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https://www.readbyqxmd.com/read/28211224/splenectomy-resolves-hemolytic-anemia-caused-by-adenylate-kinase-deficiency
#1
Hidetaka Niizuma, Hitoshi Kanno, Atsushi Sato, Hiromi Ogura, Masue Imaizumi
No abstract text is available yet for this article.
February 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28211100/safety-and-feasibility-of-heated-egg-yolk-challenge-for-children-with-egg-allergies
#2
Noriyuki Yanagida, Sakura Sato, Tomoyuki Asaumi, Kiyotake Ogura, Magnus P Borres, Motohiro Ebisawa
BACKGROUND: Hen's egg allergy is a frequent cause of childhood food allergy. Egg yolk is used in various commonly consumed foods; if children with allergy to hen's egg could eat heated egg yolk, their quality of life (QOL) would improve. No reports exist regarding oral food challenges (OFCs) for heated egg yolk. We aimed to clarify whether pediatric patients allergic to hen's egg could consume heated egg yolk. METHODS: Data from pediatric patients who had undergone OFCs for heated egg yolk were evaluated retrospectively...
February 16, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28210515/cystic-endometrioma-with-coexisting-fibroma-originating-in-a-supernumerary-ovary-in-the-rectovaginal-pouch
#3
Daiki Ogishima, Asumi Sakaguchi, Hiroko Kodama, Kanako Ogura, Ayako Miwa, Yayoi Sugimori, Shozo Matuoka, Toshiharu Matsumoto
A supernumerary ovary is an exceedingly rare disorder, in which the structure containing ovarian tissue is located at some distance from the normally placed ovary. 16 cases of endometriosis or tumors originating in a supernumerary ovary have been published in the English literature, but no case of coexisting endometriosis and a tumor has been published. We present the case of a 40-year-old female with cystic endometrioma with coexisting fibroma originating in a supernumerary ovary in the rectovaginal pouch...
2017: Case Reports in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28210068/use-of-an-arm-weight-bearing-combined-with-upper-limb-reaching-apparatus-to-facilitate-motor-paralysis-recovery-in-an-incomplete-spinal-cord-injury-patient-a-single-case-report
#4
Takashi Hoei, Kazumi Kawahira, Hidefumi Fukuda, Keizo Sihgenobu, Megumi Shimodozono, Tadashi Ogura
[Purpose] Training using an arm weight-bearing device combined with upper-limb reaching apparatus to facilitate motor paralysis recovery, named the "Reaching Robot", as well as Repetitive Facilitation Exercise were applied to a patient with severe impairment of the shoulder and elbow due to incomplete spinal cord injury and the effects were examined. [Subjects and Methods] A 66-year-old man with incomplete spinal cord injury participated in an upper extremity rehabilitation program involving a Reaching Robot...
January 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28207938/comparison-of-clinical-and-pathological-features-of-lung-lesions-of-systemic-igg4-related-disease-and-idiopathic-multicentric-castleman-s-disease
#5
Yasuhiro Terasaki, Shinichro Ikushima, Shoko Matsui, Akira Hebisawa, Yasunori Ichimura, Shinyu Izumi, Masuo Ujita, Machiko Arita, Keisuke Tomii, Youko Komase, Isoko Owan, Tetsuji Kawamura, Yasuo Matsuzawa, Miho Murakami, Hiroshi Ishimoto, Hiroshi Kimura, Masashi Bando, Norihiro Nishimoto, Yoshinori Kawabata, Yuh Fukuda, Takashi Ogura
AIMS: The lung lesion (IgG4-L) of IgG4-related disease (IgG4-RD) is a condition that occurs together with IgG4-RD and often mimics the lung lesion (iMCD-L) of idiopathic multicentric Castleman's disease (iMCD). Because no clinical and pathological studies had previously compared features of these diseases, we undertook this comparison with clinical and histological data. METHODS AND RESULTS: Nine patients had IgG4-L (high levels of serum IgG4 and of IgG4(+) cells in lung specimens; typical extrapulmonary manifestations)...
February 16, 2017: Histopathology
https://www.readbyqxmd.com/read/28201801/impact-of-geriatric-factors-on-surgical-and-prognostic-outcomes-in-elderly-patients-with-soft-tissue-sarcoma
#6
Yusuke Tsuda, Koichi Ogura, Eisuke Kobayashi, Toru Hiruma, Shintaro Iwata, Naofumi Asano, Akira Kawai, Hirokazu Chuman, Takeshi Ishii, Hideo Morioka, Hiroshi Kobayashi, Hirotaka Kawano
No abstract text is available yet for this article.
February 15, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28199095/interrelationship-among-the-fe-his-bond-strengths-oxygen-affinities-and-intersubunit-hydrogen-bonding-changes-upon-ligand-binding-in-%C3%AE-subunit-of-human-hemoglobin-the-alkaline-bohr-effect
#7
Shigenori Nagatomo, Miki Okumura, Kazuya Saito, Takashi Ogura, Teizo Kitagawa, Masako Nagai
Regulation of oxygen affinity of human adult hemoglobin (Hb A) at high pH, known as the alkaline Bohr effect, is essential to its physiological function. In this study structural mechanisms of the alkaline Bohr effect and pH-dependent O2 affinity changes are investigated with (1)H NMR, and visible- and UV-resonance Raman spectra of mutant Hbs, Hb M Iwate (αH87Y) and Hb M Boston (αH58Y). It was found that even though the O2 binding to the α subunits is forbidden in the mutant Hbs, the O2 affinity became higher at alkaline pH than at neutral pH and concomitantly, the Fe-His stretching frequency of the β subunits was shifted to higher values...
February 15, 2017: Biochemistry
https://www.readbyqxmd.com/read/28198119/in%C3%A2-vivo-gold-complex-catalysis-within-live-mice
#8
Kazuki Tsubokura, Kenward K H Vong, Ambara R Pradipta, Akihiro Ogura, Sayaka Urano, Tsuyoshi Tahara, Satoshi Nozaki, Hirotaka Onoe, Yoichi Nakao, Regina Sibgatullina, Almira Kurbangalieva, Yasuyoshi Watanabe, Katsunori Tanaka
Metal complex catalysis within biological systems is largely limited to cell and bacterial systems. In this work, a glycoalbumin-Au(III) complex was designed and developed that enables organ-specific, localized propargyl ester amidation with nearby proteins within live mice. The targeted reactivity can be imaged through the use of Cy7.5- and TAMRA-linked propargyl ester based fluorescent probes. This targeting system could enable the exploitation of other metal catalysis strategies for biomedical and clinical applications...
February 15, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28196907/acetylation-dependent-regulation-of-mdm2-e3-ligase-activity-dictates-its-oncogenic-function
#9
Naoe T Nihira, Kohei Ogura, Kouhei Shimizu, Brian J North, Jinfang Zhang, Daming Gao, Hiroyuki Inuzuka, Wenyi Wei
Abnormal activation of the oncogenic E3 ubiquitin ligase murine double minute 2 (MDM2) is frequently observed in human cancers. By ubiquitinating the tumor suppressor p53 protein, which leads to its proteasome-mediated destruction, MDM2 limits the tumor-suppressing activity of p53. On the other hand, by ubiquitinating itself, MDM2 targets itself for destruction and promotes the p53 tumor suppressor pathway, a process that can be antagonized by the deubiquitinase herpesvirus-associated ubiquitin-specific protease (HAUSP)...
February 14, 2017: Science Signaling
https://www.readbyqxmd.com/read/28195201/crispr-cas9-mediated-genome-editing-in-wild-derived-mice-generation-of-tamed-wild-derived-strains-by-mutation-of-the-a-nonagouti-gene
#10
Michiko Hirose, Ayumi Hasegawa, Keiji Mochida, Shogo Matoba, Yuki Hatanaka, Kimiko Inoue, Tatsuhiko Goto, Hideki Kaneda, Ikuko Yamada, Tamio Furuse, Kuniya Abe, Yoshihisa Uenoyama, Hiroko Tsukamura, Shigeharu Wakana, Arata Honda, Atsuo Ogura
Wild-derived mice have contributed to experimental mouse genetics by virtue of their genetic diversity, which may help increase the chance of identifying novel modifier genes responsible for specific phenotypes and diseases. However, gene targeting using wild-derived mice has been unsuccessful because of the unavailability of stable embryonic stem cells. Here, we report that CRISPR/Cas9-mediated gene targeting can be applied to the Japanese wild-derived MSM/Ms strain (Mus musculus molossinus). We targeted the nonagouti (a) gene encoding the agouti protein that is localized in hair and the brain...
February 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28194443/sustained-inflammation-after-pericyte-depletion-induces-irreversible-blood-retina-barrier-breakdown
#11
Shuntaro Ogura, Kaori Kurata, Yuki Hattori, Hiroshi Takase, Toshina Ishiguro-Oonuma, Yoonha Hwang, Soyeon Ahn, Inwon Park, Wataru Ikeda, Sentaro Kusuhara, Yoko Fukushima, Hiromi Nara, Hideto Sakai, Takashi Fujiwara, Jun Matsushita, Masatsugu Ema, Masanori Hirashima, Takashi Minami, Masabumi Shibuya, Nobuyuki Takakura, Pilhan Kim, Takaki Miyata, Yuichiro Ogura, Akiyoshi Uemura
In the central nervous system, endothelial cells (ECs) and pericytes (PCs) of blood vessel walls cooperatively form a physical and chemical barrier to maintain neural homeostasis. However, in diabetic retinopathy (DR), the loss of PCs from vessel walls is assumed to cause breakdown of the blood-retina barrier (BRB) and subsequent vision-threatening vascular dysfunctions. Nonetheless, the lack of adequate DR animal models has precluded disease understanding and drug discovery. Here, by using an anti-PDGFRβ antibody, we show that transient inhibition of the PC recruitment to developing retinal vessels sustained EC-PC dissociations and BRB breakdown in adult mouse retinas, reproducing characteristic features of DR such as hyperpermeability, hypoperfusion, and neoangiogenesis...
February 9, 2017: JCI Insight
https://www.readbyqxmd.com/read/28190756/organic-anion-transporting-polypeptide-oatp-2b1-contributes-to-the-cellular-uptake-of-theaflavin
#12
Ayuko Kondo, Katsuya Narumi, Jiro Ogura, Ai Sasaki, Keisuke Yabe, Taku Kobayashi, Ayako Furugen, Masaki Kobayashi, Ken Iseki
Organic anion-transporting polypeptide (OATP) 2B1 has been reported in the apical membranes of the human small intestinal epithelium, where it contributes to the intestinal absorption of pharmacologically active drugs. To investigate the potential for OATP2B1-mediated drug-food interactions, the effects of several polyphenolic compounds on OATP2B1-mediated estrone-3-sulfate (E3S) transport were studied by using OATP2B1-expressing HEK293 cells. Our results showed that some compounds, especially theaflavin, were strong inhibitors of OATP2B1-mediated E3S uptake...
November 22, 2016: Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/28181704/evaluation-of-the-safety-of-endoscopic-radiofrequency-ablation-for-malignant-biliary-stricture-using-a-digital-peroral-cholangioscope-with-videos
#13
Takeshi Ogura, Saori Onda, Tastsushi Sano, Wataru Takagi, Astushi Okuda, Akira Miyano, Nobu Nishioka, Miyuki Imanishi, Mio Amano, Daisuke Masuda, Kazuhide Higuchi
OBJECTIVES: The clinical impact of catheter based radiofrequency ablation (RFA) under ERCP guidance has been recently reported, however severe adverse events have also been noted. If tumor is not present in the biliary tract, severe adverse events such as perforation or bleeding due to vessel injury around the biliary tract may occur. In addition, the effectiveness of RFA may not be sufficient based solely on radiographic guidance. The aim of this study was to evaluate the actual feasibility of intraductal RFA by peroral cholangioscope (POCS) evaluation before/after RFA...
February 9, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/28179385/minor-traumatic-retroclival-epidural-haematoma-in-an-adult
#14
Toshihide Izumida, Kenichi Ogura
No abstract text is available yet for this article.
February 8, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28175331/long-term-survivors-of-primary-central-nervous-system-lymphoma
#15
Ryuya Yamanaka, Ken Morii, Masakazu Sano, Jumpei Homma, Naoki Yajima, Yoshihiro Tsukamoto, Ryouske Ogura, Manabu Natsumeda, Hiroshi Aoki, Katsuhiko Akiyama, Takafumi Saitoh, Hiroaki Hondoh, Atsushi Kawaguchi, Hitoshi Takahashi, Yukihiko Fujii
No abstract text is available yet for this article.
February 23, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28171877/a-multicenter-randomized-controlled-study-of-antioxidant-supplementation-with-lutein-for-chronic-central-serous-chorioretinopathy
#16
Ari Shinojima, Miki Sawa, Tetsuju Sekiryu, Yuji Oshima, Ryusaburo Mori, Chikako Hara, Yukinori Sugano, Aki Kato, Hitomi Asato, Mitsuko Yuzawa, Fumi Gomi, Yuichiro Ogura, Tatsuro Ishibashi, Tomoaki Nanri, Tsutomu Yasukawa
PURPOSE: To investigate functional and morphological changes in patients with chronic central serous chorioretinopathy after supplementation with antioxidants containing lutein or a placebo. PROCEDURES: One hundred eyes of 100 patients were randomly divided into 2 groups, one taking tablets with lutein plus other antioxidants and the other taking a placebo for 6 months. Best-corrected visual acuity (BCVA) and the subfoveal fluid height on optical coherence tomography were measured...
February 8, 2017: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/28169355/enhancement-of-5-aminolevulinic-acid-based-fluorescence-detection-of-side-population-defined-glioma-stem-cells-by-iron-chelation
#17
Wenqian Wang, Kouichi Tabu, Yuichiro Hagiya, Yuta Sugiyama, Yasuhiro Kokubu, Yoshitaka Murota, Shun-Ichiro Ogura, Tetsuya Taga
Cancer stem cells (CSCs) are dominantly responsible for tumor progression and chemo/radio-resistance, resulting in tumor recurrence. 5-aminolevulinic acid (ALA) is metabolized to fluorescent protoporphyrin IX (PpIX) specifically in tumor cells, and therefore clinically used as a reagent for photodynamic diagnosis (PDD) and therapy (PDT) of cancers including gliomas. However, it remains to be clarified whether this method could be effective for CSC detection. Here, using flow cytometry-based analysis, we show that side population (SP)-defined C6 glioma CSCs (GSCs) displayed much less 5-ALA-derived PpIX fluorescence than non-GSCs...
February 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28167971/glucose-metabolic-changes-in-the-brain-and-muscles-of-patients-with-nonspecific-neck-pain-treated-by-spinal-manipulation-therapy-a-18-f-fdg-pet-study
#18
Akie Inami, Takeshi Ogura, Shoichi Watanuki, Md Mehedi Masud, Katsuhiko Shibuya, Masayasu Miyake, Rin Matsuda, Kotaro Hiraoka, Masatoshi Itoh, Arlan W Fuhr, Kazuhiko Yanai, Manabu Tashiro
Objective. The aim of this study was to investigate changes in brain and muscle glucose metabolism that are not yet known, using positron emission tomography with [(18)F]fluorodeoxyglucose ([(18)F]FDG PET). Methods. Twenty-one male volunteers were recruited for the present study. [(18)F]FDG PET scanning was performed twice on each subject: once after the spinal manipulation therapy (SMT) intervention (treatment condition) and once after resting (control condition). We performed the SMT intervention using an adjustment device...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28154765/valgus-slipped-capital-femoral-epiphysis-in-patient-with-hypopituitarism
#19
Yoshihiro Kotoura, Yasuhiro Fujiwara, Tatsuro Hayashida, Koji Murakami, Satoshi Makio, Yuichi Shimizu, Yoshinobu Oka, Wook-Choel Kim, Taku Ogura, Toshikazu Kubo
Slipped capital femoral epiphysis (SCFE) is a common disease of adolescent and the epiphysis is positioned more posteromedially in relation to the femoral neck shaft with varus SCFE; however, posterolateral displacement of the capital epiphysis, valgus SCFE, occurs less frequently. We report a case of valgus SCFE in a 17-year-old boy with hypopituitarism. After falling down, he experienced difficulty in walking. The radiographs were inconclusive; however three-dimensional computed tomography images showed lateral displacement of the epiphysis on the right femoral head...
2017: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/28137498/evaluation-of-urinary-desmosines-as-a-noninvasive-diagnostic-biomarker-in-patients-with-idiopathic-pleuroparenchymal-fibroelastosis-ppfe
#20
Yoshiyuki Oyama, Noriyuki Enomoto, Yuzo Suzuki, Masato Kono, Tomoyuki Fujisawa, Naoki Inui, Yutaro Nakamura, Shigeki Kuroishi, Koshi Yokomura, Mikio Toyoshima, Shiro Imokawa, Keiji Oishi, Satoshi Watanabe, Kazuo Kasahara, Tomohisa Baba, Takashi Ogura, Hiroshi Ishii, Kentaro Watanabe, Yasuhiko Nishioka, Takafumi Suda
BACKGROUND: Pleuroparenchymal fibroelastosis (PPFE) is a rare interstitial pneumonia with upper lobe predominance and fibroelastosis. Although definite diagnosis requires surgical lung biopsy (SLB), SLB is often difficult because of its complications such as refractory pneumothorax. OBJECTIVE: To evaluate urinary desmosines (degradation product of mature elastin) as a novel biomarker in patients with PPFE. METHODS: Biopsy-proven patients with PPFE (n = 14) were prospectively enrolled...
February 2017: Respiratory Medicine
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