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https://www.readbyqxmd.com/read/28340217/establishment-of-reference-interval-for-alkaline-phosphatase-in-healthy-children-of-various-ethnicities-aged-0-12-years
#1
Gu Wanjian, Hu Jie, Ge Liang, Wang Cheng, Xu Tian, Shen Jianjiang, Zhang Chunni
Background: To establish a reference interval of alkaline phosphatase for healthy children of various ethnicities, aged 0 years to 12 years in China. Methods: According to the Clinical and Laboratory Standards Institute guideline C28-A3, blood specimens were collected in the morning after overnight fasting from 502 healthy children to determine the alkaline phosphatase (ALP) level, using the Beckman AU5800 automatic biochemical analyzer. Children were grouped by sex and age...
March 18, 2017: Laboratory Medicine
https://www.readbyqxmd.com/read/28339793/lameness-assessment-with-automatic-monitoring-of-activity-in-commercial-broiler-flocks
#2
A M Silvera, T G Knowles, A Butterworth, D Berckmans, E Vranken, H J Blokhuis
The possibility of using automatic recordings of broiler chicken activity in commercial flocks to assess the birds΄ walking ability (lameness) was investigated. Data were collected from 5 commercial broiler farms in 4 European countries, using 16 flocks and 33 assessment occasions. Lameness was assessed using established gait scoring methods (Kestin et al., 1992; Welfare Quality®, 2009) and took place at 3, 4, and 5 wk of age. Gait score (GS) was used to assess the birds' walking ability, and automatic recordings of bird activity were collected using the eYeNamic™ camera system before, during, and after an assessor walked through the house...
February 23, 2017: Poultry Science
https://www.readbyqxmd.com/read/28339656/development-of-a-real-time-wave-field-reconstruction-tem-system-i-incorporation-of-an-auto-focus-tracking-system
#3
Takahiro Tamura, Yoshihide Kimura, Yoshizo Takai
We have developed a real-time wave field reconstruction transmission electron microscope system that enables auto focus tracking at a video rate. In the developed system, a high-speed image calculation technique using a graphical processing unit was incorporated along with two techniques facilitating high-speed focus control using high-voltage modulation and weighted image integration using exposure time control. By utilizing these techniques, the sample drift induced in the Z-axis direction can be measured and automatically corrected for every 1/30 of a second...
February 18, 2017: Microscopy
https://www.readbyqxmd.com/read/28339578/safe-automatic-one-lead-electrocardiogram-analysis-in-screening-for-atrial-fibrillation
#4
Emma Svennberg, Martin Stridh, Johan Engdahl, Faris Al-Khalili, Leif Friberg, Viveka Frykman, Mårten Rosenqvist
Aims: Screening for atrial fibrillation (AF) using intermittent electrocardiogram (ECG) recordings can identify individuals at risk of AF-related morbidity in particular stroke. We aimed to validate the performance of an AF screening algorithm compared with manual ECG analysis by specially trained nurses and physicians (gold standard) in 30 s intermittent one-lead ECG recordings. Methods: The STROKESTOP study is a mass-screening study for AF using intermittent ECG recordings...
October 6, 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28339176/identification-of-likely-associations-between-cerebral-folate-deficiency-and-complex-genetic-and-metabolic-pathogenesis-of-autism-spectrum-disorders-by-utilization-of-a-pilot-interaction-modeling-approach
#5
Daniel Krsička, Jan Geryk, Markéta Vlčková, Markéta Havlovicová, Milan Macek, Radka Pourová
Recently, cerebral folate deficiency (CFD) was suggested to be involved in the pathogenesis of autism spectrum disorders (ASD). However, the exact role of folate metabolism in the pathogenesis of ASD, identification of underlying pathogenic mechanisms and impaired metabolic pathways remain unexplained. The aim of our study was to develop and test a novel, unbiased, bioinformatics approach in order to identify links between ASD and disturbed cerebral metabolism by focusing on abnormal folate metabolism, which could foster patient stratification and novel therapeutic interventions...
March 24, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/28339108/very-high-energy-electron-vhee-beams-in-radiation-therapy-treatment-plan-comparison-between-vhee-vmat-and-ppbs
#6
Emil Schüler, Kjell Eriksson, Elin Hynning, Steven L Hancock, Susan M Hiniker, Magdalena Bazalova-Carter, Tony Wong, Quynh-Thu Le, Billy W Loo, Peter G Maxim
PURPOSE: The aim of this study was to evaluate the performance of very high energy electron beams (VHEE) beams in comparison to clinically derived treatment plans generated with volumetric modulated arc therapy (VMAT) and proton pencil beam scanning (PPBS) technology. We developed a custom optimization script that could be applied automatically across modalities to eliminate operator bias during IMRT optimization. METHODS: Four clinical cases were selected (prostate cancer, lung cancer, pediatric brain tumor, and head and neck cancer (HNC))...
March 24, 2017: Medical Physics
https://www.readbyqxmd.com/read/28339103/iterative-dataset-optimization-in-automated-planning-implementation-for-breast-and-rectal-cancer-radiotherapy
#7
Jiawei Fan, Jiazhou Wang, Zhen Zhang, Weigang Hu
PURPOSE: To develop a new automated treatment planning solution for breast and rectal cancer radiotherapy. METHODS: The automated treatment planning solution developed in this study includes selection of the iterative optimized training dataset, dose volume histogram (DVH) prediction for the organs at risk (OARs), and automatic generation of clinically acceptable treatment plans. The iterative optimized training dataset is selected by an iterative optimization from 40 treatment plans for left-breast and rectal cancer patients who received radiation therapy...
March 24, 2017: Medical Physics
https://www.readbyqxmd.com/read/28338934/alternative-figures-of-merit-in-digital-mammography
#8
M Borg, A Konstantinidis
The aim of this study is to explore the use of a quality (Q) factor in digital mammography as a figure-of-merit. Q factors take a reference value into account and can be compared to a theoretical value. They are also intended to summarise the performance of any unit based on a number. The mean glandular dose (MGD)-normalised Q factors were also introduced based on the relationship of the Q factors with MGD. Interestingly, the automatic exposure control exposures did not render the maximum normalised Q factor values as expected, which could indicate the need for further optimisation...
March 14, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/28338829/seeing-is-not-stereotyping-the-functional-independence-of-categorization-and-stereotype-activation
#9
Tiffany A Ito, Silvia Tomelleri
Social categorization has been viewed as necessarily resulting in stereotyping, yet extant research suggests the two processes are differentially sensitive to task manipulations. Here we simultaneously test the degree to which race perception and stereotyping are conditionally automatic. Participants performed a sequential priming task while either explicitly attending to the race of face primes or directing attention away from their semantic nature. We find a dissociation between the perceptual encoding of race and subsequent activation of associated stereotypes, with race perception occurring in both task conditions, but implicit stereotyping occurring only when attention is directed to the race of the face primes...
February 23, 2017: Social Cognitive and Affective Neuroscience
https://www.readbyqxmd.com/read/28338742/brain-mechanisms-for-loss-of-awareness-of-thought-and-movement
#10
Eamonn Walsh, David A Oakley, Peter W Halligan, Mitul A Mehta, Quinton Deeley
Loss or reduction of awareness is common in neuropsychiatric disorders and culturally influenced dissociative phenomena but the underlying brain mechanisms are poorly understood. fMRI was combined with suggestions for automatic writing in 18 healthy highly hypnotically suggestible individuals in a within-subjects design to determine whether clinical alterations in awareness of thought and movement can be experimentally modelled and studied independently of illness. Subjective ratings of control, ownership, and awareness of thought and movement, and fMRI data were collected following suggestions for thought insertion and alien control of writing movement, with and without loss of awareness...
February 17, 2017: Social Cognitive and Affective Neuroscience
https://www.readbyqxmd.com/read/28337763/automatic-washing-of-thawed-haematopoietic-progenitor-cell-grafts-a-preclinical-evaluation
#11
M Abonnenc, B Pesse, J-D Tissot, S Barelli, N Lion
BACKGROUND AND OBJECTIVES: Autologous haematopoietic progenitor cell (HPC) is a prerequisite for high-dose chemotherapy in treatment of several haematologic and non-haematologic malignancies. HPCs are collected by apheresis and cryopreserved until infusion. Postinfusion adverse events have been in part related to the dimethyl sulphoxide (DMSO) used as cryoprotectant. The aim was to evaluate (i) an automated sequential washing procedure for DMSO removal in thawed HPC grafts and (ii) washing solutions in replacement of hydroxyethyl starch (HES)-based solutions...
March 23, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28337429/investigating-cardiac-motion-patterns-using-synthetic-high-resolution-3d-cardiovascular-magnetic-resonance-images-and-statistical-shape-analysis
#12
Benedetta Biffi, Jan L Bruse, Maria A Zuluaga, Hopewell N Ntsinjana, Andrew M Taylor, Silvia Schievano
Diagnosis of ventricular dysfunction in congenital heart disease is more and more based on medical imaging, which allows investigation of abnormal cardiac morphology and correlated abnormal function. Although analysis of 2D images represents the clinical standard, novel tools performing automatic processing of 3D images are becoming available, providing more detailed and comprehensive information than simple 2D morphometry. Among these, statistical shape analysis (SSA) allows a consistent and quantitative description of a population of complex shapes, as a way to detect novel biomarkers, ultimately improving diagnosis and pathology understanding...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28337411/physiological-and-pathological-high-frequency-oscillations-have-distinct-sleep-homeostatic-properties
#13
Nicolás von Ellenrieder, François Dubeau, Jean Gotman, Birgit Frauscher
OBJECTIVE: The stage of sleep is a known modulator of high-frequency oscillations (HFOs). For instance, high amplitude slow waves during NREM sleep and the subtypes of REM sleep were shown to contribute to a better separation between physiological and pathological HFOs. This study investigated rates and spatial spread of the different HFO types (physiological and pathological ripples in the 80-250 Hz frequency band, and fast ripples above 250 Hz) depending on time spent in sleep across the different sleep cycles...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28337400/prototype-of-an-interface-for-hyphenating-distillation-with-gas-chromatography-and-mass-spectrometry
#14
Ya-Ru Tang, Hui-Hsien Yang, Pawel L Urban
Chemical analysis of complex matrices-containing hundreds of compounds-is challenging. Two-dimensional separation techniques provide an efficient way to reduce complexity of mixtures analyzed by mass spectrometry (MS). For example, gasoline is a mixture of numerous compounds, which can be fractionated by distillation techniques. However, coupling conventional distillation with other separations as well as MS is not straightforward. We have established an automatic system for online coupling of simple microscale distillation with gas chromatography (GC) and electron ionization MS...
2017: Mass Spectrometry
https://www.readbyqxmd.com/read/28337135/deficits-in-letter-speech-sound-associations-but-intact-visual-conflict-processing-in-dyslexia-results-from-a-novel-erp-paradigm
#15
Sarolta Bakos, Karin Landerl, Jürgen Bartling, Gerd Schulte-Körne, Kristina Moll
The reading and spelling deficits characteristic of developmental dyslexia (dyslexia) have been related to problems in phonological processing and in learning associations between letters and speech-sounds. Even when children with dyslexia have learned the letters and their corresponding speech sounds, letter-speech sound associations might still be less automatized compared to children with age-adequate literacy skills. In order to examine automaticity in letter-speech sound associations and to overcome some of the disadvantages associated with the frequently used visual-auditory oddball paradigm, we developed a novel electrophysiological letter-speech sound interference paradigm...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28336674/interchangeability-and-reliability-of-macular-perfusion-parameter-measurements-using-optical-coherence-tomography-angiography
#16
Jing Dong, Ya-Ding Jia, Qiang Wu, Suhua Zhang, Yali Jia, David Huang, Xiaogang Wang
AIM: The aim of the study was to investigate the interchangeability and reliability of macular perfusion measurements using optical coherence tomography angiography. METHODS: A prospective cross-sectional observational study. Healthy adult Chinese subjects were recruited. Macular perfusion parameters were automatically analysed by software included in a spectral-domain optical coherence tomography system. The vessel density (VD) of the whole, parafovea, superior-hemi, inferior-hemi, fovea, temporal, superior, nasal and inferior quadrants as well as the foveal avascular zone (FAZ) and choroidal capillary VD (CCVD) were quantified...
March 23, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28336503/tweet-for-behavior-change-using-social-media-for-the-dissemination-of-public-health-messages
#17
Aisling Gough, Ruth F Hunter, Oluwaseun Ajao, Anna Jurek, Gary McKeown, Jun Hong, Eimear Barrett, Marbeth Ferguson, Gerry McElwee, Miriam McCarthy, Frank Kee
BACKGROUND: Social media public health campaigns have the advantage of tailored messaging at low cost and large reach, but little is known about what would determine their feasibility as tools for inducing attitude and behavior change. OBJECTIVE: The aim of this study was to test the feasibility of designing, implementing, and evaluating a social media-enabled intervention for skin cancer prevention. METHODS: A quasi-experimental feasibility study used social media (Twitter) to disseminate different message "frames" related to care in the sun and cancer prevention...
March 23, 2017: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/28336480/can-a-commercially-available-epid-dosimetry-system-detect-small-daily-patient-setup-errors-for-cranial-imrt-srs
#18
Emmelyn S Hsieh, Katherine S Hansen, Michael S Kent, Sanjeev Saini, Sonja Dieterich
PURPOSE: The purpose of this study was to determine if the Sun Nuclear PerFRACTION electronic portal imager device dosimetry software would be able to detect setup errors in a clinical setting and would be able to correctly identify the direction in which the setup error was introduced. METHODS AND MATERIALS: A 7-field intensity modulated radiation therapy (IMRT) treatment plan for a centrally located tumor was developed for 1 phantom and 5 canine cadaver heads...
December 24, 2016: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28336396/tumor-control-index-as-a-new-tool-to-assess-tumor-growth-in-experimental-animals
#19
William L Corwin, Hakimeh Ebrahimi-Nik, Stephanie M Floyd, Pouya Tavousi, Ion I Mandoiu, Pramod K Srivastava
Measurement of tumor diameters, tumor volumes, or area under the curve has been traditionally used to quantitate and compare tumor growth curves in immune competent as well as immune-compromised mice and rats. Here, using tumor growth data from a large number of mice challenged with live tumor cells, we describe the use of a new composite parameter, Tumor Control Index (TCI) as an alternative method to do the same. This index, comprised of three distinct values, the Tumor Progression Score, Tumor Rejection Score, and Tumor Stability Score, provides a complete picture of nearly every aspect of tumor growth in large numbers of animals, can be deduced automatically from tumor diameter or volume data, and can be used to compare several groups of animals in different experiments...
March 20, 2017: Journal of Immunological Methods
https://www.readbyqxmd.com/read/28336360/gain-a-graph-based-method-to-automatically-analyze-neurite-outgrowth-in-cell-cultures
#20
B L Long, H Li, A Mahadevan, T Tang, K Balotin, N Grandel, J Soto, S Y Wong, A Abrego, S Li, A A Qutub
BACKGROUND: Neurite outgrowth is a metric widely used to assess the success of in vitro neural stem cell differentiation or neuron reprogramming protocols and of high-content screening assays for neural regenerative drug discovery. However, neurite measurements are tedious to perform manually, and there is a paucity of freely available, fully automated software to determine neurite measurements and neuron counting. To provide such a tool to the neurobiology, stem cell, cell engineering, and neuroregenerative communities, we developed an algorithm for performing high-throughput neurite analysis in immunofluorescence images...
March 20, 2017: Journal of Neuroscience Methods
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