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https://www.readbyqxmd.com/read/29234951/zinc-finger-transcription-factor-odd-skipped-related-1-regulates-cranial-bone-formation
#1
Shinji Kawai, Masashi Yamauchi, Atsuo Amano
Knowledge of the molecular mechanisms of bone formation has been advanced by novel findings related to genetic control. Odd-skipped related 1 (Osr1) is known to play important roles in embryonic, heart, and urogenital development. To elucidate the in vivo function of Osr1 in bone formation, we generated transgenic mice overexpressing full-length Osr1 under control of its 2.8-kb promoter, which were smaller than their wild-type littermates. Notably, abnormalities in the skull of Osr1 transgenic mice were revealed by analysis of X-ray, skeletal preparation, and morphological findings, including round skull and cranial dysraphism...
December 12, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29230158/significant-improvement-of-clinical-symptoms-bone-lesions-and-bone-turnover-after-long-term-zoledronic-acid-treatment-in-patients-with-a-severe-form-of-camurati-engelmann-disease
#2
Giampiero I Baroncelli, Elena Ferretti, Cecilia M Pini, Benedetta Toschi, Rita Consolini, Silvano Bertelloni
Camurati-Engelmann disease (CED) is an ultrarare autosomal dominant bone dysplasia. Cortical thickening of the diaphyses of the long bones with narrowing of the medullary cavity are associated with bone pain, waddling gait, muscular weakness, easy fatigability, and a marfanoid body habitus. There is no specific treatment for CED. Nonsteroidal anti-inflammatory drugs or glucocorticoids are ineffective in improving bone lesions. A family with a mild to severe form of CED is described. Two patients received long-term bisphosphonate treatment: the 19-year-old female proband was treated with zoledronic acid for 2...
November 2017: Molecular Syndromology
https://www.readbyqxmd.com/read/29229438/pulsed-electromagnetic-fields-pemf-attenuate-changes-in-vertebral-bone-mass-architecture-and-strength-in-ovariectomized-mice
#3
Tao Lei, Zhuowen Liang, Feijiang Li, Chi Tang, Kangning Xie, Pan Wang, Xu Dong, Shuai Shan, Maogang Jiang, Qiaoling Xu, Erping Luo, Guanghao Shen
Pulsed electromagnetic fields (PEMF) has been investigated as a noninvasive alternative method to prevent bone loss for postmenopausal osteoporosis (OP), and the bone tissue involved in these studies are usually long bones such as femur and tibia in OP patients or rat models. However, few studies have investigated the effects of PEMF on the vertebral bone in mice with OP. This study aimed to investigate whether PEMF preserve lumbar vertebral bone mass, microarchitecture and strength in ovariectomized (OVX) mouse model of OP and its associated mechanisms...
December 8, 2017: Bone
https://www.readbyqxmd.com/read/29228681/cyclophosphamide-causes-osteoporosis-in-c57bl-6-male-mice-suppressive-effects-of-cyclophosphamide-on-osteoblastogenesis-and-osteoclastogenesis
#4
Dongfeng Zhao, Chenglong Wang, Yongjian Zhao, Bing Shu, Youji Jia, Shufen Liu, Hongshen Wang, Junli Chang, Weiwei Dai, Sheng Lu, Qi Shi, Yanping Yang, Yan Zhang, Yongjun Wang
The clinical evidence indicated that cyclophosphamide (CPD), one of the chemotherapy drugs, caused severe deteriorations in bones of cancer patients. However, the exact mechanisms by which CPD exerts effects on bone remodeling is not yet fully elucidated. Therefore, this study was performed to investigate the role and potential mechanism of CPD in osteoblastogenesis and osteoclastogenesis. Here it was found that CPD treatment (100mg/kg/day) for 7 days led to osteoporosis phenotype in male mice. CPD inhibited osteoblastogenesis as shown by decreasing the number and differentiation of bone mesenchymal stem cells (MSCs) and reducing the formation and activity of osteoblasts...
November 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29228439/beneficial-effects-of-low-level-laser-irradiation-on-senile-osteoporosis-in-rats
#5
C-T Zhu, T Li, P Zhang, M Zou, Q Guo, X-W Qu
OBJECTIVE: To investigate the effect of low-level laser irradiation (LLLI) on bone mineral density (BMD), bone structures, bone biomechanical properties and bone metabolism in senile osteoporosis, and to explore a relatively more secure and effective way to prevent and treat osteoporosis. MATERIALS AND METHODS: Sprague-Dawley (SD) male rats at different age stages (4 months old, 12 months old and 20 months old) were selected and randomly divided into six groups...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29223538/curcumin-induces-osteoblast-differentiation-through-mild-endoplasmic-reticulum-stress-mediated-such-as-bmp2-on-osteoblast-cells
#6
Hyo-Eun Son, Eun-Jung Kim, Won-Gu Jang
AIMS: Curcumin (diferuloylmethane or [1E,6E]-1,7-bis[4-hydroxy-3-methoxyphenyl]-1,6heptadiene-3,5-dione) is a phenolic natural product derived from the rhizomes of the turmeric plant, Curcuma longa. It is reported to have various biological actions such as anti-oxidative, anti-inflammatory, and anti-cancer effects. However, the molecular mechanism of osteoblast differentiation by curcumin has not yet been reported. MAIN METHODS: The cytotoxicity of curcumin was identified using the 3-(4,5-dimethylthiazol-2yl)-2,5-diphenyltetrazolium bromide (MTT) assay...
December 6, 2017: Life Sciences
https://www.readbyqxmd.com/read/29222846/influence-of-the-three-dimensional-culture-of-human-bone-marrow-mesenchymal-stromal-cells-within-a-macroporous-polysaccharides-scaffold-on-pannexin-1-and-pannexin-3
#7
Julien Guerrero, Hugo Oliveira, Rachida Aid, Reine Bareille, Robin Siadous, Didier Letourneur, Yong Mao, Joachim Kohn, Joëlle Amédée
Because cell interactions play a fundamental role for cell differentiation, we investigated the expression of Pannexin 1 and Pannexin 3 in human bone marrow mesenchymal stromal cells (HBMSCs) in a three-dimensional (3D) microenvironment provided by a polysaccharide-based macroporous scaffold. The pannexin (Panx) family consists of three members, Panx1, Panx2, and Panx3. The roles of pannexin large-pore ion and metabolite channels are recognized in many physiological and pathophysiological scenarios but the role of these proteins in human physiological processes is still under investigation...
December 9, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29218776/is-the-consumption-of-snail-meat-actually-healthy-an-analysis-of-the-osteotropic-influence-of-snail-meat-as-a-sole-source-of-protein-in-growing-rats
#8
R P Radzki, M Bieńko, P Polak, K Szkucik, M Ziomek, M Ostapiuk, J Bieniaś
The study was aimed at determining the osteotropic effects of diets containing snail meat as a sole protein source. In our experiment, we tested three different diets incorporating snail meat originating from Helix pomatia (HP), Cornu.aspesa maxima (CAM) and Cornu.aspersum aspersum (CAA) and compared these to a control diet (CON) in which casein was the source of protein. In all diets, the protein content amounted to 10%, as calculated on a dry weight basis. In the study, forty male Wistar rats with an initial body mass of 50 ± 2 g were randomly placed within the control and three experimental groups...
December 7, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/29216631/effect-of-cinacalcet-combined-with-calcitriol-on-the-clinical-outcome-and-bone-metabolism-in-patients-on-hemodialysis-with-severe-secondary-hyperparathyroidism
#9
Fang Yuan, Xing Chen, Chang Wang, Zheng Li, Hong Liu
OBJECTIVE: To observe the clinical outcome and the effect of bone metabolism of cinacalcet combined with calcitriol in maintenance hemodialysis (MHD) patients with severe secondary hyperparathyroidism (SHPT). METHODS: Thirty MHD patients with SHPT were enrolled into the study. All patients were given cinacalcet 25-75 mg and 0.5 μg calcitriol daily. Serum Ca, P, intact parathyroid hormone (iPTH), and bone metabolic markers were measured. The clinical symptoms and their changes were investigated...
December 7, 2017: Blood Purification
https://www.readbyqxmd.com/read/29215447/cross-sectional-study-of-four-serological-bone-turnover-markers-for-the-risk-assessment-of-medication-related-osteonecrosis-of-the-jaw
#10
Andre Peisker, Gregor F Raschke, Mina D Fahmy, Arndt Guentsch, Korosh Roshanghias, Kai C König, Stefan Schultze-Mosgau
BACKGROUND: Despite the benefits related to the use of bisphosphonates and denosumab, medication-related osteonecrosis of the jaw (MRONJ) is a serious complication. The purpose of this study was to investigate the utility of 4 biochemical markers including serum c-terminal telopeptide cross-link of type I collagen (s-CTX), serum osteocalcin (s-OC), serum parathormon (s-PTH), and serum bone-specific alkaline phosphatase (s-BAP) as useful clinical tools to help assess the risk for MRONJ prior to invasive oral surgery...
December 6, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29212906/osteoblasts-are-rapidly-ablated-by-virus-induced-systemic-inflammation-following-lymphocytic-choriomeningitis-virus-or-pneumonia-virus-of-mice-infection-in-mice
#11
Steven Maltby, Alyssa J Lochrin, Bianca Bartlett, Hock L Tay, Jessica Weaver, Ingrid J Poulton, Maximilian W Plank, Helene F Rosenberg, Natalie A Sims, Paul S Foster
A link between inflammatory disease and bone loss is now recognized. However, limited data exist on the impact of virus infection on bone loss and regeneration. Bone loss results from an imbalance in remodeling, the physiological process whereby the skeleton undergoes continual cycles of formation and resorption. The specific molecular and cellular mechanisms linking virus-induced inflammation to bone loss remain unclear. In the current study, we provide evidence that infection of mice with either lymphocytic choriomeningitis virus (LCMV) or pneumonia virus of mice (PVM) resulted in rapid and substantial loss of osteoblasts from the bone surface...
December 6, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29208404/naringin-prevents-bone-loss-in-a-rat-model-of-type-1-diabetes-mellitus
#12
M Rivoira, V Rodríguez, G Picotto, R Battaglino, N Tolosa de Talamoni
The aim of this work was to know whether naringin (NA) could prevent the bone complications in a model of streptozotocin (STZ) induced diabetes. Rats were divided in: 1) controls, 2) STZ-rats, 3) STZ-rats treated with 40 mg NA/kg, and 4) STZ-rats treated with 80 mg NA/kg. BMD and BMC were performed by DEXA. Bone histomorphometry and histology as well as TRAP staining were done in tibia. Osteocalcin (OCN) was determined in bone and serum. Glutathione content and SOD and catalase activities were assayed in bone marrow from femur...
December 2, 2017: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29208188/the-antiosteoporosis-effect-of-icariin-in-ovariectomized-rats-a-systematic-review-and-meta-analysis
#13
Yu Liu, Haojiang Zuo, Xuewei Liu, Jingyuan Xiong, Xiaofang Pei
Herba Epimedii (Yinyanghuo or Horny Goat Weed) is a traditional Chinese medicine widely used in treating osteoporosis. As the major active component, icariin is intensively investigated in the prevention and treatment of osteoporosis in ovariectomized rats. However, misleading conclusions can be generated in animal studies with various experimental designs. Therefore, a systematic review and meta-analysis was performed to evaluate the efficacy of icariin against osteoporosis in ovariectomized rats. PubMed, EMBASE and Chinese National Knowledge Infrastructure databases were searched to identify studies of icariin in ovariectomized rats...
November 30, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/29207066/erythropoietin-induces-the-osteogenesis-of-periodontal-mesenchymal-stem-cells-from-healthy-and-periodontitis-sources-via-activation-of-the-p38-mapk-pathway
#14
Liying Wang, Fan Wu, Yang Song, Yinzhong Duan, Zoulin Jin
Erythropoietin (Epo), a hematopoietic hormone, has multiple biological functions. Recently, the positively osteogenic effects of Epo on mesenchymal stem cells (MSCs) have attracted broad interest. However, the effects of Epo on the osteogenesis of human periodontal ligament tissue‑derived mesenchymal stem cells (hPDLSCs) and periodontitis mesenchymal stem cells (pPDLSCs) from patients with periodontitis remain unknown. In the present study, osteogenic effects of Epo on hPDLSCs and pPDLSCs were investigated, and the results suggested that the effects were mediated by promoting the expression of runt related transcription factor 2, alkaline phosphatase (ALP) and osteocalcin...
November 28, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29207032/autophagy-relieves-the-function-inhibition-and-apoptosis%C3%A2-promoting-effects-on-osteoblast-induced-by-glucocorticoid
#15
Yudi Han, Lihai Zhang, Yaling Xing, Licheng Zhang, Xiaojuan Chen, Peifu Tang, Zhongbin Chen
Autophagy may be a major mechanism by which osteoblasts (OBs) protect against the negative effects of chronic glucocorticoid (GC) usage. OBs are closely associated with the remodeling that occurs in GC‑induced osteoporosis (GIO). In osteocytes, in response to stress induced by GCs, several pathways are activated, including cell necrosis, apoptosis and autophagy. However, the role of autophagy in OBs following treatment with excess GCs has not been addressed. In the current study, confocal microscopy observation of green fluorescent protein‑microtubule‑associated protein 1 light chain 3β (LC3) punctuate, and western blotting for LC3Ⅱ and Beclin 1 were performed for detection of autophagy in the MC3T3‑E1 osteoblastic cell line...
November 17, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29205072/enamel-matrix-proteins-regulate-hypoxia-induced-cellular-biobehavior-and-osteogenic-differentiation-in-human-periodontal-ligament-cells
#16
Z C Song, S Li, J C Dong, M J Sun, X L Zhang, R Shu
Hypoxia is a crucial microenvironment for inflamed periodontal tissue and periodontal wound healing. Enamel matrix proteins (EMPs) potentially can promote the formation of new periodontium. The effects of EMPs on periodontal ligament cells under hypoxia, however, remain unclear. We investigated the effects of EMPs on cellular biobehavior and osteogenic differentiation of human periodontal ligament cells (hPDLCs) under hypoxia. Under cobalt chloride (CoCl2)-induced hypoxia, cellular biobehavior of hPDLCs, including proliferation, attachment, spreading, and migration with or without EMPs, was evaluated by 3-(4, 5-dimethylthiazol- 2-yl)-2, 5-diphenyl tetrazolium bromide (MTT), cell counting, spreading area measurement and wound scratch assay...
December 5, 2017: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
https://www.readbyqxmd.com/read/29204135/recombinant-uncarboxylated-osteocalcin-per-se-enhances-mouse-skeletal-muscle-glucose-uptake-in-both-extensor-digitorum-longus-and-soleus-muscles
#17
Xuzhu Lin, Lewan Parker, Emma Mclennan, Xinmei Zhang, Alan Hayes, Glenn McConell, Tara C Brennan-Speranza, Itamar Levinger
Emerging evidence suggests that undercarboxylated osteocalcin (ucOC) improves muscle glucose uptake in rodents. However, whether ucOC can directly increase glucose uptake in both glycolytic and oxidative muscles and the possible mechanisms of action still need further exploration. We tested the hypothesis that ucOC per se stimulates muscle glucose uptake via extracellular signal-regulated kinase (ERK), adenosine monophosphate-activated protein kinase (AMPK), and/or the mechanistic target of rapamycin complex 2 (mTORC2)-protein kinase B (AKT)-AKT substrate of 160 kDa (AS160) signaling cascade...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29202447/bone-forming-peptide-3-induces-osteogenic-differentiation-of-bone-marrow-stromal-cells-via-regulation-of-the-erk1-2-and-smad1-5-8-pathways
#18
Jun Sik Lee, Mi Eun Kim, Jong Keun Seon, Ju Yeon Kang, Taek Rim Yoon, Yong-Duk Park, Hyung Keun Kim
A bone-remodeling imbalance induced by increased bone resorption and osteoclast formation causes skeletal diseases such as osteoporosis. Induction of osteogenic differentiation of bone marrow stromal cells (BMSCs) leads to bone regeneration. Many researchers have tried to develop new adjuvants as specific stimulators of bone regeneration for therapeutic use in patients with bone resorption. We tried to develop a new adjuvant that has stronger osteogenic differentiation-promoting activity than bone morphogenetic proteins (BMPs)...
November 22, 2017: Stem Cell Research
https://www.readbyqxmd.com/read/29201212/anti-aging-effect-of-fullerenol-on-skin-aging-through-derived-stem-cells-in-a-mouse-model
#19
Wei Li, Ning Li, Bing Sui, Daping Yang
Fullerenol is similar to graphite in terms of structure. In the present study, the anti-aging effect of fullerenol on skin through derived stem cells in a mouse model was assessed and the potential mechanism of fullerenol was investigated. The anti-aging effect of fullerenol effectively inhibited the retention rate of transplanted adipose-derived stem cells and increased the thickness of the dermal portion of skin and collagen ratio in mice. The effect of fullerenol on the proliferation of stem cells was observed...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29201210/protective-effects-of-resveratrol-on-osteoporosis-via-activation-of-the-sirt1-nf-%C3%AE%C2%BAb-signaling-pathway-in-rats
#20
Xiaowei Wang, Liaobin Chen, Wei Peng
The aim of the present study was to determine the protective effects of resveratrol on a rat model of osteoporosis and examine the associated mechanisms of its action. Rats were randomized into the following groups: Control, osteoporosis, osteoporosis + low-dose resveratrol, osteoporosis + middle-dose resveratrol and osteoporosis + high-dose resveratrol groups. Resveratrol treatment was administered 7 days after surgery for 8 weeks. ELISA assay was used to analyze alkaline phosphatase (ALP) and osteocalcin (OC) protein levels...
November 2017: Experimental and Therapeutic Medicine
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