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https://www.readbyqxmd.com/read/29331885/autonomously-hyperfunctioning-cystic-nodule-harbouring-thyroid-carcinoma-case-report-and-literature-review
#1
Maria João Lima, Virgínia Soares, Pedro Koch, Artur Silva, António Taveira-Gomes
INTRODUCTION: Hyperthyroidism is rarely associated with malignancy, but it cannot rule out thyroid cancer. Although there is published data describing this coexistence, thyroid carcinomas inside autonomously functioning nodules are uncommon. PRESENTATION OF CASE: A 49-year-old woman presented with a cervical mass, unexplained weight loss and anxiousness, sweating and insomnia. On physical examination, she had a palpable left thyroid nodule. Thyroid function tests showed suppressed TSH (<0,1 uUI/mL), thyroxine 1,44 ng/dL (normal range 0,70-1,48) and triiodothyronine 4,33 pg/mL (normal range 1,71-3,71)...
January 8, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29330579/-initially-undetected-de-novo-psoriasis-triggered-by-nivolumab-for-metastatic-base-of-the-tongue-carcinoma
#2
S Troyanova-Slavkova, L Eickenscheidt, K Dumann, L Kowalzick
Nivolumab is a monoclonal antibody that binds to the PD-1 receptor on T cells and inhibits the interaction with the PD-L1 and PD-L2 ligands on cancer cells. Thus, nivolumab has immunostimulatory properties. The known side effects of this therapy include fatigue, skin rash, dysfunction of the thyroid gland and colitis, which are explained by the immunoregulatory mechanisms of the drug. Here we report on the case of a 58-year-old man with metastatic base of tongue carcinoma who developed de novo psoriasis triggered by nivolumab...
January 12, 2018: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/29329789/lateral-lymph-node-metastasis-in-papillary-thyroid-carcinoma-a-systematic-review-and-meta-analysis-for-prevalence-risk-factors-and-location
#3
REVIEW
Yoon Kyoung So, Min-Ji Kim, Seonwoo Kim, Young-Ik Son
BACKGROUND: Lymph node metastasis (LNM) is frequent in papillary thyroid carcinoma (PTC) and is associated with a poor prognosis. Unlike central LNM (CLNM), there are few studies focusing on LLNM. We aimed to investigate the prevalence and the risk factors for LLNM, with its most prevalent sites. METHODS: We performed a comprehensive literature search using the PubMed and EMBASE databases for relevant studies published prior to November 2016 that examined the risk factors for LLNM...
January 9, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29328463/construction-and-investigation-of-lncrna-associated-cerna-regulatory-network-in-papillary-thyroid-cancer
#4
Yangjing Zhao, Hui Wang, Chengjiang Wu, Meina Yan, Haojie Wu, Jingzhe Wang, Xinxin Yang, Qixiang Shao
Increasing evidence has experimentally proved the competitive endogenous RNA (ceRNA) hypothesis that long non-coding RNA (lncRNA) can affect the expression of RNA targets by competitively combining microRNA (miRNA) via miRNA response elements. However, an extensive ceRNA network of thyroid carcinoma in a large cohort has not been evaluated. We analyzed the RNAseq and miRNAseq data of 348 cases of primary papillary thyroid cancer (PTC) patients with clinical information downloaded from The Cancer Genome Atlas (TCGA) project to search for potential biomarkers or therapeutic targets...
January 10, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29325506/clinical-impact-of-detectable-antithyroglobulin-antibodies-below-the-reference-limit-borderline-in-patients-with-papillary-thyroid-carcinoma-with-negative-serum-thyroglobulin-and-neck-ultrasonography-after-ablation-a-prospective-study
#5
Marina Carvalho, Pedro Weslley Rosario, Gabriela Franco Mourão, Luis Fernando Faria Oliveira, Maria Regina Calsolari
BACKGROUND: Interference of antithyroglobulin antibodies (TgAb) with serum thyroglobulin (Tg) can occur even at detectable TgAb concentrations below the reference limit (borderline TgAb). Thus, borderline TgAb is considered positive TgAb in patients with thyroid cancer. This prospective study evaluated patients with papillary thyroid carcinoma with negative Tg and neck ultrasonography (US) after initial therapy and compared tumor persistence/recurrence and long-term Tg and TgAb behavior in those with borderline versus undetectable TgAb...
January 12, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29324929/our-solution-for-fusion-of-simultaneusly-acquired-whole-body-scintigrams-and-optical-images-as-usesful-tool-in-clinical-practice-in-patients-with-differentiated-thyroid-carcinomas-after-radioiodine-therapy-a-useful-tool-in-clinical-practice
#6
Milovan Matovic, Milica Jankovic, Marko Barjaktarovic, Marija Jeremic
OBJECTIVE: After radioiodine therapy of differentiated thyroid cancer (DTC) patients, whole body scintigraphy (WBS) is standard procedure before releasing the patient from the hospital. A common problem is the precise localization of regions where the iod-avide tissue is located. Sometimes is practically impossible to perform precise topographic localization of such regions. METHOD: In order to face this problem, we have developed a low-cost Vision-Fusion system for web-camera image acquisition simultaneously with routine scintigraphic whole body acquisition including the algorithm for fusion of images given from both cameras...
September 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29324909/effect-of-hypoparathyroid-on-bone-mineral-density-of-lumber-spine-in-postmenopausal-women-with-differentiated-thyroid-cancinoma
#7
Yongli Bai, Yanlei Huo, Fei Yu, Danyang Wang, Chao Ma
OBJECTIVE: To investigate the effect of hypoparathyroid on bone mineral density in postmenopausal women with differentiated thyroid carcinoma (DTC). SUBJECT AND METHODS: Postmenopausal women with postoperative DTC, and undergoing thyroid residual ablation or for metastases treatment were collected and followed for two years. They were divided into hypoparathyroid group (PTH<15pg/mL) and a normal cognitive group (PTH>15pg/mL). Bone mineral density (BMD) at the lumbar spine was analyzed using dual-energy X-ray absorptiometry (DXA) at baseline, 6, 12 and 24 months...
September 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29323252/clinical-value-of-99mtc-3prgd2-spect-ct-in-differentiated-thyroid-carcinoma-with-negative-131i-whole-body-scan-and-elevated-thyroglobulin-level
#8
Rui Gao, Guang-Jian Zhang, Yuan-Bo Wang, Yan Liu, Fan Wang, Xi Jia, Yi-Qian Liang, Ai-Min Yang
The aim of this study was to assess the usefulness of integrin imaging with 99mTc-PEG4-E[PEG4-c(RGDfK)]2 (99mTc-3PRGD2) single photon emission computed tomography (SPECT)/computed tomography (CT) in detecting recurrent disease in patients with differentiated thyroid cancer (DTC), negative radioiodine whole-body scan (WBS) and high serum thyroglobulin (Tg). Thirty-seven patients who underwent total thyroidectomy followed by radioactive iodine ablation and had negative radioiodine WBS but elevated Tg levels were included...
January 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29323074/small-cell-medullary-thyroid-carcinoma-a-diagnostic-dilemma
#9
Anuj Verma, Shubhada Kane, Sushant Vinarkar, Anil K D'Cruz
Small cell variant of medullary thyroid carcinoma (MTC) is a rare variant. In the past, primary thyroid lymphomas were thought to be small cell MTC (SCMTC). However, with the advent of immunohistochemistry, it was realized that SCMTC is rare. Our patient presented with neck mass for 1 year with an outside laboratory report of neoplastic lesion. His serum calcitonin levels were normal, but serum carcinoembryonic antigen (CEA) levels were high. He underwent total thyroidectomy and was diagnosed to have small cell variant of MTC...
October 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29322881/radiofrequency-ablation-of-primary-thyroid-carcinoma-efficacy-according-to-the-types-of-thyroid-carcinoma
#10
So Yeong Jeong, Jung Hwan Baek, Young Jun Choi, Sae Rom Chung, Tae Yon Sung, Won Gu Kim, Tae Yong Kim, Jeong Hyun Lee
OBJECTIVE: To evaluate the efficacy of ultrasound (US)-guided radiofrequency ablation (RFA) according to the types of thyroid carcinoma, particularly in patients with a high surgical risk. MATERIALS AND METHODS: Eight patients with nine tumors of pathologically proven papillary and anaplastic carcinoma were treated by US-guided RFA. Patients with primary thyroid carcinoma were divided into three groups; group 1: Anaplastic carcinoma, group 2: papillary macrocarcinoma, and group 3: papillary microcarcinoma...
January 11, 2018: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29321030/crabp1-c1ql1-and-lcn2-are-biomarkers-of-differentiated-thyroid-carcinoma-and-predict-extrathyroidal-extension
#11
Ricardo Celestino, Torfinn Nome, Ana Pestana, Andreas M Hoff, A Pedro Gonçalves, Luísa Pereira, Bruno Cavadas, Catarina Eloy, Trine Bjøro, Manuel Sobrinho-Simões, Rolf I Skotheim, Paula Soares
BACKGROUND: The prognostic variability of thyroid carcinomas has led to the search for accurate biomarkers at the molecular level. Follicular thyroid carcinoma (FTC) is a typical example of differentiated thyroid carcinomas (DTC) in which challenges are faced in the differential diagnosis. METHODS: We used high-throughput paired-end RNA sequencing technology to study four cases of FTC with different degree of capsular invasion: two minimally invasive (mFTC) and two widely invasive FTC (wFTC)...
January 10, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29320754/characteristics-of-cribriform-morular-variant-of-papillary-thyroid-carcinoma-in-post-chernobyl-affected-region
#12
Alfred King-Yin Lam, Mikhail Fridman
The aim is to study the characteristics of cribriform morular variant of papillary thyroid carcinoma (CMV-PTC) in patients living in radiation-affected area of Belarus. The clinical and pathological features of 35 patients with CMV-PTC from Belarus were studied and compared with those of conventional papillary thyroid carcinoma diagnosed in the same period. The patients with CMV-PTC were all females and were younger at presentation (mean age = 24) than those with conventional papillary thyroid carcinoma. Familial adenomatous polyposis (FAP) was identified in 20% of the patients with CMV-PTC...
January 7, 2018: Human Pathology
https://www.readbyqxmd.com/read/29319130/anaplastic-thyroid-carcinoma-with-rapid-thyrotoxicosis-case-report-and-the-review-of-literature
#13
Jacek Daroszewski, Katarzyna Paczkowska, Aleksandra Jawiarczyk-Przybyłowska, Marek Bolanowski, Michał Jeleń
INTRODUCTION: Anaplastic thyroid carcinoma (ATC) is one of the most aggressive human malignancies and constitutes approximately 1.6-5% of malignant neoplasms of thyroid. ATC usually presents with local symptoms due to rapidly enlarging thyroid mass, and has only seldom been reported to be a cause of thyrotoxicosis. Up to date only 9 cases of ATC presented with thyrotoxicosis have been described. CASE REPORT: We report a case of 66-year-old woman, who had had a large, euthyroid multinodular goiter for almost 50 years...
January 10, 2018: Endokrynologia Polska
https://www.readbyqxmd.com/read/29319129/cerebellar-metastasis-of-papillary-thyroid-carcinoma-detected-with-somatostatin-receptor-scintigraphy
#14
Rafal Czepczynski, Anna Wyszomirska, Maria Gryczynska, Ewelina Szczepanek-Parulska, Marek Ruchala
BACKGROUND: Distant metastases of papillary thyroid carcinoma (PTC) may lack the ability to concentrate radioiodine. In such cases, positive somatostatin receptor scintigraphy might be useful in demonstrating the expression of somatostatin receptors that are potential therapeutic targets. To date, only several cerebellar metastases from PTC have been reported in the literature. PATIENT FINDINGS: We present an 82-year-old female, in whom an asymptomatic cerebellar metastasis from PTC was diagnosed by the means of Tc-99m-EDDA/HYNIC-TOC scintigraphy four years following the initial diagnosis...
January 10, 2018: Endokrynologia Polska
https://www.readbyqxmd.com/read/29317955/pattern-of-thyroid-lesions-in-western-region-of-saudi-arabia-a-retrospective-analysis-and-literature-review
#15
Muhammad I Saeed, Amal Ali Hassan, Muhammad Ejaz Butt, Khalid Ali Baniyaseen, Muhammad I Siddiqui, Neda M Bogari, Faisal A Al-Allaf, Mohiuddin M Taher
Background: Ultrasonography (US) is being recognized as a traditional way of the diagnosis of various thyroid disorders, and this will help in detecting the thyroid tumors in early stage. Thyroid nodules are common and usually benign; steps to diagnose malignancy should include a careful clinical evaluation, laboratory tests, a thyroid US exam and a fine-needle aspiration (FNA) biopsy. Methods: A total of 173 registered cases were used for analysis in this study...
February 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29317480/mir-205-targets-angiogenesis-and-emt-concurrently-in-anaplastic-thyroid-carcinoma
#16
Haleh Vosgha, Armin Ariana, Robert Smith, Alfred Lam
The current study aims to evaluate for the first time the inhibitory roles of miR-205 in the pathogenesis of anaplastic thyroid carcinoma. In addition, we investigated the mechanisms by which miR-205 regulates angiogenesis and epithelial-to-mesenchymal transition (EMT) in cancer. Two anaplastic thyroid carcinoma cell lines were transfected with the expression vector pCMV-MIR-205. Selected markers of angiogenesis and EMT including vascular endothelial growth factor A (VEGF-A) and zinc-finger E-box-binding homeobox 1 (ZEB1) were investigated by Western blot...
January 9, 2018: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29317366/management-of-solitary-intracranial-metastases-of-differentiated-thyroid-carcinoma-11-pathologically-confirmed-cases-and-systematic-literature-review
#17
Mingyu Chen, Danqi Chen, Jian Xu, Ming Xu, Ping Zhong
BACKGROUND: Solitary intracranial metastases of differentiated thyroid carcinoma (DTC) are rare and the management is still controversial. This research is aim to seek for the suitable therapeutic methods of this disease. METHODS: We retrospectively studied 11 pathologically confirmed cases of solitary intracranial metastases of DTC in a single institution from January 2000 to December 2016 and systematically reviewed 52 cases of this disease out of 416 cases presented in the literature on Pubmed...
January 6, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29317047/histogram-analysis-of-greyscale-sonograms-to-differentiate-between-the-subtypes-of-follicular-variant-of-papillary-thyroid-cancer
#18
M-R Kwon, J H Shin, S Y Hahn, Y L Oh, J Y Kwak, E Lee, Y Lim
AIM: To evaluate the diagnostic value of histogram analysis using ultrasound (US) to differentiate between the subtypes of follicular variant of papillary thyroid carcinoma (FVPTC). MATERIALS AND METHODS: The present study included 151 patients with surgically confirmed FVPTC diagnosed between January 2014 and May 2016. Their preoperative US features were reviewed retrospectively. Histogram parameters (mean, maximum, minimum, range, root mean square, skewness, kurtosis, energy, entropy, and correlation) were obtained for each nodule...
January 6, 2018: Clinical Radiology
https://www.readbyqxmd.com/read/29316976/clinical-implications-of-the-braf-mutation-in-papillary-thyroid-carcinoma%C3%A2-and-chronic-lymphocytic-thyroiditis
#19
Woon Won Kim, Tae Kwun Ha, Sung Kwon Bae
BACKGROUND: The purpose of this study was to examine the possible prognostics and clinicopathologic characteristics underlying the BRAFV600E mutation and papillary thyroid carcinoma (PTC) coexisting or in absence of chronic lymphocytic thyroiditis (CLT). METHODS: This study was conducted on 172 patients who had undergone total thyroidectomy or unilateral total thyroidectomy for PTC; the patients were then examined for the BRAFV600E mutation using specimens obtained after their surgery from January 2013 to August 2015...
January 9, 2018: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29316404/the-cxcl12-cxcr4-axis-promotes-migration-invasion-and-emt-in-human-papillary-thyroid-carcinoma-b-cpap-cells-via-nf-%C3%AE%C2%BAb-signaling
#20
Yuanqiang Lin, Qingjie Ma, Lin Li, Hui Wang
Papillary thyroid carcinoma (PTC) is the most common thyroid malignancy involving local and distant metastasis. It is known that CXC chemokine ligand 12 (CXCL12) interacts specifically with CXC chemokine receptor 4 (CXCR4) to guide the migration of PTC cells. However, the signaling pathway downstream of the CXCL12/CXCR4 axis in PTC is not fully understood. In the present study, high expression of CXCR4 was detected in 38 out of 82 PTC specimens, and the expression level of CXCR4 was significantly correlated with the stage of PTC...
January 9, 2018: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
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