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Reticular Pseudodrusen

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https://www.readbyqxmd.com/read/29075760/the-nine-step-minnesota-grading-system-for-eyebank-eyes-with-age-related-macular-degeneration-a-systematic-approach-to-study-disease-stages
#1
Timothy W Olsen, Albert Liao, Hershonna S Robinson, Neal V Palejwala, Nicholas Sprehe
Purpose: To refine the Minnesota Grading System (MGS) using definitions from the Age-Related Eye Disease Studies (AREDS) into a nine-step grading scale (MGS-9). Methods: A nine-step grading scale descriptive analysis using three key phenotypic features (total drusen area, increased, and decreased pigmentation) of human eyebank eyes that were graded according to definitions from the AREDS criteria in order to harmonize studies of disease progression for research involving human tissue...
October 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29033536/spotlight-on-reticular-pseudodrusen
#2
REVIEW
Alessandro Rabiolo, Riccardo Sacconi, Maria Vittoria Cicinelli, Lea Querques, Francesco Bandello, Giuseppe Querques
Age-related macular degeneration (AMD) is a leading cause of vision loss in patients >50 years old. The hallmark of the disease is represented by the accumulation of extracellular material between retinal pigment epithelium and the inner collagenous layer of Bruch's membrane, called drusen. Although identified almost 30 years ago, reticular pseudodrusen (RPD) have been recently recognized as a distinctive phenotype. Unlike drusen, they are located in the subretinal space. RPD are strongly associated with late AMD, especially geographic atrophy, type 2 and 3 choroidal neovascularization, which, in turn, are less common in typical AMD...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28973332/fluorescence-lifetimes-of-drusen-in-age-related-macular-degeneration
#3
Chantal Dysli, Rahel Fink, Sebastian Wolf, Martin S Zinkernagel
Purpose: The purpose of this study was to characterize fundus autofluorescence lifetimes of retinal drusen in patients with AMD. Methods: Patients with AMD and retinal drusen and healthy controls of similar age were examined. A fluorescence lifetime imaging ophthalmoscope was used. Retinal autofluorescence was excited using a 473-nm pulsed laser, and fundus autofluorescence lifetimes of the central retina (30°) were measured in two distinct spectral channels (short: 498 to 560 nm [SSC]; long: 560 to 720 nm [LSC])...
September 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28973322/intraretinal-correlates-of-reticular-pseudodrusen-revealed-by-autofluorescence-and-en-face-oct
#4
Maarjaliis Paavo, Winston Lee, John Merriam, Srilaxmi Bearelly, Stephen Tsang, Stanley Chang, Janet R Sparrow
Purpose: We sought to determine whether information revealed from the reflectance, autofluorescence, and absorption properties of RPE cells situated posterior to reticular pseudodrusen (RPD) could provide insight into the origins and structure of RPD. Methods: RPD were studied qualitatively by near-infrared fundus autofluorescence (NIR-AF), short-wavelength fundus autofluorescence (SW-AF), and infrared reflectance (IR-R) images, and the presentation was compared to horizontal and en face spectral domain optical coherence tomographic (SD-OCT) images...
September 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28905541/the-role-of-new-imaging-methods-in-managing-age-related-macular-degeneration
#5
Stephen James Talks, Akhunzada Muhammad Aftab, Imran Ashfaq, Taha Soomro
The use of imaging for age-related macular degeneration (AMD) depends on how it benefits clinical management and on reimbursement. The latter should relate to the former. This review assesses how different forms of AMD can be imaged and what information this provides. For nonneovascular AMD high-resolution optical coherence tomography (OCT), autofluorescence, and near infrared imaging can identify the type of drusen, such as reticular pseudodrusen, which influences prognosis, and the amount of atrophy, for which phase 3 trials are underway...
September 14, 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28846119/detection-of-early-loss-of-color-vision-in-age-related-macular-degeneration-with-emphasis-on-drusen-and-reticular-pseudodrusen
#6
Roopa Vemala, Sobha Sivaprasad, John L Barbur
Purpose: To evaluate chromatic sensitivity in patients with age-related macular degeneration (AMD) characterized by drusen and reticular pseudodrusen. To investigate whether the severity of color vision loss can distinguish between various stages of AMD and hence be used as an index of progression toward advanced AMD. Methods: Chromatic sensitivity was measured by using the Color Assessment and Diagnosis (CAD) test in asymptomatic individuals with early and intermediate AMD and compared to normative data...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28834946/identifying-features-of-early-and-late-age-related-macular-degeneration-a-comparison-of-multicolor-versus-traditional-color-fundus-photography
#7
Katie W Graham, Usha Chakravarthy, Ruth E Hogg, K Alyson Muldrew, Ian S Young, Frank Kee
PURPOSE: To compare multicolor (MC) and traditional color fundus photography (CFP) in their ability to detect features of early and late age-related macular degeneration (AMD). METHODS: Study design: Observational case series. PARTICIPANTS: fundus images captured using standard CFP and MC imaging from 33 patients attending hospital clinics and 26 participants from the pilot phase of the Northern Ireland Cohort for the Longitudinal Study of Ageing (NICOLA)...
August 22, 2017: Retina
https://www.readbyqxmd.com/read/28822985/evaluation-of-coronary-artery-disease-as-a-risk-factor-for-reticular-pseudodrusen
#8
Rachel V McCarter, Gareth J McKay, Nicola B Quinn, Usha Chakravarthy, Tom J MacGillivray, Gavin Robertson, Enrico Pellegrini, Emanuele Trucco, Michelle C Williams, Tunde Peto, Baljean Dhillon, Edwin Jr van Beek, David E Newby, Frank Kee, Ian S Young, Ruth E Hogg
PURPOSE: Reticular pseudodrusen (RPD) are a risk factor for late age-related macular degeneration (AMD). Associations between RPD and coronary artery disease (CAD) have been reported from small case-control studies. This study investigated the association of RPD within a predominantly CAD cohort. METHODS: A subgroup of subjects from a multicentre randomised controlled trial of CT coronary angiography (CTCA) underwent ultrawide field (UWF) retinal imaging CAD determined by CTCA and was categorised as normal, non-obstructive or obstructive...
August 19, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28820184/age-related-macular-degeneration-and-mortality-the-melbourne-collaborative-cohort-study
#9
M B McGuinness, R P Finger, A Karahalios, R H Guymer, D R English, E W Chong, A M Hodge, L D Robman, G G Giles, J A Simpson
AimsTo assess associations between features of age-related macular degeneration (AMD) and mortality.MethodsA total of 21 129 participants from the Melbourne Collaborative Cohort Study aged 47-85 years (60% female) were assessed for AMD (2003-2007). Mortality data to December 31, 2012 were obtained through linkage with the National Death Index. Associations were assessed using Cox regression, adjusting for age, sex, smoking, region of birth, education, physical activity, diet and alcohol.ResultsLate AMD was identified in 122 (0...
September 2017: Eye
https://www.readbyqxmd.com/read/28729371/geographic-atrophy-phenotype-identification-by-cluster-analysis
#10
Jordi Monés, Marc Biarnés
BACKGROUND/AIMS: To identify ocular phenotypes in patients with geographic atrophy secondary to age-related macular degeneration (GA) using a data-driven cluster analysis. METHODS: This was a retrospective analysis of data from a prospective, natural history study of patients with GA who were followed for ≥6 months. Cluster analysis was used to identify subgroups within the population based on the presence of several phenotypic features: soft drusen, reticular pseudodrusen (RPD), primary foveal atrophy, increased fundus autofluorescence (FAF), greyish FAF appearance and subfoveal choroidal thickness (SFCT)...
July 20, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28648383/optical-coherence-tomography-angiography-in-dry-age-related-macular-degeneration
#11
REVIEW
Maria Vittoria Cicinelli, Alessandro Rabiolo, Riccardo Sacconi, Adriano Carnevali, Lea Querques, Francesco Bandello, Giuseppe Querques
Optical coherence tomography angiography (OCT-A) is a new imaging modality that provides non-invasive characterization and quantification of the microvasculature in different retinal conditions. The purpose of this paper is to give an updated review of the features of dry age-related macular degeneration investigated by means of new generation OCT-A. We searched PubMed and Medline using the terms "optical coherence tomography angiography" associated with "age-related macular degeneration", "drusen", "reticular pseudodrusen," and "geographic atrophy" and reviewed publications up to January, 2017...
June 22, 2017: Survey of Ophthalmology
https://www.readbyqxmd.com/read/28632734/choroidal-thickness-in-patients-with-coronary-artery-disease
#12
Meleha Ahmad, Patrick A Kaszubski, Lucy Cobbs, Harmony Reynolds, Roland Theodore Smith
PURPOSE: To evaluate choroidal thickness (CTh) in patients with coronary artery disease (CAD) compared to healthy controls. DESIGN: Cross-sectional. METHODS: Setting: Ambulatory clinic of a large city hospital. Patient population: Thirty-four patients had documented CAD, defined as history of >50% obstruction in at least one coronary artery on cardiac catheterization, positive stress test, ST elevation myocardial infarction, or revascularization procedure...
2017: PloS One
https://www.readbyqxmd.com/read/28593728/association-of-risk-genotypes-of-arms2-loc387715-a69s-and-cfh-y402h-with-age-related-macular-degeneration-with-and-without-reticular-pseudodrusen-a-meta-analysis
#13
REVIEW
Mohammad Hossein Jabbarpoor Bonyadi, Mehdi Yaseri, Homayoun Nikkhah, Mortaza Bonyadi, Masoud Soheilian
To pool the results of published data regarding association of ARMS2/LOC387715 A69S, CFH Y402H and CFH I62V genotypes with age-related macular degeneration (AMD) with and without reticular pseudodrusen (RPD). The results of this pooled data used to estimate the contribution of each of these genes in the pathogenesis of RPD. Heterogeneity of studies was evaluated using Cochran Q-test and I(2) index. To modify the heterogeneity in the variables, we used the random effects model. Meta-analysis was performed using STATA...
June 8, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28564702/associations-between-%C3%AE-peripapillary-atrophy-and-reticular-pseudodrusen-in-early-age-related-macular-degeneration
#14
Aakriti Garg, Dana M Blumberg, Lama A Al-Aswad, Maris Oll, Suzanne Yzer, Max Forbes, Rando L Allikmets, Srilaxmi Bearelly
Purpose: Choroidal thinning has been associated with reticular pseudodrusen (RPD) and β-peripapillary atrophy (β-PPA), which have been linked to normal-tension glaucoma (NTG). This analysis sought to determine whether RPD are independently associated with β-PPA in early AMD patients. Secondary outcomes included the association of RPD and preexisting diagnosis of glaucoma, cup-to-disc ratio (CDR), subfoveal choroidal thickness (SFCT), and IOP. Methods: This prospective cross-sectional study examined 78 age- and sex-matched early AMD patients: 43 RPD patients (63 eyes) and 35 non-RPD patients (64 eyes)...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28490860/choroidal-structure-determined-by-binarizing-optical-coherence-tomography-images-in-eyes-with-reticular-pseudodrusen
#15
Naonori Masuda, Masashi Kojima, Mariko Yamashita, Tomo Nishi, Nahoko Ogata
PURPOSE: To compare the choroidal structure beneath the macular area in eyes with reticular pseudodrusen (RPD) and age-matched controls. METHODS: This study was performed at Nara Medical University Hospital, Japan. Twenty eyes of 14 patients (82.3±4.2 years, mean ± standard deviation) with RPD and 35 eyes of 20 age-matched controls (81.5±6.0 years) were studied. The choroidal structure was determined by binarizing the images obtained by enhanced depth imaging optical coherence tomography in all patients and controls...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28453367/retinal-pigment-epithelium-photoreceptor-layer-alterations-in-a-patient-with-sturge-weber-syndrome-with-diffuse-choroidal-hemangioma
#16
Solmaz Abdolrahimzadeh, Francesco Parisi, Flavio Mantelli, Andrea Perdicchi, Gianluca Scuderi
PURPOSE: To describe an 8-year-old girl with diagnosis of Sturge-Weber syndrome (SWS) presenting with glaucoma, abnormal iris vessels, diffuse choroidal hemangioma, and small white dot-shaped "microdrusen-like" alterations of the retina in the right eye. PATIENT AND METHODS: Complete ophthalmological examination was performed with slit-lamp anterior segment assessment and fundus ophthalmoscopy. Near infrared reflectance (NIR) and enhanced depth imaging (EDI) spectral domain optical coherence tomography (SD-OCT) were carried out...
April 28, 2017: Ophthalmic Genetics
https://www.readbyqxmd.com/read/28388704/quantitative-analysis-of-the-ellipsoid-zone-intensity-in-phenotypic-variations-of-intermediate-age-related-macular-degeneration
#17
Thomas J Gin, Zhichao Wu, Sky K H Chew, Robyn H Guymer, Chi D Luu
Purpose: Reduction of the ellipsoid zone (EZ) intensity has been reported in eyes with age-related macular degeneration (AMD). This study determined whether overall EZ intensity, in retinal locations undisturbed by pathologic features, is associated with the presence of clinical features, which are known important phenotypic risk factors for disease progression, large drusen, reticular pseudodrusen (RPD), and pigmentary abnormalities. Methods: A horizontal B-scan through the foveola on spectral-domain optical coherence tomography (SD-OCT) was performed in both eyes of 75 participants with bilateral intermediate AMD and 10 age-similar control participants...
April 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28282065/fundus-autofluorescence-imaging-systematic-review-of-test-accuracy-for-the-diagnosis-and-monitoring-of-retinal-conditions
#18
REVIEW
G K Frampton, N Kalita, L Payne, J L Colquitt, E Loveman, S M Downes, A J Lotery
We conducted a systematic review of the accuracy of fundus autofluorescence (FAF) imaging for diagnosing and monitoring retinal conditions. Searches in November 2014 identified English language references. Sources included MEDLINE, EMBASE, the Cochrane Library, Web of Science, and MEDION databases; reference lists of retrieved studies; and internet pages of relevant organisations, meetings, and trial registries. For inclusion, studies had to report FAF imaging accuracy quantitatively. Studies were critically appraised using QUADAS risk of bias criteria...
July 2017: Eye
https://www.readbyqxmd.com/read/28270492/retinal-pigment-epithelial-features-indicative-of-neovascular-progression-in-age-related-macular-degeneration
#19
Philipp K Roberts, Bernhard Baumann, Ferdinand G Schlanitz, Stefan Sacu, Matthias Bolz, Michael Pircher, Michael Hagmann, Christoph K Hitzenberger, Ursula Schmidt-Erfurth
BACKGROUND/AIMS: To identify characteristic retinal pigment epithelium (RPE) changes in fellow eyes of patients with neovascular age-related macular degeneration (nAMD) using polarisation-sensitive optical coherence tomography (PS-OCT). METHODS: Thirty-one fellow eyes of 31 patients with unilateral nAMD were evaluated in this cohort study of a prospective interventional trial. PS-OCT as well as conventional imaging including spectral-domain (SD)-OCT and fluorescein angiography (FA) were performed using a standardised protocol...
October 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28265823/changes-in-reticular-pseudodrusen-area-in-eyes-that-progressed-from-early-to-late-age-related-macular-degeneration
#20
Patrick A Kaszubski, Tal Ben Ami, Céline Saade, Camellia Nabati, Vivek Kumar, Ana Rita Santos, Rufino Silva, Maria Luz Cachulo, José G Cunha-Vaz, R Theodore Smith
OBJECTIVE: This retrospective cohort study utilized 3 imaging modalities to analyze quantitatively reticular pseudodrusen (RPD) area changes in eyes that progressed from early to late age-related macular degeneration (AMD). METHODS: Subjects with AMD, unilateral choroidal neovascularization (CNV), and early AMD with RPD in the fellow eye (the study eye) were included. The study eyes underwent indocyanine green angiography (ICGA), near-infrared reflectance (NIR-R), and short-wavelength autofluorescence (AF) imaging of the macula at baseline and at follow-up...
March 7, 2017: International Ophthalmology
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