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https://www.readbyqxmd.com/read/28646812/oral-consumption-of-vitamin-k2-for-8-weeks-associated-with-increased-maximal-cardiac-output-during-exercise
#1
Brian K McFarlin, Andrea L Henning, Adam S Venable
Background • Vitamin K1 and K2 are not typically common in a Western diet because they are found in a variety of fermented foods. Vitamin K2 in particular has been demonstrated to restore mitochondrial function and has a key role in production of mitochondrial adenosine triphosphate. Thus, it is reasonable to speculate that dietary supplementation with vitamin K2 could increase the function of muscle with high mitochondrial content (ie, skeletal and cardiac muscle). Objective • The purpose of this study was to determine if 8 wk of dietary supplementation with Vitamin K2 could alter cardiovascular responses to a graded cycle ergometer test...
July 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/28645977/vitamin-d-status-and-associated-factors-among-portuguese-older-adults-results-from-the-nutrition-up-65-cross-sectional-study
#2
Alejandro Santos, Teresa F Amaral, Rita S Guerra, Ana S Sousa, Luisa Álvares, Pedro Moreira, Patrícia Padrão, Cláudia Afonso, Nuno Borges
OBJECTIVES: To evaluate vitamin D status and its associated factors in Portuguese older adults from the Nutrition UP 65 study. DESIGN: Cross-sectional observational study. PARTICIPANTS AND METHODS: Nationwide cluster sample of 1500 Portuguese subjects ≥65 years old. Participants were classified, according to US Institute of Medicine cut-offs, as presenting normal 25-hydroxyvitamin D (25(OH)D) levels (≥50.0 nmol/L), at risk of inadequacy (30...
June 22, 2017: BMJ Open
https://www.readbyqxmd.com/read/28645880/biomarkers-of-airway-and-systemic-inflammation-in-obese-asthmatic-paediatric-patients
#3
H T Nacaroglu, O B Gayret, M Erol, O Buke, O Zengi, M Tasdemir, Z Tasdemir, O Yigit
BACKGROUND: It is thought that airway inflammation is more common in obese asthmatic patients because inflammation is harder to control and does not respond well to glucocorticoid treatment. OBJECTIVE: This study's aim was to investigate the effect of obesity on airway and systemic inflammation in children with asthma and to identify the biomarkers that play a role in this inflammation. METHODS: The study included patients aged 6-16 years who were diagnosed with asthma in the paediatric allergy outpatient clinic of Bagcilar Training and Research Hospital in Turkey...
June 20, 2017: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/28645722/circulating-bone-related-markers-and-ykl-40-versus-her2-and-topo2a-in-bone-metastatic-and-nonmetastatic-breast-cancer-diagnostic-implications
#4
Olfat Gamil Shaker, Hebatullah Samy Helmy
BACKGROUND: The bone represents one of the most common sites of metastases in breast cancer. The aim of the current study was to evaluate the diagnostic potential of several circulating markers to detect metastasis to bones in patients with breast cancer. PATIENTS AND METHODS: Receptor activator of Nuclear Factor-kappa β (NF-Kβ) ligand (RANKL), osteoprotegrin (OPG), vitamin D (VIT D), Chitinase-3-like protein 1; also known as YKL-40, topoisomerase IIα (TOPO2a), and human epidermal growth factor receptor 2 (HER2) were measured in blood samples obtained from 122 patients with breast cancer and 25 healthy controls...
June 7, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28645551/association-between-blood-vitamin-d-and-myocardial-infarction-a-meta-analysis-including-observational-studies
#5
REVIEW
Jizhen Huang, Zhiwei Wang, Zhipeng Hu, Wanli Jiang, Bowen Li
BACKGROUND: The association between blood vitamin D levels and the risk of myocardial infarction (MI) is controversial. This meta-analysis aimed to describe the relationship between MI risk and blood vitamin D levels. METHODS: Online databases were searched in PubMed, EMBASE and Web of science till February 2017 for observational studies in relation to reporting the vitamin D levels in MI cases and non-MI controls. The weighted mean difference (WMD) or odds ratio (OR), with 95% confidence interval (CI), were calculated to evaluate the relationship between MI risk and blood vitamin D levels...
June 20, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28645473/efficacy-and-safety-of-rivaroxaban-versus-warfarin-in-patients-taking-nondihydropyridine-calcium-channel-blockers-for-atrial-fibrillation-from-the-rocket-af-trial
#6
Jeffrey B Washam, Anne S Hellkamp, Yuliya Lokhnygina, Jonathan P Piccini, Scott D Berkowitz, Christopher C Nessel, Richard C Becker, Günter Breithardt, Keith A A Fox, Jonathan L Halperin, Graeme J Hankey, Kenneth W Mahaffey, Daniel E Singer, Manesh R Patel
Non-dihydropyridine calcium channel blockers (non-DHP CCBs) possess combined P-glycoprotein and moderate CYP3A4 inhibition, which may lead to increased exposure of medications that are substrates for these metabolic pathways, such as rivaroxaban. We evaluated the use and outcomes of non-DHP CCBs in patients with atrial fibrillation (AF) in Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF)...
May 29, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28644368/vitamin-d-deficiency-is-not-associated-with-growth-or-the-incidence-of-common-morbidities-among-tanzanian-infants
#7
Christopher R Sudfeld, Karim P Manji, Emily R Smith, Said Aboud, Rodrick Kisenge, Wafaie W Fawzi, Christopher P Duggan
OBJECTIVE: The objective of this study was to examine risk factors for vitamin D deficiency and determine the association of vitamin D status with child growth and incidence of common morbidities among Tanzanian infants. METHODS: A prospective cohort of 581 Tanzanian infants born to HIV-uninfected mothers had serum 25-hydroxyvitamin D (25(OH)D) assessed at 6 weeks and 6 months of age. Infants were seen at monthly clinic visits for growth monitoring until 18 months of age...
June 21, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28643993/the-impact-of-vitamin-d-supplementation-on-serum-cathelicidin-levels-and-the-clinical-course-of-atopic-dermatitis-in-children
#8
Kyriaki Tsotra, Anastasia Garoufi, Lydia Kossiva, Dimitrios Gourgiotis, Theano Tsoukatou, Eleni Katsantoni, Panagiotis Stavropoulos
BACKGROUND: Cathelicidin has been correlated with the pathophysiology of atopic dermatitis (AD). An indirect correlation of vitamin D with the course of the disease has already been reported as it directly affects the levels of cathelicidin. The purpose of the present article is to investigate the impact of vitamin D supplementation on the course of AD. METHODS: We conducted a prospective observational study. The severity of AD was assessed with the clinical tool SCORAD (SCORing Atopic Dermatitis) which is developed by the European Task Force on AD...
June 22, 2017: Minerva Pediatrica
https://www.readbyqxmd.com/read/28643618/heat-stabilised-rice-bran-consumption-by-colorectal-cancer-survivors-modulates-stool-metabolite-profiles-and-metabolic-networks-a-randomised-controlled-trial
#9
Dustin G Brown, Erica C Borresen, Regina J Brown, Elizabeth P Ryan
Rice bran (RB) consumption has been shown to reduce colorectal cancer (CRC) growth in mice and modify the human stool microbiome. Changes in host and microbial metabolism induced by RB consumption was hypothesised to modulate the stool metabolite profile in favour of promoting gut health and inhibiting CRC growth. The objective was to integrate gut microbial metabolite profiles and identify metabolic pathway networks for CRC chemoprevention using non-targeted metabolomics. In all, nineteen CRC survivors participated in a parallel randomised controlled dietary intervention trial that included daily consumption of study-provided foods with heat-stabilised RB (30 g/d) or no additional ingredient (control)...
May 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28643486/comparison-of-intact-pth-and-bio-intact-pth-assays-among-non-dialysis-dependent-chronic-kidney-disease-patients
#10
Yael Einbinder, Sydney Benchetrit, Eliezer Golan, Tali Zitman-Gal
BACKGROUND: The third-generation bio-intact parathyroid hormone (PTH) (1-84) assay was designed to overcome problems associated with the detection of C-terminal fragments by the second-generation intact PTH assay. The two assays have been compared primarily among dialysis populations. The present study evaluated the correlations and differences between these two PTH assays among patients with chronic kidney disease (CKD) stages 3 to 5 not yet on dialysis. METHODS: Blood samples were collected from 98 patients with CKD stages 3 to 5...
September 2017: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/28643272/prevalence-and-risk-factors-for-low-bone-mineral-density-in-ulcerative-colitis
#11
Ram Pratap Singh Bundela, Prachis Ashdhir, Kumar Shwetanshu Narayan, Mukesh Jain, Rupesh Kumar Pokharna, Sandeep Nijhawan
BACKGROUND: Inflammatory bowel disease (IBD) has been associated with increased risk of osteopenia and osteoporosis. Several risk factors contribute to this; however, studies evaluating their association have conflicting results. METHODS: We conducted a cross-sectional study with prospective enrollment of adult ulcerative colitis patients attending the Gastroenterology Department of Sawai Man Singh Hospital, Jaipur Rajasthan between June 2015 and December 2015. Demographic data including age, gender, body mass index (BMI), disease duration, type of disease, prior steroid use and vitamin D levels were recorded and compared with bone mineral density (BMD) using dual-energy X-ray absorptiometry (DEXA)...
June 23, 2017: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/28642854/measurement-uncertainty-in-spine-bone-mineral-density-by-dual-energy-x-ray-absorptiometry
#12
Ae-Ja Park, Jun-Il Yoo, Jee-Hye Choi, Kyun Shik Chae, Chang Geun Kim, Dal Sik Kim
BACKGROUND: The purpose of this study was to calculate the measurement uncertainty of the process of bone mineral density (BMD) analysis using dual energy X-ray absorptiometry with traceability. METHODS: Between March 2015 and October 2016, among healthy participants in their 20s and 30s, the study included those who had not taken calcium, vitamin D supplements and steroids and were without a history of osteoporosis, osteopenia and diseases related to osteoporosis...
May 2017: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/28642665/osteoporosis-in-brazilian-patients-awaiting-knee-arthroplasty
#13
David Sadigursky, Luiz Alberto Barretto, Diogo Maciel Vieira Lobão, Rogério Jamil Fernandes Carneiro, Paulo Oliveira Colavolpe
OBJECTIVE: The primary objective of this study was to determine the prevalence of osteoporosis and osteopenia prior to total knee arthroplasty (TKA) in female patients. As a secondary objective, we evaluated the incidence of hip fractures, types of drugs to treat osteoporosis and serum vitamin D levels. METHOD: This is a transversal, descriptive and observational study which evaluated 60 women above age 55 prior to total knee replacement. RESULTS: Mean patient age was 71...
May 2017: Acta Ortopedica Brasileira
https://www.readbyqxmd.com/read/28642082/clinical-trial-of-the-effects-of-vitamin-d-supplementation-on-psychological-symptoms-and-metabolic-profiles-in-maintenance-methadone-treatment-patients
#14
Amir Ghaderi, Hamid Reza Banafshe, Maryam Motmaen, Morad Rasouli-Azad, Fereshteh Bahmani, Zatollah Asemi
BACKGROUND: Vitamin D deficiency may be associated with some complications including nonspecific musculoskeletal pain and periodontal disease in maintenance methadone treatment (MMT) patients. This study was designed to determine the effect of vitamin D supplementation on psychological symptoms and metabolic profiles in MMT patients. METHODS: This randomized, double-blind, placebo-controlled, clinical trial was carried out among 68 MMT patients. Participants were randomly allocated to receive either 50,000IU vitamin D supplements (n=34) or placebo (n=34) every 2weeks for 12weeks...
June 19, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28641318/comment-on-the-impact-of-vitamin-d-pathway-genetic-variation-and-circulating-25-hydroxyvitamin-d-on-cancer-outcome-systematic-review-and-meta-analysis
#15
Alain Braillon
No abstract text is available yet for this article.
June 22, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28641317/reply-to-comment-on-the-impact-of-vitamin-d-pathway-genetic-variation-and-circulating-25-hydroxyvitamin-d-on-cancer-outcome-systematic-review-and-meta-analysis
#16
L Zgaga, P G Vaughan-Shaw, F O'Sullivan, S M Farrington, E Theodoratou, H Campbell, M G Dunlop
No abstract text is available yet for this article.
June 22, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28640213/the-association-of-serum-25-hydroxyvitamin-d-concentrations-and-elevated-glycated-hemoglobin-values-a-longitudinal-study-of-non-diabetic-participants-of-a-preventive-health-program
#17
Lalani L Munasinghe, Marco F Mastroeni, Silmara S B S Mastroeni, Sarah A Loehr, John Paul Ekwaru, Paul J Veugelers
The prevalence of Type 2 Diabetes (T2D) is sharply on the rise, both in Canada and worldwide. As addressing its root causes, i.e., promotion of healthy lifestyles and weight management, has been largely unsuccessful, new clues for primary prevention seem essential to curbing the increasing public health burden of T2D. In the present study, we examined whether improvements in vitamin D status, i.e., serum 25-hydroxyvitamin D [25(OH)D] concentrations, are paralleled by a reduction in the risk for reaching adverse glycated hemoglobin (HbA1c) levels in a community sample of non-diabetic volunteers participating in a preventive health program that encourages the use of vitamin D...
June 22, 2017: Nutrients
https://www.readbyqxmd.com/read/28640196/vitamin-d%C3%A2-and-25-hydroxyvitamin-d%C3%A2-content-of-retail-white-fish-and-eggs-in-australia
#18
Eleanor Dunlop, Judy Cunningham, Jill L Sherriff, Robyn M Lucas, Heather Greenfield, Jayashree Arcot, Norbert Strobel, Lucinda J Black
Dietary vitamin D may compensate for inadequate sun exposure; however, there have been few investigations into the vitamin D content of Australian foods. We measured vitamin D₃ and 25-hydroxyvitamin D₃ (25(OH)D₃) in four species of white fish (barramundi, basa, hoki and king dory), and chicken eggs (cage and free-range), purchased from five Australian cities. Samples included local, imported and wild-caught fish, and eggs of varying size from producers with a range of hen stocking densities. Raw and cooked samples were analysed using high performance liquid chromatography with photodiode array...
June 22, 2017: Nutrients
https://www.readbyqxmd.com/read/28639252/ethnic-variations-in-serum-25-oh-d-levels-and-bone-ultrasound-attenuation-measurements-in-blacks-and-whites
#19
Rosario Sakamoto, D Thorpe, R Knutsen, L Beeson, S Knutsen
Vitamin D deficiency is more common in Blacks, yet Blacks have lower prevalence of bone fragility fractures or osteoporosis than Whites. Broadband ultrasound attenuation (BUA) has been used to explore the association between serum 25(OH)D levels and bone quality in White and non-white populations. We investigated serum 25(OH)D status with corresponding BUA measurements assessed cross sectionally in a cohort of 232 Blacks and 260 Whites, aged 30-95 years who were part of the calibration study of the large Adventist Health Study-2 (AHS-2)...
June 21, 2017: Journal of Racial and Ethnic Health Disparities
https://www.readbyqxmd.com/read/28638891/effect-of-astragaloside-on-vitamin-d-receptor-expression-after-endothelin-1-induced-cardiomyocyte-injury
#20
Chen Yunzhi, Chen Jiaxu, Gao Jie, Chai Yihui, Li Wen, Qin Zhong
BACKGROUND: Astragaloside, which is one of the main components of Astragalus membranaceus, has been widely used in the treatment of congestive heart failure in China, and it can protect cardiomyocytes. Its mechanism of action remains unclear. Therefore, the present study was carried out to investigate the influence of astragaloside on rat cardiomyocytes stimulated with endothelin-1 (ET-1), and explored the underlying mechanism. MATERIALS AND METHODS: ET-1 was used to stimulate primary rat cardiomyocytes and establish a cardiomyocyte hypertrophy model...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
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