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https://www.readbyqxmd.com/read/28812252/secondary-fracture-prevention-in-hip-fracture-patients-requires-cooperation-from-general-practitioners
#1
Jan Vaculík, Jan J Stepan, Pavel Dungl, Marek Majerníček, Alexander Čelko, Valér Džupa
Despite individual recommendations on osteoporosis management in patients after hip fracture surgery, addressed by orthopedic surgeons to Czech general practitioners, the patients remained undiagnosed and untreated because of provider-level barriers to post-fracture secondary prevention. PURPOSE: The goal of the study was to assess whether an individual recommendation on osteoporosis treatment addressed to a hip fracture patient's GP would lead to better osteoporosis management. METHODS: Two groups of patients who suffered hip fractures and were treated at the Orthopedic Department were evaluated...
May 18, 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/28811765/regression-of-right-ventricular-systolic-pressure-after-successful-percutaneous-mitral-commissurotomy-in-patients-with-isolated-severe-mitral-stenosis
#2
Shah Zeb, Tariq Ashraf, Muhammad Hashim, Syed Nadeem Hassan Rizvi
OBJECTIVE: To know the regression of right ventricular pressure after successful percutaneous transluminalmitral commissurotomy (PTMC) in patients with severe isolated mitral stenosis. METHODS: This descriptive study was performed in inpatient and outpatient department of National Institute of Cardiovascular Disease from 1(st) February 2016 to 31(st) August 2016. Echocardiography of all patients with successful PTMC were recorded 24 hours and 06 months following PTMC to see for Regression of right ventricular pressure along with other baseline echocardiographic parameters...
May 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28811684/lead-as-a-risk-factor-for-osteoporosis-in-post-menopausal-women
#3
REVIEW
Anjali Manocha, L M Srivastava, Seema Bhargava
Lead exposure is increasingly becoming an important risk factor for osteoporosis. In adults, approximately 80-90 % of absorbed lead is stored in the bones. These bone lead deposits are released into the blood during periods of enhanced bone resorption like menopause, forming a potential endogenous source of lead exposure. Postmenopausal women are at a higher risk for bone lead release because of hormonal and age related changes in bone metabolism. Estrogen deficiency is associated with increase in osteoclasts number and activity leading to both the early and late form of osteoporosis...
July 2017: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/28811200/globular-adiponectin-reverses-osteo-sarcopenia-and-altered-body-composition-in-ovariectomized-rats
#4
Shyamsundar Pal China, Subhashis Pal, Sourav Chattopadhyay, Konica Porwal, Sapana Kushwaha, Sharmishtha Bhattacharyya, Monika Mittal, Anagha A Gurjar, Tarun Barbhuyan, Abhishek K Singh, Arun K Trivedi, Jiaur R Gayen, Sabyasachi Sanyal, Naibedya Chattopadhyay
Adiponectin regulates various metabolic processes including glucose flux, lipid breakdown and insulin response. We recently reported that adiponectin receptor1 (adipoR1) activation by a small molecule reverses osteopenia in leptin receptor deficient db/db (diabetic) mice. However, the role of adiponectin in bone metabolism under the setting of post-menopausal (estrogen-deficiency) osteopenia and associated metabolic derangements has not been studied. Here, we studied the therapeutic effect of the globular form of adiponectin (gAd), which is predominantly an adipoR1 agonist, in aged ovariectomized (OVX) rats and compared it with standard-of-care anti-osteoporosis drugs...
August 12, 2017: Bone
https://www.readbyqxmd.com/read/28810653/surgical-trauma-and-low-dose-methylprednisolone-modulate-the-severity-of-the-acute-phase-response-induced-by-zoledronic-acid-infusion
#5
Jian Chen, Lipeng Yu, Lixin Chen, Xuan Wu, Pengyu Tang, Jian Yin, Tao Jiang, Guoyong Yin, Jin Fan
The aim of the present study was to investigate risk factors for the development of an acute-phase response (APR) associated with the initial zoledronic acid (ZA) infusion in patients undergoing surgery, and to assess whether its onset may be reduced by post-dose administration of low-dose methylprednisolone (MP) or acetaminophen. A retrospective study of patients with osteoporosis who attended the departments of orthopedics and endocrinology of a single hospital and received 5 mg ZA was conducted; the patients included surgical and non-surgical cases...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28809431/transdifferentiation-of-myoblasts-into-osteoblasts-possible-use-for-bone-therapy
#6
REVIEW
Daphne P L Lin, Revathy Carnagarin, Arun Dharmarajan, Crispin R Dass
OBJECTIVES: Transdifferentiation is defined as the conversion of one cell type to another and is an ever-expanding field with a growing number of cells found to be capable of such a process. To date, the fact remains that there are limited treatment options for fracture healing, osteoporosis and bone repair post-destruction by bone tumours. Hence, this review focuses on the transdifferentiation of myoblast to osteoblast as a means to further understand the transdifferentiation process and to investigate a potential therapeutic option if successful...
August 15, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28808371/efficacy-of-osteopathic-manipulative-treatment-approach-in-the-patient-with-pulmonary-fibrosis-in-critical-care-outpatient-department
#7
Manu Goyal, Kanu Goyal, Kanimozhi Narkeesh, Asir John Samuel, Narkeesh Arumugam, Subhasish Chatterjee, Sorabh Sharma
The purpose of the present case study was to explore the efficacy of osteopathic manipulative treatment (OMT) in patient with pulmonary fibrosis (PF) in the critical care outpatient department. Here, we present a 48-year-old male case with breathlessness, increased frequency of defecation, and pain in and around the nape of neck with diagnosed pulmonary fibrosis. He scored 3 on a patient-reported modified Medical Research Council (mMRC) dyspnea scale. Osteopathic examination reveals multiple somatic findings across the chest and abdominal region and treated by OMT...
July 2017: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/28806285/peritoneal-cavity-lavage-reduces-the-presence-of-mitochondrial-damage-associated-molecular-patterns-in-open-abdomen-patients
#8
Patricia Angellice Martinez-Quinones, Cameron Grant McCarthy, Caleb J Mentzer, Camilla Ferreira Wenceslau, Steven Barry Holsten, R Clinton Webb, Keith O'Malley
BACKGROUND: Mitochondrial damage-associated molecular patterns (mtDAMPs), such as mitochondrial DNA and N-formylated peptides, are endogenous molecules released from tissue after traumatic injury. mtDAMPs are potent activators of the innate immune system. They have similarities with bacteria, which allow mtDAMPs to interact with the same pattern recognition receptors and mediate the development of Systemic Inflammatory Response Syndrome (SIRS). Current recommendations for management of an open abdomen include returning to the operating room every 48 hours for peritoneal cavity lavage until definitive procedure...
August 12, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28805705/changes-of-bone-related-minerals-during-denosumab-administration-in-post-menopausal-osteoporotic-patients
#9
Takako Suzuki, Yukio Nakamura, Hiroyuki Kato
OBJECTIVES: This retrospective study included 21 patients with primary osteoporosis who were treated with the anti-resorption drug, denosumab. To date, there has been no detailed report on the changes of bone-related minerals after anti-resorption drug therapy. METHODS: Twenty-one post-menopausal females were retrospectively enrolled. Serum zinc (Zn), magnesium (Mg), iron (Fe), copper (Cu), grip strength, and estimated glomerular filtration rate (eGFR) were examined at one week and 1, 2, 4, 6, 8, 10, and 12 months...
August 13, 2017: Nutrients
https://www.readbyqxmd.com/read/28794136/neutrophil-gelatinase-associated-lipocalin-prior-to-cardiac-surgery-predicts-acute-kidney-injury-and-mortality
#10
Heerajnarain Bulluck, Raju Maiti, Bibhas Chakraborty, Luciano Candilio, Tim Clayton, Richard Evans, David P Jenkins, Shyam Kolvekar, Gudrun Kunst, Christopher Laing, Jennifer Nicholas, John Pepper, Derek M Yellon, Derek J Hausenloy
OBJECTIVE: We aimed to investigate whether preoperative serum neutrophil gelatinase-associated lipocalin (sNGALpre-op) predicted postoperative acute kidney injury (AKI) during hospitalisation and 1-year cardiovascular and all-cause mortality following adult cardiac surgery. METHODS: This study was a post hoc analysis of the Effect of Remote Ischemic Preconditioning on Clinical Outcomes in Patient Undergoing Coronary Artery Bypass Graft Surgery trial involving adult patients undergoing coronary artery bypass graft...
August 9, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28793827/kiwi-omnicup-handheld-vs-mityvac-m-style-conventional-vacuum-system-a-retrospective-observational-study
#11
Tal Weissbach, Nasreen Hag-Yahia, Michal Ovadia, Keren Tzadikevitch Geffen, Omer Weitzner, Tal Biron-Shental
INTRODUCTION: To improve choice of vacuum-assisted delivery (VAD) system, we compared outcomes of Kiwi handheld system and Mityvac M-style conventional system (both use disposable plastic cups). MATERIALS AND METHODS: Retrospective observational study with data collection from electronic medical records. The study was conducted at a tertiary medical center, with approximately 7000 deliveries annually. Categorical and continuous variables were analyzed using chi-square test and t-test, respectively...
August 9, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28789921/discontinuation-of-denosumab-therapy-for-osteoporosis-a-systematic-review-and-position-statement-by-ects
#12
REVIEW
Elena Tsourdi, Bente Langdahl, Martine Cohen-Solal, Bérengere Aubry-Rozier, Erik Fink Eriksen, Nuria Guañabens, Barbara Obermayer-Pietsch, Stuart H Ralston, Richard Eastell, M Carola Zillikens
INTRODUCTION: The optimal duration of osteoporosis treatment is controversial. As opposed to bisphosphonates, denosumab does not incorporate into bone matrix and bone turnover is not suppressed after its cessation. Recent reports imply that denosumab discontinuation may lead to an increased risk of multiple vertebral fractures. METHODS: The European Calcified Tissue Society (ECTS) formed a working group to perform a systematic review of existing literature on the effects of stopping denosumab and provide advice on management...
August 5, 2017: Bone
https://www.readbyqxmd.com/read/28777716/research-priorities-in-subspecialty-palliative-care-policy-initiatives
#13
Lynn F Reinke, Diane E Meier
Palliative care demonstrably improves quality of life for the seriously ill in a manner that averts preventable health crises and their associated costs. Because of these outcomes, palliative care is now broadening its reach beyond hospitals, and hospice care for those near death, to patients and their families living in the community with chronic multimorbidities that have uncertain or long expected survival. In this article, we address research needed to enable policies supportive of palliative care access and quality, including changes in regulatory, accreditation, financing, and training approaches in the purview of policy makers...
August 2017: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/28775273/calcium-and-vitamin-d-deficiency-marginally-impairs-fracture-healing-but-aggravates-posttraumatic-bone-loss-in-osteoporotic-mice
#14
Verena Fischer, Melanie Haffner-Luntzer, Katja Prystaz, Annika Vom Scheidt, Björn Busse, Thorsten Schinke, Michael Amling, Anita Ignatius
Calcium and vitamin-D (Ca/VitD) deficiency is a major risk factor for osteoporosis. It may also contribute to the compromised bone healing frequently observed in osteoporotic patients, since calcium is essential for fracture-callus mineralization. Additionally, clinical data suggest systemic bone loss following fracture, which may aggravate osteoporosis and thus increase the risk for fragility fractures in osteoporotic patients further. However, the role of Ca/VitD in fracture healing and posttraumatic bone turnover has to date been poorly investigated...
August 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28767626/a-detailed-comparative-analysis-of-anterior-versus-posterior-approach-to-lenke-5c-curves
#15
Firoz Miyanji, Luigi A Nasto, Tracey Bastrom, Amer F Samdani, Burt Yaszay, David Clements, Suken A Shah, Baron Lonner, Randal R Betz, Harry L Shufflebarger, Peter O Newton
STUDY DESIGN: Prospective cohort study OBJECTIVE.: To prospectively compare radiographic, perioperative and functional outcomes between anterior spinal instrumented fusion (ASIF) and posterior spinal instrumented fusion (PSIF) in Lenke 5C curves. SUMMARY OF BACKGROUND DATA: Historically, ASIF has been the treatment of choice for treatment of thoracolumbar adolescent idiopathic scoliosis (AIS). More recently, PSIF has gained popularity for its ease, versatility and amount of correction achieved...
August 1, 2017: Spine
https://www.readbyqxmd.com/read/28765797/radiographic-analysis-of-cervical-and-spinal-alignment-in-multilevel-acdf-with-lordotic-interbody-device
#16
Yoshihiro Katsuura, Alex Lemons, Eileen Lorenz, Rachel Swafford, James Osborn, Garrick Cason
BACKGROUND: Restoration and maintenance of cervical lordosis is an important clinical parameter in spine surgery. The purpose of this study was to determine the extent to which a multilevel anterior cervical discectomy and fusion (ACDF: greater than 3 levels) procedure restores cervical lordosis and the affect of increasing lordosis on sagittal vertical axis. METHODS: We performed a retrospective radiographic analysis of 69 patients who underwent multilevel ACDF by 2 surgeons between 2013 and 2014...
2017: International Journal of Spine Surgery
https://www.readbyqxmd.com/read/28765796/the-effects-of-topical-vancomycin-on-mesenchymal-stem-cells-more-may-not-be-better
#17
Stacey Chu, Nita Chen, Alexis B C Dang, Alfred C Kuo, Alan B C Dang
BACKGROUND: The use of topical vancomycin is increasingly popular in spine surgery. Large retrospective reviews suggest that topical vancomycin provides a cost-effective decrease in post-operative infection. Currently, there is little that is known about the maximum dose that can be applied locally. When 1 gram of vancomycin is mixed into the bone graft and another 1 gram applied freely in a spine wound, the local concentration of antibiotic ranges from 260-2900 μg/mL in the immediate post-op period and 50-730 μg/mL by the second post-operative day...
2017: International Journal of Spine Surgery
https://www.readbyqxmd.com/read/28765269/the-efficacy-and-safety-of-vertebral-fracture-prevention-therapies-in-post-menopausal-osteoporosis-treatment-which-therapies-work-best-a-network-meta-analysis
#18
G Wang, L Sui, P Gai, G Li, X Qi, X Jiang
OBJECTIVES: Osteoporosis has become an increasing concern for older people as it may potentially lead to osteoporotic fractures. This study is designed to assess the efficacy and safety of ten therapies for post-menopausal women using network meta-analysis. METHODS: We conducted a systematic search in several databases, including PubMed and Embase. A random-effects model was employed and results were assessed by the odds ratio (OR) and corresponding 95% confidence intervals (CI)...
July 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28762021/retroverted-glenoid-reconstruction-using-glenoid-plate-in-reverse-shoulder-arthroplasty
#19
R Lanzone, S Carbone, P Albino, J-B Cassio, P Métais
PURPOSE: The objective of this study is to evaluate the clinical and radiological results of reverse shoulder arthroplasty (RSA) with glenoid plating in a consecutive series of patients affected by cuff tear glenohumeral arthropathy with glenoid retroversion >15°. We hypothesized that autologous humeral head graft may be better stabilized between the baseplate and the native glenoid surface with the use of a glenoid plate. METHODS: Twenty consecutive patients affected by cuff tear arthropathy with glenoid retroversion >15° (B2 or C according to Walch classification) were enrolled in this study...
July 31, 2017: Musculoskeletal Surgery
https://www.readbyqxmd.com/read/28756709/emerging-anabolic-agents-in-the-treatment-of-osteoporosis
#20
Christina Lovato, E Michael Lewiecki
Osteoporosis is a common skeletal disease with serious consequences due to osteoporotic fractures and high costs to society for post-fracture care. Most patients at high risk for fracture are not receiving care to reduce fracture risk. The osteoporosis treatment gap has reached crisis proportions. Strategies to reduce the treatment gap include systematic methods for identifying and treating high risk patients, better education of patients and healthcare providers, better use of currently available drugs, and development of new drugs to treat osteoporosis...
July 31, 2017: Expert Opinion on Emerging Drugs
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