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https://www.readbyqxmd.com/read/28549059/elimination-diet-and-the-development-of-multiple-tree-nut-allergies
#1
Arnon Elizur, Jennifer B Bollyky, Whitney M Block
BACKGROUNDDespite its high prevalence, relatively little is known about the characteristics of patients with multiple tree-nuts allergies.METHODSPatients (n=60, aged 4-15 years), recruited for a multiple food (tree-nuts, peanut, milk, egg, soy, sesame and wheat) oral immunotherapy (OIT) study, filled a questionnaire on their initial allergy evaluation. Medical records were reviewed. At OIT enrollment (median interval, 7.5 years), patients underwent oral food challenges (OFC) to foods still eliminated.RESULTSThere was significantly less evidence for eliminating tree-nuts compared to other foods, as reflected by lower rate of acute reaction to the offending food, either as the trigger for initial allergy evaluation (5...
May 26, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28542911/changes-in-patient-quality-of-life-during-oral-immunotherapy-for-food-allergy
#2
Na'ama Epstein Rigbi, Michael R Goldberg, Michael B Levy, Liat Nachshon, Keren Golobov, Arnon Elizur
BACKGROUND: Quality of life is (QOL) impaired in patients with food allergy and improves following oral immunotherapy (OIT). However, the treatment itself is prolonged and demanding. We examined changes in patient QOL during OIT for food allergy. METHODS: The FAQLQ-PF was administered to children aged 4-12 years undergoing OIT for milk, peanut or egg allergy, at the beginning and after 4 months of treatment. Patients were categorized as improved, unchanged, or diminished FAQLQ-PF (>0...
May 22, 2017: Allergy
https://www.readbyqxmd.com/read/28521317/mechanisms-of-tolerance-induction
#3
Anna Nowak-Węgrzyn, Pantipa Chatchatee
Food allergy results from failure in oral tolerance that usually occurs in infancy or early childhood. Exposure to peanut and hen's egg via the inflamed and disrupted epithelial barrier in children with severe atopic dermatitis is a risk factor for the development of allergy to these foods and supports the hypothesis that epicutaneous exposure in the absence of oral feeding is an important pathway of allergic IgE sensitization in infants. In recent years, the collective evidence has pointed toward the protective effect of an early feeding with peanut and egg in children with eczema, taking advantage of the pathways underlying oral tolerance to counteract epicutaneous exposure...
2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/28521316/introduction-of-complementary-foods-to-infants
#4
Christina West
While earlier food allergy prevention strategies implemented avoidance of allergenic foods in infancy, the current paradigm is shifting from avoidance to controlled exposure. This review focuses on the outcome of recent randomized controlled trials, which have examined the early introduction of allergenic foods for allergy prevention, and discusses the implementation of results in clinical practice. In infants at high risk of allergic disease, there is now direct evidence that regular early peanut consumption will reduce the prevalence of peanut allergy, compared to avoidance...
2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/28514997/the-prevalence-of-food-allergy-and-other-allergic-diseases-in-early-childhood-in-a-population-based-study-healthnuts-age-4-year-follow-up
#5
Rachel L Peters, Jennifer J Koplin, Lyle C Gurrin, Shyamali C Dharmage, Melissa Wake, Anne-Louise Ponsonby, Mimi L K Tang, Adrian J Lowe, Melanie Matheson, Terence Dwyer, Katrina J Allen
BACKGROUND: The HealthNuts study previously reported interim prevalence data showing the highest prevalence of challenge-confirmed food allergy in infants internationally. However, population-derived prevalence data on challenge-confirmed food allergy and other allergic diseases in preschool-aged children remain sparse. OBJECTIVE: This study aimed to report the updated prevalence of food allergy at age 1 year from the whole cohort, and to report the prevalence of food allergy, asthma, eczema, and allergic rhinitis at age 4 years...
April 25, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28509782/an-update-on-the-impact-of-food-allergy-on-anxiety-and-quality-of-life
#6
Marcus S Shaker, Jonathan Schwartz, Morgan Ferguson
PURPOSE OF REVIEW: Food allergies have become more common, and management involves dietary avoidance that can impair quality of life. Patients and families must manage the daily risk of anaphylaxis at each meal. The purpose of this review is to describe the impact of food allergies on quality of life and to provide an update on new developments in food allergy management, particularly peanut allergy. RECENT FINDINGS: Food allergy requires careful avoidance of common and ubiquitous dietary allergens...
May 13, 2017: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/28509626/custom-compounded-bioidentical-hormone-therapy-why-so-popular-despite-potential-harm-the-case-against-routine-use
#7
M L'Hermite
Wide rejection of conventional hormone therapy (HT) after the initial publication of the Women's Health Initiative (WHI) led to unjustified use of custom-compounded bioidentical hormones. In the USA, it became an unregulated drug manufacturer industry in disguise, without proper control and making false claims and misleading advertisements. Manufacturing quality is not ensured. Unspecific harm from compounding has occurred on a large scale, such as deaths from infected products and end-stage renal failure plus carcinoma due to confusion between different Chinese herbs...
June 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28479331/forkhead-box-protein-3-foxp3-demethylation-is-associated-with-tolerance-induction-in-peanut-induced-intestinal-allergy
#8
Meiqin Wang, Ivana V Yang, Elizabeth J Davidson, Anthony Joetham, Katsuyuki Takeda, Brian P O'Connor, Erwin W Gelfand
BACKGROUND: Regulatory T cells (Tregs) play an essential role in the maintenance of immune homeostasis in allergic diseases. OBJECTIVES: To define the mechanisms underlying induction of tolerance to peanut protein and prevention of the development of peanut allergy. METHODS: High or low doses of peanut extract (PE) were administered to pups every day for 2 weeks prior to peanut sensitization and challenge. Following challenge, symptoms, Treg numbers, FoxP3, Th2, Th17 cytokine and TGFβ expression in mesenteric lymph node (MLN) CD4(+) T cells and in jejunum were monitored...
May 4, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28470372/food-allergy-in-south-africa
#9
REVIEW
Claudia L Gray
PURPOSE OF THE REVIEW: Whilst food allergy seems to have increased significantly in many developed countries in the past few decades, quality data on the burden of food allergy in many developing countries is scanty. Until recently, South Africa had a dearth of robustly designed food allergy studies. This article summarizes some of the recent research and observations regarding food allergy from the South African setting. RECENT FINDINGS: South Africa has recently seen two important food allergy prevalence studies in selected and unselected populations...
June 2017: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/28461822/ige-mediated-food-allergies-in-children-prevalence-triggers-and-management
#10
REVIEW
Sooyoung Lee
Food allergy (FA) is a serious health problem, and severe FA such as food-induced anaphylaxis can often be life threatening. The incidence of FA has been increasing especially in children. They usually develop early in life and affect up to 10% of children. The 2 most common food allergens worldwide are milk and eggs, while the third one varies depending on the countries: peanuts in the United States and Switzerland, wheat in Germany and Japan, tree nuts in Spain, sesame in Israel, and walnuts in Korea. These common food allergens are different and difficult to identify because of differing study methodologies, population, geography, age, and dietary exposure patterns...
April 2017: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/28449793/addendum-guidelines-for-the-prevention-of-peanut-allergy-in-the-united-states-summary-of-the-national-institute-of-allergy-and-infectious-diseases-sponsored-expert-panel
#11
Alkis Togias, Susan F Cooper, Maria L Acebal, Amal Assa'ad, James R Baker, Lisa A Beck, Julie Block, Carol Byrd-Bredbenner, Edmond S Chan, Lawrence F Eichenfield, David M Fleischer, George J Fuchs, Glenn T Furuta, Matthew J Greenhawt, Ruchi S Gupta, Michele Habich, Stacie M Jones, Kari Keaton, Antonella Muraro, Marshall Plaut, Lanny J Rosenwasser, Daniel Rotrosen, Hugh A Sampson, Lynda C Schneider, Scott H Sicherer, Robert Sidbury, Jonathan Spergel, David R Stukus, Carina Venter, Joshua A Boyce
No abstract text is available yet for this article.
May 2017: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/28449792/academy-approves-niaid-addendum-guidelines-for-the-prevention-of-peanut-allergy
#12
Lisa Moloney, Donna L Wickstrom, Marsha Schofield, Rosa K Hand
No abstract text is available yet for this article.
May 2017: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/28441989/ara-h2-levels-in-dust-from-homes-of-individuals-with-peanut-allergy-and-individuals-with-peanut-tolerance
#13
Jodi Shroba, Charles Barnes, Maya Nanda, Chitra Dinakar, Christina Ciaccio
BACKGROUND: Approximately 1% of the U.S. population has a peanut allergy. Previous studies that measured peanut protein in house dust support the hypothesis that household peanut consumption may lead to clinical sensitization through transdermal exposure. OBJECTIVE: The aim of this pilot study was to characterize Ara h2 levels in house dust from homes with and without individuals with peanut allergy. METHODS: Household dust was obtained from homes with an individual with peanut allergy and from homes with no individual with peanut allergy...
May 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28425254/wheezing-asthma-and-atopy-in-premature-infants-at-2-years-of-age
#14
Sevim Ünal, Ayşenur Kaya, Leyla Bilgin, Emine Misirlioğlu, Can Naci Kocabaş
BACKGROUND/AIM: We aimed to evaluate wheezing, bronchial asthma (BA), and atopy in premature infants at 2 years of age via a cross-sectional study. MATERIALS AND METHODS: Premature infants at <37 weeks of gestational age (GA) were assessed for atopy by skin-prick test and serum immunoglobulin E level at 2 years of age. The family's and infant's histories of allergy, BA, atopy, and wheezing were obtained by questionnaire and from hospital records. RESULTS: There were 98 infants, with mean birth weight (BW) 1517...
April 18, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28423454/uk-neqas-survey-of-allergen-component-testing-across-the-united-kingdom-and-other-european-countries
#15
R Saleem, C Keymer, D Patel, W Egner, A W Rowbottom
The clinical utility of molecular diagnostic approaches in allergy investigation is being recognized increasingly to play a significant role in the management of allergic patients. Determining the sensitization pattern, which is best achieved through the use of component resolved diagnostics (CRD), allows effective risk stratification, appropriate treatment and patient selection for immunotherapy. In order to assess the diagnostic service provisions for in-vitro allergy testing across Europe, a survey was carried out via the total immunoglobulin (Ig)E and specific IgE external quality assurance schemes run by UK National External Quality Assessment Service (NEQAS) Immunology, Immunochemistry and Allergy...
June 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28421513/primary-prevention-of-food-allergy
#16
REVIEW
Matthew J Greenhawt, David M Fleischer
Food allergy is estimated to affect approximately 8% of children in the USA. This is a disease without any known treatment or cure and, for some, a disease that can be quite severe, even life-threatening. While recent advances in potential treatment have made remarkable strides, with two food-targeted immunotherapy products now in phase III trials, perhaps the biggest gains in the field have come in the advent of potential preventative strategies to avoid the development of food allergy in high-risk individuals...
April 2017: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/28397379/b-fahf-2-plus-oral-immunotherapy-oit-is-safer-and-more-effective-than-oit-alone-in-a-murine-model-of-concurrent-peanut-tree-nut-allergy
#17
Kamal D Srivastava, Ying Song, Nan Yang, Changda Liu, Ilan E Goldberg, Anna Nowak-Węgrzyn, Hugh A Sampson, Xiu-Min Li
BACKGROUND: Concurrent sensitization to peanut (PN) and tree nuts (TN), the most dangerous food allergies, is common. Current oral immunotherapy (OIT) is not fully satisfactory. OBJECTIVE: To determine if the herbal formula B-FAHF-2 (BF2) ameliorates PN/TN OIT adverse reactions and enhances persistence of a tolerant state. METHODS: Concurrently sensitized peanut, walnut (WN) and cashew (CSH) allergic mice received 1 day PN/WN/CSH rush OIT plus 3 weeks of maintenance dosing, with or without 3-weeks prior and 3-weeks BF2 co-treatment...
April 11, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28359600/characteristics-of-tree-nut-challenges-in-tree-nut-allergic-and-tree-nut-sensitized-individuals
#18
Christopher Couch, Tim Franxman, Matthew Greenhawt
BACKGROUND: Characteristics and outcomes of tree nut (TN) oral food challenges (OFCs) in patients with TN allergy or sensitization alone are poorly studied. OBJECTIVE: To determine the relation between TN sensitization levels and OFC outcomes. METHODS: Open TN OFCs performed from 2007 through 2015 at a referral center were analyzed to compare outcome based on skin prick test (SPT) wheal size, food-specific immunoglobulin E (sIgE), peanut co-allergy, and TN sensitization only vs TN allergy with sensitization to other TNs...
May 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28351786/association-of-clinical-reactivity-with-sensitization-to-allergen-components-in-multifood-allergic-children
#19
Sandra Andorf, Magnus P Borres, Whitney Block, Dana Tupa, Jennifer B Bollyky, Vanitha Sampath, Arnon Elizur, Jonas Lidholm, Joseph E Jones, Stephen J Galli, Rebecca S Chinthrajah, Kari C Nadeau
BACKGROUND: Thirty percent of children with food allergies have multiple simultaneous allergies; however, the features of these multiple allergies are not well characterized serologically or clinically. OBJECTIVE: We comprehensively evaluated 60 multifood-allergic patients by measuring serum IgE to key allergen components, evaluating clinical histories and medication use, performing skin tests, and conducting double-blind, placebo-controlled food challenges (DBPCFCs)...
March 25, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28347736/impact-of-school-peanut-free-policies-on-epinephrine-administration
#20
Lisa M Bartnikas, Michelle F Huffaker, William J Sheehan, Watcharoot Kanchongkittiphon, Carter R Petty, Robert Leibowitz, Marissa Hauptman, Michael C Young, Wanda Phipatanakul
BACKGROUND: Children with food allergies spend a large proportion of time in school but characteristics of allergic reactions in schools are not well studied. Some schools self-designate as peanut-free or have peanut-free areas, but the impact of policies on clinical outcomes has not been evaluated. OBJECTIVE: We sought to determine the effect of peanut-free policies on rates of epinephrine administration for allergic reactions in Massachusetts public schools. METHODS: In this retrospective study, we analyzed (1) rates of epinephrine administration in all Massachusetts public schools and (2) Massachusetts public school nurse survey reports of school peanut-free policies from 2006 to 2011 and whether schools self-designated as "peanut-free" based on policies...
March 25, 2017: Journal of Allergy and Clinical Immunology
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