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Dupuytren's

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https://www.readbyqxmd.com/read/28917432/complications-after-treating-dupuytren-s-disease-a-systematic-literature-review
#1
C Krefter, M Marks, S Hensler, D B Herren, M Calcagni
The objective of this study was to review the incidence of complications associated with different treatment options for patients with Dupuytren's disease. In a systematic literature review, the PubMed, EMBASE, Cochrane and Scopus databases were searched for clinical studies reporting complications after collagenase treatment, percutaneous needle fasciotomy (PNF), fasciectomy and dermofasciectomy. The incidence of complications was extracted from each study and stratified by procedure. From a total of 2251 references, 113 studies were analyzed and included with complication incidences varying from 0% to 100%...
September 13, 2017: Hand Surgery and Rehabilitation
https://www.readbyqxmd.com/read/28886342/a-genome-wide-association-study-of-dupuytren-disease-reveals-17-additional-variants-implicated-in-fibrosis
#2
Michael Ng, Dipti Thakkar, Lorraine Southam, Paul Werker, Roel Ophoff, Kerstin Becker, Michael Nothnagel, Andre Franke, Peter Nürnberg, Ana Isabel Espirito-Santo, David Izadi, Hans Christian Hennies, Jagdeep Nanchahal, Eleftheria Zeggini, Dominic Furniss
Individuals with Dupuytren disease (DD) are commonly seen by physicians and surgeons across multiple specialties. It is an increasingly common and disabling fibroproliferative disorder of the palmar fascia, which leads to flexion contractures of the digits, and is associated with other tissue-specific fibroses. DD affects between 5% and 25% of people of European descent and is the most common inherited disease of connective tissue. We undertook the largest GWAS to date in individuals with a surgically validated diagnosis of DD from the UK, with replication in British, Dutch, and German individuals...
September 7, 2017: American Journal of Human Genetics
https://www.readbyqxmd.com/read/28885215/hyperspectral-imaging-as-a-novel-diagnostic-tool-in-microcirculation-of-wounds
#3
Georg Daeschlein, Inga Langner, Thomas Wild, Sebastian von Podewils, Claudia Sicher, Thomas Kiefer, Michael Jünger
Monitoring of perfusion is a cornerstone in surgery, phlebology and basic science to proof wound healing by interventions. In chronic wound management it is of utmost importance to realize and parametrize wound bed perfusion to verify actual, and plan further treatment by noninvasive diagnostics. Up to now monitoring is based on visual inspection of wounds as conventionally practiced over more than decades. The main problems of visual inspection are the lack of standardization and comparability because of interindividual variations...
September 4, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/28871791/real-time-bioimpedance-sensing-of-antifibrotic-drug-action-in-primary-human-cells
#4
Maryam Parviz, Priyanka Toshniwal, Helena Viola, Livia C Hool, P Mark W Fear, Fiona Wood, Katharina Gaus, K Swaminathan Iyer, John Justin Gooding
Fibrotic diseases are among the most serious health issues with severe burdens due to their chronic nature and a large number of patients suffering from the debilitating effects and long-term sequelae. Collagenase treatment is a non-surgical option but has limited results. To date, there is no potent non-invasive solution for fibrosis. Part of the reason for this is the lack of appropriate in vitro live cell screening tools to assess the efficacy of new therapeutical agents. Here, we demonstrate the utility of a cell-based electrochemical impedance biosensor platform to screen the efficacy of potential antifibrotic compounds...
September 5, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28867249/night-orthosis-after-surgical-correction-of-dupuytren-contractures-a-systematic%C3%A2-review
#5
Osama A Samargandi, Sarah Alyouha, Patricia Larouche, Joseph P Corkum, Marius A Kemler, David T Tang
PURPOSE: To determine the role of night orthosis use after surgical correction of Dupuytren contracture. METHODS: We searched MEDLINE, EMBASE, CINAHL, AMED, OTSeeker, and CENTRAL for articles published from inception of the databases to August 2015. Assessment was undertaken by 2 independent reviewers (O.A.S. and S.A.). Methodological quality of randomized controlled trials was assessed using the Cochrane risk of bias tool and the Newcastle-Ottawa instrument. RESULTS: Seven studies met the standard for inclusion in this review...
August 31, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28860097/effectiveness-of-conservative-surgical-and-post-surgical-interventions-for-trigger-finger-dupuytren-s-disease-and-de-quervain-s-disease-a-systematic-review
#6
REVIEW
Bionka M Huisstede, Saskia Gladdines, Manon S Randsdorp, Bart W Koes
OBJECTIVES: To provide an evidence-based overview of the effectiveness of conservative and (post)-surgical interventions for trigger finger, Dupuytren's -, and De Quervain's disease. DATA SOURCES: The Cochrane Library, PEDro, PubMed, Embase and CINAHL were searched to identify relevant systematic reviews and RCTs. DATA SELECTION AND EXTRACTION: Two reviewers independently extracted the data, and assessed the methodological quality. DATA SYNTHESIS: A best-evidence synthesis was performed to summarize the results...
August 28, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28854973/efficacy-and-safety-of-collagenase-clostridium-histolyticum-for-dupuytren-disease-nodules-a-randomized-controlled-trial
#7
Bronier Costas, Stephen Coleman, Greg Kaufman, Robert James, Brian Cohen, R Glenn Gaston
BACKGROUND: To determine the safety and efficacy of collagenase clostridium histolyticum (CCH) injection for the treatment of palmar Dupuytren disease nodules. METHODS: In this 8-week, double-blind trial, palpable palmar nodules on one hand of adults with Dupuytren disease were selected for treatment. Patients were randomly assigned using an interactive web response system to receive a dose of 0.25 mg, 0.40 mg, or 0.60 mg (1:1:1 ratio) and then allocated to active treatment (CCH) or placebo (4:1 ratio)...
August 30, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28843342/readability-of-online-materials-for-dupuytren-s-contracture
#8
Pauline Joy F Santos, David A Daar, Austin Badeau, Amber Leis
STUDY DESIGN: Descriptive. BACKGROUND: Dupuytren's contracture is a common disorder involving fibrosis of the palmar fascia. As patients are increasingly using online materials to gather health care information, it is imperative to assess the readability and appropriateness of this content. The recommended grade level for patient educational materials is seventh to eighth grade according to the National Institutes of Health. This study aims to assess the readability and content of online patient resources for Dupuytren's contracture...
August 23, 2017: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
https://www.readbyqxmd.com/read/28841903/a-feasibility-study-investigating-the-acceptability-and-design-of-a-multicentre-randomised-controlled-trial-of-needle-fasciotomy-versus-limited-fasciectomy-for-the-treatment-of-dupuytren-s-contractures-of-the-fingers-hand-1-study-protocol-for-a-randomised-controlled
#9
Eleanor Harrison, Wei Tan, Nicola Mills, Alexia Karantana, Kirsty Sprange, Lelia Duley, Daisy Elliott, Jane Blazeby, William Hollingworth, Alan A Montgomery, Tim Davis
BACKGROUND: Dupuytren's contractures are fibrous cords under the skin of the palm of the hand. The contractures are painless but cause one or more fingers to curl into the palm, resulting in loss of function. Standard treatment within the NHS is surgery to remove (fasciectomy) or divide (fasciotomy) the contractures, and the treatment offered is frequently determined by surgeon preference. This study aims to determine the feasibility of conducting a large, multicentre randomised controlled trial to assess the clinical and cost-effectiveness of needle fasciotomy versus limited fasciectomy for the treatment of Dupuytren's contracture...
August 25, 2017: Trials
https://www.readbyqxmd.com/read/28841617/benefit-of-local-anesthesia-in-reducing-pain-during-collagenase-injection-for-dupuytren-s-contracture
#10
Jesper Nordenskjöld, Markus Waldén, Anders Kjellin, Herbert Franzén, Isam Atroshi
Collagenase injection for Dupuytren's contracture is commonly administered without anesthesia. The authors studied the benefit of injecting local anesthesia before collagenase in reducing treatment-related pain. This prospective cohort study included 187 patients (mean age, 69 years; 80 percent men) at two orthopedic departments in Sweden. At one center, 161 consecutive patients scheduled for collagenase injection were assigned to two groups by alternating outpatient clinics; 78 received collagenase without local anesthesia using a modified method (injecting 0...
September 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28836453/readability-of-the-most-commonly-accessed-online-patient-education-materials-pertaining-to-pathology-of-the-hand
#11
Sheriff D Akinleye, Garret Garofolo-Gonzalez, Michael Montuori, Maya Deza Culbertson, Jennifer Hashem, David Marc Edelstein
BACKGROUND: The American Medical Association (AMA) and National Institutes of Health (NIH) recommend that patient education materials be written at no higher than a sixth-grade reading level. METHODS: We examined 100 online educational materials for the 10 hand conditions most commonly treated by hand surgeons, as reported by the American Society for Surgery of the Hand. The listed conditions were carpal tunnel syndrome, basal joint arthritis of the thumb, de Quervain syndrome, Dupuytren's contracture, ganglion cysts, hand fractures, trigger finger, extensor tendon injuries, flexor tendon injuries, and mallet finger...
August 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28831359/embryonic-stem-cell-like-population-in-dupuytren-s-disease-expresses-components-of-the-renin-angiotensin-system
#12
Nicholas On, Sabrina P Koh, Helen D Brasch, Jonathan C Dunne, James R Armstrong, Swee T Tan, Tinte Itinteang
The renin-angiotensin system (RAS) mediates cardiac and renal fibrosis. Dupuytren's disease (DD) is a proliferative fibromatosis affecting the hands. This study investigated the expression of the RAS in DD. METHODS: 3,3-Diaminobenzidine (DAB) and immunofluorescent immunohistochemical (IHC) staining for (pro)renin receptor (PRR), angiotensin-converting enzyme (ACE), angiotensin II receptor 1 (ATIIR1), and angiotensin II receptor 2 (ATIIR2) was performed on 4-μm thick formalin-fixed paraffin-embedded sections of DD cords and nodules from 6 patients...
July 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28816972/low-second-to-fourth-digit-ratio-in-dupuytren-disease
#13
Takuya Yokoi, Takuya Uemura, Kenichi Kazuki, Ema Onode, Kosuke Shintani, Mitsuhiro Okada, Hiroaki Nakamura
The ratio of the lengths of the second and fourth digits (2D:4D) has been described as reflecting endogenous prenatal androgen exposure. In general, 2D:4D is lower in men than in women and has potential as a biomarker or predictor for various diseases, athletic ability, and academic performance. Dupuytren disease has digital flexion contractures and is known to predominate in men, but the pathogenesis of the disease remains unclear. To clarify the relationships between Dupuytren disease and endogenous androgens, we performed a retrospective analysis of hand radiographs to investigate 2D:4D in Dupuytren disease...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28806826/-treatment-of-dupuytren-s-disease-with-collagenase-injections-in-germany-efficacy-and-adverse-effects-in-110-treated-joints
#14
Adrian Pototschnig, Elias Volkmer, Riccardo E Giunta
Background Since 2011, a new minimally-invasive treatment for Dupuytren's disease has been available in the form of injectable collagenase (Xiapex®, Pfizer). Purpose Our aim is to report about the results and adverse effects of injectable collagenase for the treatment of Dupuytren's disease in Germany. Patients and Methods We treated 78 patients (61 male, 17 female) with 87 injections in 87 digits (little finger n = 40, ring finger n = 37, middle finger n = 8 and index n = 2). We documented the range of motion before treatment, after 6 weeks and after 6 months...
August 2017: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
https://www.readbyqxmd.com/read/28806825/-completeness-and-reproducibility-of-surgical-reports-a%C3%A2-retrospective-analysis-of-documentation-quality-using-the-example-of-dupuytren-s-disease
#15
Elisabeth Russe, Andrea Wenger, Gottfried Wechselberger, Hildegunde Piza-Katzer
Background A surgical report is the surgeon's postoperative documentation of the procedure undertaken. The purpose of this study was to evaluate the completeness and accuracy of data extracted from surgical reports, using the example of Dupuytren's disease. Material and Methods Between 1999 and 2007, surgical data were retrospectively collected from all primary Dupuytren's disease procedures performed at an academic department for plastic and reconstructive surgery and analysed for completeness. A surgical report was assessed as complete if data on indication, affected side and finger(s), tourniquet, type of incision and surgical procedure were stated...
August 2017: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
https://www.readbyqxmd.com/read/28774258/the-hand-of-sabazios-evidence-of-dupuytren-s-disease-in-antiquity-and-the-origin-of-the-hand-of-benediction
#16
Matthew J Zdilla
Dupuytren's disease gained its eponym from the surgeon Baron Guillaume Dupuytren (1777-1835). However, the terms "Cline's contracture" and "Cooper's contracture," named after the two surgeons who proposed the treatment for the palmar contractures prior to Dupuytren, have also been used to describe the disease. In addition to the eponyms attributed to these three surgeons, a number of other appellations with interesting provenance exist for Dupuytren's disease including the "Curse of the MacCrimmons," "Celtic hand," "Viking's disease," and the "Hand of Benediction...
September 2017: Journal of Hand Surgery Asian-Pacific Volume
https://www.readbyqxmd.com/read/28774253/predictors-of-outcomes-following-fasciectomy-for-dupuytren-s-disease-in-diabetic-and-non-diabetic-patients
#17
Eitan Melamed, Bryan G Beutel, Shaul Goldstein, David Angel
BACKGROUND: The aim of this study was to compare clinical outcomes, and identify predictors thereof, after fasciectomy for Dupuytren's disease in a series of diabetic patients compared with non-diabetic patients. METHODS: Thirty-eight patients were examined following partial palmar and/or digital fasciectomy for Dupuytren's disease (11 diabetics, 27 non-diabetics). Each patient was assessed for degree of pre- and post-operative flexion contractures at the MCP and PIP joints, post-operative Patient Evaluation Measure (PEM) total score, post-operative grip strength, limited joint mobility (LJM), recurrence, extension, and a composite outcomes score based upon grip strength and the degree of joint contractures...
September 2017: Journal of Hand Surgery Asian-Pacific Volume
https://www.readbyqxmd.com/read/28732844/efficacy-and-safety-of-collagenase-treatment-for-dupuytren-s-disease-2-year-follow-up-results
#18
A Van Beeck, M Van den Broek, M Michielsen, K Didden, K Vuylsteke, F Verstreken
Dupuytren's contracture is a common hand problem that affects the palmar fascia. Several treatment options exist, but none are curative and recurrence is common. Bacterial collagenase has recently been proven beneficial for treating Dupuytren's disease, cleaving the collagen fibers at different sites, with weakening and eventually rupture of the fibrous cords after manipulation. An independent prospective follow-up study was organized on 87 patients, treated with one or more collagenase injections. Inclusion criteria were a contracture of at least 20° at the metacarpophalangeal (MCP) or the proximal interphalangeal (PIP) joint...
July 18, 2017: Hand Surgery and Rehabilitation
https://www.readbyqxmd.com/read/28732843/preliminary-results-with-non-centrifuged-autologous-fat-graft-and-percutaneous-aponeurotomy-for-treating-dupuytren-s-disease
#19
U Tuncel, A Kurt, M Gumus, O Aydogdu, N Güzel, O Demir
The aim of this study was to describe our experience with treating Dupuytren's disease using needle aponeurotomy and non-centrifuged autologous fat grafting. The study included 17 patients (18 hands). Patients were treated with needle aponeurotomy and non-centrifuged autologous fat graft under general anesthesia. The fat grafts were injected into the surgical area so as to stay in contact with the operated site. An extension splint was used for 1 week postoperatively and the patients received hand therapy for 3 weeks...
July 18, 2017: Hand Surgery and Rehabilitation
https://www.readbyqxmd.com/read/28705609/hand-shoulder-and-back-stiffness-in-long-term-type-1-diabetes-cross-sectional-association-with-skin-collagen-advanced-glycation-end-products-the-dialong-study
#20
Kristine Bech Holte, Niels Gunnar Juel, Jens Ivar Brox, Kristian Folkvord Hanssen, Dag Sigurd Fosmark, David R Sell, Vincent M Monnier, Tore Julsrud Berg
AIMS: We aimed to: (i) estimate the prevalence of Dupuytren's disease, trigger finger, carpal tunnel syndrome and frozen shoulder; (ii) assess stiffness of the hand, shoulder and back; and (iii) explore the association of joint stiffness with both long-term HbA1c and collagen advanced glycation end-products (AGEs) in long-term type 1 diabetes mellitus (T1DM). METHODS: Patients with T1DM from 1970 or earlier attending a specialized diabetes center were included in this cross-sectional controlled study...
June 22, 2017: Journal of Diabetes and its Complications
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