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Parental sensitivity

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https://www.readbyqxmd.com/read/29334626/parenting-predicts-strange-situation-cortisol-reactivity-among-children-adopted-internationally
#1
Carrie E DePasquale, K Lee Raby, Julie Hoye, Mary Dozier
The functioning of the hypothalamic pituitary adrenal (HPA) axis can be altered by adverse early experiences. Recent studies indicate that children who were adopted internationally after experiencing early institutional rearing and unstable caregiving exhibit blunted HPA reactivity to stressful situations. The present study examined whether caregiving experiences post-adoption further modulate children's HPA responses to stress. Parental sensitivity during naturalistic parent-child play interactions was assessed for 66 children (M age = 17...
January 4, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29333638/rapid-profiling-of-polymeric-phenolic-acids-in-salvia-miltiorrhiza-by-hybrid-data-dependent-targeted-multistage-mass-spectrometry-acquisition-based-on-expected-compounds-prediction-and-fragment-ion-searching
#2
Yao Shen, Zijin Feng, Min Yang, Zhe Zhou, Sumei Han, Jinjun Hou, Zhenwei Li, Wanying Wu, De-An Guo
Phenolic acids are the major water-soluble components in Salvia miltiorrhiza (> 5%). According to previous studies, many of them contribute to the cardiovascular effects and antioxidant effects of S. miltiorrhiza. Polymeric phenolic acids can be considered as the tanshinol derived metabolites, e.g., dimmers, trimers and tetramers. A strategy combined with tanshinol-based expected compounds prediction, total ion chromatogram filtering, Fragment Ion Searching and parent list-based multistage mass spectrometry acquisition by Linear Trap Quadropole-orbitrap Velos Mass Spectrometry was proposed to rapid profile polymeric phenolic acids in S...
January 15, 2018: Journal of Separation Science
https://www.readbyqxmd.com/read/29331617/asthma-predictive-index-in-relation-to-respiratory-mechanics-by-impulse-oscillometry-in-recurrent-wheezers
#3
T Arikoglu, S B Batmaz, D D Yildirim, Ö Tezol, G Bozlu, S Kuyucu
BACKGROUND: The identification of children who will have persistent asthma has become a focus of recent research. The aim of this study was to assess whether impulse oscillometry (IOS) has a diagnostic value to predict modified API (asthma predictive index) in pre-schoolers with recurrent wheezing. METHODS: Pre-school children aged 3-6 years with recurrent wheezing were enrolled. The study population was divided into two groups based on mAPI criteria. Lung function was assessed by IOS...
January 10, 2018: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/29330999/reasons-of-self-discharge-from-nursery-of-a-tertiary-care-hospital
#4
Rabia Abbas, Khawaja Ahmad Irfan Waheed, Talal Waqar, Muhammad Anwar, Rafia Gul, Sikandar Hayat, Syeda Tehseen Fatima, Muhammad Azhar
BACKGROUND: Patients who leave against medical advice (LAMA) from a health facility is a recognized problem. In neonatology practice this issue is particularly sensitive as repercussions can be severe. The purpose of this study was to evaluate the factors influencing the decision of parents to self-discharge their babies against medical advice. METHODS: This descriptive case series was conducted in the Department of Neonatology, of the Children's Hospital and the Institute of Child Health, Lahore from January to June 2015...
October 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/29330555/performance-of-low-income-dual-language-learners-attending-english-only-schools-on-the-clinical-evaluation-of-language-fundamentals-fourth-edition-spanish
#5
Beatriz Barragan, Anny Castilla-Earls, Lourdes Martinez-Nieto, M Adelaida Restrepo, Shelley Gray
Purpose: The aim of this study was to examine the performance of a group of Spanish-speaking, dual language learners (DLLs) who were attending English-only schools and came from low-income and low-parental education backgrounds on the Clinical Evaluation of Language Fundamentals-Fourth Edition, Spanish (CELF-4S; Semel, Wiig, & Secord, 2006). Method: Spanish-speaking DLLs (N = 656), ages 5;0 (years;months) to 7;11, were tested for language impairment (LI) using the core language score of the CELF-4S and the English Structured Photographic Expressive Language Test (Dawson, Stout, & Eyer, 2003)...
January 12, 2018: Language, Speech, and Hearing Services in Schools
https://www.readbyqxmd.com/read/29330019/parental-decisional-regret-and-views-about-optimal-timing-of-female-genital-restoration-surgery-in-congenital-adrenal-hyperplasia
#6
Konrad M Szymanski, Benjamin Whittam, Martin Kaefer, Heather Frady, Jessica T Casey, Vi T Tran, Mark P Cain, Richard C Rink
PURPOSE: The role of female genital restoration surgery (FGRS) in girls with congenital adrenal hyperplasia (CAH) is controversial, with no long-term parent-reported outcomes available. Decisional regret (DR) affects most parents after their children's treatment of pediatric conditions, including hypospadias. We aimed to assess parental DR after FGRS in infancy or toddlerhood and explore optimal timing for surgery. MATERIALS AND METHODS: One-hundred and six parents of females with CAH undergoing FGRS before 3 years old and followed at our institution (1999-2017) were invited to enroll online...
December 28, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29328006/parent-guardian-knowledge-regarding-implanted-shunt-type-setting-and-symptoms-of-malfunction-infection
#7
Laurie L Ackerman, Daniel H Fulkerson, Andrew Jea, Jodi L Smith
OBJECTIVE Patients with shunts often interact with providers distant from their primary hospital, making it important that the parent(s)/guardian(s) is well versed in the type of shunt implanted and symptoms of malfunction/infection. This is particularly important with magnetic-sensitive programmable valves, as the use of MRI becomes more prevalent. METHODS Over a 6-month period, primary caregivers of 148 consecutive patients who received shunts were prospectively administered questionnaires at clinic visits...
January 12, 2018: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29327155/downregulation-of-mir-503-contributes-to-the-development-of-drug-resistance-in-ovarian-cancer-by-targeting-pi3k-p85
#8
Di Wu, Pan Lu, Xue Mi, Jinwei Miao
OBJECTIVE: Cisplatin is an important chemotherapeutic agent frequently used in the treatment of ovarian cancer. However, resistance to cisplatin is an obstacle to the treatment of ovarian cancer. Recently, many studies have demonstrated that microRNAs (miRNAs) are involved in the drug resistance of ovarian cancer cells. In this study, we explored the role of miR-503 in cisplatin-resistant ovarian cancer. MATERIALS AND METHODS: To investigate the relationship between miR-503 expression and the sensitivity of ovarian cancer cells to cisplatin, the cells were transfected with miR-503 mimics/inhibitors...
January 11, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29326840/reproductive-gene-expression-in-a-coral-reef-fish-exposed-to-increasing-temperature-across-generations
#9
Heather D Veilleux, Jennifer M Donelson, Philip L Munday
Reproduction in marine fish is generally tightly linked with water temperature. Consequently, when adults are exposed to projected future ocean temperatures, reproductive output of many species declines precipitously. Recent research has shown that in the common reef fish, Acanthochromis polyacanthus, step-wise exposure to higher temperatures over two generations (parents: +1.5°C, offspring: +3.0°C) can improve reproductive output in the F2 generation compared to F2 fish that have experienced the same high temperatures over two generations (F1 parents: +3...
2018: Conservation Physiology
https://www.readbyqxmd.com/read/29326761/prevalence-rate-of-adolescent-idiopathic-scoliosis-results-of-school-based-screening-in-surabaya-indonesia
#10
I S Komang-Agung, S B Dwi-Purnomo, A Susilowati
Introduction: Scoliosis is a lateral spinal deformity of 10 degrees or more, resulting in a C-shaped or S-shaped curve of the spine. Information about adolescent idiopathic scoliosis (AIS) prevalence rate is important not only for paediatric health care planning strategy but also for parent's awareness. This study aims to find the suitable inclination cut-off angle and the prevalence rate of AIS in Surabaya, Indonesia. Materials and Methods: This is a descriptive cross-sectional study conducted in 2010. We performed stratified random sampling of 784 Elementary and Junior High School students in Surabaya between 9-16 years of age...
November 2017: Malaysian Orthopaedic Journal
https://www.readbyqxmd.com/read/29321028/health-condition-and-familial-factors-associated-with-health-related-quality-of-life-in-adolescents-with-congenital-heart-disease-a-cross-sectional-study
#11
Yu-Mi Im, Tae-Jin Yun, Sunhee Lee
BACKGROUND: The focus of clinical care after the repair of congenital heart disease has shifted from saving life of the patient to the patient's quality of life. The purpose of this study was to examine the health condition and familial factors associated with the health related quality of life of adolescents with congenital heart disease. METHODS: Ninety-eight adolescents aged 13-19 years were collected from a congenital heart clinic from July 22 to August 23, 2013...
January 10, 2018: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/29321004/rcc2-over-expression-in-tumor-cells-alters-apoptosis-and-drug-sensitivity-by-regulating-rac1-activation
#12
Nan Wu, Dong Ren, Su Li, Wenli Ma, Shaoyan Hu, Yan Jin, Sheng Xiao
BACKGROUND: Small GTP binding protein Rac1 is a component of NADPH oxidases and is essential for superoxide-induced cell death. Rac1 is activated by guanine nucleotide exchange factors (GEFs), and this activation can be blocked by regulator of chromosome condensation 2 (RCC2), which binds the switch regions of Rac1 to prevent access from GEFs. METHODS: Three cancer cell lines with up- or down-regulation of RCC2 were used to evaluate cell proliferation, apoptosis, Rac1 signaling and sensitivity to a group of nine chemotherapeutic drugs...
January 10, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29318622/fish-oil-in-infancy-protects-against-food-allergy-in-iceland-results-from-a-birth-cohort-study
#13
Michael Clausen, Kristjan Jonasson, Thomas Keil, Kirsten Beyer, Sigurveig T Sigurdardottir
BACKGROUND: Consumption of oily fish or fish oil during pregnancy, lactation, and infancy has been linked to a reduction in the development of allergic diseases in childhood. METHODS: In an observational study, Icelandic children (n = 1304) were prospectively followed from birth to 2.5 years with detailed questionnaires administered at birth and at one and two years of age, including questions about fish oil supplementation. Children with suspected food allergy were invited for physical examinations, allergic sensitization tests, and a double-blind, placebo-controlled food challenge if the allergy testing or clinical history indicated food allergy...
January 10, 2018: Allergy
https://www.readbyqxmd.com/read/29316188/evidence-for-activation-of-nitenpyram-by-a-mitochondrial-cytochrome-p450-in-drosophila-melanogaster
#14
Thomas W R Harrop, Shane Denecke, Ying Ting Yang, Janice Chan, Phillip J Daborn, Trent Perry, Philip Batterham
BACKGROUND: Nitenpyram is a member of the economically important neonicotinoid class of insecticides. The in vivo metabolism of nitenpyram is not well characterised, but cytochrome P450 activity is the major mechanism of resistance to neonicotinoids identified in insect pests, and P450s metabolise other neonicotinoids including imidacloprid. RESULTS: Here, we used the GAL4/UAS system to direct RNAi against the cytochrome P450 redox partners to interrupt P450 functions in specific tissues in Drosophila melanogaster...
January 9, 2018: Pest Management Science
https://www.readbyqxmd.com/read/29315077/improved-medical-alert-id-ownership-and-utilization-in-youth-with-congenital-adrenal-hyperplasia-following-a-parent-educational-intervention
#15
Alaina P Vidmar, Jonathan F Weber, Christina M Koppin, Roshanak Monzavi, Mimi S Kim
BACKGROUND: Classical congenital adrenal hyperplasia (CAH) is a potentially life-threatening condition, and adrenal crisis is a major cause of morbidity and mortality in affected children. Medical-alert identification (ID) could prevent complications of adrenal crisis by identifying the need for time-sensitive, critical treatment. Our objectives were to evaluate usage of medical-alert IDs by CAH youth, ownership and awareness of IDs amongst their parents, and the effect of an in-clinic educational intervention on ID utilization...
January 9, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29314419/convergent-validity-of-actigraphy-with-polysomnography-and-parent-reports-when-measuring-sleep-in-children-with-down-syndrome
#16
A J Esbensen, E K Hoffman, E Stansberry, R Shaffer
BACKGROUND: There is a need for rigorous measures of sleep in children with Down syndrome as sleep is a substantial problem in this population and there are barriers to obtaining the gold standard polysomnography (PSG). PSG is cost-prohibitive when measuring treatment effects in some clinical trials, and children with Down syndrome may not cooperate with undergoing a PSG. Minimal information is available on the validity of alternative methods of assessing sleep in children with Down syndrome, such as actigraphy and parent ratings...
January 5, 2018: Journal of Intellectual Disability Research: JIDR
https://www.readbyqxmd.com/read/29314334/wheezing-and-infantile-colic-are-associated-with-neonatal-antibiotic-treatment
#17
Berthe C Oosterloo, Ruurd M van Elburg, Nicole B Rutten, Carin M Bunkers, Clarissa E Crijns, Clemens B Meijssen, Johanna H Oudshoorn, Ger T Rijkers, Cornelis K van der Ent, Arine M Vlieger
BACKGROUND: Cohort studies have suggested that early life antibiotic treatment is associated with increased risk of atopy. We determined whether antibiotic treatment already in the first week of life increases the risk for atopic and non-atopic disorders. METHODS: The INCA study is a prospective observational birth cohort study of 436 term infants, with follow-up of one year. 151 neonates received broad-spectrum antibiotics for suspected neonatal infection (AB+), versus a healthy untreated control group (N=285) (AB-)...
January 4, 2018: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29311237/evaluation-of-cpxra-as-a-therapeutic-target-for-uropathogenic-escherichia-coli-infections
#18
Lana Dbeibo, Julia J van Rensburg, Sara N Smith, Kate R Fortney, Dharanesh Gangaiah, Hongyu Gao, Juan Marzoa, Yunlong Liu, Harry L T Mobley, Stanley M Spinola
CpxRA is an envelope stress response system found in all species of Enterobacteriaceae; CpxA has kinase activity for CpxR and phosphatase activity for phospho-CpxR, a transcription factor. CpxR also accepts phosphate groups and acetyl phosphate, a glucose metabolite. Activation of CpxR increases transcription of genes encoding for membrane repair and downregulates virulence determinants. We hypothesized that activation of CpxR could serve as an antimicrobial/antivirulence strategy and discovered compounds that activate CpxR in Escherichia coli by inhibiting CpxA phosphatase activity...
January 8, 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29310343/cerebrospinal-fluid-real-time-quaking-induced-conversion-test-for-sporadic-creutzfeldt-jakob-disease-in-an-18-year-old-woman-a-case-report
#19
Yuan Yao, Xiaoping Dong, Hongzhi Guan, Qiang Lu
RATIONALE: Sporadic Creutzfeldt-Jakob disease (sCJD) mainly occurs in the elderly, with the peak age of onset ranging from 55 to 75 years. The symptoms of sCJD are not unique, and laboratory tests such as magnetic resonance imaging (MRI), electroencephalogram (EEG) and cerebrospinal fluid (CSF)14-3-3 protein have low sensitivity or specificity. Therefore, excluding treatable diseases and establishing a diagnosis could be difficult in young patients with suspected sCJD. Recently, real-time quaking-induced conversion (RT-QuIC) has been used in the diagnosis of sCJD, with more than 95% sensitivity and 100% specificity...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29308955/a-qualitative-study-of-clinical-reasoning-in-physiotherapy-with-preterm-infants-and-their-parents-action-and-interaction
#20
Ragnhild B Håkstad, Aud Obstfelder, Gunn Kristin Øberg
BACKGROUND: Physiotherapists (PTs) in primary health care provide services to preterm infants and their parents after hospital discharge. The service should be collaborative and individualized to meet the family's needs. In this study, we analyze pediatric PTs' collaborative work in the clinical setting and investigate the PTs' emerging clinical reasoning (CR) in interaction with the infant and parent(s). METHODS: The study is based on observations of 20 physical therapy sessions and 20 interviews with PTs...
January 8, 2018: Physiotherapy Theory and Practice
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