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https://www.readbyqxmd.com/read/29932060/study-of-the-association-of-forkhead-box-p3-foxp3-gene-polymorphisms-with-unexplained-recurrent-spontaneous-abortions-in-indian-population
#1
Shivani Mishra, Anukool Srivastava, Kausik Mandal, Shubha R Phadke
Recurrent spontaneous abortions (RSA) is defined as three or more consecutive pregnancy losses before 20 weeks of gestation. Various causes of RSA have been identified, still 50% cases remain unexplained after evaluation. One of the causes of unexplained recurrent spontaneous abortions (URSA) is supposed to be the disruption of immunological tolerance at foeta-maternal interface. Regulatory T cells (Tregs) are responsible for the development of immune-tolerant environment at foetal-maternal interface and supports pregnancy...
June 2018: Journal of Genetics
https://www.readbyqxmd.com/read/29929402/combined-immunization-against-tgf-%C3%AE-1-enhances-hpv16-e7-specific-vaccine-elicited-antitumour-immunity-in-mice-with-grafted-tc-1-tumours
#2
Xiaojie Chu, Yang Li, Weiwei Huang, Xuejun Feng, Pengyan Sun, Yufeng Yao, Xu Yang, Wenjia Sun, Hongmei Bai, Cunbao Liu, Yanbing Ma
Therapeutic vaccine appears to be a potential approach for the treatment of human papillomavirus (HPV)-associated tumours, but its efficacy can be dampened by immunosuppressive factors such as transforming growth factor (TGF)-β1. We sought to investigate whether active immunity against TGF-β1 enhances the anti-tumour immunity elicited by an HPV16 E7-specific vaccine that we developed previously. In this study, virus-like particles of hepatitis B virus core antigen were used as vaccine carriers to deliver either TGF-β1 B cell epitopes or E7 cytotoxic T-lymphocyte epitope...
June 22, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29928442/a-novel-potential-effective-strategy-for-enhancing-the-antitumor-immune-response-in-breast-cancer-patients-using-a-viable-cancer-cell-dendritic-cell-based-vaccine
#3
Mona S Abdellateif, Sabry M Shaarawy, Eman Z Kandeel, Ahmed H El-Habashy, Mohamed L Salem, Motawa E El-Houseini
Dendritic cells (DCs) have been used in a number of clinical trials for cancer immunotherapy; however, they have achieved limited success in solid tumors. Consequently the aim of the present study was to identify a novel potential immunotherapeutic target for breast cancer patients through in vitro optimization of a viable DC-based vaccine. Immature DCs were primed by viable MCF-7 breast cancer cells and the activity and maturation of DCs were assessed through measuring CD83, CD86 and major histocompatibility complex (MHC)-II expression, in addition to different T cell subpopulations, namely CD4+ T cells, CD8+ T cells, and CD4+ CD25+ forkhead box protein 3 (Foxp3)+ regulatory T cells (Tregs), by flow cytometric analysis...
July 2018: Oncology Letters
https://www.readbyqxmd.com/read/29928435/matrix-metalloproteinase-12-expression-is-associated-with-tumor-foxp3-regulatory-t-cell-infiltration-and-poor-prognosis-in-hepatocellular-carcinoma
#4
Min-Ke He, Yong Le, Yong-Fa Zhang, Han-Yue Ouyang, Pei-En Jian, Zi-Shan Yu, Li-Juan Wang, Ming Shi
Hepatocellular carcinoma (HCC) is among the most fatal types of cancer worldwide due to its high rates of recurrence and metastasis. The molecular processes involved in HCC progression require further investigation to identify biomarkers for use in diagnosis and treatment. In the present study, the significance and prognostic value of matrix metallopeptidase 12 (MMP12) expression in human HCC was investigated. MMP12 mRNA expression was investigated using reverse transcription-quantitative polymerase chain reaction analysis of 42 pairs of tumor and non-tumor liver tissues obtained from patients with HCC following surgical treatment...
July 2018: Oncology Letters
https://www.readbyqxmd.com/read/29923026/inhibition-of-the-adenosine-a2a-receptor-modulates-expression-of-t-cell-coinhibitory-receptors-and-improves-effector-function-for-enhanced-checkpoint-blockade-and-act-in-murine-cancer-models
#5
Robert D Leone, Im-Meng Sun, Min-Hee Oh, Im-Hong Sun, Jiayu Wen, Judson Englert, Jonathan D Powell
Adenosine signaling via the A2a receptor (A2aR) is emerging as an important checkpoint of immune responses. The presence of adenosine in the inflammatory milieu or generated by the CD39/CD73 axis on tissues or T regulatory cells serves to regulate immune responses. By nature of the specialized metabolism of cancer cells, adenosine levels are increased in the tumor microenvironment and contribute to tumor immune evasion. To this end, small molecule inhibitors of the A2aR are being pursued clinically to enhance immunotherapy...
June 19, 2018: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/29915563/immunological-profile-and-predisposition-to-autoimmunity-in-girls-with-turner-syndrome
#6
Aneta Monika Gawlik, Elzbieta Berdej-Szczot, Dorota Blat, Renata Klekotka, Tomasz Gawlik, Ewa Blaszczyk, Magdalena Hankus, Ewa Malecka-Tendera
Objective: The risk of autoimmune diseases (AD) in patients with Turner Syndrome (TS) is twice higher than in the general female population and four times higher than in the male population. The causes of the increased incidence of AD in TS are still under discussion. We hypothesized the presence of a specific humoral, cellular, and regulatory T cell (Treg) immunity profile which predisposes to AD, disorders of immunity, and disorders of immune regulation. Methods: The study encompassed 37 girls with TS and with no signs of infection...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29914685/glucocorticosteroids-administration-is-associated-with-increased-regulatory-t-cells-in-equine-asthmatic-lungs
#7
Roxane Boivin, Amandine Vargas, Patricia Cano, Jean-Pierre Lavoie
Recurrent inflammation in severe equine asthma causes a remodeling of the airways leading to incompletely reversible airway obstruction. Despite the improvement of clinical signs and lung function with glucocorticoids (GC), inflammation, translated by an increased percentage of neutrophils, persists in the airways. Regulatory T cells (Treg) have been shown to have anti-inflammatory properties and play an important role in balancing the immune response by suppressing effector lymphocyte activity. However, interactions between Treg, neutrophils and glucocorticosteroids in vivo are unclear, particularly in asthma...
July 2018: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/29910815/-toxoplasma-chinese-1-strain-of-wh3%C3%AE-rop16-i-iii-gra15-ii-genetic-background-contributes-to-abnormal-pregnant-outcomes-in-murine-model
#8
Cong Wang, Weisheng Cheng, Qian Yu, Tian Xing, Shoubin Chen, Lei Liu, Li Yu, Jian Du, Qingli Luo, Jilong Shen, Yuanhong Xu
Toxoplasma gondii infection evokes a strong Th1-type response with interleukin (IL)-12 and interferon (IFN)-γ secretion. Recent studies suggest that the infection of pregnant mice with T. gondii may lead to adverse pregnancy results caused by subversion of physiological immune tolerance at maternofetal interface rather than direct invasion of the parasite. Genotype-associated dense granule protein GRA15II tends to induce classically activated macrophage (M1) differentiation and subsequently activating NK, Th1, and Th17 cells whereas rhoptry protein ROP16I/III drives macrophages to alternatively activated macrophage (M2) polarization and elicits Th2 immune response...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29910670/icos-signal-facilitates-foxp3-transcription-to-favor-suppressive-function-of-regulatory-t-cells
#9
Qianmei Chen, Lijun Mo, Xiangsheng Cai, Lili Wei, Zhengneng Xie, Hongwei Li, Jinlong Li, Zhiming Hu
Inducible costimulator (ICOS) plays an important role in the suppressive immunity mediated by regulatory T cells (Tregs), but the molecular regulation mechanism is not well known. Here we performed a study to explore the possible mechanism by which ICOS regulates the suppressive functions and survival of Tregs. This study showed that both the ICOS and CD28 signal could promote the survival of Tregs. However, ICOS but not CD28 improved the suppressive function of Tregs. Mechanistic studies demonstrated that ICOS could induce the transcription activity of Foxp3, by facilitating the nuclear factor of activated T cells (NFAT): Foxp3 over NFAT: activator protein 1 (AP-1)...
2018: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29909346/kuijieling-regulates-the-differentiation-of-treg-and-th17-cells-to-ameliorate-experimental-colitis-in-rats
#10
Yu Long, Sixin Li, Jingchun Qin, Liwei Xie, Liping Gan, Fengming Jie, Yanli Wu, Yanwu Li, Qun Du
BACKGROUND: Regulatory T (Treg) cells and T helper 17 (Th17) cells play crucial roles in ulcerative colitis (UC). Kuijieling (KJL) is an effective Chinese medicine formula for treating UC in clinic. Kuijieling has shown remedy effect on the imbalance between Treg and Th17 cells. This study aimed to further reveal the exact underlying mechanism of how Kuijieling regulates the differentiation of Treg and Th17 cells in the treatment of UC. METHODS: Colitis was induced by trinitrobenzene sulfonic acid in rats and treated by KJL...
June 14, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29909233/phenotype-analyses-of-il-10-producing-foxp3-cd4-t-cells-increased-by-subcutaneous-immunotherapy-in-allergic-airway-inflammation
#11
Masaya Matsuda, Yuki Morie, Hirotaka Oze, Kana Doi, Tatsuya Tsutsumi, Junpei Hamaguchi, Miki Inaba, Takeshi Nabe
INTRODUCTION: The mechanisms of allergen immunotherapy are not fully elucidated. Here, we sought to develop a murine model to demonstrate the effectiveness of subcutaneous immunotherapy (SCIT) for allergic responses. As excessive antigen dosages may induce immune tolerance in sensitized mice, the effects of SCIT were assessed by varying the antigen dosage. The mechanisms of SCIT were analyzed by focusing on the induction of Foxp3+ Treg cells and IL-10-producing Foxp3- CD4+ T cells, as well as on the phenotype of the latter cells...
June 14, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29908119/cd4-foxp3-regulatory-t-cell-mediated-immunomodulation-by-anti-depressants-inhibiting-acid-sphingomyelinase
#12
Jürgen Schneider-Schaulies, Niklas Beyersdorf
Acid sphingomyelinase (ASM) is the rate-limiting enzyme cleaving sphingomyelin into ceramide and phosphorylcholin. CD4+ Foxp3+ regulatory T (Treg) cells depend on CD28 signaling for their survival and function, a receptor that activates the ASM. Both, basal and CD28-induced ASM activities are higher in Treg cells than in conventional CD4+ T (Tconv) cells. In ASM-deficient (Smpd1-/-) as compared to wt mice, membranes of T cells contain 7-10-fold more sphingomyelin and 2-3-fold more ceramide, and are in a state of higher order than membranes of T cells from wt mice, which may facilitate their activation...
June 1, 2018: Biological Chemistry
https://www.readbyqxmd.com/read/29907586/yap-is-essential-for-treg-mediated-suppression-of-anti-tumor-immunity
#13
Xuhao Ni, Jinhui Tao, Joseph Barbi, Qian Chen, Benjamin V Park, Zhiguang Li, Nailing Zhang, Andriana Lebid, Anjali Ramaswamy, Ping Wei, Ying Zheng, Xuehong Zhang, Xingmei Wu, Paolo D A Vignali, Cuiping Yang, Huabin Li, Drew Pardoll, Ling Lu, Duojia Pan, Fan Pan
Regulatory T cells (Tregs) are critical for maintaining self-tolerance and immune homeostasis, but their suppressive function can impede effective anti-tumor immune responses. Foxp3 is a transcription factor expressed in Tregs that is required for their function. However, the pathways and microenvironmental cues governing Foxp3 expression and Treg function are not completely understood. Herein, we report that Yes-associated protein (YAP), a co-activator of the Hippo pathway, is highly expressed in Tregs and bolsters Foxp3 expression and Treg function in vitro and in vivo...
June 15, 2018: Cancer Discovery
https://www.readbyqxmd.com/read/29907361/mesenchymal-stem-cell-expression-of-interleukin-35-protects-against-ulcerative-colitis-by-suppressing-mucosal-immune-responses
#14
Yongjia Yan, Na Zhao, Xianghui He, Hao Guo, Zhixiang Zhang, Tong Liu
BACKGROUND: Interleukin-35 (IL-35) has recently been identified as an immunosuppressive cytokine that has been used as a potential therapy for chronic inflammatory and autoimmune diseases. However, there remains a paucity of data regarding its potential benefits after integration into mesenchymal stem cells (MSCs). METHODS: We used a dextran sulfate sodium (DSS)-induced colitis mice model and treated them with IL-35-MSCs, MSCs or saline. The body weight was recorded daily and inflammatory processes were determined...
June 12, 2018: Cytotherapy
https://www.readbyqxmd.com/read/29905955/co-expression-of-lag3-and-tim3-identifies-a-potent-treg-population-that-suppresses-macrophage-functions-in-colorectal-cancer-patients
#15
Qiang Ma, Junning Liu, Guoliang Wu, Mujian Teng, Shaoxuan Wang, Meng Cui, Yuantao Li
Regulatory T (Treg) cells are critical suppressors of inflammation and are thought to exert mainly deleterious effects in cancers. In colorectal cancer (CRC), Foxp3+  Treg accumulation in the tumor was associated with poor prognosis. Hence, we examined the circulating Treg cells in CRC patients. Compared to controls, CRC patients presented mild upregulations in CD4+ CD25+/hi T cells and in the more canonical CD4+ CD25+/hi Foxp3+ Treg cells in peripheral blood mononuclear cells. Both of these Treg populations could be roughly divided into LAG3- TIM3- and LAG3+ TIM3+ subsets...
June 15, 2018: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29904967/downregulation-of-ilt4-dendritic-cells-in-recurrent-miscarriage-and-recurrent-implantation-failure
#16
Su Liu, Hongxia Wei, Yuye Li, Chunyu Huang, Ruochun Lian, Jian Xu, Lanna Chen, Yong Zeng
PROBLEM: The role of ILT4+ DCs in healthy fertile controls and patients with recurrent miscarriages (RM) and recurrent implantation failure (RIF) is unclear. METHOD OF STUDY: We studied the expression of ILT4 from peripheral blood and endometrial samples from healthy controls and patients with RM and RIF by flow cytometry and immunohistochemistry analysis. Endometrial Foxp3 expression was also investigated using immunohistochemistry. RESULTS: In peripheral blood, there was a significant increase in the percentage of ILT4+ DCs in healthy fertile controls compared with patients with RM and RIF...
June 14, 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29904934/common-gamma-chain-cytokines-promote-regulatory-t-cell-development-and-survival-at-the-cd4-cd8-stage-in-the-human-thymus
#17
Reetta Vanhanen, Anni Tuulasvaara, Joonatan Mattila, Tommi Pätilä, T Petteri Arstila
Thymic commitment of human FOXP3+ regulatory T cells begins at the double positive (DP) CD4+ CD8+ stage. In the current study we show that interleukin-2 promotes the development of FOXP3+ thymocytes and enhances their survival at the DP phase. IL-2 increases the frequency of FOXP3+ cells and promotes the Treg phenotype after TCR-mediated positive selection at the most mature DP stage. However, it has no effect on FOXP3+ cells at the earlier maturation steps before positive selection. DP FOXP3+ are highly susceptible to cell death but IL-2 promotes their survival...
June 15, 2018: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/29901858/hypoxia-inducible-factor-1%C3%AE-plays-a-predominantly-negative-role-in-regulatory-t-cell-functions
#18
REVIEW
Tzu-Sheng Hsu, Ming-Zong Lai
Hypoxia-inducible factor 1α (HIF-1α) regulates cellular responses to hypoxia. However, conflicting roles for HIF-1α in the functions of regulatory T cells (Tregs) have been reported. In this review, we summarize observations on the requirement for HIF-1α for FOXP3 expression and Tregs development, as well as for HIF-1α-mediated downregulation of FOXP3 and Tregs destabilization. We also examine the association of HIF-1α with Tregs under pathogenic conditions. Based on these findings, we suggest that HIF-1α mainly plays a detrimental role in the function and stability of Tregs and that HIF-1α is disposable for the development and suppressive function of Tregs...
June 14, 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29901207/aberrant-expression-of-foxp3-in-a-human-t-cell-line-possessing-regulatory-t-cell%C3%A2-like-function-and-exposed-continuously-to-asbestos-fibers
#19
Megumi Maeda, Hidenori Matsuzaki, Shoko Yamamoto, Suni Lee, Naoko Kumagai-Takei, Kei Yoshitome, Yu Min, Nagisa Sada, Yasumitsu Nishimura, Takemi Otsuki
Prompted by the known carcinogenic activity of asbestos, our investigations revealed that asbestos causes a reduction in antitumor immunity. One mechanism involves the enhancement of regulatory T (Treg) cell function and volume assayed using MT‑2 original cells (Org), an HTLV‑1 immortalized human T cell line which possesses Treg‑like function. Continuous and relatively low‑dose exposure of MT‑2 to asbestos fibers yielded sublines resistant to asbestos‑induced apoptosis and enhanced Treg function via cell‑cell contact mechanisms and increased the production of soluble factors such as interleukin (IL)‑10 and transforming growth factor (TGF)‑β...
June 7, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29900065/the-immune-checkpoint-protein-pd-l1-induces-and-maintains-regulatory-t-cells-in-glioblastoma
#20
Joseph DiDomenico, Jonathan B Lamano, Daniel Oyon, Yuping Li, Dorina Veliceasa, Gurvinder Kaur, Leonel Ampie, Winward Choy, Jason B Lamano, Orin Bloch
Glioblastoma (GBM) promotes immunosuppression through upregulation of PD-L1 and regulatory T cell (Treg) expansion, but the association of these suppressive factors has not been well elucidated. Here, we investigate a role of PD-L1 in expanding Tregs and the value of targeting the PD-1 receptor to inhibit Treg expansion. Quantitative RNA sequencing data from The Cancer Genome Atlas were evaluated for an association between CD274 and FOXP3 transcript expressions and impact of FOXP3 on clinical outcomes. Peripheral leukocytes from patients with newly diagnosed GBM were profiled for PD-L1+ myeloid expressions and Treg abundance...
2018: Oncoimmunology
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