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https://www.readbyqxmd.com/read/29349485/undiagnosed-primary-hyperparathyroidism-and-recurrent-miscarriage-the-first-prospective-pilot-study
#1
Aimee DiMarco, Ioannis Christakis, Vasilis Constantinides, Lesley Regan, F Fausto Palazzo
BACKGROUND: Primary hyperparathyroidism (pHPT) in pregnancy is reported to be associated with significant maternal and foetal complications and an up to threefold increase in the risk of miscarriage. However, the true incidence of pHPT in pregnancy, complete and miscarried, is unknown and there are no data on the prevalence of undiagnosed pHPT in recurrent miscarriage (RM) (≥3 consecutive miscarriages under 24-week gestation). This is the first prospective study aiming to establish the prevalence of undiagnosed pHPT in RM...
January 18, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29336298/-diagnosis-of-vaginal-discharge
#2
Sidsel Böcher, Rikke Bek Helmig, Magnus Arpi, Lars Bjerrum
Changes in vaginal discharge are often caused by imbalance in the vaginal microflora, and laboratory testing is usually of little use, as most microbes detected are commensals. In-office diagnosis in general practice using wet mount microscopy and Amsel criteria is helpful and often sufficient to ensure correct diagnosis and treatment. Laboratory testing of vaginal discharge should only be performed, if sexually transmitted disease is suspected, if there is treatment failure or inconclusive wet mount prior to gynaecological surgery, and in pregnant women with recurrent miscarriage or preterm birth...
January 15, 2018: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/29329377/endometrial-stem-cell-derived-g-csf-attenuates-endometrial-fibrosis-via-sonic-hedgehog-transcriptional-activator-gli2
#3
Xiaona Lin, Yanling Zhang, Yibin Pan, Shilin He, Yongdong Dai, Bingqing Zhu, Cheng Wei, Liaobing Xin, Wenzhi Xu, Chunsheng Xiang, Songying Zhang
Intrauterine adhesion (IUA) is characterized by endometrial fibrosis, which ultimately leads to menstrual abnormalities, infertility and recurrent miscarriages. The Shh/Gli2 pathway plays a critical role in tissue fibrogenesis and regeneration; Gli2 activation induces profibrogenic effects in various tissues, such as the liver and kidney. However, the role of Gli2 in endometrial fibrosis remains unknown. The purpose of this study was to test the hypothesis that activated Gli2 promotes endometrial fibrosis. Endometrial samples from moderate and severe IUA patients exhibited significantly enhanced expression of Gli2 compared with normal endometrial samples and mild IUA samples...
January 10, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29328024/endometrial-polyps-in-women-of-reproductive-age-clinical-and-pathogene-tic-variations
#4
N Kosei, N Zakharenko, D Herman
The aim of the study was to study the relationship between the morphofunctional characteristics of the endometrium, hormonal homeostasis and microbiocenosis of the reproductive system in patients with endometrial polyps. The study involved 130 patients aged 18-35 years: 34 patients with endometrial polyps, 30 patients with micropolyps, 36 patients with endometrial polyps and micropolyps, 30 healthy women of the control group. Hysteroscopy was performed for women who had been suspected for endometrial polyps and who had infertility or repeated recurrent miscarriages...
December 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29321641/antiphospholipid-syndrome
#5
REVIEW
Karen Schreiber, Savino Sciascia, Philip G de Groot, Katrien Devreese, Soren Jacobsen, Guillermo Ruiz-Irastroza, Jane E Salmon, Yehuda Shoenfeld, Ora Shovman, Beverley J Hunt
Antiphospholipid syndrome (APS) is an autoimmune disease characterized by the presence of antiphospholipid antibodies, such as lupus anticoagulant, anticardiolipin antibodies and anti-β2-glycoprotein 1 antibodies. APS can present with a variety of clinical phenotypes, including thrombosis in the veins, arteries and microvasculature as well as obstetrical complications. The pathophysiological hallmark is thrombosis, but other factors such as complement activation might be important. Prevention of thrombotic manifestations associated with APS includes lifestyle changes and, in individuals at high risk, low-dose aspirin...
January 11, 2018: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/29305234/reproductive-outcomes-after-fertility-sparing-surgery-for-focal-and-diffuse-adenomyosis-a-systematic-review
#6
REVIEW
Justin Tan, Sophie Moriarty, Omur Taskin, Catherine Allaire, Christina Williams, Paul Yong, Mohamed A Bedaiwy
Among the variety of treatment options to improve reproductive outcomes for infertile women with adenomyosis (AD), uterine conserving surgery has demonstrated varying success. Hence, we conducted a systematic review around the topic of fertility-sparing surgery across 18 studies and 1396 infertile women with focal and diffuse AD. Patients with focal AD demonstrated mean pregnancy and miscarriage rates of 52.7% (range:14.3-77.5%) and 21.1% (range:0-44.4%), respectively, while patients with diffuse AD had a mean pregnancy and miscarriage rate of 34...
January 2, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29301604/bilateral-choroidal-occlusion-in-antiphospholipid-syndrome-associated-with-systemic-lupus-erythematosus
#7
Yang Zhang, Shun-Hua Zhang, Ai-Ling Bian, You-Xin Chen
This article reports a rare case of bilateral choroidal occlusion that occurred in a 24-year-old woman with antiphospholipid syndrome (APS) associated with systemic lupus erythematosus (SLE). This young lady concurred with aorta ventralis thrombosis and bilateral iliac artery occlusion when presented, and experienced a rapid deterioration of vision. She also has a history of recurrent miscarriage. Corticosteroid, immunosuppression and anticoagulation therapy were administered. Patients with APS associated with SLE are at risk for thrombotic phenomena, which may affect the ocular vessels of all sizes, including choroidal vessel...
December 30, 2017: Chinese Medical Sciences Journal, Chung-kuo i Hsüeh K'o Hsüeh Tsa Chih
https://www.readbyqxmd.com/read/29280596/the-hla-g-14bp-insertion-deletion-polymorphism-and-its-association-with-soluble-hla-g-levels-in-women-with-recurrent-miscarriages
#8
V Kalotra, M Lall, I C Verma, A Kaur, A Kaur
Human leucocyte antigen-G (HLA-G), a non classical class Ib gene is mainly expressed on extravillous trophoblasts at the fetal-maternal interface. HLA-G molecule is considered to play an important role in maternal immune suppression during pregnancy. 14bp insertion/deletion polymorphism (rs66554220) in exon 8 of the HLA-G gene influences HLA-G mRNA stability and isoform splicing patterns. In the present study, 202 RM women with two or more than two consecutive miscarriages, their 202 partners and 204 fertile control women with at least one live birth and no miscarriages were analyzed for 14bp insertion/deletion polymorphism...
December 27, 2017: HLA
https://www.readbyqxmd.com/read/29277275/towards-standardized-criteria-for-diagnosing-chronic-intervillositis-of-unknown-etiology-a-systematic-review
#9
REVIEW
M Bos, P G J Nikkels, D Cohen, J W Schoones, K W M Bloemenkamp, J A Bruijn, H J Baelde, M L P van der Hoorn, R J Turner
Chronic intervillositis of unknown etiology (CIUE) is a poorly understood, relatively rare condition characterized histologically by the intervillous infiltration of mononuclear cells in the placenta. Clinically, CIUE is associated with poor pregnancy outcome (e.g., impaired fetal growth, preterm birth, fetal death) and high risk of recurrence in subsequent pregnancies. Because CIUE is not defined consistently, it is essential to clearly define this condition. We therefore review the published definitions of CIUE...
January 2018: Placenta
https://www.readbyqxmd.com/read/29277264/proteomics-and-bioinformatics-analysis-of-altered-protein-expression-in-the-placental-villous-tissue-from-early-recurrent-miscarriage-patients
#10
Hai-Tao Pan, Hai-Gang Ding, Min Fang, Bin Yu, Yi Cheng, Ya-Jing Tan, Qi-Qin Fu, Bo Lu, Hong-Guang Cai, Xin Jin, Xian-Qing Xia, Tao Zhang
INTRODUCTION: Recurrent miscarriage (RM) affects 5% of women, it has an adverse emotional impact on women. Because of the complexities of early development, the mechanism of recurrent miscarriage is still unclear. We hypothesized that abnormal placenta leads to early recurrent miscarriage (ERM). The aim of this study was to identify ERM associated factors in human placenta villous tissue using proteomics. Investigation of these differences in protein expression in parallel profiling is essential to understand the comprehensive pathophysiological mechanism underlying recurrent miscarriage (RM)...
January 2018: Placenta
https://www.readbyqxmd.com/read/29276169/prevalence-and-treatment-choices-for-couples-with-recurrent-pregnancy-loss-due-to-structural-chromosomal-anomalies
#11
Savanie Maithripala, Ursula Durland, Jon Havelock, Sonya Kashyap, Jason Hitkari, Justin Tan, Mahmoud Iews, Sarka Lisonkova, Mohamed A Bedaiwy
OBJECTIVE: Parental carriers of balanced structural chromosomal rearrangements such as reciprocal or Robertsonian translocations are at increased risk of recurrent pregnancy loss (RPL) due to the production of gametes with unbalanced non-viable chromosome variants. As a purported means of improving reproductive outcomes in this population, IVF and preimplantation genetic diagnosis (PGD) have been introduced as an alternative to natural conception and prenatal diagnosis. In this study, we evaluate the prevalence and treatment choices of couples with structural chromosomal rearrangement referred to a tertiary care RPL clinic...
December 21, 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/29275238/simultaneous-pregnancy-in-each-uterine-cavity-of-a-double-uterus-in-a-young-nigerian-multipara-who-presented-with-a-retained-second-twin-following-an-unsupervised-preterm-labor-at-home-case-report
#12
Emmanuel Oluchikwu Ani, Emmanuel Ajuluchukwu Ugwa, Aminu Bashir Taiye, Iwasam Elemi Agbor, Ibrahim Shaaibu Suleiman
INTRODUCTION: Simultaneous pregnancy in each uterine cavity of a double uterus is unusual but is a recognized risk factor for preterm labour and other poor obstetrics outcomes. The work has been reported in line with the SCARE criteria. PRESENTATION OF CASE: We report an unusual case of simultaneous pregnancy in each uterine cavity of a double uterus in a young African grand multipara who presented with a retained second twin following a preterm labour at home. DISCUSSION: A double or didelphys uterus as reported in the literatures is still uncommon even in Africa...
December 13, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29272996/spontaneous-first-trimester-miscarriage-rates-per-woman-among-parous-women-with-1-or-more-pregnancies-of-24-weeks-or-more
#13
Judy Slome Cohain, Rina E Buxbaum, David Mankuta
BACKGROUND: The purpose of this study was to quantify spontaneous first trimester miscarriage rates per woman among parous women. A vast amount of data has accumulated regarding miscarriage rates per recognized pregnancy as well as about recurrent miscarriage. This is the second study of miscarriage rates per woman in a parous population and the first study of recurrent and non-recurrent, spontaneous first trimester miscarriage rates per woman in a large parous population. METHODS: Extraction of the following variables from all delivery room admissions from both Hadassah Medical Centers in Jerusalem Israel, 2004-2014: # of first trimester spontaneous miscarriages, # live births; # living children; age on admission, pre-pregnancy height and weight, any smoking this pregnancy, any alcohol or drug abuse this pregnancy, blood type, history of ectopic pregnancy, history of cesarean surgery (CS) and use of any fertility treatment(s)...
December 22, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29259481/after-12-consecutive-miscarriages-a-patient-received-immunosuppressive-treatment-and-delivered-an-intact-baby
#14
Koji Nakagawa, Keiji Kuroda, Rikikazu Sugiyama, Koushi Yamaguchi
Aim: An immune etiology for idiopathic recurrent miscarriage is an important issue because a fetus is allogenetically different from the mother. Type 1 T helper (Th1) and Type 2 (Th2) cells have important functions in immune responses and there is a general agreement that pregnancy is associated with Th2 cell dominance. The purpose of this case report is to establish the effectiveness of an immunosuppressive treatment for a patient who had 11 consecutive miscarriages despite several treatments, such as anticoagulation, that showed elevated Th1/Th2 cell ratios...
July 2017: Reproductive Medicine and Biology
https://www.readbyqxmd.com/read/29248666/hydrosalpinx-sclerotherapy-before-in-vitro-fertilization-systematic-review-and-meta-analysis
#15
REVIEW
Aviad Cohen, Benny Almog, Togas Tulandi
The presence of hydrosalpinx has been shown to impair the outcome of in-vitro fertilization (IVF) treatment. This outcome can be improved by removal of the hydrosalpinx; however, there are some concerns regarding its feasibility and safety especially in women with previous surgeries and dense adhesions. The purpose of our meta-analysis was to evaluate the efficacy of hydrosalpinx aspiration with or without sclerotherapy on the risk of recurrence and on the IVF outcome as compared to salpingectomy or no-intervention...
December 14, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29246150/low-dose-lymphocyte-immunotherapy-rebalances-the-peripheral-blood-th1-th2-treg-paradigm-in-patients-with-unexplained-recurrent-miscarriage
#16
Mengyuan Liu, Xin Zhen, Hongyan Song, Junhao Chen, Xiaoling Sun, Xiaoqin Li, Jianjun Zhou, Guijun Yan, Lijun Ding, Haixiang Sun
BACKGROUND: The published results regarding lymphocytes immunotherapy for unexplained recurrent miscarriage (uRM) patients are conflicting due to different screening criteria and therapeutic protocols. The objective of the present study is to evaluate the effectiveness of immunotherapy using low-dose lymphocytes in patients with uRM and Th1/Th2/Treg paradigm disorders. METHODS: Sixty-four uRM patients who received low-dose lymphocytes immunotherapy served as the immunotherapy group, while the other 35 women who did not receive the treatment served as the control group...
December 16, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/29234375/kidney-replenishing-herb-induces-socs-3-expression-via-erk-mapk-pathway-and-improves-growth-of-the-first-trimester-human-trophoblast-cells
#17
Chang-Ying Xing, De-Xiang Zhang, Sui-Qi Gui, Min-Fang Tao
Kidney-replenishing herb is a traditional medicine formula in China which has been widely used for clinical treatment of recurrent miscarriage. Our previous study showed that Kidney-replenishing herb could promote proliferation and inhibit apoptosis of the human first-trimester trophoblasts. In the present study, we further explored the potential mechanism and signal pathway of Kidney-replenishing herb on human trophoblast cells. Our research showed that Kidney-replenishing herb stimulated proliferation and reduced apoptosis of human trophoblast cells in vitro, and this appeared to be positive correlation with SOCS-3 transcription, suggesting that Kidney-replenishing herb regulated biological functions of human trophoblast cells by inducing SCOS-3 expression...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29225675/pregnancy-and-myeloproliferative-neoplasms-a-retrospective-monocentric-cohort
#18
Mathieu Puyade, Emilie Cayssials, Fabrice Pierre, Olivier Pourrat
Background: The most frequent myeloproliferative neoplasms are essential thrombocythemia and chronic myelogenous leukemia, which usually manifests with thrombocytosis. Only essential thrombocythemia is associated with morbidity during pregnancy (recurrent miscarriages, intrauterine fetal death, small for gestational age and preeclampsia). The aim of this paper is to describe outcomes of pregnancy in women with myeloproliferative neoplasms seen at a single academic institution. Methods: Data were collected retrospectively from 2002 to 2015...
December 2017: Obstetric Medicine
https://www.readbyqxmd.com/read/29221937/recurrent-miscarriage-is-associated-with-increased-ghrelin-mrna-expression-in-the-endometrium-a-case-control-study
#19
Aneta Zwierzchowska, Anna Iwan, Anna Hyc, Barbara Suchońska, Jacek Malejczyk, Ewa Barcz
Ghrelin has been found to be expressed in the human endometrium. Emerging evidence links ghrelin and its receptor with the reproductive system. Certain associations between ghrelin and angiogenesis have also been established. The aim of this small case-control study was to quantify and compare the expression of mRNA encoding ghrelin, ghrelin receptor (GHS-R), vascular endothelial growth factor A (VEGF A) and its receptors (VEGFR1-3) in the endometrium of women with recurrent miscarriage compared to parous controls...
December 5, 2017: Reproductive Biology
https://www.readbyqxmd.com/read/29220118/traditional-and-molecular-chromosomal-abnormality-analysis-of-products-of-conception-in-spontaneous-and-recurrent-miscarriage
#20
REVIEW
Ting Zhang, Yun Sun, Zi-Jiang Chen, T C Li
Chromosome abnormalities account for half of miscarriages. Data from cytogenetic analysis of the products of conception (POC) in miscarriages are reviewed in the paper. Genetic analysis of POC allows patients to be given prognostic information. Molecular genetic techniques can overcome the pitfalls of conventional karyotyping such as culture failure and trace submicroscopic abnormalities. We compare the pros and cons when these technologies are applied to the analysis of POC of miscarriage. Guidance is also provided for future clinical applications...
December 8, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
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