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Reticular Pseudodrusen

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https://www.readbyqxmd.com/read/27870798/retinal-angiomatous-proliferation-diagnosis-a-multiimaging-approach
#1
Vittoria Ravera, Ferdinando Bottoni, Andrea Giani, Mario Cigada, Giovanni Staurenghi
PURPOSE: To identify signs occurring more frequently in retinal angiomatous proliferation (RAP) lesions compared with other types of choroidal neovascularization (CNV) in age-related macular degeneration. METHODS: In this cross-sectional retrospective study, 30 patients were evaluated. These signs were correlated with the type of CNV: shunting of blood flow to the lesion by fluorescein angiography, late leakage by indocyanine green angiography, intraretinal cysts and retinal pigmented epithelium interruption along the retinal pigmented epithelium detachment with a hyperreflective oval area by spectral domain optical coherence tomography, and presence of reticular pseudodrusen by infrared light...
December 2016: Retina
https://www.readbyqxmd.com/read/27856030/comparison-between-widefield-en-face-swept-source-oct-and-conventional-multimodal-imaging-for-the-detection-of-reticular-pseudodrusen
#2
Karen B Schaal, Andrew D Legarreta, William J Feuer, Giovanni Gregori, Qianqian Cheng, John E Legarreta, Mary K Durbin, Paul F Stetson, Sophie Kubach, Philip J Rosenfeld
PURPOSE: The ability to detect reticular pseudodrusen (RPD)/subretinal drusenoid deposits (SDDs) using 12×12-mm widefield en face swept-source optical coherence tomography (SS-OCT) imaging was compared with conventional multimodal imaging (color, fundus autofluorescence (FAF), and infrared reflectance [IR] imaging) in eyes with nonexudative age-related macular degeneration (AMD). DESIGN: Cross-sectional study. PARTICIPANTS: Patients with nonexudative AMD were prospectively enrolled in an SS-OCT imaging study at the Bascom Palmer Eye Institute...
November 14, 2016: Ophthalmology
https://www.readbyqxmd.com/read/27849311/choroidal-thickness-and-choroidal-vessel-density-in-nonexudative-age-related-macular-degeneration-using-swept-source-optical-coherence-tomography-imaging
#3
Fang Zheng, Giovanni Gregori, Karen B Schaal, Andrew D Legarreta, Andrew R Miller, Luiz Roisman, William J Feuer, Philip J Rosenfeld
Purpose: To analyze the relationship between choroidal thickness and the distribution of choroidal blood vessels in eyes with nonexudative AMD. Methods: Eyes with a diagnosis of nonexudative AMD were imaged using a prototype 100-kHz swept-source (SS) optical coherence tomography (OCT) instrument (Carl Zeiss Meditec, Dublin, CA, USA) with a central wavelength of 1050 nm. We used an OCT cube scan pattern consisting of 512 × 512 A-scans over a 12 × 12 mm retinal area...
November 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27794427/choriocapillaris-non-perfusion-is-associated-with-poor-visual-acuity-in-eyes-with-reticular-pseudodrusen
#4
Peter L Nesper, Brian T Soetikno, Amani A Fawzi
PURPOSE: To study choriocapillaris blood flow in age-related macular degeneration (AMD) using optical coherence tomography angiography (OCTA) and study its correlation to vision (VA) in eyes with reticular pseudodrusen (RPD) versus those with drusen without RPD (drusen). DESIGN: Cross-sectional study METHODS: Patients with either drusen or RPD in early AMD underwent OCTA imaging of the superior, inferior, and/or nasal macula. We quantified "percent choriocapillaris area of non-perfusion" (PCAN) in eyes with RPD versus those with drusen...
October 26, 2016: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/27768796/epidemiology-of-reticular-pseudodrusen-in-age-related-macular-degeneration-the-rotterdam-study
#5
Gabriëlle H S Buitendijk, Ada J Hooghart, Corina Brussee, Paulus T V M de Jong, Albert Hofman, Johannes R Vingerling, Caroline C W Klaver
Purpose: Reticular pseudodrusen (RPD) are considered to be a distinct feature in AMD. Population studies have studied the epidemiology of RPD using standard color fundus photographs (CFP). However, recent studies have shown that RPD are better imaged using near-infrared (NIR) imaging. We studied the epidemiology of RPD in a large population-based study using NIR and CFP. Methods: Participants aged 65+ years from the Rotterdam Study underwent ophthalmologic examination including NIR and CFP...
October 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27768118/clinical-features-and-long-term-progression-of-reticular-pseudodrusen-in-age-related-macular-degeneration-findings-from-a-multicenter-cohort
#6
J Q Gil, J P Marques, R Hogg, C Rosina, M L Cachulo, A Santos, G Staurenghi, U Chakravarthy, R Silva
PurposeTo determine whether reticular pseudodrusen (RPD) confer a long-term increased risk of progression to late age-related macular degeneration (AMD) in the fellow eye of patients with unilateral wet-AMD.Patients and methodsThis was a multicenter, combined prospective and retrospective, longitudinal, observational, study. Patients with wet-AMD in one eye were recruited from two centers and evaluated on the risk of progression to late-AMD in the second eye (study eye). A minimum follow-up of 5 years was required, unless progression occurred first...
October 21, 2016: Eye
https://www.readbyqxmd.com/read/27756079/assessment-of-retinotopic-rod-photoreceptor-function-using-a-dark-adapted-chromatic-perimeter-in-intermediate-age-related-macular-degeneration
#7
Rogan G Fraser, Rose Tan, Lauren N Ayton, Emily Caruso, Robyn H Guymer, Chi D Luu
Purpose: We determine the feasibility of using a dark-adapted chromatic (DAC) perimeter to obtain dark-adapted static and dynamic rod function at multiple retinal locations, and compare these functional parameters between subjects with intermediate age-related macular degeneration (AMD) and normal controls. Methods: Perimetric dark-adapted retinal sensitivities for the 505 and 620 nm stimuli across 7 retinal locations within the central 12° were repeatedly measured after exposing to a single photobleach in 22 intermediate AMD subjects and 8 controls...
October 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27668639/fundus-autofluorescence-in-age-related-macular-degeneration
#8
Angelica Ly, Lisa Nivison-Smith, Nagi Assaad, Michael Kalloniatis
: Fundus autofluorescence (FAF) provides detailed insight into the health of the retinal pigment epithelium (RPE). This is highly valuable in age-related macular degeneration (AMD) as RPE damage is a hallmark of the disease. The purpose of this paper is to critically appraise current clinical descriptions regarding the appearance of AMD using FAF and to integrate these findings into a chair-side reference. A wide variety of FAF patterns have been described in AMD, which is consistent with the clinical heterogeneity of the disease...
September 23, 2016: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/27587715/pilot-evaluation-of-short-term-changes-in-macular-pigment-and-retinal-sensitivity-in-different-phenotypes-of-early-age-related-macular-degeneration-after-carotenoid-supplementation
#9
Federico Corvi, Eric H Souied, Yousra Falfoul, Anouk Georges, Camille Jung, Lea Querques, Giuseppe Querques
PURPOSE: To investigate the response of carotenoid supplementation in different phenotypes of early age-related macular degeneration (AMD) by measuring macular pigment optical density (MPOD) and retinal sensitivity. METHODS: Consecutive patients with only medium/large drusen and only reticular pseudodrusen (RPD) and age-matched and sex-matched controls were enrolled. At baseline, participants underwent a complete ophthalmological examination including measurement of best-corrected visual acuity (BCVA), MPOD and retinal sensitivity...
September 1, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27417506/macular-atrophy-in-patients-with-long-term-anti-vegf-treatment-for-neovascular-age-related-macular-degeneration
#10
Marion R Munk, Lala Ceklic, Andreas Ebneter, Wolfgang Huf, Sebastian Wolf, Martin S Zinkernagel
PURPOSE: To identify the prevalence and progression of macular atrophy (MA) in neovascular age-related macular degeneration (AMD) patients under long-term anti-vascular endothelial growth factor (VEGF) therapy and to determine risk factors. METHOD: This retrospective study included patients with neovascular AMD and ≥30 anti-VEGF injections. Macular atrophy (MA) was measured using near infrared and spectral-domain optical coherence tomography (SD-OCT). Yearly growth rate was estimated using square-root transformation to adjust for baseline area and allow for linearization of growth rate...
December 2016: Acta Ophthalmologica
https://www.readbyqxmd.com/read/27404384/clinical-application-of-multicolor-imaging-technology
#11
Anna C S Tan, Monika Fleckenstein, Steffen Schmitz-Valckenberg, Frank G Holz
PURPOSE: To assess the clinical application of multicolor imaging by confocal scanning laser ophthalmoscopy (cSLO). METHODS: Retinal imaging was performed in 76 patients including cSLO multicolor imaging (SPECTRALIS SD-OCT, Heidelberg Engineering, Heidelberg, Germany) and color fundus photography (CFP). RESULTS: The use of confocal optics, reduced light scatter and automated eye tracking enable high-resolution cSLO reflectance images. Compared to CFP, the appearance of pigment alterations and hemorrhages were some of the differences observed...
2016: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/27388725/longitudinal-structural-changes-in-late-onset-retinal-degeneration
#12
Catherine Cukras, Jason Flamendorf, Wai T Wong, Radha Ayyagari, Denise Cunningham, Paul A Sieving
PURPOSE: To characterize longitudinal structural changes in early stages of late-onset retinal degeneration to investigate pathogenic mechanisms. METHODS: Two affected siblings, both with a S163R missense mutation in the causative gene C1QTNF5, were followed for 8+ years. Color fundus photos, fundus autofluorescence images, near-infrared reflectance fundus images, and spectral domain optical coherence tomography scans were acquired during follow-up. RESULTS: Both patients, aged 45 and 50 years, had good visual acuities (>20/20) in the context of prolonged dark adaptation...
December 2016: Retina
https://www.readbyqxmd.com/read/27380430/reticular-pseudodrusen-are-not-a-predictive-factor-for-the-1-year-response-to-intravitreal-ranibizumab-in-neovascular-age-related-macular-degeneration
#13
Sylvia Nghiem-Buffet, Audrey Giocanti-Auregan, Camille Jung, Lise Dubois, Pauline Dourmad, Lea Galbadon, Franck Fajnkuchen, Gabriel Quentel, Salomon Y Cohen
PURPOSE: To investigate reticular pseudodrusen (RPD) as a potential baseline factor predictive of a poor 1-year response to intravitreal ranibizumab in eyes with neovascular age-related macular degeneration. METHODS: Retrospective, monocentric case series including 98 consecutive naive neovascular age-related macular degeneration patients. Presence of RPD was assessed by two graders based on color, blue-light, fundus autofluorescence pictures, and spectral-domain optical coherence tomography...
July 1, 2016: Retina
https://www.readbyqxmd.com/read/27367499/frequency-phenotypic-characteristics-and-progression-of-atrophy-associated-with-a-diseased-bruch-s-membrane-in-pseudoxanthoma-elasticum
#14
Martin Gliem, Philipp L Müller, Johannes Birtel, Doris Hendig, Frank G Holz, Peter Charbel Issa
PURPOSE: To characterize atrophy of the outer retina and the retinal pigment epithelium in patients with pseudoxanthoma elasticum (PXE). METHODS: In this retrospective cross-sectional study, the frequency and phenotypic characteristics of manifest atrophy were investigated in 276 eyes of 139 patients using color fundus photography, fundus autofluorescence (AF) imaging, and spectral domain optical coherence tomography. Progression rates of atrophy were quantified in eyes with longitudinal AF recordings...
June 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27367498/multimodal-imaging-of-reticular-pseudodrusen-in-a-population-based-setting-the-alienor-study
#15
Hélène Chan, Audrey Cougnard-Grégoire, Marie-Noëlle Delyfer, France Combillet, Marie-Bénédicte Rougier, Cédric Schweitzer, Jean-François Dartigues, Jean-François Korobelnik, Cécile Delcourt
PURPOSE: To document reticular pseudodrusen (RPD) using multimodal imaging in French elderly subjects. METHODS: A total of 494 subjects (970 eyes) aged 77 years or more, from the Alienor study, were examined in 2011 and 2012. Reticular pseudodrusen were defined as definite if they were present with at least two imaging methods among color retinal photographs, macular cube (20° × 15°) of spectral-domain optical coherence tomography (SD-OCT), fundus autofluorescence (FAF), and infrared reflectance (IR)...
June 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27262765/fully-automated-prediction-of-geographic-atrophy-growth-using-quantitative-spectral-domain-optical-coherence-tomography-biomarkers
#16
Sijie Niu, Luis de Sisternes, Qiang Chen, Daniel L Rubin, Theodore Leng
PURPOSE: To develop a predictive model based on quantitative characteristics of geographic atrophy (GA) to estimate future potential regions of GA growth. DESIGN: Progression study and predictive model. PARTICIPANTS: One hundred eighteen spectral-domain (SD) optical coherence tomography (OCT) scans of 38 eyes in 29 patients. METHODS: Imaging features of GA quantifying its extent and location, as well as characteristics at each topographic location related to individual retinal layer thickness and reflectivity, the presence of pathologic features (like reticular pseudodrusen or loss of photoreceptors), and other known risk factors of GA growth, were extracted automatically from 118 SD OCT scans of 38 eyes from 29 patients collected over a median follow-up of 2...
August 2016: Ophthalmology
https://www.readbyqxmd.com/read/27253610/quantitative-fundus-autofluorescence-in-early-and-intermediate-age-related-macular-degeneration
#17
Martin Gliem, Philipp L Müller, Robert P Finger, Myra B McGuinness, Frank G Holz, Peter Charbel Issa
IMPORTANCE: Increased lipofuscin accumulation is assumed to be an important factor in the pathogenesis of age-related macular degeneration (AMD), although direct evidence for this hypothesis is missing. OBJECTIVE: To quantitatively investigate lipofuscin-associated fundus autofluorescence (AF) in patients with early and intermediate AMD. DESIGN, SETTING, AND PARTICIPANTS: A prospective, single-center, case-control study was conducted from August 1, 2014, to October 31, 2015, at a university referral center...
July 1, 2016: JAMA Ophthalmology
https://www.readbyqxmd.com/read/27213222/factors-predictive-of-visual-outcome-1-year-after-intravitreal-aflibercept-injection-for-typical-neovascular-age-related-macular-degeneration
#18
Wataru Kikushima, Yoichi Sakurada, Atsushi Sugiyama, Naohiko Tanabe, Atsuki Kume, Hiroyuki Iijima
PURPOSE: Several factors have been reported to be associated with visual outcomes after intravitreal ranibizumab treatment for neovascular age-related macular degeneration (AMD). In the present study, we investigated the factors associated with visual outcomes after intravitreal aflibercept injection (IAI) for typical neovascular AMD. METHODS: We retrospectively studied the visual changes in 47 eyes of 51 patients with typical neovascular AMD, who had been initially treated with 3 monthly IAI followed by as-needed IAI...
July 2016: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27193430/exploring-choriocapillaris-under-reticular-pseudodrusen-using-oct-angiography
#19
Florian Alten, Peter Heiduschka, Christoph R Clemens, Nicole Eter
PURPOSE: To evaluate if choriocapillaris (CC) vessel density and CC decorrelation signal index are compromised in eyes with reticular pseudodrusen (RPD) using optical coherence tomography angiography (OCT-A). METHODS: Decorrelation values in OCT-A CC images of 20 RPD patients were measured in the outer superior and the outer inferior sector of the EDTRS grid and compared to age-matched healthy controls. CC vessel density and CC decorrelation signal index were measured within a 30 μm and a 10 μm OCT-A CC slab...
May 18, 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/27190128/choroidal-structure-in-eyes-with-drusen-and-reticular-pseudodrusen-determined-by-binarisation-of-optical-coherence-tomographic-images
#20
Federico Corvi, Eric H Souied, Vittorio Capuano, Eliana Costanzo, Lucia Benatti, Lea Querques, Francesco Bandello, Giuseppe Querques
PURPOSE: To compare luminal and stromal area of the choroid in eyes with drusen and reticular pseudodrusen (RPD) and to investigate their changes over 24 months. METHODS: In eyes with drusen and RPD and control subjects, total choroidal, luminal and stromal area were measured on optical coherence tomography B-scans converted to binary images, at baseline and after 24 months. RESULTS: Eighteen eyes of 18 subjects for each group were included...
May 17, 2016: British Journal of Ophthalmology
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