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https://www.readbyqxmd.com/read/28445812/portable-aptamer-biosensor-of-platelet-derived-growth-factor-bb-using-a-personal-glucose-meter-with-triply-amplified
#1
Lu Hong, Fu Zhou, Dongmin Shi, Xiaojun Zhang, Guangfeng Wang
Sensitive and rapid detection of platelet-derived growth factor BB (PDGF-BB), a cancer-related protein, could help early diagnosis, treatment, and prognosis of cancers. Although some methods have been developed to detect PDGF-BB, few can provide quantitative results using an affordable and portable device that is suitable for home use or field application. In this work, we report the first use of a portable kind of personal glucose meter (PGM) combining a catalytic and molecular beacon (CAMB) system with a cation exchange reaction (CX reaction) for ultrasensitive PDGF-BB assay...
April 19, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28444290/low-density-lipoproteins-cause-atherosclerotic-cardiovascular-disease-1-evidence-from-genetic-epidemiologic-and-clinical-studies-a-consensus-statement-from-the-european-atherosclerosis-society-consensus-panel
#2
Brian A Ference, Henry N Ginsberg, Ian Graham, Kausik K Ray, Chris J Packard, Eric Bruckert, Robert A Hegele, Ronald M Krauss, Frederick J Raal, Heribert Schunkert, Gerald F Watts, Jan Borén, Sergio Fazio, Jay D Horton, Luis Masana, Stephen J Nicholls, Børge G Nordestgaard, Bart van de Sluis, Marja-Riitta Taskinen, Lale Tokgözoglu, Ulf Landmesser, Ulrich Laufs, Olov Wiklund, Jane K Stock, M John Chapman, Alberico L Catapano
Aims: To appraise the clinical and genetic evidence that low-density lipoproteins (LDLs) cause atherosclerotic cardiovascular disease (ASCVD). Methods and results: We assessed whether the association between LDL and ASCVD fulfils the criteria for causality by evaluating the totality of evidence from genetic studies, prospective epidemiologic cohort studies, Mendelian randomization studies, and randomized trials of LDL-lowering therapies. In clinical studies, plasma LDL burden is usually estimated by determination of plasma LDL cholesterol level (LDL-C)...
April 24, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28443805/-a-population-targeted-approach-to-connect-prevention-care-and-welfare-visualising-the-trend
#3
L C Lemmens, H W Drewes, M Lette, C A Baan
OBJECTIVE: To map initiatives in the Netherlands using a population-targeted approach to link prevention, care and welfare. DESIGN: Descriptive investigation, based on conversations and structured interviews. METHOD: We searched for initiatives in which providers in the areas of prevention, care and welfare together with health insurers and/or local authorities attempted to provide the 'triple aim': improving the health of the population and the quality of care, and managing costs...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28443057/cognitive-constructivist-approach-in-medical-settings-the-use-of-personal-meaning-questionnaire-for-neurological-patients-personality-investigation
#4
Barbara Poletti, Laura Carelli, Annalisa Lafronza, Federica Solca, Andrea Faini, Andrea Ciammola, Monica Grobberio, Vanessa Raimondi, Rita Pezzati, Rita B Ardito, Vincenzo Silani
Objective: The cognitive-constructivist psychotherapy approach considers the self as a continuous regulation process between present and past experience, in which attributions of meaning is characterized by the use of internal rules. In this conception, everyone would be driven by a specific inner coherence called Personal Meaning Organization (PMO). Such approach has never been applied to neurological patients by means of ad hoc developed tools. We performed an explorative study aimed to characterize personality styles in different neurological conditions within the theoretical framework of cognitive-constructivist model...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28442924/a-framework-for-measuring-self-management-effectiveness-and-health-care-use-among-pediatric-asthma-patients-and-families
#5
REVIEW
Pavani Rangachari
Asthma is associated with substantial health care expenditures, including an estimated US$56 billion per year in direct costs. A recurring theme in the asthma management literature is that costly asthma symptoms, including hospitalizations and multiple emergency department (ED)/outpatient visits, can often be prevented through patient/family adherence to the national (National Institutes of Health Expert Panel Report-3) guidelines for effective self-management of asthma, specifically 1) medication adherence and 2) environmental trigger avoidance, as outlined in the patient's personalized Asthma-Action Plan...
2017: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/28442578/multicentre-non-interventional-study-to-assess-the-profile-of-patients-with-uncontrolled-rhinitis-prescribed-a-novel-formulation-of-azelastine-hydrochloride-and-fluticasone-propionate-in-a-single-spray-in-routine-clinical-practice-in-the-uk
#6
Glenis Scadding, David Price, Tariq El-Shanawany, Shahzada Ahmed, Jaydip Ray, Ravishankar Sargur, Nirmal Kumar
OBJECTIVE: The aims of this study were (1) to characterise the type of patient prescribed MP-AzeFlu (Dymista, a novel formulation of azelastine hydrochloride, fluticasone propionate and excipients in a single spray) in real life in the UK and physicians' reasons for prescribing it and (2) to quantify the personal and societal burden of allergic rhinitis (AR) in the UK prior to MP-AzeFlu prescription. DESIGN, SETTING AND PARTICIPANTS: This multicentre, non-interventional study enrolled patients (n=193) with moderate-to-severe AR and acute symptoms who were eligible to receive treatment with MP-AzeFlu according to its licensed indications...
April 24, 2017: BMJ Open
https://www.readbyqxmd.com/read/28442448/phosphotyrosine-based-phosphoproteomics-scaled-down-to-biopsy-level-for-analysis-of-individual-tumor-biology-and-treatment-selection
#7
Mariette Labots, Johannes C van der Mijn, Robin Beekhof, Sander R Piersma, Richard R de Goeij-de Haas, Thang V Pham, Jaco C Knol, Henk Dekker, Nicole C T van Grieken, Henk M W Verheul, Connie R Jiménez
Mass spectrometry-based phosphoproteomics of cancer cell and tissue lysates provides insight in aberrantly activated signaling pathways and potential drug targets. For improved understanding of individual patient's tumor biology and to allow selection of tyrosine kinase inhibitors in individual patients, phosphoproteomics of small clinical samples should be feasible and reproducible. We aimed to scale down a pTyr-phosphopeptide enrichment protocol to biopsy-level protein input and assess reproducibility and applicability to tumor needle biopsies...
April 22, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28442382/relationship-between-sensorimotor-peripheral-nerve-function-and-indicators-of-cardiovascular-autonomic-function-in-older-adults-from-the-health-aging-and-body-composition-study
#8
Brittney S Lange-Maia, Anne B Newman, John M Jakicic, Jane A Cauley, Robert M Boudreau, Ann V Schwartz, Eleanor M Simonsick, Suzanne Satterfield, Aaron I Vinik, Sasa Zivkovic, Tamara B Harris, Elsa S Strotmeyer
BACKGROUND: Age-related peripheral nervous system (PNS) impairments are highly prevalent in older adults. Although sensorimotor and cardiovascular autonomic function have been shown to be related in persons with diabetes, the nature of the relationship in general community-dwelling older adult populations is unknown. METHODS: Health, Aging and Body Composition participants (n=2399, age=76.5±2.9years, 52% women, 38% black) underwent peripheral nerve testing at the 2000/01 clinic visit...
April 22, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28442336/observed-and-reported-differences-in-child-picky-eating-behavior-between-home-and-childcare-locations
#9
Virginia Luchini, Salma Musaad, Soo-Yeun Lee, Sharon M Donovan
Picky eating (PE) is a common mealtime difficulty that is reported by up to 50% of caregivers. Most of the research to date on PE has focused on parents, even though millions of children also eat meals in home- or center-based childcare settings. Currently, little is known about PE behaviors manifested by the child across the home and childcare settings, or how these behaviors differ between home-based childcare (HBCC) and center-based childcare (CBCC) locations. The objectives of this study were to compare PE behaviors between the child's home and HBCC or CBCC environments, and compare PE behaviors between HBCC and CBCC environments...
April 22, 2017: Appetite
https://www.readbyqxmd.com/read/28442213/pathogenic-cd4-t-cells-in-patients-with-asthma
#10
REVIEW
Lyndsey M Muehling, Monica G Lawrence, Judith A Woodfolk
Asthma encompasses a variety of clinical phenotypes that involve distinct T cell-driven inflammatory processes. Improved understanding of human T-cell biology and the influence of innate cytokines on T-cell responses at the epithelial barrier has led to new asthma paradigms. This review captures recent knowledge on pathogenic CD4(+) T cells in asthmatic patients by drawing on observations in mouse models and human disease. In patients with allergic asthma, TH2 cells promote IgE-mediated sensitization, airway hyperreactivity, and eosinophilia...
April 22, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28441882/work-right-to-right-work-an-automythology-of-chronic-illness-and-work
#11
Lavanya Vijayasingham
Objectives Chronic illness is known to disrupt and redirect the usual course of work trajectories. This article aims to portray the longitudinal course of negotiating work after multiple sclerosis. Methods Using therapy and personal journals to reconstruct memories and experience, an autoethnography is produced and narrated within Campbell's "Hero's Journey" automythology framework. Results The narrative highlights the intrasubjectivity of illness meaning-the changing internal meaning-making and external behavior and decision-making dynamics...
January 1, 2017: Chronic Illness
https://www.readbyqxmd.com/read/28441437/quantitative-modeling-of-responses-to-chronic-ionizing-radiation-exposure-using-targeted-and-non-targeted-effects
#12
Igor Shuryak
The biological effects of chronic ionizing radiation exposure can be difficult to study, but important to understand in order to protect the health of occupationally-exposed persons and victims of radiological accidents or malicious events. They include targeted effects (TE) caused by ionizations within/close to nuclear DNA, and non-targeted effects (NTE) caused by damage to other cell structures and/or activation of stress-signaling pathways in distant cells. Data on radiation damage in animal populations exposed over multiple generations to wide ranges of dose rates after the Chernobyl nuclear-power-plant accident are very useful for enhancing our understanding of these processes...
2017: PloS One
https://www.readbyqxmd.com/read/28440410/a-novel-notch3-mutation-identified-in-patients-with-oral-cancer-by-whole-exome-sequencing
#13
Yanjun Yi, Zhuowei Tian, Houyu Ju, Guoxin Ren, Jingzhou Hu
Oral cancer is a serious disease caused by environmental factors and/or susceptible genes. In the present study, in order to identify useful genetic biomarkers for cancer prediction and prevention, and for personalized treatment, we detected somatic mutations in 5 pairs of oral cancer tissues and blood samples using whole exome sequencing (WES). Finally, we confirmed a novel nonsense single-nucleotide polymorphism (SNP; chr19:15288426A>C) in the NOTCH3 gene with sanger sequencing, which resulted in a N1438T mutation in the protein sequence...
April 25, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28438726/analyzing-unstructured-communication-in-a-computer-mediated-environment-for-adults-with-type-2-diabetes-a-research-protocol
#14
Allison A Lewinski, Ruth A Anderson, Allison A Vorderstrasse, Edwin B Fisher, Wei Pan, Constance M Johnson
BACKGROUND: Individuals with type 2 diabetes have an increased risk for comorbidities such as heart disease, lower limb amputations, stroke, and renal failure. Multiple factors influence development of complications in a person living with type 2 diabetes; however, an individual's self-management behaviors may delay the onset of, or lessen the severity of, these complications. Social support provides personal, informal advice and knowledge that helps individuals initiate and sustain self-management and adherence...
April 24, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28438236/personal-and-macro-systemic-factors-as-predictors-of-quality-of-life-in-chronic-schizophrenia
#15
Yolanda Fontanil-Gómez, María A Alcedo Rodríguez, María I Gutiérrez López
BACKGROUND: The goal of this research was to establish possible predictive factors for both subjective and externally assessed quality of life in people with chronic schizophrenia. METHODS: Sixty-eight people with schizophrenia took part in the study and were assessed using the World Health Organisation Quality of Life Assessment - Brief Version (WHOQOL-BREF), the Quality of Life Scale (QLS), the Positive and Negative Syndrome Scale for Schizophrenia (PANSS), the Global Assessment of Functioning (GAF), the Social Functioning Scale (SFS) tests...
May 2017: Psicothema
https://www.readbyqxmd.com/read/28438227/characterization-of-carbon-monoxide-exposure-during-hurricane-sandy-and-subsequent-nor-easter
#16
Amy Schnall, Royal Law, Amy Heinzerling, Kanta Sircar, Scott Damon, Fuyuen Yip, Josh Schier, Tesfaye Bayleyegn, Amy Wolkin
OBJECTIVE: Carbon monoxide (CO) is an odorless, colorless gas produced by fossil fuel combustion. On October 29, 2012, Hurricane Sandy moved ashore near Atlantic City, New Jersey, causing widespread morbidity and mortality, $30 to $50 billion in economic damage, and 8.5 million households to be without power. The combination of power outages and unusually low temperatures led people to use alternate power sources, placing many at risk for CO exposure. METHODS: We examined Hurricane Sandy-related CO exposures from multiple perspectives to help identify risk factors and develop strategies to prevent future exposures...
April 25, 2017: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/28437725/evaluation-of-ecotoxicological-effects-of-benzophenone-uv-filters-luminescent-bacteria-toxicity-genotoxicity-and-hormonal-activity
#17
Qiuya Zhang, Xiaoyan Ma, Mawuli Dzakpasu, Xiaochang C Wang
The widespread use of organic ultraviolet (UV) filters in personal care products raises concerns about their potentially hazardous effects on human and ecosystem health. In this study, the toxicities of four commonly used benzophenones (BPs) UV filters including benzophenone (BP), 2-Hydroxybenzophenone (2HB), 2-Hydroxy-4-methoxybenzophenone (BP3), and 2-Hydroxy-4-methoxybenzophenone-5-sulfonicacid (BP4) in water were assayed in vitro using Vibrio fischeri, SOS/umu assay, and yeast estrogen screen (YES) assay, as well as in vivo using zebrafish larvae...
April 21, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28436780/truth-axes-and-the-transformation-of-self
#18
Shlomit Yadlin-Gadot
Freud adhered to the idea that psychoanalysis is a science and that truth is one. The transition from a realistic epistemology to an epistemology of subjective idealism in psychoanalytic thought was accompanied by the splintering of the "one" realistic truth into a multiplicity of truths: realistic-correspondent, ideal, subjective-existential, intersubjective, coherent, and pragmatic truths. The present paper, employing the concept of "truth axes," explores these truths as they relate to basic human needs, self- states, and the structuring of subjectivity...
April 2017: Psychoanalytic Review
https://www.readbyqxmd.com/read/28435906/low-back-pain-in-older-adults-risk-factors-management-options-and-future-directions
#19
REVIEW
Arnold Yl Wong, Jaro Karppinen, Dino Samartzis
Low back pain (LBP) is one of the major disabling health conditions among older adults aged 60 years or older. While most causes of LBP among older adults are non-specific and self-limiting, seniors are prone to develop certain LBP pathologies and/or chronic LBP given their age-related physical and psychosocial changes. Unfortunately, no review has previously summarized/discussed various factors that may affect the effective LBP management among older adults. Accordingly, the objectives of the current narrative review were to comprehensively summarize common causes and risk factors (modifiable and non-modifiable) of developing severe/chronic LBP in older adults, to highlight specific issues in assessing and treating seniors with LBP, and to discuss future research directions...
2017: Scoliosis and Spinal Disorders
https://www.readbyqxmd.com/read/28434462/the-effects-of-tai-chi-on-physical-and-psychosocial-function-among-persons-with-multiple-sclerosis-a-systematic-review
#20
REVIEW
Emily Taylor, Ruth E Taylor-Piliae
OBJECTIVES: Conduct a systematic review to evaluate the effects of Tai Chi on physical and psychosocial function among individuals with Multiple Sclerosis. METHODS: An electronic literature search of 12 databases using controlled vocabulary function and keywords from inception through August 2016. All Tai Chi intervention studies assessing physical and psychosocial function among persons with Multiple Sclerosis were included. Study quality was scored using an established tool examining 16 study elements (range=0-32)...
April 2017: Complementary Therapies in Medicine
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