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https://www.readbyqxmd.com/read/27886184/a-view-of-the-current-and-future-role-of-optical-coherence-tomography-in-the-management-of-age-related-macular-degeneration
#1
REVIEW
U Schmidt-Erfurth, S Klimscha, S M Waldstein, H Bogunović
Optical coherence tomography (OCT) has become an established diagnostic technology in the clinical management of age-related macular degeneration (AMD). OCT is being used for primary diagnosis, evaluation of therapeutic efficacy, and long-term monitoring. Computer-based advances in image analysis provide complementary imaging tools such as OCT angiography, further novel automated analysis methods as well as feature detection and prediction of prognosis in disease and therapy by machine learning. In early AMD, pathognomonic features such as drusen, pseudodrusen, and abnormalities of the retinal pigment epithelium (RPE) can be imaged in a qualitative and quantitative way to identify early signs of disease activity and define the risk of progression...
November 25, 2016: Eye
https://www.readbyqxmd.com/read/27834969/the-association-of-geographic-atrophy-and-decreased-renal-function-in-patients-with-age-related-macular-degeneration
#2
H B Leisy, A Rastogi, G Guevara, M Ahmad, R T Smith
PurposeThe purpose of the study was to investigate the association between area and presence of geographic atrophy (GA) and renal function, as measured by glomerular filtration rate (GFR).Patients and methodsWe retrospectively identified patients aged 50-90 years who were assigned an ICD-9 diagnosis code for age-related macular generation (AMD) between January 2012 and January 2016. Patients met inclusion criteria if they had at least one macular spectral domain optical coherence tomography volume scan, one provider note, and one GFR value in the electronic medical record...
November 11, 2016: Eye
https://www.readbyqxmd.com/read/27800275/uveal-melanoma-current-trends-in-diagnosis-and-management
#3
REVIEW
Berçin Tarlan, Hayyam Kıratlı
Uveal melanoma, which is the most common primary intraocular malignancy in adults, arises from melanocytes within the iris, ciliary body and choroid. The diagnosis is based principally on clinical examination of the tumor with biomicroscopy and indirect ophthalmoscopy and confirmed by diagnostic techniques such as ultrasonography, fundus fluorescein angiography and optical coherence tomography. The clinical diagnosis of posterior uveal melanomas can be made when the classical appearance of a pigmented dome-shaped mass is detected on dilated fundus exam...
June 2016: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/27751744/the-alzheimer-s-related-amyloid-beta-peptide-is-internalised-by-r28-neuroretinal-cells-and-disrupts-the-microtubule-associated-protein-2-map-2
#4
George Taylor-Walker, Savannah A Lynn, Eloise Keeling, Rosie Munday, David A Johnston, Anton Page, Jennifer A Scott, Srini Goverdhan, Andrew J Lotery, J Arjuna Ratnayaka
Age-related Macular Degeneration (AMD) is a common, irreversible blinding condition that leads to the loss of central vision. AMD has a complex aetiology with both genetic as well as environmental risks factors, and share many similarities with Alzheimer's disease. Recent findings have contributed significantly to unravelling its genetic architecture that is yet to be matched by molecular insights. Studies are made more challenging by observations that aged and AMD retinas accumulate the highly pathogenic Alzheimer's-related Amyloid beta (Aβ) group of peptides, for which there appears to be no clear genetic basis...
October 15, 2016: Experimental Eye Research
https://www.readbyqxmd.com/read/27403865/problems-with-large-joints-shoulder-conditions
#5
Michael Campbell
Age-related macular degeneration (AMD) causes a progressive loss of photoreceptors in the macula. It is the most common cause of legal blindness in the United States, and some form of AMD is thought to affect more than 9 million individuals. Risk factors include older age, smoking, dyslipidemia, obesity, white race, female sex, and a family history of AMD. There are two types of advanced AMD: nonexudative (dry or geographic atrophy) and exudative (wet or neovascular). Both cause progressive central vision loss with intact peripheral vision...
July 2016: FP Essentials
https://www.readbyqxmd.com/read/27348529/eye-conditions-in-older-adults-age-related-macular-degeneration
#6
REVIEW
Tochi Iroku-Malize, Scott Kirsch
Age-related macular degeneration (AMD) causes a progressive loss of photoreceptors in the macula. It is the most common cause of legal blindness in the United States, and some form of AMD is thought to affect more than 9 million individuals. Risk factors include older age, smoking, dyslipidemia, obesity, white race, female sex, and a family history of AMD. There are two types of advanced AMD: nonexudative (dry or geographic atrophy) and exudative (wet or neovascular). Both cause progressive central vision loss with intact peripheral vision...
June 2016: FP Essentials
https://www.readbyqxmd.com/read/27173377/differentiating-drusen-drusen-and-drusen-like-appearances-associated-with-ageing-age-related-macular-degeneration-inherited-eye-disease-and-other-pathological-processes
#7
REVIEW
Kamron N Khan, Omar A Mahroo, Rehna S Khan, Moin D Mohamed, Martin McKibbin, Alan Bird, Michel Michaelides, Adnan Tufail, Anthony T Moore
Drusen are discussed frequently in the context of their association with age-related macular degeneration (AMD). Some types may, however, be regarded as a normal consequence of ageing; others may be observed in young age groups. They also occur in a number of inherited disorders and some systemic conditions. Whilst drusen are classically located external (sclerad) to the retinal pigment epithelium, accumulations of material internal (vitread to) this layer can display a drusen-like appearance, having been variously termed pseudodrusen or subretinal drusenoid deposits...
July 2016: Progress in Retinal and Eye Research
https://www.readbyqxmd.com/read/27159771/coronary-artery-disease-and-reticular-macular-disease-a-subphenotype-of-early-age-related-macular-degeneration
#8
Rachel M Cymerman, Adam H Skolnick, William J Cole, Camellia Nabati, Christine A Curcio, R Theodore Smith
PURPOSE: Reticular macular disease (RMD) is the highest risk form of early age-related macular degeneration and also specifically confers decreased longevity. However, because RMD requires advanced retinal imaging for adequate detection of its characteristic subretinal drusenoid deposits (SDD), it has not yet been completely studied with respect to coronary artery disease (CAD), the leading cause of death in the developed world. Because CAD appears in middle age, our purpose was to screen patients aged 45-80 years, documented either with or without CAD, to determine if CAD is associated with RMD...
November 2016: Current Eye Research
https://www.readbyqxmd.com/read/27039021/correlation-of-histologic-features-with-in%C3%A2-vivo-imaging-of-reticular-pseudodrusen
#9
Ursula Greferath, Robyn H Guymer, Kirstan A Vessey, Kate Brassington, Erica L Fletcher
PURPOSE: To determine the histologic and cellular correlates in the retina and retinal pigment epithelium (RPE) with the presence of optical coherence tomography-defined reticular pseudodrusen (RPD). DESIGN: Observation case using immunocytochemistry of an exenterated eye with immediate fixation after removal. PARTICIPANTS: Two patients, one with confirmed RPD and the other with mid-peripheral drusen, underwent multimethod imaging before exenteration and immediate fixation of the posterior eyecup for high-resolution immunocytochemical analysis...
June 2016: Ophthalmology
https://www.readbyqxmd.com/read/26940163/relating-retinal-morphology-and-function-in-aging-and-early-to-intermediate-age-related-macular-degeneration-subjects
#10
Monica B Sevilla, Gerald McGwin, Eleonora M Lad, Mark Clark, Eric L Yuan, Sina Farsiu, Christine A Curcio, Cynthia Owsley, Cynthia A Toth
PURPOSE: To evaluate relationships between age-related macular degeneration (AMD) morphology on spectral-domain optical coherence tomography (SDOCT) and visual function. DESIGN: Cross-sectional, observational. METHODS: From the Alabama Study on Early AMD baseline visit, visual acuity, cone-mediated sensitivity, rod-mediated dark adaptation, and SDOCT were obtained in 1 eye per subject with no apparent retinal aging (n = 15), normal aging (n = 15), early AMD (n = 15), and intermediate AMD (n = 46)...
May 2016: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/26871899/geographic-atrophy-and-choroidal-neovascularization-in-the-same-eye-a-review
#11
REVIEW
Patrick Kaszubski, Tal Ben Ami, Celine Saade, R Theodore Smith
Geographic atrophy (GA) and choroidal neovascularization (CNV), the two late forms of age-related macular degeneration, are generally considered two distinct entities. However, GA and CNV can occur simultaneously in the same eye, with GA usually occurring first. The prevalence of this combined entity is higher in histological studies than in clinical studies. No distinct systemic or genetic risk characteristics are associated with the combined GA/CNV entity, although on clinical examination and retinal imaging it can feature drusen or subretinal drusenoid deposits...
2016: Ophthalmic Research
https://www.readbyqxmd.com/read/26599251/optical-coherence-tomography-angiography-imaging-of-quiescent-choroidal-neovascularization-in-age-related-macular-degeneration
#12
Márcio B Nehemy, Daniel N Brocchi, Carlos E Veloso
A 67-year-old asymptomatic man presented with bilateral drusen. Spectral-domain optical coherence tomography (OCT) showed no signs of choroidal neovascularization (CNV) and no intraretinal or subretinal fluid. OCT angiography (OCTA) revealed the presence of a type 1 CNV in the right eye. Management options were discussed with the patient, who opted for a clinical follow-up. This is the first description demonstrating the OCTA characteristics of a quiescent CNV secondary to age-related macular degeneration.
November 2015: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/26536099/choroidal-thickening-in-patients-with-cuticular-drusen-combined-with-vitelliform-macular-detachment
#13
Sarah Mrejen-Uretsky, Sandrine Ayrault, Sylvia Nghiem-Buffet, Gabriel Quentel, Salomon Y Cohen
PURPOSE: To analyze the subfoveal choroidal thickness (SFCT) in patients with cuticular drusen. METHODS: Retrospective, monocentric, study of consecutive patients examined with enhanced depth imaging spectral domain optical coherence tomography (EDI SD-OCT, Cirrus, Zeiss) between 2009 and 2014 in a tertiary care center. Measurements of the height of the subfoveal vitelliform detachment and SFCT were manually performed. RESULTS: Thirteen patients, 3 men and 10 women, aged from 35 to 73 (mean: 53...
June 2016: Retina
https://www.readbyqxmd.com/read/26383711/type-2-subretinal-neovascularization-in-age-related-macular-degeneration-associated-with-pure-reticular-pseudodrusen-phenotype
#14
Jonathan Naysan, Jesse J Jung, Kunal K Dansingani, Chandrakumar Balaratnasingam, K Bailey Freund
PURPOSE: To report the association of pure type 2 neovascularization (NV) in age-related macular degeneration occurring almost exclusively in patients with reticular pseudodrusen. METHODS: An observational retrospective cohort study of all eyes receiving antivascular endothelial growth factor therapy for newly diagnosed neovascular age-related macular degeneration by a single practitioner over a 6-year period. Only patients with treatment-naive, pure type 2 NV who also had either pre-neovascular imaging of the study eye or imaging of a nonneovascular fellow eye available to determine baseline characteristics including drusen type and choroidal thickness were incuded...
March 2016: Retina
https://www.readbyqxmd.com/read/26298717/the-onion-sign-in-neovascular-age-related-macular-degeneration-represents-cholesterol-crystals
#15
Claudine E Pang, Jeffrey D Messinger, Emma C Zanzottera, K Bailey Freund, Christine A Curcio
PURPOSE: To investigate the frequency, natural evolution, and histologic correlates of layered, hyperreflective, subretinal pigment epithelium (sub-RPE) lines, known as the onion sign, in neovascular age-related macular degeneration (AMD). DESIGN: Retrospective observational cohort study and experimental laboratory study. PARTICIPANTS: Two hundred thirty eyes of 150 consecutive patients with neovascular AMD and 40 human donor eyes with histopathologic diagnosis of neovascular AMD...
November 2015: Ophthalmology
https://www.readbyqxmd.com/read/26270411/posterior-scleral-bowing-with-choroidal-nevus-on-enhanced-depth-imaging-optical-coherence-tomography
#16
Rosa Dolz-Marco, Murat Hasanreisoglu, Jerry A Shields, Carol L Shields
IMPORTANCE: Recognition of posterior scleral bowing with choroidal nevus is essential to avoid an underestimation of tumor thickness. OBJECTIVE: To describe a particular observation of posterior scleral bowing associated with choroidal nevus on enhanced-depth imaging (EDI) optical coherence tomography (OCT). DESIGN, SETTING, AND PARTICIPANTS: Retrospective observational case series at a referral center involving 17 eyes of 17 patients. Patients were seen from June 2013 to July 2014, with all data collected and analyzed from June 2014 to July 2014...
October 2015: JAMA Ophthalmology
https://www.readbyqxmd.com/read/26148443/sd-oct-to-distinguish-papilledema-from-pseudopapilledema
#17
V M Asensio-Sánchez, L Trujillo-Guzmán
CASES REPORT: Two patients presented with headache and bilateral papillary edema. Patient 1 was found to have a papilledema (P) with intracranial pressure of 32cmH2O. Patient 2 was found to have a migraine with a pseudopapilledema (PP) (optic nerve head drusen). SD-OCT was used to image the optic disc, subretinal hyporeflective space (SHS), and alpha-angle (Aα). DISCUSSION: Optic disc SD-OCT may be useful for differentiating disc morphology in P and PP. The area of the SHS and the Aα were higher in the P patient than in the patient with PP...
October 2015: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/26131588/reticular-pseudodrusen-on-infrared-imaging-are-topographically-distinct-from-subretinal-drusenoid-deposits-on-en-face-optical-coherence-tomography
#18
Michael J Heiferman, Joshua K Fernandes, Marion Munk, Rukhsana G Mirza, Lee M Jampol, Amani A Fawzi
PURPOSE: To evaluate the quantitative and topographic relationship between reticular pseudodrusen (RPD) on infrared reflectance (IR) and subretinal drusenoid deposits (SDD) on en face volumetric spectral domain optical coherence tomography. METHODS: Reticular pseudodrusen were marked on IR images by a masked observer. Subretinal drusenoid deposits were visualized on en face sections of spectral domain optical coherence tomography below the external limiting membrane and identified by a semiautomated technique...
December 2015: Retina
https://www.readbyqxmd.com/read/26110523/submillimeter-choroidal-melanoma-detection-by-enhanced-depth-imaging-optical-coherence-tomography-in-a-patient-with-oculodermal-melanocytosis
#19
Zachary Daitch, Carol L Shields, Emil A T Say, Arman Mashayekhi, Jerry A Shields
PURPOSE: To describe a tiny subclinical choroidal melanoma visualized only with enhanced depth imaging optical coherence tomography in a newly symptomatic patient with known oculodermal melanocytosis. METHODS: Case report. RESULTS: A 52-year-old white man with heterochromia and known oculodermal melanocytosis of the right eye, followed for 2 years without change, developed blurred vision and was referred for possible central serous chorioretinopathy...
2016: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/26077580/reticular-pseudodrusen-in-sorsby-fundus%C3%A2-dystrophy
#20
Martin Gliem, Philipp L Müller, Elisabeth Mangold, Hanno J Bolz, Heidi Stöhr, Bernhard H F Weber, Frank G Holz, Peter Charbel Issa
PURPOSE: To investigate the association of reticular pseudodrusen (RPD) with Sorsby fundus dystrophy (SFD). DESIGN: Prospective, monocenter, cross-sectional case series. SUBJECTS: Sixteen patients of 4 unrelated families with SFD caused by mutations in TIMP3. METHODS: All subjects underwent multimodal imaging including near-infrared (NIR) reflectance and fundus autofluorescence with a confocal scanning laser ophthalmoscope and spectral-domain optical coherence tomography (SD OCT)...
August 2015: Ophthalmology
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