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F De Felice, E Moscatelli, S Orelli, N Bulzonetti, D Musio, V Tombolini
Thyroid angiosarcoma (TAS) is rare and represents a very aggressive malignancy. Its rarity is principally linked to two major pitfalls. Firstly, TAS histopathology diagnosis can be difficult; second, the limited clinical experience with this condition can make its management complex. We conducted a detailed systematic review, focusing on the knowledge available regarding TAS etiopathogenesis, treatment options and prognosis. The aim is to present the main TAS characteristics and to summarize the clinical experiences described worldwide, in order to provide a useful clinical tool...
July 2018: Oral Oncology
Luis Gorospe, Alberto Cabañero-Sánchez, Gemma María Muñoz-Molina, Ana María Ayala-Carbonero, María Ángeles Fernández-Méndez
No abstract text is available yet for this article.
May 2018: Arquivos Brasileiros de Cardiologia
Adela Nechifor-Boilă, Myriam Decaussin-Petrucci, Agota Varga-Ilyés, Laura Chinezu, Cosmin Caraşca, Angela Borda
We report three primary thyroid angiosarcoma (PTA) cases revealing distinctive morphological features. A systematic literature review completed our analysis to evaluate the most important morphological factors for predicting prognosis in PTAs. Three rare PTA cases were analysed. In addition, we identified 46 previously reported PTAs with available follow-up data to compare morphological features related to prognosis between patients with a favourable <i><i><i><i>versus</i></i></i></i> aggressive outcome...
2018: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
Fumika Fujii, Takefumi Kimura, Naoki Tanaka, Daisuke Kubota, Ayumi Sugiura, Takeji Umemura, Shuichi Wada, Eiji Tanaka
A 76-year-old woman was referred to our hospital due to massive gingival bleeding following teeth extraction. Laboratory findings suggested disseminated intravascular coagulopathy (DIC). Enhanced computed tomography and magnetic resonance imaging disclosed multiple hypervascular liver masses of 2-6 cm in diameter, the largest of which displaying an irregular enhancement pattern. We considered that her DIC was caused by the multiple liver masses and commenced repeated erythrocyte/fresh frozen plasma infusión and gabexate mesilate administration...
July 2018: Annals of Hepatology
Juliane Comunello, Suely Akiko Nakagawa, Felipe D'Almeida Costa, Wagner Santana Cerqueira, Wu Tu Chung, Fábio Fernando Eloi Pinto
Primary osseous angiosarcoma is a rare entity with variable biological behavior and poor prognosis. Little is known about the oncologic treatment and its etiology is still unknown. This study presents a case of lytic lesion in the right femur with dissemination to other bones, such as the vertebral column and skull, and to the lungs and central nervous system. Orthopedic surgery was performed in order to improve quality of life. Surgical specimen confirmed the diagnosis of high-grade malignant osseous angiosarcoma...
May 2018: Revista Brasileira de Ortopedia
Nivedita Sharma, Nebu Abraham George, Rajesh Singh, Elizabeth Mathew Iype, Bipin T Varghese, Shaji Thomas
Head and neck soft tissue sarcoma (HNSTS) is a rare neoplasm accounting for 1% of all head and neck tumours. Because of rarity and varied biological behaviour among various subtypes, knowledge about these tumours is limited. This study aimed at analysing clinicopathological, recurrence and survival pattern of surgically treated HNSTS. Case records of 28 patients of HNSTS who underwent surgery at the Regional Cancer Centre (RCC), Trivandrum (India) between 2002 and 2012 were analysed retrospectively for demographic profile, clinical features, treatment given, recurrence pattern and outcome...
June 2018: Indian Journal of Surgical Oncology
Kuo-Hua Lin, Hsu-Heng Yen
No abstract text is available yet for this article.
June 7, 2018: ANZ Journal of Surgery
Michele Correale, Nicola Tarantino, Riccardo Ieva, Matteo Gravina, Grazia Casavecchia, Caterina Strazzella, Matteo Di Biase, Natale Daniele Brunetti
No abstract text is available yet for this article.
January 1, 2018: Pulmonary Circulation
Michelle L Chadwick, Adam Lane, Dana Thomas, Amanda R Smith, Angela R White, Dominique Davidson, Yuxin Feng, Elisa Boscolo, Yi Zheng, Denise M Adams, Anita Gupta, André Veillette, Lionel M L Chow
Angiosarcoma is an aggressive malignancy of vascular origin that occurs de novo or in the context of previous cancer therapy. Despite multi-modal aggressive treatment including surgical resection, chemotherapy, and radiation, five-year overall survival remains poor at 35%. Due to its rarity, little is known about its molecular pathology and clinical trials have been extremely difficult to conduct. Development of animal models for rare diseases like angiosarcoma is critical to improve our understanding of tumorigenesis and to test novel treatment regimens...
May 15, 2018: Oncotarget
Atul Vijay Palkar, Ankit Gupta, Yonatan Greenstein, Eric Gottesman
Primary cardiac angiosarcoma is a rare disease with a dismal prognosis. We report a case of a 50-year-old man who presented with haemoptysis, cough and worsening dyspnoea. An intracardiac mass was visualised on echocardiogram. He was treated for diffuse alveolar haemorrhage and acute respiratory distress syndrome but died from refractory hypoxaemic respiratory failure leading to cardiac arrest. The diagnosis of primary cardiac angiosarcoma with haemorrhagic pulmonary metastases leading to diffuse alveolar damage was confirmed on autopsy...
June 4, 2018: BMJ Case Reports
Lindsey Winer, Francisco I Macedo, Abdullah Alfawaz, Antonio Sommariva, Giovanni Cecchetto, Holly L Neville, Mecker G Möller
The management of pediatric abdominopelvic angiosarcoma remains unclear due to limited clinical experience. Herein, we presented the first 2 pediatric patients with abdominal angiosarcoma who were treated with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) after neoadjuvant therapy. The first patient is alive with recurrent disease at 1-year follow-up and the second patient remains disease free after 1 year. CRS and HIPEC should be considered as a therapeutic option in the management of pediatric abdominal angiosarcomas...
May 31, 2018: Journal of Pediatric Hematology/oncology
Tchin Darré, Mazamaesso Tchaou, Boyodi Tchangaï, Fousseni Alassani, Sassil Daré, Gado Napo-Koura
No abstract text is available yet for this article.
June 2, 2018: Journal of Gastrointestinal Cancer
Shaoyun Cheng, Yanxiang Cui, Lin Fan, Xiaofeng Mu, Yuzhong Hua
Understanding the function and molecular relevance of distinct miRNAs in endothelial cells (ECs) paves avenues for possible therapeutic intervention by targeting epigenetic mechanisms in vascular endothelial dysfunction, one of the major complications of type 2 diabetes mellitus (T2DM). MiR-342-3p, an obesity-associated miRNA, has recently been shown to be significantly upregulated in human angiosarcoma compared to benign hemangioma, indicating its potential involvement as a proangiogenic factor. Herein, we show that endothelial miR-342-3p expression was significantly compromised in T2DM organisms and this inhibition powerfully blocked vasculogenesis in vivo by repressing endothelial proliferation and migration...
May 28, 2018: Biochemical and Biophysical Research Communications
A Keykhosravi, M Neamatshahi, R Mahmoodi, E Navipour
Background: Skin health has become a worldwide concern. Most of the studies investigated the effect of mobile phone radiation on DNA and animals, but a few studies were carried out about skin diseases in mobile phone and tablet users. Few systematic studies have examined the relationship between mobile phone exposure and skin diseases. Methods: We evaluated the association between mobile phones and tablets and skin diseases. We checked databases including PubMed, Scopus, Springer, Cochrane, and Google Scholar from 1995 to 2013...
2018: Advances in Medicine
Yung Lyou, Emily Barber, Rita Mehta, Thomas Lee, Wamda Goreal, Ritesh Parajuli
In the last couple of decades, breast conservation therapy, which utilizes a combination of surgery, radiotherapy, and endocrine or chemotherapy, has become the standard of care for treating early-stage breast cancer. This practice has been greatly beneficial in the improvement of the patient's quality of life but has also led to the increased use of radiotherapy and associated soft-tissue sarcomas, with angiosarcoma being the most common malignancy. Radiation-associated angiosarcoma (RAS) of the breast is a rare phenomenon, which has been reported to occur in approximately 0...
January 2018: Case Reports in Oncology
Nilgün Yılmaz Demirci, Merve Güleryüz, Elif Kolay
No abstract text is available yet for this article.
May 22, 2018: Archivos de Bronconeumología
Simon F Roy, Feras M Ghazawi, Abeer Alsarheed, Katherine D Lach, Kevin Watters, Elizabeth O'Brien
No abstract text is available yet for this article.
May 24, 2018: International Journal of Dermatology
Ngoc T Hoang, Luis A Acevedo, Michael J Mann, Bhairavi Tolani
Soft-tissue sarcomas are rare malignant tumors arising from connective tissues and have an overall incidence of about five per 100,000 per year. While this diverse family of malignancies comprises over 100 histological subtypes and many molecular aberrations are prevalent within specific sarcomas, very few are therapeutically targeted. Instead of utilizing molecular signatures, first-line sarcoma treatment options are still limited to traditional surgery and chemotherapy, and many of the latter remain largely ineffective and are plagued by disease resistance...
2018: Cancer Management and Research
Isabelle Ray-Coquard, Delphine Serre, Peter Reichardt, Javier Martín-Broto, Sebastian Bauer
Management of soft tissue sarcoma is increasingly subtype-dependent. Surgery is recommended for uterine leiomyosarcoma, with trabectedin being the preferred option for advanced disease when the treatment goal is long-term tumor stabilization. Liposarcoma subgroups are characterized by distinctive morphologies and genetics, different patterns of disease progression and clinical behavior, and variable responses to treatment. Genetic analysis of sarcomas has provided insights into pathogenesis with potential for developing new molecular targets...
May 2018: Future Oncology
Christina Mitteldorf, Mar Llamas-Velasco, Hans-Joachim Schulze, Kai-Martin Thoms, Thomas Mentzel, Michael Tronnier, Heinz Kutzner
BACKGROUND: We investigated two cases of deceptively bland cutaneous angiosarcoma, which showed a uniform clinical presentation with a rapidly growing tumor on the nose. It remains unclear whether this was a primary cutaneous manifestation or a metastasis. Both tumors initially presented a high histologic overlap with a benign vascular tumor. The diagnosis was primarily based on the rapidly progressing clinical course and on the results of the staging procedures. METHODS: Immunohistochemical stains were performed for cytokeratin (AE1/AE3 and MNF116), CD31, ERG, CD34(HPCA1/my10), D2-40/podoplanin, LYVE-1, Ki67, PHH3, αSMA(1A4), MYC, FOS-B, CAMTA-1, TFE-3, WT1, nestin, VEGFR-2(KDR), VEGFR-3(FLT4), HHV8...
May 15, 2018: Journal of Cutaneous Pathology
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