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https://www.readbyqxmd.com/read/29164478/excited-state-and-non-linear-optical-properties-of-nir-absorbing-%C3%AE-thiophene-fused-bf2-azadipyrromethene-dyes-computational-investigation
#1
Yogesh Gawale, Lydia Rhyman, Mohamed I Elzagheid, Ponnadurai Ramasami, Nagaiyan Sekar
Density functional theory and time-dependent density functional theory computations were used to understand the electronic and photophysical parameters of NIR β-thiophene-fused BF2-azadipyrromethene dyes. The computed data are in good agreement with those obtained experimentally and they provide insights into the origin of red shifted optical spectra compared to the parent aza-BODIPY, low Stokes shift, non-linear optical responses and quantitative description of the singlet-triplet energy gap. The resultant decrease in the HOMO - LUMO energy gap is responsible for the red shift...
November 21, 2017: Journal of Fluorescence
https://www.readbyqxmd.com/read/29163668/sexual-and-reproductive-health-needs-and-risks-of-very-young-adolescent-refugees-and-migrants-from-myanmar-living-in-thailand
#2
Catherine Lee, Yasmina Aules, Samira Sami, Paw Kree Lar, Jennifer Schlect, Courtland Robinson
Background: The very young adolescent (VYA) population age 10-14 years is often neglected in the field of sexual and reproductive health (SRH) research due to the combined sensitivity of the topic and the young age group, resulting in little data about the SRH needs and concerns of VYA. In 2013, the Women's Refugee Commission (WRC), Johns Hopkins University (JHU), Adolescent and Reproductive Health Network (ARHN) and Karen Youth Organization (KYO) implemented qualitative participatory research to explore the SRH needs and risks of VYA...
2017: Conflict and Health
https://www.readbyqxmd.com/read/29162175/reward-sensitivity-impulse-control-and-social-cognition-as-mediators-of-the-link-between-childhood-family-adversity-and-externalizing-behavior-in-eight-countries
#3
Jennifer E Lansford, Jennifer Godwin, Marc H Bornstein, Lei Chang, Kirby Deater-Deckard, Laura Di Giunta, Kenneth A Dodge, Patrick S Malone, Paul Oburu, Concetta Pastorelli, Ann T Skinner, Emma Sorbring, Laurence Steinberg, Sombat Tapanya, Liane Peña Alampay, Liliana Maria Uribe Tirado, Suha M Al-Hassan, Dario Bacchini
Using data from 1,177 families in eight countries (Colombia, Italy, Jordan, Kenya, the Philippines, Sweden, Thailand, and the United States), we tested a conceptual model of direct effects of childhood family adversity on subsequent externalizing behaviors as well as indirect effects through psychological mediators. When children were 9 years old, mothers and fathers reported on financial difficulties and their use of corporal punishment, and children reported perceptions of their parents' rejection. When children were 10 years old, they completed a computerized battery of tasks assessing reward sensitivity and impulse control and responded to questions about hypothetical social provocations to assess their hostile attributions and proclivity for aggressive responding...
December 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/29162173/change-in-fk506-binding-protein-5-fkbp5-methylation-over-time-among-preschoolers-with-adversity
#4
Stephanie H Parade, Justin Parent, Kantoniony Rabemananjara, Ronald Seifer, Carmen J Marsit, Bao-Zhu Yang, Huiping Zhang, Audrey R Tyrka
FK506 binding protein 5 (FKBP5) alters stress response system functioning, and childhood maltreatment is associated with methylation of the FKBP5 gene. Yet it is unknown if maltreatment contributes to change in FKBP5 methylation over time. The current study draws upon a sample of 231 preschoolers, including 123 with child welfare documentation of moderate to severe maltreatment in the past 6 months, to understand if maltreatment contributes to change in FKBP5 methylation over a 6-month period. Review of child protection records and semistructured interviews in the home were used to assess maltreatment and exposure to other contextual stressors, as well as service utilization...
December 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/29162170/dynamic-stress-related-epigenetic-regulation-of-the-glucocorticoid-receptor-gene-promoter-during-early-development-the-role-of-child-maltreatment
#5
Justin Parent, Stephanie H Parade, Laura E Laumann, Kathryn K Ridout, Bao-Zhu Yang, Carmen J Marsit, Ronald Seifer, Audrey R Tyrka
Epigenetics processes may play a vital role in the biological embedding of early environmental adversity and the development of psychopathology. Accumulating evidence suggests that maltreatment is linked to methylation of the glucocorticoid receptor gene, nuclear receptor subfamily 3, group C, member 1 (NR3C1), which is a key regulator of the hypothalamus-pituitary-adrenal axis. However, prior work has been exclusively cross-sectional, greatly constraining our understanding of stress-related epigenetic processes over time...
December 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/29162169/stress-exposure-and-psychopathology-alter-methylation-of-the-serotonin-receptor-2a-htr2a-gene-in-preschoolers
#6
Stephanie H Parade, Andrew M Novick, Justin Parent, Ronald Seifer, Samantha J Klaver, Carmen J Marsit, Asi Polly Gobin, Bao-Zhu Yang, Audrey R Tyrka
Serotonin signaling pathways play a key role in brain development, stress reactivity, and mental health. Epigenetic alterations in the serotonin system may underlie the effect of early life stress on psychopathology. The current study examined methylation of the serotonin receptor 2A (HTR2A) gene in a sample of 228 children including 119 with child welfare documentation of moderate to severe maltreatment within the last 6 months. Child protection records, semistructured interviews in the home, and parent reports were used to assess child stress exposure, psychiatric symptoms, and behavior...
December 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/29162158/long-noncoding-rna-malat1-regulates-autophagy-associated-chemoresistance-via-mir-23b-3p-sequestration-in-gastric-cancer
#7
Hu YiRen, Yu YingCong, You Sunwu, Li Keqin, Tong Xiaochun, Chen Senrui, Chen Ende, Lin XiZhou, Chen Yanfan
BACKGROUND: Chemoresistance has long been recognized as a major obstacle in cancer therapy. Clarifying the underlying mechanism of chemoresistance would result in novel strategies to improve patient's response to chemotherapeutics. METHODS: lncRNA expression levels in gastric cancer (GC) cells was detected by quantitative real-time PCR (qPCR). MALAT1 shRNAs and overexpression vector were transfected into GC cells to down-regulate or up-regulate MALAT1 expression...
November 21, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/29160773/rationalizing-substituent-effects-in-1-azathioxanthone-photophysics
#8
Anne Kathrine R Junker, Thomas Just Sørensen
The influence of an electron donating substituent on the photophysical properties of 1-azathioxanthone dyes has been investigated using optical spectroscopy and theoretical models. The motivation behind the study is based on the fact that thioxanthones are efficient triplet sensitizers, and thus promising sensitizers for lanthanide centered emission. By adding an aza group to one of the phenyl ring systems, direct coordination to a lanthanide center becomes possible, which makes azathoixanthones great candidates as antenna chromophores in lanthanide(III) based dyes...
November 21, 2017: Methods and Applications in Fluorescence
https://www.readbyqxmd.com/read/29159486/program-components-of-psychosocial-interventions-in-foster-and-kinship-care-a-systematic-review
#9
REVIEW
Jacqueline Kemmis-Riggs, Adam Dickes, John McAloon
Foster children frequently experience early trauma that significantly impacts their neurobiological, psychological and social development. This systematic review examines the comparative effectiveness of foster and kinship care interventions. It examines the components within each intervention, exploring their potential to benefit child and carer well-being, particularly focussing on child behaviour problems, and relational functioning. Systematic searches of electronic databases included PsycINFO, MEDLINE, Web of Science Core Collection, the Cochrane Collaborations Register of Controlled Trials (CENTRAL) and Scopus to identify randomised or quasi-randomised trials of psychosocial foster/kinship care interventions, published between 1990 and 2016...
November 20, 2017: Clinical Child and Family Psychology Review
https://www.readbyqxmd.com/read/29157598/chinese-vietnamese-and-asian-indian-parents-perspectives-about-well-child-visits-a-qualitative-analysis
#10
Maya Ragavan, Wendy Li, A Rani Elwy, John Cowden, Megan Bair-Merritt
OBJECTIVES: Well-child visits are a critical component of pediatric healthcare; however, disparities in attendance and quality of care exist for Asian children. Limited research has explored Asian immigrant parents' perspectives about their well-child visit experience. METHODS: Qualitative interviews were conducted with Chinese, Vietnamese, and Asian Indian immigrant parents. Participants were recruited from community-based organizations in the Boston area. Interviews focused on parents' perceptions about well-child visits, including individual attitudes, social and cultural factors impacting their opinions, perceived behavioral control, and improving visits for Asian immigrant families...
November 17, 2017: Academic Pediatrics
https://www.readbyqxmd.com/read/29156708/a-preclinical-evaluation-of-the-mek-inhibitor-refametinib-in-her2-positive-breast-cancer-cell-lines-including-those-with-acquired-resistance-to-trastuzumab-or-lapatinib
#11
John O'Shea, Mattia Cremona, Clare Morgan, Malgorzata Milewska, Frankie Holmes, Virginia Espina, Lance Liotta, Joyce O'Shaughnessy, Sinead Toomey, Stephen F Madden, Aoife Carr, Naomi Elster, Bryan T Hennessy, Alex J Eustace
Purpose: The MEK/MAPK pathway is commonly activated in HER2-positive breast cancer, but little investigation of targeting this pathway has been undertaken. Here we present the results of an in vitro preclinical evaluation of refametinib, an allosteric MEK1/2 inhibitor, in HER2-positive breast cancer cell lines including models of acquired resistance to trastuzumab or lapatinib. Methods: A panel of HER2-positive breast cancer cells were profiled for mutational status and also for anti-proliferative response to refametinib alone and in combination with the PI3K inhibitor (PI3Ki) copanlisib and the HER2-targeted therapies trastuzumab and lapatinib...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29154642/sensory-processing-sensitivity-as-a-marker-of-differential-susceptibility-to-parenting
#12
Meike Slagt, Judith Semon Dubas, Marcel A G van Aken, Bruce J Ellis, Maja Deković
In this longitudinal multiinformant study negative emotionality and sensory processing sensitivity were compared as susceptibility markers among kindergartners. Participating children (N = 264, 52.9% boys) were Dutch kindergartners (Mage = 4.77, SD = 0.60), followed across three waves, spaced seven months apart. Results show that associations between parenting and child behavior did not depend on children's negative emotionality. Sensory processing sensitivity, however, interacted with both (changes in) negative and (changes in) positive parenting in predicting externalizing, but not prosocial, behavior...
November 20, 2017: Developmental Psychology
https://www.readbyqxmd.com/read/29154589/down-regulation-of-amygdala-response-to-infant-crying-a-role-for-distraction-in-maternal-emotion-regulation
#13
Christine Firk, Brigitte Dahmen, Christin Lehmann, Beate Herpertz-Dahlmann, Kerstin Konrad
Infant crying elicits caregiving behaviors, which are indispensable for fulfilling the infant's needs. However, infant crying can also evoke negative and angry feelings in the caregiver. Therefore, parents need to regulate their own negative emotions to infant crying to sensitively respond to the distressed infant. Thus, the current study aims to examine the neural basis of emotional reactivity and emotional regulation in response to infant crying using functional MRI in primiparous mothers (N = 26). Amygdala activation in response to infant crying was negatively associated with maternal sensitivity and maternal nonhostility during mother-infant interaction...
November 20, 2017: Emotion
https://www.readbyqxmd.com/read/29152860/-pretty-pressure-from-peers-parents-and-the-media-a-longitudinal-study-of-appearance-based-rejection-sensitivity
#14
Haley J Webb, Melanie J Zimmer-Gembeck, Allison M Waters, Lara J Farrell, Drew Nesdale, Geraldine Downey
Drawing from the tripartite sociocultural model of body image, the researchers examined whether direct messages and modeling from peers, parents, and media were concurrently and prospectively associated with appearance-based rejection sensitivity (appearance-RS) in young adolescents (Mage  = 12.0 years). Appearance-RS was higher among those who concurrently reported more appearance-related teasing and pressure by peers, more parent teasing, and greater acceptance of media appearance ideals. In prospective analyses, greater increases in appearance-RS over 1 year were found for adolescents who perceived higher levels of parental appearance-related teasing and negative attitudes about their own appearance...
December 2017: Journal of Research on Adolescence: the Official Journal of the Society for Research on Adolescence
https://www.readbyqxmd.com/read/29152461/use-of-toll-like-receptor-assays-for-the-detection-of-bacterial-contaminations-in-icodextrin-batches-released-for-peritoneal-dialysis
#15
Hêla Hacine-Gherbi, Agnès Denys, Mathieu Carpentier, Arnaud Heysen, Pierrick Duflot, Pierre Lanos, Fabrice Allain
Icodextrin is a starch derivative used for preparing solutions of peritoneal dialysis. Unfortunately, peptidoglycans (PGN) and lipopolysaccharides (LPS) have been reported to contaminate certain icodextrin batches and to contribute to the development of sterile peritonitis. The decision of selecting or rejecting icodextrin batches is however difficult, because of limitations in the detection of these bacterial contaminants. Besides monocyte activation tests of cytokine release, a number of bio-assays using stably TLR-transfected cell lines have been developed...
2017: Toxicology Reports
https://www.readbyqxmd.com/read/29151965/combined-inhibitions-of-glycolysis-and-akt-autophagy-can-overcome-resistance-to-egfr-targeted-therapy-of-lung-cancer
#16
Mingtong Ye, Sufan Wang, Ting Wan, Rui Jiang, Yun Qiu, Lei Pei, Nengzhi Pang, Yuanling Huang, Yufeng Huang, Zhenfeng Zhang, Lili Yang
Efficacy of EGFR-targeted tyrosine kinase inhibitors (TKIs), such as erlotinib, to treat human non-small cell lung cancers (NSCLCs) with activating mutations in EGFR is not persistent due to drug resistance. Reprogramming in energy (especially glucose) metabolism plays an important role in development and progression of acquired resistance in cancer cells. We hypothesize that glucose metabolism in EGFR-TKI sensitive HCC827 cells and erlotinib-resistant sub-line of HCC827 (which we name it as erlotinib-resistant 6, ER6 cells in this study) is different and targeting glucose metabolism might be a treatment strategy for erlotinib-resistant NSCLCs...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/29151941/zeb1-promotes-oxaliplatin-resistance-through-the-induction-of-epithelial-mesenchymal-transition-in-colon-cancer-cells
#17
Cao Guo, Junli Ma, Ganlu Deng, Yanlin Qu, Ling Yin, Yiyi Li, Ying Han, Changjing Cai, Hong Shen, Shan Zeng
Background: Oxaliplatin (OXA) chemotherapy is widely used in the clinical treatment of colon cancer. However, chemo-resistance is still a barrier to effective chemotherapy in cases of colon cancer. Accumulated evidence suggests that the epithelial mesenchymal transition (EMT) may be a critical factor in chemo-sensitivity. The present study investigated the effects of Zinc finger E-box binding homeobox 1 (ZEB1) on OXA-sensitivity in colon cancer cells. Method: ZEB1expression and its correlation with clinicopathological characteristics were analyzed using tumor tissue from an independent cohort consisting of 118 colon cancer (CC) patients who receiving OXA-based chemotherapy...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/29151829/validation-of-poiba-how-do-we-eat-questionnaire-in-9-10-years-old-schoolchildren
#18
Carles Ariza, Teresa Arechavala, Sara Valmayor, Gemma Serral, Albert Moncada, Luis Rajmil, Anna Schiaffino, Francesca Sánchez-Martínez
Background: It is difficult to obtain good food reports with Food Frequency Questionnaires (FFQ) among children. In addition, validated questionnaires are scarce. Objective: The aim of this study was to validate the 'POIBA-How do we eat?' (POIBA-HDWE) FFQ and whether it could be administered to children under 10 years of age. Design: We validated the FFQ POIBA-HDWE as part of the Childhood Obesity Prevention Program (POIBA project) in Barcelona. Forty-two out of 63 primary school students (9-10 years old) answered three questionnaires: FFQ POBA-HDWE; another questionnaire, 'POIBA-How do our children eat?' (POIBA-HDOCE), which was administered to the children's parents; and the 24-h recall computer program 'Young Adolescents' Nutrition Assessment on Computer' (YANA-C), which was used on three different days as a gold standard...
2017: Food & Nutrition Research
https://www.readbyqxmd.com/read/29150738/the-autism-family-experience-questionnaire-afeq-an-ecologically-valid-parent-nominated-measure-of-family-experience-quality-of-life-and-prioritised-outcomes-for-early-intervention
#19
Kathy Leadbitter, Catherine Aldred, Helen McConachie, Ann Le Couteur, Dharmi Kapadia, Tony Charman, Wendy Macdonald, Erica Salomone, Richard Emsley, Jonathan Green
There is a lack of measures that reflect the intervention priorities of parents of children with autism spectrum disorder (ASD) and that assess the impact of interventions on family experience and quality of life. The Autism Family Experience Questionnaire (AFEQ) was developed through focus groups and online consultation with parents, and reflected parental priorities. It was then administered to the parents of children enrolled in the Pre-school Autism Communication Trial and its 6-year follow-up study. The AFEQ showed good convergent validity with well-established measures of child adaptive functioning, parental mental health and parental wellbeing...
November 18, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29144840/feasibility-of-using-the-general-movements-assessment-of-infants-in-the-united-states
#20
Eileen Ricci, Christa Einspieler, Alexa K Craig
AIMS: To pilot the practicality of administering the Prechtl General Movements Assessment of infants (GMA) in the Neonatal Intensive Care Unit (NICU) setting and at home to infants at risk for developing cerebral palsy (CP). Additional aims included assessing inter-rater reliability and comparing GMA predictions to AIMS motor assessment at 12 months. METHODS: 12 "at risk" infants were recruited by convenience sample. Video recordings were obtained in the NICU and provided by parents after discharge...
November 16, 2017: Physical & Occupational Therapy in Pediatrics
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