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https://www.readbyqxmd.com/read/29454140/weight-management-in-rural-health-clinics-the-midwest-diet-and-exercise-trial
#1
Anna M Gorczyca, Richard A Washburn, Lauren Ptomey, Matthew S Mayo, Debra K Sullivan, Cheryl A Gibson, Robert Lee, Sarah Stolte, Joseph E Donnelly
Obesity prevalence is higher in rural compared to urban residents. Rural health clinics offer a potential venue for delivery of weight management. However, traditional programs require travel to attend on-site meetings which is impractical or inconvenient for rural residents. Clinic staff in most rural settings are unlikely to be trained to provide effective weight management. Remote delivery using group phone conferences (GP) or individual phone calls (IP), by staff associated with rural clinics eliminates the need for travel to attend on-site meetings...
February 14, 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29450800/the-endogenous-subcellular-localisations-of-the-long-chain-fatty-acid-activating-enzymes-acsl3-and-acsl4-in-sarcoma-and-breast-cancer-cells
#2
Yassmeen Radif, Haarith Ndiaye, Vasiliki Kalantzi, Ruth Jacobs, Andrew Hall, Shane Minogue, Mark G Waugh
Fatty acid uptake and metabolism are often dysregulated in cancer cells. Fatty acid activation is a critical step that allows these biomolecules to enter cellular metabolic pathways such as mitochondrial β-oxidation for ATP generation or the lipogenic routes that generate bioactive lipids such as the inositol phospholipids. Fatty acid activation by the addition of coenzyme A is catalysed by a family of enzymes called the acyl CoA synthetase ligases (ACSL). Furthermore, enhanced expression of particular ACSL isoforms, such as ACSL4, is a feature of some more aggressive cancers and may contribute to the oncogenic phenotype...
February 15, 2018: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29450196/recruitment-and-lessons-learned-from-a-community-based-intervention-program-the-learning-families-project-in-hong-kong
#3
Joanna T W Chu, Alice Wan, Sunita M Stewart, Kwok Tung Ng, Tai Hing Lam, Sophia S Chan
Background: Recruitment is central to any research project, and recruitment itself should be well documented and researched. We describe our recruitment efforts for a community-based research project-entitled the Learning Families Project-conducted in Hong Kong. Methods: In collaboration with community stakeholders, residents from a public housing estate were recruited to participate in family programs aimed at enhancing family well-being. Various recruitment strategies were employed including the distribution of 19,200 leaflets, 688 posters, a banner, a kick-off ceremony, 10 promotion activities, 1,000 direct calls, word of mouth, 51 mobile counters, and 10 door-to-door visits...
2018: Frontiers in Public Health
https://www.readbyqxmd.com/read/29447562/overloaded-and-overlooked-improving-resident-advisors-self-care
#4
Whitney Grace McLaughlin
The purpose of this viewpoint is to discuss the lack of research on resident advisor (RA) self-care and how behavioral interventions can be used in housing programs to educate and improve RA self-care. It is essential for live-in housing staff (both professional and paraprofessional) to learn how to develop appropriate strategies that target problem behaviors to improve self-care. An overview of the RA position, the effects of increased demands (i.e., burnout), and the research on self-care behavioral interventions are discussed...
February 15, 2018: Journal of American College Health: J of ACH
https://www.readbyqxmd.com/read/29445588/the-very-experienced-time-honoured-surgeons-vetus-project
#5
Luca Bertolaccini, Piergiorgio Solli, Roberto Crisci, Gaetano Rocco
Senior surgeons who completed their formal surgical training before the video-assisted thoracoscopic surgery (VATS) lobectomy era have had more experience with lobectomy via thoracotomy while their thoracoscopic training background contrasts from younger surgeons. However, this does not seem to have an unfavourable effect on their performance. Despite the literature recognising the critical points of influence of the learning curve for resident surgeons, limited data are focusing on the incremental performance of VATS lobectomy by senior surgeons...
2018: Journal of Visualized Surgery
https://www.readbyqxmd.com/read/29444645/how-to-achieve-the-desired-outcomes-of-advance-care-planning-in-nursing-homes-a-theory-of-change
#6
J Gilissen, L Pivodic, C Gastmans, R Vander Stichele, L Deliens, E Breuer, L Van den Block
BACKGROUND: Advance care planning (ACP) has been identified as particularly relevant for nursing home residents, but it remains unclear how or under what circumstances ACP works and can best be implemented in such settings. We aimed to develop a theory that outlines the hypothetical causal pathway of ACP in nursing homes, i.e. what changes are expected, by means of which processes and under what circumstances. METHODS: The Theory of Change approach is a participatory method of programme design and evaluation whose underlying intention is to improve understanding of how and why a programme works...
February 14, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29441157/oiling-the-gate-a-mobile-application-to-improve-the-admissions-process-from-the-emergency-department-to-an-academic-community-hospital-inpatient-medicine-service
#7
Russell Fung, Jensen Hart Hyde, Mike Davis
The process of admitting patients from the emergency department (ED) to an academic internal medicine (AIM) service in a community teaching hospital is one fraught with variability and disorder. This results in an inconsistent volume of patients admitted to academic versus private hospitalist services and results in frustration of both ED and AIM clinicians. We postulated that implementation of a mobile application (app) would improve provider satisfaction and increase admissions to the academic service. The app was designed and implemented to be easily accessible to ED physicians, regularly updated by academic residents on call, and a real-time source of the number of open AIM admission spots...
2018: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/29440510/educated-natural-killer-cells-show-dynamic-movement-of-the-activating-receptor-nkp46-and-confinement-of-the-inhibitory-receptor-ly49a
#8
Elina Staaf, Per Niklas Hedde, Sunitha Bagawath Singh, Joachim Piguet, Enrico Gratton, Sofia Johansson
Educated natural killer (NK) cells have inhibitory receptors specific for self major histocompatibility complex (MHC) class I molecules and kill cancer cells more efficiently than do NK cells that do not have such receptors (hyporesponsive NK cells). The mechanism behind this functional empowerment through education has so far not been fully described. In addition, distinctive phenotypic markers of educated NK cells at the single-cell level are lacking. We developed a refined version of the image mean square displacement (iMSD) method (called iMSD carpet analysis) and used it in combination with single-particle tracking to characterize the dynamics of the activating receptor NKp46 and the inhibitory receptor Ly49A on resting educated versus hyporesponsive murine NK cells...
February 13, 2018: Science Signaling
https://www.readbyqxmd.com/read/29434282/murine-hematopoietic-stem-cell-reconstitution-potential-is-maintained-by-osteopontin-during-aging
#9
Jin Li, Carmen Carrillo García, Tamara Riedt, Maria Brandes, Sabrina Szczepanski, Peter Brossart, Wolfgang Wagner, Viktor Janzen
In adult mammals, hematopoietic stem cells (HSCs) reside in the bone marrow and are in part regulated by the bone marrow microenvironment, called the stem cell niche. We have previously identified the bone marrow morphogen osteopontin (OPN), which is abundantly present in the bone marrow extracellular matrix, as a negative regulator of the size of the HSC pool under physiological conditions. Here, we study the impact of OPN on HSC function during aging using an OPN-knockout mouse model. We show that during aging OPN deficiency is associated with an increase in lymphocytes and a decline in erythrocytes in peripheral blood...
February 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29425631/combining-spatial-information-and-optimization-for-locating-emergency-medical-service-stations-a-case-study-for-lower-austria
#10
Robert Fritze, Anita Graser, Markus Sinnl
OBJECTIVES: Emergency medical services have been established in many countries all over the world. Good first care improves the outcome of patients in terms of hospital stay duration, chances of full recovery and of treatment costs. In this paper, we present an integrated approach combining spatial information and integer optimization for emergency medical service location planning. The research is motivated by a recent call for bids to restructure the location of emergency medical services in the Austrian federal state of Lower Austria by the local state government...
March 2018: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/29416530/-time-a-web-application-for-obtaining-insights-into-microbial-ecology-using-longitudinal-microbiome-data
#11
Krishanu D Baksi, Bhusan K Kuntal, Sharmila S Mande
Realization of the importance of microbiome studies, coupled with the decreasing sequencing cost, has led to the exponential growth of microbiome data. A number of these microbiome studies have focused on understanding changes in the microbial community over time. Such longitudinal microbiome studies have the potential to offer unique insights pertaining to the microbial social networks as well as their responses to perturbations. In this communication, we introduce a web based framework called 'TIME' (Temporal Insights into Microbial Ecology'), developed specifically to obtain meaningful insights from microbiome time series data...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29414426/investigating-connectivity-in-the-urban-food-landscapes-of-migrant-women-facing-food-insecurity-in-washington-dc
#12
Colleen Hammelman
The survival strategies of migrant women living in urban poverty are embedded in urban food landscapes ('foodscapes') characterized by dynamic social relationships and mobility. Relying on interviews with 31 migrant women in Washington, DC, this paper traces the socio-spatial conditions of their urban foodscapes to show that urban environments inhabited by low-income migrants are dynamic, stretching across multiple neighborhoods as they move throughout the city with social networks to obtain affordable, quality, and culturally appropriate food...
January 31, 2018: Health & Place
https://www.readbyqxmd.com/read/29410799/quantification-of-plasma-cell-dynamics-using-mathematical-modelling
#13
Marcel Mohr, Dirk Hose, Anja Seckinger, Anna Marciniak-Czochra
Plasma cells (PCs) are the main antibody-producing cells in humans. They are long-lived so that specific antibodies against either pathogens or vaccines are produced for decades. PC longevity is attributed to specific areas within the bone marrow micro-environment, the so-called 'niche', providing the cells with required growth and survival factors. With antigen encounters, e.g. infection or vaccination, new PCs are generated and home to the bone marrow where they compete with resident PCs for the niche. We propose a parametrized mathematical model describing healthy PC dynamics in the bone marrow...
January 2018: Royal Society Open Science
https://www.readbyqxmd.com/read/29409795/medicinal-foods-and-beverages-among-maasai-agro-pastoralists-in-northern-tanzania
#14
Casey J Roulette, Efrem-Fred A Njau, Marsha B Quinlan, Robert J Quinlan, Douglas R Call
ETHNOPHARMACOLOGICAL RELEVANCE: Pastoralist Maasai populations of east Africa use several different wild plants as dietary and medicinal additives in beverages (soups and teas), yet little is known about how the plants used and the rationales for use compare and contrast across different Maasai beverages, including how gender specific dietary and health concerns structure patterns of intake. AIM OF THE STUDY: We investigated three Maasai beverages: almajani (tea or herbal infusion); motorí (traditional soup); and okiti (psychoactive herbal tea)...
February 1, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29408460/prevalence-of-and-factors-associated-with-fecal-incontinence-results-from-a-population-based-survey
#15
Stacy B Menees, Christopher V Almario, Brennan M R Spiegel, William D Chey
BACKGROUND & AIMS: Fecal incontinence (FI) is characterized by uncontrolled passage of solid or liquid stool. We aimed to determine the prevalence and severity of FI in a large sample of United States residents. METHODS: We recruited a representative sample of patients in October 2015 to complete the National Gastrointestinal (GI) Survey; a mobile app called MyGiHealth was used to systematically collect data on GI symptoms. FI was defined as accidental leakage of solid or liquid stool...
February 3, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29404880/residues-and-sources-of-organochlorine-pesticides-in-soils-of-elementary-schools-and-communities-in-wenchuan-5-12-earthquake-affected-areas
#16
Qiangbin Zhang, Wei Huang, Xianlei Zhu, Qinping Song, Zhihua Fan
The disinfectants and pesticides extensively used after Wenchuan 5.12 Earthquake on May 12, 2008 (so-called Wenchuan 5.12 Earthquake), for epidemic prevention purpose can raise great concerns of environmental pollution and potential personal exposure. To investigate the soil pollution caused by the intensive application in earthquake-affected areas, surface soil samples from two elementary schools, two communities and two background areas were collected in Beichuan County and Dujiangyan City once per location in spring and in autumn in 2011 and then analyzed by gas chromatography/mass spectrometry for organochlorine pesticides (OCPs)...
February 5, 2018: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/29404572/association-of-rideshare-based-transportation-services-and-missed-primary-care-appointments-a-clinical-trial
#17
Krisda H Chaiyachati, Rebecca A Hubbard, Alyssa Yeager, Brian Mugo, Stephanie Lopez, Elizabeth Asch, Catherine Shi, Judy A Shea, Roy Rosin, David Grande
Importance: Transportation barriers contribute to missed primary care appointments for patients with Medicaid. Rideshare services have been proposed as alternatives to nonemergency medical transportation programs because of convenience and lower costs. Objective: To evaluate the association between rideshare-based medical transportation and missed primary care appointments among Medicaid patients. Design, Setting, and Participants: In a prospective clinical trial, 786 Medicaid beneficiaries who resided in West Philadelphia and were established primary care patients at 1 of 2 academic internal medicine practices located within the same building were included...
February 5, 2018: JAMA Internal Medicine
https://www.readbyqxmd.com/read/29404413/bioid-reveals-novel-proteins-of-the-plasmodium-parasitophorous-vacuole-membrane
#18
Cilly Bernardette Schnider, Damaris Bausch-Fluck, Francis Brühlmann, Volker T Heussler, Paul-Christian Burda
During their development within the vertebrate host, Plasmodium parasites infect hepatocytes and red blood cells. Within these cells, parasites are surrounded by a parasitophorous vacuole membrane (PVM). The PVM plays an essential role for the interaction of parasites with their host cells; however, only a limited number of proteins of this membrane have been identified so far. This is partially because systematic proteomic analysis of the protein content of the PVM has been difficult in the past, due to difficulties encountered in attempts to separate the PVM from other membranes such as the parasite plasma membrane...
January 2018: MSphere
https://www.readbyqxmd.com/read/29402291/evaluating-a-dementia-learning-community-exploratory-study-and-research-implications
#19
Rod Sheaff, Ian Sherriff, Catherine Hagan Hennessy
BACKGROUND: Access times for, the costs and overload of hospital services are an increasingly salient issue for healthcare managers in many countries. Rising demand for hospital care has been attributed partly to unplanned admissions for older people, and among these partly to the increasing prevalence of dementia. The paper makes a preliminary evaluation of the logic model of a Dementia Learning Community (DLC) intended to reduce unplanned hospital admissions from care homes of people with dementia...
February 5, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29401333/recognizing-the-importance-of-leadership-a-recent-graduate-develops-a-corpsman
#20
Joshua D Hartzell, Laura Gilbert
There is a growing interest in leadership development within the field of medicine both within the military and the larger medical community. Recognition of the importance of leadership training during graduate medical education has grown, but many residents and faculty still argue that residency training should focus on clinical skills and medical knowledge. Most graduates of training programs in the military quickly find themselves in formal leadership positions or they must informally lead in their clinical practice...
January 1, 2018: Military Medicine
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