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Forensic Pathology

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https://www.readbyqxmd.com/read/29777982/documentation-and-analysis-of-traumatic-injuries-in-clinical-forensic-medicine-involving-structured-light-three-dimensional-surface-scanning-versus-photography
#1
Awatif Shamata, Tim Thompson
Non-contact three-dimensional (3D) surface scanning has been applied in forensic medicine and has been shown to mitigate shortcoming of traditional documentation methods. The aim of this paper is to assess the efficiency of structured light 3D surface scanning in recording traumatic injuries of live cases in clinical forensic medicine. The work was conducted in Medico-Legal Centre in Benghazi, Libya. A structured light 3D surface scanner and ordinary digital camera with close-up lens were used to record the injuries and to have 3D and two-dimensional (2D) documents of the same traumas...
May 10, 2018: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/29760352/time-dependent-changes-in-local-and-serum-levels-of-inflammatory-cytokines-as-markers-for-incised-wound-aging-of-skeletal-muscles
#2
Mohammed Hassan Gaballah, Tetsuya Horita, Masataka Takamiya, Keisuke Yokoji, Mamiko Fukuta, Hideaki Kato, Yasuhiro Aoki
Wound age estimation is an important research field in forensic pathology. The expression levels of cytokines in the incised skeletal muscle were analyzed using a mouse model to explore the applicability for wound aging. A 5-mm long incisional wound was made at the biceps femoris muscle, and the muscle and serum were sampled at 6, 12, 24 and 48 hours after injury. Using a multiplex bead-based immunoassay, we measured the tissue levels of nine cytokines (IL-1β, IL-6, IL-7, CCL2, CCL3, CCL4, CXCL1, CXCL2, and CXCL10), which are all involved in the pathways of inflammatory response and tissue injury...
2018: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29752198/age-estimation-of-hispanic-children-using-the-london-atlas
#3
David McCloe, Ian Marion, Marcio A da Fonseca, Michael Colvard, Sakher AlQahtani
PURPOSE: To test the accuracy of the London Atlas for age estimation of Hispanic children and to determine if there is any difference in age accuracy between Hispanic males and females. METHODS: The London Atlas was used to estimate age from panoramic radiographs of 17 males and 17 females for each year of age from six to 15.99 years, using the electronic patient database of a dental school. Exclusion criteria included gross pathology, hypodontia, hyperdontia, and previous orthodontic treatment...
April 16, 2018: Forensic Science International
https://www.readbyqxmd.com/read/29732941/measurement-of-cerebral-biomarkers-proving-traumatic-brain-injuries-in-post-mortem-body-fluids
#4
Benjamin Ondruschka, Monique Sieber, Holger Kirsten, Heike Franke, Jan Dressler
Until now, it is impossible to identify a fatal traumatic brain injury (TBI) before post-mortem radiological investigations or an autopsy take place. It would be preferable to have an additional diagnostic tool like post-mortem biochemistry to get greater insight into the pathological pathways and survival times after sustaining TBI. Cerebrospinal fluid (CSF) and serum samples of 84 autopsy cases were collected from forensic autopsies with post-mortem intervals (PMI) of up to 148 h. The cases were categorized into a fatal TBI case group (n=42) and non-TBI controls (n=42)...
May 5, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29730384/the-expression-of-il10ra-in-colorectal-cancer-and-its-correlation-with-the-proliferation-index-and-the-clinical-stage-of-the-disease
#5
Łukasz Zadka, Michał J Kulus, Krzysztof Kurnol, Aleksandra Piotrowska, Natalia Glatzel-Plucińska, Tomasz Jurek, Magdalena Czuba, Aleksandra Nowak, Mariusz Chabowski, Dariusz Janczak, Piotr Dzięgiel
INTRODUCTION: Despite the widely described role of IL10 in immune response regulation during carcinogenesis, there is no established model describing the role of its receptor. The aim of this study is to elucidate the relationship between the subunit alpha of IL10 receptor (IL10RA) in the pathogenesis of colorectal cancer (CRC). METHODS: The study was conducted on archived paraffin blocks of 125 CRC patients, from which tissue microarrays (TMA) were made. These were subsequently used for immunohistochemistry to assess the expression of IL10RA, IL10, phosphorylated STAT3 (pSTAT3) and the Ki67 proliferation index...
May 3, 2018: Cytokine
https://www.readbyqxmd.com/read/29725812/postmortem-cardiac-magnetic-resonance-in-sudden-cardiac-death
#6
REVIEW
Benedetta Guidi, Giovanni Donato Aquaro, Marco Gesi, Michele Emdin, Marco Di Paolo
Postmortem imaging is increasingly used in forensic practice as good complementary tool to conventional autopsy investigations. Over the last decade, postmortem cardiac magnetic resonance (PMCMR) imaging was introduced in forensic investigations of natural deaths related to cardiovascular diseases, which represent the most common causes of death in developed countries. Postmortem CMR application has yielded interesting results in ischemic myocardium injury investigations and in visualizing other pathological findings in the heart...
May 4, 2018: Heart Failure Reviews
https://www.readbyqxmd.com/read/29722472/fulminant-group-a-streptococcal-infection-without-gangrene-in-the-extremities-analysis-of-five-autopsy-cases
#7
Shu Kato, Motoi Yanazaki, Kino Hayashi, Fumiko Satoh, Ichiro Isobe, Yutaka Tsutsumi
Five autopsy cases of fulminant group A streptococcal infection without gangrene in the extremities are presented. Clinical course of the fulminant illness was short (2-4 days). One pathological autopsy case was aged (86-years-old), and hemorrhagic cystitis was observed. The other four forensic autopsy cases were young (24-38 years-old) with the mean age of 32, and the primary infective lesions were located in the postpartum endometrium, tonsil and bronchus (2 cases). Systemic coccal dissemination with poor neutrophilic reaction was seen in two of five cases...
May 3, 2018: Pathology International
https://www.readbyqxmd.com/read/29713294/characteristics-and-pathways-of-long-stay-patients-in-high-and-medium-secure-settings-in-england-a-secondary-publication-from-a-large-mixed-methods-study
#8
Birgit A Völlm, Rachel Edworthy, Nick Huband, Emily Talbot, Shazmin Majid, Jessica Holley, Vivek Furtado, Tim Weaver, Ruth McDonald, Conor Duggan
Background: Many patients experience extended stays within forensic care, but the characteristics of long-stay patients are poorly understood. Aims: To describe the characteristics of long-stay patients in high and medium secure settings in England. Method: Detailed file reviews provided clinical, offending and risk data for a large representative sample of 401 forensic patients from 2 of the 3 high secure settings and from 23 of the 57 medium secure settings in England on 1 April 2013. The threshold for long-stay status was defined as 5 years in medium secure care or 10 years in high secure care, or 15 years in a combination of high and medium secure settings...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29704727/how-do-skeletons-with-hiv-present-a-study-on-the-identified-cal-milano-cemetery-skeletal-collection
#9
Lucie Biehler-Gomez, Antonio Cabrini, Danilo De Angelis, Cristina Cattaneo
With the Human Immunodeficiency Virus (HIV) infection and Acquired Immune Deficiency Syndrome (AIDS) pandemic, the study of HIV/AIDS on bones has become of pivotal interest for research in bone pathologies, forensic applications (especially in the matter of identification when confronted to antemortem data) and medical purposes. In this paper, we document and discuss the macroscopic lesions found on the skeletons of nine individuals with known HIV, including four with known AIDS, coming from the identified CAL Milano Cemetery Skeletal Collection...
April 24, 2018: Legal Medicine
https://www.readbyqxmd.com/read/29704413/difficulties-to-differentiate-mood-disorders-co-occurring-with-compulsive-gambling-discussion-based-on-a-case-study
#10
REVIEW
Anna Pilszyk, Andrzej Silczuk, Bogusław Habrat, Janusz Heitzman
Contemporary literature does not take a clear position on the issue of determining civil and criminal liability of persons diagnosed with pathological gambling, and all the more so in case of possible comorbidity of or interference with other mental disorders. Diagnostic difficulties are demonstrated by a clinical picture of a patient with problem gambling who underwent forensic and psychiatric assessments to evaluate the process of making informed (and independent) decisions in view of numerous concluded civil law (mainly financial) agreements...
February 28, 2018: Psychiatria Polska
https://www.readbyqxmd.com/read/29703624/a-modern-documented-italian-identified-skeletal-collection-of-2127-skeletons-the-cal-milano-cemetery-skeletal-collection
#11
Cristina Cattaneo, Debora Mazzarelli, Annalisa Cappella, Elisa Castoldi, Mirko Mattia, Pasquale Poppa, Danilo De Angelis, Antonio Vitello, Lucie Biehler-Gomez
The CAL Milano Cemetery Skeletal Collection is a modern and continuously growing identified osteological collection of 2127 skeletons under study in the Laboratorio di Antropologia e Odontologia Forense (LABANOF) in the Department of Biomedical Sciences for Health of the University of Milan (Italy), and part of the Collezione Antropologica LABANOF (CAL). The collection presents individuals of both sexes and of all age groups with a high representation of the elderly and an interesting sample of infants. Each individual is associated with a documentation that includes sex, age-at-death, dates of birth and death, and a death certificate that specifies the exact cause of death and the chain of events that led to it (related pathological conditions or traumatic events)...
March 31, 2018: Forensic Science International
https://www.readbyqxmd.com/read/29685008/medicamentous-thrombolysis-disguises-pulmonary-thromboembolism-as-a-cause-of-death
#12
I Šoša, A Ferencic, V Stemberga, G Zamolo, S Arbanas, I Dasek, M Perkovic, D Cuculic
We report the case of a 31-year-old female who was admitted to the emergency department with symptoms of cardiac arrest and ultimately died in spite of enormous resuscitation efforts. During resuscitation, pulmonary embolism was considered as a possible non-cardiac cause of cardiac arrest, and following its extremely unfavorable prognosis, the fatal outcome was not so surprising. However, since acute pulmonary emboli obstructing blood flow to a lobe or multiple lung segments was suspected, alteplase was indicated and administered...
March 2018: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29684943/the-diagnostic-implications-of-two-cases-of-known-rheumatoid-arthritis-from-the-cal-milano-cemetery-skeletal-collection
#13
Lucie Biehler-Gomez, Cristina Cattaneo
Rheumatoid arthritis (RA) is the most common erosive arthropathy and is of particular interest to forensic sciences. However, its diagnosis on bones remains challenging. We examined two skeletons from the CAL Milano Cemetery Skeletal Collection diagnosed with the pathology during life, to test the validity of the diagnostic criteria on bones. The first showed typical lesions of RA described in the literature. The second exhibited secondary osteoarthrosis, suggesting long-standing RA. A differential diagnosis including all four seronegative spondyloarthropathies, erosive osteoarthritis, gout and neuropathic arthropathy was also considered...
April 23, 2018: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/29679215/diagnostic-role-of-serum-tryptase-in-anaphylactic-deaths-in-forensic-medicine-a-systematic-review-and-meta-analysis
#14
REVIEW
Kai-Jian Sun, Jie-Tao He, Hong-Yan Huang, Ye Xue, Xiao-Li Xie, Qi Wang
Postmortem diagnosis of sudden death due to anaphylaxis can be very difficult due to the non-specific pathological findings in forensic practice. Postmortem serum tryptase has been used as an indicator of possible ante-mortem anaphylaxis. Though many previous studies have been conducted to explore the diagnostic significance of serum tryptase for lethal anaphylaxis, inconsistent results were documented. In this study, we made a retrospective study and presented a systematic review and meta-analysis that aims to summarize the diagnostic significance of postmortem serum tryptase in the deceased with and without anaphylactic shock and to calculate a cutoff value for future reference in the identification of deaths due to anaphylactic shock...
April 21, 2018: Forensic Science, Medicine, and Pathology
https://www.readbyqxmd.com/read/29678777/a-10-year-review-of-sudden-death-during-sporting-activities
#15
Mark Dennis, Alexander Elder, Christopher Semsarian, John Orchard, Isabel Brouwer, Rajesh Puranik
BACKGROUND: Sudden death during sport is a rare but devastating event. Previous research has mostly focused on sudden deaths in young competitive athletes. OBJECTIVE: To characterise the demographics and aetiology of sudden cardiac death (SCD) during sport in Australia. METHODS: All autopsies conducted at our forensic medicine facility between the years 2006-2015 (inclusive) were reviewed. Sporting related deaths amongst those 7-65 years of age were identified...
April 17, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29667640/-the-efficiency-of-the-application-of-the-modern-computed-technologies-in-the-clinical-practice-and-the-prospects-for-the-further-use-of-the-biomechanical-3d-models-in-forensic-medicine
#16
I Yu Makarov, A V Svetlakov, A V Sotin, S V Shigeev, A A Gusarov, S A Smirenin, V V Emelin, V B Stragis, V A Fetisov
To-day, the computer-assisted 3D-technologies for the mathematical simulation of the engineering facilities are extensively used for the purpose of technical calculations in all branches of industry and building. The positive experience gained with the application of the 3D-models finds wide application in the joined investigations on the topical problems of the prosthetic and surgical treatment of bones, teeth, joints, cardiac valves, blood vessels, etc. The objective of the present study was the analysis of the positive experience with the involvement of the specialists in the design and practical application of 3D-models for the solution of problems facing the medical prosthetics and the management of various pathological conditions...
2018: Sudebno-meditsinskaia Ekspertiza
https://www.readbyqxmd.com/read/29667634/-the-dynamics-of-the-dimensional-characteristics-of-the-sella-turcica-in-the-subjects-above-20-years-of-age
#17
Yu I Pigolkin, M D Ametrin, G V Zolotenkova
The objective of the present study was to determine the biological age of the unidentified dead subjects based on the morphometric characteristics of the sella turcica in comparison with other methods available for the purpose in order to narrow the range of the alleged ages of the human remains being examined. The parameters of the sella turcica were measured in the corpses immediately after cephalotomy provided no pathological changes could be identified in the sellar region. A total of 86 skulls of the Caucasoid subjects representing the Eastern-Slavic group at the age varying from 22 to 87 years were available for the examination...
2018: Sudebno-meditsinskaia Ekspertiza
https://www.readbyqxmd.com/read/29653319/analysis-of-fatal-accidents-with-tractors-in-the-centre-of-portugal-ten-years-analysis
#18
Soraia M Antunes, Cristina Cordeiro, Helena M Teixeira
Tractors have been described as one of the deadliest farming implements concerning agricultural activity. In Portugal, the scientific investigations about this problem are practically non-existent, with only statistical studies performed by entities related to road traffic safety, not in accordance to the study now performed, pinpointing the possibility of an underreporting of these accidents. This work aims to characterize the fatal tractor accidents in Portugal, autopsied at the Forensic Pathology Department of the Centre Branch of the National Institute of Legal Medicine and Forensic Sciences of Portugal, analysing several variables: gender, age, occupation, survival time, the victim position in the tractor, cause of death, toxicological and histological exams, year/month/day of the week, type of agricultural machine, existence of rollover protective structures (ROPS), type of accident, ground conditions, circumstantial information and geographic distribution of the accidents...
April 6, 2018: Forensic Science International
https://www.readbyqxmd.com/read/29649258/clinician-ratings-of-the-comprehensive-assessment-of-psychopathic-personality-capp-in-a-representative-sample-of-spanish-prison-inmates-new-validity-evidence
#19
Gerardo Flórez, Ventura Ferrer, Luis S García, María R Crespo, Manuel Pérez, Pilar A Saíz, David J Cooke
The Comprehensive Assessment of Psychopathic Personality (CAPP) is a concept map of psychopathic personality disorder (PPD). The CAPP- Institutional Rating Scale (IRS) is a tool designed to assess CAPP symptoms in institutional settings. The CAPP contains 33 personality traits organized in six domains: attachment, behavioural, cognitive, dominance, emotional and self. Until now, much of the CAPP research has been conducted out of clinical, forensic and correctional settings using self-ratings. In the current study, the psychometric properties and construct validity of the CAPP-IRS were evaluated in a non-convenience sample of 204 Spanish convicts...
2018: PloS One
https://www.readbyqxmd.com/read/29649020/autologous-bone-flap-resorption-years-after-subtemporal-craniotomy
#20
John Oladapo Obafunwa, Emily Hammerl, David Jaskierny, Livia Taylor, Lynette Russell, Karl Reinhard
In Spring of 2012, the partially undressed and skeletonized remains of a homeless adult Hispanic male was found in a fairly open wooded area in Nebraska. The remains showed evidence of extensive pathologies, which included healed traumas and surgeries. Examination of the decedent's medical records revealed that he had a history of kidney and liver problems, alcohol abuse, several traumas including a major head injury that necessitated a craniotomy, and radiological features of neurocysticercosis. The autologous bone flap, which was replaced after the craniotomy, had resorbed significantly away from the edges of the injury...
April 11, 2018: American Journal of Forensic Medicine and Pathology
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