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Reticular Pseudodrusen

Gabriëlle H S Buitendijk, Ada J Hooghart, Corina Brussee, Paulus T V M de Jong, Albert Hofman, Johannes R Vingerling, Caroline C W Klaver
Purpose: Reticular pseudodrusen (RPD) are considered to be a distinct feature in AMD. Population studies have studied the epidemiology of RPD using standard color fundus photographs (CFP). However, recent studies have shown that RPD are better imaged using near-infrared (NIR) imaging. We studied the epidemiology of RPD in a large population-based study using NIR and CFP. Methods: Participants aged 65+ years from the Rotterdam Study underwent ophthalmologic examination including NIR and CFP...
October 1, 2016: Investigative Ophthalmology & Visual Science
J Q Gil, J P Marques, R Hogg, C Rosina, M L Cachulo, A Santos, G Staurenghi, U Chakravarthy, R Silva
PurposeTo determine whether reticular pseudodrusen (RPD) confer a long-term increased risk of progression to late age-related macular degeneration (AMD) in the fellow eye of patients with unilateral wet-AMD.Patients and methodsThis was a multicenter, combined prospective and retrospective, longitudinal, observational, study. Patients with wet-AMD in one eye were recruited from two centers and evaluated on the risk of progression to late-AMD in the second eye (study eye). A minimum follow-up of 5 years was required, unless progression occurred first...
October 21, 2016: Eye
Rogan G Fraser, Rose Tan, Lauren N Ayton, Emily Caruso, Robyn H Guymer, Chi D Luu
Purpose: We determine the feasibility of using a dark-adapted chromatic (DAC) perimeter to obtain dark-adapted static and dynamic rod function at multiple retinal locations, and compare these functional parameters between subjects with intermediate age-related macular degeneration (AMD) and normal controls. Methods: Perimetric dark-adapted retinal sensitivities for the 505 and 620 nm stimuli across 7 retinal locations within the central 12° were repeatedly measured after exposing to a single photobleach in 22 intermediate AMD subjects and 8 controls...
October 1, 2016: Investigative Ophthalmology & Visual Science
Angelica Ly, Lisa Nivison-Smith, Nagi Assaad, Michael Kalloniatis
: Fundus autofluorescence (FAF) provides detailed insight into the health of the retinal pigment epithelium (RPE). This is highly valuable in age-related macular degeneration (AMD) as RPE damage is a hallmark of the disease. The purpose of this paper is to critically appraise current clinical descriptions regarding the appearance of AMD using FAF and to integrate these findings into a chair-side reference. A wide variety of FAF patterns have been described in AMD, which is consistent with the clinical heterogeneity of the disease...
September 23, 2016: Optometry and Vision Science: Official Publication of the American Academy of Optometry
Federico Corvi, Eric H Souied, Yousra Falfoul, Anouk Georges, Camille Jung, Lea Querques, Giuseppe Querques
PURPOSE: To investigate the response of carotenoid supplementation in different phenotypes of early age-related macular degeneration (AMD) by measuring macular pigment optical density (MPOD) and retinal sensitivity. METHODS: Consecutive patients with only medium/large drusen and only reticular pseudodrusen (RPD) and age-matched and sex-matched controls were enrolled. At baseline, participants underwent a complete ophthalmological examination including measurement of best-corrected visual acuity (BCVA), MPOD and retinal sensitivity...
September 1, 2016: British Journal of Ophthalmology
Marion R Munk, Lala Ceklic, Andreas Ebneter, Wolfgang Huf, Sebastian Wolf, Martin S Zinkernagel
PURPOSE: To identify the prevalence and progression of macular atrophy (MA) in neovascular age-related macular degeneration (AMD) patients under long-term anti-vascular endothelial growth factor (VEGF) therapy and to determine risk factors. METHOD: This retrospective study included patients with neovascular AMD and ≥30 anti-VEGF injections. Macular atrophy (MA) was measured using near infrared and spectral-domain optical coherence tomography (SD-OCT). Yearly growth rate was estimated using square-root transformation to adjust for baseline area and allow for linearization of growth rate...
July 15, 2016: Acta Ophthalmologica
Anna C S Tan, Monika Fleckenstein, Steffen Schmitz-Valckenberg, Frank G Holz
PURPOSE: To assess the clinical application of multicolor imaging by confocal scanning laser ophthalmoscopy (cSLO). METHODS: Retinal imaging was performed in 76 patients including cSLO multicolor imaging (SPECTRALIS SD-OCT, Heidelberg Engineering, Heidelberg, Germany) and color fundus photography (CFP). RESULTS: The use of confocal optics, reduced light scatter and automated eye tracking enable high-resolution cSLO reflectance images. Compared to CFP, the appearance of pigment alterations and hemorrhages were some of the differences observed...
2016: Ophthalmologica. Journal International D'ophtalmologie
Catherine Cukras, Jason Flamendorf, Wai T Wong, Radha Ayyagari, Denise Cunningham, Paul A Sieving
PURPOSE: To characterize longitudinal structural changes in early stages of late-onset retinal degeneration to investigate pathogenic mechanisms. METHODS: Two affected siblings, both with a S163R missense mutation in the causative gene C1QTNF5, were followed for 8+ years. Color fundus photos, fundus autofluorescence images, near-infrared reflectance fundus images, and spectral domain optical coherence tomography scans were acquired during follow-up. RESULTS: Both patients, aged 45 and 50 years, had good visual acuities (>20/20) in the context of prolonged dark adaptation...
July 6, 2016: Retina
Sylvia Nghiem-Buffet, Audrey Giocanti-Auregan, Camille Jung, Lise Dubois, Pauline Dourmad, Lea Galbadon, Franck Fajnkuchen, Gabriel Quentel, Salomon Y Cohen
PURPOSE: To investigate reticular pseudodrusen (RPD) as a potential baseline factor predictive of a poor 1-year response to intravitreal ranibizumab in eyes with neovascular age-related macular degeneration. METHODS: Retrospective, monocentric case series including 98 consecutive naive neovascular age-related macular degeneration patients. Presence of RPD was assessed by two graders based on color, blue-light, fundus autofluorescence pictures, and spectral-domain optical coherence tomography...
July 1, 2016: Retina
Martin Gliem, Philipp L Müller, Johannes Birtel, Doris Hendig, Frank G Holz, Peter Charbel Issa
PURPOSE: To characterize atrophy of the outer retina and the retinal pigment epithelium in patients with pseudoxanthoma elasticum (PXE). METHODS: In this retrospective cross-sectional study, the frequency and phenotypic characteristics of manifest atrophy were investigated in 276 eyes of 139 patients using color fundus photography, fundus autofluorescence (AF) imaging, and spectral domain optical coherence tomography. Progression rates of atrophy were quantified in eyes with longitudinal AF recordings...
June 1, 2016: Investigative Ophthalmology & Visual Science
Hélène Chan, Audrey Cougnard-Grégoire, Marie-Noëlle Delyfer, France Combillet, Marie-Bénédicte Rougier, Cédric Schweitzer, Jean-François Dartigues, Jean-François Korobelnik, Cécile Delcourt
PURPOSE: To document reticular pseudodrusen (RPD) using multimodal imaging in French elderly subjects. METHODS: A total of 494 subjects (970 eyes) aged 77 years or more, from the Alienor study, were examined in 2011 and 2012. Reticular pseudodrusen were defined as definite if they were present with at least two imaging methods among color retinal photographs, macular cube (20° × 15°) of spectral-domain optical coherence tomography (SD-OCT), fundus autofluorescence (FAF), and infrared reflectance (IR)...
June 1, 2016: Investigative Ophthalmology & Visual Science
Sijie Niu, Luis de Sisternes, Qiang Chen, Daniel L Rubin, Theodore Leng
PURPOSE: To develop a predictive model based on quantitative characteristics of geographic atrophy (GA) to estimate future potential regions of GA growth. DESIGN: Progression study and predictive model. PARTICIPANTS: One hundred eighteen spectral-domain (SD) optical coherence tomography (OCT) scans of 38 eyes in 29 patients. METHODS: Imaging features of GA quantifying its extent and location, as well as characteristics at each topographic location related to individual retinal layer thickness and reflectivity, the presence of pathologic features (like reticular pseudodrusen or loss of photoreceptors), and other known risk factors of GA growth, were extracted automatically from 118 SD OCT scans of 38 eyes from 29 patients collected over a median follow-up of 2...
August 2016: Ophthalmology
Martin Gliem, Philipp L Müller, Robert P Finger, Myra B McGuinness, Frank G Holz, Peter Charbel Issa
IMPORTANCE: Increased lipofuscin accumulation is assumed to be an important factor in the pathogenesis of age-related macular degeneration (AMD), although direct evidence for this hypothesis is missing. OBJECTIVE: To quantitatively investigate lipofuscin-associated fundus autofluorescence (AF) in patients with early and intermediate AMD. DESIGN, SETTING, AND PARTICIPANTS: A prospective, single-center, case-control study was conducted from August 1, 2014, to October 31, 2015, at a university referral center...
July 1, 2016: JAMA Ophthalmology
Wataru Kikushima, Yoichi Sakurada, Atsushi Sugiyama, Naohiko Tanabe, Atsuki Kume, Hiroyuki Iijima
PURPOSE: Several factors have been reported to be associated with visual outcomes after intravitreal ranibizumab treatment for neovascular age-related macular degeneration (AMD). In the present study, we investigated the factors associated with visual outcomes after intravitreal aflibercept injection (IAI) for typical neovascular AMD. METHODS: We retrospectively studied the visual changes in 47 eyes of 51 patients with typical neovascular AMD, who had been initially treated with 3 monthly IAI followed by as-needed IAI...
July 2016: Journal of Ocular Pharmacology and Therapeutics
Florian Alten, Peter Heiduschka, Christoph R Clemens, Nicole Eter
PURPOSE: To evaluate if choriocapillaris (CC) vessel density and CC decorrelation signal index are compromised in eyes with reticular pseudodrusen (RPD) using optical coherence tomography angiography (OCT-A). METHODS: Decorrelation values in OCT-A CC images of 20 RPD patients were measured in the outer superior and the outer inferior sector of the EDTRS grid and compared to age-matched healthy controls. CC vessel density and CC decorrelation signal index were measured within a 30 μm and a 10 μm OCT-A CC slab...
May 18, 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
Federico Corvi, Eric H Souied, Vittorio Capuano, Eliana Costanzo, Lucia Benatti, Lea Querques, Francesco Bandello, Giuseppe Querques
PURPOSE: To compare luminal and stromal area of the choroid in eyes with drusen and reticular pseudodrusen (RPD) and to investigate their changes over 24 months. METHODS: In eyes with drusen and RPD and control subjects, total choroidal, luminal and stromal area were measured on optical coherence tomography B-scans converted to binary images, at baseline and after 24 months. RESULTS: Eighteen eyes of 18 subjects for each group were included...
May 17, 2016: British Journal of Ophthalmology
Kamron N Khan, Omar A Mahroo, Rehna S Khan, Moin D Mohamed, Martin McKibbin, Alan Bird, Michel Michaelides, Adnan Tufail, Anthony T Moore
Drusen are discussed frequently in the context of their association with age-related macular degeneration (AMD). Some types may, however, be regarded as a normal consequence of ageing; others may be observed in young age groups. They also occur in a number of inherited disorders and some systemic conditions. Whilst drusen are classically located external (sclerad) to the retinal pigment epithelium, accumulations of material internal (vitread to) this layer can display a drusen-like appearance, having been variously termed pseudodrusen or subretinal drusenoid deposits...
July 2016: Progress in Retinal and Eye Research
Nagahisa Yoshimura
Age-related macular degeneration (AMD) in the Japanese often shows different clinical features from those described in Caucasians. For example, we often observe choroidal neovascularization (CNV) in elderly patients without drusen in the fundus. The high incidence of polypoidal choroidal vasculopathy (PCV) in AMD among Japanese is well-known. The reason why such differences occur in clinical manifestations of AMD has been one of my main interests. In this review article, I will discuss the characteristics of AMD in the Japanese population, as found in our recent study...
March 2016: Nippon Ganka Gakkai Zasshi
Geoff K Frampton, Neelam Kalita, Liz Payne, Jill Colquitt, Emma Loveman
BACKGROUND: Natural fluorescence in the eye may be increased or decreased by diseases that affect the retina. Imaging methods based on confocal scanning laser ophthalmoscopy (cSLO) can detect this 'fundus autofluorescence' (FAF) by illuminating the retina using a specific light 'excitation wavelength'. FAF imaging could assist the diagnosis or monitoring of retinal conditions. However, the accuracy of the method for diagnosis or monitoring is unclear. OBJECTIVE: To conduct a systematic review to determine the accuracy of FAF imaging using cSLO for the diagnosis or monitoring of retinal conditions, including monitoring of response to therapy...
April 2016: Health Technology Assessment: HTA
Angelica Ly, Lisa Nivison-Smith, Nagi Assaad, Michael Kalloniatis
PURPOSE: The purpose of this article is to describe the appearance of age-related macular degeneration (AMD) phenotypes using infrared (IR) reflectance imaging. IR reflectance imaging of the retina has the potential to highlight specific sub-retinal features and pathology. However, its role in macular disease, specifically AMD, is often underestimated and requires clarification. RECENT FINDINGS: Recent advances in clinical methods, imaging and scientific knowledge may be integrated to improve the accuracy of disease stratification in AMD...
May 2016: Ophthalmic & Physiological Optics: the Journal of the British College of Ophthalmic Opticians (Optometrists)
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