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https://www.readbyqxmd.com/read/28329845/spatiotemporal-progression-and-remission-of-lesions-in-the-rat-brain-following-acute-intoxication-with-diisopropylfluorophosphate
#1
Sílvia Sisó, Brad A Hobson, Danielle J Harvey, Donald A Bruun, Douglas J Rowland, Joel R Garbow, Pamela J Lein
Similar to organophosphate (OP) nerve agents, diisopropylfluorophosphate (DFP) rapidly and irreversibly inhibits acetylcholinesterase, leading to convulsions that can progress to status epilepticus (SE). However, in contrast to the OP nerve agents, the long-term consequences of DFP-induced SE are not well known. Thus, we characterized the spatiotemporal profile of neuropathology during the first two months following acute DFP intoxication. Adult, male Sprague Dawley rats administered pyridostigmine bromide (0...
March 7, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28329842/magnetic-resonance-imaging-reveals-progressive-brain-injury-in-rats-acutely-intoxicated-with-diisopropylfluorophosphate
#2
Brad A Hobson, Sílvia Sisó, Douglas J Rowland, Danielle J Harvey, Donald A Bruun, Joel R Garbow, Pamela J Lein
Acute intoxication with organophosphates (OPs) can trigger seizures that progress to status epilepticus, and survivors often exhibit chronic neuropathology, cognitive impairment, affective disorders and/or electroencephalographic abnormalities. Understanding how acute injury transitions to persistent neurological sequelae is critical to developing medical countermeasures for mitigating damage following OP-induced seizures. Here, we used in vivo magnetic resonance imaging (MRI) to monitor the spatiotemporal patterns of neuropathology for one month after acute intoxication with diisopropylfluorophosphate (DFP)...
March 7, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28325700/the-relationship-between-preoperative-needle-electromyography-findings-and-muscle-power-restoration-after-surgery-in-severe-carpal-tunnel-syndrome-patients
#3
Yuki Hara, Yasumasa Nishiura, Naoyuki Ochiai, Shinji Murai, Masashi Yamazaki
PURPOSE: Needle electromyography provides essential information about the functional aspects of the muscle. But little attention has been given in the literature to needle electromyography examinations in carpal tunnel syndrome. We examined the relationship between preoperative needle electromyography findings and functional recovery of the abductor pollicis brevis (APB) muscle in severe carpal tunnel syndrome patients. METHODS: The subjects of this study were 49 patients, 58 hands, who fit the following 5 criteria: (1) idiopathic carpal tunnel syndrome; (2) pre-op MMT grade of the APB muscle was M0 or M1; (3) APB-CMAP (compound muscle action potential) was not evoked in a median nerve conduction study; (4) needle electromyography of the APB muscle had been done; (5) underwent carpal tunnel release only...
March 18, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/28324248/incorporation-of-flaxseed-flour-as-a-dietary-source-for-ala-increases-bone-density-and-strength-in-post-partum-female-rats
#4
Danielle Cavalcante Ribeiro, Aline D'Avila Pereira, Fernanda Carvalho de Santana, Jorge Mancini-Filho, Eduardo Moreira da Silva, Carlos Alberto Soares da Costa, Gilson Teles Boaventura
In women, bone mass undergoes changes during pregnancy and the postpartum period, which has a risk for subsequent development of osteoporosis. Thus, the present study aims to evaluate the effects of flaxseed flour in femur quality during post-weaning of dam rats. After weaning, the rats were divided into control (C, n = 7) and experimental (F, n = 7) groups treated with a diet containing 25 g of flaxseed flour in the lactating period and 15 g in the maintenance period. After 51 days post-partum, serum hormone, fatty acids composition, bone compartments, computed tomography, and biomechanical analyses were determined...
March 21, 2017: Lipids
https://www.readbyqxmd.com/read/28324215/surgical-treatment-of-osteoporotic-thoraco-lumbar-compressive-fractures-the-use-of-pedicle-screw-with-augmentation-pmma
#5
Massimo Girardo, P Cinnella, G Gargiulo, P Viglierchio, A Rava, S Aleotti
INTRODUCTION: The osteoporosis prevalence in population is age related. The aim of this single-center observational study was evaluate the middle- to long-term performance of cement (PMMA) augmented fenestrated pedicle screws in elderly patients with thoraco-lumbar compressive fractures by osteoporosis. MATERIALS AND METHODS: From 2011 to 2015 we treated 52 patients (20 males and 32 females) suffering from somatic osteoporotic fractures (T10-L2). The average age was 73...
March 21, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28320520/national-survey-for-bariatric-procedures-in-adolescent-long-time-follow-up
#6
Roberto Luca Castellani, Mauro Toppino, Franco Favretti, Francesco Saverio Camoglio, Nicola Zampieri
INTRODUCTION: The role of bariatric surgery and its role in adolescent is still under discussion worldwide. The aim of this study is to report an Italian survey for bariatric procedures in adolescents and the outcome with a medium and long-term follow-up. MATERIALS AND METHODS: We retrospectively analyzed consecutive data added into the Italian register of the society for bariatric surgery(period 2000-2010). We evaluated all patients treated in a 10-year period with a mean follow-up of 3 years...
March 14, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28315346/inhibition-of-osteoporosis-by-the-%C3%AE-v%C3%AE-3-integrin-antagonist-of-rhodostomin-variants
#7
Tzu-Hung Lin, Rong-Sen Yang, Huang-Ju Tu, Houng-Chi Liou, Yen-Ming Lin, Woie-Jer Chuang, Wen-Mei Fu
Integrins are heterodimeric cell surface receptors that mediate cell-cell and cell-matrix interaction. The vitronectin and osteopontin receptor αvβ3 integrin has increased expression levels and is implicated in the adhesion, activation, and migration of osteoclasts on the bone surface as well as osteoclast polarization. αvβ3 integrin plays an important role in osteoclast differentiation and resorption. In addition, Arg-Gly-Asp (RGD)-containing peptides, small molecular inhibitors, and antibodies to αvβ3 integrin have been shown to inhibit bone resorption in vitro and in vivo...
March 14, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28299388/the-combination-of-tibial-anterior-translation-and-axial-rotation-into-a-single-biomechanical-factor-improves-the-prediction-of-patient-satisfaction-over-each-factor-alone-in-patients-with-acl-reconstructed-knees
#8
Thomas P Branch, Shaun K Stinton, William C Hutton, Philippe Neyret
PURPOSE: The purpose of this study was to identify biomechanical factors, in both reconstructed and healthy knees, that correlate with patient satisfaction after ACL reconstruction. METHODS: Seventeen patients who had undergone unilateral ACL reconstruction were reviewed 9 years post-op. Patients completed subjective questionnaires and underwent manual knee laxity testing (Lachman-Trillat, KT-1000, and pivot shift) and automated laxity testing. During automated testing, both legs were rotated into external rotation and then internal rotation until peak rotational torque reached 5...
March 15, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28299378/factors-associated-with-acute-phase-response-of-bisphosphonate-na%C3%A3-ve-or-pretreated-women-with-osteoporosis-receiving-an-intravenous-first-dose-of-zoledronate-or-ibandronate
#9
A W Popp, R Senn, I Curkovic, C Senn, H Buffat, P F Popp, K Lippuner
A first intravenous dose of bisphosphonates may be associated with an acute-phase response (APR). In bisphosphonate-naïve women with postmenopausal osteoporosis, the characteristics and frequency of APR may differ by compound. Prior bisphosphonate exposure was predictive of APR risk and severity. INTRODUCTION: Intravenous (IV) administration of bisphosphonates (BP), such as zoledronate (ZOL) and ibandronate (IBN), may be associated with an APR. The characteristics of APR may differ by compound...
March 15, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28295822/anterior-rectus-sheath-blocks-in-children-with-abdominal-wall-pain-due-to-anterior-cutaneous-nerve-entrapment-syndrome-a-prospective-case-series-of-85-children
#10
Murid Siawash, Frederique Mol, Walther Tjon-A-Ten, Christel Perquin, Percy van Eerten, Ernst van Heurn, Rudi Roumen, Marc Scheltinga
BACKGROUND: Chronic abdominal pain in children may be caused by the anterior cutaneous nerve entrapment syndrome. Local nerve blocks are recommended as an initial treatment in adults. Evidence on effectiveness and safety of such a treatment in children is lacking. AIM: Our aim was to study outcome and adverse events of anterior rectus sheath blocks in childhood anterior cutaneous nerve entrapment syndrome. METHODS: Patients <18 years of age receiving anterior rectus sheath blocks were prospectively followed...
March 10, 2017: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/28288074/racial-differences-and-disparities-in-osteoporosis-related-bone-health-results-from-the-paadrn-randomized-controlled-trial
#11
Peter Cram, Kenneth G Saag, Yiyue Lou, Stephanie W Edmonds, Sylvie F Hall, Douglas W Roblin, Nicole C Wright, Michael P Jones, Fredric D Wolinsky
BACKGROUND: Determining whether observed differences in health care can be called disparities requires persistence of differences after adjustment for relevant patient, provider, and health system factors. We examined whether providing dual-energy x-ray absorptiometry (DXA) test results directly to patients might reduce or eliminate racial differences in osteoporosis-related health care. DESIGN, SUBJECTS, AND MEASURES: We analyzed data from 3484 white and 1041 black women who underwent DXA testing at 2 health systems participating in the Patient Activation after DXA Result Notification (PAADRN) pragmatic clinical trial (ClinicalTrials...
March 10, 2017: Medical Care
https://www.readbyqxmd.com/read/28283374/outcomes-after-a-left-anterior-descending-artery-endarterectomy-in-advanced-coronary-artery-disease
#12
Charalampos Katselis, George Samanidis, Anastasia Papasotiriou, George Karatasakis, Ioannis Nenekidis, Eftichia Demerouti, Theofani Antoniou, Konstantinos Perreas
BACKGROUND: Coronary endarterectomy albeit infrequently utilized remains a pivotal treatment modality for advanced atherosclerotic heart disease. Benefits of coronary endarterectomy are explored in terms of better mid-term survival, freedom of major adverse cardiac and cerebrovascular events and improved left ventricular ejection fraction. METHODS: 50 patients with coronary artery disease including extensive diffuse LAD disease underwent a left anterior descending artery endarterectomy with coronary by-pass grafting and left internal mammary artery as conduit between 2006 and 2014...
February 21, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/28279749/how-to-diagnose-an-acutely-inflamed-appendix-a-systematic-review-of-the-latest-evidence
#13
REVIEW
S A Kabir, S I Kabir, R Sun, Sadaf Jafferbhoy, Ahmed Karim
Acute appendicitis is the most common condition that presents with an acute abdomen needing emergency surgery. Despite this common presentation, correctly diagnosing appendicitis remains a challenge as clinical signs or positive blood results can be absent in 55% of the patients. The reported proportion of missed diagnoses of appendicitis ranges between 20% and 40%. A delay or mis-diagnosis of appendicitis can result in severe complications such as perforation, abscess formation, sepsis, and intra-abdominal adhesions...
March 6, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28275638/epigenomic-data-facilitate-genetic-studies-for-osteoporosis-in-post-gwas-era
#14
Yan Guo, Shan-Shan Dong, Tie-Lin Yang
No abstract text is available yet for this article.
February 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28274051/effectiveness-of-two-topical-anaesthetic-agents-used-along-with-audio-visual-aids-in-paediatric-dental-patients
#15
Nidhi Agarwal, Jayata Dhawan, Dipanshu Kumar, Ashish Anand, Karan Tangri
INTRODUCTION: Topical anaesthetic agents enable pain free intraoral procedures, symptomatic pain relief for toothache, superficial mucosal lesions and pain related to post extraction time. Most common anxiety provoking and fearful experience for children in dental operatory is administration of local anaesthesia because on seeing the needle, children usually become uncooperative. One of recent trend of behaviour management technique is using non-aversive techniques out of which audiovisual distraction has emerged as a very successful technique for managing children in dental settings...
January 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28267076/antimalarial-prescription-in-a-public-hospital-outpatient-setting-in-kenya-a-best-practice-implementation-project
#16
Henry K Amdany, Mark McMillan, Peninah Kiptoo
BACKGROUND: Important gaps still exist in malaria case management despite implementation of the World Health Organization parasitological diagnosis before treatment recommendation. This calls for evidence-based strategies to improve health providers' adherence to these guidelines. OBJECTIVE: The goal of this project was to improve adherence of confirmed parasitological diagnosis prior to antimalarial prescription in the outpatient department. METHODS: The Joanna Briggs Institute Practical Application of Clinical Evidence System program was used to facilitate collection of baseline and post-audit data...
March 2017: International Journal of Evidence-based Healthcare
https://www.readbyqxmd.com/read/28263226/age-adjusted-alignment-goals-have-the-potential-to-reduce-pjk
#17
Renaud Lafage, Frank Schwab, Steve Glassman, Shay Bess, Bradley Harris, Justin Sheer, Robert Hart, Breton Line, Jensen Henry, Doug Burton, HanJo Kim, Eric Klineberg, Christopher Ames, Virginie Lafage
STUDY DESIGN: Retrospective cohort OBJECTIVE.: To explore proximal junctional kyphosis(PJK) as a function of age-adjusted surgical correction goals. SUMMARY OF BACKGROUND DATA: Recent adult spinal deformity(ASD) studies show that alignment targets are age-specific. Despite recognizing age and malalignment as PJK risk factors, no study has assessed the age-specific effects of alignment on PJK. METHODS: ASD patients with fusions to the pelvis were included and stratified into three groups: young adults(YA<40yo), middle aged(MA: 40-65yo), the elderly(ED>65yo)...
March 3, 2017: Spine
https://www.readbyqxmd.com/read/28262724/comparison-of-bone-mineral-loss-by-combined-androgen-block-agonist-versus-gnrh-in-patients-with-prostate-cancer-a-12-month-prospective-observational-study
#18
Sung Han Kim, Jae Young Joung, Sohee Kim, Koon Ho Rha, Hyeong Gon Kim, Cheol Kwak, Ji Youl Lee, Seong Soo Jeon, Sung Kyu Hong, Hyeon Jeong, Moon Ki Jo, Dalsan You, In Gab Jeong, Jun Hyuk Hong, Choung-Soo Kim
The multi-centre, prospective, observational study was designed to examine the efficacy of continuous combined androgen block (CAB) vs. GnRH agonist monotherapy in terms of bone mineral density (BMD) change during 12 months post-androgen deprivation therapy (ADT) in Asian prostate cancer patients. Multiple regression analysis and estimated the 10-year probability of major fractures among the patients with Fracture Risk Assessment Tool were conducted to investigate the underlying factors affecting BMD. Paired t-test to evaluate the change of BMD from baseline to 12 month, and two sample t-test to examine the difference of BMD changes were used between two groups...
March 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28261929/association-of-collagen-type-i-alpha-1-1245g-t-polymorphism-and-osteoporosis-risk-in-post-menopausal-women-a-meta-analysis
#19
Jian Wu, Meng Yu, Yixin Zhou
AIM: To fully understand the association between collagen type I alpha 1 (COL1A1) +1245G/T polymorphism and osteoporosis risk in post-menopausal women. METHODS: We searched the electronic databases including PubMed, Embase and Cochrane library updated to January 2016, as well as printed articles. Studies were screened according to the predefined inclusion and exclusion criteria, and the included studies were further assessed by Clark scores system. Furthermore, the association between COL1A1 +1245G/T polymorphism and osteoporosis risk was assessed using odds ratios (ORs) and their 95% confidence intervals (95% CIs)...
March 5, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28260003/estrogen-stimulates-osteoprotegerin-expression-via-the-suppression-of-mir-145-expression-in-mg-63-cells
#20
Jun Jia, Hengxing Zhou, Xiantie Zeng, Shiqing Feng
Osteoprotegerin (OPG) is implicated in the pathogenesis of postmenopausal osteoporosis, and other metabolic bone diseases caused by estrogen deficiency. Previous studies have demonstrated that estrogen may stimulate OPG expression in osteoblast cells at the transcriptional level; however, whether estrogen can regulate OPG expression at a post-transcriptional level remains elusive. The present study aimed to investigate the role of microRNA (miRNA) in estrogen‑mediated OPG production in human osteoblast‑like MG‑63 cells...
February 6, 2017: Molecular Medicine Reports
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