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https://www.readbyqxmd.com/read/28643048/association-of-gastrointestinal-events-with-quality-of-life-and-treatment-satisfaction-in-osteoporosis-patients-results-from-the-medication-use-patterns-treatment-satisfaction-and-inadequate-control-of-osteoporosis-study-music-os
#1
A Modi, S Sen, J D Adachi, S Adami, B Cortet, A L Cooper, P Geusens, D Mellström, J P Weaver, J P van den Bergh, P A Keown, S Sajjan
The purpose of this study was to assess the association of GI events with HRQoL and treatment satisfaction. The effect of baseline GI events persisted through 1 year of follow-up, as indicated by lower EQ-5D, OPAQ-SV, and treatment satisfaction scores among patients with vs without baseline GI events. The presence of GI events is an independent predictor of decreased HRQoL and treatment satisfaction in patients being treated for osteoporosis. INTRODUCTION: The goal of this study was to assess the association of gastrointestinal (GI) events with health-related quality of life (HRQoL) and treatment satisfaction in patients being treated for osteoporosis...
June 22, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28641216/psychoeducational-groups-for-adults-with-adhd-and-their-significant-others-pegasus-a-pragmatic-multicenter-and-randomized-controlled-trial
#2
T Hirvikoski, T Lindström, J Carlsson, E Waaler, J Jokinen, S Bölte
OBJECTIVE: To examine the feasibility, efficacy, and effectiveness of PEGASUS, a group-based structured psychoeducation for adults with ADHD and their significant others. METHOD: A pragmatic parallel group add-on design multicenter randomized controlled trial was conducted, comparing an 8-session treatment with PEGASUS (allocated n=97; 48 with ADHD and 49 with significant others) to treatment as usual (TAU, allocated n=82; 39 with ADHD and 43 significant others)...
May 9, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28639157/exercise-for-improving-bone-health-in-women-treated-for-stages-i-iii-breast-cancer-a-systematic-review-and-meta-analyses
#3
REVIEW
Canan P Fornusek, Sharon L Kilbreath
PURPOSE: The purpose of this study was to evaluate the efficacy of exercise, either alone or in combination with other interventions, compared to a control, for the preservation of bone mineral density (BMD) in early breast cancer (BC) patients. METHODS: A systematic search was conducted to identify randomized or quasi-randomized trials which met inclusion criteria including prescribed exercise for ≥12 months. Ten publications from seven randomized controlled trials (RCTs), involving 1199 participants, were identified...
June 21, 2017: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/28638864/protective-effect-of-vanillic-acid-on-ovariectomy-induced-osteoporosis-in-rats
#4
Yong Gui Wang, Liang Bo Jiang, Bo Gou
BACKGROUND: The need for an anti-osteoporotic agent is in high demand since osteoporosis contributes to high rates of disability or impairment (high osteoporotic fracture), morbidity and mortality. Hence, the present study is designed to evaluate the protective effects of vanillic acid (VA) against bilateral ovariectomy-induced osteoporosis in female Sprague-Dawley (SD) rats. MATERIALS AND METHODS: Forty healthy female adult SD rats were separated in to four groups with sham-operated control with bilateral laprotomy (Sham; n = 10), bilateral overiectomy (OVX; n = 10) group, OVX rats were orallay administrated with 50 mg/kg b...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28637283/an-essential-physiological-role-for-mct8-in-bone-in-male-mice
#5
Victoria D Leitch, Caterina Di Cosmo, Xiao-Hui Liao, Sam O'Boy, Thomas M Galliford, Holly Evans, Peter I Croucher, Alan Boyde, Alexandra Dumitrescu, Roy E Weiss, Samuel Refetoff, Graham R Williams, J H Duncan Bassett
T3 is an important regulator of skeletal development and adult bone maintenance. Thyroid hormone action requires efficient transport of T4 and T3 into target cells. We hypothesized that monocarboxylate transporter-8, encoded by Mct8 on the X-chromosome, is an essential thyroid hormone transporter in bone. To test this hypothesis, we determined the juvenile and adult skeletal phenotypes of male Mct8 knockout mice (Mct8KO) and Mct8D1D2KO compound mutants, which additionally lack the ability to convert the prohormone T4 to the active hormone T3...
June 15, 2017: Endocrinology
https://www.readbyqxmd.com/read/28632644/do-former-smokers-exhibit-a-distinct-profile-before-and-after-lumbar-spine-surgery
#6
Ehsan Jazini, Steven D Glassman, Erica F Bisson, Eric A Potts, Leah Y Carreon
STUDY DESIGN: Retrospective longitudinal cohort OBJECTIVES.: To determine if former smokers undergoing lumbar spine surgery have distinct baseline and post-operative Patient Reported Outcomes (PROs) compared to never smokers and current smokers SUMMARY OF BACKGROUND DATA.: Smoking has known deleterious effects on patients undergoing lumbar spine surgery. However, former smokers have not been extensively evaluated. There are few studies regarding the relationship between pack-years or duration of smoking cessation, and subsequent clinical outcome...
June 19, 2017: Spine
https://www.readbyqxmd.com/read/28627474/sox9-positive-periosteal-cells-in-fracture-repair-of-the-adult-mammalian-long-bone
#7
Xinjun He, Sofia Bougioukli, Brandon Ortega, Eric Arevalo, Jay R Lieberman, Andrew P McMahon
INTRODUCTION: The phases of fracture healing have been well characterized. However, the exact source and genetic profile of the skeletal progenitors that participate in bone repair is somewhat unclear. Sox9 expression in skeletal elements precedes bone and cartilage formation and a Sox9(+) cell type is retained in the adult periosteum. We hypothesized that Sox9(+) periosteal cells are multipotent skeletal progenitors normally participating in fracture repair. METHODS: To test this hypothesis we used tamoxifen (TM)-mediated lineage tracing of Sox9(+) cells in Sox9CreErt2:Td-Tomato mice...
June 13, 2017: Bone
https://www.readbyqxmd.com/read/28626818/astigmatic-treatment-with-photorefractive-keratectomy-investigations-of%C3%A2-non-keratometric-ocular-astigmatism
#8
Alireza Peyman, Zahra Dastborhan, Mohammadreza Peyman
PURPOSE: To evaluate the effect of non-keratometric ocular astigmatisms on visual and refractive outcomes after photorefractive keratectomy (PRK) for correction of myopic astigmatisms. METHODS: Seventy one eyes of 36 subjects were enrolled in this study. Patients underwent PRK for treatment of myopia. Subjects were evaluated for refractive error, keratometry, and visual acuity before and six months after surgery. Pre- and post-op non-keratometric astigmatisms were calculated by vectorial analysis of the difference between the corneal plane refractive astigmatism and keratometric astigmatism...
June 2017: Journal of Current Ophthalmology
https://www.readbyqxmd.com/read/28625096/surgical-technique-and-early-outcomes-of-intramedullary-nailing-of-displaced-proximal-humeral-fractures-in-an-asian-population-using-a-contemporary-straight-nail-design
#9
Toon Dong Hao, Andy Wee Teck Huat
BACKGROUND: Despite being a common orthopedic injury, the optimal management of proximal humeral fractures remains a topic of debate. Although intramedullary nails have been used to treat these fractures, several complications have been reported with older nail devices. We describe our surgical technique and aim to evaluate the early functional and radiological outcomes of displaced Neer's two- to four-part proximal humeral fractures undergoing fixation with a contemporary straight intramedullary nail...
May 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/28624656/strontium-and-cobalt-substituted-bioactive-glasses-seeded-with-human-umbilical-cord-perivascular-cells-to-promote-bone-regeneration-via-enhanced-osteogenic-and-angiogenic-activities
#10
Saeid Kargozar, Nasrin Lotfibakhshaiesh, Jafar Ai, Masoud Mozafari, Peiman Brouki Milan, Sepideh Hamzehlou, Mahmoud Barati, Francesco Baino, Robert G Hill, Mohammad Taghi Joghataei
Designing and developing new biomaterials to accelerate bone healing are currently under progress. In this study, we attempted to promote osteogenesis using strontium- and cobalt- substituted bioactive glasses (BGs) seeded with human umbilical cord perivascular cells (HUCPVCs) in a critical size defect in the distal femur of rabbit animal model. The BG particles were successfully synthesized in the form of granules using the melt-derived route. After being isolated, HUCPVCs were expanded and then characterized to use during in vitro and in vivo procedures...
June 14, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28612149/35-year-experience-with-surgical-treatment-of-hidradenitis-suppurativa
#11
Richard E Burney
BACKGROUND: Hidradenitis suppurativa is a painful and disfiguring chronic inflammatory condition affecting both men and women. Medical treatments, such as antibiotics and immunosuppressive agents, are often ineffective. Over time, patients can suffer from recurrent abscesses, chronic purulent drainage, scarring, and contractures that can only be corrected by surgical excision. There is no agreement, however, on the best way for the surgeon to manage this condition. The purpose of this review is to describe the results of surgical treatment of this condition in a large cohort of patients managed by local excision of hidradenitis, healing by secondary intention and reoperation as needed...
June 13, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28607900/impaired-vestibular-function-after-cochlear-implantation-in-children-role-of-static-posturography
#12
Satish Nair, Atul Gupta, Ajith Nilakantan, Ruchika Mittal, Ruchi Dahiya, Sachin Saini, Rachana Prasad, Deepika Vajpayee
To identify vestibular dysfunction in children after cochlear implant surgery and to study the utility of static posturography in evaluating vestibular function in children. A prospective study was carried out on 25 children between 2 and 7 years of age with sensorineural hearing loss with no overt vestibular dysfunction. All children underwent static posturography using Synapsis Posturographic System (SPS) software (Version 3.0, REV C) using a static platform with foam. The centre of pressure (COP) shift was recorded as statokinesiogram on the software and the mean vestibular, visual and somesthetic scores were obtained...
June 2017: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/28607522/agreement-between-fragility-fracture-risk-assessment-algorithms-as-applied-to-adults-with-chronic-spinal-cord-injury
#13
T Cervinka, C L Lynch, L Giangregorio, J D Adachi, A Papaioannou, L Thabane, B C Craven
STUDY DESIGN: Cross-sectional. OBJECTIVES: The objective of the study was to determine and report agreement in fracture risk stratification of adults with spinal cord injury (SCI) using (1) Canadian Association of Radiologists and Osteoporosis Canada (CAROC) and Canadian Fracture Risk Assessment (FRAX) tools with and without areal bone mineral density (aBMD) and (2) SCI-specific fracture thresholds. SETTING: Tertiary rehabilitation center, Ontario, Canada...
June 13, 2017: Spinal Cord
https://www.readbyqxmd.com/read/28606496/emotional-distress-as-a-predictor-of-statin-non-adherence-among-swedish-first-time-myocardial-infarction-patients-2006-2013
#14
C T Lissåker, J Wallert, C Held, E Olsson
BACKGROUND: Emotional distress (depression and anxiety) has been known to affect mortality after a myocardial infarction (MI). One possible mechanism is through medication non-adherence. Few studies have investigated the link between statin adherence and emotional distress, and results are not consistent. We aimed to explore whether emotional distress affects adherence among first-time MI patients younger than 75years old receiving a prescription for the first time. METHODS: We identified first-MI individuals younger than 75years from the SWEDEHEART national quality registers discharged with a statin prescription...
June 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28603552/problem-management-plus-pm-in-the-management-of-common-mental-disorders-in-a-specialized-mental-healthcare-facility-in-pakistan-study-protocol-for-a-randomized-controlled-trial
#15
Syed Usman Hamdani, Zainab Ahmed, Marit Sijbrandij, Huma Nazir, Aqsa Masood, Parveen Akhtar, Hania Amin, Richard A Bryant, Katie Dawson, Mark van Ommeren, Atif Rahman, Fareed Aslam Minhas
BACKGROUND: The World Health Organization (WHO) has developed Problem Management Plus (PM+), a 5-session, psychological intervention program delivered by trained non-specialist that addresses common mental disorders. The objectives of this study are to evaluate effectiveness and cost-effectiveness of PM+ in a specialized mental health care facility in Pakistan. METHODS: A single blind individual randomized controlled trial (RCT) will be carried out in the outpatient department of a specialized mental healthcare facility in Rawalpindi, Pakistan...
2017: International Journal of Mental Health Systems
https://www.readbyqxmd.com/read/28598385/the-roles-of-long-non-protein-coding-rnas-in-osteo-adipogenic-lineage-commitment
#16
REVIEW
Hirotaka Yoshioka, Yuji Yoshiko
Osteoblasts and adipocytes share a common mesenchymal progenitor in the bone marrow. This implies that a reciprocal relationship exists between osteogenic and adipogenic differentiation. Further, cells of osteoblast lineage transdifferentiate into adipocytes under some circumstances. Dysregulation of osteo-adipogenic fate-determination leads to bone diseases such as osteoporosis, accompanied by an increase in bone marrow adipose tissue. Thus, the fine-tuning of osteo-adipogenesis is necessary for bone homeostasis...
June 9, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28591887/accuracy-of-high-field-intraoperative-mri-in-the-detectability-of-residual-tumor-in-glioma-grade-iv-resections
#17
Volker Heßelmann, Ann-Kathrin Mager, Claudia Goetz, Oliver Detsch, Hannah-Katharina Theisgen, Michael Friese, Wolfram Schwindt, Joachim Gottschalk, Paul Kremer
Objective To assess the sensitivity/specificity of tumor detection by T1 contrast enhancement in intraoperative MRI (ioMRI) in comparison to histopathological assessment as the gold standard in patients receiving surgical resection of grade IV glioblastoma. Materials and Methods 68 patients with a primary or a recurrent glioblastoma scheduled for surgery including fluorescence guidance and neuronavigation were included (mean age: 59 years, 26 female, 42 male patients). The ioMRI after the first resection included transverse FLAIR, DWI, T2-FFE and T1 - 3 d FFE +/- GD-DPTA...
June 2017: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/28589380/persistence-with-denosumab-therapy-in-women-affected-by-osteoporosis-with-fragility-fractures-a-multicenter-observational-real-practice-study-in-italy
#18
S Migliaccio, D Francomano, E Romagnoli, C Marocco, R Fornari, G Resmini, A Buffa, G Di Pietro, S Corvaglia, F Gimigliano, A Moretti, A de Sire, N Malavolta, A Lenzi, E A Greco, G Iolascon
BACKGROUND: Persistence is commonly considered a key factor for the successful management of osteoporosis and fragility fractures. Denosumab is the first biologic agent developed for the treatment of osteoporosis with satisfying data regarding the persistence with this therapy. AIM: The purpose of this multicenter observational real practice study was to evaluate the persistence with denosumab treatment in post-menopausal women affected by osteoporosis. MATERIAL/SUBJECTS AND METHODS: Women were recruited in four specialized centers for the management of osteoporosis in North, Center and South of Italy...
June 6, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28589060/seeding-of-a-pituitary-adenoma-or-atypical-pituitary-carcinoma
#19
Evan M Krueger, Jason Seibly
Pituitary carcinomas are defined as pituitary tumors with craniospinal and/or systemic metastasis. These are rare and highly aggressive lesions. We present an unusual case of a 52-year-old male who had a pituitary adenoma removed via craniotomy. The tumor recurred three years post-op near the surgical tract, and slowly enlarged before removal two years later. Technically, this lesion was defined as a pituitary carcinoma, even though the histology and clinical course were atypical. There is no standardized grading system for pituitary tumors and ideal criteria should correlate clinically...
May 2, 2017: Curēus
https://www.readbyqxmd.com/read/28588485/beneficial-effects-and-toxicity-studies-of-xian-ling-gu-bao-on-bone-metabolism-in-ovariectomized-rats
#20
Hao Wu, Qingxiang Zhong, Jing Wang, Man Wang, Fang Fang, Zhi Xia, Rongling Zhong, Houcai Huang, Zhongcheng Ke, Yingjie Wei, Liang Feng, Ziqi Shi, E Sun, Jie Song, Xiaobin Jia
Xian-ling-gu-bao (XLGB) is a well-known patented traditional Chinese prescription widely used to treat osteoporosis, osteoarthritis, aseptic bone necrosis, or climacteric syndrome. However, recent reports have suggested that XLGB may cause liver injury in humans. In the present study, we aimed to evaluate the efficacy of XLGB in the prevention of osteoporosis in the zebrafish and ovariectomized (OVX) rats, both of which have been used as osteoporosis models. The safety of XLGB after long-term administration to OVX rats was also assessed...
2017: Frontiers in Pharmacology
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