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prognostic index

Jae Won Park, Dong Hoon Koh, Won Sik Jang, Joo Yong Lee, Kang Su Cho, Won Sik Ham, Koon Ho Rha, Woo Hee Jung, Sung Joon Hong, Young Deuk Choi
PURPOSE: Prostate cancer (PC) is a devastating and heterogeneous condition with diverse treatment options. When selecting treatments for patients with very high-risk PC, clinicians must consider patient comorbidities. We investigated the efficacy of the age-adjusted Charlson Comorbidity Index (ACCI) as a prognostic factor for patient outcomes after radical prostatectomy (RP). MATERIALS AND METHODS: We retrospectively investigated the medical records of PC patients at our institution who underwent RP from 1992 to 2010...
2018: PloS One
Julián Pérez-Beteta, David Molina-García, José A Ortiz-Alhambra, Antonio Fernández-Romero, Belén Luque, Elena Arregui, Manuel Calvo, José M Borrás, Bárbara Meléndez, Ángel Rodríguez de Lope, Raquel Moreno de la Presa, Lidia Iglesias Bayo, Juan A Barcia, Juan Martino, Carlos Velásquez, Beatriz Asenjo, Manuel Benavides, Ismael Herruzo, Antonio Revert, Estanislao Arana, Víctor M Pérez-García
Purpose To evaluate the prognostic and predictive value of surface-derived imaging biomarkers obtained from contrast material-enhanced volumetric T1-weighted pretreatment magnetic resonance (MR) imaging sequences in patients with glioblastoma multiforme. Materials and Methods A discovery cohort from five local institutions (165 patients; mean age, 62 years ± 12 [standard deviation]; 43% women and 57% men) and an independent validation cohort (51 patients; mean age, 60 years ± 12; 39% women and 61% men) from The Cancer Imaging Archive with volumetric T1-weighted pretreatment contrast-enhanced MR imaging sequences were included in the study...
July 2018: Radiology
Huai-Hsuan Huang, Fei-Yuan Hsiao, Li-Ju Chen, Ho-Min Chen, Bor-Sheng Ko
BACKGROUND: Diffuse large B cell lymphoma (DLBCL) is the most common non-Hodgkin lymphoma. The treatment response and overall survival (OS) improved after incorporating rituximab with chemotherapies. Yet, available evidence as to whether women and men may benefit similarly from rituximab have not been adequately addressed, particularly in the real-world setting. The objective of this study was to examine sex differences in the clinical outcomes of rituximab in DLBCL patients using the Taiwan Cancer Registry Database and National Health Insurance Research Database...
June 20, 2018: Journal of Women's Health
Emily Morell Balkin, Matt S Zinter, Satish K Rajagopal, Roberta L Keller, Jeffrey R Fineman, Martina A Steurer
OBJECTIVES: The disease burden and mortality of children with pulmonary hypertension are significantly higher than for the general PICU population. We aimed to develop a risk-adjustment tool predicting PICU mortality for pediatric pulmonary hypertension patients: the Pediatric Index of Pulmonary Hypertension Intensive Care Mortality score. DESIGN: Retrospective analysis of prospectively collected multicenter pediatric critical care data. SETTING: One-hundred forty-three centers submitting data to Virtual Pediatric Systems database between January 1, 2009, and December 31, 2015...
June 19, 2018: Pediatric Critical Care Medicine
Ankita Singh, Prateek Bhatia, Amita Trehan, Deepak Bansal, Ajit Singh, Alka Bhatia
Background & objectives: Significance of apoptosis as a prognostic marker is less well studied in paediatric acute lymphoblastic leukaemia (ALL) cases. Hence, a prospective study, involving 30 paediatric ALL cases, was done to assess the clinical relevance of in vivo apoptosis. Methods: Peripheral blood mononuclear cells from all patients were subjected to annexin V/propidium iodide staining to detect the degree of apoptosis [apoptotic index (AI)] at day 0 and day 35 post-induction chemotherapy...
March 2018: Indian Journal of Medical Research
Karine Renaudin, Sarra Smati, Matthieu Wargny, Abir Al Ghuzlan, Sébastien Aubert, Emmanuelle Leteurtre, Martine Patey, Mathilde Sibony, Nathalie Sturm, Frédérique Tissier, Laurence Amar, Jérôme Bertherat, Claudine Berthozat, Olivier Chabre, Christine Do Cao, Magalie Haissaguerre, Peggy Pierre, Claire Briet, Delphine Vezzosi, Jean Christophe Lifante, François Pattou, Eric Mirallie, Eric Baudin, Bertrand Cariou, Rossella Libe, Delphine Drui
Oncocytic adrenocortical tumors are a rare subtype of adrenal tumors with challenging diagnosis and histoprognostic assessment. It is usually believed that oncocytic adrenocortical tumors have a more indolent clinical behavior than conventional adrenocortical tumors. As the Weiss score overestimates the malignancy of oncocytic adrenocortical tumors owing to intrinsic parameters, alternative scores have been proposed. The Lin-Weiss-Bisceglia score is currently recommended. We performed a large nationwide multicenter retrospective clinicopathologic study of oncocytic adrenocortical tumors...
June 19, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
Bryan Minh Tran, David James Roshan, Earl Abraham, Laura Y Wang, Natalia Garibotto, James Wykes, Peter Campbell, Ardalan Ebrahimi
BACKGROUND: Although the importance of tumor size in papillary thyroid cancer (PTC) is well established, there is no research to investigate whether age modifies the impact of tumor size, and conflicting evidence regarding optimal size thresholds for prognostic discrimination. We aimed to verify that tumor size is an independent prognostic factor in PTC, to investigate the impact of patient age, and to identify optimal size cut-offs for risk stratification using objective measures of model performance...
June 19, 2018: Thyroid: Official Journal of the American Thyroid Association
Xiaojuan Gao, Jia Li, Yaqi Wang, Shuai Liu, Baohong Yue
Recent studies show that Epstein-Barr virus (EBV) positivity might be related to adverse prognosis in patients with diffuse large B-cell lymphoma (DLBCL), but the results are still inconclusive. We conducted this meta-analysis to define the clinical value of EBV infection in DLBCL. All potential articles in PubMed, Web of Science, Medline, and Embase were retrieved. Using the random-effects or fixed-effect model, pooled hazard ratios (HRs) or relative risk (RR) with 95% confidence intervals (CIs) were used to calculate the correlation between EBER and prognosis and clinical features in DLBCL...
2018: PloS One
Siamak Yousefi, Taichi Kiwaki, Yuhui Zheng, Hiroki Suigara, Ryo Asaoka, Hiroshi Murata, Hans Lemij, Kenji Yamanishi
PURPOSE: Global indices of standard automated perimerty are insensitive to localized losses, while point-wise indices are sensitive but highly variable. Region-wise indices sit in between. This study introduces a machine-learning-based index for glaucoma progression detection that outperforms global, region-wise, and point-wise indices. DESIGN: Development and comparison of a prognostic index. METHOD: Visual fields from 2085 eyes of 1214 subjects were used to identify glaucoma progression patterns using machine learning...
June 16, 2018: American Journal of Ophthalmology
Anthony Ding, Robert V OʼToole, Renan Castillo, Brad Reahl, Ryan Montalvo, Jason W Nascone, Marcus F Sciadini, Anthony R Carlini, Theodore T Manson
OBJECTIVES: To identify the risk factors for early reoperation after operative fixation of acetabular fractures. DESIGN: Retrospective evaluation. SETTING: Level I Trauma Center. PATIENTS: Seven hundred ninety-one patients with displaced acetabular fractures treated with open reduction and internal fixation (ORIF) from 2006 to 2015. Average follow-up was 52 weeks. MAIN OUTCOME MEASURES: Early reoperation after acetabular ORIF, defined as secondary procedure for infection or revision within 3 years of initial operation...
July 2018: Journal of Orthopaedic Trauma
Akihiro Hosaka, Manabu Motoki, Masaaki Kato, Hiroko Sugai, Nobukazu Okubo
OBJECTIVE: Thoracic endovascular aortic repair (TEVAR) with supra-aortic debranching has recently been introduced as a treatment option for aortic arch disease. Although less invasive than open repair, TEVAR is associated with a risk of perioperative embolic stroke due to dislodgment of atherosclerotic plaque debris, especially in individuals with atheromatous degeneration of the aortic lumen. It is difficult to determine atheroma vulnerability, and there is no current method for predicting the risk of atheroembolism...
June 15, 2018: Journal of Vascular Surgery
Pasquale Scaramozzino, Alban Y Neziri, Ole K Andersen, Lars Arendt-Nielsen, Michele Curatolo
Aabstract Background and purpose Central hypersensitivity, defined as an increased excitability of the central nervous system, is considered as the main factor behind facilitation of central pain processes and is probably a very important factor in the induction and maintenance of chronic pain. Widespread hyposensitivity is less studied than hypersensitivity states, but recent work indicates that hypoesthesia may be present in chronic non-neuropathic pain conditions and could have negative prognostic value...
December 29, 2017: Scandinavian Journal of Pain
Hitomi Takada, Masayuki Kurosaki, Hiroyuki Nakanishi, Yuka Takahashi, Jun Itakura, Kaoru Tsuchiya, Yutaka Yasui, Nobuharu Tamaki, Kenta Takaura, Yasuyuki Komiyama, Mayu Higuchi, Youhei Kubota, Wann Wang, Mao Okada, Nobuyuki Enomoto, Namiki Izumi
BACKGROUND: The present study aimed to investigate the impact of pre-sarcopenia on the prognosis of patients with advanced hepatocellular carcinoma (HCC) treated with sorafenib. METHODS: We enrolled 214 patients (71 ± 10 years old; 166 men and 48 women; 90% Child-Pugh grade A and 10% Child-Pugh grade B) treated with sorafenib in our hospital from July 2009 to August 2016. The muscle volume was measured from CT images just before sorafenib administration using software (SliceOmatic)...
2018: PloS One
Hee Jung Kwon, Jung Eun Choi, Young Kyung Bae
Interleukin-13 receptor alpha 2 is one of the subunits of transmembrane receptor for interleukin-13. The aim of this study was to investigate the prognostic value of interleukin-13 receptor alpha 2 expression in invasive breast cancer. Interleukin-13 receptor alpha 2 expressions were assessed by immunohistochemistry in tissue microarrays of 1283 invasive breast cancer samples, and associations between these expressions and clinicopathological variables and clinical outcomes were investigated. Interleukin-13 receptor alpha 2 expression was observed in 138 (10...
June 2018: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
Moritz S Bischoff, K Meisenbacher, A S Peters, D Weber, T Bisdas, G Torsello, D Böckler
PURPOSE: To evaluate the significance of perioperative changes in ankle-brachial index (ABI) with regard to extremity-related outcome in non-diabetic patients with critical limb ischemia (CLI) following revascularization. METHODS: The study represents a subanalysis of the multicentric Registry of First-line Treatment in Patients with CLI (CRITISCH). After exclusion of diabetic patients, conservative cases, and primary major amputation, 563 of 1200 CRITISCH patients (mean age 74 ± 10...
June 17, 2018: Langenbeck's Archives of Surgery
Nicola Riccardo Pugliese, Iacopo Fabiani, Salvatore La Carrubba, Scipione Carerj, Lorenzo Conte, Paolo Colonna, Pio Caso, Frank Benedetto, Francesco Antonini-Canterin, Maria Francesca Romano, Rodolfo Citro, Vitantonio Di Bello
Introduction: Doppler echocardiography with early diastolic transmitral velocity (E)/early mitral annular diastolic velocity (E') ratio has been proposed as the best predictor for evaluating left ventricle (LV) filling pressure. A dimensionless index E/(E' × S') ratio (S' = systolic mitral annulus velocity) resulted in readily, reproducible, and reliable predictor of LV filling pressure. We assessed the prognostic impact of E/E' × S') in patients with asymptomatic heart failure (HF)...
April 2018: Journal of Cardiovascular Echography
I García-Talavera, J M Figueira-Gonçalves, N Gurbani, L Pérez-Méndez, A Pedrero-García
BACKGROUND: Exercise-induced desaturation in chronic obstructive pulmonary disease (COPD) frequently has prognostic implications. Desaturation within the first minute of the walk 6-minute walk test will probably also occur in daily life activities and translate into hypoxaemic respiratory failure at rest in later years. This study aimed at comparing these patients with those who desaturate after the first minute and determine potential markers. METHODS: We conducted a cross-sectional, retrospective study collecting data on respiratory function tests, cardiovascular comorbidity, body mass index, pack-year index, 6-minute walk test outcomes, BODE index, and Charlson comorbidity index...
June 14, 2018: Pulmonology
Huangming Hong, Xiaojie Fang, Zhao Wang, He Huang, Sio Teng Lam, Fangfang Li, Chen Peng, Ying Tian, Suxia Lin, Tongyu Lin
Angioimmunoblastic T-cell lymphoma (AITL) is a distinct subtype of peripheral T-cell lymphoma with unique clinical and pathological features. This study aim to design a prognostic model specifically for AITL, providing risk stratification in affected patients. A total of 115 newly diagnosed AITL patients were retrospectively analyzed. The estimated five-year overall survival (OS) rate for all patients was 45.4%. Multivariate analysis found prognostic factors for survival were bone marrow involvement, number of extranodal sites >1, and performance status >1...
June 18, 2018: Leukemia & Lymphoma
Bin-Bin Cai, Ke-Qing Shi, Peng Li, Bi-Cheng Chen, Liang Shi, Philip J Johnson, Paul Lai, Hidenori Toyoda, Meng-Tao Zhou
BACKGROUND: Because of the mutual influence of liver dysfunction and malignancy, overall survival (OS) is a composite clinical endpoint in hepatocellular carcinoma (HCC). We developed a nomogram integrating albumin-bilirubin (ALBI) grade, a new index of hepatic reserve, and tumor characteristics of HCC for predicting OS following curative liver resection. METHODS: The nomogram was built to estimate the probabilities of 1, 3, and 5-y OS based on training cohort of 709 HCC, which was validated in an international independent dataset...
June 14, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
M Cesari, C Franchi, L Cortesi, A Nobili, I Ardoino, P M Mannucci
BACKGROUND: Frailty is a state of increased vulnerability to stressors, associated to poor health outcomes. The aim of this study was to design and introduce a Frailty Index (FI; according to the age-related accumulation of deficit model) in a large cohort of hospitalized older persons, in order to benefit from its capacity to comprehensively weight the risk profile of the individual. METHODS: Patients aged 65 and older enrolled in the REPOSI register from 2010 to 2016 were considered in the present analyses...
June 12, 2018: European Journal of Internal Medicine
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