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Fever and neutropenia

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https://www.readbyqxmd.com/read/29690925/staphylococcus-epidermidis-meningitis-in-the-absence-of-a-neurosurgical-device-secondary-to-catheter-related-bloodstream-infection-a-case-report-and-review-of-the-literature
#1
Taro Noguchi, Miki Nagao, Masaki Yamamoto, Yasufumi Matsumura, Toshiyuki Kitano, Akifumi Takaori-Kondo, Satoshi Ichiyama
BACKGROUND: Staphylococcus epidermidis can cause nosocomial meningitis in the presence of prosthetic devices. We describe a case of Staphylococcus epidermidis meningitis in a patient with neutropenia who had no intracranial foreign body, and we review the literature on meningitis that is caused by coagulase-negative Staphylococcus spp. without a neurosurgical device. CASE PRESENTATION: A 47-year-old Japanese man with acute myeloid leukemia receiving chemotherapy through a totally implantable central venous catheter developed fever and headache...
April 25, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29687743/clinical-outcomes-of-treatment-with-filgrastim-versus-a-filgrastim-biosimilar-and-febrile-neutropenia-associated-costs-among-patients-with-nonmyeloid-cancer-undergoing-chemotherapy
#2
Lee S Schwartzberg, Lincy S Lal, Sanjeev Balu, Kim Campbell, Lee Brekke, Andrew DeLeon, Caitlin Elliott, Stephanie Korrer
BACKGROUND: Granulocyte colony-stimulating factors such as filgrastim are used to decrease the incidence of febrile neutropenia (FN) among patients with nonmyeloid cancers undergoing chemotherapy treatment. Although the biosimilar filgrastim-sndz has been approved in the United States since 2015, limited real-world comparisons of filgrastim-sndz versus reference filgrastim (filgrastim-ref) have been conducted. OBJECTIVE: To compare FN incidence and assess overall FN-related health care resource utilization and medical costs among U...
April 24, 2018: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/29670779/pulmonary-mucormycosis-in-chronic-lymphocytic-leukemia-and-neutropenia
#3
Izza Mir, Sijan Basnet, David Ellsworth, Elan Mohanty
Pulmonary mucormycosis is a rare life-threatening fungal infection associated with high mortality. We present the case of a 61-year-old man with history of chronic lymphocytic leukemia who presented with fever and cough, eventually diagnosed with pulmonary mucormycosis after right lung video-assisted thoracoscopic surgery. The patient was successfully treated with amphotericin B and right lung pneumonectomy; however, he later died from left lung pneumonia.
2018: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/29652973/-febrile-neutropenia-in-cancer-patients-management-in-the-emergency-room
#4
Daniel Rivera-Salgado, Kathia Valverde-Muñoz, María L Ávila-Agüero
Febrile neutropenia is a life-threatening condition that requires immediate attention, especially in patients with chemotherapy-related neutropenia. Patients with febrile neutropenia have a much greater risk of developing bacterial disease, and fever may be the only indicator of severe bacterial infection. Adequate management of febrile neutropenia emphasizes early recognition of patients, risk stratification, and antibiotic therapy administration during the first 60 minutes of admission to an emergency room...
2018: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/29622943/management-and-preventive-measures-for-febrile-neutropenia
#5
Austin J Lucas, Jacqueline L Olin, Megan D Coleman
Febrile neutropenia (FN) is an oncological emergency and serious complication often resulting from chemotherapy. In patients with a weak or completely suppressed immune system, a fever may be the only sign of an underlying infection and immediate treatment is needed. Using risk evaluation scores, it is possible to stratify individual patient degree of risk. However, all patients warrant immediate antibiotic coverage. Antibiotic treatment of FN is broadened or narrowed based on individualized clinical scenarios...
April 2018: P & T: a Peer-reviewed Journal for Formulary Management
https://www.readbyqxmd.com/read/29616457/presepsin-as-a-diagnostic-marker-of-bacterial-infections-in-febrile-neutropenic-pediatric-patients-with-hematological-malignancies
#6
Ahmad Baraka, Marwa Zakaria
Febrile neutropenia (FN) is often observed in hematological malignancies (HEM). Presepsin is also known as soluble CD14 subtype; it is a glycoprotein fragment derived from monocytes and macrophages. We aimed to evaluate the significance of presepsin and other biomarkers for diagnosis of bacteremia in children with HEM. Sixty pediatric patients with different HEM (acute lymphoblastic leukemia 36, acute myeloid leukemia 12, non-Hodgkin lymphoma 10, and Hodgkin disease 2). Thirty age and sex-matched healthy children serving as control were enrolled in this study...
April 3, 2018: International Journal of Hematology
https://www.readbyqxmd.com/read/29608680/extended-versus-bolus-infusion-of-broad-spectrum-%C3%AE-lactams-for-febrile-neutropenia-an-unblinded-randomized-trial
#7
Ron Ram, Yael Halavy, Odelia Amit, Yael Paran, Eugene Katchman, Bruria Yachini, Svetlana Kor, Irit Avivi, Ronen Ben-Ami
Background: Febrile neutropenia may be a sign of severe infection, and is associated with significant morbidity and mortality in high-risk patients with hematologic malignancies. Extended infusion of β-lactam antibiotics is associated with greater clinical response than is bolus infusion in non-neutropenic critically ill patients, but data are lacking for febrile neutropenic patients. Methods: We designed a single-center, non-blinded randomized trial comparing extended infusion (4 hours) and bolus infusion (30 minutes) of piperacillin-tazobactam or ceftazidime in high-risk patients with febrile neutropenia...
March 28, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29607229/a-case-of-levamisole-induced-agranulocytosis
#8
Thamer Kassim, Lakshmi Chintalacheruvu, Osman Bhatty, Mohammad Selim, Osama Diab, Ali Nayfeh, Jayadev Manikkam Umakanthan, Maryam Gbadamosi-Akindele
A sixty-eight-year-old male with a past medical history of recurrent cocaine use presented to the emergency department with recurrent diarrhea and was found to have a white blood cell (WBC) count of 1.9 × 109 /L with agranulocytosis (absolute neutrophil count (ANC) of 95 cell/mm3 ). At admission, the patient disclosed that he used cocaine earlier during the day, and a urine drug screen tested positive for this. On hospital day one, the patient was found to have a fever with a maximum temperature of 313...
2018: Case Reports in Hematology
https://www.readbyqxmd.com/read/29598953/chemoradiotherapy-using-retrograde-superselective-intra-arterial-infusion-for-tongue-cancer-analysis-of-therapeutic-results-in-118-cases
#9
Kenji Mitsudo, Yuichiro Hayashi, Shuhei Minamiyama, Nobuhide Ohashi, Masaki Iida, Toshinori Iwai, Senri Oguri, Toshiyuki Koizumi, Mitomu Kioi, Makoto Hirota, Izumi Koike, Masaharu Hata, Iwai Tohnai
OBJECTIVES: To evaluate the therapeutic results and rate of organ preservation in patients with squamous cell carcinoma of the tongue treated with retrograde superselective intra-arterial chemoradiotherapy. MATERIALS AND METHODS: Between June 2006 and June 2015, 118 patients with tongue cancer were treated with intra-arterial chemoradiotherapy. Treatment consisted of radiotherapy (total 50-70 Gy) and daily concurrent intra-arterial chemotherapy (docetaxel, total 50-70 mg/m2 ; cisplatin, total 125-175 mg/m2 ) for 5-7 weeks...
April 2018: Oral Oncology
https://www.readbyqxmd.com/read/29590407/costs-associated-with-febrile-neutropenia-in-japanese-patients-with-primary-breast-cancer-post-hoc-analysis-of-a-randomized-clinical-trial
#10
Osamu Miyake, Kyoko Murata, Shiro Tanaka, Hiroshi Ishiguro, Masakazu Toi, Kazuo Tamura, Koji Kawakami
Background: Febrile neutropenia (FN), a decrease in blood neutrophils accompanied by fever, is a major adverse event (AE) associated with cancer chemotherapy. We aimed to estimate the direct medical costs associated with FN management in breast cancer patients within a clinical trial with pegfilgrastim, a pegylated form of recombinant granulocyte colony-stimulating factor (G-CSF). Methods: We obtained data from 346 Japanese breast cancer patients in a randomized, placebo-controlled clinical trial comparing FN incidence due to TC adjuvant chemotherapy (docetaxel 75 mg/m2, cyclophosphamide 600 mg/m2) between pegfilgrastim-treated and placebo groups...
March 26, 2018: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29589346/-recommendations-for-diagnostics-and-therapy-of-children-with-cancer-presenting-with-fever-and-neutropenia-comparison-of-two-current-guidelines
#11
Thomas Lehrnbecher, Andreas Groll, Philipp Agyeman, Roland A Ammann, Andishe Attarbaschi, Uta Behrends, Christoph Berger, Axel Hamprecht, Markus Hufnagel, Hans-Jürgen Laws, Max Scheler, Christian Temme, Simon Vieth, Arne Simon
Immunocompromised children and adolescents receiving treatment for cancer have a considerably increased risk for infection. Neutropenia is the most important single risk factor for infectious complications, and fever in neutropenia is considered as an emergency. Whereas guidelines for the management of fever in neutropenic adults have been established for decades, specific pediatric guidelines have not been developed until recently. As children differ in many aspects from adults such as in the underlying malignancy or in the availability and dosing of antimicrobial compounds, guidelines for pediatric patients are important...
March 27, 2018: Klinische Pädiatrie
https://www.readbyqxmd.com/read/29573075/plasmodium-falciparum-infection-transmitted-by-transfusion-a-cause-of-hemophagocytic-syndrome-after-bone-marrow-tranplantation-in-a-non-endemic-country
#12
Saloua Ladeb, Nour Ben Abdejlil, Najla Fakhfakh, Amel Lakhal, Dorra Belloumi, Leila Ben Hamed, Aicha Kallel, Lamia Torjman, Rym El Fatimi, Slama Hmida, Kalthoum Kallel, Tarek Ben Othman
A 27-year-old man with severe aplastic anemia underwent bone marrow transplantation from his HLA identical brother in July 2016. Conditioning included ATGAM 30 mg/kg for 3 days and Cyclophosphamide 50 mg/kg for 4 days. The patient received several platelet and red blood cell transfusions before and after the conditioning. The patient received broad spectrum antibiotics and caspofungin because persistant febrile neutropenia without bacteriological or mycological documentation. Hemophagocytic syndrome was diagnosed on day +12...
March 23, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29564582/novel-mutation-in-cecr1-leads-to-deficiency-of-ada2-with-associated-neutropenia
#13
Funda Erol Cipe, Cigdem Aydogmus, Nina K Serwas, Gonca Keskindemirci, Kaan Boztuğ
PURPOSE: Adenosine deaminase 2 (ADA2) have been reported to cause vasculitic diseases and immunodeficiency recently. Patients present with stroke episodes and rashes mimicking polyarteritis nodosa (PAN). We report a patient who has been followed up with severe neutropenia and found an unexpectedly revealed novel mutation in CECR1 affecting ADA2. METHODS: We reviewed medical records and clinical history of the patient. No mutations in other known neutropenia genes such as ELA, G6PC3, HAX1, AP3B1, LAMTOR2, VPS13B, VPS45, GFI1, JAGN1, or WAS could be detected...
March 21, 2018: Journal of Clinical Immunology
https://www.readbyqxmd.com/read/29556814/a-cohort-study-on-protocol-based-nurse-led-out-patient-management-of-post-chemotherapy-low-risk-febrile-neutropenia
#14
Fiona Lim Mei Ying, Maria Choy Yin Ping, Macy Tong, Elaine Yim Pik Yan, Tracy Lui Siu Yee, Lam Yuk Ting, Anita Lo Wing Sim, Lui Cheuk Yu, Bosco Lam Hoi Shiu, Ashley Cheng Chi Kin
PURPOSE: International guidelines adopt risk stratification approach to manage patients with low-risk febrile neutropenia patients. We developed this out-patient program using shared-care model with professional input and patient empowerment, so as to reduce patients' psychological burden from hospitalization and to improve the cost-effectiveness of management. METHOD: This is a prospective cohort study to compare the efficacy and safeness of the out-patient program when compared with traditional in-patient care...
March 20, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29549060/fluoroquinolone-prophylaxis-during-neutropenia-what-can-we-expect-nowadays
#15
Malgorzata Mikulska, Catherine Cordonnier
Yeshurun et al. reported the results of retrospective study with historical control in patients with multiple myeloma and lymphoma undergoing autologous transplant. The rates of bacteraemia and fever were lower during the period of ciprofloxacin prophylaxis with no effect on mortality. In the era of multidrug resistance (MDR), the efficacy of fluoroquinolone prophylaxis might be lower in settings with high level of resistance. Additionally, the benefit of fluoroquinolone prophylaxis on mortality should not be expected since the morality is mainly associated with infections due to MDR currently associated with MDR strains which could not be prevented by fluoroquinolone prophylaxis...
March 13, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29534335/lupus-erythematosus-cell
#16
Armin Rashidi, Stephen I Fisher
A 24-year-old woman with a history of systemic lupus erythematosus (SLE) presented with fever, polyarthralgia, and worsened neutropenia (0.5 x 109 /L). Her physical exam and other routine laboratory work up were unremarkable. Examination of a peripheral blood smear showed neutrophils (red arrows, A-C) engulfing homogenous, violaceus nuclear material (yellow arrows, A-C), confirming a suspected diagnosis of lupus flare. SLE-associated antinuclear antibodies opsonize nucleoproteins released from dying cells, with uptake by phagocytic cells, including polymorphonuclear leukocytes and macrophages, the so-called Lupus Erythematosus (LE) cells...
March 13, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29534058/pediatric-patients-at-risk-for-fever-in-chemotherapy-induced-neutropenia-in-bern-switzerland-1993-2012
#17
Annina N von Allmen, Maxime G Zermatten, Kurt Leibundgut, Philipp Agyeman, Roland A Ammann
Fever in neutropenia (FN) is the most frequent potentially life threatening complication of chemotherapy for cancer. Prediction of the risk to develop FN during chemotherapy would allow for targeted prophylaxis. This retrospective, single centre cohort study in pediatric patients diagnosed with cancer before 17 years covered two decades, 1993 to 2012. The 583 (73%) of 800 patients diagnosed with cancer who had received chemotherapy were studied here. Data on 2113 observation periods was collected, defined by stable combinations of 11 predefined characteristics potentially associated with FN...
March 13, 2018: Scientific Data
https://www.readbyqxmd.com/read/29532539/co-transplantation-of-haploidentical-hematopoietic-stem-cell-and-allogeneic-bone-marrow-derived-mesenchymal-stromal-cells-as-a-first-line-treatment-in-very-severe-aplastic-anemia-patients-with-refractory-infections
#18
Chunyan Yue, Yingying Ding, Yang Gao, Li Li, Yan Pang, Zenghui Liu, Hang Zhang, Yang Xiao, Zujun Jiang, Haowen Xiao
OBJECTIVES: In patients with very severe aplastic anemia (VSAA), neutropenia is prolonged and persistent, resulting in refractory overwhelming infections. Hematopoiesis recovery is urgently needed. METHODS: Six patients with de novo VSAA lacking HLA-identical sibling donors and those who experienced refractory infections, underwent haploidentical related donor (HRD) hematopoietic stem cell transplantation (HSCT) as a first-line therapy. The conditioning regimen consisted of busulfan, cyclophosphamide and rabbit antithymocyte globulin...
March 12, 2018: European Journal of Haematology
https://www.readbyqxmd.com/read/29531738/febrile-neutropenia-with-bacterial-paronychia
#19
Yuki Hosono, Takeshi Uenami, Yukihiro Yano, Masahide Mori
The symptoms of infection can be minimal or absent in patients with febrile neutropenia at first. The focal site of infection, which may be the main cause of a fever or be a complication of neutropenia, can develop as neutrophils increase during the clinical course of febrile neutropenia.
March 2018: Clinical Case Reports
https://www.readbyqxmd.com/read/29531656/chemotherapy-colchicine-interaction-in-a-child-with-familial-mediterranean-fever-and-hodgkin-lymphoma
#20
Karin P S Langenberg-Ververgaert, Ronald M Laxer, Angela S Punnett, L Lee Dupuis, Yaron Finkelstein, Oussama Abla
Familial Mediterranean fever (FMF) has been associated with hematological malignancies but has not been reported in association with Hodgkin lymphoma (HL). We hereby describe the first pediatric patient with FMF and stage IIA nodular sclerosis HL. She was treated with prednisone, doxorubicin, vincristine and etoposide (OEPA) being on therapy with colchicine. However, she suffered more than expected treatment-related toxicity attributed either to chemotherapy (severe neutropenia) or colchicine (Abdominal pains and diarrhoea)...
2018: Mediterranean Journal of Hematology and Infectious Diseases
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