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https://www.readbyqxmd.com/read/27923037/adherence-to-colorectal-cancer-screening-four-rounds-of-faecal-immunochemical-test-based-screening
#1
Manon van der Vlugt, Esmée J Grobbee, Patrick Mm Bossuyt, Evelien Bongers, Wolfert Spijker, Ernst J Kuipers, Iris Lansdorp-Vogelaar, Marie-Louise Essink-Bot, Manon C W Spaander, Evelien Dekker
BACKGROUND: The effectiveness of faecal immunochemical test (FIT)-based screening programs is highly dependent on consistent participation over multiple rounds. We evaluated adherence to FIT screening over four rounds and aimed to identify determinants of participation behaviour. METHODS: A total of 23 339 randomly selected asymptomatic persons aged 50-74 years were invited for biennial FIT-based colorectal cancer screening between 2006 and 2014. All were invited for every consecutive round, except for those who had moved out of the area, passed the upper age limit, or had tested positive in a previous screening round...
December 6, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27922854/identification-of-hiv-infection-related-dna-methylation-sites-and-advanced-epigenetic-aging-in-hiv-treatment-na%C3%A3-ve-u-s-veterans
#2
Kristin N Nelson, Qin Hui, David Rimland, Ke Xu, Matthew S Freiberg, Amy C Justice, Vincent C Marconi, Yan V Sun
OBJECTIVE: HIV-positive individuals are at higher risk than healthy persons for aging-related diseases, including myocardial infarction and non-AIDS defining cancers. Recent evidence suggests that HIV infection may modulate changes in the host cell epigenome, and these changes represent a potential mechanism through which HIV infection accelerates aging. We assessed the difference in DNAm age, an aging marker involving multiple age-related CpG sites, among antiretroviral treatment (ART) naïve HIV-positive and HIV-negative individuals in a cohort of veterans from the Veterans Aging Cohort Study (VACS)...
December 5, 2016: AIDS
https://www.readbyqxmd.com/read/27922795/breast-cancer-risk-reduction-decisions-of-the-brca-positive-patient-an-observational-study-at-a-single-institution
#3
Dana Johns, Jay Agarwal, Layla Anderson, Jian Ying, Wendy Kohlmann
BACKGROUND: BRCA1 and BRCA2 gene mutations carry with them a 50%-80% risk of developing breast cancer. The best choice for managing breast cancer risk in patients with a BRCA1/2 mutation is a highly personal decision. Options for risk management include surveillance with multiple modalities or prophylactic surgical intervention. The goal of this study was to gain a better understanding of contributing factors affecting the decision for managing breast cancer risk made by patients who are BRCA mutation positive and cancer free...
December 6, 2016: Journal of Women's Health
https://www.readbyqxmd.com/read/27922142/prevalence-and-risk-factors-of-caregiver-dependence-among-older-adults-in-a-southeast-asian-population
#4
Louisa Picco, Edimansyah Abdin, Janhavi A Vaingankar, Shirlene Pang, Saleha Shafie, Rajeswari Sambasivam, Siow Ann Chong, Mythily Subramaniam
INTRODUCTION: Currently very little is known about the prevalence or magnitude of caregiver dependence in Singapore and thus, there is a need to fill this gap in this multiethnic ageing population. This study aims to determine the prevalence and risk factors of caregiver dependence among older adults in Singapore. MATERIALS AND METHODS: Data were used from the Well-being of the Singapore Elderly (WiSE) study, a nationally representative, cross-sectional survey among Singapore residents aged 60 years and above...
November 2016: Annals of the Academy of Medicine, Singapore
https://www.readbyqxmd.com/read/27921992/the-hubble-trial-haemorrhoidal-artery-ligation-hal-versus-rubber-band-ligation-rbl-for-symptomatic-second-and-third-degree-haemorrhoids-a-multicentre-randomised-controlled-trial-and-health-economic-evaluation
#5
Steven Brown, Jim Tiernan, Katie Biggs, Daniel Hind, Neil Shephard, Mike Bradburn, Allan Wailoo, Abualbishr Alshreef, Lizzie Swaby, Angus Watson, Simon Radley, Oliver Jones, Paul Skaife, Anil Agarwal, Pasquale Giordano, Marc Lamah, Mark Cartmell, Justin Davies, Omar Faiz, Karen Nugent, Andrew Clarke, Angus MacDonald, Phillip Conaghan, Paul Ziprin, Rohit Makhija
BACKGROUND: Optimal surgical intervention for low-grade haemorrhoids is unknown. Rubber band ligation (RBL) is probably the most common intervention. Haemorrhoidal artery ligation (HAL) is a novel alternative that may be more efficacious. OBJECTIVE: The comparison of HAL with RBL for the treatment of grade II/III haemorrhoids. DESIGN: A multicentre, parallel-group randomised controlled trial. PERSPECTIVE: UK NHS and Personal Social Services...
November 2016: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/27921197/counselees-perspectives-of-genomic-counseling-following-online-receipt-of-multiple-actionable-complex-disease-and-pharmacogenomic-results-a-qualitative-research-study
#6
Kevin Sweet, Shelly Hovick, Amy C Sturm, Tara Schmidlen, Erynn Gordon, Barbara Bernhardt, Lisa Wawak, Karen Wernke, Joseph McElroy, Laura Scheinfeldt, Amanda E Toland, J S Roberts, Michael Christman
Genomic applications raise multiple challenges including the optimization of genomic counseling (GC) services as part of the results delivery process. More information on patients' motivations, preferences, and informational needs are essential to guide the development of new, more efficient practice delivery models that capitalize on the existing strengths of a limited genetic counseling workforce. Semi-structured telephone interviews were conducted with a subset of counselees from the Coriell Personalized Medicine Collaborative following online receipt of multiple personalized genomic test reports...
December 5, 2016: Journal of Genetic Counseling
https://www.readbyqxmd.com/read/27920581/hiv-stigma-and-associated-factors-among-antiretroviral-treatment-clients-in-jimma-town-southwest-ethiopia
#7
Neno Nikus Fido, Mamusha Aman, Zewdie Brihnu
BACKGROUND: HIV stigma has an important role in the spread of the AIDS epidemic. It profoundly affects the lives of individuals living with HIV/AIDS. Fear of being identified as having HIV may discourage a person from getting tested, accessing medical services, and obtaining medications. Thus, this study was aimed at assessing HIV-related stigma and associated factors among antiretroviral treatment (ART) clients in Jimma town, Oromia region, Southwest Ethiopia. METHODS: A facility-based cross-sectional study was conducted from March 11 to April 26, 2015, in ART clinics in Jimma town...
2016: HIV/AIDS: Research and Palliative Care
https://www.readbyqxmd.com/read/27920346/how-transformational-leadership-influences-work-engagement-among-nurses-does-person-job-fit-matter
#8
Ibeawuchi K Enwereuzor, Leonard I Ugwu, Onyinyechi A Eze
The current study examines whether person-job fit moderates the relationship between transformational leadership and work engagement. Data were collected using cross-sectional design from 224 (15 male and 209 female) hospital nurses. Participants completed measures of transformational leadership, person-job fit, and work engagement. Moderated multiple regression results showed that transformational leadership had a significant positive predictive relationship with work engagement, and person-job fit had a significant positive predictive relationship with work engagement...
December 5, 2016: Western Journal of Nursing Research
https://www.readbyqxmd.com/read/27919507/predictors-of-long-term-interferon-discontinuation-in-newly-diagnosed-relapsing-multiple-sclerosis
#9
Marcello Moccia, Raffaele Palladino, Antonio Carotenuto, Cinzia Valeria Russo, Maria Triassi, Roberta Lanzillo, Vincenzo Brescia Morra
BACKGROUND: Interferon-β has long-term safety and efficacy profiles for Relapsing Remitting Multiple Sclerosis (RRMS). However, the increasing number of available treatments requires to improve patient profiling and to perform individualized clinical decisions. Therefore, the present study investigated predictors of Interferon-β discontinuation. METHODS: The present retrospective observational cohort study included 499 newly diagnosed, drug naïve RRMS subjects receiving Interferon-β as first disease modifying treatment (DMT), during a 7...
November 2016: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/27919502/motor-fatigability-after-low-intensity-hand-grip-exercises-in-persons-with-multiple-sclerosis
#10
Deborah Severijns, Mieke Lemmens, Ronald Thoelen, Peter Feys
INTRODUCTION: During maximal, sustained contractions, persons with multiple sclerosis (PwMS) show higher motor fatigability in comparison with healthy persons. It is not known if motor fatigability is also different between PwMS and healthy persons during low-intensity exercises. Thus, the aim of this study was to determine the difference in hand grip fatigability between healthy persons and PwMS for both hands during low-intensity hand grip exercises. METHODS: 19 PwMS and 19 healthy controls performed 18min of hand grip exercises at a maximum of 25% of the maximal voluntary strength, with an electronic hand dynamometer...
November 2016: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/27919487/inverse-comorbidity-in-multiple-sclerosis-findings-in-a-complete-nationwide-cohort
#11
Anja Thormann, Nils Koch-Henriksen, Bjarne Laursen, Per Soelberg Sørensen, Melinda Magyari
BACKGROUND: Inverse comorbidity is disease occurring at lower rates than expected among persons with a given index disease. The objective was to identify inverse comorbidity in MS. METHODS: We performed a combined case-control and cohort study in a total nationwide cohort of cases with clinical onset of MS 1980-2005. We randomly matched each MS-case with five population controls. Comorbidity data were obtained from multiple, independent nationwide registries. Cases and controls were followed from January 1977 to the index date, and from the index date through December 2012...
November 2016: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/27919481/effect-of-slow-release-fampridine-on-muscle-strength-rate-of-force-development-functional-capacity-and-cognitive-function-in-an-enriched-population-of-ms-patients-a-randomized-double-blind-placebo-controlled-study
#12
H B Jensen, J L Nielsen, M Ravnborg, U Dalgas, P Aagaard, E Stenager
DESIGN: This study was conducted as a randomized, double blind, placebo-controlled parallel group trial preceded by open label enrichment phase. OBJECTIVES: The objectives of this study were 1) to examine the effect of SR-Fampridine treatment on muscle strength in terms of maximal voluntary contraction (MVC) and rate of force development (RFD) of the lower extremities and 2) to replicate previously published data on the effect of slow release-Fampridine (SR-Fampridine) on the functional capacity of the lower limbs, the upper limb and cognitive function, in persons with multiple sclerosis (pwMS)...
November 2016: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/27919479/how-to-refer-to-people-with-disease-in-research-outputs-the-disconnection-between-academic-practise-and-that-preferred-by-people-with-multiple-sclerosis
#13
David Baker, Ananthi Anandhakrishnan, Katie A Tuite-Dalton, Hazel Lockart-Jones, Rodden M Middleton, David V Ford, Christina Crowe, Gavin Giovannoni
BACKGROUND: Increasingly, Government and Charity funders require public engagement in research. Invariably these research outputs describe the condition of someone with the disease of interest. We therefore sought to identify the preferred descriptor of someone with a disease, such as multiple sclerosis (MS) and to determine what descriptors are currently used by academics. METHODS: Several surveys were undertaken: one from the Research Network of the MS Society (MSSRN), a major MS Charity within the United Kingdom, who are involved in reviewing grant applications, priority setting and research governance (n=146), and surveys from both the United Kingdom MS register (MSR; n=1713) and the North American Research Committee on Multiple Sclerosis (NARCOMS) registry (n=518)...
November 2016: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/27919303/mental-illness-stigma-and-suicidality-the-role-of-public-and-individual-stigma
#14
N Oexle, T Waldmann, T Staiger, Z Xu, N Rüsch
AIMS: Suicide rates are increased among unemployed individuals and mental illness stigma can contribute to both unemployment and suicidality. Persons with mental illness perceive negative attitudes among the general public and experience discrimination in their everyday life (=public stigma components) potentially leading to self-stigma and anticipated discrimination (=individual stigma components). Previous research found evidence for an association between aspects of mental illness stigma and suicidality, but has not yet clarified the underlying pathways explaining how different stigma components interact and contribute to suicidal ideation...
December 6, 2016: Epidemiology and Psychiatric Sciences
https://www.readbyqxmd.com/read/27919145/-development-of-a-predictive-model-of-death-or-urgent-hospitalization-to-identify-frail-elderly
#15
Paolo Pandolfi, Natalina Collina, Paolo Marzaroli, Elisa Stivanello, Muriel Assunta Musti, Chiara Giansante, Vincenza Perlangeli, Lorenzo Pizzi, Sara De Lisio, Fausto Francia
OBJECTIVES: to develop and validate a predictive model of mortality or emergency hospitalization in all subjects aged 65 years and over. DESIGN: cohort study based on 9 different databases linked with each other. SETTING AND PARTICIPANTS: the model was developed on the population aged 65 years and over resident at 01.01.2011 for at least two years in the city of Bologna (Emilia-Romagna Region, Northern Italy); 96,000 persons were included...
November 2016: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/27919063/predictors-of-low-back-pain-in-nursing-home-workers-after-implementation-of-a-safe-resident-handling-programme
#16
Judith E Gold, Laura Punnett, Rebecca J Gore
OBJECTIVES: Healthcare workers have high rates of low back pain (LBP) related to handling patients. A large chain of nursing homes experienced reduced biomechanical load, compensation claims and costs following implementation of a safe resident handling programme (SRHP). The aim of this study was to examine whether LBP similarly declined and whether it was associated with relevant self-reported occupational exposures or personal health factors. METHODS: Worker surveys were conducted on multiple occasions beginning with the week of first SRHP introduction (baseline)...
November 10, 2016: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/27918703/patterns-and-predictors-of-change-in-moderate-to-vigorous-physical-activity-over-time-in-multiple-sclerosis
#17
Rachel E Klaren, Jeffer E Sasaki, Edward McAuley, Robert W Motl
BACKGROUND: Physical inactivity is common in persons with multiple sclerosis (MS), but there is very little known about the pattern and predictors of changes in physical activity over time. PURPOSE: This study examined changes in moderate-to-vigorous physical activity (MVPA) over a 30-month time period and the demographic and clinical predictors of such changes in relapsing-remitting MS (RRMS). METHODS: 269 persons with MS wore an accelerometer for a 7-day period and completed a demographic/clinical scale every 6 months over a 30-month period...
December 5, 2016: Journal of Physical Activity & Health
https://www.readbyqxmd.com/read/27918663/comparison-of-critical-power-and-w-derived-from-two-or-three-maximal-tests
#18
Len Parker Simpson, Mehdi Kordi
PURPOSE: Typically, accessing the asymptote (Critical Power; CP) and curvature constant (W') parameters of the hyperbolic power-duration relationship requires multiple constant-power, exhaustive exercise trials, spread over several visits. However, more recently single-visit protocols and personal power meters have been used. We investigated the practicality of using a two-trial, single-visit protocol in providing reliable CP & W' estimates. METHODS: 8 trained cyclists underwent 3- and 12-min maximal exercise trials in a single session to derive (2-trial) CP & W' estimates...
December 5, 2016: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/27918589/outcomes-of-cataract-surgery-in-urban-and-rural-population-in-the-south-indian-state-of-andhra-pradesh-rapid-assessment-of-visual-impairment-ravi-project
#19
Srinivas Marmamula, Rohit C Khanna, Konegari Shekhar, Gullapalli N Rao
OBJECTIVE: To assess the visual outcomes after cataract surgery among urban and rural population aged ≥40 years in the South India state of Andhra Pradesh. METHODS: A population based cross-sectional study was conducted in which 7800 subjects were sampled from two rural and one urban location. Visual Acuity was assessed and eye examination were performed by trained personnel. A questionnaire was used to collect personal and demographic information, and history of cataract surgery...
2016: PloS One
https://www.readbyqxmd.com/read/27918570/hiv-pre-exposure-prophylaxis-is-it-just-about-pills
#20
Jose V Fernandez-Montero
The increasing use of antiretrovirals for averting HIV infection before potential exposure is under debate. Whereas there is no doubt about the benefit of using Truvada® (tenofovir plus emtricitabine) to reduce HIV acquisition in uninfected persons who have sex with HIV-infected stable partners, concerns are rising about the increasing rate of sexually transmitted infections in subjects engaged in sex with multiple partners, due to misinterpreted self-security.
October 2016: AIDS Reviews
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