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https://www.readbyqxmd.com/read/29349694/endoscopic-ultrasound-guided-rendezvous-technique-for-failed-biliary-cannulation-in-benign-and-resectable-malignant-biliary-disorders
#1
Hideyuki Shiomi, Kentaro Yamao, Noriyuki Hoki, Takeshi Hisa, Takeshi Ogura, Kosuke Minaga, Atsuhiro Masuda, Kazuya Matsumoto, Hironari Kato, Hideki Kamada, Daisuke Goto, Hajime Imai, Mamoru Takenaka, Chishio Noguchi, Hidefumi Nishikiori, Yasutaka Chiba, Hiromu Kutsumi, Masayuki Kitano
BACKGROUND: Endoscopic ultrasound-guided rendezvous technique (EUS-RV) has emerged as an effective salvage method for unsuccessful biliary cannulation. However, its application for benign and resectable malignant biliary disorders has not been fully evaluated. AIMS: To assess the efficacy and safety of EUS-RV for benign and resectable malignant biliary disorders. METHODS: This was a multicenter prospective study from 12 Japanese referral centers...
January 18, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29342459/risk-factors-and-clinical-features-in-cashew-nut-oral-food-challenges
#2
Takashi Inoue, Kiyotake Ogura, Kyohei Takahashi, Makoto Nishino, Tomoyuki Asaumi, Noriyuki Yanagida, Sakura Sato, Motohiro Ebisawa
BACKGROUND: Cashew nuts (CN) are capable of causing severe allergic reactions. However, little has been reported about the details of CN oral food challenges (OFC). METHODS: CN-specific IgE (sIgE) levels were measured for 1 year in 66 patients who underwent an OFC with >3 g CN for diagnosis or confirmation of tolerance acquisition between June 2006 and August 2014. We retrospectively analyzed the OFC and patient background. RESULTS: The median (IQR) age of the 66 patients (48 boys/men and 18 girls/women) was 7...
January 18, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29339650/oral-immunotherapy-in-japanese-children-with-anaphylactic-peanut-allergy
#3
Ken-Ichi Nagakura, Sakura Sato, Noriyuki Yanagida, Makoto Nishino, Tomoyuki Asaumi, Kiyotake Ogura, Motohiro Ebisawa
BACKGROUND: Reports on oral immunotherapy (OIT) for anaphylactic food allergy are lacking. We investigated the efficacy and safety of peanut OIT for anaphylactic patients. METHODS: We enrolled 22 peanut anaphylactic patients who underwent OIT between 2011 and 2013, all of whom demonstrated anaphylaxis during a baseline double-blind, placebo-controlled food challenge. After starting in-hospital OIT, participants gradually increased ingestion to 795 mg of peanut protein per day at home and then took a maintenance dose (795 mg) daily...
January 16, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29329478/migrated-endoclip-removal-after-cholecystectomy-under-digital-single-operator-cholangioscopy-guidance
#4
Takeshi Ogura, Atsushi Okuda, Akira Miyano, Nobu Nishioka, Kazuhide Higuchi
No abstract text is available yet for this article.
January 12, 2018: Endoscopy
https://www.readbyqxmd.com/read/29328976/pattern-of-programmed-cell-death-ligand-1-expression-and-cd8-positive-t-cell-infiltration-before-and-after-chemoradiotherapy-in-rectal-cancer
#5
Atsushi Ogura, Takashi Akiyoshi, Noriko Yamamoto, Hiroshi Kawachi, Yuichi Ishikawa, Seiichi Mori, Koji Oba, Masato Nagino, Yosuke Fukunaga, Masashi Ueno
BACKGROUND: The synergistic effect of combining immune checkpoint inhibitors with radiotherapy was reported recently, but there are few studies on programmed cell death-ligand 1 (PD-L1) expression in rectal cancer treated by preoperative chemoradiotherapy (CRT). The aim of the present study was to investigate the PD-L1 expression status before and after CRT and its association with clinicopathological characteristics and recurrence in rectal cancer. METHODS: Immunostainings of PD-L1 and CD8 were performed in 287 patients with rectal cancer treated by CRT...
January 9, 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29324782/mafb-is-dispensable-for-the-fetal-testis-morphogenesis-and-the-maintenance-of-spermatogenesis-in-adult-mice
#6
Hossam H Shawki, Hisashi Oishi, Toshiaki Usui, Yu Kitadate, Walaa A Basha, Ahmed M Abdellatif, Kazunori Hasegawa, Risa Okada, Keiji Mochida, Hany A El-Shemy, Masafumi Muratani, Atsuo Ogura, Shosei Yoshida, Satoru Takahashi
The transcription factor MAFB is an important regulator of the development and differentiation of various organs and tissues. Previous studies have shown that MAFB is expressed in embryonic and adult mouse testes and is expected to act as the downstream target of retinoic acid (RA) to initiate spermatogenesis. However, its exact localization and function remain unclear. Here, we localized MAFB expression in embryonic and adult testes and analyzed its gene function using Mafb-deficient mice. We found that MAFB and c-MAF are the only large MAF transcription factors expressed in testes, while MAFA and NRL are not...
2018: PloS One
https://www.readbyqxmd.com/read/29309623/rbm10-regulates-inflammation-development-via-alternative-splicing-of-dnmt3b
#7
Toru Atsumi, Hironao Suzuki, Jing-Jing Jiang, Yuko Okuyama, Ikuma Nakagawa, Mitsutoshi Ota, Yuki Tanaka, Takuto Ohki, Kokichi Katsunuma, Koichi Nakajima, Yoshinori Hasegawa, Osamu Ohara, Hideki Ogura, Yasunobu Arima, Daisuke Kamimura, Masaaki Murakami
Rbm10 is a RNA binding protein that regulates alternative splicing, but its role in inflammation is not well defined. Here we show that Rbm10 controls appropriate splicing of Dnmt3b, a DNA methyltransferase, to regulate the activity of NFκB-responsive promoters and consequently inflammation development. Rbm10 deficiency suppressed NFκB-mediated responses in vivo and in vitro. Mechanistic analysis showed that Rbm10 deficiency decreased promoter recruitment of NFκB, with increased DNA methylation of the promoter regions in NFκB-responsive genes...
December 22, 2017: International Immunology
https://www.readbyqxmd.com/read/29299166/early-morphological-change-for-predicting-outcome-in-metastatic-colorectal-cancer-after-regorafenib
#8
Hiroyuki Arai, Kunihisa Miyakawa, Tadamichi Denda, Takuro Mizukami, Yoshiki Horie, Naoki Izawa, Mami Hirakawa, Takashi Ogura, Takashi Tsuda, Yu Sunakawa, Takako Eguchi Nakajima
Background and Objective: It is unclear whether early morphological change (EMC) is a predictive marker for regorafenib in metastatic colorectal cancer (mCRC). Therefore, the present study investigated whether EMC can predict the outcome of mCRC patients receiving regorafenib. Results: This study evaluated 68 patients. Among 52 patients with lung metastasis, 16 (31%) had cavity formation (CF). The median progression-free survival (PFS) and overall survival (OS) in patients with/without CF were 4...
December 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/29285566/suppression-of-aortic-expansion-and-contractile-recovery-in-a-rat-abdominal-aortic-aneurysm-model-by-biodegradable-gelatin-hydrogel-sheet-incorporating-basic-fibroblast-growth-factor
#9
Norikazu Kawai, Hisashi Iwata, Katsuya Shimabukuro, Narihiro Ishida, Hiroki Ogura, Etsuji Umeda, Kiyoshi Doi
Biodegradable gelatin hydrogel sheet (BGHS) incorporating basic fibroblast growth factor (bFGF) may inhibit the progression of abdominal aortic aneurysm (AAA). We investigated whether AAA in a rat model treated with BGHS soaked with bFGF can suppress aortic expansion and recover the contractile response of aneurysmal aortic wall. Experimental AAA was induced in 10-week-old male Sprague-Dawley rats with intra-aortic elastase infusion. Aortas of these rats were assigned to 4 groups (n = 6 each) as follows: Control group, aortas infused with saline; Elastase only group, aortas infused with elastase; Hydrogel group, aortas wrapped with saline-soaked BGHS after elastase infusion; and bFGF group, aortas wrapped with bFGF (100 μg)-soaked BGHS after elastase infusion...
December 28, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/29285377/elevated-neutrophil-to-lymphocyte-ratio-is-associated-with-nutritional-impairment-immune-suppression-resistance-to-s-1-plus-cisplatin-and-poor-prognosis-in-patients-with-stage-iv-gastric-cancer
#10
Kenji Gonda, Masahiko Shibata, Yu Sato, Maria Washio, Hiroyuki Takeshita, Hirofumi Shigeta, Michikazu Ogura, Shinichi Oka, Shinich Sakuramoto
Gastric cancer continues to be a major cause of morbidity and mortality worldwide. Recently, there has been a growing interest in the host inflammatory response and there is increasing evidence that the neutrophil to lymphocyte ratio (NLR), which is a useful marker of systemic inflammation, can be an effective prognostic indicator in various types of malignant diseases. A total of 110 patients with stage IV gastric cancer who received chemotherapy of S-1 plus cisplatin were enrolled in this study. Eleven patients did not complete four cycles of the chemotherapy...
December 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29280937/efficacy-and-safety-of-intravitreal-aflibercept-and-ranibizumab-in-asian-patients-with-neovascular-age-related-macular-degeneration-subgroup-analyses-from-the-view-trials
#11
Tien Yin Wong, Chui Ming Gemmy Cheung, Timothy Y Y Lai, Shih-Jen Chen, Won Ki Lee, Young Hee Yoon, Tomohiro Iida, Claudia Tueckmantel, Olaf Sowade, Yuichiro Ogura
PURPOSE: To assess the treatment effect of intravitreal aflibercept and ranibizumab in Asian patients with neovascular age-related macular degeneration. METHODS: We evaluated data from VIEW 1 and VIEW 2, comparing functional and morphologic outcomes at Week 96 between intravitreal aflibercept 2 mg monthly (2q4) or 2 mg bimonthly after 3 initial monthly doses (2q8) versus ranibizumab 0.5 mg monthly among Asian patients (n = 269) and between Asian and white patients (n = 2044)...
December 26, 2017: Retina
https://www.readbyqxmd.com/read/29279821/submandibular-sialolithiasis-with-ct-and-scintigraphy-ct-values-and-salivary-gland-excretion-in-the-submandibular-glands
#12
Ichiro Ogura, Kazuhide Hayama, Mikiko Sue, Takaaki Oda, Yoshihiko Sasaki
Purpose: Sialolithiasis is one of the most prevalent large obstructive disorders of the submandibular glands. The aim of this study was to investigate submandibular sialolithiasis with computed tomography (CT) and scintigraphy, with a particular focus on the relationship between CT values of the submandibular glands and their excretion rate. Materials and Methods: Fifteen patients with submandibular sialolithiasis who underwent CT and salivary gland scintigraphy were included in this study...
December 2017: Imaging Science in Dentistry
https://www.readbyqxmd.com/read/29279503/lung-metastases-from-bile-duct-adenocarcinoma-mimicking-chronic-airway-infection-and-causing-diagnostic-difficulty
#13
Mitsuo Sato, Shotaro Okachi, Jun Fukihara, Yoshie Shimoyama, Keiko Wakahara, Toshihiro Sakakibara, Tetsunari Hase, Yasuharu Onishi, Yasuhiro Ogura, Osamu Maeda, Yoshinori Hasegawa
We herein report a case of lung metastases with unusual radiological appearances that mimicked those of chronic airway infection, causing diagnostic difficulty. A 60-year-old woman who underwent liver transplantation from a living donor was incidentally diagnosed with bile duct adenocarcinoma after a histopathological analysis of her explanted liver. Six months later, chest computed tomography (CT) revealed bilateral bronchogenic dissemination that had gradually worsened, suggesting chronic airway infection...
December 27, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29276662/-ogura-based-cms-lines-with-different-nuclear-backgrounds-of-cabbage-revealed-substantial-diversity-at-morphological-and-molecular-levels
#14
Chander Parkash, Sandeep Kumar, Rajender Singh, Ajay Kumar, Satish Kumar, Shyam Sundar Dey, Reeta Bhatia, Raj Kumar
A comprehensive study on characterization and genetic diversity analysis was carried out in 16 'Ogura'-based 'CMS' lines of cabbage using 14 agro-morphological traits and 29 SSR markers. Agro-morphological characterization depicted considerable variations for different horticultural traits studied. The genotype, ZHA-2, performed better for most of the economically important quantitative traits. Further, gross head weight (0.76), head length (0.60) and head width (0.83) revealed significant positive correlation with net head weight...
January 2018: 3 Biotech
https://www.readbyqxmd.com/read/29247372/smoking-related-lung-abnormalities-on-computed-tomography-images-comparison-with-pathological-findings
#15
REVIEW
Tae Iwasawa, Tamiko Takemura, Takashi Ogura
Smoking-related lung abnormalities are now an increasing public health concern. According to the findings of large-cohort studies, approximately 8% of smokers have interstitial lung abnormalities, which are associated with a relatively high risk of all-cause mortality. We reviewed the radiological and pathological findings of smoking-related interstitial lung diseases, such as respiratory bronchiolitis-interstitial lung disease, desquamative interstitial pneumonia, and airspace enlargement with fibrosis. We have also discussed the histological basis of unclassifiable interstitial pneumonia in smokers, which exhibits airway-centered cystic lesions with fibrosis...
December 15, 2017: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/29232411/rev-erb-agonist-improves-adverse-cardiac-remodeling-and-survival-in-myocardial-infarction-through-an-anti-inflammatory-mechanism
#16
Endin Nokik Stujanna, Nobuyuki Murakoshi, Kazuko Tajiri, DongZhu Xu, Taizo Kimura, Rujie Qin, Duo Feng, Saori Yonebayashi, Yukino Ogura, Fumi Yamagami, Akira Sato, Akihiko Nogami, Kazutaka Aonuma
Rev-erb α, known as nuclear receptor 1D1 (NR1D1), regulates circadian rhythm, modulates glucose and lipid metabolism, and inflammatory response. However, little is known about the effect of Rev-erb agonist on the progression of myocardial infarction (MI) and heart failure. To investigate it, wild-type male mice underwent sham-operation or permanent ligation of the left anterior descending coronary artery to create MI model. Rev-erb agonist SR9009 (100 mg/kg/day) or vehicle was intraperitoneally administered...
2017: PloS One
https://www.readbyqxmd.com/read/29225065/an-unbiased-data-driven-age-related-structural-brain-parcellation-for-the-identification-of-intrinsic-brain-volume-changes-over-the-adult-lifespan
#17
Epifanio Bagarinao, Hirohisa Watanabe, Satoshi Maesawa, Daisuke Mori, Kazuhiro Hara, Kazuya Kawabata, Noritaka Yoneyama, Reiko Ohdake, Kazunori Imai, Michihito Masuda, Takamasa Yokoi, Aya Ogura, Toshihiko Wakabayashi, Masafumi Kuzuya, Norio Ozaki, Minoru Hoshiyama, Haruo Isoda, Shinji Naganawa, Gen Sobue
This study aims to elucidate age-related intrinsic brain volume changes over the adult lifespan using an unbiased data-driven structural brain parcellation. Anatomical brain images from a cohort of 293 healthy volunteers ranging in age from 21 - 86 years were analyzed using independent component analysis (ICA). ICA-based parcellation identified 192 component images, of which 174 (90.6%) showed a significant negative correlation with age and with some components being more vulnerable to aging effects than others...
December 7, 2017: NeuroImage
https://www.readbyqxmd.com/read/29222727/a-method-for-facilitating-the-seed-germination-of-a-mycoheterotrophic-orchid-gastrodia-pubilabiata-using-decomposed-leaf-litter-harboring-a-basidiomycete-fungus-mycena-sp
#18
Kana Higaki, Kento Rammitsu, Yumi Yamashita, Tomohisa Yukawa, Yuki Ogura-Tsujita
BACKGROUND: Mycoheterotrophic plants are one of the most difficult plant groups to conserve because they are entirely dependent on symbiotic fungi. Establishment of viable culture systems would greatly aid their conservation. We describe a simple culture system for the mycoheterotrophic orchid, Gastrodia pubilabiata, that does not require laboratory facilities. The orchid is symbiotic with leaf-litter-decomposing fungi. RESULTS: Gastrodia pubilabiata seeds were incubated in plastic boxes or glass bottles filled with leaf litter collected from the natural habitat of the species...
December 8, 2017: Botanical Studies (Taipei, Taiwan)
https://www.readbyqxmd.com/read/29222435/long-term-maintenance-of-peripheral-blood-derived-human-nk-cells-in-a-novel-human-il-15-transgenic-nog-mouse
#19
Ikumi Katano, Chiyoko Nishime, Ryoji Ito, Tsutomu Kamisako, Takuma Mizusawa, Yuyo Ka, Tomoyuki Ogura, Hiroshi Suemizu, Yutaka Kawakami, Mamoru Ito, Takeshi Takahashi
We generated a novel mouse strain expressing transgenic human interleukin-15 (IL-15) using the severe immunodeficient NOD/Shi-scid-IL-2Rγ null (NOG) mouse genetic background (NOG-IL-15 Tg). Human natural killer (NK) cells, purified from the peripheral blood (hu-PB-NK) of normal healthy donors, proliferated when transferred into NOG-IL-15 Tg mice. In addition, the cell number increased, and the hu-PB-NK cells persisted for 3 months without signs of xenogeneic graft versus host diseases (xGVHD). These in vivo-expanded hu-PB-NK cells maintained the original expression patterns of various surface antigens, including NK receptors and killer cell immunoglobulin-like receptor (KIR) molecules...
December 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29220297/local-control-of-soft-tissue-and-bone-sarcomas
#20
Joseph G Crompton, Koichi Ogura, Nicholas M Bernthal, Akira Kawai, Fritz C Eilber
Sarcomas of soft tissue and bone are mesenchymal malignancies that can arise in any anatomic location, most commonly the extremity, retroperitoneum, and trunk. Even for lower grade histologic subtypes, local recurrence can cause significant morbidity and even disease-related death. Although surgery remains the cornerstone of local control, perioperative radiation and systemic therapy are often important adjuvants. This review will summarize the current therapeutic approaches for local control of soft tissue and bone sarcomas...
December 8, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
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