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https://www.readbyqxmd.com/read/29139249/-clinical-features-analysis-of-qingkailing-injection-for-adolescent-patients-based-on-real-world-his
#1
Li-Zhen Chen, Yan-Ming Xie, Lian-Xin Wang, Yin Zhang, Qun Wang, Ping-Ping Jia, Bo Feng
To explore the clinical application features of Qingkailing injection for adolescent patients. This study was based on the information from the hospitalized patients in 1998-2011 in HIS (hospital information system) of 16 tertiary hospitals in China. 615 adolescent patients with Qingkailing injection were used to investigate the clinical characteristics of Qingkailing injection. Apriori algorithm was adopted to establish the model, and Clementine 12.0 was used for correlation analysis. The results showed that male patients (355 cases) were more than female patients (243 cases); the age of the most patients was under 14 years old, with an average age of 9...
August 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29136293/efficacy-and-safety-of-tofacitinib-for-moderate-to-severe-plaque-psoriasis-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#2
REVIEW
C-M Kuo, T-H Tung, S-H Wang, C-C Chi
The effects of tofacitinib in treating moderate-to-severe plaque psoriasis were unclear. We aimed to assess the effects of tofacitinib in treating moderate-to-severe plaque psoriasis. We searched PubMed, Cochrane Central Register of Controlled Trials, and EMBASE for relevant randomised controlled trials (RCTs), and conducted a systematic review and meta-analysis. Four RCTs with 2,724 participants were included. Compared to placebo, tofacitinib significantly improved psoriasis (≥ 75% reduction in the Psoriasis Area and Severity Index score: 5 mg BID: risk difference (RD) 0...
November 14, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29135841/severe-warm-autoimmune-hemolytic-anemia-in-a-7-month-old-infant-associated-with-a-mycoplasma-pneumoniae-infection
#3
Cierra Wandro, Leili Dolatshahi, Douglas Blackall
A 7-month-old female infant had clinical and laboratory evidence of severe warm autoimmune hemolytic anemia. She also had clinical evidence of an upper respiratory tract infection with molecular detection of Mycoplasma pneumoniae. Although reticulocytopenic initially, she responded to red blood cell transfusion, steroids, and intravenous immunoglobulin and remains well today. With the increasing use of multiplex respiratory viral and bacterial pathogen detection systems, the rare association described in this report may prove to be more common than previously thought and may provide insight into the pathogenesis and clinical consequences of red blood cell autoantibodies...
November 13, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29135336/a-retrospective-observational-analysis-of-post-pandemic-influenza-related-outcomes-in-the-united-kingdom-2010-2014
#4
Sankarasubramanian Rajaram, Witold Wiecek, Richard Lawson, Betina Blak, Yanli Zhao, Judith Hackett, Robert Brody, Tehseen Salimi, Billy Amzal, Vishal Patel
This study set out to evaluate influenza- and respiratory-related illnesses recorded during primary care physician consultations in England following the H1N1 pandemic in 2009 and to enable the development of a dynamic disease model. Data were obtained from the Clinical Practice Research Datalink of primary care records over four influenza seasons (2010-2014). The primary outcome of the study was incidence of influenza- and respiratory-related diagnoses, calculated per practice and by season and age group. Upper respiratory tract infection diagnoses were most frequently recorded (mean seasonal practice level incidence; 3,762 consultations per 100,000 [SD = 1,989]), and influenza-related diagnoses were least frequently recorded across all seasons, except one...
November 14, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29134822/treating-moderate-to-severe-plaque-psoriasis-with-guselkumab-a-review-of-phase-ii-and-phase-iii-trials
#5
Seth T Howell, Leah A Cardwell, Steven R Feldman
OBJECTIVE: Guselkumab, an anti-interleukin-23 monoclonal antibody was recently approved for the treatment of patients with moderate-to-severe plaque psoriasis. This article will review the available phase II and phase III guselkumab clinical trial data. DATA SOURCES: A PubMed search was conducted using the terms guselkumab, interleukin-23, psoriasis, adalimumab, and ustekinumab (January 2014 to August 2017). STUDY SELECTION AND DATA EXTRACTION: Articles detailing the results of phase II and phase III clinical trials were selected for review...
November 1, 2017: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29134096/co-infection-does-not-predict-disease-signs-in-gopherus-tortoises
#6
Chava L Weitzman, Ryan Gov, Franziska C Sandmeier, Sarah J Snyder, C Richard Tracy
In disease ecology, the host immune system interacts with environmental conditions and pathogen properties to affect the impact of disease on the host. Within the host, pathogens may interact to facilitate or inhibit each other's growth, and pathogens interact with different hosts differently. We investigated co-infection of two Mycoplasma and the association of infection with clinical signs of upper respiratory tract disease in four congeneric tortoise host species (Gopherus) in the United States to detect differences in infection risk and disease dynamics in these hosts...
October 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/29133669/severe-gemella-haemolysans-endophthalmitis-following-ranibizumab-intravitreal-injection
#7
Silvia Olivia Salceanu, Sarah Levy, Richard Cunningham, Kwabena Frimpong-Ansah
Gemella haemolysans is a commensal of the upper respiratory tract that is rarely involved in ocular pathology. We present a unique case of endophthalmitis with negative cultures and positive 16s ribosomal ribonucleic acid gene sequencing showing G. haemolysans infection after an intravitreal ranibizumab injection for wet age-related macular degeneration.
November 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29121208/dynamics-of-bacterial-colonization-with-streptococcus-pneumoniae-haemophilus-influenzae-and-moraxella-catarrhalis-during-symptomatic-and-asymptomatic-viral-upper-respiratory-infection
#8
Gregory P DeMuri, James E Gern, Jens C Eickhoff, Susan V Lynch, Ellen R Wald
Background: Virus is detected in about 80% of upper respiratory tract infections (URIs) in children and is also detectable in the nasopharynx of 30% of asymptomatic children. The effect of asymptomatic viral infection on the dynamics of bacterial density and colonization of the nasopharynx has not been reported. Objective: To assess the presence and density of Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis in the nasopharynx of 4 to 7 year old children during URI and when well...
November 7, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29119851/clinical-characteristics-of-children-infected-with-enterovirus-d68-in-an-outpatient-clinic-and-the-association-with-bronchial-asthma
#9
Tsutomu Itagaki, Yoko Aoki, Yohei Matoba, Shizuka Tanaka, Tatsuya Ikeda, Katsumi Mizuta, Yoko Matsuzaki
BACKGROUND: All reports of increases in severe respiratory disease associated with human enterovirus D68 (EV-D68) are from hospital settings. However, there are few reports describing clinical characteristics in less severely affected populations. METHODS: We conducted a retrospective observational study from January 2010 to December 2015 in Yamagata, Japan. Using regional passive surveillance, 5794 respiratory specimens were collected from children who initially presented to an outpatient clinic with acute respiratory symptoms...
November 9, 2017: Infectious Diseases
https://www.readbyqxmd.com/read/29115723/patterns-of-paediatric-emergency-presentations-to-a-tertiary-referral-centre-in-the-northern-territory
#10
Davina Buntsma, Anna Lithgow, Evan O'Neill, Didier Palmer, Peter Morris, Jason Acworth, Franz E Babl
OBJECTIVE: To describe epidemiological data concerning paediatric attendances at the ED of Royal Darwin Hospital (RDH). METHODS: We conducted a retrospective cohort study of paediatric emergency presentations to the RDH ED during 2004 and 2013. Epidemiological data, including demographics, admission rates and diagnostic grouping, were analysed using descriptive and comparative statistical methods. We compared data with findings from a baseline epidemiological study by the Paediatric Research in Emergency Departments International Collaborative (PREDICT) conducted in 2004...
November 8, 2017: Emergency Medicine Australasia: EMA
https://www.readbyqxmd.com/read/29114398/multi-system-manifestations-of-mycoplasma-pneumoniae-infection-in-a-young-patient
#11
Ibrahim Al Busaidi, Mohammed Al-Amin, Shadin Ibrahim, Abdullah Balkhair, Zied Gaifer
Introduction.Mycoplasma pneumoniae is a small cell-wall-lacking bacterium that belongs to the mycoplasma (Mollicutes) prokaryote micro-organisms. It is a common cause of both upper and lower respiratory tract infections in all age groups. Respiratory illness is the most common manifestation of M. pneumoniae infection; however, extrapulmonary involvement may be present or predominant. The skin, mucus membranes, central nervous system, cardiovascular system, haematopoietic system, kidneys and musculoskeletal system are the most commonly involved extrapulmonary sites...
September 2017: JMM Case Reports
https://www.readbyqxmd.com/read/29114252/cd335-nkp46-t-cell-recruitment-to-the-bovine-upper-respiratory-tract-during-a-primary-bovine-herpesvirus-1-infection
#12
Rahwa A Osman, Philip John Griebel
Bovine natural killer (NK) cells were originally defined by the NK activation receptor CD335 [natural killer cell p46-related protein (NKp46)], but following the discovery of NKp46 expression on human T-cells, the definition of conventional bovine NK cells was modified to CD335(+)CD3(-) cells. Recently, a bovine T-cell population co-expressing CD335 was identified and these non-conventional T-cells were shown to produce interferon (IFN)-γ and share functional properties with both conventional NK cells and T-cells...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29106820/development-and-function-of-the-mucosal-immune-system-in-the-upper-respiratory-tract-of-neonatal-calves
#13
Rahwa Osman, Nilusha Malmuthuge, Patricia Gonzalez-Cano, Philip Griebel
Respiratory infections remain the second most common cause of clinical disease and mortality in newborn calves, which has led to increased interest in using vaccines early in life to mitigate this risk. Intranasal vaccination of neonatal calves can be an effective strategy to circumvent vaccine interference by maternal antibody, but this raises questions regarding onset of immune competence in the upper respiratory tract (URT) following birth. Little is known, however, about the development and function of mucosa-associated lymphoid tissue (MALT) in the URT of newborn calves and what factors, including the commensal microbiome, contribute to this early development...
November 6, 2017: Annual Review of Animal Biosciences
https://www.readbyqxmd.com/read/29104937/novel-genes-required-for-the-fitness-of-streptococcus-pyogenes-in-human-saliva
#14
Luchang Zhu, Amelia R L Charbonneau, Andrew S Waller, Randall J Olsen, Stephen B Beres, James M Musser
Streptococcus pyogenes (group A streptococcus [GAS]) causes 600 million cases of pharyngitis each year. Despite this considerable disease burden, the molecular mechanisms used by GAS to infect, cause clinical pharyngitis, and persist in the human oropharynx are poorly understood. Saliva is ubiquitous in the human oropharynx and is the first material GAS encounters in the upper respiratory tract. Thus, a fuller understanding of how GAS survives and proliferates in saliva may provide valuable insights into the molecular mechanisms at work in the human oropharynx...
November 2017: MSphere
https://www.readbyqxmd.com/read/29102433/effect-of-vitamin-d-supplementation-on-non-skeletal-disorders-a-systematic-review-of-meta-analyses-and-randomised-trials
#15
REVIEW
Philippe Autier, Patrick Mullie, Alina Macacu, Miruna Dragomir, Magali Boniol, Kim Coppens, Cécile Pizot, Mathieu Boniol
Randomised trials reported up to Dec 31, 2012, did not confirm that vitamin D supplementation could protect from non-skeletal health conditions affecting adults, as was expected on the basis of data from observational studies. To examine whether the more recently published meta-analyses and trials would change past conclusions, we systematically reviewed meta-analyses of vitamin D supplementation and non-skeletal disorders published between Jan 1, 2013, and May 31, 2017, that included study participants of all ages, including pregnant women...
October 25, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/29102353/effect-of-a-training-and-educational-intervention-for-physicians-and-caregivers-on-antibiotic-prescribing-for-upper-respiratory-tract-infections-in-children-at-primary-care-facilities-in-rural-china-a-cluster-randomised-controlled-trial
#16
Xiaolin Wei, Zhitong Zhang, John D Walley, Joseph P Hicks, Jun Zeng, Simin Deng, Yu Zhou, Jia Yin, James N Newell, Qiang Sun, Guanyang Zou, Yan Guo, Ross E G Upshur, Mei Lin
BACKGROUND: Inappropriate antibiotic prescribing contributes to the generation of drug resistance worldwide, and is particularly common in China. We assessed the effectiveness of an antimicrobial stewardship programme aiming to reduce inappropriate antibiotic prescribing in paediatric outpatients by targeting providers and caregivers in primary care hospitals in rural China. METHODS: We did a pragmatic, cluster-randomised controlled trial with a 6-month intervention period...
October 25, 2017: Lancet Global Health
https://www.readbyqxmd.com/read/29102352/reducing-antibiotic-prescriptions-for-childhood-upper-respiratory-tract-infections
#17
Gary W K Wong
No abstract text is available yet for this article.
October 25, 2017: Lancet Global Health
https://www.readbyqxmd.com/read/29101282/a-population-based-prospective-cohort-study-examining-the-influence-of-early-life-respiratory-tract-infections-on-school-age-lung-function-and-asthma
#18
Evelien R van Meel, Herman T den Dekker, Niels J Elbert, Pauline W Jansen, Henriëtte A Moll, Irwin K Reiss, Johan C de Jongste, Vincent W V Jaddoe, Liesbeth Duijts
BACKGROUND: Early-life respiratory tract infections could affect airway obstruction and increase asthma risk in later life. However, results from previous studies are inconsistent. OBJECTIVE: We examined the associations of early-life respiratory tract infections with lung function and asthma in school-aged children. METHODS: This study among 5197 children born between April 2002 and January 2006 was embedded in a population-based prospective cohort study...
November 3, 2017: Thorax
https://www.readbyqxmd.com/read/29099932/the-role-of-b-cells-in-carriage-and-clearance-of-mycoplasma-pneumoniae-from-the-respiratory-tract-of-mice
#19
Patrick M Meyer Sauteur, Ruben C A de Groot, Silvia C Estevão, Theo Hoogenboezem, Adrianus C J M de Bruijn, Marcel Sluijter, Marjolein J W de Bruijn, Ismé M De Kleer, Rien van Haperen, Judith M A van den Brand, Debby Bogaert, Pieter L A Fraaij, Cornelis Vink, Rudi W Hendriks, Janneke N Samsom, Wendy W J Unger, Annemarie M C van Rossum
Carriage of Mycoplasma pneumoniae (Mp) in the nasopharynx is considered a prerequisite for pulmonary infection. Interestingly, Mp carriage is also detected after infection. While B cells are known to be involved in pulmonary Mp clearance, their role in Mp carriage is unknown. We here show in a mouse model that Mp persists in the nose after pulmonary infection, similar to humans. Infection of mice enhanced Mp-specific immunoglobulin (Ig) M and IgG levels in serum and bronchoalveolar lavage fluid. However, nasal washes only contained elevated Mp-specific IgA...
November 1, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29096338/liver-abscess-and-sepsis-caused-by-clostridium-perfringens-and-klebsiella-oxytoca
#20
Christoph Paasch, Stefan Wilczek, Martin W Strik
INTRODUCTION: Clostridium (C) perfringens and Klebsiella (K) oxytoca are pathogenous human bacteria. Due to the production of several toxins C. perfringens is virulent by causing i.a. the necrotizing fasciitis, gas gangrene and hepatic abscess. K. oxytoca mostly causes infections of the respiratory and gastrointestinal tract. PRESENTATION OF CASE: We are presenting the case of a male patient at the age of 64, who suffered from nausea and progressive pain in the right upper abdomen...
October 26, 2017: International Journal of Surgery Case Reports
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