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Dupuytren's

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https://www.readbyqxmd.com/read/28515727/basics-of-radiation-biology-when-treating-hyperproliferative-benign-diseases
#1
REVIEW
Franz Rödel, Claudia Fournier, Julia Wiedemann, Felicitas Merz, Udo S Gaipl, Benjamin Frey, Ludwig Keilholz, M Heinrich Seegenschmiedt, Claus Rödel, Stephanie Hehlgans
For decades, low- and moderate-dose radiation therapy (RT) has been shown to exert a beneficial therapeutic effect in a multitude of non-malignant conditions including painful degenerative muscoloskeletal and hyperproliferative disorders. Dupuytren and Ledderhose diseases are benign fibroproliferative diseases of the hand/foot with fibrotic nodules and fascial cords, which determine debilitating contractures and deformities of fingers/toes, while keloids are exuberant scar formations following burn damage, surgery, and trauma...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28507849/difference-in-success-treating-proximal-interphalangeal-and-metacarpophalangeal-joints-with-collagenase-results-of-208-treatments
#2
Karina Liv Hansen, Jens Christian Werlinrud, Søren Larsen, Tune Ipsen, Jens Lauritsen
BACKGROUND: Dupuytren disease (DD) is a fibroproliferative disorder of the palmar fasciae causing extension deficit and impaired hand function. Treatment with injection of collagenase clostridium histolyticum (CCH) is a nonsurgical treatment method. The aim of this study was to evaluate the difference in efficiency and recurrence at 12-month follow-up when treating metacarpophalangeal (MP) and proximal interphalangeal (PIP) joints with CCH. None of the patients had received previous treatments of their condition...
April 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28505213/dupuytren-s-disease-how-to-recognize-its-early-signs
#3
Thomas Auld, Joanne R Werntz
Palmar skin dimpling and nodule or cord formation signal advancing disease. Treatments vary in effectiveness--in part, depending on condition severity.
March 2017: Journal of Family Practice
https://www.readbyqxmd.com/read/28505187/recurrence-of-dupuytren-s-contracture-a-consensus-based-definition
#4
Hester J Kan, Frank W Verrijp, Steven E R Hovius, Christianne A van Nieuwenhoven, Ruud W Selles
PURPOSE: One of the major determinants of Dupyutren disease (DD) treatment efficacy is recurrence of the contracture. Unfortunately, lack of agreement in the literature on what constitutes recurrence makes it nearly impossible to compare the multiple treatments alternatives available today. The aim of this study is to bring an unbiased pool of experts to agree upon what would be considered a recurrence of DD after treatment; and from that consensus establish a much-needed definition for DD recurrence...
2017: PloS One
https://www.readbyqxmd.com/read/28490266/radiotherapy-in-dupuytren-s-disease-a-systematic-review-of-the-evidence
#5
M Kadhum, E Smock, A Khan, A Fleming
Radiotherapy has been advocated as an alternative treatment in early Dupuytren's disease. We have systematically reviewed the evidence on the use of radiotherapy in Dupuytren's disease. Only six articles met a minimum set standard, five of which were retrospective cohort studies and one a randomized controlled study. A total of 770 Dupuytren's hands, nearly all with Tubiana stage 0-1 disease, were irradiated with an average 30 Gy. Disease regression ranged from 0%-56%, stability from 14%-98% and progression from 2%-86%...
March 1, 2017: Journal of Hand Surgery, European Volume
https://www.readbyqxmd.com/read/28486091/angiotensin-receptors-in-dupuytren-s-disease-a-target-for-pharmacological-treatment
#6
Christopher Stephen, Leila Touil, Partha Vaiude, Jaipaul Singh, Stuart McKirdy
BACKGROUND: Attempts at the pharmacological treatment of Dupuytren's disease have so far been unsuccessful, and the disease is not yet fully understood on a cellular level. The Renin-Angiotensin System has long been understood to play a circulating hormonal role. However, there is much evidence showing Angiotensin II to play a local role in wound healing and fibrosis, with ACE inhibitors being widely used as an anti-fibrotic agent in renal and cardiac disease. METHODS: This study was designed to investigate the presence of Angiotensin II receptors 1 (AT1) and 2 (AT2) in Dupuytren's tissue to form a basis for further study into the pharmacological treatment of this condition...
May 9, 2017: Journal of Plastic Surgery and Hand Surgery
https://www.readbyqxmd.com/read/28473158/injectable-collagenase-versus-percutaneous-needle-fasciotomy-for-dupuytren-contracture-in-proximal-interphalangeal-joints-a%C3%A2-randomized-controlled-trial
#7
Simon Toftgaard Skov, Therkel Bisgaard, Per Søndergaard, Jeppe Lange
PURPOSE: Collagenase Clostridium histolyticum (CCH) injection was introduced commercially as a treatment for Dupuytren contracture following initial phase-3 investigations in 2009 with promising results. However, the efficacy of CCH has not been prospectively investigated in a direct comparison to other active treatments of Dupuytren contracture with more than 1-year follow-up, despite a wide and increasing clinical use. METHOD: In this prospective, independent, open-label, randomized controlled trial, (Clinicaltrials...
May 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28444647/-partial-fasciectomy-and-options-of-reconstruction-using-local-flaps-in-cases-of-dupuytren-s-disease
#8
N Spindler, C Josten, S Langer
Aim: Partial fasciectomy in cases of grade III-IV Dupuytren's contracture and coverage of the defect with local flaps. Indication: Dupuytren's contracture is a progressive disease of the hand associated with the formation of fascial cords, which may result in flexion and adduction contractures of the fingers leading up to complete dysfunction of the hands. Method: If several fingers are affected, partial fasciectomy is the gold standard in the treatment of Dupuytren's contracture. Ideally, the fingers reach the neutral position after the fibres causing the contracture are resected and arthrolysis is performed as needed...
April 2017: Zentralblatt Für Chirurgie
https://www.readbyqxmd.com/read/28423444/-comment-on-the-technique-of-enhanced-percutaneous-needle-fasciotomy-pnf-for-dupuytren-s-contracture
#9
Martin Richter
No abstract text is available yet for this article.
February 2017: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
https://www.readbyqxmd.com/read/28423443/-the-extended-percutaneous-needle-fasciotomy-technique-pnf-for-dupuytren-s-contracture
#10
Wolfgang Paul Lenze
The extended percutaneous needle fasciotomy (PNF+) is a minimal invasive technique especially suitable for treating severe Dupuytren's contractures and recurrences. The familiar needle fasciotomy is complemented by a spontaneous tearing of the skin and a full-thickness graft to cover the defect. Skin tears in fingers and palm are not a complication, but an integral part of the PNF+. The neurovascular bundles remain intact. This surgical procedure may be repeated as often as required.
February 2017: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
https://www.readbyqxmd.com/read/28418979/comment-on-percutaneous-aponeurotomy-and-lipofilling-palf-versus-limited-fasciectomy-in-patients-with-primary-dupuytren-s-contracture-a-prospective-randomized-controlled-trial
#11
Sören Könneker, Christine Radtke, Peter Maria Vogt
No abstract text is available yet for this article.
April 4, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28401820/-a-man-with-a-curved-deformity-of-the-hand
#12
E M van Soest, G J de Jong, L Korswagen
A 63-year-old male was seen at the rheumatology outpatient clinic because of a curved deformity of his left hand, with fixed flexion of the MCP joints and hyperextension of the PIP and DIP joints. This so-called striatal hand, a feature of Parkinson's disease, can easily be confused with rheumatoid arthritis or Dupuytren's contracture.
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28389081/the-use-of-residual-collagenase-for-single-digits-with-multiple-joint-dupuytren-contractures
#13
Louis C Grandizio, Anil Akoon, Janice Heimbach, Jove Graham, Joel C Klena
PURPOSE: Standard 0.58 mg (0.25 mL) collagenase Clostridium histolyticum (CCH) preparations result in unused CCH that is often discarded. Our purpose was to assess the results on Dupuytren contractures affecting both the metacarpophalangeal (MCP) and proximal interphalangeal (PIP) joints in the same digit utilizing an injection containing the maximum CCH volume that can be withdrawn from a single vial. METHODS: A consecutive series of patients with MCP and PIP cords in the same digit received a single treatment with 2 injections totaling 0...
April 4, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28383356/-hills-plains-and-valleys-a-topographical-concept-in-the-treatment-of-dupuytren-s-contracture-with-needle-aponeurotomy
#14
Roshin Thomas, Emmett O'Flaherty
Needle aponeurotomy is emerging as a preferred choice of treatment for patients with Dupuytren's contracture keen on a quick, minimally invasive procedure that enables a rapid return of hand function. This article describes a unique topographical concept in the treatment of Dupuytren's contracture with needle aponeurotomy. This concept guides portal placement in a planned manner to achieve better correction and avoid potential complications.
June 2017: Techniques in Hand & Upper Extremity Surgery
https://www.readbyqxmd.com/read/28382393/-dupuytren-s-disease-current-treatment-concepts
#15
EDITORIAL
Frank Unglaub, Christian K Spies
No abstract text is available yet for this article.
April 2017: Der Orthopäde
https://www.readbyqxmd.com/read/28374546/upper-extremity-arthropathy-in-diabetes
#16
EDITORIAL
Zachary Bloomgarden
Hou and coworkers used data analyzed nearly 60,000 persons with diabetes from the Taiwan National Health Insurance database in reporting a prevalence of 2.4% of diabetic hand syndrome, including carpal tunnel syndrome (in 1.2%), flexor tenosynovitis (also in 1.2%), and, much less frequently, limited joint mobility and Dupuytren's contracture.
April 4, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28363676/variable-operative-experience-in-hand-surgery-for-plastic-surgery-residents
#17
Jason Silvestre, Ines C Lin, Lawrence Scott Levin, Benjamin Chang
BACKGROUND: Efforts to standardize hand surgery training during plastic surgery residency remain challenging. We analyze the variability of operative hand experience at U.S. plastic surgery residency programs. METHODS: Operative case logs of chief residents in accredited U.S. plastic surgery residency programs were analyzed (2011-2015). Trends in fold differences of hand surgery case volume between the 10th and 90th percentiles of residents were assessed graphically...
March 28, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28361190/-the-fibrous-skeleton-of-the-hand-changes-with-dupuytren-s-contracture
#18
M F Langer, J Grünert, F Unglaub, B Wieskötter, S Oeckenpöhler
The exact knowledge of the anatomy of the fibrous skeleton of the hand is an absolute prerequisite for any treatment of Dupuytren's disease. The fibrous skeleton does not only include the palmar aponeurosis, but also numerous retinacula cutis, which are not found in current anatomy books. Here, eponyms facilitate the otherwise difficult and over-pronounced names of the fiber systems. Skoog, Legueu and Juvara, Gosset, Grapow, Grayson, Cleland, Thomine, and Barton are the most important. This systematic review of the fibers and strands is designed to help reduce iatrogenic complications...
March 30, 2017: Der Orthopäde
https://www.readbyqxmd.com/read/28341067/treatment-of-recurrent-dupuytren-contracture-in-joints-previously-effectively-treated-with-collagenase-clostridium-histolyticum
#19
Brian J Bear, Clayton A Peimer, F Thomas D Kaplan, Gregory J Kaufman, James P Tursi, Ted Smith
PURPOSE: Collagenase Clostridium histolyticum (CCH) is approved for the treatment of adults with Dupuytren contracture with a palpable cord. This open-label, phase 4 study evaluated the safety and efficacy of CCH for the retreatment of recurrent contractures in joints that were previously effectively treated with CCH. METHODS: Patients participating in a long-term follow-up study who had contracture recurrence (increased ≥ 20° with a palpable cord) after successful treatment in the previous study were eligible...
May 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28341038/acute-gout-following-dermofasciectomy-in-a-patient-with-dupuytren-disease
#20
Elliott Cochrane, Rosalyn Harper
A 62-year-old man underwent uncomplicated dermofasciectomy of the right little finger. In the week after surgery, he presented with erythema, tenderness, reduced range of movement, and a chalklike discharge from the suture line. Investigations revealed a raised serum urate level accompanied with a borderline rise in inflammatory markers. A diagnosis of acute gout was made. The patient was managed with nonsteroidal anti-inflammatory drugs. Clinicians should consider the diagnosis of gout when patients present after surgery with redness, pain, and swelling and also consider measuring urate levels before surgery and initiating colchicine prophylaxis when there is a known diagnosis of gout before surgery...
January 2017: Journal of Hand Surgery
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