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https://www.readbyqxmd.com/read/28110297/the-technical-report-on-sodium-intake-and-cardiovascular-disease-in-low-and-middle-income-countries-by-the-joint-working-group-of-the-world-heart-federation-the-european-society-of-hypertension-and-the-european-public-health-association
#1
REVIEW
Giuseppe Mancia, Suzanne Oparil, Paul K Whelton, Martin McKee, Anna Dominiczak, Friedrich C Luft, Khalid AlHabib, Fernando Lanas, Albertino Damasceno, Dorairaj Prabhakaran, Giuseppe La Torre, Michael Weber, Martin O'Donnell, Sidney C Smith, Jagat Narula
Ingestion of sodium is essential to health, but excess sodium intake is a risk factor for hypertension and cardiovascular disease. Defining an optimal range of sodium intake in populations has been challenging and controversial. Clinical trials evaluating the effect of sodium reduction on blood pressure have shown blood pressure lowering effects down to sodium intake of less than 1.5 g/day. Findings from these blood pressure trials form the basis for current guideline recommendations to reduce sodium intake to less than 2...
January 21, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28104565/matter-of-will-the-association-between-posttraumatic-stress-symptoms-and-the-will-to-live
#2
Yuval Palgi
The present study examined how posttraumatic-stress-symptoms presented after prolonged traumatic exposure to rocket attacks are related to the perception of the worthiness of life among individuals in the second half of their lives. Additionally, it was questioned whether the subjective evaluation of the time one has left to live affects this relationship. Using an in-region random digit dialing methodology, phone calls made to residents in the south of Israel, we sampled 339 community-dwelling older adults (age range 50-90; M=65...
January 10, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28099883/beta2-adrenergic-signaling-affects-the-phenotype-of-human-cardiac-progenitor-cells-through-emt-modulation
#3
Francesca Pagano, Francesco Angelini, Camilla Siciliano, Julia Tasciotti, Giorgio Mangino, Elena De Falco, Roberto Carnevale, Sebastiano Sciarretta, Giacomo Frati, Isotta Chimenti
Human cardiac progenitor cells (CPCs) offer great promises to cardiac cell therapy for heart failure. Many in vivo studies have shown their therapeutic benefits, paving the way for clinical translation. The 3D model of cardiospheres (CSs) represents a unique niche-like in vitro microenvironment, which includes CPCs and supporting cells. CSs have been shown to form through a process mediated by epithelial-to-mesenchymal transition (EMT). β2-adrenergic signaling significantly affects stem/progenitor cells activation and mobilization in multiple tissues, and crosstalk between β2-adrenergic signaling and EMT processes has been reported...
January 15, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28098778/bone-niches-hematopoietic-stem-cells-and-vessel-formation
#4
REVIEW
Roberto Tamma, Domenico Ribatti
Bone marrow (BM) is a source of hematopoietic stem cells (HSCs). HSCs are localized in both the endosteum, in the so-called endosteal niche, and close to thin-walled and fenestrated sinusoidal vessel in the center of BM, in the so-called vascular niche. HSCs give rise to all types of mature blood cells through a process finely controlled by numerous signals emerging from the bone marrow niches where HSCs reside. This review will focus on the description of the role of BM niches in the control of the fate of HSCs and will also highlight the role of the BM niches in the regulation of vasculogenesis and angiogenesis...
January 13, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28063049/isolation-and-flow-cytometry-analysis-of-innate-lymphoid-cells-from-the-intestinal-lamina-propria
#5
Konrad Gronke, Michael Kofoed-Nielsen, Andreas Diefenbach
The intestinal mucosa constitutes the biggest surface area of the body. It is constantly challenged by bacteria, commensal and pathogenic, protozoa, and food-derived irritants. In order to maintain homeostasis, a complex network of signaling circuits has evolved that includes contributions of immune cells. In recent years a subset of lymphocytes, which belong to the innate immune system, has caught particular attention. These so-called innate lymphoid cells (ILC) reside within the lamina propria of the small and large intestines and rapidly respond to environmental challenges...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28060282/isolation-of-giant-lampbrush-chromosomes-from-living-oocytes-of-frogs-and-salamanders
#6
Joseph G Gall, Zehra F Nizami
We describe methods for studying the giant transcriptionally active lampbrush chromosomes (LBCs) found in the oocyte, or unlaid egg, of frogs and salamanders. Individual LBCs can be up to 1 mm in length and they reside in a gigantic nucleus, itself up to 0.5 mm in diameter. The large size of the chromosomes permits unparalleled observations of active genes by light optical microscopy, but at the same time special techniques are required for isolating the nucleus, removing the nuclear envelope, and spreading the chromosomes on a microscope slide...
December 5, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28045741/is-your-graduating-general-surgery-resident-qualified-to-take-trauma-call-a-15-year-appraisal-of-the-changes-in-general-surgery-education-for-trauma
#7
Aaron Strumwasser, Daniel Grabo, Kenji Inaba, Kazuhide Matsushima, Damon Clark, Elizabeth Benjamin, Lydia Lam, Demetrios Demetriades
BACKGROUND: Trauma training in general surgery residency is undergoing an evolution. Hour restrictions, the growth of subspecialty care and the trend towards non-operative management have altered resident exposure to operative trauma. We sought to identify trends in resident trauma training since the inception of the 80-hour workweek. METHODS: The Accreditation Council for General Medical Education (ACGME) Case Log Statistical Reports for Surgery was abstracted for general surgery resident trauma operative volume for the years 1999-2014...
December 31, 2016: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28043552/role-of-socio-demographical-factors-on-tuberculosis-outcome-in-yemen
#8
Ammar Ali Saleh Jaber, Amer Hayat Khan, Syed Azhar Syed Sulaiman, Nafees Ahmad
OBJECTIVES: Tuberculosis (TB) is an infection disease caused by an organism called Mycobacterium tuberculosis (tubercle bacilli). Tuberculosis remains the most common infection worldwide (Organization & World Health Organization, 2013). Yemen situated in WHO Eastern Mediterranean Region and ranked as intermediate TB-burdened countries. TB considers as one of the main health problems; it ranks as the fourth in the priority of the public health issue (NTCP, 2010). The study was conducted to evaluate the Socio-Demographical variables on tuberculosis treatment outcome...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28035931/psychotropic-polypharmacy-in-patients-with%C3%A2-dementia-prevalence-and-predictors
#9
Ane Nørgaard, Christina Jensen-Dahm, Christiane Gasse, Elsebet Steno Hansen, Gunhild Waldemar
BACKGROUND: Antipsychotics and other psychotropics are frequently used to treat neuropsychiatric symptoms in patients with dementia, even though the evidence for effect is limited. Concerns have been raised about the safety of antipsychotics, but concomitant use of multiple psychotropic drug classes (psychotropic polypharmacy) may also pose a risk for patients. OBJECTIVE: To investigate the prevalence and predictors associated with use of psychotropic polypharmacy in patients with dementia...
December 30, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28027164/meeting-the-needs-for-radiation-protection-diagnostic-imaging
#10
Donald P Frush
Radiation and potential risk during medical imaging is one of the foremost issues for the imaging community. Because of this, there are growing demands for accountability, including appropriate use of ionizing radiation in diagnostic and image-guided procedures. Factors contributing to this include increasing use of medical imaging; increased scrutiny (from awareness to alarm) by patients/caregivers and the public over radiation risk; and mounting calls for accountability from regulatory, accrediting, healthcare coverage (e...
February 2017: Health Physics
https://www.readbyqxmd.com/read/28024184/serpinb9-is-a-marker-of-antigen-cross-presenting-dendritic-cells
#11
M S Mangan, J Vega-Ramos, L T Joeckel, A J Mitchell, A Rizzitelli, B Roediger, D Kaiserman, W W Weninger, J A Villadangos, P I Bird
Serpinb9 (Sb9, also called Spi6) is an intracellular inhibitor of granzyme B (grB) that protects cytotoxic lymphocytes from grB-mediated death. In addition, Sb9 is also expressed in accessory immune cells, including dendritic cells (DCs), although its role is debated. Recently, we have demonstrated that Sb9 plays a grB-independent role in cross-presentation of antigens by CD8(+) DCs. Here, using a mouse line expressing green fluorescent protein knocked in under the control of the Sb9 promoter, we demonstrate that Sb9 expression is highest in those tissue-resident and migratory DC subsets capable of cross-presentation...
December 23, 2016: Molecular Immunology
https://www.readbyqxmd.com/read/28018556/what-is-known-examining-the-empirical-literature-in-resident-work-hours-using-30-influential-articles
#12
Ingrid Philibert
BACKGROUND : Examining influential, highly cited articles can show the advancement of knowledge about the effect of resident physicians' long work hours, as well as the benefits and drawbacks of work hour limits. OBJECTIVE : A narrative review of 30 articles, selected for their contribution to the literature, explored outcomes of interest in the research on work hours-including patient safety, learning, and resident well-being. METHODS : Articles were selected from a comprehensive review...
December 2016: Journal of Graduate Medical Education
https://www.readbyqxmd.com/read/28012843/validation-of-a-novel-cognitive-simulator-for-orbital-floor-reconstruction
#13
Renata Khelemsky, Brianna Hill, Daniel Buchbinder
PURPOSE: The increasing focus on patient safety in current medical practice has promoted the development of surgical simulation technology in the form of virtual reality (VR) training designed largely to improve technical skills and less so for nontechnical aspects of surgery such as decision making and material knowledge. The present study investigated the validity of a novel cognitive VR simulator called Touch Surgery for a core maxillofacial surgical procedure: orbital floor reconstruction (OFR)...
December 11, 2016: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28006736/exploitation-of-rapid-acidification-phenomena-of-food-waste-in-reducing-the-hydraulic-retention-time-hrt-of-high-rate-anaerobic-digester-without-conceding-on-biogas-yield
#14
Kranti Kuruti, Sameena Begum, Shruti Ahuja, Gangagni Rao Anupoju, Sudharshan Juntupally, Bharath Gandu, Devender Kumar Ahuja
The aim of the present work was to study and infer a full scale experience on co-digestion of 1000kg of FW (400kg cooked food waste and 600kg uncooked food waste) and 2000L of rice gruel (RG) on daily basis based on a high rate biomethanation technology called "Anaerobic gas lift reactor" (AGR). The pH of raw substrate was low (5.2-5.5) that resulted in rapid acidification phenomena with in 12h in the feed preparation tank that facilitated to obtain a lower hydraulic residence time (HRT) of 10days. At full load, AGR was fed with 245kg of total solids, 205kg of volatile solids (167kg of organic matter in terms of chemical oxygen demand) which resulted in the generation of biogas and bio manure of 140m(3)/day and 110kg/day respectively...
December 5, 2016: Bioresource Technology
https://www.readbyqxmd.com/read/28003805/glioblastoma-stem-like-cells-characteristics-microenvironment-and-therapy
#15
REVIEW
Yang Yi, I-Yun Hsieh, Xiaojia Huang, Jie Li, Wei Zhao
Glioblastoma multiforme (GBM), grade IV astrocytoma, is the most fatal malignant primary brain tumor. GBM contains functional subsets of cells called glioblastoma stem-like cells (GSCs), which are radioresistant and chemoresistant and eventually lead to tumor recurrence. Recent studies showed that GSCs reside in particular tumor niches that are necessary to support their behavior. To successfully eradicate GBM growth and recurrence, new strategies selectively targeting GSCs and/or their microenvironmental niche should be designed...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27969561/development-of-a-night-float-call-model-for-obstetrics-and-gynaecology-residency-the-process-and-residents-perceptions
#16
Lynn Sterling, Carmen McCaffrey, Michael Secter, Rebecca Rich, Jessica Green, Lindsay Shirreff, Donna Steele
The 2013 pan-Canadian consensus Report on Resident Duty Hours identified that traditional 24-hour duty periods pose risks to the well-being of residents and should be avoided. In anticipation of duty-hour restrictions, the Obstetrics and Gynaecology Residency Program at the University of Toronto developed and implemented a night float (NF) call model over a three-year span. Quarterly resident surveys have consistently shown that the NF system is preferred to traditional 24-hour call and has resulted in reduced fatigue and improved continuity of patient care...
November 2016: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/27968916/intention-to-have-a-second-child-among-chinese-women-one-year-after-the-implementation-of-selective-two-child-policy-a-cross-sectional-survey
#17
Xianglong Xu, Hanxiao Zuo, Yunshuang Rao, Lei Zhang, Lian Lian Wang, Yong Zhao
BACKGROUND: The so-called selective two-child policy was introduced on December, 27, 2015 in China to allow Chinese couples nationwide to have up to two children if either parent is an only child. This study aims to explore Chinese women's intention to have a second child. METHODS: We surveyed women from 16 hospitals in five Chinese provinces from June 1 to August 31, 2015. Multivariable logistic regression analysis was used to evaluate the sociodemographic factors related to seven key reasons for entering second pregnancy...
October 2016: Lancet
https://www.readbyqxmd.com/read/27966637/particles-from-the-echinococcus-granulosus-laminated-layer-inhibit-il-4-and-growth-factor-driven-akt-phosphorylation-and-proliferative-responses-in-macrophages
#18
Paula I Seoane, Dominik Rückerl, Cecilia Casaravilla, Anabella A Barrios, Álvaro Pittini, Andrew S MacDonald, Judith E Allen, Alvaro Díaz
Proliferation of macrophages is a hallmark of inflammation in many type 2 settings including helminth infections. The cellular expansion is driven by the type 2 cytokine interleukin-4 (IL-4), as well as by M-CSF, which also controls homeostatic levels of tissue resident macrophages. Cystic echinococcosis, caused by the tissue-dwelling larval stage of the cestode Echinococcus granulosus, is characterised by normally subdued local inflammation. Infiltrating host cells make contact only with the acellular protective coat of the parasite, called laminated layer, particles of which can be ingested by phagocytic cells...
December 14, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27965570/combining-exergame-training-with-omega-3-fatty-acid-supplementation-protocol-for-a-randomized-controlled-study-assessing-the-effect-on-neuronal-structure-function-in-the-elderly-brain
#19
Alexandra Schättin, Eling D de Bruin
A common problem in the older population is the risk of falling and related injury, immobility, and reduced survival. Age-related neuronal changes, e.g., decline in gray-and white-matter, affect neuronal, cognitive, and motor functioning. The improvement of these factors might decrease fall events in elderly. Studies showed that administration of video game-based physical exercise, a so-called exergame, or omega-3 fatty acid (FA) may improve motor and/or cognitive functioning through neuronal changes in the brain of older adults...
2016: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/27957410/community-to-clinic-navigation-to-improve-diabetes-outcomes
#20
Nancy E Schoenberg, Gabriele Ciciurkaite, Mary Kate Greenwood
Rural residents experience rates of Type 2 Diabetes Mellitus (T2DM) that are considerably higher than their urban or suburban counterparts. Two primary modifiable factors, self-management and formal clinical management, have potential to greatly improve diabetes outcomes. "Community to Clinic Navigation to Improve Diabetes Outcomes," is the first known randomized clinical trial pilot study to test a hybrid model of diabetes self-management education plus clinical navigation among rural residents with T2DM. Forty-one adults with T2DM were recruited from two federally qualified health centers in rural Appalachia from November 2014-January 2015...
March 2017: Preventive Medicine Reports
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