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https://www.readbyqxmd.com/read/28227697/simultaneous-evaluation-of-prepulse-inhibition-with-emg-and-eeg-using-advanced-artifact-removal-techniques
#1
Francisco J Fraga, Claudemiro V Noya, Maria I Zimiani, Milton A Avila, Rosana Shuhama, Cristina M Del-Ben, Paulo R Menezes, Rodrigo S Martin, Cristiane Salum, Francisco J Fraga, Claudemiro V Noya, Maria I Zimiani, Milton A Avila, Rosana Shuhama, Cristina M Del-Ben, Paulo R Menezes, Rodrigo S Martin, Cristiane Salum, Francisco J Fraga, Paulo R Menezes, Claudemiro V Noya, Rosana Shuhama, Milton A Avila, Cristina M Del-Ben, Cristiane Salum, Rodrigo S Martin, Maria I Zimiani
Prepulse inhibition (PPI) consists of a reduction of the acoustic startle reflex (SR) magnitude (measured with EMG) when a startling stimulus is preceded by a non-startling one. This behavior has been extensively investigated in studies related to schizophrenia, since sensory-motor deficit plays a central role in its pathophysiology. However, the same auditory stimuli that trigger the SR also provoke intense auditory evoked responses (AEP), which can be measured with EEG. Comparing these two types of responses, acquired simultaneously, is a great opportunity to investigate the dependence and interdependence of their neural pathways...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227408/structural-brain-network-analysis-in-schizophrenia-using-minimum-spanning-tree
#2
Ali Anjomshoa, Mahsa Dolatshahi, Fatemeh Amirkhani, Farzaneh Rahmani, Mehdi M Mirbagheri, Mohammad Hadi Aarabi, Ali Anjomshoa, Mahsa Dolatshahi, Fatemeh Amirkhani, Farzaneh Rahmani, Mehdi M Mirbagheri, Mohammad Hadi Aarabi, Mehdi M Mirbagheri, Mahsa Dolatshahi, Ali Anjomshoa, Farzaneh Rahmani, Fatemeh Amirkhani, Mohammad Hadi Aarabi
Schizophrenia is a mental disorder in which functional and structural brain networks are disrupted. Classical network analysis has been used by many researchers to quantify brain networks and to study the network changes in schizophrenia, but unfortunately metrics used in this classical method highly depend on the networks' density and weight; the comparisons made by this method are biased. The minimum spanning tree (MST) is an alternative method to solve this problem, but its usefulness in studying the schizophrenic brain network has not been examined yet...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227396/supervised-multimodal-fusion-and-its-application-in-searching-joint-neuromarkers-of-working-memory-deficits-in-schizophrenia
#3
Shile Qi, Vince D Calhoun, Theo G M van Erp, Eswar Damaraju, Juan Bustillo, Yuhui Du, Jessica A Turner, Daniel H Mathalon, Judith M Ford, James Voyvodic, Bryon A Mueller, Aysenil Belger, Sarah Mc Ewen, Steven G Potkin, Adrian Preda, F Birn, Tianzi Jiang, Jing Sui, Shile Qi, Vince D Calhoun, Theo G M van Erp, Eswar Damaraju, Juan Bustillo, Yuhui Du, Jessica A Turner, Daniel H Mathalon, Judith M Ford, James Voyvodic, Bryon A Mueller, Aysenil Belger, Sarah McEwen, Steven G Potkin, Adrian Preda, F Birn, Tianzi Jiang, Jing Sui
Multimodal fusion is an effective approach to better understand brain disease. To date, most current fusion approaches are unsupervised; there is need for a multivariate method that can adopt prior information to guide multimodal fusion. Here we proposed a novel supervised fusion model, called "MCCAR+jICA", which enables both identification of multimodal co-alterations and linking the covarying brain regions with a specific reference signal, e.g., cognitive scores. The proposed method has been validated on both simulated and real human brain data...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227324/analysis-of-the-non-stationarity-of-neural-activity-during-an-auditory-oddball-task-in-schizophrenia
#4
P Nunez, J Poza, J Gomez-Pilar, A Bachiller, C Gomez, A Lubeiro, V Molina, R Hornero, P Nunez, J Poza, J Gomez-Pilar, A Bachiller, C Gomez, A Lubeiro, V Molina, R Hornero, J Gomez-Pilar, A Bachiller, C Gomez, J Poza, P Nunez, A Lubeiro, V Molina, R Hornero
The aim of this study was to characterize brain dynamics during an auditory oddball task. For this purpose, a measure of the non-stationarity of a given time-frequency representation (TFR) was applied to electroencephalographic (EEG) signals. EEG activity was acquired from 20 schizophrenic (SCH) patients and 20 healthy controls while they underwent a three-stimulus auditory oddball task. The Degree of Stationarity (DS), a measure of the non-stationarity of the TFR, was computed using the continuous wavelet transform...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227225/integration-of-snps-fmri-methylation-data-with-sparse-multi-cca-for-schizophrenia-study
#5
Wenxing Hu, Dongdong Lin, Vince D Calhoun, Yu-Ping Wang, Wenxing Hu, Dongdong Lin, Vince D Calhoun, Yu-Ping Wang, Vince D Calhoun, Yu-Ping Wang, Wenxing Hu, Dongdong Lin
Schizophrenia (SZ) is a complex mental disorder associated with genetic variations, brain development and activities, and environmental factors. There is an increasing interest in combining genetic, epigenetic and neuroimaging datasets to explore different level of biomarkers for the correlation and interaction between these diverse factors. Sparse Multi-Canonical Correlation Analysis (sMCCA) is a powerful tool that can analyze the correlation of three or more datasets. In this paper, we propose the sMCCA model for imaging genomics study...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227010/differentiating-facial-incongruity-and-flatness-in-schizophrenia-using-structured-light-camera-data
#6
Talia Tron, Abraham Peled, Alexander Grinsphoon, Daphna Weinshall, Talia Tron, Abraham Peled, Alexander Grinsphoon, Daphna Weinshall, Alexander Grinsphoon, Abraham Peled, Talia Tron
Incongruity between emotional experience and its outwardly expression is one of the prominent symptoms in schizophrenia. Though widely reported and used in clinical evaluation, this symptom is inadequately defined in the literature and may be confused with mere affect flattening. In this study we used structured-light depth camera and dedicated software to automatically measure facial activity of schizophrenia patients and healthy individuals during an emotionally evocative task. We defined novel measures for the congruence of emotional experience and emotional expression and for Flat Affect, compared them between patients and controls, and examined their consistency with clinical evaluation...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226777/predicting-schizophrenia-by-fusing-networks-from-snps-dna-methylation-and-fmri-data
#7
Su-Ping Deng, Dongdong Lin, Vince D Calhoun, Yu-Ping Wang, Su-Ping Deng, Dongdong Lin, Vince D Calhoun, Yu-Ping Wang, Vince D Calhoun, Su-Ping Deng, Yu-Ping Wang, Dongdong Lin
In order to comprehensively utilize complementary information from multiple types of data for better disease diagnosis, in this study, we applied a network fusion based approach to integrating three types of data including genetic, epigenetic and neuroimaging data from a study of schizophrenia patients (SCZ). A network is a map of interactions, which contributes to investigating the connectivity of components or links between sub-units. We exploited the potential of using networks as features for discriminating SCZ from healthy controls...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226701/an-image-resolution-perspective-on-functional-activity-mapping
#8
Keith Dillon, Yu-Ping Wang, Keith Dillon, Yu-Ping Wang, Yu-Ping Wang, Keith Dillon
In this paper we apply techniques for numerical estimation of system resolution from imaging, to the regression problem of relating biological data to phenotypes. Our approach can be viewed as an extension of Backus-Gilbert theory, which attempts to find the most concentrated estimator that may be reliably computed in an inverse problem. Applied to a regression model, we estimate a minimal combination of collinear variables that may be found in a predictor, which gives a robust multivariable estimate of the network relationships in the data...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226594/novel-measure-of-the-weigh-distribution-balance-on-the-brain-network-graph-complexity-applied-to-schizophrenia
#9
J Gomez-Pilar, J Poza, A Bachiller, P Nunez, C Gomez, A Lubeiro, V Molina, R Hornero, J Gomez-Pilar, J Poza, A Bachiller, P Nunez, C Gomez, A Lubeiro, V Molina, R Hornero, J Gomez-Pilar, A Bachiller, C Gomez, J Poza, P Nunez, A Lubeiro, V Molina, R Hornero
The aim of this study was to assess brain complexity dynamics in schizophrenia (SCH) patients during an auditory oddball task. For this task, we applied a novel graph measure based on the balance of the node weights distribution. Previous studies applied complexity parameters that were strongly dependent on network topology. This could bias the results, as well as making correction techniques, such as surrogating process, necessary. In the present study, we applied a novel graph complexity measure derived from the information theory: Shannon Graph Complexity (SGC)...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226318/existential-orientation-on-the-phenomenology-of-values-attitudes-and-worldviews-in-schizophrenia-ancillary-article-to-eawe-domain-6
#10
Elizabeth Pienkos, Louis Sass
Since the appearance of schizophrenia as a distinct diagnosis, various researchers and clinicians, particularly those in the phenomenological and existential tradition, have noted the unique contribution of attitudinal and characterological factors to the illness. There has been a notable lack of attention paid to these features in most recent research on the disorder; still, understanding the values, attitudes, and worldviews - what might be termed the "existential orientation" - of persons with schizophrenia may be essential for comprehending the illness and developing effective approaches to treatment...
February 23, 2017: Psychopathology
https://www.readbyqxmd.com/read/28226265/alterations-of-ubiquitin-related-proteins-in-the-pathology-and-development-of-schizophrenia-evidence-from-human-and-animal-studies
#11
Jessica L Andrews, Frederic J Goodfellow, Natalie Matosin, Mollie K Snelling, Kelly A Newell, Xu-Feng Huang, Francesca Fernandez-Enright
Gene expression analyses in post-mortem schizophrenia brains suggest that a number of ubiquitin proteasome system (UPS) genes are associated with schizophrenia; however the status of UPS proteins in the schizophrenia brain is largely unknown. Ubiquitin related proteins are inherently involved in memory, neuronal survival and morphology, which are processes implicated in neurodevelopmental disorders such as schizophrenia. We examined levels of five UPS proteins (Protein Inhibitor of Activated STAT2 [PIAS2], F-Box and Leucine rich repeat protein 21 [FBXL21], Mouse Double Minute 2 homolog [MDM2], Ubiquitin Carboxyl-Terminal Hydrolase-L1 [UCHL1] and Ubiquitin Conjugating Enzyme E2D1 [UBE2D1]) involved in these neuronal processes, within the dorsolateral prefrontal cortex of post-mortem schizophrenia subjects and matched controls (n = 30/group), in addition to across neurodevelopmental time-points (juvenile, adolescent and adult stages of life), utilizing a well-established neurodevelopmental phencyclidine (PCP) animal model of schizophrenia...
January 18, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28226264/leukocyte-telomere-length-in-hispanic-schizophrenia-patients-under-treatment-with-olanzapine
#12
Nancy Monroy-Jaramillo, Yaneth Rodríguez-Agudelo, Luis Carlos Aviña-Cervantes, David L Roberts, Dawn I Velligan, Consuelo Walss-Bass
Different lines of evidence indicate that patients with schizophrenia (SZ) exhibit accelerated aging. Leukocyte telomere length (TL), an aging marker, is associated with age-related and chronic pathologies, including schizophrenia. We analyzed leukocyte TL in 170 SZ patients of Hispanic ancestry grouped based on antipsychotic treatment, compared to 126 matched controls. The group under treatment with atypical antipsychotics was further subdivided according to the risk of medication to cause metabolic syndrome (MetS)...
February 10, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28225749/effects-of-exercise-on-serum-triglycerides-and-symptoms-of-schizophrenia
#13
David D Kim, Donna J Lang, Darren E R Warburton, Alasdair M Barr, Geoffrey N Smith, Allen E Thornton, Randall F White, William G Honer, Ric M Procyshyn
No abstract text is available yet for this article.
April 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28225745/predictors-of-nonhospitalization-and-functional-response-in-clozapine-treatment-a-nationwide-population-based-cohort-study
#14
Ole Köhler-Forsberg, Henriette T Horsdal, Sophie E Legge, James H MacCabe, Christiane Gasse
BACKGROUND: Clozapine remains the only evidence-based treatment for treatment-resistant schizophrenia, and prediction of clozapine response is important in developing stratified treatment. We studied potential predictors of clozapine response, applying functional assessments as well as service use. PROCEDURES: We performed a nationwide cohort study among all individuals diagnosed with schizophrenia in Denmark after 1995 (age, ≥18 years) who initiated clozapine treatment between 2004 and 2011 with a Global Assessment of Functioning (GAF-F) score registered at clozapine initiation...
April 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28225521/sex-differences-in-body-mass-index-and-obesity-in-chinese-patients-with-chronic-schizophrenia-erratum
#15
(no author information available yet)
No abstract text is available yet for this article.
April 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28225484/association-between-erbb4-single-nucleotide-polymorphisms-and-susceptibility-to-schizophrenia-a-meta-analysis-of-case-control-studies
#16
Yanguo Feng, Dejun Cheng, Chaofeng Zhang, Yuchun Li, Zhiying Zhang, Juan Wang, Xiao Feng
BACKGROUND: Accumulating studies have reported inconsistent association between ErbB4 single nucleotide polymorphisms (SNPs) and predisposition to schizophrenia. To better interpret this issue, here we conducted a meta-analysis using published case-control studies. METHODS: We conducted a systematic search of MEDLINE (Pubmed), Embase (Ovid), Web of Science (Thomson-Reuters) to identify relevant references. The association between ErbB4 SNPs and schizophrenia was assessed by odds ratios (ORs) and 95% confidence intervals (CIs)...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28225439/tachycardia-in-patients-treated-with-clozapine-versus-antipsychotic-long-acting-injections
#17
Björn M Nilsson, Oscar Edström, Leif Lindström, Petter Wernegren, Robert Bodén
Tachycardia is a known adverse effect during clozapine treatment. However, prevalence reported differs widely between studies and hitherto there are no studies comparing clozapine-treated patients with a similar control group. The present study was carried out to assess the prevalence of tachycardia in patients treated with clozapine and antipsychotic long-acting injections (LAI). Data on heart rate (HR), concomitant medication, and relevant anthropometric and laboratory measurements were collected for all clozapine-treated patients (n=174) in a defined catchment area and compared with data on patients treated with LAI (n=87)...
February 20, 2017: International Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28225304/column-switching-uhplc-ms-ms-with-restricted-access-material-for-the-determination-of-cns-drugs-in-plasma-samples
#18
Vinicius Ricardo Acquaro, Diego Soares Domingues, Maria Eugênia Costa Queiroz
BACKGROUND: Polypharmacy is a common practice in schizophrenia. Consequently, therapeutic drug monitoring is usually adopted to maintain the concentrations of the drugs in the plasma within a targeted therapeutic range, to maximize therapeutic efficiency and to diminish adverse side effects. METHODOLOGY: This study reports on a column switching UHPLC-MS/MS method to determine psychotropic drugs in plasma samples simultaneously. RESULTS: The method was linear from 0...
February 22, 2017: Bioanalysis
https://www.readbyqxmd.com/read/28224285/abnormal-effective-connectivity-in-the-brain-is-involved-in-auditory-verbal-hallucinations-in-schizophrenia
#19
Baojuan Li, Long-Biao Cui, Yi-Bin Xi, Karl J Friston, Fan Guo, Hua-Ning Wang, Lin-Chuan Zhang, Yuan-Han Bai, Qing-Rong Tan, Hong Yin, Hongbing Lu
Information flow among auditory and language processing-related regions implicated in the pathophysiology of auditory verbal hallucinations (AVHs) in schizophrenia (SZ) remains unclear. In this study, we used stochastic dynamic causal modeling (sDCM) to quantify connections among the left dorsolateral prefrontal cortex (inner speech monitoring), auditory cortex (auditory processing), hippocampus (memory retrieval), thalamus (information filtering), and Broca's area (language production) in 17 first-episode drug-naïve SZ patients with AVHs, 15 without AVHs, and 19 healthy controls using resting-state functional magnetic resonance imaging...
February 21, 2017: Neuroscience Bulletin
https://www.readbyqxmd.com/read/28223982/mouse-model-of-neurological-complications-resulting-from-encephalitic-alphavirus-infection
#20
Shannon E Ronca, Jeanon Smith, Takaaki Koma, Magda M Miller, Nadezhda Yun, Kelly T Dineley, Slobodan Paessler
Long-term neurological complications, termed sequelae, can result from viral encephalitis, which are not well understood. In human survivors, alphavirus encephalitis can cause severe neurobehavioral changes, in the most extreme cases, a schizophrenic-like syndrome. In the present study, we aimed to adapt an animal model of alphavirus infection survival to study the development of these long-term neurological complications. Upon low-dose infection of wild-type C57B/6 mice, asymptomatic and symptomatic groups were established and compared to mock-infected mice to measure general health and baseline neurological function, including the acoustic startle response and prepulse inhibition paradigm...
2017: Frontiers in Microbiology
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