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https://www.readbyqxmd.com/read/28935491/measurement-of-uterine-natural-killer-unk-cell-percentage-in-the-peri-implantation-endometrium-from-fertile-women-and-women-with-recurrent-reproductive-failure-establishment-of-a-reference-range
#1
Xiaoyan Chen, Najat Mariee, Lingming Jiang, Yingyu Liu, Chi Chiu Wang, Tin Chiu Li, Susan Laird
BACKGROUND: Uterine natural killer (uNK) cells are the major leucocytes present in the peri-implantation endometrium. Previous studies have found controversial differences in uNK cell percentage in women suffering from recurrent reproductive failure, compared with fertile controls. OBJECTIVE: To compare the uNK cell percentage in women with recurrent reproductive failure and fertile controls. STUDY DESIGN: It was a retrospective study carried out in university hospitals...
September 18, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28928434/the-effect-of-frozen-thawed-embryo-transfer-performed-concurrently-with-hysteroscopy-on-the-reproductive-outcomes-during-assisted-reproductive-treatments
#2
Xiuxian Zhu, Hongjuan Ye, Yonglun Fu
The uterine environment is vital to the successful conception; recently, hysteroscopy was used to remove uterine anomalies in patients undergoing assisted reproductive treatments in combination with a "freeze-all" strategy. However, the rapid recurrence of uterine anomalies impose a negative impact on pregnancy. A possible way to avoid this issue is to implement frozen-thawed embryo transfer (FET) as soon as possible. Thus, we sought to investigate the impact of performing FET concurrently with hysteroscopy in the same mense on the pregnancy outcome...
September 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28924537/inherited-thrombophilias-could-influence-the-reproductive-outcome-in-women-with-systemic-lupus-erythematosus
#3
R Robeva, D Tanev, S Andonova, M Nikolova, A Tomova, Ph Kumanov, A Savov, R Rashkov, Zl Kolarov
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease associated with different reproductive complications in the affected women. Inherited thrombophilias are genetic factors increasing the risk for thromboembolism and recurrent pregnancy loss, but their influence on other reproductive disturbances in SLE patients has not been completely clarified. Two hundred and twenty-three Caucasian women (112 with SLE and 111 controls) were included in the study. Complete reproductive history of all SLE patients was carefully obtained...
June 30, 2017: Balkan Journal of Medical Genetics: BJMG
https://www.readbyqxmd.com/read/28923404/hla-g-coding-region-polymorphism-is-skewed-in-autistic-spectrum-disorders
#4
Franca R Guerini, Elisabetta Bolognesi, Matteo Chiappedi, Enrico Ripamonti, Alessandro Ghezzo, Michela Zanette, Stefano Sotgiu, Maria Martina Mensi, Alessandra Carta, Maria Paola Canevini, Milena Zanzottera, Cristina Agliardi, Andrea S Costa, Umberto Balottin, Mario Clerici
Different isoforms of HLA-G protein are endowed with a differential ability to induce allogenic tolerance during pregnancy. As prenatal immune activation is suggested to play a role in the onset of autistic spectrum disorders (ASD), we evaluated HLA G*01:01-*01:06 allelic polymorphism in a cohort of Italian children affected by ASD (N=111) their mothers (N=81), and their healthy siblings (N=39). DNA sequencing analysis of HLA-G exon 2, 3 and 4 was used to obtain HLA-G allelic frequencies; alleles distribution was compared with that of two control groups of Caucasoid couples of multiparous women and their partners from Brazil and Denmark...
September 18, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28900713/complement-activation-a-threat-to-pregnancy
#5
REVIEW
Guillermina Girardi
Pregnancy poses a challenge for the immune systems of placental mammals. As fetal tissues are semi-allogeneic and alloantibodies that commonly develop in the mother, the fetus and the placenta might be subject to complement-mediated immune attack with the potential risk of adverse pregnancy outcomes. Here, I describe how the use of animal models was pivotal in demonstrating that complement inhibition at the fetomaternal interface is essential for a successful pregnancy. Studies in animals also helped the identification of uncontrolled complement activation as a crucial effector in the pathogenesis of recurrent miscarriages, intrauterine growth restriction, preeclampsia, and preterm birth...
September 12, 2017: Seminars in Immunopathology
https://www.readbyqxmd.com/read/28867860/ayurvedic-management-of-recurrent-abortions-due-to-uterine-fibroid
#6
Shailendra Dadarao Katakdound
Uterine fibroids are present in 30-70% of women of reproductive age. Uterine fibroids distort the uterine cavity. Therefore there is consensus of a negative impact on both the clinical pregnancy and delivery rates.[2] In addition, studies have also reported an increased risk of spontaneous miscarriage with submucosal fibroids. In biomedicine, myomectomy is considered the treatment of choice and Assisted Reproductive Technology is advised to overcome infertility. In Hārita Saṃhitā treatment is given for recurrent abortion (Garbhasrāvī)...
January 2017: Ancient Science of Life
https://www.readbyqxmd.com/read/28865602/placental-apoptosis-in-recurrent-miscarriage
#7
Tarek A Atia
Apoptosis is an interactive and dynamic biological process involved in all phases of embryogenesis. We aimed to study the effect of placental apoptosis on recurrent miscarriage (RM). Placental tissue samples were collected from 40 women with RM (study group) and 30 women with sporadic spontaneous abortion (control group). Samples were prepared and stained immunohistochemically with markers for both the apoptotic protein (p53) and anti-apoptotic Bcl-2 antibodies. Our results showed that expression of the apoptotic (p53) protein was significantly increased in the placental tissues of the RM group (p = 0...
September 2017: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/28863939/semen-quality-and-pregnancy-loss-in-a-contemporary-cohort-of-couples-recruited-before-conception-data-from-the-longitudinal-investigation-of-fertility-and-the-environment-life-study
#8
Michael L Eisenberg, Katherine J Sapra, Sung Duk Kim, Zhen Chen, Germaine M Buck Louis
OBJECTIVE: To study the relationship between semen quality and pregnancy loss in a cohort of couples attempting to conceive. DESIGN: Observational prospective cohort. SETTING: Not applicable. PATIENT(S): Three hundred and forty-four couples with a singleton pregnancy observed daily through 7 postconception weeks of gestation. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Association between semen quality and pregnancy loss...
August 29, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28854581/unexplained-recurrent-miscarriages-are-associated-with-an-aberrant-sperm-protamine-mrna-content
#9
Nina Rogenhofer, Johannes Ott, Adrian Pilatz, Julia Wolf, Christian J Thaler, Lisa Windischbauer, Undraga Schagdarsurengin, Klaus Steger, Viktoria von Schönfeldt
STUDY QUESTION: Are unexplained recurrent miscarriages associated with abnormal protamine-1 and protamine-2 mRNA levels in spermatozoa? SUMMARY ANSWER: Both protamine-1 and protamine-2 mRNA levels as well as the protamine-1 to protamine-2 mRNA ratio in spermatozoa from men whose female partners experienced two or more consecutive miscarriages were significantly different compared to those from both healthy control men and subfertile couples undergoing IVF/ICSI. WHAT IS KNOWN ALREADY: Aberrant sperm protamine ratios are known to be associated with male-factor infertility...
August 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28836548/epidemiological-survey-and-risk-factor-analysis-of-recurrent-spontaneous-miscarriages-in-infertile-women-at-large-infertility-centers
#10
Hai-Yan Wang, Jie Qiao, Xiao-Xi Sun, Shu-Yu Wang, Xiao-Yan Liang, Yun Sun, Feng-Hua Liu
BACKGROUND: A higher frequency of spontaneous miscarriage has been observed in infertile couples, and there is a higher prevalence of infertility among patients with a history of recurrent spontaneous miscarriages (RSMs; ≥2 miscarriages). This study aimed to determine the proportion of infertile patients with RSM and examine risk factors associated in patients with RSM being treated with assisted reproductive technologies. METHODS: This cross-sectional observational study was conducted at six reproductive medicine centers in three cities of China...
September 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28832895/is-the-incidence-of-recurrent-pregnancy-loss-increasing-a-retrospective-register-based-study-in-sweden
#11
Emma Rasmark Roepke, Leif Matthiesen, Rebecca Rylance, Ole Bjarne Christiansen
INTRODUCTION: The aim of this study was to estimate the incidence of recurrent pregnancy loss (RPL). The prevalence of RPL defined as ≥3 consecutive miscarriages before gestation week 22, is often stated to be 1%. To our knowledge no study has estimated the incidence of RPL, which might be more informative and clinically relevant than the prevalence. MATERIAL AND METHODS: This retrospective register-based study was conducted from 2003 until 2012 in Sweden with data provided by the Swedish National Board of Health and Welfare...
August 18, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28826362/mir-3074-5p-promotes-the-apoptosis-but-inhibits-the-invasiveness-of-human-extravillous-trophoblast-derived-htr8-svneo-cells-in-vitro
#12
Yan Gu, Yan Shi, Qian Yang, Wen-Wen Gu, Ya-Ping He, Hua-Jun Zheng, Xuan Zhang, Jian-Mei Wang, Jian Wang
OBJECTIVE: The objective of this study was to observe the effects of the overexpression of miR-3074-5p in human trophoblast cells in vitro. DESIGN: Experimental in vitro study in HTR8/SVneo cells. METHODS: HTR8/SVneo cells were transfected with miR-3074-5p mimic. The cell apoptosis and invasion were measured via flow cytometry and transwell assay, respectively. The expression levels of P53, Cyclin Dependent Kinase Inhibitor 1B (P27), BCL-2, BCL2 associated X (BAX), and BCL2 like 14 (BCL-G) in HTR8/SVneo cells were determined by Western blot...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28825972/angiogenesis-and-oxidative-stress-related-gene-variants-in-recurrent-pregnancy-loss
#13
Marcela Felix Fortis, Lucas Rosa Fraga, Juliano André Boquett, Thayne Woycinck Kowalski, Caroline Gross Dutra, Rozana Oliveira Gonçalves, Fernanda Sales Luiz Vianna, Lavinia Schüler-Faccini, Maria Teresa Vieira Sanseverino
Recurrent pregnancy loss (RPL) affects ~3-5% of couples attempting to conceive and in around 50% of cases the aetiology remains unknown. Adequate vascularisation and placental circulation are indispensable for the development of a normal pregnancy. Prostaglandin-endoperoxide synthase 2 (PTGS2), vascular endothelial growth factor (VEGF) and the nitric oxide (NO) systems play important roles in reproductive physiology, participating in several steps including implantation and apoptosis of trophoblast cells. In this study we evaluated genetic polymorphisms in the inducible nitric oxide synthase (NOS2), PTGS2 and VEGFA genes as susceptibility factors for RPL...
August 22, 2017: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/28820405/antiphospholipid-syndrome-and-monocytes-new-aspects
#14
A Blbulyan, A Martirosyan, M Petrek, Z Navratilova, G Manukyan
After discovery of antiphospholipid syndrome (APS) our understanding of molecular mechanisms of living matter has become more sophisticated and on this way monocytes has become crucial player, particularly in pathogenesis of APS. Thrombotic and non-thrombotic complications of APS could be explained by monocytes' activation too. But mechanisms underlying their activation are poorly investigated. So we aimed to determine transcriptional activity of monocytes after exposing them to low concentrations of lipopolysaccharide (LPS) and LPS+ATP using comparative of RT-PCR...
July 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28819944/contribution-of-inherited-thrombophilia-to-recurrent-miscarriage-in-the-polish-population
#15
Hubert Wolski, Magdalena Barlik, Krzysztof Drews, Andrzej Klejewski, Grażyna Kurzawińska, Marcin Ożarowski, Zdzisław Łowicki, Agnieszka Seremak-Mrozikiewicz
INTRODUCTION: The aim of the study was to evaluate the contribution of genetic variants determining inherited thrombophilia to recurrent miscarriage (RM) in the Polish population. The following polymorphisms were analyzed: 1691G>A, 1328T>C of coagulation factor V, 20210G>A of coagulation factor II, R353Q (11496G>A) of coagulation factor VII, 667C>T, 1298A>C, 1793G>A of MTHFR. MATERIAL AND METHODS: A total of 359 women with ≥ 2 subsequent recurrent miscarriages (303 < 13 weeks of gestation (w...
2017: Ginekologia Polska
https://www.readbyqxmd.com/read/28810880/nlrp7-contributes-to-in-vitro-decidualization-of-endometrial-stromal-cells
#16
Jyun-Yuan Huang, Pei-Hsiu Yu, Yueh-Chun Li, Pao-Lin Kuo
BACKGROUND: Nucleotide-binding oligomerization domain (NACHT), leucine rich repeat (LRR) and pyrin domain (PYD) 7 containing protein, NLRP7, is a member of the NLR family which serves as innate immune sensors. Mutations and genetic variants of NLRP7 have been found in women with infertility associated conditions, such as recurrent hydatidiform mole, recurrent miscarriage, and preeclampsia. Decidualization of endometrial stromal cells is a hallmark of tissue remodeling to support embryo implantation and proper placental development...
August 15, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28807722/coronary-microvascular-dysfunction-is-not-associated-with-a-history-of-reproductive-risk-factors-in-women-with-angina-pectoris-an-ipower-substudy
#17
Hannah Elena Suhrs, Anna Meta Kristensen, Anna Bay Rask, Marie Mide Michelsen, Daria Frestad, Naja Dam Mygind, Kira Bové, Eva Prescott
BACKGROUND: Reproductive risk factors such as preeclampsia and recurrent miscarriages have been associated with adverse cardiovascular (CV) events. Underlying coronary microvascular dysfunction (CMD) may be a common denominator. PURPOSE: We investigated whether a history of reproductive risk factors was associated with CMD in women with angina pectoris and no obstructive coronary artery disease (CAD). METHODS: Participants from the iPOWER study, including women with angina pectoris and no obstructive CAD (<50% stenosis), were invited to complete an electronic survey regarding reproductive risk factors: recurrent miscarriages, gestational diabetes, preeclampsia, rhesus immunity, polycystic ovary syndrome and menopausal status as well as migraine and Raynaud phenomenon...
August 11, 2017: Maturitas
https://www.readbyqxmd.com/read/28805116/bisphenol-a-and-adverse-pregnancy-outcomes-a-systematic-review-of-the-literature
#18
Vasilios Pergialiotis, Paraskevi Kotrogianni, Evangelos Christopoulos-Timogiannakis, Diamanto Koutaki, Georgios Daskalakis, Nikolaos Papantoniou
PURPOSE: Bisphenol A is a chemical compound related to adverse maternal and neonatal outcomes. The purpose of the present systematic review is to summarize the current knowledge in the field. MATERIALS AND METHODS: We systematically searched the Medline (1966-2017), Scopus (2004-2017), Clinicaltrials.gov (2008-2017), Cochrane Central Register of Controlled Trials CENTRAL (1999-2017) databases. RESULTS: Thirty-five studies were included in the present systematic review...
August 24, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28801981/pregnancy-outcomes-in-mothers-of-offspring-with-inherited-bone-marrow-failure-syndromes
#19
Neelam Giri, Helen D Reed, Pamela Stratton, Sharon A Savage, Blanche P Alter
BACKGROUND: Children with inherited bone marrow failure syndromes (IBMFSs) may be symptomatic in utero, resulting in maternal and fetal problems during the pregnancy. Subsequent pregnancies by their mothers should be considered "high risk". METHODS: We retrospectively analyzed outcomes of 575 pregnancies in 165 unaffected mothers of offspring with Fanconi anemia (FA), dyskeratosis congenita (DC), Diamond-Blackfan anemia (DBA), and Shwachman-Diamond syndrome (SDS) for events noted during pregnancy, labor, and delivery...
August 12, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28797766/pregnancy-outcomes-after-a-breast-cancer-diagnosis-a-systematic-review-and-meta-analysis
#20
REVIEW
Brigitte Gerstl, Elizabeth Sullivan, Angela Ives, Christobel Saunders, Handan Wand, Antoinette Anazodo
Improvements in local and systemic treatment, along with earlier diagnoses through breast awareness and screening, have led to increases in survival and a decline in breast cancer (BC) recurrence. To the best of our knowledge, no meta-analysis has yet focused on pregnancy outcomes after BC treatment. Hence, our research group explored the reproductive outcomes (pregnancy, miscarriage, termination of pregnancy, live births) after BC treatment. The Embase, MEDLINE, PubMed, and Scopus databases were searched. Studies were included that reported on pregnancy and reproductive outcomes after treatment of BC...
July 10, 2017: Clinical Breast Cancer
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