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https://www.readbyqxmd.com/read/27187839/osteosarcoma-after-hematopoietic-stem-cell-transplantation-in-children-and-adolescents-case-report-and-review-of-the-literature
#1
Rejin Kebudi, Harzem Ozger, Hande Kızılocak, Sema Buyukkapu Bay, Bilge Bilgiç
Osteosarcoma as a secondary malignancy after hematopoietic stem cell transplantation (HSCT) is very rare. We present a case and review of 18 other cases reported to date. Our patient underwent HSCT for myelodysplastic syndrome at the age of 4 years. She developed osteosarcoma 13 years later. She underwent surgery after three courses of neoadjuvant chemotherapy followed by chemotherapy and mifamurtide. She has no evidence of disease 28 months after termination of chemotherapy. In 18 other cases of secondary osteosarcoma in the literature, 15 had received total body irradiation, eight had received alkylating agents, and six had received etoposide...
September 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/26346042/outcome-of-autologous-hematopoietic-stem-cell-transplantation-in-children-and-adolescents-with-relapsed-or-refractory-hodgkin-s-lymphoma
#2
Volkan Hazar, Vural Kesik, Serap Aksoylar, Musa Karakukcu, Gulyuz Ozturk, Alphan Kupesiz, Erman Atas, Haldun Oniz, Savas Kansoy, Ekrem Unal, Atila Tanyeli, Fatih Erbey, Murat Elli, Nurdan Tacyildiz, Gulsun Tezcan Karasu, Ulker Kocak, Sema Anak, Sebnem Yilmaz Bengoa, Gulay Sezgin, Didem Atay, Emel Unal, Vedat Uygun, Nilgun Kurucu, Zuhre Kaya, Akif Yesilipek
This study evaluates the outcome of 66 pediatric patients with rrHL who underwent autoHSCT. Twenty-nine patients experienced early relapse, and 19 patients experienced late relapse. Of 18 newly diagnosed with HL, 13 were primary refractory disease and five had late responsive disease. At the time of transplantation, only 68% of the patients were chemosensitive. The majority of patients received BCNU + etoposide + ara-C + melphalan for conditioning (45/66), and peripheral blood (56/66) was used as a source of stem cells...
November 2015: Pediatric Transplantation
https://www.readbyqxmd.com/read/26225646/evaluation-of-inflammation-parameters-in-philadelphia-negative-chronic-myeloproliferative-neoplasia-patients
#3
COMPARATIVE STUDY
Tuba Hacibekiroglu, Sema Akinci, Abdulkadir Basturk, Besime inal, Tekin Guney, Sule Mine Bakanay, Imdat Dilek
BACKGROUND: Chronic myeloproliferative diseases are clonal stem cell diseases which occur as a result of uncontrollable growth and reproduction of hematopoietic stem cells, which are the myeloid series source in bone marrow. Recent studies have suggested that chronic inflammation can be a triggering factor in the clonal change in chronic myeloproliferative neoplasia (CMPN). In our study, we evaluated the existence of a chronic inflammation process in our Philadelphia negative (Ph-)CMPN patients using inflammation parameters in combination with demographic, laboratory and clinical characteristics of the patients...
2015: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/25325708/comparison-of-mesenchymal-stem-cells-isolated-from-pulp-and-periodontal-ligament
#4
COMPARATIVE STUDY
Sema S Hakki, Seyit Ali Kayis, Erdogan E Hakki, S Buket Bozkurt, Gokhan Duruksu, Zehra Seda Unal, Gizem Turaç, Erdal Karaoz
BACKGROUND: Cell-based therapy using mesenchymal stem cells (MSCs) seems promising to obtain regeneration of dental tissues. A comparison of tissue sources, including periodontal ligament (PDL) versus pulp (P), could provide critical information to select an appropriate MSC population for designing predictable regenerative therapies. The purpose of this study is to compare the proliferation and stemness and the MSC-specific and mineralized tissue-specific gene expression of P-MSCs and PDL-MSCs...
February 2015: Journal of Periodontology
https://www.readbyqxmd.com/read/25066893/successful-haematopoietic-stem-cell-transplantation-in-44-children-from-healthy-siblings-conceived-after-preimplantation-hla-matching
#5
Semra Kahraman, Cagri Beyazyurek, Mehmet Akif Yesilipek, Gulyuz Ozturk, Mehmet Ertem, Sema Anak, Savas Kansoy, Serap Aksoylar, Barış Kuşkonmaz, Haldun Oniz, Shimon Slavin, Zeynep Karakas, Huseyin Avni Tac, Nese Gulum, Gokhan Cumhur Ekmekci
Haematopoietic stem cell transplantation (HSCT) remains the best therapeutic option for many acquired and inherited paediatric haematological disorders. Unfortunately, the probability of finding an HLA matched donor is limited. An alternative technique is PGD combined with HLA matching, which offers the possibility of selecting unaffected embryos that are HLA compatible with the sick child, with the aim of possible use of stem cells from the resulting baby in future. Since the first successful report for Fanconi anaemia a decade ago, the therapeutic success of this technique was reported in a few cases and for a limited number of disorders...
September 2014: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/23853066/bone-morphogenetic-protein-2-6-and-7-differently-regulate-osteogenic-differentiation-of-human-periodontal-ligament-stem-cells
#6
Sema S Hakki, Buket Bozkurt, Erdogan E Hakki, Seyit Ali Kayis, Gizem Turac, Irem Yilmaz, Erdal Karaoz
The utility of adult stem cells for bone regeneration may be an attractive alternative in the treatment of extensive injury, congenital malformations, or diseases causing large bone defects. To create an environment that is supportive of bone formation, signals from molecules such as the bone morphogenetic proteins (BMPs) are required to engineer fully viable and functional bone. We therefore determined whether BMP-2, -6, and -7 differentially regulate the (1) proliferation, (2) mineralization, and (3) mRNA expression of bone/mineralized tissue associated genes of human periodontal ligament stem cells (hPDLSCs), which were obtained from periodontal ligament tissue of human impacted third molars...
January 2014: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/23595275/insufficient-opc-migration-into-demyelinated-lesions-is-a-cause-of-poor-remyelination-in-ms-and-mouse-models
#7
Amanda Boyd, Hui Zhang, Anna Williams
Failure of remyelination of multiple sclerosis (MS) lesions contributes to neurodegeneration that correlates with chronic disability in patients. Currently, there are no available treatments to reduce neurodegeneration, but one therapeutic approach to fill this unmet need is to promote remyelination. As many demyelinated MS lesions contain plentiful oligodendrocyte precursor cells (OPCs), but no mature myelinating oligodendrocytes, research has previously concentrated on promoting OPC maturation. However, some MS lesions contain few OPCs, and therefore, remyelination failure may also be secondary to OPC recruitment failure...
June 2013: Acta Neuropathologica
https://www.readbyqxmd.com/read/22931438/hla-matched-family-hematopoetic-stem-cell-transplantation-in-children-with-beta-thalassemia-major-the-experience-of-the-turkish-pediatric-bone-marrow-transplantation-group
#8
M Akif Yesilipek, Mehmet Ertem, Mualla Cetin, Haldun Öniz, Savas Kansoy, Atila Tanyeli, Sema Anak, Emin Kurekci, Volkan Hazar
From January 1991 to June 2009, 245 children with beta thalassemia major who underwent their first allogeneic HSCT in Turkey and who were followed for a minimum of one yr post-transplantation were enrolled this study. The median age of the patients was 6.6 yr old (range, 1-22 yr). The distribution of Pesaro risk class I, II, and III categories was 41, 130, and 63 children, respectively. The median serum ferritin level was 2203 ng/mL. Eighty-eight patients received bone marrow (BM) stem cells; 137, peripheral blood (PB) stem cells; and 20, cord blood (CB) stem cells...
December 2012: Pediatric Transplantation
https://www.readbyqxmd.com/read/22810359/mesenchymal-stem-cell-does-it-work-in-an-experimental-model-with-acute-respiratory-distress-syndrome
#9
Sema Yilmaz, Nihal Inandiklioglu, Dincer Yildizdas, Cansu Subasi, Arbil Acikalin, Yurdun Kuyucu, Ibrahim Bayram, Ali Topak, Atila Tanyeli, Gokhan Duruksu, Erdal Karaoz
We hypothesized that bone marrow-derived mesenchymal stem cells (BM-MSCs) would have a possible role in the treatment of acute respiratory distress syndrome (ARDS). ARDS disease model was developed in Wistar albino male rats by intratracheal instillation of physiological saline solution. Anesthezied and tracheotomized rats (n = 8) with ARDS were pressure-controlled ventilated. Isolated and characterized rat (r-) BM-MSCs were labeled with GFP gene, and introduced in the lungs of the ARDS rat-model. After applying of MSCs, the life span of each rat was recorded...
February 2013: Stem Cell Reviews
https://www.readbyqxmd.com/read/22606205/human-muscle-progenitor-cells-displayed-immunosuppressive-effect-through-galectin-1-and-semaphorin-3a
#10
Séverine Lecourt, Yves Lepelletier, Valérie Vanneaux, Rafika Jarray, Thomas Domet, Françoise Raynaud, Réda Hadj-Slimane, Audrey Cras, Olivier Hermine, Jean-Pierre Marolleau, Jérôme Larghero
In human skeletal muscle, myoblasts represent the main population of myogenic progenitors. We previously showed that, beside their myogenic differentiation capacities, myoblasts also differentiate towards osteogenic and chondrogenic lineages, some properties generally considered being hallmarks of mesenchymal stem cells (MSCs). MSCs are also characterized by their immunosuppressive potential, through cell-cell contacts and soluble factors, including prostaglandin E-2 (PGE-2), transforming growth factor-β1 (TGF-β1), interleukine-10, or indoleamine 2,3-dioxygenase...
2012: Stem Cells International
https://www.readbyqxmd.com/read/22178591/pancreas-specific-deletion-of-prox1-affects-development-and-disrupts-homeostasis-of-the-exocrine-pancreas
#11
Joby J Westmoreland, Gamze Kilic, Caroline Sartain, Sema Sirma, Jennifer Blain, Jerold Rehg, Natasha Harvey, Beatriz Sosa-Pineda
BACKGROUND & AIMS: The exocrine portion of the pancreas functions in digestion and preserves pancreatic homeostasis. Learning how this tissue forms during embryogenesis could improve our understanding of human pancreatic diseases. Expression of the homeobox gene Prox1 in the exocrine pancreas changes throughout development in mice. We investigated the role of Prox1 in development of the exocrine pancreas in mice. METHODS: Mice with pancreas-specific deletion of Prox1 (Prox1(ΔPanc)) were generated and their pancreatic tissues were analyzed using immunohistochemistry, transmission electron microscopy, histologic techniques, quantitative real-time polymerase chain reaction, immunoblotting, and morphometric analysis...
April 2012: Gastroenterology
https://www.readbyqxmd.com/read/20721606/dose-dependent-effect-of-c-type-natriuretic-peptide-signaling-in-glycosaminoglycan-synthesis-during-tgf-%C3%AE-1-induced-chondrogenic-differentiation-of-mesenchymal-stem-cells
#12
Berna Tezcan, Sema Serter, Esat Kiter, A Cevik Tufan
Recent investigations credited important roles to C-type natriuretic peptide (CNP) signaling during chondrogenesis. This study investigated the putative role of CNP in transforming growth factor (TGF)-β1 induced in vitro chondrogenic differentiation of mesenchymal stem cells (MSCs) in pellet culture. MSCs were derived from human trabecular bone and were characterized on the basis of their cell surface antigens and adipogenic, osteogenic, and chondrogenic differentiation potential. TGF-β1 induced chondrogenic differentiation and glycosaminoglycan (GAG) synthesis was analyzed on the basis of basic histology, collagen type II, Sox 9 and aggrecan expressions, and Alcian blue staining...
October 2010: Journal of Molecular Histology
https://www.readbyqxmd.com/read/20716043/thrombotic-microangiopathy-in-allogeneic-stem-cell-transplantation-in-childhood
#13
MULTICENTER STUDY
Fatih Erbey, Ibrahim Bayram, Baris Kuskonmaz, Sema Yilmaz, Mualla Cetin, Duygu Uckan, Atila Tanyeli
OBJECTIVES: We define the incidence, risk factors, and mortality rates for the occurrence of thrombotic microangiopathy in 50 children who underwent transplants between January 2006 and June 2008 at 2 Turkish pediatric centers. MATERIALS AND METHODS: The diagnosis of thrombotic microangiopathy was done according to the reports of International Working Group in 2007. RESULTS: Fifty patients (27 male and 23 female; age range, 3 months to 18 years) were included...
September 2010: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/20146398/respiratory-syncytial-virus-infection-outbreak-among-pediatric-patients-with-oncologic-diseases-and-or-bmt
#14
Sema Anak, Didem Atay, Aysegul Unuvar, Mesut Garipardic, Leyla Agaoglu, Gulyuz Ozturk, Zeynep Karakas, Omer Devecioglu
BACKGROUND: Respiratory syncytial virus (RSV) has been reported to cause severe morbidity and mortality among cancer patients receiving chemotherapy with or without autologous/allogeneic hematopoetic stem cell transplantation (HSCT). There have been few reports describing the outcome of RSV infection specifically among pediatric oncology patients. METHODS: Two RSV infection outbreaks developed between February-April 2006 and January-March 2009 in hospitalized pediatric patients for various hemato-oncological diseases + or - HSCT...
March 2010: Pediatric Pulmonology
https://www.readbyqxmd.com/read/20112369/variable-presence-of-kitd816v-in-clonal-haematological-non-mast-cell-lineage-diseases-associated-with-systemic-mastocytosis-sm-ahnmd
#15
Karl Sotlar, Sema Colak, Anja Bache, Sabina Berezowska, Manuela Krokowski, Burkhard Bültmann, Peter Valent, Hans-Peter Horny
In a substantial number of patients with systemic mastocytosis (SM), an associated clonal haematological non-mast cell lineage disease (AHNMD) is detectable. Although most of these patients display KIT mutations, especially KIT(D816V), little is known about their exact frequency and their distribution in AHNMD subtypes. We examined 48 patients with SM-AHNMD for the presence of mutant KIT in the SM and AHNMD components of the disease. Mast cells and AHNMD cells were obtained from immunostained bone marrow sections by laser microdissection and examined by melting point analysis of nested-PCR products...
April 2010: Journal of Pathology
https://www.readbyqxmd.com/read/20084037/can-serum-cystatin-c-reflect-the-glomerular-filtration-rate-accurately-in-pediatric-patients-under-chemotherapeutic-treatment-a-comparative-study-with-tc-99m-dtpa-two-plasma-sample-method
#16
COMPARATIVE STUDY
Funda Aydin, Gülsün Tezcan, Ozgül Güngör, Arzu Kin Cengiz, Volkan Hazar, Sema Akman, Ayfer Gür Güven, Akif Yeşilipek, Halide Akbaş, Firat Güngör
OBJECTIVE: It was assessed whether cystatin C (cysC) could be used as a marker of glomerular filtration rate (GFR) by considering the technetium-99m diethylenetriamine penta-acetate (Tc-99m DTPA)-two blood sample method (GFRTc-99m DTPA) as the reference in pediatric patients under chemotherapeutic treatment. METHODS: The chemotherapy group (CG) consisted of 31 patients (21 females, 10 males median age: 8.2 years; range: 2-16 years) who had been planned to receive allogenic hematopoietic stem cell transplantation...
April 2010: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/19886821/galectin-1-and-semaphorin-3a-are-two-soluble-factors-conferring-t-cell-immunosuppression-to-bone-marrow-mesenchymal-stem-cell
#17
Yves Lepelletier, Séverine Lecourt, Amédée Renand, Bertrand Arnulf, Valérie Vanneaux, Jean-Paul Fermand, Philippe Menasché, Thomas Domet, Jean-Pierre Marolleau, Olivier Hermine, Jérôme Larghero
In human physiology and animal models, bone marrow mesenchymal stem cells (MSCs) exert an immunosuppressive role in both in vitro and in vivo experiments. However, cellular and molecular mechanisms involved in this process are not clear and remain largely elusive. Several studies have suggested the implication of cell-cell contacts or soluble factors including transforming growth factor-b1 (TGF-b1), interleukin-10 (IL-10), indoleamine 2,3-dioxygenase (IDO), or human leukocyte antigen-G (HLA-G). Here, we show that both Galectin-1 and Semaphorin-3A (Sema-3A), 2 soluble factors capable to inhibit T-cell proliferation through neuropilin-1 (NP-1) binding, are highly expressed by MSCs and may account for their known suppressive activities...
July 2010: Stem Cells and Development
https://www.readbyqxmd.com/read/19353620/renal-function-after-hematopoietic-stem-cell-transplantation-in-children
#18
Volkan Hazar, Ozgul Gungor, Ayfer Gur Guven, Funda Aydin, Halide Akbas, Firat Gungor, Gulsun Tezcan, Sema Akman, Akif Yesilipek
OBJECTIVES: The aim of this study was to assess glomerular and tubular renal function after HSCT in children in a prospective trial. METHODS: Renal function was assessed prospectively before HSCT (on day -10), on days +30, +100, and at least 6 months after transplantation in 34 patients (21 females/13 males) with a mean age of 8.2 years. The following parameters were investigated: glomerular filtration rate (GFR) by creatinine clearance (CrCl), cystatin C (CysC)-based formula and plasma clearance of radiolabeled diethylenetriaminepentaacetic acid ((99m)Tc-DTPA), urinary excretion of beta(2)-microglobulin (beta(2)M), beta-N-acetylglucosaminidase (beta-NAG), fractional excretion of sodium (FE(Na)) and fractional tubular phosphate reabsorption (TP/CrCl)...
August 2009: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/18331539/hematopoietic-stem-cell-transplantation-from-a-donor-with-klinefelter-syndrome-for-wiskott-aldrich-syndrome
#19
Yasemin Isik Balci, Tuba Turul, Ghaniya Daar, Sema Anak, Omer Devecioglu, Ilhan Tezcan, Duygu Uckan Cetinkaya
WAS is a rare X-linked recessive disorder characterized by primary progressive T cell immunodeficiency, impaired antipolysaccharide antibody response, thrombocytopenia with small platelet, and eczematoid dermatitis. Untreated patients with typical WAS have poor prognosis with the major causes of death being infection, bleeding, lymphoproliferative disorders, and malignancy. Due to the increased risk of infectious and hemorrhagic episodes the best results with HSCT are achieved in patients less than five yr of age and are recommended as early as possible...
August 2008: Pediatric Transplantation
https://www.readbyqxmd.com/read/18240317/different-effects-of-mild-and-severe-seizures-on-hippocampal-neurogenesis-in-adult-rats
#20
Fang Yang, Jin-Cun Wang, Jun-Liang Han, Gang Zhao, Wen Jiang
Recent evidence shows that functional neurogenesis exists in the adult hippocampus and that epileptic seizures can increase neurogenesis in the dentate gyrus (DG). However, it is unknown whether different seizure severity has different effects on neurogenesis in the DG of adult rats. In this study, we examined hippocampal neurogenesis in the rat mild and severe seizure preparations characterized with frequent wet dog shakes and severe status epilepticus, respectively. Both mild and severe seizures promoted the mitotic activity in the DG, but severe seizures caused a stronger cell proliferative response than mild seizures...
2008: Hippocampus
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