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https://www.readbyqxmd.com/read/28916922/evaluation-of-zmcct-haplotypes-for-genetic-improvement-of-maize-hybrids
#1
Yipu Li, Lixiu Tong, Lele Deng, Qiyu Liu, Yuexian Xing, Chao Wang, Baoshen Liu, Xiaohong Yang, Mingliang Xu
The elite ZmCCT haplotypes which have no transposable element in the promoter could enhance maize resistance to Gibberella stalk rot and improve yield-related traits, while having no or mild impact on flowering time. Therefore, they are expected to have great value in future maize breeding programs. A CCT domain-containing gene, ZmCCT, is involved in both photoperiod response and stalk rot resistance in maize. At least 15 haplotypes are present at the ZmCCT locus in maize germplasm, whereas only three of them are found in Chinese commercial maize hybrids...
September 15, 2017: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/28915611/metformin-increases-chemo-sensitivity-via-gene-downregulation-encoding-dna-replication-proteins-in-5-fu-resistant-colorectal-cancer-cells
#2
Sung-Hee Kim, Soon-Chan Kim, Ja-Lok Ku
Metformin is most widely prescribed for type 2 diabetes. Recently, evidences have shown that metformin has anticancer effects on pancreatic-, colorectal-, ovarian-, and other cancers. Because metformin has less adverse effects and is inexpensive, it could be a useful chemo-therapeutic agent with anticancer effects. In this study, we demonstrated metformin inhibited by cell proliferation, cell migration ability, clonogenic ability, and cancer stem cell population. Metformin also induced cell cycle arrest in parental-(SNU-C5), and 5-Fu resistant-colorectal cancer cell line (SNU-C5_5FuR)...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28914953/grafting-of-a-eu-3-tfac-complex-on-to-a-tb-3-metal-organic-framework-for-use-as-a-ratiometric-thermometer
#3
Anna M Kaczmarek, Ying-Ya Liu, Chunhua Wang, Brecht Laforce, Laszlo Vincze, Pascal Van Der Voort, Rik Van Deun
Microrods of [Tb2(bpydc)3(H2O)3]·nDMF (TbMOF) were employed as a platform for grafting a β-diketonate complex of Eu(3+) for the purpose of obtaining ratiometric luminescence thermometer materials. A straightforward post-synthetic functionalization is employed to obtain the TbMOF@Eu_tfac (tfac = trifluoroacetylacetonate) compounds. The emission color of the TbMOF@Eu compounds can be slightly tuned by varying the percentage of the grafted β-diketonate complex of Eu(3+). Also, as shown, the thermometric properties of the material can be tuned by the percentage of grafted β-diketonate complex of Eu(3+)...
September 15, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28914495/acculturation-based-family-conflict-a-validation-of-asian-american-family-conflict-scale-among-chinese-americans
#4
Shiyou Wu, Xiafei Wang, Qi Wu, Fuhua Zhai, Qin Gao
Acculturation-based family conflicts can influence parent-child relationships and children's development among immigrant families. The Asian American Family Conflict Scale (AAFCS) was developed to measure conflicting practices and values between parents and children in the context of acculturation. Given that considerable cultural and institutional changes have taken place in original countries for the Chinese immigrant population, it is important to investigate whether the factor structure of the AAFCS is appropriate for measuring the attitudes and practices of acculturation among the current Chinese immigrant population...
September 15, 2017: PsyCh Journal
https://www.readbyqxmd.com/read/28913578/loci-on-chromosomes-1a-and-2a-affect-resistance-to-tan-yellow-spot-in-wheat-populations-not-segregating-for-tsn1
#5
Manisha Shankar, Dorthe Jorgensen, Julian Taylor, Ken J Chalmers, Rebecca Fox, Grant J Hollaway, Stephen M Neate, Mark S McLean, Elysia Vassos, Hossein Golzar, Robert Loughman, Diane E Mather
QTL for tan spot resistance were mapped on wheat chromosomes 1A and 2A. Lines were developed with resistance alleles at these loci and at the tsn1 locus on chromosome 5B. These lines expressed significantly higher resistance than the parent with tsn1 only. Tan spot (syn. yellow spot and yellow leaf spot) caused by Pyrenophora tritici-repentis is an important foliar disease of wheat in Australia. Few resistance genes have been mapped in Australian germplasm and only one, known as tsn1 located on chromosome 5B, is known in Australian breeding programs...
September 14, 2017: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/28906365/the-antibiotic-susceptibility-patterns-of-uropathogens-among-children-with-urinary-tract-infection-in-shiraz
#6
Gholamreza Pouladfar, Mitra Basiratnia, Mojtaba Anvarinejad, Pejman Abbasi, Fatemeh Amirmoezi, Samaneh Zare
Urinary tract infection (UTI) is one of the most common bacterial infections in pediatrics. Delay in diagnosis and treatment can cause significant morbidity. The physicians knowledge regarding the symptoms, microorganisms that caused UTI, and effective antibiotics in a geographical area can help them to select the appropriate antibiotics. This study was performed to determine the prevalence of bacteria that cause UTI and their susceptibility to common antibiotics as well as the common symptoms and associated factors in children of Shiraz, Southern Iran...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28906243/pediatric-hearing-aid-management-challenges-among-hispanic-families
#7
Ana Caballero, Karen Muñoz, Karl White, Lauri Nelson, Melanie Domenech-Rodriguez, Michael Twohig
BACKGROUND: Hearing aid fitting in infancy has become more common in the United States as a result of earlier identification of hearing loss. Consistency of hearing aid use is an area of concern for young children, as well as other hearing aid management challenges parents encounter that may contribute to less-than-optimal speech and language outcomes. Research that describes parent hearing aid management experiences of Spanish-speaking Hispanic families, or the extent of their needs, is not available...
September 2017: Journal of the American Academy of Audiology
https://www.readbyqxmd.com/read/28903354/her2-isoforms-co-expression-differently-tunes-mammary-tumor-phenotypes-affecting-onset-vasculature-and-therapeutic-response
#8
Arianna Palladini, Giordano Nicoletti, Alessia Lamolinara, Massimiliano Dall'Ora, Tania Balboni, Marianna L Ianzano, Roberta Laranga, Lorena Landuzzi, Veronica Giusti, Claudio Ceccarelli, Donatella Santini, Mario Taffurelli, Enrico Di Oto, Sofia Asioli, Augusto Amici, Serenella M Pupa, Carla De Giovanni, Elda Tagliabue, Manuela Iezzi, Patrizia Nanni, Pier-Luigi Lollini
Full-length HER2 oncoprotein and splice variant Delta16 are co-expressed in human breast cancer. We studied their interaction in hybrid transgenic mice bearing human full-length HER2 and Delta16 (F1 HER2/Delta16) in comparison to parental HER2 and Delta16 transgenic mice. Mammary carcinomas onset was faster in F1 HER2/Delta16 and Delta16 than in HER2 mice, however tumor growth was slower, and metastatic spread was comparable in all transgenic mice. Full-length HER2 tumors contained few large vessels or vascular lacunae, whereas Delta16 tumors presented a more regular vascularization with numerous endothelium-lined small vessels...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28902368/smad4-re-expression-increases-the-sensitivity-to-parthenolide-in-colorectal-cancer
#9
Xuemei Li, Huike Yang, Jia Ke, Baoquan Liu, Xiaohong Lv, Xinlei Li, Yafang Zhang
Parthenolide (PT), a sesquiterpene lactone extracted from the plant feverfew, has been demonstrated to have anti-inflammatory and anticancer properties. Although PT has been revealed to markedly inhibit colorectal cancer cell proliferation, the inhibitory effects decrease with administration time. These findings revealed that colorectal cancer cells develop resistance to PT. However, the underlying mechanism is unclear. In the present study we observed significantly low expression of Smad4 in 3 PT-resistant cell lines (HCT‑116/PT, HT-29/PT and Caco-2/PT), which were obtained using in vitro concentration gradient-increased induction, but not in their parental cells...
October 2017: Oncology Reports
https://www.readbyqxmd.com/read/28901493/high-pemetrexed-sensitivity-of-docetaxel-resistant-a549-cells-is-mediated-by-tp53-status-and-downregulated-thymidylate-synthase
#10
Wei-Ting Kuo, Dom-Gene Tu, Ling-Yen Chiu, Gwo-Tarng Sheu, Ming-Fang Wu
The chemoresistance of non-small cell lung cancer (NSCLC) that occurs in docetaxel (DOC) chemotherapy substantially decreases the survival of patients. To overcome DOC-induced chemoresistance, we established DOC-selected A549 lung cancer sublines (A549/D16 and A549/D32) and revealed that both sublines were cross-resistant to vincristine (VCR) and doxorubicin (DXR). Notably, both sublines were more sensitive to pemetrexed (PEM) than parental cells according to MTT and clonogenic assays. The expression levels of thymidylate synthase (TS) and γ-glutamyl hydrolase (GGH) were downregulated in DOC-resistant sublines...
September 7, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28899501/modulation-of-p-glycoprotein-by-stemona-alkaloids-in-human-multidrug-resistance-leukemic-cells-and-structural-relationships
#11
Sonthaya Umsumarng, Pornsiri Pitchakarn, Supachai Yodkeeree, Wanisa Punfa, Sariya Mapoung, Rosdayati Alino Ramli, Stephen G Pyne, Pornngarm Limtrakul
BACKGROUND: Multidrug resistance (MDR) is a major reason for the failure of chemotherapy in the treatment of cancer patients. P-gp over-expression in MDR cancer cells is a multifactorial phenomenon with biochemical resistance mechanisms. Stemofoline (STF), isolated from Stemona bukillii, has been reported to be an MDR reversing compound. PURPOSE: This study investigated whether other Stemona alkaloids that had been purified from Stemonaceae plants exerted MDR modulation activity...
October 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28893118/emotional-and-behavioral-health-needs-in-elementary-school-students-in-an-underserved-hispanic-community
#12
Yuqing Guo, Julie Rousseau, Anna S Hsu, Priscilla Kehoe, Monique Daviss, Sara Flores, Patricia Renno, Kathleen Saunders, Susanne Phillips, Lorraine S Evangelista
High rates of mental health problems in adolescents have been well documented; less is known about elementary school children in disadvantaged communities. We examined emotional and behavioral health needs in 202 third and fourth graders enrolled in a charter school in a largely Hispanic community. The child-reported Revised Child Anxiety and Depression Scale-25 and Teacher's Report Form were used to evaluate mental health needs as perceived by these children and their teachers. The prevalence of teacher-reported depression and child self-reported anxiety was 7...
January 1, 2017: Journal of School Nursing: the Official Publication of the National Association of School Nurses
https://www.readbyqxmd.com/read/28892785/parental-gamma-irradiation-induces-reprotoxic-effects-accompanied-by-genomic-instability-in-zebrafish-danio-rerio-embryos
#13
Selma Hurem, Tânia Gomes, Dag A Brede, Elisabeth Lindbo Hansen, Stephen Mutoloki, Cristian Fernandez, Carmel Mothersill, Brit Salbu, Yetneberk A Kassaye, Ann-Karin Olsen, Deborah Oughton, Peter Aleström, Jan L Lyche
Gamma radiation represents a potential health risk to aquatic and terrestrial biota, due to its ability to ionize atoms and molecules in living tissues. The effects of exposure to (60)Co gamma radiation in zebrafish (Danio rerio) were studied during two sensitive life stages: gametogenesis (F0: 53 and 8.7mGy/h for 27 days, total doses 31 and 5.2Gy) and embryogenesis (9.6mGy/h for 65h; total dose 0.62Gy). Progeny of F0 exposed to 53mGy/h showed 100% mortality occurring at the gastrulation stage corresponding to 8h post fertilization (hpf)...
September 8, 2017: Environmental Research
https://www.readbyqxmd.com/read/28892476/induction-of-allopurinol-resistance-in-leishmania-infantum-isolated-from-dogs
#14
Daniel Yasur-Landau, Charles L Jaffe, Adi Doron-Faigenboim, Lior David, Gad Baneth
Resistance to allopurinol in zoonotic canine leishmaniasis has been recently shown to be associated with disease relapse in naturally-infected dogs. However, information regarding the formation of resistance and its dynamics is lacking. This study describes the successful in-vitro induction of allopurinol resistance in Leishmania infantum cultured under increasing drug pressure. Allopurinol susceptibility and growth rate of induced parasites were monitored over 23 weeks and parasite clones were tested at selected time points and compared to their parental lines, both as promastigotes and as amastigotes...
September 11, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28891354/brca2-protects-mammalian-cells-from-heat-shock
#15
Yosuke Nakagawa, Atsuhisa Kajihara, Akihisa Takahashi, Akiho S Murata, Masaya Matsubayashi, Soichiro S Ito, Ichiro Ota, Takahiko Nakagawa, Masatoshi Hasegawa, Tadaaki Kirita, Takeo Ohnishi, Eiichiro Mori
PURPOSE: Heat shock induces DNA double-strand breaks (DSBs) in mammalian cells. Mammalian cells are capable of repairing DSBs by utilising the homologous recombination (HR) pathway. Breast cancer susceptibility gene 2 (BRCA2) is known to regulate the HR pathway. Here, we investigate the role of BRCA2 in repairing DNA damage induced by heat shock. MATERIALS AND METHODS: Chinese hamster lung fibroblast cell lines and human tongue squamous cell carcinoma SAS cells were used...
September 10, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28889808/maternal-immune-and-affiliative-biomarkers-and-sensitive-parenting-mediate-the-effects-of-chronic-early-trauma-on-child-anxiety
#16
A Ulmer-Yaniv, A Djalovski, K Yirmiya, G Halevi, O Zagoory-Sharon, R Feldman
BACKGROUND: Chronic early trauma alters children's stress reactivity and increases the prevalence of anxiety disorders; yet the neuroendocrine and immune mechanisms underpinning this effect are not fully clear. Animal studies indicate that the mother's physiology and behavior mediate offspring stress in a system-specific manner, but few studies tested this external-regulatory maternal role in human children exposed to chronic stress. METHODS: We followed a unique cohort of children exposed to continuous wartime trauma (N = 177; exposed; N = 101, controls; N = 76)...
September 11, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28887770/optimization-of-1-h-decoupling-eliminates-sideband-artifacts-in-3d-trosy-based-triple-resonance-experiments
#17
Youlin Xia, Paolo Rossi, Marco Tonelli, Chengdong Huang, Charalampos G Kalodimos, Gianluigi Veglia
TROSY-based triple resonance experiments are essential for protein backbone assignment of large biomolecular systems by solution NMR spectroscopy. In a survey of the current Bruker pulse sequence library for TROSY-based experiments we found that several sequences were plagued by artifacts that affect spectral quality and hamper data analysis. Specifically, these experiments produce sidebands in the (13)C(t 1) dimension with inverted phase corresponding to (1)HN resonance frequencies, with approximately 5% intensity of the parent (13)C crosspeaks...
September 8, 2017: Journal of Biomolecular NMR
https://www.readbyqxmd.com/read/28887583/mir-608-regulating-the-expression-of-ribonucleotide-reductase-m1-and-cytidine-deaminase-is-repressed-through-induced-gemcitabine-chemoresistance-in-pancreatic-cancer-cells
#18
Azam Rajabpour, Ali Afgar, Habibollah Mahmoodzadeh, Jalal-E-Din Radfar, Farzad Rajaei, Ladan Teimoori-Toolabi
PURPOSE: Gemcitabine resistance is the main problem in pancreatic adenocarcinoma patients. Hence, we aimed to identify the correlation between expression of RRM1 and CDA as the resistance genes and their predicted targeting miR-608 in the resistant pancreatic cancer cell lines to gemcitabine. METHODS: Dual luciferase assay was performed to determine whether both RRM1 and CDA are targeted by miR-608 in 293T and pancreatic cancer cell lines. AsPC-1 and MIA PaCa-2 cell lines became gradually resistant to gemcitabine by exposing to the increasing doses of gemcitabine...
September 8, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/28887170/synthesis-and-evaluation-of-antitumor-anti-inflammatory-and-analgesic-activity-of-novel-deoxycholic-acid-derivatives-bearing-aryl-or-hetarylsulfanyl-moieties-at-the-c-3-position
#19
Irina I Popadyuk, Andrey V Markov, Ekaterina A Morozova, Valeriya O Babich, Oksana V Salomatina, Evgeniya B Logashenko, Marina A Zenkova, Tat'yana G Tolstikova, Nariman F Salakhutdinov
Novel deoxycholic acid (DCA) derivatives were stereoselectively synthesised with -OH and -CH2SR moieties at the C-3 position, where R was a substituted aryl [2-aminophenyl (8) or 4-chlorophenyl (9)] or hetaryl [1-methylimidazolyl (5), 1,2,4-triazolyl (6), 5-amino-1,3,4-thiadiazolyl (7), pyridinyl (10) or pyrimidinyl (11)]. These compounds were prepared in good yields from the C-3β-epoxy derivative 2 in the epoxide ring-opening reaction by S-nucleophiles. These derivatives were evaluated for their in vitro anti-proliferation activity in a panel of tumor cell lines...
September 5, 2017: Steroids
https://www.readbyqxmd.com/read/28886420/discriminant-validity-diagnostic-utility-and-parent-child-agreement-on-the-screen-for-child-anxiety-related-emotional-disorders-scared-in-treatment-and-non-treatment-seeking-youth
#20
B I Rappaport, D Pagliaccio, D S Pine, D N Klein, J M Jarcho
The Screen for Child Anxiety and Related Emotional Disorder (SCARED) may be differentially sensitive to detecting specific or comorbid anxiety diagnoses in treatment-seeking and non-treatment-seeking youth. We assessed the SCARED's discriminant validity, diagnostic utility, and informant agreement using parent- and self-report from healthy and treatment-seeking anxious youth (Study 1, N=585) and from non-treatment-seeking anxious youth (Study 2, N=331) diagnosed with generalized anxiety disorder (GAD), social anxiety disorder (SAD), or comorbid GAD+SAD...
August 30, 2017: Journal of Anxiety Disorders
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