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https://www.readbyqxmd.com/read/29677375/characteristics-of-retinal-structural-and-microvascular-alterations-in-early-type-2-diabetic-patients
#1
Qi Chen, Fan Tan, Yufei Wu, Xiran Zhuang, Chaoming Wu, Yuheng Zhou, Yingzi Li, Dan Cheng, Jianhua Wang, Fan Lu, Meixiao Shen
Purpose: To investigate early retinal structural and microvascular changes in patients with type 2 diabetes mellitus (DM) and to analyze relationships among the retinal structure, microvasculature, and choroid. Methods: Seventy-seven patients with type 2 DM (40 with no diabetic retinopathy [DR], 37 with nonproliferative diabetic retinopathy [NPDR]), and 34 control subjects were enrolled. Spectral-domain optical coherence tomography, operating in radial 18-line mode, obtained macular images of the eight intraretinal layers and the choroid...
April 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29670505/selective-fiber-degeneration-in-the-peripheral-nerve-of-a-patient-with-severe-complex-regional-pain-syndrome
#2
Adrien Yvon, Alessandro Faroni, Adam J Reid, Vivien C Lees
Aims: Complex regional pain syndrome (CRPS) is characterized by chronic debilitating pain disproportional to the inciting event and accompanied by motor, sensory, and autonomic disturbances. The pathophysiology of CRPS remains elusive. An exceptional case of severe CRPS leading to forearm amputation provided the opportunity to examine nerve histopathological features of the peripheral nerves. Methods: A 35-year-old female developed CRPS secondary to low voltage electrical injury. The CRPS was refractory to medical therapy and led to functional loss of the forelimb, repeated cutaneous wound infections leading to hospitalization...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29669450/innervation-of-the-interphalangeal-joint-of-the-thumb-anatomical-study
#3
Ezequiel E Zaidenberg, Dante Palumbo, Ezequiel Martinez, Martin Pastrana, Efrain Farias Cisneros, Carlos R Zaidenberg
We dissected 30 cadaveric thumb interphalangeal joints to delineate the sensory nerve anatomy of its capsule. Four articular branches supplying the interphalangeal joint capsule of the thumb were found in all specimens. Ulnar and radial proper digital nerves provide one palmar capsular nerve branch on their respective sides. Of the two dorsal branches of the radial nerve at the dorsum of the thumb, we observed that each nerve provided one branch to the interphalangeal dorsal capsule. Our findings demonstrate a consistent pattern of innervation and may provide the anatomical basis to the treating surgeon for an effective and safe denervation of the interphalangeal joint of the thumb...
January 1, 2018: Journal of Hand Surgery, European Volume
https://www.readbyqxmd.com/read/29667164/exploring-the-sea-urchin-neuropeptide-landscape-by-mass-spectrometry
#4
Eric B Monroe, Suresh P Annangudi, Andinet A Wadhams, Timothy A Richmond, Ning Yang, Bruce R Southey, Elena V Romanova, Liliane Schoofs, Geert Baggerman, Jonathan V Sweedler
Neuropeptides are essential cell-to-cell signaling messengers and serve important regulatory roles in animals. Although remarkable progress has been made in peptide identification across the Metazoa, for some phyla such as Echinodermata, limited neuropeptides are known and even fewer have been verified on the protein level. We employed peptidomic approaches using bioinformatics and mass spectrometry (MS) to experimentally confirm 23 prohormones and to characterize a new prohormone in nervous system tissue from Strongylocentrotus purpuratus, the purple sea urchin...
April 17, 2018: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/29666777/injury-of-the-radial-nerve-in-the-arm-a-review
#5
REVIEW
Taroob J Latef, Muhammad Bilal, Marc Vetter, Joe Iwanaga, Rod J Oskouian, R Shane Tubbs
Compression of the radial nerve is most commonly described at the supinator muscle (i.e., arcade of Frohse). However, radial nerve compression can occur in the arm. Therefore, the purpose of this article is to review both etiologies of radial nerve entrapment and the sites at which this can occur in the arm. The clinical presentation of radial nerve entrapment in the arm and how it differs from that of entrapment at other sites is reviewed and the conditions potentially predisposing to nerve entrapment are described...
February 16, 2018: Curēus
https://www.readbyqxmd.com/read/29663708/the-postmigratory-alar-topography-of-visceral-cranial-nerve-efferents-challenges-the-classical-model-of-hindbrain-columns
#6
Luis Puelles, Petr Tvrdik, Margaret Martínez-de-la-Torre
The classic columnar model of cranial nerve central representation assumes that all motor and sensory hindbrain neurons develop within four radial migration domains, held to be separated by a sulcal alar-basal boundary (sulcus limitans). This essay reviews a number of developmental data that challenge these concepts. These results are interpreted within the framework of present day neuromeric conception of the brainstem (the prosomeric model). Advances in dorsoventral patterning of the spinal cord and hindbrain now show that there exist up to eight alar microzones and five basal microzones (molecularly and histogenetically distinct longitudinal progenitor domains)...
April 16, 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29662112/optical-coherence-tomography-angiography-vessel-density-changes-after-acute-intraocular-pressure-elevation
#7
Qi Zhang, Jost B Jonas, Qian Wang, Szy Yann Chan, Liang Xu, Wen Bin Wei, Ya Xing Wang
To investigate changes in retinal vessel density in optic nerve head (ONH) and macula after acute intraocular pressure (IOP) elevation, we conducted a prospective observational study. Eyes with IOP rise ≥5 mmHg after 2-hour dark room prone provocative test (DRPPT) were included. Vasculature of ONH and macula was examined by optical coherence tomography angiography (OCTA) at baseline and after DRPPT. Among the 65 eyes of 42 individuals, 40 eyes with qualified images were enrolled. Mean IOP rise was 9.6 ± 4...
April 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29659600/reconstruction-of-a-10-mm-long-median-nerve-gap-in-an-ischemic-environment-using-autologous-conduits-with-different-patterns-of-blood-supply-a-comparative-study-in-the-rat
#8
Diogo Casal, Eduarda Mota-Silva, Inês Iria, Sara Alves, Ana Farinho, Cláudia Pen, Nuno Lourenço-Silva, Luís Mascarenhas-Lemos, José Silva-Ferreira, Mário Ferraz-Oliveira, Valentina Vassilenko, Paula Alexandra Videira, João Goyri-O'Neill, Diogo Pais
The aim of this study was to evaluate in the Wistar rat the efficacy of various autologous nerve conduits with various forms of blood supply in reconstructing a 10-mm-long gap in the median nerve (MN) under conditions of local ischemia. A 10-mm-long median nerve defect was created in the right arm. A loose silicone tube was placed around the nerve gap zone, in order to simulate a local ischemic environment. Rats were divided in the following experimental groups (each with 20 rats): the nerve Graft (NG) group, in which the excised MN segment was reattached; the conventional nerve flap (CNF) and the arterialized neurovenous flap (ANVF) groups in which the gap was bridged with homonymous median nerve flaps; the prefabricated nerve flap (PNF) group in which the gap was reconstructed with a fabricated flap created by leaving an arteriovenous fistula in contact with the sciatic nerve for 5 weeks; and the two control groups, Sham and Excision groups...
2018: PloS One
https://www.readbyqxmd.com/read/29650376/trapezius-muscle-transfer-for-restoration-of-elbow-extension-in-a-traumatic-brachial-plexus-injury
#9
Hamza M Alrabai, Martin G Gesheff, Ahmed I Hammouda, Janet D Conway
Voluntary elbow extension is essential for optimal upper limb positioning required for daily living activities, particularly above-shoulder maneuvers. The authors present a case of traumatic brachial plexus injury in which paralysis of the musculature selectively supplied by the posterior cord was based on magnetic resonance imaging and nerve conduction studies. An attempt at a radial nerve graft at another center was not effective. Ipsilateral hand function improved after multiple local tendon transfers were performed...
April 9, 2018: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29644964/ulnar-and-superficial-radial-nerve-swellings-in-two-patients-with-leprosy
#10
Neeraj Kumar, Ravindra Kumar Garg, Hardeep Singh Malhotra
No abstract text is available yet for this article.
April 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29644301/pseudoaneurysm-of-brachial-artery-a-rare-cause-of-median-nerve-compression
#11
João Lobo, Mariana Cunha Ferreira, Pedro Negrão Ramos
Background: The authors present an unusual clinical case of high median nerve compression caused by an iatrogenic pseudoaneurysm of the brachial artery after an angiography with a follow up of 9 months. Methods: A 73-year-old male was seen with progressive numbness, loss of opponency and diminution of strength of finger flexion in the left hand after an angiography with direct puncture of the left humeral artery. Physical examination revealed a hard consistency internal distal arm swelling with the size of a walnut, non-pulsatile and with a Tinel sign on percussion...
April 2018: Trauma Case Reports
https://www.readbyqxmd.com/read/29644112/unusual-bilateral-sensory-innervation-of-the-dorsum-of-hand-by-lateral-antebrachial-cutaneous-nerve-a-case-report
#12
Neha, Hare Krishna
A 68-year-old male cadaver showed bilateral variation in the sensory innervation of the dorsum of hand. On the dorsum of right hand, first digit and lateral half of second digit were supplied by lateral antebrachial cutaneous nerve (LABCN); medial side of second digit and lateral side of third digit were supplied by superficial branch of radial nerve (SBRN) and medial side of third digit, the fourth and fifth digits were supplied by dorsal cutaneous branch of ulnar nerve (DBUN). On the dorsum of the left hand, lateral side of first digit was supplied by LABCN, medial side of first digit, the second and third digits as well as the lateral side of fourth digit were supplied by SBRN; medial side of fourth digit and fifth digit were supplied by DBUN...
March 2018: Anatomy & Cell Biology
https://www.readbyqxmd.com/read/29642947/absence-of-flexor-carpi-radialis-identified-during-volar-approach-for-fixation-of-distal-radius-fracture-a-case-report
#13
Tomoyo Irie, Makoto Motomiya, Norimasa Iwasaki
BACKGROUND: Volar locking plate fixation of distal radius fractures is commonly performed because of its good clinical outcomes. The flexor carpi radialis (FCR) approach is one of the most popular approaches to dissecting the volar side of the distal radius because of its simplicity and safety. We describe an extremely rare case of an absent FCR identified during a volar approach for fixation of a distal radius fracture. CASE PRESENTATION: A 59-year-old woman with distal radius fracture underwent surgery using the usual FCR approach and volar locking plate...
April 11, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29628712/best-care-paradigm-to-optimize-functionality-after-extra-articular-distal-humeral-fractures-in-the-young-patient
#14
REVIEW
Mark S Ayoub, Ivan S Tarkin
For younger patients with extra-articular distal humerus fractures closed management is plagued with high rates of malunion, suboptimal functional outcomes, extended immobilization with loss of early motion, a delay in return to work, and a general period of lost productivity. Surgical management offers an appealing alternative. Maintaining respect for the triceps musculature and minimizing iatrogenic injury to the radial nerve are primary concerns with operative treatment. Accordingly, use of a triceps-sparing approach and single column plating may be the optimal treatment paradigm in the young patient presenting with an extra-articular distal humerus fracture...
March 2018: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/29627590/exploring-experimental-autoimmune-optic-neuritis-using-multimodal-imaging
#15
Praveena Manogaran, Christine Walker-Egger, Marijana Samardzija, Conny Waschkies, Christian Grimm, Markus Rudin, Sven Schippling
BACKGROUND: Neuro-axonal injury is a key contributor to non-reversible long-term disability in multiple sclerosis (MS). However, the underlying mechanisms are not yet fully understood. Visual impairment is common among MS patients, in which episodes of optic neuritis (ON) are often followed by structural retinal damage and sustained functional impairment. Alterations in the optic nerve and retina have also been described in rodent experimental autoimmune encephalomyelitis (EAE), a model of MS...
April 5, 2018: NeuroImage
https://www.readbyqxmd.com/read/29625454/white-matter-abnormalities-and-correlation-with-severity-in-normal-tension-glaucoma-a-whole-brain-atlas-based-diffusion-tensor-study
#16
Rong Wang, Zuohua Tang, Xinghuai Sun, Lingjie Wu, Jie Wang, Yufeng Zhong, Zebin Xiao
Purpose: To detect injury of whole brain white matter (WM) in normal tension glaucoma (NTG) patients by using diffusion tensor imaging (DTI) and to analyze the correlations between DTI parameters and glaucoma indices. Methods: Twenty mild, 17 moderate, and 18 severe NTG patients as well as 25 normal subjects were enrolled in this study. Atlas-based diffusion tensor analysis was performed to measure the fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD)...
March 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29625342/phantom-somatosensory-evoked-potentials-following-selective-intraneural-electrical-stimulation-in-two-amputees
#17
Giuseppe Granata, Riccardo Di Iorio, Roberto Romanello, Francesco Iodice, Stanisa Raspopovic, Francesco Petrini, Ivo Strauss, Giacomo Valle, Thomas Stieglitz, Paul Čvančara, David Andreu, Jean-Louis Divoux, David Giraud, Loic Wauters, Arthur Hiairrassary, Winnie Jensen, Silvestro Micera, Paolo Maria Rossini
OBJECTIVE: The aim of the paper is to objectively demonstrate that amputees implanted with intraneural interfaces are truly able to feel a sensation in the phantom hand by recording "phantom" somatosensory evoked potentials from the corresponding brain areas. METHODS: We implanted four transverse intrafascicular multichannel electrodes, available with percutaneous connections to a multichannel electrical stimulator, in the median and ulnar nerves of two left trans-radial amputees...
March 26, 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29619502/safe-zone-for-the-posterior-interosseous-nerve-with-regard-to-the-lateral-and-posterior-approaches-to-the-proximal-radius
#18
Gloria Maria Hohenberger, Angelika Maria Schwarz, Marco Johannes Maier, Peter Grechenig, Jan Dauwe, Christoph Grechenig, Renate Krassnig, Axel Gänsslen, Andreas Heinrich Weiglein
PURPOSE: The posterior interosseous nerve (PIN) is at risk during the posterior and lateral approaches to the proximal radius. We aimed to define a safe zone for these approaches to avoid injury of the PIN and to evaluate their close and changing relationship to the nerve during forearm rotation. METHODS: The study collective consisted of 50 upper limbs. After performance of the lateral approach, the distance between the tip of the radial head and the PIN's exit point from the supinator (= distance 1) and the shortest interval between the nerve's exit to the radial margin of the ulna (= distance 2) were measured in maximum pronation and supination...
April 4, 2018: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/29611789/superficial-branch-of-the-radial-nerve-injury-a-case-for-conscious-perioperative-arterial-cannulation
#19
John Hickman, Ahmed Chekairi
We present a case of an injury to the superficial branch of the radial nerve following unconscious radial artery cannulation in a 57-year-old gentleman for revision of lumbar spinal fusion. Nerve damage is a rare complication of this commonly used technique; whilst usually self-limiting, it can lead to a significant under-reported burden of morbidity on our patients. We discuss current norms of practice, questioning the safety of unconscious arterial cannulation, and suggest that, where possible, it should be performed in the conscious patient to minimise the risk of this rare complication...
April 2018: Journal of Perioperative Practice
https://www.readbyqxmd.com/read/29605951/future-perspectives-in-the-management-of-nerve-injuries
#20
Susan E Mackinnon
AIM:  The author presents a solicited "white paper" outlining her perspective on the role of nerve transfers in the management of nerve injuries. METHODS:  PubMed/MEDLINE and EMBASE databases were evaluated to compare nerve graft and nerve transfer. An evaluation of the scientific literature by review of index articles was also performed to compare the number of overall clinical publications of nerve repair, nerve graft, and nerve transfer. Finally, a survey regarding the prevalence of nerve transfer surgery was administrated to the World Society of Reconstructive Microsurgery (WSRM) results...
April 1, 2018: Journal of Reconstructive Microsurgery
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