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https://www.readbyqxmd.com/read/28523456/bone-marrow-mesenchymal-stem-cell-administration-significantly-improves-outcome-after-retinal-ischemia-in-rats
#1
Biji Mathew, Jacqueline N Poston, John C Dreixler, Leianne Torres, Jasmine Lopez, Ruth Zelkha, Irina Balyasnikova, Maciej S Lesniak, Steven Roth
PURPOSE: Ischemia-associated retinal degeneration is one of the leading causes of vision loss, and to date, there are no effective treatment options. We hypothesized that delayed injection of bone-marrow stem cells (BMSCs) 24 h after the onset of ischemia could effectively rescue ischemic retina from its consequences, including apoptosis, inflammation, and increased vascular permeability, thereby preventing retinal cell loss. METHODS: Retinal ischemia was induced in adult Wistar rats by increasing intraocular pressure (IOP) to 130-135 mmHg for 55 min...
May 18, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28523165/plasma-levels-of-matrix-metalloproteinase-9-in-patients-undergoing-off-pump-coronary-artery-bypass-grafting
#2
Haiqing Li, Zhize Yuan, Sen Li, Quan Qi, Jun Liu, Mi Zhou, Junfeng Cai, Anqing Chen, Zhe Wang, Xiaofeng Ye, Qiang Zhao
BACKGROUND: Matrix metalloproteinase 9 (MMP9) has recently emerged as a risk predictor in patients with cardiovascular diseases. However, little is known about the significance of increased plasma MMP9 in patients with perioperative myocardial injury. We aimed to investigate the role of MMP9 in the occurrence of myocardial injury during off-pump coronary artery bypass grafting (OPCAB). METHODS: A total of 34 consecutive patients with coronary artery diseases (CAD) were recruited in this prospective, observational study...
April 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28516878/high-incidence-of-vertebral-osteoporotic-fracture-within-the-first-year-after-liver-transplantation
#3
Sarah Butin, Isabelle Griffoul, Fabien Espitalier, Ephrem Salamé, Denis Mulleman, Philippe Goupille
OBJECTIVES: Bone loss is a complication for patients with liver diseases and after transplantation, which results in increased fracture risk. The aim of this study was to determine the incidence of osteoporotic vertebral fractures following liver transplantation. METHODS: We performed a prospective study of patients who were awaiting liver transplantation. Patients were seen at baseline (visit 1) and one year after transplantation (visit 2). At each visit, risk factors of osteoporosis were collected, biochemical tests were performed and bone mineral density with Vertebral Fracture Assessment was assessed...
April 29, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28516234/assessing-long-term-return-to-play-after-hip-arthroscopy-in-football-players-evaluating-risk-factors-for-good-prognosis
#4
D Barastegui, R Seijas, P Alvarez-Diaz, E Rivera, E Alentorn-Geli, G Steinbacher, X Cuscó, R Cugat
PURPOSE: Groin pain is the third most common disease in football players and has often been associated with hip pathology such as femoroacetabular impingement and labral lesions. Hip arthroscopy offers possibilities of function restoration via minimally invasive procedures. The aim of this study is to evaluate professional football player's injuries and their return to play after hip arthroscopy for FAI and labral injuries. METHODS: Patients that underwent hip arthroscopy between 2009 and 2014 were selected retrospectively...
May 17, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28511465/digging-deeper-into-the-patello-femoral-joint-patello-femoral-composite-a-new-dimension-for-overstuffing-of-patello-femoral-joint
#5
Vikram Kishor Kandhari, Mohan M Desai, Surendar S Bava, Roshan N Wade
INTRODUCTION: Patello-femoral complications are the most common complications in postoperative Total Knee Arthroplasty (TKA) patients especially overstuffing of Patello - Femoral Joint (PFJ). So, to study the effects of overstuffing of PFJ in postoperative TKA patients we put forth a new dimension - "PATELLO - FEMORAL COMPOSITE (PFC)". This is the maximum distance between anterior cortical line of femur shaft and the anterior cortex of patella with knee in full extension. AIM: To calculate chances of overstuffing of PFJ in postoperative TKA patients and document the effect of overstuffing of PFJ on the passive knee Range of Motion (ROM) in post- op TKA patients...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28511433/clinico-radiologic-and-spirometric-profile-of-an-indian-population-with-post-tuberculous-obstructive-airway-disease
#6
Avradip Santra, Pravati Dutta, Rekha Manjhi, Sudarsan Pothal
INTRODUCTION: Tuberculosis is a public health problem in developing countries and in spite of receiving adequate anti-tuberculous therapy, patients often continues to have several post-tuberculous sequelae, especially airflow limitation. AIM: To evaluate pulmonary function by spirometry among post-tuberculosis cases with airway obstruction and their relationship with smoking. MATERIALS AND METHODS: All patients who presented to the pulmonary medicine Outpatient Department (OPD) with symptoms of obstructive airway disease and had completed adequate anti-tuberculous therapy for pulmonary tuberculosis were taken up for study...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28510081/qt-prolongation-as-an-isolated-long-term-cardiac-manifestation-of-dichlorvos-organophosphate-poisoning-in-rats
#7
Arthur Shiyovich, Ran Matot, Sigal Elyagon, Noah Liel-Cohen, Yossi Rosman, Shai Shrot, Michael Kassirer, Amos Katz, Yoram Etzion
Organophosphates (OP) are used extensively as pesticides and as chemical weapons. Cardiotoxicity is a major concern in survivors of the acute poisoning. To characterize the delayed cardiac effects of OP, rats were poisoned by intraperitoneal administration of dichlorvos. In group I, poisoning (0.25-, 0.75-, 1.4-LD50) was followed by application of atropine and obidoxime. In group II, poisoning (0.35-, 0.5-LD50) was done without antidotes. Cardiac evaluation included electrocardiography and echocardiography 2- and 6-week post-exposure, arrhythmia susceptibility following administration of Isoproterenol (150 mcg/kg), and histological evaluation...
May 16, 2017: Cardiovascular Toxicology
https://www.readbyqxmd.com/read/28509822/fracture-prevention-in-the-orthopaedic-environment-outcomes-of-a-coordinator-based-fracture-liaison-service
#8
Earl R Bogoch, Victoria Elliot-Gibson, Dorcas Beaton, Joanna Sale, Robert G Josse
BACKGROUND: Fracture liaison services focus on secondary fracture prevention by identifying patients at risk for future fracture and initiating appropriate evaluation, risk assessment, education, and therapeutic intervention. This study describes key clinical outcomes including bone mineral densitometry, physician assessment, and pharmacotherapy initiation in pharmacotherapy-naïve patients undergoing treatment for fragility fracture in a Canadian fracture liaison service. METHODS: We determined rates of post-fracture investigation and treatment for inpatients and outpatients with a fragility fracture seen in a coordinator-based fracture liaison service at an urban university trauma hospital...
May 17, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28507661/bone-marrow-aspirate-concentrate-in-combination-with-intravenous-iloprost-increases-bone-healing-in-patients-with-avascular-necrosis-of-the-femoral-head-a-matched-pair-analysis
#9
Hakan Pilge, Bernd Bittersohl, Johannes Schneppendahl, Tobias Hesper, Christoph Zilkens, Martin Ruppert, Rüdiger Krauspe, Marcus Jäger
With disease progression, avascular necrosis (AVN) of the femoral head may lead to a collapse of the articular surface. The exact pathophysiology of AVN remains unclear, although several conditions are known that can result in spontaneous cell death, leading to a reduction of trabecular bone and the development of AVN. Hip AVN treatment is stage-dependent in which two main stages of the disease can be distinguished: pre-collapse (ARCO 0-II) and post-collapse stage (ARCO III-IV, crescent sign). In the pre-collapse phase, core decompression (CD), with or without the addition of bone marrow (e...
November 17, 2016: Orthopedic Reviews
https://www.readbyqxmd.com/read/28502885/contra-lateral-bone-loss-at-the-distal-radius-in-postmenopausal-women-after-a-distal-radius-fracture-a-two-year-follow-up-hrpqct-study
#10
Joost J A de Jong, Jacobus J C Arts, Paul C Willems, Sandrine P G Bours, Judith P A Bons, Paul P C A Menheere, Bert van Rietbergen, Piet P Geusens, Joop P W van den Bergh
Opposite to the fracture side, bone mineral density (BMD) measured by DXA at the contra-lateral side does not change after a distal radius fracture. However, it is unknown if also bone micro-architecture and strength at the contralateral side are unaffected. Therefore, the aim of this study was to assess BMD, micro-architecture and bone mechanical properties at the contra-lateral side during two years follow-up after a distal radius fracture using high resolution peripheral quantitative computed tomography (HRpQCT)...
May 11, 2017: Bone
https://www.readbyqxmd.com/read/28500448/bone-loss-after-denosumab-only-partial-protection-with-zoledronate
#11
Ian R Reid, Anne M Horne, Borislav Mihov, Gregory D Gamble
A case series of six women with postmenopausal osteoporosis who had received continuous denosumab for 7 years and were then given a single infusion of zoledronate (5 mg) is reported. During denosumab treatment, bone mineral density (BMD) in the spine increased 18.5% (P = 0.006), and total hip BMD by 6.9% (P = 0.03). Post-zoledronate BMDs were measured 18-23 months after treatment, and there were significant declines at each site (P spine = 0.043, P hip = 0.005). Spine BMD remained significantly above the pre-denosumab baseline (+9...
May 13, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28499456/role-of-micrornas-in-premature-ovarian-insufficiency
#12
REVIEW
Ying Guo, Junyan Sun, Dongmei Lai
Premature ovarian insufficiency (POI) is a typical disorder of amenorrhea lasting for a minimum of 4 months. The typical characteristics comprised of declined estrogen and raised serum concentrations of follicle-stimulating hormone (FSH) in women <40-year-old, primarily originating from iatrogenic factors, karyotypic abnormalities, and genetic factors. However, the etiology of POI remains unknown in approximately 90% of cases. POI could lead to infertility, osteoporosis, cardiovascular disorder, and cognitive dysfunction...
May 12, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28497215/evidence-based-prevention-and-treatment-of-osteoporosis-after-spinal-cord-injury-a-systematic-review
#13
REVIEW
Saeed Soleyman-Jahi, Ali Yousefian, Radin Maheronnaghsh, Farhad Shokraneh, Shayan Abdollah Zadegan, Akbar Soltani, Seyed Mostafa Hosseini, Alexander R Vaccaro, Vafa Rahimi-Movaghar
PURPOSE: Spinal cord injury (SCI) results in accelerated bone mineral density (BMD) loss and disorganization of trabecular bone architecture. The mechanisms underlying post-SCI osteoporosis are complex and different from other types of osteoporosis. Findings of studies investigating efficacy of pharmacological or rehabilitative interventions in SCI-related osteoporosis are controversial. The aim of this study was to review the literature pertaining to prevention and evidence-based treatments of SCI-related osteoporosis...
May 11, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28496308/atorvastatin-a-double-weapon-in-osteoporosis-treatment-an-experimental-and-clinical-study
#14
Naglaa El-Nabarawi, Mohamed El-Wakd, Mostafa Salem
OBJECTIVE: The aim of this study was to evaluate the effect of atorvastatin on the bone formation and resorption markers in ovariectomized rats (experimental study), and to study its effect on the bone mineral density (BMD) in postmenopausal osteoporotic women (clinical study). MATERIALS AND METHODS: The study involved experimental and clinical aspects. In the experimental aspect, 42 female Wistar rats were divided into five groups: Group I (n=6; sham-operated), Group II (n=6; 1 mL of carboxymethyl cellulose [CMC] was administered orally), Group III (n=6; 20 mg/kg orally of atorvastatin was administered), Group IV (n=12; untreated ovariectomized [OVX] rats and served as a model of osteoporosis [OP]) and Group V (n=12; 20 mg/kg orally of atorvastatin was administered to ovariectomized rats)...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28489659/relationship-between-the-quantity-of-nerve-exposure-during-bilateral-sagittal-split-osteotomy-surgery-and-sensitive-recovery
#15
Paolo Gennaro, Maria Elisa Giovannoni, Niccolò Pini, Ikenna Valentine Aboh, Guido Gabriele, Giorgio Iannetti, Flavia Cascino
AIM AND OBJECTIVES: The purpose of this study was to evaluate how different exposures of the V3 nerves during orthognathic surgery impact neurosensory disturbances. METHODS: The study included 127 patients who underwent either bilateral sagittal split osteotomy (BSSO) or BSSO with maxillary le Fort 1. They were divided into 6 groups, identified by the quantity of V3 nerve exposure. All patients were examined in a pre-op period and again after 1, 3, 6 months post-op...
May 9, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28489626/general-health-status-after-non-operative-versus-operative-treatment-for-acute-complete-acromio-clavicular-joint-dislocation-results-of-a-multicenter-randomized-clinical-trial
#16
Jeffrey M Mah
OBJECTIVE: To assess the general health status of patients following non-operative (Non-op) versus operative (OP) treatment for acromioclavicular (AC) joint dislocations. DESIGN: Multicenter, randomized controlled clinical trial. SETTING: Eleven Canadian trauma centers. PARTICIPANTS: Eighty-three patients with acute (≤ 28 days old), complete (Rockwood grades III, IV, or V) dislocations of the AC joint. INTERVENTION: Participants were randomized to non-operative treatment or operative treatment with hook plate fixation...
May 5, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28489093/mgal-layered-double-hydroxide-chitosan-porous-scaffolds-loaded-with-pft%C3%AE-to-promote-bone-regeneration
#17
Yi-Xuan Chen, Rong Zhu, Qin-Fei Ke, You-Shui Gao, Chang-Qing Zhang, Ya-Ping Guo
Poor bone formation remains a key risk factor associated with acellular scaffolds that occurs in some bone defects, particularly in patients with metabolic bone disorders and local osteoporosis. We herein fabricated for the first time layered double hydroxide-chitosan porous scaffolds loaded with PFTα (LDH-CS-PFTα scaffolds) as therapeutic bone scaffolds for the controlled release of PFTα to enhance stem cell osteogenic differentiation and bone regeneration. The LDH-CS scaffolds had three-dimensional interconnected macropores, and plate-like LDH nanoparticles were uniformly dispersed within or on the CS films...
May 10, 2017: Nanoscale
https://www.readbyqxmd.com/read/28488465/surgical-management-of-lower-limb-fractures-in-patients-with-spinal-cord-injury-less-associated-with-complications-than-non-operative-management-a-retrospective-series-of-cases
#18
Alban Fouasson-Chailloux, Raphael Gross, Marc Dauty, Guillaume Gadbled, Sophie Touchais, Marc Le Fort, Brigitte Perrouin-Verbe
OBJECTIVES: To evaluate the difference in terms of overall complications between surgical and non-surgical management of lower limb fractures in patients with chronic spinal cord injury (SCI). DESIGN: A 13-year retrospective study including patients with chronic spinal cord lesion admitted for sublesional lower limb fractures. SETTING: University hospital SCI reference departments (Rehabilitation department and orthopedic department). PARTICIPANTS: Forty patients with SCI were included, 24 men and 16 women...
May 10, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28487619/one-step-minilaparotomy-assisted-transmesenteric-portal-vein-recanalization-combined-with-transjugular-intrahepatic-portosystemic-shunt-placement-a-novel-surgical-proposal-in-pediatrics
#19
Gloria Pelizzo, Pietro Quaretti, Lorenzo Paolo Moramarco, Riccardo Corti, Marcello Maestri, Giulio Iacob, Valeria Calcaterra
Transjugular intrahepatic portosystemic shunt (TIPS) placement is a standard procedure for the treatment of portal hypertension complications. When this conventional approach is not feasible, alternative procedures for systemic diversion of portal blood have been proposed. A one-step interventional approach, combining minilaparotomy-assisted transmesenteric (MAT) antegrade portal recanalization and TIPS, is described in an adolescent with recurrent esophageal varice bleeding and portal cavernoma (PC). A 16-year-old girl was admitted to our Unit because of repeated bleeding episodes over a short period of time due to esophageal varices in the context of a PC...
April 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28482507/a-review-of-tio2-nts-on-ti-metal-electrochemical-synthesis-functionalization-and-potential-use-as-bone-implants
#20
REVIEW
Nasser K Awad, Sharon L Edwards, Yosry S Morsi
Degenerative diseases of bone such as osteoarthritis and osteoporosis can lead to bone fractures and immobility, compromising quality of life. Titanium (Ti)-based implants have been intensively investigated for bone repair, with these implants, demonstrating improved outcomes compared to stainless steel and cobalt-chrome alloys, owing to superior mechanical properties and biocompatibility. However, osseointegration between the Ti-based implants and the surrounding bone tissue needs to be improved. Surface modification of Ti-based implants provides a solution for addressing this, with electrochemical anodization becoming a realistic approach for the fabrication of hierarchical structured for example nanotubes (NTs), implant surfaces...
July 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
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