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JOURNAL ARTICLE
Paloma Millan-Billi, Iván Castellví, Laura Martinez-Martinez, Anais Mariscal, Silvia Barril, Miriana D'Alessandro, Tomás Franquet, Diego Castillo
INTRODUCTION: Krebs von den Lungen 6 (KL-6) is a mucin-1 glycoprotein produced by type II pneumocytes. High levels of KL-6 in blood may be found in patients with lung fibrosis. In Asia this biomarker is used for diagnosis and prognosis in interstitial lung diseases (ILD). There is a lack of information regarding KL-6 cut-off point for diagnosis and prognosis in European population. The aim of this study was to establish the cut-off point for serum KL-6 associated with the presence of ILD in the Spanish population...
April 6, 2024: Archivos de Bronconeumología
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JOURNAL ARTICLE
Katarzyna Paczwa, Magdalena Rerych, Katarzyna Romanowska-Próchnicka, Marzena Olesińska, Radosław Różycki, Joanna Gołębiewska
Background: The comparison of retinal perfusion in the eyes of patients with systemic sclerosis (SSc) and in healthy controls using optical coherence tomography angiography (OCTA). The correlation between nailfold capillaroscopy results and OCTA findings among SSc. Methods: The study enrolled 31 patients with systemic sclerosis and 41 healthy controls. OCTA was performed in both groups to assess the retinal vasculature in the superficial (SCP) and deep (DCP) capillary plexuses and the foveal avascular zone (FAZ) area...
March 30, 2024: Journal of Clinical Medicine
#3
JOURNAL ARTICLE
Carrie S Wilson, J Bret Taylor, Ronald M Lewis, David R Notter
Sheep breeders requested that the U.S. Sheep Experiment Station (USSES) to participate in national genetic evaluation through the National Sheep Improvement Program (NSIP). The reasons included the need for (1) a comparison of the productivity of industry and United States Department of Agriculture (USDA) lines, (2) transparency of USDA flocks, (3) genetic ties for NSIP by sampling of industry flocks, and (4) development of premium genetic lines for public release. In response, USSES began to incorporate external sires from NSIP participating flocks into the USSES Targhee flock...
2024: Translational Animal Science
#4
JOURNAL ARTICLE
Sarah L Tansley, Fionnuala McMorrow, Caroline V Cotton, Huzaifa Adamali, Shaney L Barratt, Zoe E Betteridge, Janire Perurena-Prieto, Michael A Gibbons, Raman Kular, Aravinthan Loganathan, Janine A Lamb, Hui Lu, Robert P New, Diane Pratt, Pilar Rivera-Ortega, Ross Sayers, Matthew Steward, Lachlan Stranks, Edward Vital, Lisa G Spencer, Neil J McHugh, Robert G Cooper
BACKGROUND: Autoantibodies are a hallmark feature of Connective Tissue Diseases (CTD). Their presence in patients with idiopathic interstitial lung disease (ILD) may suggest covert CTD. We aimed to determine the prevalence of CTD autoantibodies in patients diagnosed with idiopathic ILD. METHODS: 499 patient sera were analysed: 251 idiopathic pulmonary fibrosis (IPF), 206 idiopathic non-specific interstitial pneumonia (iNSIP) and 42 cryptogenic organising pneumonia (COP)...
April 2, 2024: Clinical Immunology: the Official Journal of the Clinical Immunology Society
#5
JOURNAL ARTICLE
Masato Mima, Seidai Sato, Takayoshi Shinya, Nobuhito Naito, Takatoshi Shoji, Saki Harada, Ryoko Suzue, Kojin Murakami, Kazuya Koyama, Yasuhiko Nishioka
BACKGROUND AND AIM: Anti-aminoacyl-tRNA synthetase (ARS) antibodies form a condition called Antisynthetase syndrome (ASSD). While interstitial lung disease (ILD) is a particularly frequent manifestation of ASSD and is closely associated with morbidity and mortality, few studies have been conducted on its characteristics on high-resolution computed tomography (HRCT). In this study, we clarified the HRCT findings in patients with anti-ARS antibody-positive ILD (ARS-ILD). Methods: The HRCT findings at the time of the ILD diagnosis in 24 ARS-ILD patients were retrospectively evaluated by 2 pulmonologists and one radiologist...
March 26, 2024: Sarcoidosis, Vasculitis, and Diffuse Lung Diseases: Official Journal of WASOG
#6
REVIEW
Noriyuki Enomoto
While idiopathic interstitial pneumonia (IIP) centering on idiopathic pulmonary fibrosis (IPF) is the most prevalent interstitial lung disease (ILD), especially in the older adult population, connective tissue disease (CTD)-related ILD is the second most prevalent ILD. The pathogenesis of IPF is primarily fibrosis, whereas that of other ILDs, particularly CTD-ILD, is mainly inflammation. Therefore, a precise diagnosis is crucial for selecting appropriate treatments, such as antifibrotic or immunosuppressive agents...
May 2024: Respiratory Investigation
#7
JOURNAL ARTICLE
Ahmet Kor, Serdar Can Güven, Selçuk Akan, Funda Eren, Hatice Ecem Konak, Yüksel Maraş, Kevser Orhan, Salim Neşelioğlu, Şükran Erten
BACKGROUND: Recent data show that netrin-1 has a role in development of pulmonary fibrosis. This study was aimed to investigate serum netrin-1 level and its relation to interstitial lung disease(ILD) in patients with rheumatoid arthritis (RA). METHOD: 42 RA patients with RA-ILD, 58 RA patients without RA-ILD (RA non-ILD group), and 61 healthy volunteers were included in this study. The modified DAS28-ESR score was used to calculate disease activity in RA patients...
March 29, 2024: Clinical Biochemistry
#8
REVIEW
A Damiani, M Orlandi, C Bruni, G Bandini, G Lepri, C Scaletti, C Ravaglia, F Frassanito, S Guiducci, A Moggi-Pignone, M Matucci-Cerinic, V Poletti, L Tofani, T V Colby, S Bellando Randone, Sara Tomassetti
BACKGROUND: The prognostic and theragnostic role of histopathological subsets in systemic sclerosis interstitial lung disease (SSc-ILD) have been largely neglected due to the paucity of treatment options and the risks associated with surgical lung biopsy. The novel drugs for the treatment of ILDs and the availability of transbronchial cryobiopsy provide a new clinical scenario making lung biopsy more feasible and a pivotal guide for treatment. The aim of our study was to investigate the usefulness of lung biopsy in SSc ILD with a systematic literature review (SLR)...
March 23, 2024: Respiratory Research
#9
JOURNAL ARTICLE
Katharina Buschulte, Hans-Joachim Kabitz, Lars Hagmeyer, Peter Hammerl, Albert Esselmann, Conrad Wiederhold, Dirk Skowasch, Christoph Stolpe, Marcus Joest, Stefan Veitshans, Marc Höffgen, Phillen Maqhuzu, Larissa Schwarzkopf, Andreas Hellmann, Michael Pfeifer, Jürgen Behr, Rainer Karpavicius, Andreas Günther, Markus Polke, Philipp Höger, Vivien Somogyi, Christoph Lederer, Philipp Markart, Michael Kreuter
BACKGROUND: Interstitial lung diseases (ILD) comprise a heterogeneous group of mainly chronic lung diseases with different disease trajectories. Progression (PF-ILD) occurs in up to 50% of patients and is associated with increased mortality. METHODS: The EXCITING-ILD (Exploring Clinical and Epidemiological Characteristics of Interstitial Lung Diseases) registry was analysed for disease trajectories in different ILD. The course of disease was classified as significant (absolute forced vital capacity FVC decline > 10%) or moderate progression (FVC decline 5-10%), stable disease (FVC decline or increase < 5%) or improvement (FVC increase ≥ 5%) during time in registry...
March 6, 2024: Respiratory Research
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JOURNAL ARTICLE
R X Chen, X N Liu, Y Xu, Y J Shi, M Q Wang, C Shao, H Huang, K Xu, M Z Wang, Z J Xu
Objective: To describe the clinical characteristics of patients with non-small cell lung cancer (NSCLC) who developed checkpoint inhibitor pneumonitis (CIP) and to explore potential prognostic factors. Methods: NSCLC patients who were complicated with CIP after immune checkpoint inhibitors (ICIs) therapy in our institute were enrolled in this study from 1 July 2018 to 30 November 2022. Clinical data of NSCLC-CIP patients were collected, including clinical and radiological features and their outcomes. Results: Among the 70 enrolled NSCLC-CIP patients, there were 57 males (81%) and 13 females (19%)...
March 12, 2024: Chinese Journal of Tuberculosis and Respiratory Diseases
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JOURNAL ARTICLE
Hüseyin Alper Kiziloğlu, Emrah Çevik, Kenan Zengin
BACKGROUND: Interstitial lung diseases (ILD) encompass various disorders characterized by inflammation and/or fibrosis in the lung interstitium. These conditions produce distinct patterns in High-Resolution Computed Tomography (HRCT). OBJECTIVE: We employ a deep learning method to diagnose the most commonly encountered patterns in ILD differentially. MATERIALS AND METHODS: Patients were categorized into usual interstitial pneumonia (UIP), nonspecific interstitial pneumonia (NSIP), and normal lung parenchyma groups...
February 26, 2024: Current medical imaging
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JOURNAL ARTICLE
Leifur Thrainsson, Arnljotur Bjorn Halldorsson, Arnar Bragi Ingason, Helgi J Isaksson, Gunnar Gudmundsson, Tomas Gudbjartsson
BACKGROUND: Surgical lung biopsy (SLB) is required for diagnosis in patients with suspected interstitial lung disease (ILD) if other less invasive diagnostic methods are non-conclusive. We evaluated the outcome of SLB by using centralized databases in a whole-nation patient-cohort. METHODS: A population-based retrospective study on 68 consecutive patients (mean age 58 years, 58.8% males) that underwent SLB in Iceland between the years 2008 and 2020. Patient information was obtained from patient charts and peri- and postoperative complications were registered together with 30- and 90-day mortality...
January 30, 2024: Journal of Thoracic Disease
#13
MULTICENTER STUDY
Noriyuki Enomoto, Shusuke Yazawa, Yasutaka Mochizuka, Atsuki Fukada, Yuko Tanaka, Hyogo Naoi, Yuya Aono, Yusuke Inoue, Hideki Yasui, Masato Karayama, Yuzo Suzuki, Hironao Hozumi, Kazuki Furuhashi, Mikio Toyoshima, Masato Kono, Shiro Imokawa, Takehisa Sano, Taisuke Akamatsu, Naoki Koshimizu, Koshi Yokomura, Hiroyuki Matsuda, Yusuke Kaida, Masahiro Shirai, Kazutaka Mori, Masafumi Masuda, Tomoyuki Fujisawa, Naoki Inui, Yutaro Nakamura, Hiroaki Sugiura, Hiromitsu Sumikawa, Masashi Kitani, Kazuhiro Tabata, Noriyoshi Ogawa, Takafumi Suda
BACKGROUND: Patients with idiopathic interstitial pneumonia (IIP) have a favourable prognosis when they have interstitial pneumonia with autoimmune features (IPAF). However, precise IPAF-related findings from high-resolution computed tomography (HRCT) and lung histopathological specimens and the treatment response have not been fully determined. Therefore, this study was conducted to evaluate the relationship between findings on HRCT or lung histopathological specimens and the progression of interstitial pneumonia in patients with IPAF...
April 2024: Respiratory Medicine
#14
JOURNAL ARTICLE
Deiana Roman, Stela Iurciuc, Alexandru Caraba
(1) Background: Sjögren's syndrome (SS) represents a systemic autoimmune disease whose pathophysiology has yet to be elucidated, though it is known that the inflammatory process encountered in SS is of a systemic nature, with cytokines representing the main mediators for tissue damage. (2) Aim of the study: The aim of the present study is to further the understanding of the link between interleukin serum levels, cytokine serum levels, HRCT findings and the Warrick score (as tools for the evaluation of pulmonary involvement) in patients with pSS...
February 15, 2024: Journal of Clinical Medicine
#15
JOURNAL ARTICLE
Masanori Akira, Narufumi Suganuma
OBJECTIVES: The purpose of this study was to retrospectively assess cystic changes in findings on follow-up CT scans of patients with fibrotic nonspecific interstitial pneumonia (NSIP). METHODS: The initial and last high-resolution CT scans of 58 patients with pathologically proven fibrotic NSIP were evaluated retrospectively. The median follow-up periods were 48 months (range, 12-183 months). The pattern, extent, and distribution of abnormal CT findings were compared with findings in the same region on previous and subsequent CT scans with a focus on cystic lesions...
2024: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
#16
JOURNAL ARTICLE
Boyang Zheng, Daniel-Costin Marinescu, Cameron J Hague, Nestor L Muller, Darra Murphy, Andrew Churg, Joanne L Wright, Amna Al-Arnawoot, Ana-Maria Bilawich, Patrick Bourgouin, Gerard Cox, Celine Durand, Tracy Elliot, Jennifer Ellis, Jolene H Fisher, Derek Fladeland, Amanda Grant-Orser, Gillian C Goobie, Zachary Guenther, Ehsan Haider, Nathan Hambly, James Huynh, Kerri A Johannson, Geoffrey Karjala, Nasreen Khalil, Martin Kolb, Jonathon Leipsic, Stacey Lok, Sarah MacIsaac, Micheal McInnis, Helene Manganas, Veronica Marcoux, John Mayo, Julie Morisset, Ciaran Scallan, Tony Sedlic, Shane Shapera, Kelly Sun, Victoria Tan, Alyson W Wong, Christopher J Ryerson
OBJECTIVES: Interstitial lung disease (ILD) in connective tissue diseases (CTD) have highly variable morphology. We aimed to identify imaging features and their impact on ILD progression, mortality and immunosuppression response. METHODS: Patients with CTD-ILD had high-resolution chest computed tomography (HRCT) reviewed by expert radiologists blinded to clinical data for overall imaging pattern (usual interstitial pneumonia [UIP]; non-specific interstitial pneumonia [NSIP]; organizing pneumonia [OP]; fibrotic hypersensitivity pneumonitis [fHP]; and other)...
February 9, 2024: Rheumatology
#17
JOURNAL ARTICLE
Wei Wei, Wei Zou, Wei Han, Jingjing Liu
OBJECTIVE: This study aimed to evaluate the therapeutic impact of pirfenidone in patients with nonspecific interstitial pneumonia (NSIP) secondary to Sjögren's syndrome, comparing its effectiveness against conventional treatments. METHODS: A controlled clinical trial was conducted on a cohort of patients diagnosed with primary Sjögren's syndrome complicated by interstitial lung disease. The study included a total of 120 patients, divided equally into two groups: a control group comprising 60 patients and an observation group with another 60 patients...
January 1, 2024: Alternative Therapies in Health and Medicine
#18
Gastón Larrea Avanzini, Maritza Campoverde Encalada
We present the case of a 35-year-old male patient, sandblaster for eight years, recently diagnosed with pulmonary tuberculosis and systemic sclerosis, who was admitted with dyspnea and poor general condition. Chest X-ray showed a grade I pneumothorax, and on the chest tomography he presented confluent hyperdense masses associated with a pattern of non- specific interstitial pneumonia (NSIP), findings compatible with complicated silicosis. Due to the advanced clinical stage, neither invasive diagnostic test nor pulmonary function test could be performed...
2024: Medicina
#19
JOURNAL ARTICLE
Hiroyuki Katsuragawa, Shinji Sumiyoshi, Naoya Ikegami, Seishu Hashimoto, Takashi Hajiro, Yoshio Taguchi, Yoichiro Kobashi, Hironori Haga, Akihiko Yoshizawa
Differentiating between idiopathic interstitial pneumonia (IIP) and secondary interstitial pneumonia, particularly connective tissue disease-associated interstitial lung disease (CTD-ILD), can be challenging histopathologically, and there may be discrepancies among pathologists. While surgical lung biopsy has traditionally been considered the gold standard for diagnosing interstitial pneumonia, the usefulness of transbronchial lung cryobiopsy (TBLC) has been reported. If TBLC could effectively distinguish between primary and secondary diseases, it would provide a less invasive option for patients...
January 2, 2024: Pathology, Research and Practice
#20
REVIEW
Mitsuhiro Akiyama, Waleed Alshehri, Yuko Kaneko
Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammatory synovitis, eventually leading to joint destruction. Remarkable advancements in the emergence of molecular targeted therapies and the treatment strategy based on treat-to-target have made it possible for patients to lead their daily lives without disabilities. Specifically, early diagnosis and appropriate treatment without missing a 'window of opportunity' are crucial for improving joint outcomes. On the other hand, interstitial lung disease (ILD) is an extra-articular complication of RA and has an impact on life prognosis...
December 10, 2023: Autoimmunity Reviews
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