involvement and difficulty in obtaining negative margins. OBJECTIVE: To evaluate the survival benefit of surgery as a primary treatment. PATIENTS AND METHODS: Fifty-one patients with primary cutaneous angiosarcoma of the scalp and face presenting with locoregional involvement were referred to National Cancer Center Hospital, Tokyo, Japan, between May 1982 and March 2013...
March 6, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29552543/cutaneous-angiosarcoma-the-possibility-of-new-treatment-options-especially-for-patients-with-large-primary-tumor
#17
REVIEW
Yasuhiro Fujisawa, Koji Yoshino, Taku Fujimura, Yoshiyuki Nakamura, Naoko Okiyama, Yosuke Ishitsuka, Rei Watanabe, Manabu Fujimoto
The most widely accepted treatment for cutaneous angiosarcoma (CAS) is wide local excision and postoperative radiation to decrease the risk of recurrence. Positive surgical margins and large tumors (T2, >5 cm) are known to be associated with poor prognosis. Moreover, T2 tumors are known to be associated with positive surgical margins. According to previous reports, the majority of CAS patients in Japan had T2 tumors, whereas less than half of the patients in the studies from western countries did so. Consequently, the reported 5-year overall survival of Japanese CAS patients without distant metastasis was only 9%, lower than that for stage-IV melanoma...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29545961/primary-peritoneal-angiosarcoma-metastatic-to-liver-and-bone-without-history-of-radiation-therapy
#18
Way Chiang, Zofia Tynski
Angiosarcoma is a rare vascular soft tissue tumor of endothelial origin most commonly seen in the elderly as a primary cutaneous head and neck malignancy. Furthermore, a peritoneal angiosarcoma is an exceedingly rare entity. This is the second case of primary peritoneal angiosarcoma reported in literature that is not associated with prior radiotherapy. Herein, we describe a case of primary peritoneal angiosarcoma metastatic to both the liver and bone in a male patient with metachronous renal cell carcinoma and parathyroid adenoma...
2018: Case Reports in Pathology
https://www.readbyqxmd.com/read/29533277/unusual-neuroendocrine-differentiation-in-a-small-round-cell-angiosarcoma-a-potential-histologic-mimicker-of-superficial-ewing-sarcoma
#19
Isidro Machado, Carlos Santonja, Victoria Huerta, Julia Cruz, Celia Requena, Luis Requena, Antonio Llombart-Bosch
Neuroendocrine differentiation or aberrant expression of neuroendocrine markers is very uncommon in angiosarcomas (AS) and creates a challenging differential diagnosis with other superficial or soft tissue tumors. Herein, we report a new case of superficial AS presenting as a tumor lesion on the little finger of the right hand of a 52-year-old man. The tumor displayed CD56, chromogranin-A, and synaptophysin immunoreactivity. Tumor cells were positive for vascular markers (CD31, FLI1, ERG, D2-40, VE-cadherin, VEGR1,2, and 3), CD99, and EMA, but were negative for S100, CK (AE1/AE3), CK20, polyomavirus, and myogenic (desmin and myogenin) and melanocyte markers (melan-A and HMB45)...
February 27, 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29532112/implant-and-limb-survival-after-resection-of-primary-bone-tumors-of-the-lower-extremities-and-reconstruction-with-mega-prostheses-fifty-patients-followed-for-a-mean-of-forteen-years
#20
Christina Enciso Holm, Christian Bardram, Anja Falk Riecke, Peter Horstmann, Michael Mørk Petersen
PURPOSE: Previous studies reported variable outcome and failure rates after mega-prosthetic reconstructions in the lower extremities. The purpose of this study was to make a long-term single-center evaluation of patients treated with limb-sparing surgery and reconstruction with mega-prostheses in the lower extremities. METHODS: We identified 50 patients (osteosarcoma (n = 30), chondrosarcoma (n = 9), osteoclastoma (n = 6), Ewing sarcoma (n = 4), angiosarcoma (n = 1)), who underwent limb-sparing reconstruction of the lower extremities (proximal femur (n = 9), distal femur (n = 29), proximal tibia (n = 9), and the entire femur (n = 3)) between 1985 and 2005...
March 12, 2018: International Orthopaedics
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