keyword
https://read.qxmd.com/read/37542615/subclinical-angioid-streaks-with-pseudodrusen-a-new-phenotype-of-age-related-macular-degeneration
#21
JOURNAL ARTICLE
Riccardo Sacconi, Beatrice Tombolini, Ilaria Zucchiatti, Andrea Servillo, Matteo Menean, Giulio Falco Alessandrini, Lea Querques, Francesco Prascina, Peter Charbel Issa, Francesco Bandello, Giuseppe Querques
INTRODUCTION: To describe subclinical angioid streaks (AS) as a frequent, peculiar age-related macular degeneration (AMD) phenotype, comparing features of eyes with subclinical AS with those of eyes with AMD without AS. METHODS: This was a retrospective, observational study. Among a patient cohort with AMD, we selected patients without known causes for AS whose eyes showed signs of angioid streaks (AS) on structural optical coherence tomography (OCT) but not on fundus examination...
August 5, 2023: Ophthalmology and Therapy
https://read.qxmd.com/read/37527696/investigation-of-the-choroidal-structure-in-non-neovascular-age-related-macular-degeneration-patients-with-reticular-pseudodrusen
#22
JOURNAL ARTICLE
Cumali Degirmenci, Filiz Afrashi, Semir Yarımada, Serap Bilge Çeper, Serhad Nalçacı, Cezmi Akkın, Jale Mentes
BACKGROUND: This study aimed to compare choroidal thickness, total choroidal area (TCA), luminal area (LA), stromal area (SA) and choroidal vascularity index (CVI) in patients with reticular pseudodrusen (RPD) and drusen. METHODS: A total of 100 eyes of 100 patients with non-neovascular age related macular degeneration (AMD) with five or more medium drusen (63-125 µm) and RPD in two or more quadrants were recruited to the study. 48 eyes of 48 patients with RPD were assigned as Group 1 and 52 eyes of 52 patients with drusen were assigned as Group 2...
July 30, 2023: Photodiagnosis and Photodynamic Therapy
https://read.qxmd.com/read/37315571/low-dose-supplementation-with-retinol-improves-retinal-function-in-eyes-with-age-related-macular-degeneration-but-without-reticular-pseudodrusen
#23
JOURNAL ARTICLE
Kristina Pfau, Brett G Jeffrey, Catherine A Cukras
AIMS: To determine the functional impact of oral Vitamin A supplementation in patients with intermediate age-related macular degeneration (iAMD) with and without reticular pseudodrusen (RPD) demonstrating dysfunction in dark adaptation (DA). METHODS: Five patients with iAMD and without RPD (AMD group; mean ± SD age 78.0 ± 4.7 years) and seven with RPD (RPD group; age 74.1 ± 11.2 years) were supplemented with 16,000 IU of Vitamin A palmitate for 8 weeks...
June 9, 2023: Retina
https://read.qxmd.com/read/37302656/clinical-characteristics-and-progression-of-geographic-atrophy-in-a-japanese-population
#24
JOURNAL ARTICLE
Yukiko Sato, Naoko Ueda-Arakawa, Ayako Takahashi, Yasunori Miyara, Chikako Hara, Yoko Kitajima, Ruka Maruko, Moeko Kawai, Hajime Takahashi, Hideki Koizumi, Ryo Kawasaki, Maiko Maruyama-Inoue, Yasuo Yanagi, Tomohiro Iida, Kanji Takahashi, Taiji Sakamoto, Akitaka Tsujikawa
PURPOSE: To elucidate the clinical characteristics and progression rate of geographic atrophy (GA) associated with age-related macular degeneration (AMD) in a Japanese population. DESIGN: Retrospective, multicenter, observational study. PARTICIPANTS: A total of 173 eyes from 173 patients from six university hospitals in Japan were included. Of 173 study eyes, 101 eyes from 101 patients were included in the follow-up group. All patients were Japanese, aged ≥ 50 years, and had definite GA associated with AMD in at least one eye...
June 9, 2023: Ophthalmology Retina
https://read.qxmd.com/read/37292179/reticular-pseudodrusen-interreader-agreement-of-evaluation-on-oct-imaging-in-age-related-macular-degeneration
#25
JOURNAL ARTICLE
Zhichao Wu, Steffen Schmitz-Valckenberg, Barbara A Blodi, Frank G Holz, Glenn J Jaffe, Sandra Liakopoulos, Srinivas R Sadda, Mari Bonse, Tyler Brown, John Choong, Bailey Clifton, Giulia Corradetti, Federico Corvi, Andrew C Dieu, Vivienne Dooling, Jeong W Pak, Marlene Saßmannshausen, Cindy Skalak, Sarah Thiele, Robyn H Guymer
PURPOSE: To determine the interreader agreement for reticular pseudodrusen (RPD) assessment on combined infrared reflectance (IR) and OCT imaging in the early stages of age-related macular degeneration across a range of different criteria to define their presence. DESIGN: Interreader agreement study. PARTICIPANTS: Twelve readers from 6 reading centers. METHODS: All readers evaluated 100 eyes from individuals with bilateral large drusen for the following: (1) the presence of RPD across a range of different criteria and (2) the number of Stage 2 or 3 RPD lesions (from 0 to ≥ 5 lesions) on an entire OCT volume scan and on a selected OCT B-scan...
December 2023: Ophthalmol Sci
https://read.qxmd.com/read/37278414/role-of-sleep-disordered-breathing-in-age-related-macular-degeneration
#26
JOURNAL ARTICLE
Wendy Ying Fang, Palaniraj Rama Raj, Zhichao Wu, Carla Abbott, Chi D Luu, Matthew Naughton, Robyn H Guymer
AIMS: To examine the association between obstructive sleep apnoea (OSA) and age-related macular degeneration (AMD), and the subphenotype of AMD with reticular pseudodrusen (RPD). METHODS: Case-control study with 351 participants (211 AMD and 140 controls) using the Epworth Sleepiness Scale (ESS) and the STOP-BANG Questionnaire (SBQ) validated sleep questionnaires. Participant risk of having moderate-to-severe OSA was determined using a binary risk scale based on the ESS and SBQ combined and an ordinal risk scale based on the SBQ...
May 2023: BMJ Open Ophthalmology
https://read.qxmd.com/read/37271137/inner-retinal-thickness-and-vasculature-in-patients-with-reticular-pseudodrusen
#27
JOURNAL ARTICLE
Fritz Gerald P Kalaw, Varsha Alex, Evan Walker, Dirk-Uwe Bartsch, William R Freeman, Shyamanga Borooah
INTRODUCTION: To investigate retinal layer thickness and vessel density differences between patients with reticular pseudodrusen (RPD) and intermediate dry age-related macular degeneration (iAMD). METHODS: Participants included in the study were patients diagnosed by retinal specialists with RPD, iAMD, and both RPD and iAMD at our academic referral center, seen from May 2021 until February 2022. The central 3 mm retinal thickness was measured using spectral-domain optical coherence tomography (SD-OCT) (Heidelberg Spectralis HRA+OCT System; Heidelberg Engineering, Heidelberg, Germany)...
June 2, 2023: Ophthalmic Research
https://read.qxmd.com/read/37197703/geographic-atrophy-in-age-related-macular-degeneration-a-tale-of-two-stages
#28
JOURNAL ARTICLE
Tiarnan D L Keenan
PURPOSE: To examine disease progression in age-related macular degeneration (AMD) at 2 distinct stages, progression to geographic atrophy (GA) versus GA expansion, by comparison of the risk and protective factors at each stage. DESIGN: Perspective. SUBJECTS: Individuals at risk of GA or with GA. MAIN OUTCOME MEASURES: Progression to GA and GA expansion rate. METHODS: Critical synthesis of the literature on risk and protective factors, both environmental and genetic, for progression to GA versus GA expansion in AMD...
September 2023: Ophthalmol Sci
https://read.qxmd.com/read/37085233/disentangling-the-impact-of-reticular-pseudodrusen-phenotype-and-the-arms2-htra1-risk-allele-in-geographic-atrophy-the-areds-2-study-report-32
#29
EDITORIAL
Bonnie B Huang, Amani A Fawzi
No abstract text is available yet for this article.
May 2023: Ophthalmology
https://read.qxmd.com/read/37052925/decreased-macular-choriocapillaris-perfusion-in-eyes-with-macular-reticular-pseudodrusen-imaged-with-swept-source-oct-angiography
#30
JOURNAL ARTICLE
Jianqing Li, Ziyu Liu, Jie Lu, Mengxi Shen, Yuxuan Cheng, Nadia Siddiqui, Hao Zhou, Qinqin Zhang, Jeremy Liu, Gissel Herrera, Farhan E Hiya, Giovanni Gregori, Ruikang K Wang, Philip J Rosenfeld
PURPOSE: To determine if macular reticular pseudodrusen (RPD) were associated with markers of impaired macular choroidal perfusion, we investigated measurements of macular choriocapillaris (CC) flow deficits (FDs), CC thickness, and mean choroidal thickness (MCT) in eyes with macular RPD compared with normal eyes and eyes with soft drusen. METHODS: Eyes with intermediate age-related macular degeneration (iAMD) and normal eyes underwent 6 × 6 mm swept-source optical coherence tomography angiography (SS-OCTA) imaging to diagnose macular RPD, occupying over 25% of the fovea-centered 5 mm diameter circle, and measure outer retinal layer (ORL) thickness, CC FDs, CC thickness, MCT, and choroidal vascularity index (CVI) using previously published strategies within the same fovea-centered 5 mm circle...
April 3, 2023: Investigative Ophthalmology & Visual Science
https://read.qxmd.com/read/36937046/serum-mirna-modulations-indicate-changes-in-retinal-morphology
#31
JOURNAL ARTICLE
Riemke Aggio-Bruce, Ulrike Schumann, Adrian V Cioanca, Fred K Chen, Samuel McLenachan, Rachael C Heath Jeffery, Shannon Das, Riccardo Natoli
BACKGROUND: Age-related macular degeneration (AMD) is the leading cause of vision loss in the developed world and the detection of its onset and progression are based on retinal morphological assessments. MicroRNA (miRNA) have been explored extensively as biomarkers for a range of neurological diseases including AMD, however differences in experimental design and the complexity of human biology have resulted in little overlap between studies. Using preclinical animal models and clinical samples, this study employs a novel approach to determine a serum signature of AMD progression...
2023: Frontiers in Molecular Neuroscience
https://read.qxmd.com/read/36933125/yellow-subthreshold-micropulse-laser-in-retinal-diseases-an-in-depth-analysis-and-review-of-the-literature
#32
REVIEW
Claudio Iovino, Clemente Maria Iodice, Danila Pisani, Andrea Rosolia, Francesco Testa, Giuseppe Giannaccare, Jay Chhablani, Francesca Simonelli
Yellow subthreshold micropulse laser (YSML) is a retinal laser capable of inducing a biologic response without causing thermal damage to the targeted tissue. The 577-nm YSML is delivered to the retina abiding by different protocols in which wavelength, power, duration, spot size and number of spots can be properly set to achieve the most effective and safe treatment response in various chorioretinal disorders. The ultrashort trains of power modulate the activation of the retinal pigment epithelium cells and intraretinal cells, such as Müller cells, causing no visible retinal scars...
June 2023: Ophthalmology and Therapy
https://read.qxmd.com/read/36815871/the-development-of-suspended-scattering-particles-in-motion-in-a-patient-with-exudative-reticular-pseudodrusen
#33
JOURNAL ARTICLE
Yusuf Kemal Durlu
The development and characteristics of suspended scattering particles in motion (SSPiMs) in a patient with exudative reticular pseudodrusen (ERPD) are reported using multimodal imaging modalities. An 82-year-old woman was referred because of persistent macular edema during intravitreal injections of bevacizumab. ERPD associated with types I and II (mixed type) macular neovascularization in both eyes was diagnosed. Bilateral flat irregular pigment epithelial detachments were associated with macular neovascularization in both eyes by optical coherence tomography...
2023: Case Reports in Ophthalmology
https://read.qxmd.com/read/36736896/nascent-geographic-atrophy-as-a-predictor-of-type-3-mnv-development
#34
JOURNAL ARTICLE
Riccardo Sacconi, David Sarraf, SriniVas R Sadda, K Bailey Freund, Andrea Servillo, Meira Miri Fogel Levin, Eliana Costanzo, Giulia Corradetti, Diogo Cabral, Dinah Zur, Omer Trivizki, Mariacristina Parravano, Francesco Bandello, Anat Loewenstein, Giuseppe Querques
PURPOSE: To investigate the association of nascent geographic atrophy (GA) preceding the development of exudative type 3 macular neovascularization (MNV) in patients with age-related macular degeneration (AMD). DESIGN: Retrospective longitudinal study. PARTICIPANTS: AMD patients diagnosed with treatment-naïve exudative type 3 MNV in one or both eyes were evaluated. Inclusion criteria included serial tracked structural optical coherence tomography (OCT) examinations for ≥ 2 years prior to the detection of exudative type 3 MNV...
February 1, 2023: Ophthalmology Retina
https://read.qxmd.com/read/36695800/pattern-and-characteristics-of-drusen-subtypes-in-chinese-and-indian-populations-in-singapore
#35
JOURNAL ARTICLE
Kengo Takahashi, Youngseok Song, Kai Xiong Cheong, Beau J Fenner, Kelvin Yi Chong Teo, Miao Li Chee, Hengtong Li, Yih-Chung Tham, Chui Ming Gemmy Cheung, Ching-Yu Cheng, Tien Yin Wong, Yasuo Yanagi, Anna C S Tan
PURPOSE: To report the pattern and characteristics of drusen subtypes in Asian populations and the association with choroidal thickness. METHODS: This is the cross-sectional analysis of the population-based cohort study. Two thousand three hundred and fifty-three eyes of 1,336 Chinese and Indian participants aged older than 50 years, eyes with best-corrected visual acuity better than 20/60, and without other retinal diseases were recruited. Pachydrusen, reticular pseudodrusen, soft and hard drusen were graded on both color fundus photographs, and optical coherence tomography imaging with automated segmentation yielding and measurements of choroidal thickness...
February 1, 2023: Retina
https://read.qxmd.com/read/36572671/longitudinal-change-of-reticular-pseudodrusen-area-in-ultrawide-field-imaging
#36
JOURNAL ARTICLE
Je Moon Yoon, Young Joo Choi, Don-Il Ham
This study aimed to investigate the longitudinal change in the reticular pseudodrusen (RPD) area in the fundus and its association with late age-related macular degeneration (AMD). 91 RPD eyes (55 patients; age 67.9 ± 7.3 years) with > 5 years' follow-up (6.8 ± 0.9 years) from a single medical center were enrolled. Ultrawide-field photography images were analyzed using the concentric rings method, and the RPD area was semi-quantitatively classified according to the affected segment number into central, intermediate, and extensive types...
December 26, 2022: Scientific Reports
https://read.qxmd.com/read/36563964/characteristics-and-spatial-distribution-of-structural-features-in-age-related-macular-degeneration-a-macustar-study-report
#37
JOURNAL ARTICLE
Marlene Saßmannshausen, Charlotte Behning, Jonas Weinz, Lukas Goerdt, Jan H Terheyden, Petrus Chang, Matthias Schmid, Stephen H Poor, Nadia Zakaria, Robert P Finger, Frank G Holz, Maximilian Pfau, Steffen Schmitz-Valckenberg, Sarah Thiele
PURPOSE: To report the prevalence and topographic distribution of structural characteristics in study participants with age-related macular degeneration (AMD) and controls in the cross-sectional study part of the MACUSTAR study (ClinicalTrials.gov Identifier: NCT03349801). DESIGN: European, multicenter cohort study. SUBJECTS: 301 eyes of 301 subjects with early (n=34), intermediate (n=168) and late AMD (n=43), as well as eyes without any AMD features (n=56)...
December 20, 2022: Ophthalmology Retina
https://read.qxmd.com/read/36481221/reticular-pseudodrusen-status-arms2-htra1-genotype-and-geographic-atrophy-enlargement-age-related-eye-disease-study-2-report-32
#38
JOURNAL ARTICLE
Elvira Agrón, Amitha Domalpally, Catherine A Cukras, Traci E Clemons, Qingyu Chen, Anand Swaroop, Zhiyong Lu, Emily Y Chew, Tiarnan D L Keenan
PURPOSE: To determine whether reticular pseudodrusen (RPD) status and/or ARMS2/HTRA1 genotype are associated with altered geographic atrophy (GA) enlargement rate, and to analyze potential mediation of genetic effects by RPD status. DESIGN: Post hoc analysis of a cohort within the Age-Related Eye Disease Study 2 (AREDS2) controlled clinical trial. PARTICIPANTS: 771 eyes (563 participants, mean age 74.8 years) with GA. METHODS: GA area was measured by planimetry from color fundus photographs at annual visits...
December 5, 2022: Ophthalmology
https://read.qxmd.com/read/36480897/-the-research-progress-of-multimodal-imaging-for-the-diagnosis-of-reticular-pseudodrusen
#39
JOURNAL ARTICLE
Q G Guo, X H Guo, S Y Li, B Lei
The emergence and development of multimodal imaging techniques, such as optical coherence tomography, fundus autofluorescence and adaptive optics, make it much easier to differentiate reticular pseudodrusen (RPD) from other fundus lesions. It is of great significance to understand the imaging characteristics of RPD observed with multimodal imaging techniques. This article reviews the formation mechanism and multimodal imaging characteristics of RPD, so as to provide help for better identification of RPD and assessment of the development and prognosis of the disease...
December 11, 2022: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://read.qxmd.com/read/36458946/a-deep-learning-framework-for-the-detection-and-quantification-of-reticular-pseudodrusen-and-drusen-on-optical-coherence-tomography
#40
JOURNAL ARTICLE
Roy Schwartz, Hagar Khalid, Sandra Liakopoulos, Yanling Ouyang, Coen de Vente, Cristina González-Gonzalo, Aaron Y Lee, Robyn Guymer, Emily Y Chew, Catherine Egan, Zhichao Wu, Himeesh Kumar, Joseph Farrington, Philipp L Müller, Clara I Sánchez, Adnan Tufail
PURPOSE: The purpose of this study was to develop and validate a deep learning (DL) framework for the detection and quantification of reticular pseudodrusen (RPD) and drusen on optical coherence tomography (OCT) scans. METHODS: A DL framework was developed consisting of a classification model and an out-of-distribution (OOD) detection model for the identification of ungradable scans; a classification model to identify scans with drusen or RPD; and an image segmentation model to independently segment lesions as RPD or drusen...
December 1, 2022: Translational Vision Science & Technology
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