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Cathespin D and migration

Krishna Kumar Veeravalli, Chandramu Chetty, Shivani Ponnala, Christopher S Gondi, Sajani S Lakka, Daniel Fassett, Jeffrey D Klopfenstein, Dzung H Dinh, Meena Gujrati, Jasti S Rao
BACKGROUND: Involvement of MMP-9, uPAR and cathepsin B in adhesion, migration, invasion, proliferation, metastasis and tumor growth has been well established. In the present study, MMP-9, uPAR and cathepsin B genes were downregulated in glioma xenograft cells using shRNA plasmid constructs and we evaluated the involvement of integrins and changes in their adhesion, migration and invasive potential. METHODOLOGY/PRINCIPAL FINDINGS: MMP-9, uPAR and cathepsin B single shRNA plasmid constructs were used to downregulate these molecules in xenograft cells...
July 15, 2010: PloS One
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