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https://www.readbyqxmd.com/read/28346888/oxidative-and-nitrosative-stress-biomarkers-in-chronic-schizophrenia
#1
Karine Maria Boll, Cristiano Noto, Kamila Landucci Bonifácio, Chiara Cristina Bortolasci, Ary Gadelha, Rodrigo Affonseca Bressan, Décio Sabbatini Barbosa, Michael Maes, Estefania Gastaldello Moreira
There is evidence that the acute phase of schizophrenia (SCZ) is accompanied by specific changes in oxidative and nitrosative stress (O&NS) biomarkers. There are, however, no firm data regarding these biomarkers in chronic SCZ. Therefore, this study aimed to delineate O&NS biomarkers in patients with chronic SCZ. 125 outpatients with SCZ and 118 controls were enrolled. The markers included lipid hydroperoxides (LOOH), advanced oxidation protein products (AOPP), nitric oxide metabolites (NOx), total radical-trapping antioxidant parameter (TRAP) and paraoxonase 1 (PON-1) activity...
March 21, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28346773/noninterventional-naturalistic-retrospective-study-to-describe-prescription-patterns-of-long-acting-injectable-antipsychotics-and-the-impact-of-introducing-a-new-atypical-antipsychotic-in-the-spanish-province-of-tarragona-catchment-area
#2
Ana M Gaviria, José Franco, Guillem Rico, Gerard Muntané, Cristina Sáez, Vanessa Sánchez-Gistau, Joan de Pablo, Elisabet Vilella
Background: We studied the patterns and predictors of long-acting injectable (LAI) antipsychotic (AP) use in the treatment of schizophrenia and the effect of introducing a new LAI (paliperidone palmitate [paliperidone-LAI]) in the Spanish province of Tarragona. Methods: This noninterventional, naturalistic, retrospective study included electronic medical record data from a large population-based database of 1,646 patients who were diagnosed with schizophrenia according to ICD-10 criteria and treated between January 2011 and December 2013...
March 23, 2017: Primary Care Companion to CNS Disorders
https://www.readbyqxmd.com/read/28346630/beyond-schizophrenia-living-and-working-with-a-serious-mental-illness
#3
Matt Martin
No abstract text is available yet for this article.
March 2017: Family Medicine
https://www.readbyqxmd.com/read/28346060/stem-cell-derived-neurons-in-the-development-of-targeted-treatment-for-schizophrenia-and-bipolar-disorder
#4
Bradley Watmuff, Bangyan Liu, Rakesh Karmacharya
The recent advent of induced pluripotent stem cells has enabled the study of patient-specific and disease-related neurons in vitro and has facilitated new directions of inquiry into disease mechanisms. With these approaches, we now have the possibility of correlating ex vivo cellular phenotypes with individual patient response to treatment and/or side effects, which makes targeted treatments for schizophrenia and bipolar disorder a distinct prospect in the coming years. Here, we briefly review the current state of stem cell-based models and explore studies that are providing new insights into the disease biology of schizophrenia and bipolar disorder, which are laying the foundations for the development of novel targeted therapies...
March 27, 2017: Pharmacogenomics
https://www.readbyqxmd.com/read/28346041/enhancing-tolerability-of-a-measure-of-social-perception-in-schizophrenia-comparison-of-short-and-long-norwegian-versions-of-the-relationships-across-domains-test
#5
Anja Vaskinn, Alan P Fiske, Michael F Green
INTRODUCTION: Relationship perception focuses on social interactions, is reduced in schizophrenia and is related to daily functioning. It can be assessed with the Relationships Across Domains (RAD) test, built on Relational Models Theory which states that people use four relational models to interpret social interaction. RAD is time consuming, low on tolerability and only used in English-speaking countries. We evaluated the psychometric properties of a translated, abbreviated Norwegian version...
March 27, 2017: Cognitive Neuropsychiatry
https://www.readbyqxmd.com/read/28345513/-schizophrenia-and-oral-health
#6
M Moullan, F Denis
Mental health is an essential component of general health. Schizophrenia is a severe and chronic mental illness that affects higher brain functions. It is characterized by the presence of a mental dissociation, dampened or inappropriate affects, hallucinations and delirium. Schizophrenia has also a negative impact on oral health. As schizophrenia affects 1% of the population, every practitioner concerned with oral sphere will be confronted one day or another with a patient suffering from this disease. It is therefore important to acquire essential notions...
March 24, 2017: J Stomatol Oral Maxillofac Surg
https://www.readbyqxmd.com/read/28344764/atypical-antipsychotics-recent-research-findings-and-applications-to-clinical-practice-proceedings-of-a-symposium-presented-at-the-29th-annual-european-college-of-neuropsychopharmacology-congress-19-september-2016-vienna-austria
#7
REVIEW
Robin Murray, Christoph U Correll, Gavin P Reynolds, David Taylor
Available evidence suggests that second-generation atypical antipsychotics are broadly similar to first-generation agents in terms of their efficacy, but may have a more favourable tolerability profile, primarily by being less likely to cause extrapyramidal symptoms. However, atypical antipsychotics are variably associated with disturbances in the cardiometabolic arena, including increased body weight and the development of metabolic syndrome, which may reflect differences in their receptor binding profiles...
March 2017: Therapeutic Advances in Psychopharmacology
https://www.readbyqxmd.com/read/28344592/dysbindin-deficiency-modifies-the-expression-of-gaba-neuron-and-ion-permeation-transcripts-in-the-developing-hippocampus
#8
Jennifer Larimore, Stephanie A Zlatic, Miranda Arnold, Kaela S Singleton, Rebecca Cross, Hannah Rudolph, Martha V Bruegge, Andrea Sweetman, Cecilia Garza, Eli Whisnant, Victor Faundez
The neurodevelopmental factor dysbindin is required for synapse function and GABA interneuron development. Dysbindin protein levels are reduced in the hippocampus of schizophrenia patients. Mouse dysbindin genetic defects and other mouse models of neurodevelopmental disorders share defective GABAergic neurotransmission and, in several instances, a loss of parvalbumin-positive interneuron phenotypes. This suggests that mechanisms downstream of dysbindin deficiency, such as those affecting GABA interneurons, could inform pathways contributing to or ameliorating diverse neurodevelopmental disorders...
2017: Frontiers in Genetics
https://www.readbyqxmd.com/read/28344488/direct-and-enhanced-delivery-of-nanoliposomes-of-anti-schizophrenic-agent-to-the-brain-through-nasal-route
#9
Pratik Upadhyay, Jatin Trivedi, Kilambi Pundarikakshudu, Navin Sheth
The problem of inadequate oral bioavailability of Quetiapine Fumarate, a lipophilic drug used for schizophrenia, due to hepatic metabolism and repulsion by brain barrier was attempted in this study. Combination of two approaches, viz. Quetiapine inclusion into the liposomal carrier for better diffusion and administration through nasal route to avoid hepatic metabolism and barrier elimination was applied. Thin film hydration followed by sonication method was employed in liposome preparation and the formulation was optimized using 3(2) full factorial design...
March 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/28344127/replicated-association-between-the-european-gwas-locus-rs10503253-at-csmd1-and-schizophrenia-in-asian-population
#10
Weiqing Liu, Fang Liu, Xiufeng Xu, Yan Bai
Schizophrenia is one of the most severe mental disorders with significant heritability. Recent genetic association studies including genome-wide association studies (GWAS) have identified multiple common variants conferring risk of schizophrenia. An intronic SNP within CSMD1, rs10503253, is one of the top risk SNPs for schizophrenia in Europeans discovered through large GWAS. However, whether rs10503253 is also a risk SNP for schizophrenia in other populations, such as Asians, is still unknown. To answer this question, we examined the association of rs10503253 with schizophrenia in a total of 7,514 schizophrenia patients, 9,058 healthy controls and 1,115 nuclear families originated from Asia using a meta-analytic approach...
March 23, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28344044/impairments-of-motor-function-among-children-with-a-familial-risk-of-schizophrenia-or-bipolar-disorder-at-7-years-old-in-denmark-an-observational-cohort-study
#11
Birgitte Klee Burton, Anne A E Thorup, Jens Richardt Jepsen, Gry Poulsen, Ditte Ellersgaard, Katrine S Spang, Camilla Jerlang Christiani, Nicoline Hemager, Ditte Gantriis, Aja Greve, Ole Mors, Merete Nordentoft, Kerstin Jessica Plessen
BACKGROUND: Owing to the genetic overlap between schizophrenia and bipolar disorder, we aimed to assess domain-specific motor aberrations and disorder specificity among 7-year-old children with a familial risk of schizophrenia or bipolar disorder by comparing children in familial risk groups with each other and with children not in these risk groups. METHODS: In the Danish High Risk and Resilience Study, we established a cohort of 7-year-old children with no, one, or two parents with schizophrenia or bipolar disorder in Denmark between Jan 1, 2013, and Jan 31, 2016...
March 23, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28343762/clozapine-and-incidence-of-myocarditis-and-sudden-death-long-term-australian-experience
#12
Arshad A Khan, Asma Ashraf, David Baker, Mohammed S Al-Omary, Lindsay Savage, Avedis Ekmejian, Rajinder Singh Harjit Singh, Stephen Brienesse, Tazeen Majeed, Tracy Gordon, Vincent Drinkwater, Nicholas J Collins
BACKGROUND: Clozapine is the cornerstone of therapy for refractory schizophrenia; however, the potential for cardiotoxicity is an important limitation in its use. In the current analysis we sought to evaluate the long term cardiac outcomes of clozapine therapy. METHODS: All-cause mortality, incidence of sudden death and time to myocarditis were assessed in a cohort of patients maintained on clozapine between January 2009 and December 2015. All patients had regular electrocardiograms, complete blood count, clozapine levels and echocardiography as part of a formal protocol...
March 6, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28343741/time-as-context-the-influence-of-hierarchical-patterning-on-sensory-inference
#13
Juanita Todd, Anne Petherbridge, Bronte Speirs, Alexander Provost, Bryan Paton
Time, or more specifically temporal structure, is a critical variable in understanding how the auditory system uses acoustic patterns to predict input, and to filter events based on their relevance. A key index of this filtering process is the auditory evoked potential component known as mismatch negativity or MMN. In this paper we review findings of smaller MMN in schizophrenia through the lens of time as an influential contextual variable. More specifically, we review studies that show how MMN to a locally rare pattern-deviation is modulated by the longer-term context in which it occurs...
March 23, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28343349/modernizing-quality-of-life-assessment-development-of-a-multidimensional-computerized-adaptive-questionnaire-for-patients-with-schizophrenia
#14
Pierre Michel, Karine Baumstarck, Christophe Lancon, Badih Ghattas, Anderson Loundou, Pascal Auquier, Laurent Boyer
OBJECTIVE: Quality of life (QoL) is still assessed using paper-based and fixed-length questionnaires, which is one reason why QoL measurements have not been routinely implemented in clinical practice. Providing new QoL measures that combine computer technology with modern measurement theory may enhance their clinical use. The aim of this study was to develop a QoL multidimensional computerized adaptive test (MCAT), the SQoL-MCAT, from the fixed-length SQoL questionnaire for patients with schizophrenia...
March 25, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28343167/the-unappreciated-roles-of-the-cholecystokinin-receptor-cck-1-in-brain-functioning
#15
Santiago Ballaz
The CCK(1) receptor is a G-protein-coupled receptor activated by the sulfated forms of cholecystokinin (CCK), a gastrin-like peptide released in the gastrointestinal tract and mammal brain. A substantial body of research supports the hypothesis that CCK(1)r stimulates gallbladder contraction and pancreatic secretion in the gut, as well as satiety in brain. However, this receptor may also fulfill relevant roles in behavior, thanks to its widespread distribution in the brain. The strategic location of CCK(1)r in mesolimbic structures and specific hypothalamic and brainstem nuclei lead to complex interactions with neurotransmitters like dopamine, serotonin, and glutamate, as well as hypothalamic hormones and neuropeptides...
March 25, 2017: Reviews in the Neurosciences
https://www.readbyqxmd.com/read/28343067/reading-problems-and-major-mental-disorders-co-occurrences-and-familial-overlaps-in-a-swedish-nationwide-cohort
#16
Martin Cederlöf, Barbara Maughan, Henrik Larsson, Brian M D'Onofrio, Robert Plomin
Reading problems often co-occur with ADHD and conduct disorder. However, the patterns of co-occurrence and familial overlap between reading problems and other psychiatric disorders have not been systematically explored. We conducted a register-based cohort study including 8719 individuals with reading problems and their siblings, along with matched comparison individuals. Conditional logistic regressions estimated risks for ADHD, autism, obsessive-compulsive disorder, anorexia nervosa, schizophrenia, bipolar disorder, depression, substance use disorder, and violent/non-violent criminality in individuals with reading problems and their siblings...
March 21, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28343053/self-reported-graphic-personal-and-social-performance-scale-srg-psp-for-measuring-functionality-in-patients-with-bipolar-disorder
#17
Ya Mei Bai, Cheng-Ta Li, Mu-Hong Chen, Yen Kuang Yang
OBJECTIVES: The self-reported graphic version of the Personal and Social Performance Scale (SRG-PSP) is the first graphic, self-reported rating scale that assesses functioning, and its reliability and validity have been documented in patients with schizophrenia. This study investigated the validity of SRG-PSP in patients with bipolar disorder (BD). METHODS: Patients with BD were recruited from psychiatric outpatient clinics, and assessed with the Young Mania Rating Scale (YMRS), the Montgomery-Åsberg Depression Rating Scale (MADRS), the Clinical Global Impression Scale (CGI)-Bipolar and CGI-Depression, the Positive and Negative Symptom Scale (PANSS), the Global assessment of function (GAF), and the PSP...
February 20, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28342945/cognitive-impairment-in-first-episode-drug-na%C3%A3-ve-patients-with-schizophrenia-relationships-with-serum-concentrations-of-brain-derived-neurotrophic-factor-and-glial-cell-line-derived-neurotrophic-factor
#18
Wenhuan Xiao, Fei Ye, Chunlai Liu, Xiaowei Tang, Jin Li, Hui Dong, Weiwei Sha, Xiaobin Zhang
OBJECTIVES: Evidence suggests that brain-derived neurotrophic factor (BDNF) and glial cell line -derived neurotrophic factor (GDNF) are important in the regulation of synaptic plasticity, which plays a key role in the cognitive processes in psychiatric disorders. Our work aimed at exploring the associations between serum BDNF and GDNF levels and cognitive functions in first-episode drug-naïve (FEDN) patients with schizophrenia. METHODS: The BDNF and GDNF levels of 58 FEDN patients and 55 age- and sex-matched healthy controls were measured and test subjects were examined using several neurocognitive tests including the verbal fluency test (VFT), the trail making test (TMT), the digit span test (DST), and the Stroop test...
March 22, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28342943/would-i-take-antipsychotics-if-i-had-psychotic-symptoms-examining-determinants-of-the-decision-to-take-antipsychotics
#19
Fabrice Berna, Anja S Göritz, Pierre-Michel Llorca, Pierre Vidailhet, Guillaume Fond, Steffen Moritz
Poor adherence to treatment in schizophrenia is mainly associated to patients-related factors. However, social negative representations of schizophrenia and its treatment may also contribute to patients' decision to take or not to take antipsychotics. A web-based study on 1807 participants was conducted during which participants imagined that they had a particular chronic illness based on clinical vignettes (mental illnesses: schizophrenia, depression; somatic illnesses: multiple sclerosis, rheumatoid arthritis)...
March 22, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28342897/dose-response-effect-of-acute-phencyclidine-on-functional-connectivity-and-dopamine-levels-and-their-association-with-schizophrenia-like-symptom-classes-in-rat
#20
Jaakko Paasonen, Raimo A Salo, Jouni Ihalainen, Juuso V Leikas, Katja Savolainen, Marko Lehtonen, Markus M Forsberg, Olli Gröhn
Current drug treatments for schizophrenia (SCZ) can alleviate positive symptoms, but have little effect on the negative symptoms and cognitive deficits that are difficult to translate into preclinical models for drug development. Therefore, we aimed to determine the dose-response effects of acute phencyclidine (PCP, 1.0-5.0 mg/kg) on rat brain connectivity and detect markers for different SCZ-like symptoms. Pharmacological functional magnetic resonance imaging (phMRI) and microdialysis were used to investigate PCP-induced effects on functional connectivity (FC) and dopamine levels, respectively...
March 22, 2017: Neuropharmacology
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