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Forensic Pathology

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https://www.readbyqxmd.com/read/29154002/forensic-evaluation-of-str-typing-reliability-in-lung-cancer
#1
Peng Zhang, Ying Zhu, Yongguo Li, Shisheng Zhu, Ruoxiang Ma, Minzhu Zhao, Jianbo Li
Short tandem repeats (STR) analysis is the gold standard method in the forensics field for personal identification and paternity testing. In cancerous tissues, STR markers are gaining attention, with some studies showing increased instability. Lung cancer, which is one of the most commonmalignancies, has become the most lethal among all cancers. In certain situations, lung cancer tissues may be the only resource available for forensic analysis. Therefore, evaluating the reliability of STR markers in lung cancer tissues is required to avoid false exclusions...
November 11, 2017: Legal Medicine
https://www.readbyqxmd.com/read/29145187/diogenes-syndrome
#2
Frédéric Assal
Diogenes syndrome (DS) is not a specific disease but a real neurobehavioral syndrome, characterized by severe domestic squalor, pathological hoarding, lack of insight into the condition, and no need for help. DS can be secondary when associated to psychosis or bipolar disorder, or primary when it occurs as a single entity, usually in the elderly. DS is a clinically complex transnosographic syndrome for which multidimensional approaches need to be considered: medical, psychiatric, neurological, social, scientific, and ethical...
2018: Frontiers of Neurology and Neuroscience
https://www.readbyqxmd.com/read/29140802/characterization-with-scanning-electron-microscopy-energy-dispersive-x-ray-spectrometry-of-microtraces-from-the-ligature-mean-in-hanging-mechanical-asphyxia-a-series-of-forensic-cases
#3
Francesca Maghin, Salvatore Ambrogio Andreola, Michele Boracchi, Guendalina Gentile, Francesca Maciocco, Riccardo Zoja
The authors applied scanning electron microscopy with energy-dispersive x-ray spectrometry to the furrow derived from hanging means. The study was conducted with the purpose to detect possible extraneous microtraces, deriving from the ligature, that could have had an interaction with the cutaneous biological matrix, thanks to a transfert mechanism, in the proximities of the lesion.Fifteen cutaneous samples of the furrow and an equal number of fragments of graphite tape, directly positioned on the lesion produced by the ligature mean and used as a "conductor" of possible traces, were analyzed using scanning electron microscopy with energy-dispersive x-ray spectrometry...
November 15, 2017: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/29127893/traumatic-fatal-aortic-rupture-in-motorcycle-drivers
#4
Guido Pelletti, Giovanni Cecchetto, Alessia Viero, Maria De Matteis, Guido Viel, Massimo Montisci
Traumatic fatal aortic rupture (FAR) is a common finding in victims of motor vehicle crashes (MVC), but its aetiology and mechanisms of production remain an issue of major concern, above all in motorcyclists. This study reports a series of cases obtained from a retrospective analysis of traumatic FARs occurring in motorcycle drivers, with the aim of defining the injury patterns and correlating them with the mechanisms of FAR production. Circumstantial, autopsy and histology data were collected through a retrospective analysis of post mortem examinations performed at the Institute of Legal Medicine of the University of Padova between 2014 and 2016...
November 6, 2017: Forensic Science International
https://www.readbyqxmd.com/read/29125952/getting-to-the-core-of-medicine-developing-undergraduate-forensic-medicine-and-pathology-teaching
#5
Richard Martin Jones
Teaching and learning of forensic medicine and pathology in the undergraduate medical curriculum has been in decline for decades in the UK, and yet graduates are expected to be able to recognise, and protect, those who are most vulnerable in society - i.e. at risk of abuse or neglect - a matter highly relevant to the role of the forensic medical practitioner. When Cardiff University School of Medicine created a new 'learner-centred' undergraduate curriculum, championing case-based discussion in small groups, and earlier clinical contact, residual teaching on 'the pathology of trauma' disappeared...
October 16, 2017: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/29118310/manifestation-of-coronary-atherosclerosis-in-klang-valley-malaysia-an-autopsy-study
#6
Razuin Rahimi, Mansharan Kaur Chainchel Singh, Norizal Mohd Noor, Effat Omar, Shahidan Md Noor, Mohd Shah Mahmood, Nurliza Abdullah, Hapizah Mohd Nawawi
AIMS: The present study aimed to determine the epidemiological aspects of medico-legal autopsies and manifestation of coronary atherosclerosis. METHODS: This was a cross sectional study involving 222 cases recruited from National Institute of Forensic Medicine (NIFM) Hospital Kuala Lumpur (HKL) and Department of Forensic Medicine Hospital Sungai Buloh (HSgB) for a period of 15 months, from December 2012 to April 2014. Sociodemographic and autopsy findings, including the cause and manner of death were documented...
November 8, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29101907/differences-between-postmortem-ct-and-autopsy-in-death-investigation-of-cervical-spine-injuries
#7
Yohsuke Makino, Hajime Yokota, Eiji Nakatani, Daisuke Yajima, Go Inokuchi, Ayumi Motomura, Fumiko Chiba, Suguru Torimitsu, Takashi Uno, Hirotaro Iwase
OBJECTIVES: To clarify the differences between postmortem CT (PMCT) and autopsy findings in the postmortem detection of cervical spine injuries (CSIs). MATERIALS AND METHODS: Our department's forensic pathology database was searched for CSI cases. In each case, the autopsy data and radiologists' interpretations were reviewed for the presence of bone fractures and intervertebral injuries. RESULTS: The study included 42 cases. For both bone fractures and intervertebral injuries, no substantial concordance between PMCT and autopsy findings was observed (McNemar's test: p<0...
October 28, 2017: Forensic Science International
https://www.readbyqxmd.com/read/29100084/profiling-of-short-tandem-repeat-disease-alleles-in-12-632-human-whole-genomes
#8
Haibao Tang, Ewen F Kirkness, Christoph Lippert, William H Biggs, Martin Fabani, Ernesto Guzman, Smriti Ramakrishnan, Victor Lavrenko, Boyko Kakaradov, Claire Hou, Barry Hicks, David Heckerman, Franz J Och, C Thomas Caskey, J Craig Venter, Amalio Telenti
Short tandem repeats (STRs) are hyper-mutable sequences in the human genome. They are often used in forensics and population genetics and are also the underlying cause of many genetic diseases. There are challenges associated with accurately determining the length polymorphism of STR loci in the genome by next-generation sequencing (NGS). In particular, accurate detection of pathological STR expansion is limited by the sequence read length during whole-genome analysis. We developed TREDPARSE, a software package that incorporates various cues from read alignment and paired-end distance distribution, as well as a sequence stutter model, in a probabilistic framework to infer repeat sizes for genetic loci, and we used this software to infer repeat sizes for 30 known disease loci...
November 2, 2017: American Journal of Human Genetics
https://www.readbyqxmd.com/read/29023687/a-guide-for-effective-anatomical-vascularization-studies-useful-ex%C3%A2-vivo-methods-for-both-ct-and-mri-imaging-before-dissection
#9
Yohann Renard, Gabriela Hossu, Bailiang Chen, Marine Krebs, Marc Labrousse, Manuela Perez
The objective of this study was to develop a simple and useful injection protocol for imaging cadaveric vascularization and dissection. Mixtures of contrast agent and cast product should provide adequate contrast for two types of ex vivo imaging (MRI and CT) and should harden to allow gross dissection of the injected structures. We tested the most popular contrast agents and cast products, and selected the optimal mixture composition based on their availability and ease of use. All mixtures were first tested in vitro to adjust dilution parameters of each contrast agent and to fine-tune MR imaging acquisition sequences...
October 11, 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/29016939/molecular-autopsy-of-sudden-unexplained-deaths-reveals-genetic-predispositions-for-cardiac-diseases-among-young-forensic-cases
#10
Nicole Hellenthal, Anna Gaertner-Rommel, Bärbel Klauke, Lech Paluszkiewicz, Markus Stuhr, Thoralf Kerner, Martin Farr, Klaus Püschel, Hendrik Milting
Aims: Coronary artery disease accounts for the majority of sudden cardiac deaths (SCD) in the older population whereas cardiomyopathies and arrhythmogenic abnormalities predominate in younger SCD victims (<35 years) with a significant genetic component. The elucidation of the pathogenetic cause of death might be relevant for the prevention of further deaths within affected families. Aim of this study was to determine the portion of underlying genetic heart diseases among unexplained putative SCD cases from a large German forensic department...
November 1, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28980547/-the-age-specific-changes-in-the-histological-structure-of-the-thyroid-cartilage-in-the-men
#11
Yu I Pigolkin, M P Poletaeva, G V Zolotenkova, A V Volkov
The objective of the present study was to elucidate the morphological and morphometric characteristics of the human thyroid cartilage during different periods of life. The thyroid cartilages were harvested from 70 cadavers of the subjects of the masculine gender who had died at the age from 1 to 93 years from the non-violent causes and had neither injuries nor signs of pathological changes in the neck organs. The microscopic studies were carried out using the standard methods for the staining of the preparations with hematoxylin and eosin...
2017: Sudebno-meditsinskaia Ekspertiza
https://www.readbyqxmd.com/read/28980535/the-nail-as-an-investigative-tool-in-medicine-what-a-dermatologist-ought-to-know
#12
REVIEW
Chander Grover, Shikha Bansal
The nail is an important skin appendage, but not many dermatologists are aware of the importance it receives outside our specialty. This article focuses on the nail in non-dermatological contexts. The nail is a keratinized matrix capable of continuous growth with the ability to incorporate various compounds within its structure. Therefore it can be used to monitor long-term consumption of drugs. It is also an excellent source of germ-line DNA for genetic analyses. With an increased undrstanding of nail physiology, there is now a better understanding of its connection to various pathologies as well...
November 2017: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/28967810/scuba-diving-death-always-due-to-drowning-two-forensic-cases-and-a-review-of-the-literature
#13
I Aquila, F Pepe, M Manno, P Frati, S Gratteri, V Fineschi, P Ricci
Scuba diving is an increasingly common recreational activity. We describe the physiopathology of barotrauma in two cases where death was caused by pulmonary barotrauma while diving. An inspection and autopsy were carried out in both cases. The autopsy data were supported by post-mortem radiological investigation. Histological and toxicological analyses were also carried out, and dive computer and tank manometer analysis performed. In both cases, the cause of death was attributable to arterial gas embolism, resulting from pulmonary barotrauma subsequent to pulmonary over-distension...
January 1, 2017: Medico-legal Journal
https://www.readbyqxmd.com/read/28964983/death-due-to-non-traumatic-hemoperitoneum-in-milan-2002-2016-with-focus-on-two-cases-of-abdominal-apoplexy-idiopathic-spontaneous-hemoperitoneum-and-review-of-the-literature
#14
REVIEW
Alessio Battistini, Matteo Marchesi, Alberto Amadasi, Alessandra Rancati, Guendalina Gentile, Riccardo Zoja
Abdominal apoplexy, also known as idiopathic spontaneous hemoperitoneum, is a rare event related to sudden death, whose diagnosis and treatment is extremely challenging and whose pathologic mechanisms are still mainly unknown. It is frequently associated with vascular disorders (alterations in the vascular structures) and mainly linked to liver cirrhosis. However, the presence of hemoperitoneum may in such cases pose many challenges to forensic post-mortem examinations since the source of bleeding remains often unknown even after a careful and thorough dissection...
September 23, 2017: Legal Medicine
https://www.readbyqxmd.com/read/28913415/forensic-pathology-education-in-pathology-residency-a-survey-of-current-practices-a-novel-curriculum-and-recommendations-for-the-future
#15
Amanda Spencer, Wayne K Ross, Ronald E Domen
Forensic pathology is a fundamental part of anatomic pathology training during pathology residency. However, the lack of information on forensic teaching suggests the highly variable nature of forensic education. A survey of pathology residency program directors was performed to determine key aspects of their respective forensic rotations and curriculum. A total of 38.3% of programs from across the country responded, and the survey results show 5.6% don't require a forensic pathology rotation. In those that do, most forensic pathology rotations are 4 weeks long, are done at a medical examiner's office, and require set prerequisites...
January 2017: Acad Pathol
https://www.readbyqxmd.com/read/28889247/guidelines-for-autopsy-investigation-of-sudden-cardiac-death-2017-update-from-the-association-for-european-cardiovascular-pathology
#16
Cristina Basso, Beatriz Aguilera, Jytte Banner, Stephan Cohle, Giulia d'Amati, Rosa Henriques de Gouveia, Cira di Gioia, Aurelie Fabre, Patrick J Gallagher, Ornella Leone, Joaquin Lucena, Lubov Mitrofanova, Pilar Molina, Sarah Parsons, Stefania Rizzo, Mary N Sheppard, Maria Paz Suárez Mier, S Kim Suvarna, Gaetano Thiene, Allard van der Wal, Aryan Vink, Katarzyna Michaud
Although sudden cardiac death (SCD) is one of the most important modes of death in Western countries, pathologists and public health physicians have not given this problem the attention it deserves. New methods of preventing potentially fatal arrhythmias have been developed and the accurate diagnosis of the causes of SCD is now of particular importance. Pathologists are responsible for determining the precise cause and mechanism of sudden death but there is still considerable variation in the way in which they approach this increasingly complex task...
September 9, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28886207/the-biological-effects-of-kambo-is-there-a-relationship-between-its-administration-and-sudden-death
#17
Isabella Aquila, Santo Gratteri, Matteo A Sacco, Vittorio Fineschi, Simona Magi, Pasqualina Castaldo, Graziella Viscomi, Salvatore Amoroso, Pietrantonio Ricci
Kambo is a substance obtained from the skin secretions of a frog, Phyllomedusa bicolor, popular in the Amazon region, which is administered via the transdermal route. We report a case of 42-year-old man found dead in his house. Near the corpse, a plastic box labeled as "Kambo sticks" was found. The man was a chronic consumer of Kambo and no previous pathology or genetic disease emerged in clinical history from the declaration of his general practitioner. Autopsy investigations and toxicological analysis were performed...
September 8, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28866283/traumatic-brain-injury-comparison-between-autopsy-and-ante-mortem-ct
#18
Stephanie Panzer, Lidia Covaliov, Peter Augat, Oliver Peschel
PURPOSE: The aim of this study was to compare pathological findings after traumatic brain injury between autopsy and ante-mortem computed tomography (CT). A second aim was to identify changes in these findings between the primary posttraumatic CT and the last follow-up CT before death. METHODS: Through the collaboration between clinical radiology and forensic medicine, 45 patients with traumatic brain injury were investigated. These patients had undergone ante-mortem CT as well as autopsy...
August 26, 2017: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/28836139/post-mortem-ct-imaging-of-the-lungs-pathological-versus-non-pathological-findings
#19
REVIEW
Laura Filograna, Michael J Thali
Nowadays, the modern computed tomography techniques are more and more applied in forensic investigations. The detection of abnormalities in post-mortem computed tomography (PMCT) imaging of the lungs is very common. As in clinical imaging, also in post-mortem imaging the right interpretation of alterations has an extreme importance for the assessment of correct conclusions. This is even crucial when the radiologist who approaches the PMCT images is not routinely involved in forensic cases. The aim of this article is to provide radiologists who approach PMCT imaging cases with some indications for a proper and correct interpretation of pulmonary findings, to avoid misleading forensic conclusions...
August 23, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28831721/pekka-saukko-bernard-knight-knight-s-forensic-pathology-4th-ed-new-york-crc-press-taylor-and-francis-group-2016
#20
Roger W Byard
No abstract text is available yet for this article.
August 23, 2017: Forensic Science, Medicine, and Pathology
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