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https://www.readbyqxmd.com/read/27885382/mri-in-flexor-tendon-rupture-after-collagenase-injection
#1
Shruti Khurana, Vibhor Wadhwa, Avneesh Chhabra, Bardia Amirlak
Flexor tendon rupture is an unusual complication following collagenase injection to relieve contractures. These patients require a close follow-up and in the event of tendon rupture, a decision has to be made whether to repair the tendon or manage the complication conservatively. The authors report the utility of MRI in the prognostication and management of a patient with Dupuytren's contracture, who underwent collagenase injection and subsequently developed flexor digitorum profundus tendon rupture.
November 25, 2016: Skeletal Radiology
https://www.readbyqxmd.com/read/27884015/joseph-fr%C3%A3-d%C3%A3-ric-beno%C3%A3-t-charri%C3%A3-re-how-to-explain-his-success-as-one-of-the-most-famous-surgical-instrument-makers-regarding-his-life-from-childhood-to-death
#2
Jasmin Katrin Badawi
INTRODUCTION: We use the name 'Charrière' every day as a unit of measurement. This article explains his success as one of the most famous instrument makers who ever lived. MATERIALS AND METHODS: A review of the literature was completed using PubMed. Additionally, material of historical sources like the museum of Bulle was used. RESULTS: Joseph-Frédéric-Benoît Charrière was born in Switzerland in 1803. At the age of 13, he moved to Paris and learned the profession of a cutler...
November 25, 2016: Urologia Internationalis
https://www.readbyqxmd.com/read/27872343/recovery-responsiveness-and-interpretability-of-patient-reported-outcome-measures-after-surgery-for-dupuytren-s-disease
#3
J N Rodrigues, W Zhang, B E Scammell, D Davidson, S Fullilove, I Chakrabarti, P G Russell, T R C Davis
: This prospective cohort study investigated the responsiveness and interpretability of the Disabilities of the Arm, Shoulder and Hand (DASH) and Unité Rhumatologique des Affections de la Main (URAM) outcome measures for assessing recovery after fasciectomy and dermofasciectomy for Dupuytren's disease. DASH outcome scores at 1 year were significantly better than at 6 weeks, suggesting that recovery is not complete by 6 weeks. Of the 101 patients recruited to the DASH cohort, 71 completed preoperative, 6 week and 1 year postoperative DASH scores; 68 of them completed preoperative and 1 year postoperative DASH scores and an external anchor question...
November 20, 2016: Journal of Hand Surgery, European Volume
https://www.readbyqxmd.com/read/27872008/the-genetic-basis-of-peyronie-disease-a-review
#4
REVIEW
Amin S Herati, Alexander W Pastuszak
INTRODUCTION: Peyronie disease (PD) is a progressive fibrotic disorder of the penile tunica albuginea that results in fibrotic penile plaques and can lead to penile deformity. Characterized by aberrant fibrosis resulting in part from the persistence of myofibroblasts and altered gene expression, the molecular factors underpinning PD and other related fibrotic diatheses are just being elucidated. A genetic link to PD was first identified three decades ago using pedigree analyses. However, the specific genetic factors that predispose patients to aberrant fibrosis remain unknown, and the relations between these fibrotic conditions and other heritable diseases, including malignancy, are uncharacterized...
January 2016: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/27835939/anti-fibrotic-action-of-pirfenidone-in-dupuytren-s-disease-derived-fibroblasts
#5
Chaoming Zhou, Fang Liu, Phillip H Gallo, Mark E Baratz, Sandeep Kathju, Latha Satish
BACKGROUND: Dupuytren's disease (DD) is a complex fibro-proliferative disorder of the hand that is often progressive and eventually can cause contractures of the affected fingers. Transforming growth factor beta (TGF-β1) has been implicated as a key stimulator of myofibroblast activity and fascial contraction in DD. Pirfenidone (PFD) is an active small molecule shown to inhibit TGF-β1-mediated action in other fibrotic disorders. This study investigates the efficacy of PFD in vitro in inhibiting TGF-β1-mediated cellular functions leading to Dupuytren's fibrosis...
November 11, 2016: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/27798003/medical-claims-based-case-control-study-of-temporal-relationship-between-clinical-visits-for-hand-syndromes-and-subsequent-diabetes-diagnosis-implications-for-identifying-patients-with-undiagnosed-type-2-diabetes-mellitus
#6
Wen-Hsuan Hou, Chung-Yi Li, Lu-Hsuan Chen, Liang-Yi Wang, Li-Chieh Kuo, Ken N Kuo, Hsiu-Nien Shen, Chang-Ta Chiu
OBJECTIVES: To investigate whether a temporal relationship is present between clinical visits for diabetes-related hand syndromes (DHSs) and subsequent type 2 diabetes mellitus (T2DM) diagnosis and, accordingly, whether DHSs can be used for identifying patients with undiagnosed T2DM. DESIGN: This study had a case-control design nested within a cohort of 1 million people from the general population, which was followed from 2005 to 2010. The odds of prior clinical visits for DHSs, namely carpal tunnel syndrome (CTS), flexor tenosynovitis, limited joint mobility and Dupuytren's disease, were estimated for cases and controls...
October 20, 2016: BMJ Open
https://www.readbyqxmd.com/read/27783110/-arthrodesis-of-the-proximal-interphalangeal-joint-of-fingers-with-tension-band-wire
#7
B Hohendorff, J Franke, C K Spies, L P Müller, C Ries
OBJECTIVE: Arthrodesis of the proximal interphalangeal joint of fingers in a functional and pain-free position. INDICATIONS: Primary and secondary osteoarthritis, traumatic joint destruction, posttraumatic malposition, instability, joint destruction due to infection, irreparable extensor and/or flexor tendon lesion, recurrent flexion deformity in Dupuytren's disease, arthritis (e. g., rheumatoid arthritis, psoriatic arthritis), failed resection arthroplasty, failed prosthesis, congenital disorder (e...
October 25, 2016: Operative Orthopädie und Traumatologie
https://www.readbyqxmd.com/read/27781989/proximodistal-interphalangeal-arthrodesis-of-the-little-finger-a-series-of-7-cases
#8
S Honecker, J J Hidalgo Diaz, K Naito, E Pire, G Prunières, S Facca, P Liverneaux
As an alternative to amputation of the little finger, we report here seven cases of shortening arthrodesis carried out by resecting the middle phalanx and proximodistal interphalangeal (PDIP) arthrodesis. Our cohort consisted of 6 males and 1 female (58years average age), with a stiff little finger secondary to Dupuytren's disease or trauma. All fingers were approached dorsally; after resection of the middle phalanx and decortication of the subchondral bone, fusion of the remaining phalanges was performed using an intramedullary self-breaking screw-pin...
September 2016: Hand Surgery and Rehabilitation
https://www.readbyqxmd.com/read/27760243/treatment-of-dupuytren-contracture-with-injectable-collagenase-within-the-veterans-affairs-system
#9
Stephen Duquette, Ryan Kuster, Tyler Evans, William Wooden, Imtiaz Munshi, Adam Cohen, Sunil S Tholpady
No abstract text is available yet for this article.
October 19, 2016: JAMA Surgery
https://www.readbyqxmd.com/read/27747514/collagenase-treatment-in-dupuytren-contractures-a-review-of-the-current-state-versus-future-needs
#10
Ilse Degreef
Dupuytren disease is highly prevalent and the finger contractures can be very extensile, compromising the patients' hand function. To restore full function, contractures have been addressed by cutting the causative strands for nearly 200 years, ever since Baron Guillaume Dupuytren demonstrated his technique at the beginning of the nineteenth century. Surgery can be minimal (fasciotomy) or quite invasive (fasciectomy and even skin replacement). However, in the last decade translational research has introduced the non-surgical technique of enzymatic fasciotomy with collagenase injections...
June 2016: Rheumatology and Therapy
https://www.readbyqxmd.com/read/27720205/a-novel-conformal-superficial-high-dose-rate-brachytherapy-device-for-the-treatment-of-nonmelanoma-skin-cancer-and-keloids
#11
Clara Ferreira, Daniel Johnson, Karl Rasmussen, Clinton Leinweber, Salahuddin Ahmad, Jae Won Jung
PURPOSE: To develop a novel conformal superficial brachytherapy (CSBT) device as a treatment option for the patient-specific radiation therapy of conditions including superficial lesions, postsurgical positive margins, Dupuytren's contractures, keloid scars, and complex anatomic sites (eyelids, nose, ears, etc.). METHODS AND MATERIALS: A preliminary CSBT device prototype was designed, built, and tested using readily available radioactive seeds. Iodine-125 ((125)I) seeds were independently guided to the treatment surface to conform to the target...
October 3, 2016: Brachytherapy
https://www.readbyqxmd.com/read/27682305/effectiveness-and-safety-of-collagenase-clostridium-histolyticum-in-dupuytren-s-disease%C3%A2-an-observational-study-in-belgium
#12
F Verstreken, I Degreef, A Decramer, K Libberecht, W Vanhove, A Datco, J Vanhaecke, D Clermont, J Duerinckx
Dupuytren's disease is a connective tissue disorder leading to contractures. It can be treated surgically or through injections of collagenase Clostridium histolyticum (CCH). Patients with Dupuytren's contracture (> 20°) and a palpable cord were included in this observational study, aiming to characterise the Belgian patient population and to assess the effectiveness and safety of CCH. Overall, 108 patients (114 joints) received at least one injection of CCH, and 104 patients completed the study. The percentages of joints achieving a degree of contracture of 5° or less, or a relative contracture reduction of at least 50% after the extension procedure were 64...
August 2016: Acta Orthopaedica Belgica
https://www.readbyqxmd.com/read/27660370/dupuytren-disease-is-highly-prevalent-in-male-field-hockey-players-aged-over-60%C3%A2-years
#13
Dieuwke C Broekstra, Edwin R van den Heuvel, Rosanne Lanting, Tom Harder, Inge Smits, Paul M N Werker
BACKGROUND/AIM: Dupuytren disease is a fibroproliferative hand condition. The role of exposure to vibration as a risk factor has been studied with contradictory results. Since field hockey is expected to be a strong source of hand-arm vibration, we hypothesised that long-term exposure to field hockey is associated with Dupuytren disease. METHODS: In this cross-sectional cohort study, the hands of 169 male field hockey players (IQR: 65-71 years) and 156 male controls (IQR: 59-71 years) were examined for signs of Dupuytren disease...
September 22, 2016: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/27649672/toxic-dermatitis-secondary-to-treatment-with-collagenase-clostridium-histolyticum-for-dupuytren%C3%A2-s-disease
#14
R Sanjuan-Cervero, J E Poquet-Jornet, F J Carrera-Hueso
OBJECTIVE: Secondary effects and drug reactions relative to collagenase Clostridium histolyticum treatment for Dupuytren's contracture are frequent. In only a few cases these secondary effects are considered serious. The mechanism that produces these effects of production is not well understood. CLINICAL REPORT: We present the case report of a woman with fifth finger interphalangeal joint treatment with generalized skin rash as a complication of collagenase Clostridium histolyticum treatment...
September 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27617187/connective-tissue-degeneration-mechanisms-of-palmar-fascia-degeneration-dupuytren-s-disease
#15
S Karkampouna, M Kreulen, M C Obdeijn, P Kloen, A L Dorjée, F Rivellese, A Chojnowski, I Clark, Marianna Kruithof-de Julio
Dupuytren's disease is a connective tissue disorder of the hand causing excessive palmar fascial fibrosis with associated finger contracture and disability. The aetiology of the disease is heterogeneous, with both genetic and environmental components. The connective tissue is abnormally infiltrated by myofibroblasts that deposit collagen and other extracellular matrix proteins. We describe the clinical profile of Dupuytren's disease along with current therapeutic schemes. Recent findings on molecular and cellular parameters that are dysregulated in Dupuytren's disease, which may contribute to the onset of the disease, and the role of resident inflammation promoting fibrosis, are highlighted...
2016: Current Molecular Biology Reports
https://www.readbyqxmd.com/read/27608694/dupuytren-s-contracture-associated-with-long-standing-diabetes-mellitus
#16
N Nand, S Dsouza, N Batra, V Chauhan, M Yadav
No abstract text is available yet for this article.
October 2015: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27601465/remembered-preoperative-quick-disabilities-of-the-arm-shoulder-and-hand-quickdash-scores
#17
A H Wormdal, S H Tallaksen, Ø Hagen, O E Foss, V Finsen
: The Quick disabilities of the arm, shoulder and hand (QuickDASH) patient-reported outcome measure is frequently used to assess disabilities and symptoms of the upper extremity. This study compares real preoperative QuickDASH scores and remembered preoperative QuickDASH scores. Remembered preoperative QuickDASH scores were obtained 45 months (39-67) after surgery. Patient material consisted of 160 patients operated for Dupuytren's contracture, carpal tunnel syndrome, thumb basal joint arthrosis, and shoulder pain...
September 5, 2016: Journal of Hand Surgery, European Volume
https://www.readbyqxmd.com/read/27556605/predictors-of-patient-satisfaction-with-hand-function-after-fasciectomy-for-dupuytren-s-contracture
#18
Chao Zhou, Steven E R Hovius, Harm P Slijper, Michiel J Zuidam, Xander Smit, Reinier Feitz, Ruud W Selles
BACKGROUND: This study examined patient satisfaction with hand function after fasciectomy for Dupuytren's contracture and determined which preoperative patient- and disease-specific factors predicted this satisfaction. METHODS: Demographics and disease-specific factors were assessed from a prospective cohort of 194 patients who completed the Michigan Hand Outcomes Questionnaire preoperatively and underwent limited fasciectomy between 2011 and 2014 at six hand surgery practice sites...
September 2016: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27547932/-comparative-cost-effectiveness-of-clostridium-histolyticum-collagenase-xiapex%C3%A2-and-partial-fasciectomy-for-the-treatment-of-dupuytren-s-contracture-in-austria
#19
M Neuwirth, A Binter, W Pipam, M Rab
INTRODUCTION: Since Dupuytren's contracture is a common disorder, the costs for its surgical treatment impose a considerable burden on the healthcare system. For the first time in the German-speaking area, this study aimed to provide a comparative cost-effectiveness analysis for partial fasciectomy vs. treatment with Clostridium histolyticum collagenase (CCH). METHODS: A retrospective monocentric study of the period from 2012 to 2014 comprised 40 patients with previously untreated Dupuytren's contracture of one finger...
August 2016: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
https://www.readbyqxmd.com/read/27546441/the-impact-of-collagenase-clostridium-histolyticum-introduction-on-dupuytren-treatment-patterns-in-the-united-states
#20
John Z Zhao, Scott Hadley, Emerson Floyd, Brandon E Earp, Philip E Blazar
PURPOSE: The U.S. Food and Drug Administration approved the use of collagenase Clostridium histolyticum (CCH) in the United States in February 2010. This study addresses the impact of that approval on the number of Dupuytren contracture (DC) encounters and treatment patterns in the United States. METHODS: Using the Intercontinental Marketing Services Health Office-Based Medical Claims database, we identified the monthly number of DC encounters and DC procedures between January 2007 and December 2013...
October 2016: Journal of Hand Surgery
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