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Wheezing baby

Mingyuan Han, Jun Young Hong, Suraj Jaipalli, Charu Rajput, Jing Lei, Joanna L Hinde, Qiang Chen, Natalie M Hershenson, J Kelley Bentley, Marc B Hershenson
Early-life wheezing-associated infections with rhinovirus (RV) have been associated with asthma development in children. We have shown that RV infection of six day-old mice induces mucous metaplasia and airways hyperresponsiveness which is dependent on IL-13, IL-25 and type 2 innate lymphoid cells (ILC2s). Infection of immature mice fails to induce lung IFN-γ expression, in contrast to mature 8 week-old mice with a robust IFN-γ response, consistent with the notion that deficient IFN-γ production in immature mice permits RV-induced type 2 immune responses...
September 28, 2016: American Journal of Respiratory Cell and Molecular Biology
Yoshie Ochiai, Kunihiko Joo, Tatsushi Onzuka, Atsuhiro Nakashima, Yusaku Nagatomo, Mamie Watanabe, Jun Muneuchi
We present a very rare case of bilateral ductus arteriosus in transposition of the great arteries with right aortic arch and aberrant retroesophageal left subclavian artery (SCA). Around 1 month after the successful arterial switch operation, the baby showed wheezing and retractive breathing. The computed tomography revealed that trachea and esophagus were sandwiched between the posterior displaced ascending aorta and the origin of the retroesophageal aberrant left SCA, the so-called Kommerell diverticulum (KD)...
October 2016: Annals of Thoracic Surgery
Elena Priante, Laura Moschino, Veronica Mardegan, Paolo Manzoni, Sabrina Salvadori, Eugenio Baraldi
Despite notable advances in the survival and management of preterm infants in recent decades, chronic lung disease remains a common complication. Approximately one in three infants born preterm (< 32 weeks of gestation) are hospitalized with respiratory problems (mainly due to infections) in their first 2 years of life, and the risk of childhood wheezing is three times higher in this population. By comparison with infants born at term, there seems to be a higher incidence of respiratory morbidity in those born preterm, even in the absence of bronchopulmonary dysplasia (BPD) and in late-preterm babies...
September 2016: American Journal of Perinatology
Rie Nishikata, Naho Kato, Miwako Suto, Mami Rinnou, Ikubumi Mizusawa, Naohito Kuroda
Ventricular septal defect (VSD) has a relatively non-aggressive clinical course; either spontaneous closure or causing congestive heart failure treatable with surgical intervention. We present two autopsy cases of sudden infant deaths from clinically undiagnosed VSDs. Case 1 was an 18-day-old boy. As the deceased coughed and became limp after feeding, he was carried to a hospital. Heart murmur was not auscultated there, so he was brought back to home. He presented severe dyspnea and then he was pronounced dead the next day...
September 2016: Legal Medicine
Nicla A Varnier, Sarah Chwah, Trent Miller, Franziska Pettit, Mark Brown, David Rees, Amanda Henry
BACKGROUND: Shortness of breath is a common physiological pregnancy presentation, secondary to both hormonal and mechanical effects. Its pathological causes are common (asthma exacerbation or infection); new-onset cardiac pathology is rarely considered. CASE: JC, a 39-year old G4P2T1, presented at 34 weeks' gestation with shortness of breath unrelieved by salbutamol. History included asthma, poly-drug abuse and smoking. Initial presentation was consistent with asthma exacerbation and she was treated as such...
September 2015: Obstetric Medicine
T Batool, P L Reece, K M Schulze, K M Morrison, S A Atkinson, S S Anand, K K Teo, J A Denburg, M M Cyr
Prenatal and early-life environmental exposures play a key role in the development of atopy and allergic disease. The Family Atherosclerosis Monitoring In earLY life Study is a general, population-based Canadian birth cohort that prospectively evaluated prenatal and early-life traits and their association with atopy and/or allergic disease. The study population included 901 babies, 857 mothers and 530 fathers. Prenatal and postnatal risk factors were evaluated through questionnaires collected during the antenatal period and at 1 year...
July 25, 2016: Journal of Developmental Origins of Health and Disease
Lidia Giúdici, Vivian Susana Bokser, Maximiliano Alejo Maricic, Sergio G Golombek, Claudia Cecilia Ferrario
AIM: The aims of this Argentinian study were to describe and analyse the outcomes of a continuous interdisciplinary follow-up programme of patients with gastroschisis. METHODS: This was a prospective, longitudinal study of babies with gastroschisis admitted from 1 November 2003 to 31 October 2014, and this paper presents results at one, three and six years of age. Matched-pairs analyses were carried out when they were one and six. RESULTS: We enrolled 62 babies and assessed 52 at one year of age, 34 at three years and 17 at six years...
June 2016: Acta Paediatrica
Kelvin D MacDonald, Kimberly K Vesco, Kristine L Funk, Jerena Donovan, Thuan Nguyen, Zunqiu Chen, Jodi A Lapidus, Victor J Stevens, Cindy T McEvoy
RATIONALE: Maternal prepregnancy obesity has been associated with early wheeze and childhood asthma in their offspring. Some of these studies have been in minority, urban, and disadvantaged populations using parental recall and questionnaires. The association of maternal prepregnancy obesity with bronchodilator dispensing to their offspring, in a primarily insured, non-urban, White population in the United States is unknown. OBJECTIVES AND METHODS: We conducted a retrospective cohort study using pharmacy dispensing data from the electronic medical records of a large United States health maintenance organization to examine the relationship between maternal prepregnancy body mass index (BMI) and inhaled bronchodilator dispensing in the offspring to 4 years of age...
August 2016: Pediatric Pulmonology
I Alvarez-Alvarez, H Niu, I Aguinaga-Ontoso, F Guillen-Grima
BACKGROUND: Wheezing in the first year of life affects the baby's and family's quality of life. Risk factors such as male gender, nursery attending or a family history of asthma, and protective factors such as breastfeeding more than six months have been previously described. The aim of this study is to study the prevalence and risk factors for wheezing ever and recurrent wheezing in the first year of life in infants in the region of Pamplona, Spain. MATERIAL AND METHODS: This cross-sectional study was part of the International Study of Wheezing in Infants (Estudio Internacional de Sibilancias en Lactantes, EISL)...
September 2016: Allergologia et Immunopathologia
Jennifer A Namazy, Michael Schatz
INTRODUCTION: Pregnancy may be complicated by new onset or pre-existing asthma. This article reviews the recognition and management of asthma during pregnancy, paying close attention to the general principles of asthma medication use during pregnancy. Asthma is one of the most common potentially serious medical problems to complicate pregnancy, and asthma may adversely affect both maternal quality of life and perinatal outcomes. Therefore, optimal management of asthma during pregnancy is important for both mother and baby...
2015: Expert Opinion on Pharmacotherapy
Hamilton Rosendo Fogaça, Fernando Augusto de Lima Marson, Adyléia Aparecida Dalbo Contrera Toro, Dirceu Solé, José Dirceu Ribeiro
OBJECTIVE: To determine, in a sample of infants, the prevalence of and risk factors for occasional wheezing (OW) and recurrent wheezing-wheezy baby syndrome (WBS). METHODS: Parents of infants (12-15 months of age) completed the International Study of Wheezing in Infants questionnaire. RESULTS: We included 1,269 infants residing in the city of Blumenau, Brazil. Of those, 715 (56.34%) had a history of wheezing, which was more common among boys...
November 2014: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
Jennifer A Namazy, Christina Chambers, Michael Schatz
INTRODUCTION: Pregnancy may be complicated by new onset or preexisting asthma. Asthma is one of the most common potentially serious medical problems to complicate pregnancy, and it may adversely affect both maternal quality of life and perinatal outcomes. Optimal management of asthma during pregnancy is thus important for both mother and baby. AREAS COVERED: This article reviews the recognition and management of asthma during pregnancy, paying close attention to the general principles of asthma medication use during pregnancy...
December 2014: Expert Opinion on Drug Safety
Rebecca Farley, Geoffrey K P Spurling, Lars Eriksson, Chris B Del Mar
BACKGROUND: Bronchiolitis is a serious, potentially life-threatening respiratory illness commonly affecting babies. It is often caused by respiratory syncytial virus (RSV). Antibiotics are not recommended for bronchiolitis unless there is concern about complications such as secondary bacterial pneumonia or respiratory failure. Nevertheless, they are often used. OBJECTIVES: To evaluate the effectiveness of antibiotics for bronchiolitis in children under two years of age compared to placebo or other interventions...
October 9, 2014: Cochrane Database of Systematic Reviews
A de Vries, R M Reynolds, J R Seckl, M van der Wal, G J Bonsel, T G M Vrijkotte
Rates of obesity are increasing in women of child bearing age with negative impacts on maternal and offspring health. Emerging evidence suggests in utero origins of respiratory health in offspring of obese mothers but mechanisms are unknown. Changes in maternal cortisol levels are one potential factor as cortisol levels are altered in obesity and cortisol is separately implicated in development of offspring wheeze. We aimed to assess whether increased pre-pregnancy maternal body mass index (BMI) was associated with offspring early life wheezing, and whether this was mediated by altered cortisol levels in the mother...
October 2014: Journal of Developmental Origins of Health and Disease
Oe Keag, Sj Stock, J Norman
: Rates of caesarean section (CS) continue to rise in the UK. CS on maternal request is now endorsed by NICE, with NICE emphasising the importance of informed decision-making. The short-term consequences of CS for mother and baby are summarized in the NICE guideline on caesarean section. However, the long-term consequences of CS are less frequently discussed with women. We searched Medline, Embase, Cochrane and Google Scholar databases for randomised controlled trials and prospective cohort studies comparing childhood outcomes following primary CS and vaginal delivery...
June 2014: Archives of Disease in Childhood. Fetal and Neonatal Edition
Moushumi Lodh, Anand Kerketta Joshi
The diagnostic criteria for cystic fibrosis require the presence of 1 or more typical clinical features, a family history of cystic fibrosis, or a positive newborn screening test, plus laboratory evidence of the cystic fibrosis transmembrane conductance regulator dysfunction. However the present case was an adopted baby with persistent pneumonia since birth, his health had been deteriorating rapidly. He was becoming very listless, malnourished, and the whole family had lost all hope of the baby's survival. Diagnosis early and effective management resulted in the baby being discharged after 15 days of hospitalisation with an improvement in clinical condition and increase in weight of the baby...
October 2013: Journal of the Indian Medical Association
Seema Kapoor, Swati Bhayana, Ankur Singh, Jugal Kishore
OBJECTIVE: To study factors leading to mortality or hospitalization in children with Down syndrome and its effect on the quality of life of their parents. METHODS: The study was retrospective questionnaire based study conducted over 2 mo period at a genetic outpatient setting of a teaching medical college hospital. Seventy children with suggestive phenotype and confirmed Trisomy 21 on karyotyping were included. An essential criterion was a reasonable understanding of the language to construct history...
December 2014: Indian Journal of Pediatrics
Edwin A Mitchell, Tadd Clayton, Luis García-Marcos, Neil Pearce, Sunia Foliaki, Gary Wong
BACKGROUND: The association between birthweight and asthma, eczema and rhinoconjunctivitisis conflicting. AIMS: To examine the association between birthweight and symptoms of asthma, eczema and rhinoconjunctivitis. METHODS: Parents or guardians of children aged 6–7 yr completed written questionnaires about symptoms of asthma, rhinoconjunctivitis and eczema, and several risk factors, including birthweight. RESULTS: There were 162,324 children from 60 centres in 26 countries...
May 2014: Pediatric Allergy and Immunology
Joanna Murray, Sonia Saxena, Mike Sharland
In most high-income countries palivizumab prophylaxis is considered safe, efficacious and cost-effective for preventing respiratory syncytial virus (RSV) hospital admissions among specific subgroups of infants born preterm, with chronic lung disease or with congenital heart disease. Virtually all babies acquire RSV during infancy and previously healthy babies are not eligible to receive palivizumab. Emerging evidence suggests some benefit of palivizumab use in reducing recurrent wheeze among infants born preterm...
May 2014: Archives of Disease in Childhood
Andrea von Berg
Allergen exposure in the early postnatal life of an infant with a genetic predisposition for allergy is regarded as at least one essential risk factor for later development of allergic diseases. The most important allergen exposure in early life derives from the early nutrition of the baby. Thus, intervention based on the concept of reducing the allergen load in the diet is one approach for primary allergy prevention in children at risk. This includes breastfeeding, allergen-reduced diet of the pregnant and lactating mother, cow milk protein hydrolysate infant formulas (= hypoallergenic infant formula or HA formulas) and time of introduction of complementary food...
2013: World Review of Nutrition and Dietetics
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