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Journal of Biochemistry

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https://www.readbyqxmd.com/read/27885153/karl-otto-landsteiner-1868-1943-physician-biochemist-immunologist
#1
Armond S Goldman, Frank C Schmalsteig
Karl Landsteiner applied the sciences of biochemistry, pathology, microbiology, and immunology in medical research to great success during the first half of the 20th century. Although he is principally known for elucidating the major blood group antigens A and B and their isoantibodies for which he was awarded the Nobel Prize in Physiology or Medicine, Landsteiner made many other important medical discoveries. In that respect, he ascertained that paralytic poliomyelitis was due to a virus, the pancreas was damaged in cystic fibrosis, simple chemicals called haptens were able to combine with antibodies, and the Rh antigen that was later found to be the principal cause of hemolytic anemia of the newborn was found in most humans...
November 24, 2016: Journal of Medical Biography
https://www.readbyqxmd.com/read/27872676/progressive-and-self-limiting-neurodegenerative-disorders-in-africa-a-new-prominent-field-of-research-led-by-south-africa-but-without-strong-health-policy
#2
Brice Poreau
INTRODUCTION: Neurodegenerative disorders are involved in mortality and morbidity of every country. A high prevalence is estimated in Africa. Neurodegenerative disorders are defined by a progressive or self-limiting alteration of neurons implied in specific functional and anatomical functions. It encompasses a various range of clinical disorders from self-limiting to progressive. Focus on public health policies and scientific research is needed to understand the mechanisms to reduce this high prevalence...
2016: Pan African Medical Journal
https://www.readbyqxmd.com/read/27748802/-corrigendum-weighted-gene-co-expression-network-analysis-of-colorectal-cancer-liver-metastasis-genome-sequencing-data-and-screening-of-anti-metastasis-drugs
#3
Bo Gao, Qin Shao, Hani Choudhry, Victoria Marcus, Kung Dong, Jiannis Ragoussis, Zu-Hua Gao
After the publication of the article, the authors noted that the affiliation for Dr Hani Choudhry is wrong. The correct affiliation should be as follows: Bo Gao1, Qin Shao2, Hani Choudhry3, Victoria Marcus2, Kung Dong5, Jiannis Ragoussis4 and Zu-Hua Gao2, 1Department of General Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China; 2Department of Pathology, The Research Institute of McGill University Health Center, Montreal, Québec H4A 3J1, Canada; 3Department of Biochemistry, Faculty of Science, Cancer and Mutagenesis Unit, King Fahd Center for Medical Research, Center of Innovation in Personalized Medicine, King Abdulaziz University, Jeddah, Saudi Arabia; 4McGill University and Genome Quebec Innovation Centre, Montreal, Québec H3B 1S6, Canada; 5Department of Pathology, Beijing Youan Hospital, Capital Medical University, Beijing 100069, P...
October 6, 2016: International Journal of Oncology
https://www.readbyqxmd.com/read/27732795/a-life-investigating-pathways-that-repair-broken-chromosomes
#4
James E Haber
Double-strand breaks (DSBs) pose a severe challenge to genome integrity; consequently, cells have developed efficient mechanisms to repair DSBs through several pathways of homologous recombination and other nonhomologous end-joining processes. Much of our understanding of these pathways has come from the analysis of site-specific DSBs created by the HO endonuclease in the budding yeast Saccharomyces cerevisiae. I was fortunate to get in on the ground floor of analyzing the fate of synchronously induced DSBs through the study of what I coined "in vivo biochemistry...
November 23, 2016: Annual Review of Genetics
https://www.readbyqxmd.com/read/27731337/production-of-valuable-compounds-by-molds-and-yeasts
#5
Arnold L Demain, Evan Martens
We are pleased to dedicate this paper to Dr Julian E Davies. Julian is a giant among microbial biochemists. He began his professional career as an organic chemistry PhD student at Nottingham University, moved on to a postdoctoral fellowship at Columbia University, then became a lecturer at the University of Manchester, followed by a fellowship in microbial biochemistry at Harvard Medical School. In 1965, he studied genetics at the Pasteur Institute, and 2 years later joined the University of Wisconsin in the Department of Biochemistry...
October 12, 2016: Journal of Antibiotics
https://www.readbyqxmd.com/read/27729352/evolution-of-primary-care-databases-in-uk-a-scientometric-analysis-of-research-output
#6
Paraskevas Vezyridis, Stephen Timmons
OBJECTIVE: To identify publication and citation trends, most productive institutions and countries, top journals, most cited articles and authorship networks from articles that used and analysed data from primary care databases (CPRD, THIN, QResearch) of pseudonymised electronic health records (EHRs) in UK. METHODS: Descriptive statistics and scientometric tools were used to analyse a SCOPUS data set of 1891 articles. Open access software was used to extract networks from the data set (Table2Net), visualise and analyse coauthorship networks of scholars and countries (Gephi) and density maps (VOSviewer) of research topics co-occurrence and journal cocitation...
October 11, 2016: BMJ Open
https://www.readbyqxmd.com/read/27617972/robust-yet-fragile-expression-noise-protein-misfolding-and-gene-dosage-in-the-evolution-of-genomes
#7
J Chris Pires, Gavin C Conant
The complex manner in which organisms respond to changes in their gene dosage has long fascinated geneticists. Oddly, although the existence of dominance implies that dosage reductions often have mild phenotypes, extra copies of whole chromosomes (aneuploidy) are generally strongly deleterious. Even more paradoxically, an extra copy of the genome is better tolerated than is aneuploidy. We review the resolution of this paradox, highlighting the roles of biochemistry, protein aggregation, and disruption of cellular microstructure in that explanation...
November 23, 2016: Annual Review of Genetics
https://www.readbyqxmd.com/read/27399670/natural-bioactive-compounds-the-way-shown-by-professor-maurizio-battino-and-his-group-in-an-italian-cutting-edge-laboratory
#8
EDITORIAL
International Journal Of Molecular Sciences Editorial Office
Maurizio Battino, Ph.D., Associate Professor of Biochemistry in the Department of Clinical Sciences, Faculty of Medicine, Università Politecnica delle Marche (Italy), is the Director of the Centre for Health and Nutrition, Universidad Europea del Atlantico (Santander, Spain) and Director of Nutrition and Health projects and Master courses at FUNIBER on-line platform (Barcelona, Spain).[...].
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27270697/learning-and-doing-an-interview-with-bill-wood
#9
William B Wood
THE Genetics Society of America's Elizabeth W. Jones Award for Excellence in Education recognizes significant and sustained impact on genetics education. As well as having made major contributions to biochemistry and developmental genetics, the 2016 awardee William B. Wood has been a pioneer in the reform of science teaching. Wood's leadership has been crucial in several national initiatives and programs, including the development of the influential National Academies Summer institutes on Undergraduate Education in Biology...
June 2016: Genetics
https://www.readbyqxmd.com/read/27270304/chemical-and-biological-studies-of-reveromycin-a
#10
Hiroyuki Osada
The research on antibiotics requires the integration of broad areas, such as microbiology, organic chemistry, biochemistry and pharmacology. It is similar to the field of chemical biology that is recently popular as an approach for drug discovery. When we isolate a new compound from a microorganism, we can pursue the interesting research on chemistry and biology. In this review, I would like to introduce our achievements in relation to reveromycin A.The Journal of Antibiotics advance online publication, 8 June 2016; doi:10...
June 8, 2016: Journal of Antibiotics
https://www.readbyqxmd.com/read/27229373/a-ten-week-biochemistry-lab-project-studying-wild-type-and-mutant-bacterial-alkaline-phosphatase
#11
D Scott Witherow
This work describes a 10-week laboratory project studying wild-type and mutant bacterial alkaline phosphatase, in which students purify, quantitate, and perform kinetic assays on wild-type and selected mutants of the enzyme. Students also perform plasmid DNA purification, digestion, and gel analysis. In addition to simply learning important techniques, students acquire novel biochemical data in their kinetic analysis of mutant enzymes. The experiments are designed to build on students' work from week to week in a way that requires them to apply quantitative analysis and reasoning skills, reinforcing traditional textbook biochemical concepts...
November 12, 2016: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/27182670/british-journal-of-biomedical-science-in-2015-what-have-we-learned
#12
Andrew Blann, Brian Nation
In 2015, the British Journal of Biomedical Science published 47 reports on topics relating to the various disciplines within biomedical science. Of these, the majority were in infection science (15 in microbiology and two in virology) and blood science (seven in biochemistry, four in haematology, three in immunology and one in transplantation), with a smaller number in cellular sciences (four reports) and with one review across disciplines. The present report will summarise key aspects of these publications that are of greatest relevance to laboratory scientists...
2016: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/27129220/introduction-to-biofilms-thematic-minireview-series
#13
Norma M Allewell
The biofilms that many bacteria and fungi produce enable them to form communities, adhere tightly to surfaces, evade host immunity, and resist antibiotics. Pathogenic microorganisms that form biofilms are very difficult to eradicate and thus are a frequent source of life-threatening, hospital-acquired infections. This series of five minireviews from the Journal of Biological Chemistry provides a broad overview of our current understanding of biofilms and the challenges that remain. The structure, biosynthesis, and biological function of the biofilms produced by pathogenic fungi are the subject of the first article, by Sheppard and Howell...
June 10, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27095216/chasing-great-paths-of-helmut-sies-oxidative-stress
#14
Hideyuki J Majima, Hiroko P Indo, Ikuo Nakanishi, Shigeaki Suenaga, Ken-Ichiro Matsumoto, Hirofumi Matsui, Yukiko Minamiyama, Hiroshi Ichikawa, Hsiu-Chuan Yen, Clare L Hawkins, Michael J Davies, Toshihiko Ozawa, Daret K St Clair
Prof. Dr. Helmut Sies is a pioneer of "Oxidative Stress", and has published over 18 papers with the name of "Oxidative Stress" in the title. He has been Editor-in-Chief of the journal "Archives of Biochemistry and Biophysics" for many years, and is a former Editor-in-Chief of the journal "Free Radical Research". He has clarified our understanding of the causes of chronic developing diseases, and has studied antioxidant factors. In this article, importance of "Oxidative Stress" and our mitochondrial oxidative stress studies; roles of mitochondrial ROS, effects of vitamin E and its homologues in oxidative stress-related diseases, effects of antioxidants in vivo and in vitro, and a mitochondrial superoxide theory for oxidative stress diseases and aging are introduced, and some of our interactions with Helmut are described, congratulating and appreciating his great path...
April 1, 2016: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/27095211/the-oxygen-paradox-oxidative-stress-and-ageing
#15
Kelvin J A Davies
Professor Helmut Sies is being lauded in this special issue of Archives of Biochemistry & Biophysics, on the occasion of his retirement as Editor-in-Chief. There is no doubt that Helmut has exerted an enormously positive influence on this journal, the fields of Biochemistry & Biophysics in general, and the areas of free radical and redox biology & medicine in particular. Helmut Sies' many discoveries about peroxide metabolism, glutathione, glutathione peroxidases, singlet oxygen, carotenoids in general and lycopene in particular, and flavonoids, fill the pages of his more than 600 publications...
April 1, 2016: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/27073291/review-time-in-peer-review-quantitative-analysis-and-modelling-of-editorial-workflows
#16
Maciej J Mrowinski, Agata Fronczak, Piotr Fronczak, Olgica Nedic, Marcel Ausloos
In this paper, we undertake a data-driven theoretical investigation of editorial workflows. We analyse a dataset containing information about 58 papers submitted to the Biochemistry and Biotechnology section of the Journal of the Serbian Chemical Society. We separate the peer review process into stages that each paper has to go through and introduce the notion of completion rate - the probability that an invitation sent to a potential reviewer will result in a finished review. Using empirical transition probabilities and probability distributions of the duration of each stage we create a directed weighted network, the analysis of which allows us to obtain the theoretical probability distributions of review time for different classes of reviewers...
2016: Scientometrics
https://www.readbyqxmd.com/read/26898954/metadiscourse-markers-in-biological-research-articles-and-journal-impact-factor-non-native-writers-vs-native-writers
#17
Javad Gholami, Roghayeh Ilghami
Metadiscourse markers (MDMs) are lexical resources that writers employ to organize their discourse and state their stance towards the content or the reader. This study investigated the frequency with which interactive and interactional MDMs were employed in biological research articles (RAs). It also explored the possible relationship between the frequency of these markers and Impact Factor (IF) of journals as an index of quality. Moreover, it aimed at finding out the difference(s) between two groups of authors (Iranian and American) in their use of these markers...
July 8, 2016: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/26864702/bmc-biochemistry-reviewer-acknowledgement-2015
#18
Guangde Tu
The editors of BMC Biochemistry would like to thank all our reviewers who have contributed their time to the journal in Volume 16 (2015).
2016: BMC Biochemistry
https://www.readbyqxmd.com/read/26801683/incorporating-modeling-and-simulations-in-undergraduate-biophysical-chemistry-course-to-promote-understanding-of-structure-dynamics-function-relationships-in-proteins
#19
Sanchita Hati, Sudeep Bhattacharyya
A project-based biophysical chemistry laboratory course, which is offered to the biochemistry and molecular biology majors in their senior year, is described. In this course, the classroom study of the structure-function of biomolecules is integrated with the discovery-guided laboratory study of these molecules using computer modeling and simulations. In particular, modern computational tools are employed to elucidate the relationship between structure, dynamics, and function in proteins. Computer-based laboratory protocols that we introduced in three modules allow students to visualize the secondary, super-secondary, and tertiary structures of proteins, analyze non-covalent interactions in protein-ligand complexes, develop three-dimensional structural models (homology model) for new protein sequences and evaluate their structural qualities, and study proteins' intrinsic dynamics to understand their functions...
March 2016: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/26708189/histochemistry-in-biology-and-medicine-a-message-from-the-citing-journals
#20
REVIEW
Carlo Pellicciari
Especially in recent years, biomedical research has taken advantage of the progress in several disciplines, among which microscopy and histochemistry. To assess the influence of histochemistry in the biomedical field, the articles published during the period 2011-2015 have been selected from different databases and grouped by subject categories: as expected, biological and biomedical studies where histochemistry has been used as a major experimental approach include a wide of basic and applied researches on both humans and other animal or plant organisms...
2015: European Journal of Histochemistry: EJH
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