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Esophagectomy

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https://www.readbyqxmd.com/read/28429196/expression-of-programmed-cell-death-protein-1-by-tumor-infiltrating-lymphocytes-and-tumor-cells-is-associated-with-advanced-tumor-stage-in-patients-with-esophageal-adenocarcinoma
#1
Dagmar Kollmann, Desislava Ignatova, Julia Jedamzik, Yun-Tsan Chang, Gerd Jomrich, Matthias Paireder, Ivan Kristo, Dmitry Kazakov, Michal Michal, Antonio Cozzio, Wolfram Hoetzenecker, Tobias Schatton, Reza Asari, Matthias Preusser, Emmanuella Guenova, Sebastian F Schoppmann
BACKGROUND: Despite recent advances in the therapy for adenocarcinoma of the esophagogastric junction (AEG), overall prognosis remains poor. Programmed cell death protein 1 (PD1) is a co-inhibitory receptor primarily expressed by T-cells. Tumor cells can escape anticancer immune responses by triggering the PD1 pathway. Moreover, PD1 receptor engagement on cancer cells may trigger tumor-intrinsic growth signals. This study aimed to evaluate the potential clinical relevance of PD1 expression by tumor-infiltrating lymphocytes (TILs) and cancer cells in the AEG...
April 20, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28417001/minimally-invasive-esophagectomy-for-esophageal-cancer-according-to%C3%A2-the-location-of-the-tumor-experience-of-251-patients
#2
Lei Chen, Xi Liu, Rong Wang, Yuncang Wang, Tao Zhang, Dewei Gao, Linggen Gao
BACKGROUND: Minimally invasive esophagectomy (MIE) is increasingly used for the treatment of esophageal cancer. However, the ideal approach of MIE is not yet standardized. We explore the ideal approach of MIE according to the location of the tumor and compare the clinical outcomes between patients with cancer arising in the upper third of the esophagus and those with tumors involving the middle and lower third of the esophagus. METHODS: We included patients with esophageal carcinoma and had clear indications for MIE...
May 2017: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/28416335/clinical-outcomes-following-self-expanding-metal-stent-placement-for-esophageal-salvage
#3
Diana H Liang, Eric Hwang, Leonora M Meisenbach, Min P Kim, Edward Y Chan, Puja Gaur Khaitan
OBJECTIVES: To assess the efficacy of self-expanding metal stents (SEMS) for esophageal salvage in patients who would otherwise require esophageal/conduit resection. METHODS: We performed a retrospective chart review of patients who had SEMS placed from January 2010 to December 2015. Patient demographics, esophageal stent characteristics, and outcomes were assessed in our patient cohort. RESULTS: Our study included a total of 83 patients. A total of 148 SEMS were placed, with 121 partially covered SEMS (pcSEMS) and 27 fully covered SEMS (cSEMS)...
March 23, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28412829/egfr-expression-in-patients-with-esophageal-squamous-cell-carcinoma-and-its-association-with-pathologic-response-to-preoperative-chemoradiotherapy-a-study-in-northeastern-iran
#4
Kazem Anvari, Hamid R Sima, Mehdi Seilanian Toussi, Azam Anvari, Soodabeh Shahidsales, Bahram Memar, Seyed Amir Aledavoud, Mohammad N Forghani, Abbas Abdollahi, Kamran Ghaffarzadegan
INTRODUCTION: Esophageal squamous cell carcinoma (ESCC) accounts for 80% of all esophageal cancers worldwide. It is the most common histological type of esophageal carcinoma in low-resource countries. ESCC is prevalent in Asian countries, accounting for more than 95% of esophageal cancers. The epidermal growth factor receptor (EGFR) is involved in cancer development, as its gene is often mutated and/or amplified in cancer cells. According to recent statistics, esophageal cancer is the eighth most common cancer in Iran...
April 2017: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/28410639/socioeconomic-status-not-race-is-associated-with-reduced-survival-in-esophagectomy-patients
#5
Loretta Erhunmwunsee, Brian C Gulack, Christel Rushing, Donna Niedzwiecki, Mark F Berry, Matthew G Hartwig
BACKGROUND: Black patients with esophageal cancer have worse survival than white patients. This study examines this racial disparity in conjunction with socioeconomic status (SES) and explores whether race-based outcome differences exist using a national database. METHODS: The associations between race and SES with overall survival of patients treated with esophagectomy for stages I to III esophageal cancer between 2003 and 2011 in the National Cancer Data Base were investigated using the Kaplan-Meier method and proportional hazards analyses...
April 12, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28404928/preoperative-serum-lipids-as-prognostic-predictors-in-esophageal-squamous-cell-carcinoma-patients-with-esophagectomy
#6
Pengxiang Chen, Lihui Han, Cong Wang, Yibin Jia, Qingxu Song, Jianbo Wang, Shanghui Guan, Bingxu Tan, Bowen Liu, Wenqiao Jia, Jianfeng Cui, Wei Zhou, Yufeng Cheng
This study was to evaluate the prognostic significance of serum lipids in esophageal squamous cell carcinoma patients who underwent esophagectomy. Preoperative serum lipids were collected from 214 patients who were diagnosed with esophageal squamous cell carcinoma. All of the patients received esophagectomy in Qilu Hospital of Shandong University from January 2007 to December 2008. The records and data were analyzed retrospectively. We found that low total cholesterol (for T stage, p = 0.006; for TNM stage, p = 0...
February 23, 2017: Oncotarget
https://www.readbyqxmd.com/read/28404915/prognostic-significance-of-tumor-infiltrating-immune-cells-and-pd-l1-expression-in-esophageal-squamous-cell-carcinoma
#7
Yubo Jiang, Anthony W I Lo, Angela Wong, Wenfeng Chen, Yan Wang, Li Lin, Jianming Xu
Programmed death-1 receptor (PD-1) and its ligand (PD-L1) play an integral role in regulating the immune response against cancer. This study investigated the prognostic significance of PD-L1 expression on tumor cells and tumor-infiltrating immune cells (TILs) in the tumor microenvironment in Chinese patients with esophageal squamous cell carcinoma (ESCC). Archival formalin-fixed, paraffin-embedded ESCC samples from treatment-naïve patients with ESCC after surgery or by diagnostic endoscopic biopsy were collected between 2004 and 2014...
February 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28399060/thoracoscopic-esophagectomy-in-the-prone-position-versus-the-lateral-position-hand-assisted-thoracoscopic-surgery-a-retrospective-cohort-study-of-127-consecutive-esophageal-cancer-patients
#8
Naoya Fukuda, Toshiaki Shichinohe, Yuma Ebihara, Yoshitsugu Nakanishi, Toshimichi Asano, Takehiro Noji, Yo Kurashima, Toru Nakamura, Soichi Murakami, Takahiro Tsuchikawa, Keisuke Okamura, Satoshi Hirano
PURPOSE: To assess the validity of esophagectomy with the patient in the prone position (PP), the short-term surgical results of PP and hand-assisted thoracoscopic surgery (HATS) were compared. METHODS: This study enrolled 127 patients who underwent esophagectomy with HATS (n=91) or PP (n=36) between October 1999 and September 2014. The patients' background characteristics, operative findings, and postoperative complications were examined. RESULTS: The patients' background characteristics were not significantly different...
April 10, 2017: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/28396722/laparoscopic-retrosternal-gastric-pull-up-for-fistulized-mediastinal-mass
#9
Benedetto Mungo, Arianna Barbetta, Anne O Lidor, Miloslawa Stem, Daniela Molena
We describe the case of a patient successfully reconstructed with laparoscopic retrosternal gastric pull-up after esophagectomy for unresectable posterior mediastinal inflammatory myofibroblastic tumor, eroding into the esophagus and compressing the airways. A partial esophagectomy with esophagostomy was performed for treatment of esophageal pleural fistula and empyema, while the airways were managed with the placement of an endobronchial stent. Gastrointestinal reconstruction was performed using a laparoscopic approach to create a retrosternal tunnel for gastric conduit pull-up and cervical anastomosis...
March 27, 2017: World Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28394868/surgeon-age-in-relation-to-prognosis-after-esophageal-cancer-resection
#10
Sheraz R Markar, Hugh Mackenzie, Pernilla Lagergren, Jesper Lagergren
OBJECTIVE: It was hypothesized that patient survival improves with increasing surgeon age up to an age where it then decreases. BACKGROUND: Experience, physical and psychological abilities required for esophagectomy may change with increasing surgeon age. METHODS: This population-based cohort study included all patients having undergone esophagectomy for esophageal cancer in Sweden in 1987 to 2010, with follow-up until 2016. Risk-adjusted cumulative sum (RA-CUSUM) analysis was performed to estimate the relation between surgeon age and 90-day mortality, all-cause, and disease-specific 5-year mortality...
April 7, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28392855/routine-use-of-contrast-swallow-after-total-gastrectomy-and-esophagectomy-is-it-justified
#11
Nader El-Sourani, Helge Bruns, Achim Troja, Hans-Rudolf Raab, Dalibor Antolovic
BACKGROUND: After gastrectomy or esophagectomy, esophagogastrostomy and esophagojejunostomy are commonly used for reconstruction. Water-soluble contrast swallow is often used as a routine screening to exclude anastomotic leakage during the first postoperative week. In this retrospective study, the sensitivity and specificity of oral water-soluble contrast swallow for the detection of anastomotic leakage and its clinical symptoms were analysed. MATERIAL/METHODS: Records of 104 consecutive total gastrectomies and distal esophagectomies were analysed...
2017: Polish Journal of Radiology
https://www.readbyqxmd.com/read/28389050/intestinal-type-gastric-adenocarcinoma-in-a-gastric-tube-reconstructed-after-transhiatal-esophagectomy
#12
H Medina-Franco, L Mejía-Fernández, D Montante-Montes de Oca
No abstract text is available yet for this article.
April 4, 2017: Revista de Gastroenterología de México
https://www.readbyqxmd.com/read/28386749/safety-and-feasibility-of-thoracoscopic-esophagectomy-after-neoadjuvant-chemotherapy-for-esophageal-cancer
#13
Yushi Fujiwara, Shigeru Lee, Satoru Kishida, Ryoya Hashiba, Ken Gyobu, Masashi Takemura, Harushi Osugi
PURPOSE: Neoadjuvant chemotherapy (NAC) with cisplatin and fluorouracil is the recommended standard treatment for resectable locally advanced esophageal cancer (EC) in Japan. We investigated the effects of NAC on the safety and feasibility of thoracoscopic esophagectomy with total mediastinal lymphadenectomy for EC. METHODS: This retrospective study analyzed data from 225 consecutive patients who underwent thoracoscopic esophagectomy with lymph node dissection between April 2007 and December 2015...
April 6, 2017: Surgery Today
https://www.readbyqxmd.com/read/28386210/re-evaluation-of-the-role-of-thoracoscopic-esophagectomy-as-a-japanese-style-radical-surgery
#14
Harushi Udagawa, Masaki Ueno, Shusuke Haruta, Tsuyoshi Tanaka, Aya Mizuno, Yu Ohkura
PURPOSE: To investigate the value of thoracoscopic surgery in radical esophagectomy with three-field lymphadenectomy. MATERIALS AND METHOD: The subjects were 329 consecutive patients who, without preoperative chemoradiotherapy, underwent R0 radical esophagectomy with three-field lymphadenectomy for thoracic squamous cell esophageal cancers during 1998-2013. Open thoracotomy was applied in 212 (O), and thoracoscopic surgery in 117 (V). Survivals according to TNM Stages and Efficacy index (EI) were analyzed...
2017: Esophagus: Official Journal of the Japan Esophageal Society
https://www.readbyqxmd.com/read/28385379/specific-gene-expression-profiles-are-associated-with-a-pathologic-complete-response-to-neoadjuvant-therapy-in-esophageal-adenocarcinoma
#15
Patrick J McLaren, Anthony P Barnes, Willy Z Terrell, Gina M Vaccaro, Jack Wiedrick, John G Hunter, James P Dolan
BACKGROUND: Predicting treatment response to chemo-radiotherapy (CRT) in esophageal cancer remains an unrealized goal despite studies linking constellations of genes to prognosis. We aimed to determine if specific expression profiles are associated with pathologic complete response (pCR) after neoadjuvant CRT. METHODS: Eleven genes previously associated with esophageal cancer prognosis were identified. Esophageal adenocarcinoma (EAC) patients treated with neoadjuvant CRT and esophagectomy were included...
March 27, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28385376/selective-en-masse-ligation-of-the-thoracic%C3%A2-duct-to-prevent-chyle-leak-after%C3%A2-esophagectomy
#16
Yidan Lin, Zhihui Li, Gang Li, Xiaolong Zhang, Hanyu Deng, Xiaoyan Yang, Lunxu Liu
BACKGROUND: Postoperative chylothorax remains an important cause of reoperation and prolonged hospital stay after esophagectomy for the treatment of esophageal carcinoma. Chylothorax is potentially life threatening and difficult to manage. The benefit of routine thoracic duct ligation is controversial. A promising alternative is to identify chyle leaks at the time of esophagectomy and perform the ligation selectively. We developed a novel technique to identify chyle leak at the time of esophagectomy and compared it with routine ligation of thoracic duct...
April 3, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28385375/the-society-of-thoracic-surgeons-composite-score-for-evaluating-esophagectomy-for-esophageal-cancer
#17
(no author information available yet)
BACKGROUND: The Society of Thoracic Surgeons (STS) has developed composite quality measures for cardiac surgical procedures and lobectomy for lung cancer. This study sought to develop a composite measure for esophagectomy for esophageal cancer. METHODS: The STS esophagectomy composite score is derived from two risk-adjusted outcomes: mortality and major complications. General Thoracic Surgery Database data were included from 2012 to 2014, and 95% Bayesian credible intervals were established to determine "star" ratings...
April 3, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28385100/predictive-factors-for-the-migration-of-endoscopic-self-expanding-metal-stents-placed-in-the-foregut
#18
Jordan L Singer, Amir H Aryaie, Mojtaba Fayezizadeh, Jon Lash, Jeffrey M Marks
BACKGROUND: With recent advancements in endoscopy, self-expandable metal stents (SEMS) have been used to treat gastrointestinal leaks, perforations, and strictures. Stent migration frequently complicates management and often requires additional treatments to reach resolution. Our study aimed to determine predictive factors for stent migration. METHODS: Consecutive procedures involving SEMS placed with and without fixation after upper gastrointestinal surgery between 2009 and 2014 were retrospectively reviewed...
April 1, 2017: Surgical Innovation
https://www.readbyqxmd.com/read/28384375/risk-factors-for-anastomotic-leakage-following-esophagectomy-impact-of-thoracic-epidural-analgesia
#19
Wen Wang, Gefei Zhao, Linxin Wu, Yanpeng Dong, Chaobin Zhang, Li Sun
BACKGROUND AND OBJECTIVES: Anastomotic leakage (AL) is one of common complications after esophageal cancer surgery. Thoracic epidural analgesia (TEA) is often recommended in patients undergoing esophagectomy. However, the impact of TEA on AL is still controversial. Thus, we conducted this study to evaluate the effect of TEA on the occurrence of AL and identify risk factors for the development of AL following esophagectomy. METHODS: Our retrospective study identified patients who underwent elective esophagectomy between July 2013 and July 2016...
April 6, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28383428/secondary-aorto-esophageal-fistula-after-esophagectomy-treated-with-endovascular-treatment-a-case-report
#20
Wangang Ren, Yuxiang He, Xiaohang Wang, Zhongmin Peng
RATIONALE: Aorto-esophageal fistula (AEF), a postoperative complication of esophagectomy, constitutes a very small percentage of all cases presenting with AEF; however, it is associated with a high mortality rate. Acute massive hemorrhage is the single largest cause of death in patients developing AEF. There is a lack of consensus on the optimal treatment of AEF. PATIENT CONCERNS: We present 3 cases secondary to esophagectomy due to lower thoracic esophageal carcinoma...
April 2017: Medicine (Baltimore)
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