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https://www.readbyqxmd.com/read/28749128/distribution-characteristics-of-human-papillomavirus-infection-a-study-based-on-data-from-physical-examination
#1
Xiao Hui Zhou, Yan Feng Shi, Li Jie Wang, Mei Liu, Fang Li
Objective: Human papillomavirus (HPV) is the primary cause of cervical cancer. The purpose of this study was to investigate the prevalence and type distribution of HPV DNA positive in women undergoing routine physical examination. Methods: 2,452 women were enrolled between March and November 2013. Participants were tested for 23 HPV types using polymerase chain reaction (PCR) and reverse dot blot hybridization. HPV DNA detection prevalence was estimated in different age groups. Results: Mean age (SD) of study participants was 47...
July 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28749118/prevalence-of-human-papillomavirus-infection-in-breast-cancer-cells-from-thai-women
#2
Jarunya Ngamkham, Anant Karalak, Akrom Chaiwerawattana, Adisak Sornprom, Somchai Thanasutthichai, Saowakorn Sukarayodhin, Maneerut Mus-u-Dee, Krittika Boonmark, Thainsang Phansri, Nattapon Laochan
Breast cancer is the leading female cancer worldwide and is the most frequently diagnosed in Thai women. Its potential etiologic has not been clearly identified. Several recent reports could detect human papillomavirus (HPV) infection in breast cancer or benign breast lesions. HPV infection considered suggests being one of many risk factors for cancer development. The aim of this study was to determine the frequency of HPV infection in both breast cancer and benign breast lesion/tumor tissues. Seven hundred samples from Thai women were collected during 2013-2015 and statistically correlation between HPV infection, sociodemographic and histopathological parameters were also analyzed...
July 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28749044/video-assisted-thoracoscopic-lobectomy-after-percutaneous-coronary-intervention-in-lung-cancer-patients-with-concomitant-coronary-heart-disease
#3
Xin Li, YiLi Fu, JinBai Miao, Hui Li, Bin Hu
BACKGROUND: In recent years, based on clinical observations, the number of lung cancer patients with concomitant coronary heart disease (CHD) has gradually increased. However, because of the requirement of long-term anticoagulant therapy after percutaneous coronary intervention (PCI), some of these patients lose the opportunity for surgical treatment, resulting in tumor progression. The objective of this study was to determine the appropriate timing of video-assisted thoracic surgery (VATS) lobectomy after PCI without increasing perioperative cardiovascular risk...
July 27, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28748356/pd-l1-induced-by-ifn-%C3%AE-from-tumor-associated-macrophages-via-the-jak-stat3-and-pi3k-akt-signaling-pathways-promoted-progression-of-lung-cancer
#4
Xiaohui Zhang, Yuanyuan Zeng, Qiuxia Qu, Jianjie Zhu, Zeyi Liu, Weiwei Ning, Hui Zeng, Nan Zhang, Wenwen Du, Cheng Chen, Jian-An Huang
BACKGROUND: Interferon-γ (IFN-γ) is conventionally regarded as an inflammatory cytokine that has a pivotal role in anti-infection and tumor immune surveillance. It has been used clinically to treat a variety of malignancies. However, increased evidence has suggested IFN-γ can act to induce tumor progression. The role of IFN-γ in regulating antitumor immunity appears to be complex and paradoxical. The mechanism underlying the dual aspects of IFN-γ function in antitumor immunity is not clear...
July 26, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28748033/candida-and-porphyromonas-gingivalis-the-effect-on-wound-closure-in-vitro
#5
Thijs M Haverman, Alexa M G A Laheij, Johannes J de Soet, Jan de Lange, Frederik R Rozema
Microorganisms play a role in oral mucositis after cancer therapy. The current study explored the hypothesis that Candida spp. alone and together with Porphyromonas gingivalis cause delayed healing of oral ulcerations due to the inhibition of wound closure. An in vitro scratch assay model was used to study the influence of viable and heat-killed Candida glabrata, Candida kefyr, and Candida albicans on cell migration of oral epithelial cells. Separately, the effect of conditioned medium of Candida spp. and the effect of a mixed infection of Candida spp...
2017: Journal of Oral Microbiology
https://www.readbyqxmd.com/read/28747910/natural-killer-cell-based-cancer-immunotherapies-from-immune-evasion-to-promising-targeted-cellular-therapies
#6
Erhard Hofer, Ulrike Koehl
Immunotherapies based on natural killer (NK) cells are among the most promising therapies under development for the treatment of so far incurable forms of leukemia and other types of cancer. The importance of NK cells for the control of viral infections and cancer is supported among others by the findings that viruses and tumors use a multitude of mechanisms to subvert and evade the NK cell system. Infections and malignant diseases can further lead to the shaping of NK cell populations with altered reactivity...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28747501/mhv68-expressing-kshv-lana-reveals-both-functional-conservation-and-divergence-in-lana-homologs
#7
Arundhati Gupta, Darby G Oldenburg, Eduardo Salinas, Douglas W White, J Craig Forrest
Latency-associated nuclear antigen (LANA) is a multifunctional protein encoded by members of the Rhadinovirus genus of gammaherpesviruses. Studies using murine gammaherpesvirus 68 (MHV68) demonstrated that LANA is important for acute replication, latency establishment, and reactivation in vivo Despite structural similarities in their DNA-binding domains (DBDs), LANA homologs from Kaposi sarcoma-associated herpesvirus (KSHV) and MHV68 exhibit considerable sequence divergence. We sought to determine if KSHV and MHV68 LANA homologs are functionally interchangeable...
July 26, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28746988/the-association-between-clinical-outcome-and-cd8-lymphocytic-infiltration-in-advanced-stages-of-colorectal-cancer-differs-by-latent-virus-infection-in-the-tumour-tissue
#8
Britta Kleist, Marius Bagdonas, Prakash Oommen, Irina Schoenhardt, Janina Levermann, Micaela Poetsch
AIMS: In near future, an immunoscore based on the quantification of lymphocytic populations can be expected as fundamental supplement of colorectal cancer (CRC) classification. This study explored, whether latent viral infection has an influence on prognostic relevant host immunity in CRC. METHODS AND RESULTS: CD8+ lymphocytic infiltration in three tumour compartments of 121 CRC was compared with clinical data and occurrence of latent infection with HSV1, HSV2, CMV, EBV, HPV16, and HPV18 in the tumour tissue, which was determined by PCR...
July 26, 2017: Histopathology
https://www.readbyqxmd.com/read/28746835/genetic-ataxia-telangiectasia-porcine-model-phenocopies-the-multisystemic-features-of-the-human-disease
#9
Rosanna Beraldi, David K Meyerholz, Alexei Savinov, Attila D Kovács, Jill M Weimer, Jordan A Dykstra, Ryan D Geraets, David A Pearce
Ataxia telangiectasia (AT) is a progressive multisystem autosomal recessive disorder caused by mutations in the AT-mutated (ATM) gene. Early onset AT in children is characterized by cerebellar degeneration, leading to motor impairment. Lung disease and cancer are the two most common causes of death in AT patients. Accelerated thymic involution may contribute to the cancer, and recurrent and/or chronic respiratory infections may be a contributing factor to lung disease in AT. AT patients have fertility issues, are highly sensitive to ionizing radiation and they present oculocutaneous telangiectasia...
July 23, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28746217/18f-fluoro-deoxy-glucose-positron-emission-tomography-combined-with-computed-tomography-can-reliably-rule-out-infection-and-cancer-in-patients-with-anti-neutrophil-cytoplasmic-antibody-associated-vasculitis-suspected-of-disease-relapse
#10
Evan C Frary, Søren Hess, Oke Gerke, Helle Laustrup
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a group of autoimmune diseases characterized by systemic inflammation in small- to medium-sized blood vessels. Although immunosuppressive therapy has greatly improved the prognosis for these patients, there are still significant comorbidities, such as cancer and infection, associated with AAV. These comorbidities are often indistinguishable from an underlying AAV disease relapse, and create a clinical conundrum, as these conditions are normally contraindications for immunosuppressive treatment...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28746085/impact-of-screening-and-antiretroviral-therapy-on-anal-cancer-incidence-in-hiv-positive-msm
#11
Nello Blaser, Barbara Bertisch, Roger D Kouyos, Alexandra Calmy, Heiner C Bucher, Matthias Cavassini, Janne Estill, Olivia Keiser, Matthias Egger
BACKGROUND: The incidence of anal cancer is high in HIV-positive MSM. We modeled the impact of screening strategies and combination antiretroviral therapy (cART) coverage on anal cancer incidence in Switzerland. METHODS: Individual-based, dynamic simulation model parameterized with Swiss HIV Cohort Study and literature data. We assumed all men to be human papillomavirus infected. CD4 cell count trajectories were the main predictors of anal cancer. From 2016 we modeled cART coverage either as below 100% (corresponding to 2010-2015) or as 100%, and the following four screening strategies: no screening, yearly anal cytology (Papanicolaou smears), yearly anoscopy and targeted anoscopy 5 years after CD4 count dropped below 200 cells/μl...
August 24, 2017: AIDS
https://www.readbyqxmd.com/read/28745795/research-on-the-mechanism-of-hp-mediated-pi3k-akt-gsk3%C3%AE-pathways-in-gastric-cancer
#12
W Geng, H-Y Zhang
OBJECTIVE: This study aimed to investigate the mechanism of Helicobacter pylori (HP) mediated PI3K/AKT/GSK3β signal pathways in the occurrence of gastric cancer. PATIENTS AND METHODS: For this purpose, a total of 90 patients were selected; 30 were suffering from gastric cancer and gastric ulcer (observation group I), 30 were suffering from pure gastric ulcer (observation group II) and 30 were with chronic gastritis (control group), and the lesion tissues were extracted by using endoscopy...
July 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28744797/reconstructing-the-immune-system-with-lentiviral-vectors
#13
REVIEW
Henning Olbrich, Constanze Slabik, Renata Stripecke
Lentiviral vectors (LVs) developed in the past two decades for research and pre-clinical purposes have entered clinical trials with remarkable safety and efficacy performances. Development and clinical testing of LVs for improvement of human immunity showed major advantages in comparison to other viral vector systems. Robust and persisted transduction efficiency of blood cells with LVs, resulted into a broad range of target cells for immune therapeutic approaches: from hematopoietic stem cells and precursor cells for correction of immune deficiencies, up to effector lymphoid and myeloid cells...
July 25, 2017: Virus Genes
https://www.readbyqxmd.com/read/28744744/the-effect-of-neoadjuvant-chemoradiation-on-anastomotic-leak-and-additional-30-day-morbidity-and-mortality-in-patients-undergoing-total-gastrectomy-for-gastric-cancer
#14
Ivy N Haskins, Matthew D Kroh, Richard L Amdur, Jeffrey L Ponksy, John H Rodriguez, Khashayar Vaziri
INTRODUCTION: In addition to increased perioperative morbidity, anastomotic leak following gastric resection for gastric cancer can have detrimental effects on overall and disease-free survival. The risk of anastomotic leak following neoadjuvant therapy remains unknown. The purpose of this study is to investigate the association of preoperative chemotherapy and radiation therapy with postoperative anastomotic leak and additional 30-day morbidity and mortality outcomes following total gastrectomy with reconstruction for gastric cancer using the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP)...
July 25, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28743856/kaposi-sarcoma-in-an-human-immunodeficiency-virus-hiv-seronegative-mediterranean-female-report-of-a-rare-case
#15
Marios Grigoriou, Konstantinia E Kofina, Aristeidis Ioannidis, Domniki K Gerasimidou, Christoforos Efthymiadis, Thomas Zaramboukas
BACKGROUND Kaposi sarcoma is a malignancy commonly linked to HIV infection or immunosuppression. An association with human herpes virus 8 (HHV-8) infection has also been reported. We present a case of classic Kaposi sarcoma in a female Mediterranean patient. CASE REPORT A 57-year-old white female of Greek ethnicity, with no history of HIV infection or immunosuppression, presented to the Surgical Out-patient Department of our Center, with complaints of extensive discolored skin lesion on both legs, initially considered as chronic vein insufficiency...
July 26, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28743834/mid-arm-muscle-circumference-as-a-substantial-factor-against-mortality-among-people-with-elevated-gamma-gaps
#16
Yuan-Ping Chao, Yi-Fen Lai, Tung-Wei Kao, Tao-Chun Peng, Yuan-Yung Lin, Mu-Tsun Shih, Wei-Liang Chen, Li-Wei Wu
Gamma gap is the difference in total serum proteins and albumin and an elevated gamma gap is related to infections, malignancy, and rheumatic diseases. An elevated gamma gap is also associated with higher mortality due to the correlation with inflammatory status. The study aimed to utilize mid-arm muscle circumference (MAMC) to assist in predicting all-cause mortality, cancer mortality, and cardiovascular mortality in people with elevated gamma gaps. Data were obtained from the third U.S. National Health and Nutrition Examination Survey (1988-1994), which contained 14,011 adults aged 20 to 90 years during up to 14...
July 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/28743701/correction-for-chaftari-et-al-a-novel-nonantibiotic-nitroglycerin-based-catheter-lock-solution-for-prevention-of-intraluminal-central-venous-catheter-infections-in-cancer-patients
#17
Anne-Marie Chaftari, Ray Hachem, Ariel Szvalb, Mahnaz Taremi, Bruno Granwehr, George Michael Viola, Sapna Amin, Andrew Assaf, Yazan Numan, Pankil Shah, Ketevan Gasitashvili, Elizabeth Natividad, Ying Jiang, Rebecca Slack, Ruth Reitzel, Joel Rosenblatt, Elie Mouhayar, Issam Raad
No abstract text is available yet for this article.
August 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28743274/risk-factors-and-a-prediction-model-for-lower-limb-lymphedema-following-lymphadenectomy-in-gynecologic-cancer-a-hospital-based-retrospective-cohort-study
#18
Kenji Kuroda, Yasuhiro Yamamoto, Manami Yanagisawa, Akira Kawata, Naoya Akiba, Kensuke Suzuki, Kazutoshi Naritaka
BACKGROUND: Lower limb lymphedema (LLL) is a chronic and incapacitating condition afflicting patients who undergo lymphadenectomy for gynecologic cancer. This study aimed to identify risk factors for LLL and to develop a prediction model for its occurrence. METHODS: Pelvic lymphadenectomy (PLA) with or without para-aortic lymphadenectomy (PALA) was performed on 366 patients with gynecologic malignancies at Yaizu City Hospital between April 2002 and July 2014; we retrospectively analyzed 264 eligible patients...
July 25, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/28743159/chronic-hepatitis-c-virus-infection-and-neurocognitive-function-in-adult-survivors-of-childhood-cancer
#19
Adrienne Studaway, Rohit P Ojha, Tara M Brinkman, Nan Zhang, Malek Baassiri, Pia Banerjee, Matthew J Ehrhardt, Deokumar Srivastava, Leslie L Robison, Melissa M Hudson, Kevin R Krull
BACKGROUND: Cancer survivors transfused with blood products before reliable screening for hepatitis C virus (HCV) are at risk for infection. This study examined the impact of HCV on neurocognitive function and health-related quality of life (HRQOL) among adult survivors of childhood cancer. METHODS: Neurocognitive testing was conducted for 836 adult survivors of childhood cancer (mean age, 35 years [standard deviation, 7.4 years]; time since diagnosis, 29 years [standard deviation, 6...
July 25, 2017: Cancer
https://www.readbyqxmd.com/read/28743129/fibroblast-growth-factor-23-predicts-mortality-and-end-stage-renal-disease-in-a-canadian-asian-population-with-chronic-kidney-disease
#20
Ishwarlal Jialal, Fernando Camacho, Bharat Nathoo, Paul Tam, Roma Pahwa, George G Wu
BACKGROUND: Chronic kidney disease (CKD) is a leading cause of morbidity and mortality. Biomarkers that predict end-stage renal disease (ESRD) and/or mortality could usher in new therapeutics to halt this onslaught. While fibroblast growth factor (FGF)23 can predict both ESRD and mortality, it has not been studied in North American CKD patients of Asian ethnicity. METHOD: This is a prospective investigation about the role of FGF23 in 998 Canadian patients of Asian descent with CKD defined by an estimated glomerular filtration rate (eGFR) <60 mL/min/m2 and followed up for 3 years...
July 26, 2017: Nephron
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