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https://www.readbyqxmd.com/read/29037006/microrna-150-5p-improves-risk-classification-for-mortality-within-90-days-after-acute-ischemic-stroke
#1
Natalie Scherrer, Francois Fays, Beat Mueller, Andreas Luft, Felix Fluri, Mirjam Christ-Crain, Yvan Devaux, Mira Katan
BACKGROUND AND PURPOSE: Micro ribonucleic acid-150-5p (miR-150-5p) regulates proinflammatory cytokines as well as vessel integrity. We evaluated the incremental prognostic value of logarithm (log) of miR-150-5p plasma levels after ischemic stroke. METHODS: In a prospective cohort study, levels of miR-150-5p were measured within 72 hours of symptom onset in 329 ischemic stroke patients. The outcome measures were unfavorable functional outcome (assessed by the modified Rankin Scale score >2) and mortality within 90 days...
September 2017: Journal of Stroke
https://www.readbyqxmd.com/read/29036563/loss-of-cd15-expression-in-clear-cell-renal-cell-carcinoma-is-correlated-with-worse-prognosis-in-chinese-patients
#2
Chen-Yan Wu, Jian-Ping Huo, Xin-Ke Zhang, Yi-Jun Zhang, Wan-Ming Hu, Ping Yang, Jia-Bin Lu, Zhi-Ling Zhang, Yun Cao
Purpose: To explore the role of CD15 expression in the prognosis of clear cell renal cell carcinoma (ccRCC) in Chinese patients. Methods: The study included 301 patients who had undergone surgery for localized ccRCC. All paraffin-embedded tumor sections were collected to make a set of tissue microarrays. CD15 expression was assessed by immunohistochemistry. The relationship between CD15 expression and survival parameters, clinicopathology features was assessed. Kaplan-Meier and Cox proportional hazards model were utilized to determine the correlation between CD15 expression and overall survival (OS)...
September 21, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29035456/circulating-mir-29b-and-mir-424-as-prognostic-markers-in-patients-with-acute-cerebral-infarction
#3
Yue-Zhan Zhang, Jun Wang, Feng Xu
BACKGROUND: Down-regulation of miR-29b and miR-424 have been observed in patients with acute cerebral infarction (ACI); however, the clinical significance of circulating miR-29b and miR-424 as prognostic markers still requires further investigation. METHODS: A total of 45 patients diagnosed with ACI and 45 healthy volunteers were enrolled in this study, and the clinical information of the patients were collected. The serum samples of the participants were collected and stored at -80°C...
October 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/29035431/prognostic-application-of-thoracic-aortic-calcium-scoring-for-adverse-clinical-outcome-risk-in-elderly-patients-with-left-ventricular-hypertrophy
#4
In Jeong Cho, Hyuk Jae Chang, Sang Eun Lee, Chi Young Shim, Geu Ru Hong, Namsik Chung
BACKGROUND AND OBJECTIVES: Left ventricular hypertrophy (LVH) is associated with poor cardiovascular outcomes. Heavy aortic calcification exacerbates arterial stiffness, which consequently heightens left ventricular (LV) afterload. We assessed the usefulness of aortic calcification for predicting adverse cardiovascular outcomes and to determine whether the relationship, if any, differed as a function of LVH. METHODS: The analytic sample was comprised of a total of 487 individuals 65 years of age or older...
September 18, 2017: Korean Circulation Journal
https://www.readbyqxmd.com/read/29035297/variability-in-strength-pain-and-disability-changes-in-response-to-an-isolated-lumbar-extension-resistance-training-intervention-in-participants-with-chronic-low-back-pain
#5
James Steele, James Fisher, Stewart Bruce-Low, Dave Smith, Neil Osborne, Dave Newell
Strengthening the lumbar extensor musculature is a common recommendation for chronic low back pain (CLBP). Although reported as effective, variability in response in CLBP populations is not well investigated. This study investigated variability in responsiveness to isolated lumbar extension (ILEX) resistance training in CLBP participants by retrospective analysis of three previous randomized controlled trials. Data from 77 participants were available for the intervention arms (males = 43, females = 34) 37 participants data (males = 20, females = 17) from the control arms...
October 16, 2017: Healthcare (Basel, Switzerland)
https://www.readbyqxmd.com/read/29034756/a-prediction-model-for-early-death-in-non-small-cell-lung-cancer-patients-following-curative-intent-chemoradiotherapy
#6
Arthur Jochems, Issam El-Naqa, Marc Kessler, Charles S Mayo, Shruti Jolly, Martha Matuszak, Corinne Faivre-Finn, Gareth Price, Lois Holloway, Shalini Vinod, Matthew Field, Mohamed Samir Barakat, David Thwaites, Dirk de Ruysscher, Andre Dekker, Philippe Lambin
BACKGROUND: Early death after a treatment can be seen as a therapeutic failure. Accurate prediction of patients at risk for early mortality is crucial to avoid unnecessary harm and reducing costs. The goal of our work is two-fold: first, to evaluate the performance of a previously published model for early death in our cohorts. Second, to develop a prognostic model for early death prediction following radiotherapy. MATERIAL AND METHODS: Patients with NSCLC treated with chemoradiotherapy or radiotherapy alone were included in this study...
October 14, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/29033675/considering-the-relationship-between-quantitative-parameters-and-prognostic-factors-in-breast-cancer-can-mean-standardized-uptake-value-be-an-alternative-to-maximum-standardized-uptake-value
#7
Reyhan Köroğlu, İsmail Köksal, Fikri Selçuk Şimşek, Fatma Gezer, Ersoy Kekilli, Bülent Ünal
It was aimed to investigate the correlation between maximum standardized uptake value (SUVmax), mean standardized uptake value (SUVmean), and retention index (RI), which represents the quantitative evaluation of the uptake of (18)F-fluoro-2-deoxy-D-glucose ((18)F-FDG) used in positron emission tomography (PET) and clinicopathologic as well as biologic prognostic factors. Forty-one women with breast cancer who were histopathologically diagnosed were included in this study. Neoadjuvant chemotherapy was applied to all patients before PET/computed tomography (CT)...
October 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29033673/automated-bone-scan-index-as-predictors-of-survival-in-prostate-cancer
#8
Joko Wiyanto, Rini Shintawati, Budi Darmawan, Basuki Hidayat, Achmad Hussein Sundawa Kartamihardja
Prostate cancer (PCa) is the second most diagnosed cancer in men. Early diagnosis and right management of PCa is critical to reducing deaths; the life expectancy is the main factors to be considered in the management of PCa. Among patients who die from PCa, the incidence of skeletal involvement appears to be >85%. Bone scan (BS) is the most common method for monitoring bone metastases in patients with PCa. The extent of bone metastasis was also associated with patient survival until now there is no clinically useful technique for measuring bone tumors and includes this information in the risk assessment...
October 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29033591/clinicopathological-features-and-prognoses-in-younger-and-older-patients-with-gastric-cancer
#9
Shubin Song, Chunfeng Li, Sen Li, Xiliang Cong, Yingwei Xue
BACKGROUND AND OBJECTIVES: Patients of different ages with gastric cancer (GC) have different clinicopathological features and prognoses. The results for different crowds are limited and controversial. The aim of this study was to investigate the differences in clinicopathological features and prognoses between younger and older GC patients. METHODS: From January 2007 to December 2011, a consecutive total of 112 GC patients under 41 years old and 358 GC patients over 69 years old who underwent gastrectomy for GC were recruited for this study...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29033181/pathobiology-of-her-2-positive-small-invasive-t1a-b-breast-cancer-a-wolf-in-sheep-s-clothing
#10
Joško Bezić, Ivana Šamija Projić, Petar Projić, Kristina Meljanac Salopek, Piero Marin Živković, Joško Božić, Snježana Tomić
Small invasive breast cancers (cancers with maximum diameter <1cm, T1a,b) become more prevalent form of breast cancer as a result of the introduction of breast cancer mammographic screening programs. Although associated with an excellent prognosis, T1a,b breast cancers are heterogeneous group of tumors with prognostically unfavorable subset of cases, primarily those with axillary lymph node metastases. To determine if the HER2 overexpression is associated with the prognostically unfavorable traditional clinicopathological features in this group of breast cancers, clinicopathological features (age, tumor size, histological type, histological grade, nodal status, hormone receptor status, proliferation index, lymphovascular invasion, ploidy) of 38 HER2 positive T1a,b cancers were compared with those of the control group consisting of 315 HER2 negative T1a,b cancers...
October 9, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/29032728/estrogen-receptor-beta-expression-and-prognosis-of-diffuse-large-b-cell-lymphoma
#11
Saruta Faknuam, Thamathorn Assanasen, Preecha Ruangvejvorachai, Punchong Hanvivadhanakul, Tanin Intragumtornchai, Ponlapat Rojnuckarin
OBJECTIVES: Estrogen receptor beta (ERβ)-selective agonists inhibited B cell lymphoma growth in animal models. However, a recent study found that higher ERβ expression in tissue from diffuse large B cell lymphoma (DLBCL) patients indicated a poorer survival. This study aimed to determine the ERβ expression in DLBCL tissue using immunohistochemistry and correlate with clinical outcomes. METHODS: Diagnostic tissues from newly diagnosed adult DLBCL patients treated with Rituximab-Cyclophosphamide/Doxorubicin/Vincristine/Prednisolone were counted for ERβ1-expressing cells...
October 15, 2017: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/29031827/development-of-a-surgical-site-infection-prediction-model-in-orthopaedic-trauma-the-denver-health-model
#12
Sara M Reese, Bryan Knepper, Heather L Young, Cyril Mauffrey
BACKGROUND: The CDC's National Healthcare Safety Network's (NHSN) current risk adjustment model for surgical site infections (SSI) following open reduction internal fixation (ORIF) of long bone fractures is a suboptimal predictor of risk. We hypothesized that by including variables known to be associated with SSI following ORIF, we would develop a model that would increase the accuracy and predictability of SSI risk. METHODS: Patients who underwent ORIF of a long bone between January 1, 2012 and December 31, 2014 were included in the study (n=1543)...
October 9, 2017: Injury
https://www.readbyqxmd.com/read/29031515/association-of-antidementia-drugs-and-mortality-in-community-dwelling-frail-older-patients-with-dementia-the-role-of-mortality-risk-assessment
#13
Alberto Pilotto, Maria Cristina Polidori, Nicola Veronese, Francesco Panza, Rosa Arboretti Giancristofaro, Andrea Pilotto, Julia Daragjati, Eleonora Carrozzo, Camilla Prete, Pietro Gallina, Alessandro Padovani, Stefania Maggi
OBJECTIVE: To evaluate whether treatment with antidementia drugs is associated with reduced mortality in older patients with different mortality risk at baseline. DESIGN: Retrospective. SETTING: Community-dwelling. PARTICIPANTS: A total of 6818 older people who underwent a Standardized Multidimensional Assessment Schedule for Adults and Aged Persons (SVaMA) evaluation to determine accessibility to homecare services or nursing home admission from 2005 to 2013 in the Padova Health District, Italy were included...
October 11, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/29030164/renal-function-as-a-cofactor-for-risk-stratification-and-short-term-outcome-in-acute-pulmonary-embolism
#14
Karsten Keller, Johannes Beule, Jörn Oliver Balzer, Wolfgang Dippold
BACKGROUND: In addition to right ventricular dysfunction (RVD) and myocardial injury, impaired renal function is connected with poorer prognosis in pulmonary embolism (PE). We aimed to investigate renal function as a cofactor for risk stratification in PE. METHODS: Data from 182 patients with PE, treated between May2006 and June2011, were analysed retrospectively. PE patients with elevated creatinine were compared with those with normal values. Logistic regression models were calculated to investigate associations between creatinine and myocardial necrosis, RVD and in-hospital death...
October 10, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/29029780/risk-factors-for-surgical-site-infection-after-stoma-closure-comparison-between-pursestring-wound-closure-and-conventional-linear-wound-closure-propensity-score-matching-analysis
#15
Masashi Yamamoto, Keitaro Tanaka, Shinsuke Masubuchi, Masatsugu Ishii, Hiroki Hamamoto, Shigenori Suzuki, Yasuhiko Ueda, Junji Okuda, Kazuhisa Uchiyama
PURPOSE: Stoma closure has been associated with a high rate of surgical site infection (SSI) and the optimal skin closure method is still controversial. The aim of this study was to compare the short-term and long-term outcomes between the conventional linear closure (CC) and the persestring closure (PC) using propensity score matching analysis. METHODS: We analysed the data of 360 patients who underwent stoma closure with CC or PC between January 2000 and December 2014...
October 6, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/29029493/systemic-immune-inflammation-index-predicts-the-clinical-outcome-in-patients-with-nasopharyngeal-carcinoma-a-propensity-score-matched-analysis
#16
Wenjie Jiang, Yuan Chen, Jin Huang, Dan Xi, Jun Chen, Yingjie Shao, Guoping Xu, Wenming Ying, Jun Wei, Junjun Chen, Zhonghua Ning, Wendong Gu, Honglei Pei
Systemic immune-inflammation index (SII), based on peripheral lymphocyte, neutrophil, and platelet counts, was recently investigated as a prognostic marker in several tumors. However, SII has not been reported in nasopharyngeal carcinoma (NPC). We evaluated the prognostic value of the SII in 327 patients with NPC. Univariate and multivariate analyses were calculated by the Cox proportional hazards regression model. The time-dependent receiver operating characteristics (ROC) curve was used to compare the discrimination ability for OS...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29029447/the-association-between-renal-sinus-fat-area-and-the-progression-free-survival-in-chinese-non-metastatic-clear-cell-renal-cell-carcinoma-patients
#17
Haichao Huang, Shi Chen, Wei Yu, Zirong Ye, Wei Li, Jinchun Xing, Xiurong Wu
In this retrospective study, we evaluated the association between renal sinus fat area (RSFA) and survival in 268 Chinese non-metastatic clear-cell renal cell carcinoma (ccRCC) patients. Patients with high RSFA exhibited better progression-free survival than those with low RSFA in both univariable (HR: 0.240; 95% CI: 0.119-0.482; p < 0.001) and multivariable (HR: 0.432; 95% CI: 0.369-2.749; p = 0.027) analyses. A propensity-score matched (PSM) analysis using Kaplan-Meier curves confirmed our findings (log-rank test; p = 0...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29029412/the-value-of-phosphohistone-h3-as-a-proliferation-marker-for-evaluating-invasive-breast-cancers-a-comparative-study-with-ki67
#18
Ji-Ye Kim, Hyang Sook Jeong, Taek Chung, Moonsik Kim, Ji Hee Lee, Woo Hee Jung, Ja Seung Koo
BACKGROUND: Established measurements of proliferation in breast cancer are Ki67 and mitotic-activity-index (MAI), with problems in reproducibility and prognostic accuracy. Phosphohistone H3 (PHH3), a relatively novel IHC marker is specific for mitosis with good reproducibility. We hypothesized that PHH3 would be more reproducible and better represent proliferation than Ki67. RESULTS: PHH3 identified easily-missed mitosis by MAI, as demonstrated by upgrading M grade at diagnosis (n = 29/218, evenly distributed)...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29027629/combined-analysis-of-the-preoperative-and-postoperative-prognostic-nutritional-index-offers-a-precise-predictor-of-the-prognosis-of-patients-with-gastric-cancer
#19
Yuki Murakami, Hiroaki Saito, Yusuke Kono, Yuji Shishido, Hirohiko Kuroda, Tomoyuki Matsunaga, Yoji Fukumoto, Tomohiro Osaki, Keigo Ashida, Yoshiyuki Fujiwara
PURPOSE: The prognostic nutritional index (PNI) is considered useful for predicting the prognosis of patients with gastric cancer (GC). This retrospective study investigated the relationship between both the pre- and postoperative PNI and the prognosis of GC patients. METHODS: The subjects of this study were 254 patients who underwent curative surgery for histopathologically diagnosed GC. RESULTS: Patients were divided according to their pre- and postoperative PNI as follows: preoperative PNI of ≥ 52 (pre-PNI(High)), preoperative PNI of < 52 (pre-PNI(Low)), postoperative PNI of ≥ 49 (post-PNI(High)), and postoperative PNI of < 49 (pre-PNI(Low))...
October 12, 2017: Surgery Today
https://www.readbyqxmd.com/read/29027497/comparative-evaluation-of-treatment-patterns-and-healthcare-utilization-of-newly-diagnosed-rheumatoid-arthritis-patients-by-anti-cyclic-citrullinated-peptide-antibody-status
#20
Lois Lamerato, Kylie Matthews, Kwanza Price, Alan Szymialis, Michael Eaddy, Augustina Ogbonnaya, Huai-Che Shih, Harris Ahmad
BACKGROUND: Anti-cyclic citrullinated peptide (CCP) antibody positivity is an established diagnostic factor for severe disease activity and joint damage and a prognostic factor for aggressive disease in rheumatoid arthritis (RA). OBJECTIVE: To compare RA-related treatment, healthcare utilization, and joint erosion between anti-CCP-positive and anti-CCP-negative RA patients. METHODS: Newly diagnosed RA patients were identified from the Henry Ford Health System database between 1/1/2009 and 12/31/2014; the date of the first RA diagnosis within the study period was the index date...
October 13, 2017: Journal of Medical Economics
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