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https://www.readbyqxmd.com/read/28765218/dengue-virus-infected-dendritic-cells-but-not-monocytes-activate-natural-killer-cells-through-a-contact-dependent-mechanism-involving-adhesion-molecules
#1
Vivian Vasconcelos Costa, Weijian Ye, Qingfeng Chen, Mauro Martins Teixeira, Peter Preiser, Eng Eong Ooi, Jianzhu Chen
Natural killer (NK) cells play a protective role against dengue virus (DENV) infection, but the cellular and molecular mechanisms are not fully understood. Using an optimized humanized mouse model, we show that human NK cells, through the secretion of gamma interferon (IFN-γ), are critical in the early defense against DENV infection. Depletion of NK cells or neutralization of IFN-γ leads to increased viremia and more severe thrombocytopenia and liver damage in humanized mice. In vitro studies using autologous human NK cells show that DENV-infected monocyte-derived dendritic cells (MDDCs), but not monocytes, activate NK cells in a contact-dependent manner, resulting in upregulation of CD69 and CD25 and secretion of IFN-γ...
August 1, 2017: MBio
https://www.readbyqxmd.com/read/28756769/continuous-glucose-monitoring-in-the-icu-clinical-considerations-and-consensus
#2
REVIEW
James S Krinsley, J Geoffrey Chase, Jan Gunst, Johan Martensson, Marcus J Schultz, Fabio S Taccone, Jan Wernerman, Julien Bohe, Christophe De Block, Thomas Desaive, Pierre Kalfon, Jean-Charles Preiser
Glucose management in intensive care unit (ICU) patients has been a matter of debate for almost two decades. Compared to intermittent monitoring systems, continuous glucose monitoring (CGM) can offer benefit in the prevention of severe hyperglycemia and hypoglycemia by enabling insulin infusions to be adjusted more rapidly and potentially more accurately because trends in glucose concentrations can be more readily identified. Increasingly, it is apparent that a single glucose target/range may not be optimal for all patients at all times and, as with many other aspects of critical care patient management, a personalized approach to glucose control may be more appropriate...
July 31, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/28756470/a-critical-view-on-primary-and-secondary-outcome-measures-in-nutrition-trials
#3
EDITORIAL
Yaseen M Arabi, Jean-Charles Preiser
No abstract text is available yet for this article.
July 29, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/28737574/is-there-a-role-for-enterohormones-in-the-gastroparesis-of-critically-ill-patients
#4
Carlos A Santacruz, Amanda Quintairos, Claudia Righy, Ilaria A Crippa, Lucio Couto, Virginie Imbault, Mongkolpun Wasineeart, Mathieu De Ryckere, Jean-Charles Preiser
OBJECTIVES: Delayed gastric emptying occurs in critically ill patients and impairs the delivery, digestion, and absorption of enteral feeding. A pathophysiologic role of the enterohormones peptide YY and ghrelin is supported by preclinical data. To compare the circulating plasma levels of peptide YY and ghrelin in control subjects and in critically ill patients, during feeding and fasting, and to search for a correlation with gastric emptying. DESIGN: A prospective observational trial...
July 21, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28732085/point-of-care-screening-for-hepatitis-b-virus-infection-in-pregnant-women-at-an-antenatal-clinic-a-south-african-experience
#5
Nafiisah Chotun, Wolfgang Preiser, Christoffel Johannes van Rensburg, Pedro Fernandez, Gerhard Barnard Theron, Dieter Glebe, Monique Ingrid Andersson
BACKGROUND & AIMS: Elimination of HIV and syphilis mother-to-child transmission (MTCT) has received much attention but little consideration has been given to the possibility of elimination of HBV MTCT. In sub-Saharan Africa, HBV vertical transmission continues to be reported and it remains an important public health problem. This study aimed to assess the feasibility of screening pregnant women for HBV using a point-of-care (POC) test and implementing interventions to prevent HBV MTCT...
2017: PloS One
https://www.readbyqxmd.com/read/28683458/oral-nitrate-increases-microvascular-reactivity-and-the-number-of-visible-perfused-microvessels-in-healthy-volunteers
#6
Louis Kolb, Diego Orbegozo, Jacques Creteur, Jean-Charles Preiser, Jean-Louis Vincent, Daniel De Backer
Nitric oxide (NO) plays an important role in controlling microcirculatory function, but the effects of exogenous administration of nitrate (NO3-) on the microcirculation have not been well studied. We evaluated whether NO3- could influence the microvascular response to hypoxia in 17 healthy volunteers. We used a vascular occlusion test (VOT) to assess the response of near-infrared spectroscopy-derived indexes to hypoxic stress before and 2 h 15 min after oral administration of 800 mg potassium nitrate. We also monitored changes in the sublingual microcirculation using side-stream dark-field (SDF) video microscopy...
July 7, 2017: Journal of Vascular Research
https://www.readbyqxmd.com/read/28622798/singapore-malaria-network-meeting-singmalnet-2016
#7
EDITORIAL
Peter Preiser, Laurent Renia, Zbynek Bozdech, Kevin Tan, Bruce Russell, Brian M Cooke
No abstract text is available yet for this article.
June 2017: International Journal for Parasitology
https://www.readbyqxmd.com/read/28599676/a-randomized-trial-of-supplemental-parenteral-nutrition-in-underweight-and-overweight-critically-ill-patients-the-top-up-pilot-trial
#8
Paul E Wischmeyer, Michel Hasselmann, Christine Kummerlen, Rosemary Kozar, Demetrios James Kutsogiannis, Constantine J Karvellas, Beth Besecker, David K Evans, Jean-Charles Preiser, Leah Gramlich, Khursheed Jeejeebhoy, Rupinder Dhaliwal, Xuran Jiang, Andrew G Day, Daren K Heyland
BACKGROUND: Nutrition guidelines recommendations differ on the use of parenteral nutrition (PN), and existing clinical trial data are inconclusive. Our recent observational data show that amounts of energy/protein received early in the intensive care unit (ICU) affect patient mortality, particularly for inadequate nutrition intake in patients with body mass indices (BMIs) of <25 or >35. Thus, we hypothesized increased nutrition delivery via supplemental PN (SPN) + enteral nutrition (EN) to underweight and obese ICU patients would improve 60-day survival and quality of life (QoL) versus usual care (EN alone)...
June 9, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/28594576/provision-of-nutrients-to-the-acutely-ill-introducing-the-baby-stomach-concept
#9
Jean-Charles Preiser, Jan Wernerman
No abstract text is available yet for this article.
June 8, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28465193/clinical-outcomes-of-proximal-row-carpectomy-by-preoperative-midcarpal-joint-morphological-classification-viegas-type-i-versus-type-ii
#10
A Toffoli, H Lenoir, C Lazerges, B Coulet, M Chammas
The midcarpal joint can be classified into two anatomical types - Viegas type I and Viegas type II - based on the absence or presence of a medial facet for the hamate on the lunate (lunohamate facet). Type I is associated with a round capitate shape, which theoretically allows better congruence with the lunate fossa of the distal radius following proximal row carpectomy (PRC). This morphological feature has never been considered as a predictive factor of clinical outcome for this surgical procedure. This study aimed to compare the clinical and radiological outcomes of the two Viegas types following PRC...
June 2017: Hand Surgery and Rehabilitation
https://www.readbyqxmd.com/read/28409866/p-falciparum-rh5-basigin-interaction-induces-changes-in-the-cytoskeleton-of-the-host-rbc
#11
Yaw Aniweh, Xiaohong Gao, Piliang Hao, Wei Meng, Soak Kuan Lai, Karthigayan Gunalan, Trang T Chu, Ameya Sinha, Julien Lescar, Rajesh Chandramohanadas, Hoi Yeung Li, Siu Kwan Sze, Peter R Preiser
The successful invasion of Plasmodium is an essential step in their life cycle. The parasite reticulocyte-binding protein homologues (RHs) and erythrocyte-binding like proteins are two families involved in the invasion leading to merozoite-red blood cell (RBC) junction formation. Ca(2+) signaling has been shown to play a critical role in the invasion. RHs have been linked to Ca(2+) signaling, which triggers the erythrocyte-binding like proteins release ahead of junction formation, consistent with RHs performing an initial sensing function in identifying suitable RBCs...
April 13, 2017: Cellular Microbiology
https://www.readbyqxmd.com/read/28374096/the-intensive-care-medicine-research-agenda-in-nutrition-and-metabolism
#12
REVIEW
Yaseen M Arabi, Michael P Casaer, Marianne Chapman, Daren K Heyland, Carole Ichai, Paul E Marik, Robert G Martindale, Stephen A McClave, Jean-Charles Preiser, Jean Reignier, Todd W Rice, Greet Van den Berghe, Arthur R H van Zanten, Peter J M Weijs
PURPOSE: The objectives of this review are to summarize the current practices and major recent advances in critical care nutrition and metabolism, review common beliefs that have been contradicted by recent trials, highlight key remaining areas of uncertainty, and suggest recommendations for the top 10 studies/trials to be done in the next 10 years. METHODS: Recent literature was reviewed and developments and knowledge gaps were summarized. The panel identified candidate topics for future trials in critical care nutrition and metabolism...
April 3, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/28357965/racial-differences-in-seroprevalence-of-hav-and-hev-in-blood-donors-in-the-western-cape-south-africa-a-clue-to-the-predominant-hev-genotype
#13
T Lopes, R Cable, C Pistorius, T Maponga, S Ijaz, W Preiser, R Tedder, M I Andersson
Hepatitis E virus (HEV) infection is a major cause of acute hepatitis worldwide. This infection causes major water-borne outbreaks in low- and middle-income countries, whilst in industrialised countries this infection is zoonotic. These differences in epidemiology are related to different HEV genotypes. HEV genotype 3 is a zoonotic infection, whilst genotype 2 causes large outbreaks. This study determined the seroprevalence of HEV in blood donors from the Western Cape. Anti-hepatitis A virus (anti-HAV) antibody was detected in 184/300 (61%) donors...
July 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28350508/role-of-nutrition-support-in-inflammatory-conditions
#14
Olivier Lheureux, Jean-Charles Preiser
This review intends to summarize recent development on the potential nutrition implications of acute inflammation encountered during critical illness. Different aspects of the inflammatory response and their impact on nutrition management during critical illness will be discussed: the timing of the postinjury metabolic response, the integration of regulatory mechanisms involved in the metabolic response to stress, the oxidative stress, the metabolic and clinical consequences in terms of energy expenditure, use of energy, changes in body composition, and behavior...
March 1, 2017: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/28332579/corrigendum-towards-ultrasensitive-malaria-diagnosis-using-surface-enhanced-raman-spectroscopy
#15
Keren Chen, Clement Yuen, Yaw Aniweh, Peter Preiser, Quan Liu
No abstract text is available yet for this article.
March 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28268395/context-aware-fall-detection-using-inertial-sensors-and-time-of-flight-transceivers
#16
Mahesh C Shastry, Meysam Asgari, Eric A Wan, Joseph Leitschuh, Nicholas Preiser, Jon Folsom, John Condon, Michelle Cameron, Peter G Jacobs
Automatic detection of falls is important for enabling people who are older to safely live independently longer within their homes. Current automated fall detection systems are typically designed using inertial sensors positioned on the body that generate an alert if there is an abrupt change in motion. These inertial sensors provide no information about the context of the person being monitored and are prone to false positives that can limit their ongoing usage. We describe a fall-detection system consisting of a wearable inertial measurement unit (IMU) and an RF time-of-flight (ToF) transceiver that ranges with other ToF beacons positioned throughout a home...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226562/context-aware-fall-detection-using-inertial-sensors-and-time-of-flight-transceivers
#17
Mahesh C Shastry, Meysam Asgari, Eric A Wan, Joseph Leitschuh, Nicholas Preiser, Jon Folsom, John Condon, Michelle Cameron, Peter G Jacobs, Mahesh C Shastry, Meysam Asgari, Eric A Wan, Joseph Leitschuh, Nicholas Preiser, Jon Folsom, John Condon, Michelle Cameron, Peter G Jacobs, Michelle Cameron, Jon Folsom, Meysam Asgari, John Condon, Nicholas Preiser, Joseph Leitschuh, Peter G Jacobs, Mahesh C Shastry, Eric A Wan
Automatic detection of falls is important for enabling people who are older to safely live independently longer within their homes. Current automated fall detection systems are typically designed using inertial sensors positioned on the body that generate an alert if there is an abrupt change in motion. These inertial sensors provide no information about the context of the person being monitored and are prone to false positives that can limit their ongoing usage. We describe a fall-detection system consisting of a wearable inertial measurement unit (IMU) and an RF time-of-flight (ToF) transceiver that ranges with other ToF beacons positioned throughout a home...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28173874/could-type-2-diabetes-be-a-component-of-the-post-intensive-care-syndrome
#18
EDITORIAL
Jean-Charles Preiser, Caroline de Longueville
No abstract text is available yet for this article.
February 8, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/28168570/early-enteral-nutrition-in-critically-ill-patients-esicm-clinical-practice-guidelines
#19
REVIEW
Annika Reintam Blaser, Joel Starkopf, Waleed Alhazzani, Mette M Berger, Michael P Casaer, Adam M Deane, Sonja Fruhwald, Michael Hiesmayr, Carole Ichai, Stephan M Jakob, Cecilia I Loudet, Manu L N G Malbrain, Juan C Montejo González, Catherine Paugam-Burtz, Martijn Poeze, Jean-Charles Preiser, Pierre Singer, Arthur R H van Zanten, Jan De Waele, Julia Wendon, Jan Wernerman, Tony Whitehouse, Alexander Wilmer, Heleen M Oudemans-van Straaten
PURPOSE: To provide evidence-based guidelines for early enteral nutrition (EEN) during critical illness. METHODS: We aimed to compare EEN vs. early parenteral nutrition (PN) and vs. delayed EN. We defined "early" EN as EN started within 48 h independent of type or amount. We listed, a priori, conditions in which EN is often delayed, and performed systematic reviews in 24 such subtopics. If sufficient evidence was available, we performed meta-analyses; if not, we qualitatively summarized the evidence and based our recommendations on expert opinion...
March 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/28130686/sepsis-frontiers-in-supportive-care-organisation-and-research
#20
REVIEW
Anders Perner, Andrew Rhodes, Bala Venkatesh, Derek C Angus, Ignacio Martin-Loeches, Jean-Charles Preiser, Jean-Louis Vincent, John Marshall, Konrad Reinhart, Michael Joannidis, Steven M Opal
Because of its high incidence and clinical complexity, sepsis is a major challenge to clinicians and researchers and a global burden to healthcare systems and society. Despite recent progress, short- and long-term morbidity, mortality and costs remain high in both developed and developing countries. Thus, further improvements in supportive interventions and organisation of care are likely to have a substantial impact upon global health. In this narrative review, invited experts describe the challenges and progress to be made in sepsis research and care in the near future...
April 2017: Intensive Care Medicine
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