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https://www.readbyqxmd.com/read/29234980/low-dose-interleukin-2-as-a-modulator-of-treg-homeostasis-after-hsct-current-understanding-and-future-perspectives
#1
REVIEW
Ken-Ichi Matsuoka
CD4+CD25+Foxp3+ Treg is a functionally distinct subset of mature T cells with broad suppressive activity and has been shown to play an important role in the establishment of immune tolerance after HSCT. Altered cytokine environment in post-HSCT lymphopenia with a relative functional deficiency of IL-2 could hamper the reconstitution of Treg, leading to refractory GVHD. Based on the theory of low-dose IL-2 in which Treg can be selectively stimulated through the high-affinity IL-2 receptor, clinical studies have been conducted and demonstrated that low-dose IL-2 administration can restore Treg homeostasis and promote the expansion of this subset on the polymorphic processes of Treg reconstitution after HSCT...
December 12, 2017: International Journal of Hematology
https://www.readbyqxmd.com/read/29234390/astragaloside-iv-ameliorates-airway-inflammation-in-an-established-murine-model-of-asthma-by-inhibiting-the-mtorc1-signaling-pathway
#2
Hualiang Jin, Limin Wang, Bei Li, Cui Cai, Jian Ye, Junbo Xia, Shenglin Ma
Astragaloside IV (AS-IV), a main active constituent of Astragalus membranaceus, has been confirmed to have antiasthmatic effects. However, it remained unclear whether the beneficial effects of AS-IV on asthma were attributed to the mTOR inhibition; this issue was the focus of the present work. BALB/c mice were sensitized and challenged with ovalbumin followed with 3 weeks of rest/recovery and then reexposure to ovalbumin. AS-IV was administrated during the time of rest and reexposure. The characteristic features of allergic asthma, including airway hyperreactivity, histopathology, cytokines (IL-4, IL-5, IL-13, IL-17, and INF-γ), and CD4+CD25+Foxp3+Treg cells in bronchoalveolar lavage fluid (BALF), and downstream proteins of mTORC1/2 signaling were examined...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29229929/oestrogen-receptor-%C3%AE-binds-the-foxp3-promoter-and-modulates-regulatory-t-cell-function-in-human-cervical-cancer
#3
Sreenivas Adurthi, Mahesh M Kumar, H S Vinodkumar, Geetashree Mukherjee, H Krishnamurthy, K Kshitish Acharya, U D Bafna, Devi K Uma, B Abhishekh, Sudhir Krishna, A Parchure, Murali Alka, R S Jayshree
Oestrogen controls Foxp3 expression in regulatory T cells (Treg cells) via a mechanism thought to involve oestrogen receptor alpha (ERα), but the molecular basis and functional impact of ERα signalling in Treg cells remain unclear. We report that ERα ligand oestradiol (E2) is significantly increased in human cervical cancer (CxCa) tissues and tumour-infiltrating Treg cells (CD4+CD25hiCD127low), whereas blocking ERα with the antagonist ICI 182,780 abolishes FOXP3 expression and impairs the function of CxCa infiltrating Treg cells...
December 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29229400/tumor-necrosis-factor-producing-t-regulatory-cells-are-associated-with-severe-liver-injury-in-patients-with-acute-hepatitis-a
#4
Yoon Seok Choi, Min Kyung Jung, Jeewon Lee, Seong Jin Choi, Sung Hoon Choi, Hyun Woong Lee, Jong-Joo Lee, Hyung Joon Kim, Sang Hoon Ahn, Dong Hyeon Lee, Won Kim, Su-Hyung Park, Jun R Huh, Hyoung-Pyo Kim, Jun Yong Park, Eui-Cheol Shin
BACKGROUND AND AIMS: CD4+CD25+Foxp3+ T-regulatory (Treg) cells control immune responses and maintain immune homeostasis. However, under inflammatory conditions, Treg cells produce cytokines that promote inflammation. We investigated production of tumor necrosis factor (TNF) by Treg cells in patients with acute hepatitis A (AHA), and examined the characteristics of these cells and association with clinical factors. METHODS: We analyzed blood samples collected from 63 patients with AHA at the time of hospitalization (and some at later time points) and 19 healthy donors in South Korea...
December 8, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29229149/transfusion-of-ethylene-carbodiimide-fixed-donor-splenocytes-prolongs-survival-of-vascularized-skin-allografts
#5
Jianke Ding, Shiqiang Liu, Dongliang Zhang, Yajuan Song, Xianjie Ma, Chenggang Yi, Baoqiang Song, Bo Xiao, Yingjun Su, Shuzhong Guo
BACKGROUND: Allograft rejection is a major obstacle to the widespread clinical application of vascularized composite allotransplantation. Recent studies revealed a noncytoreductive strategy to protect allografts by the transfusion of ethylene carbodiimide-fixed donor splenocytes (ECDI-SPs). To determine whether this approach offers advantages in protecting skin allografts, we examined the immunological protection of infusing ECDI-SPs with a 30-d administration of rapamycin on the skin allografts of mice...
January 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29228993/programmed-cell-death-5-transgenic-mice-attenuates-adjuvant-induced-arthritis-by-2-modifying-the-t-lymphocytes-balance
#6
Feng Yuan, Junfeng Wang, Keshi Zhang, Zhao Li, Zhenpeng Guan
BACKGROUND: Programmed cell death 5 (PDCD5) is an apoptosis-related gene cloned from TF-1 cells whose primary biological functions are to promote apoptosis and immune regulation. The effects and mechanisms exerted by key mediators of arthritic inflammation remain unclear in PDCD5 transgenic (PDCD5 tg) mice. RESULTS: In the current study, PDCD5 tg mice inhibited the progression of adjuvant-induced arthritis, specifically decreasing clinical signs and histological damage, compared with arthritis control mice...
December 11, 2017: Biological Research
https://www.readbyqxmd.com/read/29226383/bifidobacterium-alleviated-experimentally-induced-colitis-by-upregulating-in-doleamine-2-3-dioxygenase-expression
#7
Li Zhao, Yangzhen Suolang, Dandan Zhou, Yu Tang, Yan Zhang
The goal of this study was explore the role of indoleamine 2, 3-dioxygenase (IDO) in the therapeutic effect of probiotics on inflammatory bowel disease (IBD). Trinitro-benzene sulfonic acid (TNBS) was used to induce colitis in mice, and 1-methyltryptophan (1-MT) was used to block the expression of IDO. Clinical manifes-tations, macroscopic and microscopic colonic alterations were assessed using the dis-ease activity index (DAI), Wallace-Keenan, and Curtner scoring systems, respectively. The expression of colonic IDO was detected by western blot...
December 11, 2017: Microbiology and Immunology
https://www.readbyqxmd.com/read/29225597/tregs-where-we-are-and-what-comes-next
#8
REVIEW
Hai Zhao, Xuelian Liao, Yan Kang
Regulatory T cells are usually recognized as a specialized subset of CD4+ T cells functioning in establishment and maintenance of immune tolerance. Meanwhile, there is emerging evidence that regulatory T cells (Tregs) are also present in various non-lymphoid tissues, and that they have unique phenotypes credited with activities distinct from regulatory function. Their development and function have been described in plenty of manuscripts in the past two decades. However, with the deepening of research in recent years, emerging evidence revealed some novel mechanisms about how Tregs exert their activities...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29225189/luteolin-attenuates-airway-inflammation-by-inducing-the-transition-of-cd4-cd25-to-cd4-cd25-regulatory-t-cells
#9
Seung-Hyung Kim, Evelyn Saba, Bok-Kyu Kim, Won-Kyung Yang, Yang-Chun Park, Han Jae Shin, Chang Kyun Han, Young Cheol Lee, Man Hee Rhee
Regulatory T cells (Th2) play an important role in autoimmunity and have been shown to exert anti-inflammatory effects in allergic asthma. Mouse model of airway inflammation was used to examine the suppressive activity of luteolin-induced CD4+CD25+ regulatory T cells (Tregs) in vivo. In this study, BALB/c mice were sensitized with ovalbumin antigen (OVA) by aerosol challenge. Then, various biological processes were examined, including airway eosinophilia; mucus hypersecretion; elevation of OVA-specific IgE, expression of Th2 cytokines and chemokine levels; expression of eotaxin 2 and CCR3; and airway hyper responsiveness (AHR)...
December 7, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29223407/stat3-mediated-epigenetic-silencing-of-foxp3-in-lada-t-cells-is-regulated-through-hdac5-and-dnmt1
#10
Can Hou, Yanjun Zhong, Zhen Wang, Zhao Ming, Gan Huang, Lin Ouyang, Yijun Li, Qianjin Lu, Zhiguang Zhou
In LADA patients, Tregs are reduced and FOXP3 is downregulated in CD4+ T cells, but the etiology remains unclear. Our study included in 20 LADA patients and 20 healthy control patients. qRT-PCR results showed that STAT3, HDAC3, HDAC5, SIRT1, DNMT1 and DNMT3b mRNAs were significantly upregulated in LADA CD4+ T cells than controls, while FOXP3 mRNA significantly decreased. p-STAT3, STAT3, DNMT1 and DNMT3b expressions were increased demonstrated by western blot. ChIP-PCR suggested that p-STAT3 binds to the Foxp3 promoter, meanwhile, histone H3 acetylation at K9 and K14 of FOXP3 promoter were significantly lower than controls...
December 6, 2017: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/29223294/glucocorticoid-hormone-treatment-enhances-the-cytokine-production-of-regulatory-t-cells-by-upregulation-of-foxp3-expression
#11
Emese Ugor, Lilla Prenek, Ramóna Pap, Gergely Berta, Dávid Ernszt, József Najbauer, Péter Németh, Ferenc Boldizsár, Tímea Berki
OBJECTIVE: Despite the fact that glucocorticoids (GC) are important therapeutic tools, their effects on regulatory T cells (Treg) are not well defined. The aim of our work was to investigate how GCs influence in vivo the thymic (tTreg) and peripheral Treg (pTreg) differentiation, survival and cytokine production. METHODS: Tregs were detected with flow cytometry in lymphatic organs of 4-6 weeks old BALB/c mice after repeated (2-4days), high-dose in vivo GC treatment using CD4/CD25 cell surface and Foxp3/IL-10/TGFβ/glucocorticoid receptor (GR) intracellular staining...
October 6, 2017: Immunobiology
https://www.readbyqxmd.com/read/29218244/exosomal-tgf-%C3%AE-1-is-correlated-with-lymphatic-metastasis-of-gastric-cancers
#12
Er-Yen Yen, Shi-Chuen Miaw, Jhang-Sian Yu, I-Rue Lai
Exosomes are nano-vesicles transporting bioactive material between cells. This study explored the prognostic association of exosomal TGF-β1 with lymph node (LN) metastasis of gastric cancer (GC). TGF-β1 expressions in the exosomes isolated from the gastroepiploic veins of 61 GC patients analyzed by ELISA. The regulatory T (Treg) cells in celiac LNs of gastric cancer analyzed by immunohistochemistry. Exosomal TGF-β1 expression and the ratio of Treg cells in draining LNs were both significantly associated with pathological stages and LN metastasis of gastric cancer...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/29218089/the-role-of-sildenafil-in-the-development-of-transplant-arteriosclerosis-in-rat-aortic-grafts
#13
Shuai Luo, Mei Yang, Hao Jin, Zi-Qiang Xu, Yi-Fu Li, Peng Xia, Yi-Rrong Yang, Bi-Cheng Chen, Yan Zhang
Chronic rejection (CR), which is characterized histologically by progressive graft arteriosclerosis, remains a significant barrier to the long-term survival of a graft. Sildenafil has been shown to protect vascular endothelial cells. In this study, we found that sildenafil significantly reduces the thickness of transplant vascular intima in a rat aortic transplant model. Moreover, sildenafil dramatically decreased the expression of transforming growth factor-β1 (TGF-β1), vascular endothelial growth factor (VEGF), and α-smooth muscle actin (α-SMA) in the grafted aortas and increased the concentrations of cyclic guanosine monophosphate (cGMP) and endothelial nitric oxide synthase (eNOS) in serum...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/29216911/dynamic-expression-of-cytokine-and-transcription-factor-genes-during-experimental-fasciola-gigantica-infection-in-buffaloes
#14
Wei Shi, Zhi-Yong Wei, Hany M Elsheikha, Fu-Kai Zhang, Zhao-An Sheng, Ke-Jing Lu, Dong-Ying Wang, Wei-Yi Huang, Xing-Quan Zhu
BACKGROUND: Determining the mechanisms involved in the immune-pathogenesis of the tropical liver fluke, Fasciola gigantica, is crucial to the development of any effective therapeutic intervention. Here, we examined the differential gene expression of cytokines and transcription factors in the liver of F. gigantica-infected buffaloes, over the course of infection. METHODS: Water buffaloes (swamp type) were infected orally with 500 F. gigantica encysted metacercariae...
December 8, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/29213081/pak2-is-essential-for-the-function-of-foxp3-regulatory-t-cells-through-maintaining-a-suppressive-treg-phenotype
#15
Kyle L O'Hagan, Stephen D Miller, Hyewon Phee
Foxp3, a key transcription factor that drives lineage differentiation of regulatory T cells (Tregs), was thought to imprint a unique and irreversible genetic signature within Tregs. Recent evidence, however, suggests that loss or attenuation of Foxp3 expression can cause Tregs to de-differentiate into effector T cells capable of producing proinflammatory cytokines. Herein, we report that the signaling kinase, p21-activated kinase 2 (Pak2), is essential for maintaining Treg stability and suppressive function...
December 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29212449/maternal-variant-in-the-upstream-of-foxp3-gene-on-the-x-chromosome-is-associated-with-recurrent-infertility-in-japanese-black-cattle
#16
Taichi Arishima, Shinji Sasaki, Tomohiro Isobe, Yoshihisa Ikebata, Shinichi Shimbara, Shogo Ikeda, Keisuke Kawashima, Yutaka Suzuki, Manabu Watanabe, Sumio Sugano, Kazunori Mizoshita, Yoshikazu Sugimoto
BACKGROUND: Repeat breeding, which is defined as cattle failure to conceive after three or more inseminations in the absence of clinical abnormalities, is a substantial problem in cattle breeding. To identify maternal genetic variants of repeat breeding in Japanese Black cattle, we selected 29 repeat-breeding heifers that failed to conceive following embryo transfer (ET) and conducted a genome-wide association study (GWAS) using the traits. RESULTS: We found that a single-nucleotide polymorphism (SNP; g...
December 6, 2017: BMC Genetics
https://www.readbyqxmd.com/read/29212384/articular-and-subcutaneous-adipose-tissues-of-rheumatoid-arthritis-patients-represent-equal-sources-of-immunoregulatory-mesenchymal-stem-cells
#17
Urszula Skalska, Ewa Kuca-Warnawin, Anna Kornatka, Iwona Janicka, Urszula Musiałowicz, Tomasz Burakowski, Ewa Kontny
Adipose-derived mesenchymal stem cells (ASCs) have immunoregulatory properties, but their activity is dependent on signals provided by the local microenvironment. It is likely that highly inflammatory milieu of rheumatoid joint affects ASCs activity. To test this hypothesis, the function of rheumatoid ASCs derived from articular adipose tissue (AT-ASCs) and ASCs derived from subcutaneous adipose tissue (Sc-ASCs) has been analysed. Articular adipose tissue (infrapatellar fat pad) and subcutaneous adipose tissue (from the site of skin closure with sutures) were obtained from rheumatoid arthritis (RA) patients undergoing total knee joint replacement surgery...
December 6, 2017: Autoimmunity
https://www.readbyqxmd.com/read/29210727/regulatory-t-cells-from-the-bench-to-the-clinic-and-back
#18
Basmah S Al Dulaijan, Amr Mansouri, Jordan Karnyski, Jamil Azzi
PURPOSE OF REVIEW: The main objective of this review is to briefly highlight how we gradually came to understand regulatory T cells (Tregs) and forkhead box p3 (FoxP3) biology, including their function and regulation. We will also discuss how this knowledge is being translated into the clinical setting and the significant challenges that need to be overcome. RECENT FINDINGS: CD4FoxP3 Tregs are key players in immune regulation. Their deficiency and dysfunction have been implicated in the pathogenesis of many autoimmune diseases...
November 27, 2017: Current Opinion in Organ Transplantation
https://www.readbyqxmd.com/read/29209232/the-clinicopathological-and-prognostic-implications-of-foxp3-regulatory-t-cells-in-patients-with-colorectal-cancer-a-meta-analysis
#19
Peipei Xu, Wei Fan, Zheng Zhang, June Wang, Ping Wang, Yirong Li, Mingxia Yu
Background and Objective: Forkhead box P3 (FoxP3) is known as the specific marker for regulatory T lymphocytes (Tregs), which are responsible for self-tolerance and disturb the antitumor immunity. However, the prognostic implication of tumor-infiltrating FoxP3+ Tregs in patients with colorectal cancer (CRC) still remains controversial. The aim of this present study was to investigate the prognostic role of FoxP3+ Tregs in CRC through meta-analysis. Methods: PubMed, Embase and Web of Science were searched for relevant articles up to December 12, 2016...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29207606/combination-therapy-with-an-ox40l-fusion-protein-and-a-vaccine-targeting-the-transcription-factor-twist-inhibits-metastasis-in-a-murine-model-of-breast-cancer
#20
Anthony S Malamas, Scott A Hammond, Jeffrey Schlom, James W Hodge
OX40 is a costimulatory receptor that potentiates proliferation, survival, memory formation, and effector function of CD4+ and CD8+ T-cells, while overcoming the suppressive activity of regulatory T-cells (Tregs). Here, we explored the combination of an OX40L fusion protein (OX40L-FP) with a poxvirus-based cancer vaccine (MVA-Twist-TRICOM) to inhibit tumor metastasis in the 4T1 murine breast cancer model. Contrary to the single agent treatments, the combination therapy significantly decreased the number of metastatic colonies per lung and prolonged survival...
October 31, 2017: Oncotarget
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