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Reticular Pseudodrusen

Craig Wilde, Ali Poostchi, Rajnikant L Mehta, Jonathan G Hillman, Hamish K MacNab, Marco Messina, Marco Morales, Stephen A Vernon, Winfried M Amoaku
AIMS: To determine prevalence, associations, and risk factors for reticular pseudodrusen (RPD) in a UK population. METHODS: Cross-sectional study of Bridlington residents aged ≥65 years. Masked grading of colour fundus photographs from 3549 participants. RPD presence, phenotype, and topography were recorded, demographic details were analysed, and prevalence was calculated. RESULTS: RPD was detected in 281 eyes (176 individuals) of 3476 participants (5...
March 1, 2018: Eye
Irmela Mantel, Ali Dirani, Marta Zola, Parmis Parvin, Sophie De Massougnes, Ciara Bergin
PURPOSE: To investigate factors associated with macular atrophy (MA) incidence in neovascular age-related macular degeneration treated with either ranibizumab or aflibercept in an Observe-and-Plan variable dosing regimen. METHODS: Information was obtained from two identical prospective treatment protocols using ranibizumab or aflibercept in a variable dosing regimen termed "Observe and Plan." Eyes without MA at baseline were included. New atrophy at the final 2-year visit was investigated with univariate and multivariate analysis to identify associated risk factors, focusing on treatment factors...
January 23, 2018: Retina
Maria Vittoria Cicinelli, Alessandro Rabiolo, Riccardo Sacconi, Francesca Lamanna, Lea Querques, Francesco Bandello, Giuseppe Querques
PURPOSE: To investigate the intraretinal structural and vascular alterations in patients featuring reticular pseudodrusen (RPD), RPD with outer retinal atrophy (ORA), and drusen. DESIGN: Observational cross-sectional study. METHODS: Clinical practice study including 68 eyes of 57 patients (22 eyes of 17 patients with RPD; 24 eyes of 21 patients with RPD+ORA; 22 eyes of 19 patients with drusen). Each patient underwent spectral-domain optical coherence tomography (OCT) and OCT angiography (OCT-A)...
January 23, 2018: British Journal of Ophthalmology
Pedro Camacho, Marco Dutra-Medeiros, Diogo Cabral, Rufino Silva
PURPOSE: To evaluate outer retina and choroidal thickness in subjects with intermediate age-related macular degeneration (iAMD) and to describe associations with the presence of reticular pseudodrusen (RPD). METHODS: This was a retrospective, cross-sectional analysis of 157 consecutive eyes (specifically: 62 eyes classified as having RPD and 95 eyes with drusen ≥125 µm). Only cases with digital color fundus photographs, red-free, and infrared, obtained and graded according to the Age-Related Eye Disease Study to define iAMD, were used for this study...
December 14, 2017: Ophthalmic Research
Chi Yd Ho, Jia J Lek, Khin Z Aung, Myra B McGuinness, Chi D Luu, Robyn H Guymer
IMPORTANCE: Reticular pseudodrusen (RPD) is strongly associated with late age-related macular degeneration (AMD) but their aetiology remains unknown. RPD have been associated with reduced choroidal thickness (ChT) but most studies are limited by small sample size and varying severity of AMD. BACKGROUND: To investigate the relationship between choroidal thickness and RPD in eyes with intermediate AMD (iAMD), controlling for variables known to influence ChT. DESIGN: Retrospective cohort study...
December 13, 2017: Clinical & Experimental Ophthalmology
Janet R Sparrow, Maarjallis Paavo
No abstract text is available yet for this article.
December 1, 2017: Investigative Ophthalmology & Visual Science
Riccardo Sacconi, Giuseppe Querques
No abstract text is available yet for this article.
December 1, 2017: Investigative Ophthalmology & Visual Science
Martin Gliem, Philipp L Müller, Johannes Birtel, Myra B McGuinness, Robert P Finger, Philipp Herrmann, Doris Hendig, Frank G Holz, Peter Charbel Issa
Purpose: To quantify lipofuscin-associated fundus autofluorescence in patients with pseudoxanthoma elasticum (PXE), a model disease for Bruch's membrane pathology. Methods: In this prospective, monocenter, cross-sectional case-control study, 49 patients with PXE (mean age: 46 years, range 18-62) underwent quantitative fundus autofluorescence (qAF) imaging with a modified scanning laser ophthalmoscope containing an internal fluorescent reference for normalization of images...
December 1, 2017: Investigative Ophthalmology & Visual Science
Giuseppe Querques, Maria Vittoria Cicinelli, Alessandro Rabiolo, Luigi de Vitis, Riccardo Sacconi, Lea Querques, Francesco Bandello
PURPOSE: To give an updated review of laser approaches to non-exudative age-related macular degeneration (AMD). METHODS: PubMed and Medline database searches were carried out using the terms "laser" and "photocoagulation" associated with "age-related macular degeneration", and latest publications up to May 2017 have been reviewed. Moreover, the design of an ongoing single-center, non-randomized, phase I-II, pilot study, the PASCAL-GA trial, coordinated by F...
January 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
Timothy W Olsen, Albert Liao, Hershonna S Robinson, Neal V Palejwala, Nicholas Sprehe
Purpose: To refine the Minnesota Grading System (MGS) using definitions from the Age-Related Eye Disease Studies (AREDS) into a nine-step grading scale (MGS-9). Methods: A nine-step grading scale descriptive analysis using three key phenotypic features (total drusen area, increased, and decreased pigmentation) of human eyebank eyes that were graded according to definitions from the AREDS criteria in order to harmonize studies of disease progression for research involving human tissue...
October 1, 2017: Investigative Ophthalmology & Visual Science
Alessandro Rabiolo, Riccardo Sacconi, Maria Vittoria Cicinelli, Lea Querques, Francesco Bandello, Giuseppe Querques
Age-related macular degeneration (AMD) is a leading cause of vision loss in patients >50 years old. The hallmark of the disease is represented by the accumulation of extracellular material between retinal pigment epithelium and the inner collagenous layer of Bruch's membrane, called drusen. Although identified almost 30 years ago, reticular pseudodrusen (RPD) have been recently recognized as a distinctive phenotype. Unlike drusen, they are located in the subretinal space. RPD are strongly associated with late AMD, especially geographic atrophy, type 2 and 3 choroidal neovascularization, which, in turn, are less common in typical AMD...
2017: Clinical Ophthalmology
Chantal Dysli, Rahel Fink, Sebastian Wolf, Martin S Zinkernagel
Purpose: The purpose of this study was to characterize fundus autofluorescence lifetimes of retinal drusen in patients with AMD. Methods: Patients with AMD and retinal drusen and healthy controls of similar age were examined. A fluorescence lifetime imaging ophthalmoscope was used. Retinal autofluorescence was excited using a 473-nm pulsed laser, and fundus autofluorescence lifetimes of the central retina (30°) were measured in two distinct spectral channels (short: 498 to 560 nm [SSC]; long: 560 to 720 nm [LSC])...
September 1, 2017: Investigative Ophthalmology & Visual Science
Maarjaliis Paavo, Winston Lee, John Merriam, Srilaxmi Bearelly, Stephen Tsang, Stanley Chang, Janet R Sparrow
Purpose: We sought to determine whether information revealed from the reflectance, autofluorescence, and absorption properties of RPE cells situated posterior to reticular pseudodrusen (RPD) could provide insight into the origins and structure of RPD. Methods: RPD were studied qualitatively by near-infrared fundus autofluorescence (NIR-AF), short-wavelength fundus autofluorescence (SW-AF), and infrared reflectance (IR-R) images, and the presentation was compared to horizontal and en face spectral domain optical coherence tomographic (SD-OCT) images...
September 1, 2017: Investigative Ophthalmology & Visual Science
Stephen James Talks, Akhunzada Muhammad Aftab, Imran Ashfaq, Taha Soomro
The use of imaging for age-related macular degeneration (AMD) depends on how it benefits clinical management and on reimbursement. The latter should relate to the former. This review assesses how different forms of AMD can be imaged and what information this provides. For nonneovascular AMD high-resolution optical coherence tomography (OCT), autofluorescence, and near infrared imaging can identify the type of drusen, such as reticular pseudodrusen, which influences prognosis, and the amount of atrophy, for which phase 3 trials are underway...
November 2017: Asia-Pacific Journal of Ophthalmology
Roopa Vemala, Sobha Sivaprasad, John L Barbur
Purpose: To evaluate chromatic sensitivity in patients with age-related macular degeneration (AMD) characterized by drusen and reticular pseudodrusen. To investigate whether the severity of color vision loss can distinguish between various stages of AMD and hence be used as an index of progression toward advanced AMD. Methods: Chromatic sensitivity was measured by using the Color Assessment and Diagnosis (CAD) test in asymptomatic individuals with early and intermediate AMD and compared to normative data...
May 1, 2017: Investigative Ophthalmology & Visual Science
Katie W Graham, Usha Chakravarthy, Ruth E Hogg, K Alyson Muldrew, Ian S Young, Frank Kee
PURPOSE: To compare multicolor (MC) and traditional color fundus photography (CFP) in their ability to detect features of early and late age-related macular degeneration (AMD). METHODS: Study design: Observational case series. PARTICIPANTS: fundus images captured using standard CFP and MC imaging from 33 patients attending hospital clinics and 26 participants from the pilot phase of the Northern Ireland Cohort for the Longitudinal Study of Ageing (NICOLA)...
August 22, 2017: Retina
Rachel V McCarter, Gareth J McKay, Nicola B Quinn, Usha Chakravarthy, Tom J MacGillivray, Gavin Robertson, Enrico Pellegrini, Emanuele Trucco, Michelle C Williams, Tunde Peto, Baljean Dhillon, Edwin Jr van Beek, David E Newby, Frank Kee, Ian S Young, Ruth E Hogg
PURPOSE: Reticular pseudodrusen (RPD) are a risk factor for late age-related macular degeneration (AMD). Associations between RPD and coronary artery disease (CAD) have been reported from small case-control studies. This study investigated the association of RPD within a predominantly CAD cohort. METHODS: A subgroup of subjects from a multicentre randomised controlled trial of CT coronary angiography (CTCA) underwent ultrawide field (UWF) retinal imaging CAD determined by CTCA and was categorised as normal, non-obstructive or obstructive...
August 19, 2017: British Journal of Ophthalmology
M B McGuinness, R P Finger, A Karahalios, R H Guymer, D R English, E W Chong, A M Hodge, L D Robman, G G Giles, J A Simpson
AimsTo assess associations between features of age-related macular degeneration (AMD) and mortality.MethodsA total of 21 129 participants from the Melbourne Collaborative Cohort Study aged 47-85 years (60% female) were assessed for AMD (2003-2007). Mortality data to December 31, 2012 were obtained through linkage with the National Death Index. Associations were assessed using Cox regression, adjusting for age, sex, smoking, region of birth, education, physical activity, diet and alcohol.ResultsLate AMD was identified in 122 (0...
September 2017: Eye
Jordi Monés, Marc Biarnés
BACKGROUND/AIMS: To identify ocular phenotypes in patients with geographic atrophy secondary to age-related macular degeneration (GA) using a data-driven cluster analysis. METHODS: This was a retrospective analysis of data from a prospective, natural history study of patients with GA who were followed for ≥6 months. Cluster analysis was used to identify subgroups within the population based on the presence of several phenotypic features: soft drusen, reticular pseudodrusen (RPD), primary foveal atrophy, increased fundus autofluorescence (FAF), greyish FAF appearance and subfoveal choroidal thickness (SFCT)...
July 20, 2017: British Journal of Ophthalmology
Maria Vittoria Cicinelli, Alessandro Rabiolo, Riccardo Sacconi, Adriano Carnevali, Lea Querques, Francesco Bandello, Giuseppe Querques
Optical coherence tomography angiography (OCT-A) is a new imaging modality that provides non-invasive characterization and quantification of the microvasculature in different retinal conditions. The purpose of this paper is to give an updated review of the features of dry age-related macular degeneration investigated by means of new generation OCT-A. We searched PubMed and Medline using the terms "optical coherence tomography angiography" associated with "age-related macular degeneration", "drusen", "reticular pseudodrusen," and "geographic atrophy" and reviewed publications up to January, 2017...
June 22, 2017: Survey of Ophthalmology
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