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https://www.readbyqxmd.com/read/28100473/delineating-the-phenotypic-spectrum-of-bainbridge-ropers-syndrome-12-new-patients-with-de-novo-heterozygous-loss-of-function-mutations-in-asxl3-and-review-of-published-literature
#1
M Balasubramanian, J Willoughby, A E Fry, A Weber, H V Firth, C Deshpande, J N Berg, K Chandler, K A Metcalfe, W Lam, D Pilz, S Tomkins
BACKGROUND: Bainbridge-Ropers syndrome (BRPS) is a recently described developmental disorder caused by de novo truncating mutations in the additional sex combs like 3 (ASXL3) gene. To date, there have been fewer than 10 reported patients. OBJECTIVES: Here, we delineate the BRPS phenotype further by describing a series of 12 previously unreported patients identified by the Deciphering Developmental Disorders study. METHODS: Trio-based exome sequencing was performed on all 12 patients included in this study, which found a de novo truncating mutation in ASXL3...
January 18, 2017: Journal of Medical Genetics
https://www.readbyqxmd.com/read/28099360/aggressive-intramuscular-hemangiomas-in-the-upper-extremity-a-case-report
#2
Hui Lu, Qiang Chen, Hu Yang, Hui Shen
INTRODUCTION: Intramuscular hemangioma (IMH) is a rare congenital soft tissue tumor. Here, we report a case of IMH patient who had undergone several surgeries and other treatments that were all ineffective before he visited us. CLINICAL FINDINGS: This IMH patient was a 16-yearold male who was born with a tumor of unknown size in his right hand and forearm. On physical examination, the tumor and skin flap complex was seen with a size of 14 cm_12 cm in his right hand, and the multiple postoperative scars were shown on his right hand and forearm...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28099162/thermography-based-blood-flow-imaging-in-human-skin-of-the-hands-and-feet-a-spectral-filtering-approach
#3
A A Sagaidachnyi, A V Fomin, D A Usanov, A V Skripal
The determination of the relationship between skin blood flow and skin temperature dynamics is the main problem in thermography-based blood flow imaging. Oscillations in skin blood flow are the source of thermal waves propagating from micro-vessels toward the skin's surface, as assumed in this study. This hypothesis allows us to use equations for the attenuation and dispersion of thermal waves for converting the temperature signal into the blood flow signal, and vice versa. We developed a spectral filtering approach (SFA), which is a new technique for thermography-based blood flow imaging...
January 18, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/28062432/epirubicin-extravasation-consequences-of-delayed-management
#4
Olivia Hale, Peter George Deutsch, Anindya Lahiri
Epirubicin is an anthracycline chemotherapy agent used for treatment of several cancers including oesophageal, breast and gastric. Extravasation is a well-recognised and serious complication of any intravenous therapies but especially chemotherapeutic agents. Signs of the injury can be subtle and without prompt recognition and treatment there can be extensive tissue damage and depending on location of injury this can result in significant functional loss. In this article, a case of delayed management of epirubicin extravasation from a cannula situated at the dorsum of the hand is discussed...
January 6, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28053377/feasibility-of-type-iii-venous-flap-in-coverage-of-hand-defects-following-trauma-and-burns
#5
Pawan Agarwal, Ambuj Kumar, Dhananjaya Sharma
INTRODUCTION: venous flaps are alternative reconstructive option for coverage of defects. They are nourished by venous blood flow or by arterial blood flowing through the venous network. This study was conducted to assess the feasibility of venous flap in coverage of extremities defects following trauma and burns. MATERIAL AND METHODS: Over a period of one year, 15 arterialized venous flaps were applied to skin defects of the hand. Postoperatively flap were monitored for survival and patients followed up for three months...
October 2016: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/28045826/free-hand-perforator-concept-in-osteocutaneous-free-fibula-flap-through-posterior-approach
#6
Yigit Ozer Tiftikcioglu, Ersin Gur, Tahir Gurler
BACKGROUND: The fibula flap is a workhorse flap for bony reconstruction of oro-mandibular area and can be modified to include soft tissue for reconstruction of composite defects. However, the design of a reliable skin paddle that can be used for composite tissue reconstruction remains a challenge. The authors described the applicability of perforator concept for a more reliable free osteomusculocutaneous fibula flap. METHODS: Between 2013 and 2015, 29 patients underwent free fibula osteocutaneous flap reconstruction...
December 30, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28039499/omega-%C3%AE-advancement-flap-a-circular-flap-design-for-the-aesthetic-closure-of-circular-skin-defect
#7
Enver Arpaci, Serdar Altun, Nilgün Markal Ertas, Ahmet Cagri Uysal, Emre Inozu
BACKGROUND: Most skin defects that require reconstruction with a local skin flap have a circular- or oval-shaped pattern. The majority of the skin flaps are planned in an angled shape. Therefore, it may be necessary to modify the shape of the defect or the distal flap border to minimize tissue distortion. We have designed a circular-shaped advancement flap to be compatible with the circular defect. METHODS: Eighteen cases of reconstruction of skin defects in the face, chest wall, hand and buttock area were performed using the omega advancement flap between 2010 and 2014...
December 30, 2016: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28033231/anterior-lens-capsule-in-the-management-of-chronic-full-thickness-macular-hole
#8
Juan B Yepez, Felipe A Murati, Jazmin De Yepez, Michele Petitto, J Fernando Arevalo
PURPOSE: To report the use of anterior lens capsule flap transplantation in two cases with chronic full-thickness macular hole (MH). METHODS: Case series. RESULTS: Two cases of chronic MH with a new treatment approach were reported. In the first case, a 66-year-old man presented with a chronic idiopathic MH in the left eye for 2 years. Presenting visual acuity was hand motion. The patient underwent phacoemulsification and vitrectomy with anterior lens capsule flap transplantation in the MH...
December 28, 2016: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28026846/vascular-anatomy-of-the-thenar-eminence-its-relevance-to-a-pedicled-or-free-thenar-flap
#9
Ana Zekavica, Milan Milisavljević, Dražan Erić, Branislava Ćurčić, Sunčica Popović, Biljana Vitošević, Aleksandra Dožić, Bojan Štimec, Radovan Manojlović
BACKGROUND: The aim of this study was to clarify the arterial supply of the skin covering the prominent part of the thenar eminence in order to describe the possibility and potential for harvesting a pedicled or a free flap from the thenar eminence. MATERIALS AND METHODS: The arteries were studied in 30 post-mortem specimens of human hands; 3 previously perfused with 4% formaldehyde solution, and injected with black India ink, and 27 injected with methyl-methacrylate and afterwards corroded in 40% potassium hydroxide solution...
December 27, 2016: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/28005165/free-lateral-tarsal-artery-perforator-flap-with-functioning-extensor-digitorum-brevis-muscle-for-thenar-reconstruction-a-case-report
#10
Tianliang Wang, Subhash Regmi, Hongjun Liu, Junbo Pan, Ruixing Hou
In this case report, we describe reconstructive surgery in one patient using a free lateral tarsal artery perforator flap with a functioning extensor digitorum brevis muscle. A 47-year-old woman sustained a crush-avulsion injury to her dominant right hand while working in a factory. A large thenar skin and muscle defect (5.5 cm × 4.0 cm) occurred as a consequence of surgical debridement. The skin and muscle defect was repaired using a free lateral tarsal artery perforator flap with a functioning extensor digitorum brevis muscle in a single operation...
December 22, 2016: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28002194/spontaneous-dislocation-of-trabeculectomy-scleral-flap-in-the-anterior-chamber-in-a-patient-with-pseudoxanthoma-elasticum
#11
Lina Danieliute, Myrto Tsagkataki, Eleni Nikita
We report a case of a 54-year-old man, known to have pseudoxanthoma elasticum (PXE), who had a trabeculectomy in his left eye for secondary glaucoma following blunt trauma. Ten years after augmented trabeculectomy, the patient presented to casualty clinic with an inferiorly dislocated, anterior chamber (AC), scleral trabeculectomy flap. Corrected vision was hand movement with an intraocular pressure of 17 mm Hg. There was significant AC inflammation (cells 2+). Gonioscopy revealed a residual mobile scleral flap...
December 20, 2016: Journal of Glaucoma
https://www.readbyqxmd.com/read/27958214/the-correct-shake-for-handshake-in-glued-intrascleral-fixation-of-intraocular-lens
#12
Priya Narang, Amar Agarwal
We hereby describe the correct method to perform a "handshake technique" and easy transfer of haptics from one hand to another for glued intrascleral fixation of an intraocular lens (glued IOL). The procedure was implemented in 57 cases that necessitated the application of performing a glued IOL procedure and it resulted in an appropriate and easy externalization of haptic in all the cases. The surgeons' positioning with reference to the scleral flap is an essential component and the surgeon should always be positioned perpendicular to the plane of scleral flaps and the plane of haptic maneuver...
November 2016: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/27940039/management-strategy-for-congenital-thumb-differences-in-paediatric-patients
#13
REVIEW
G Dautel
Congenital thumb anomalies are common and have a major impact given the specific functional role of the thumb. They may occur alone or as part of a multiple congenital anomaly syndrome. The primary goal of surgical management is to improve or restore pincer grip. In patients with 'congenital' trigger thumb, the A1 pulley must be released if the interphalangeal joint remains in fixed flexion. Thumb duplication is generally managed by reconstruction of the thumb from the predominant (ulnar-based) digit; the accessory (radial-based) digit is excised after collection of its tissue components needed for the reconstruction programme...
December 8, 2016: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/27896187/fascial-free-flap-for-reconstruction-of-the-dorsolateral-hand-and-digits-the-advantage-of-a-thin-contour
#14
Min Gue Lee, Jin Soo Kim, Dong Chul Lee, Si Young Roh, Kyung Jin Lee, Byeong Kyoo Choi
BACKGROUND: Fascial free flaps have been widely used for reconstruction of the hand because they are thin. However, studies reporting objective data regarding the advantages of this approach are lacking. Thus, we report our experience with such flaps. METHODS: Forty-five cases of fascial free flaps between November 2006 and March 2014 were reviewed. Nine cases involving reconstructed dorsal or lateral defects were included. Four anterolateral thigh fascial free flaps and 5 lateral arm fascial free flaps were examined...
November 2016: Archives of Plastic Surgery
https://www.readbyqxmd.com/read/27896147/early-debridement-and-delayed-primary-vascularized-cover-in-forearm-electrical-burns-a-prospective-study
#15
Aniruddh Mene, Gautam Biswas, Atul Parashar, Anish Bhattacharya
AIM: To look into the management options of early debridement of the wound, followed by vascularized cover to bring in fresh blood supply to remaining tissue in electrical burns. METHODS: A total of 16 consecutive patients sustaining full thickness forearm burns over a period of one year were included in the study group. Debridement was undertaken within 48 h in 13 patients. Three patients were taken for debridement after 48 h. Debridement was repeated within 2-4 d after daily wound assessment and need for further debridement...
November 4, 2016: World Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/27895538/syndactyly-release
#16
REVIEW
Tara L Braun, Jeffrey G Trost, William C Pederson
Syndactyly is one of the most common congenital hand anomalies treated by pediatric plastic surgeons. Established principles of syndactyly separation dictate the timing and order of syndactyly release, with the goals of surgery being the creation of an anatomically normal webspace, tension-free closure of soft tissue, and return of function to the fingers. Numerous surgical methods have been described, many of which involve the use of local flaps to reconstruct the commissure and full-thickness skin grafts for coverage of raw areas...
November 2016: Seminars in Plastic Surgery
https://www.readbyqxmd.com/read/27894579/future-perspectives-of-pre-expanded-perforator-flaps
#17
REVIEW
Lee L Q Pu, Chunmei Wang
Although clinical application of a pre-expanded perforator flap is primarily focused on face and neck reconstructions, such a flap has also been used to reconstruct defects in the trunk, extremities, or hands. With better understanding of the improved blood supply to the flap and the mechanism on the prefabrication of blood supply within the flap, the pre-expanded perforator flap will definitely play a more important role in reconstructive surgery and can be used in selected patients by many plastic surgeons worldwide with good reconstructive and cosmetic outcomes...
January 2017: Clinics in Plastic Surgery
https://www.readbyqxmd.com/read/27894578/pre-expanded-and-prefabricated-abdominal-superthin-skin-perforator-flap-for-total-hand-resurfacing
#18
REVIEW
Chunmei Wang, Junyi Zhang, Sifen Yang, Ping Song, Lun Yang, Lee L Q Pu
Reconstruction of the postburn hand remains a challenge for surgeons. For cosmetic and functional requirements, the desired flap should be thin enough to ensure the flexibility of the hand. Conventional perforator flaps serve as a viable option when reconstructing the postburn hand to regain functionality. However, limitations include the discrepancy in tissue thickness and the difficulty with donor site closure. Thus, a preexpanded superthin skin perforator flap is an ideal choice for postburn hand reconstruction, with the trade-off being a longer treatment course (3-4 months), but with results that satisfy both patients and their surgeons...
January 2017: Clinics in Plastic Surgery
https://www.readbyqxmd.com/read/27884200/a-three-stage-procedure-using-bone-transportation-for-the-treatment-of-sternoclavicular-infectious-arthritis
#19
Hua Chen, Xinran Ji, Ming Hao, Qun Zhang, Peifu Tang
BACKGROUND: Sternoclavicular joint (SCJ) infectious arthritis is a rare disease. A standard treatment for SCJ infection has not been established. This study aimed to assess the clinical outcomes of a three-stage procedure with bone transportation (BT) for treating SCJ infectious arthritis. METHODS: Six patients (mean age 39.5 years) with chronic SCJ infectious arthritis were included in the study. The patients underwent a three-stage treatment between January 2009 and December 2012, and results were analyzed retrospectively...
November 25, 2016: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/27876746/-the-cross-plastic-correction-of-the-soft-tissue-defect-on-the-neck-with-the-use-of-a-pectoral-flap-harvested-from-the-opposite-side
#20
A L Klochikhin, G I Markov, A L Chistyakov, N N Kosheleva
The authors describe a patient presenting with initially multiple metachronous cancer spreading over the right-handed side of the mouth floor and the right-handed part of the lower jaw. The patient who underwent cross-plastic surgery for the correction of the extensive soft tissue defect on the neck with the use of the musculocutaneous pectoral flap with the axial blood supply is described. The observation during the 14 year follow-up period confirmed the good functional outcome of the treatment.
2016: Vestnik Otorinolaringologii
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