Wenkang Jiang, Huina Luo, Mingming Zhao, Quanbao Fan, Cailing Ye, Xingying Li, Jing He, Jianyi Lai, Shi He, Wojun Chen, Weihang Xian, Shengfeng Chen, Zhisheng Chen, Dongsheng Li, Ruiai Chen, Bingyun Wang
BACKGROUND: Traumatic brain injury (TBI) is a common condition in veterinary medicine that is difficult to manage.Veterinary regenerative therapy based on adipose mesenchymal stem cells seem to be an effective strategy for the treatment of traumatic brain injury. In this study, we evaluated therapeutic efficacy of canine Adipose-derived mesenchymal stem cells (AD-MSCs)in a rat TBI model, in terms of improved nerve function and anti-neuroinflammation. RESULTS: Canine AD-MSCs promoted neural functional recovery, reduced neuronal apoptosis, and inhibited the activation of microglia and astrocytes in TBI rats...
March 18, 2024: BMC Veterinary Research