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https://www.readbyqxmd.com/read/28735356/evaluation-of-anthelmintic-antimicrobial-and-antioxidant-activity-of-chenopodium-album
#1
Bashir A Lone, M Z Chishti, Fayaz Ahmad Bhat, Hidayatullah Tak, Suhaib A Bandh, Abida Khan
The objective of this study was to evaluate the anthelmintic, antimicrobial and antioxidant activities of Chenopodium album against gastrointestinal nematodes of sheep and some pathogenic microbes. A worm motility inhibition assay was used for in vitro study, and a faecal egg count reduction assay was used for an in vivo study. Various concentrations ranging from 100 to 500 μg/ml of the extract were subjected to antimicrobial screening by disc diffusion method against four selected bacterial (Staphylococcus aureus, Klebsiella pneumoniae, Pseudomonas multocida and Escherichia coli) and two fungal (Aspergillus flavus and Candida albicans) strains in order to estimate the medicinal potential of the herb...
July 22, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/28732272/screening-of-the-open-scaffolds-collection-from-compounds-australia-identifies-a-new-chemical-entity-with-anthelmintic-activities-against-different-developmental-stages-of-the-barber-s-pole-worm-and-other-parasitic-nematodes
#2
Sarah Preston, Yaqing Jiao, Jonathan B Baell, Jennifer Keiser, Simon Crawford, Anson V Koehler, Tao Wang, Moana M Simpson, Ray M Kaplan, Karla J Cowley, Kaylene J Simpson, Andreas Hofmann, Abdul Jabbar, Robin B Gasser
The discovery and development of novel anthelmintic classes is essential to sustain the control of socioeconomically important parasitic worms of humans and animals. With the aim of offering novel, lead-like scaffolds for drug discovery, Compounds Australia released the 'Open Scaffolds' collection containing 33,999 compounds, with extensive information available on the physicochemical properties of these chemicals. In the present study, we screened 14,464 prioritised compounds from the 'Open Scaffolds' collection against the exsheathed third-stage larvae (xL3s) of Haemonchus contortus using recently developed whole-organism screening assays...
May 28, 2017: International Journal for Parasitology, Drugs and Drug Resistance
https://www.readbyqxmd.com/read/28717850/physio-biochemical-parameters-a-potential-tool-for-target-selective-treatment-of-haemonchosis-in-the-small-ruminants
#3
Bhupamani Das, Niranjan Kumar, Mehul M Jadav, Jayesh B Solanki, T K S Rao
This study aims to evaluate the conjunctiva colour-based FAMACHA score (FS) coupled with a body condition score (BCS), haemogram and stressor hormone level estimation, in identifying post-mortem (PM)/coproscopically proven individuals wanting therapy for economically important gastrointestinal (GI) helminths, Haemonchus contortus, in the small ruminants. The incidence of haemonchosis was significantly (p < 0.05) higher (60.81%) in the ruminants with FS = 3. The H. contortus count in the animals with FS 2, 3 and 4 was 23...
July 17, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/28717849/an-assessment-of-benzimidazole-resistance-against-caprine-nematodes-in-central-india
#4
A K Dixit, G Das, Pooja Dixit, A P Singh, N K Kumbhakar, M Sankar, R L Sharma
Current status of resistance to benzimidazole (BZ) group of anthelmintic drugs against caprine nematodes in Central India at Amanala goat farm, Jabalpur, Madhya Pradesh (M. P.), was systematically investigated using faecal egg count reduction (FECR) test and egg hatch test (EHT). Besides, allele-specific PCR (AS-PCR) was deployed to ascertain the susceptible genotype (alleles) especially of the Haemonchus contortus. Randomly selected 30 goats, irrespective of age and sex, were divided into three groups of 10 each, to serve as treated and untreated controls...
July 17, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/28687609/deguelin-exerts-potent-nematocidal-activity-via-the-mitochondrial-respiratory-chain
#5
Sarah Preston, Pasi K Korhonen, Laurent Mouchiroud, Matteo Cornaglia, Sean L McGee, Neil D Young, Rohan A Davis, Simon Crawford, Cameron Nowell, Brendan R E Ansell, Gillian M Fisher, Katherine T Andrews, Bill C H Chang, Martin A M Gijs, Paul W Sternberg, Johan Auwerx, Jonathan Baell, Andreas Hofmann, Abdul Jabbar, Robin B Gasser
As a result of limited classes of anthelmintics and an over-reliance on chemical control, there is a great need to discover new compounds to combat drug resistance in parasitic nematodes. Here, we show that deguelin, a plant-derived rotenoid, selectively and potently inhibits the motility and development of nematodes, which supports its potential as a lead candidate for drug development. Furthermore, we demonstrate that deguelin treatment significantly increases gene transcription that is associated with energy metabolism, particularly oxidative phosphorylation and mito-ribosomal protein production before inhibiting motility...
July 7, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28679424/screening-of-the-stasis-box-identifies-two-kinase-inhibitors-under-pharmaceutical-development-with-activity-against-haemonchus-contortus
#6
Yaqing Jiao, Sarah Preston, Anson V Koehler, Andreas J Stroehlein, Bill C H Chang, Kaylene J Simpson, Karla J Cowley, Michael J Palmer, Benoît Laleu, Timothy N C Wells, Abdul Jabbar, Robin B Gasser
BACKGROUND: In partnership with the Medicines for Malaria Venture (MMV), we screened a collection ('Stasis Box') of 400 compounds (which have been in clinical development but have not been approved for illnesses other than neglected infectious diseases) for inhibitory activity against Haemonchus contortus, in order to attempt to repurpose some of the compounds to parasitic nematodes. METHODS: We assessed the inhibition of compounds on the motility and/or development of exsheathed third-stage (xL3s) and fourth-stage (L4) larvae of H...
July 5, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28651566/arginine-kinase-from-haemonchus-contortus-decreased-the-proliferation-and-increased-the-apoptosis-of-goat-pbmcs-in-vitro
#7
Muhammad Ehsan, WenXiang Gao, Javaid Ali Gadahi, MingMin Lu, XinChao Liu, YuJian Wang, RuoFeng Yan, LiXin Xu, XiaoKai Song, XiangRui Li
BACKGROUND: Arginine kinase (AK), an important member of phosphagen kinase family has been extensively studied in various vertebrates and invertebrates. Immunologically, AKs are important constituents of different body parts, involved in various biological and cellular functions, and considered as immune-modulator and effector for pro-inflammatory cytokines. However, immunoregulatory changes of host cells triggered by AK protein of Haemonchus contortus, a parasitic nematode of ruminants, are still unknown...
June 26, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28615838/immunodiagnosis-of-haemonchus-contortus-infection-in-sheep-by-counter-immuno-electrophoresis-using-somatic-antigen
#8
Ananda K Javare Gowda
The present study was undertaken for the immuno-diagnosis of Haemonchus contortus infection in sheep by counter immuno-electrophoresis (CIEP) using crude somatic antigen. Adult worms of H. contortus were found in 57 out of 100 abomasums screened. A total of 250 serum samples which includes, 100 serum from local abattoir in and around Shimoga region from the sheep from which the abomasums were collected for H. contortus worms and 150 serum from the migratory sheep were collected to detect the circulating antibody of H...
June 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/28595672/in-vitro-larvicidal-and-in-vivo-anthelmintic-effects-of-oxalis-tetraphylla-oxalidaceae-hydroalcoholic-extract-against-haemonchus-contortus-in-lambs
#9
B J González-Cruz, M Rodríguez-Labastida, M González-Cortázar, A Zamilpa, M E López-Arellano, L Aguilar-Marcelino, R González-Garduño, J F J Torres-Acosta, A Olmedo-Juárez, P Mendoza-de Gives
The in vitro larvicidal and in vivo anthelmintic effects of Oxalis tetraphylla hydroalcoholic extract (HE), against Haemonchus contortus in experimentally infected lambs, were assessed. We used a microtitration plate method, comprising the following two stages. Stage 1: 20 μl of water containing 200 sheathed H. contortus infective larvae (ShHcl) were deposited in every well of three series; then, the series 2 and 3 wells were treated with 80 μl 1% ivermectin and O. tetraphylla HE at 20 mg/ml, respectively...
June 9, 2017: Journal of Helminthology
https://www.readbyqxmd.com/read/28579030/broad-spectrum-anthelmintic-resistance-of-haemonchus-contortus-in-northern-nsw-of-australia
#10
Jane Lamb, Tim Elliott, Michael Chambers, Bruce Chick
On a sheep farm in Northern New South Wales (NSW) of Australia a degree of anthelmintic resistance was suspected. With noticeable clinical signs of infection and sheep not responding to treatment, a faecal egg count reduction test was conducted to ascertain the broad spectrum of anthelmintic resistance at this farm. A number of classes of anthelmintics were assessed including organophosphate, macrocyclic lactone (ML) and in combination an ML, benzimidazole, levamisole and salicylanilide. In addition, the more recently registered classes of anthelmintics, monepantel (amino-acetonitrile derivative) and derquantel/abamectin combination (spiroindole+ML) were included...
July 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28579029/pharmacokinetics-and-anthelmintic-efficacy-of-injectable-eprinomectin-in-goats
#11
C Briqué-Pellet, N Ravinet, Y Quenet, M Alvinerie, C Chartier
The objective of this study was to assess the pharmacokinetics and the anthelmintic efficacy of eprinomectin (Eprecis(®) 20mg/mL) following subcutaneous administration to goats. Forty non-lactating female Alpine goats aged between one and three years and weighing between 32.7 and 59.5kg, were randomly allocated to one of the following groups (8 animals per group): two groups were not infected and were treated at a dose of either 0.2 or 0.4mg/kg BW of eprinomectin, two groups were experimentally infected with nematodes and treated at 0...
July 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28578091/in%C3%A2-vitro-assessment-of-argemone-mexicana-taraxacum-officinale-ruta-chalepensis-and-tagetes-filifolia-against-haemonchus-contortus-nematode-eggs-and-infective-l3-larvae
#12
Gabriela Jasso Díaz, Glafiro Torres Hernández, Alejandro Zamilpa, Carlos Miguel Becerril Pérez, J Efrén Ramírez Bribiesca, Omar Hernández Mendo, Hussein Sánchez Arroyo, Manasés González Cortazar, Pedro Mendoza de Gives
Argemone mexicana, Taraxacum officinale, Ruta chalepensis and Tagetes filifolia are plants with deworming potential. The purpose of this study was to evaluate methanolic extracts of aerial parts of these plants against Haemonchus contortus eggs and infective larvae (L3) and identify compounds responsible for the anthelmintic activity. In vitro probes were performed to identify the anthelmintic activity of plant extracts: egg hatching inhibition (EHI) and larvae mortality. Open column Chromatography was used to bio-guided fractionation of the extract, which shows the best anthelmintic effect...
May 31, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28576342/development-of-a-colloidal-gold-immunochromatographic-strip-based-on-hsp70-for-the-rapid-detection-of-echinococcus-granulosus-in-sheep
#13
Xunhui Zhuo, Yingchao Yu, Xueqiu Chen, Zhuangzhi Zhang, Yi Yang, Aifang Du
Echinococcus granulosus is the causative pathogen of cystic echinococcosis, a serious disease endangering human and animal health. In this study, an immunochromatographic strip was developed based on the recombinant protein Heat shock protein 70 (HSP70) for the serological detection of E. granulosus. The protocol completes within 20min requiring no specialized equipment or chemical reagents, while specificity tests confirmed no cross-reactivity with positive serum of Fasciola hepatica, Haemonchus contortus, Peste des petits ruminants virus (PPRV) and Foot-and-mouth disease virus (FMDV)...
June 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28576338/susceptibility-of-ten-haemonchus-contortus-isolates-from-different-geographical-origins-towards-acetone-water-extracts-of-polyphenol-rich-plants-part-2-infective-l3-larvae
#14
J I Chan-Pérez, J F J Torres-Acosta, C A Sandoval-Castro, G S Castañeda-Ramírez, G Vilarem, C Mathieu, H Hoste
This study explored the variation in susceptibility to acetone:water plant extracts between infective larvae (L3) of ten Haemonchus contortus isolates from different geographical origin. The L3 of 10 different isolates were exposed either to the acetone:water extract of a temperate plant (Onobrychis viciifolia) or a tropical plant (Acacia pennatula) and were evaluated with the larval exsheathment inhibition assay (LEIA). The L3 of each isolate were incubated with different concentrations of each extract (0, 25, 50, 100, 200, 400, 600, 800, 1000 and 1200μg/mL of phosphate buffered saline (PBS))...
June 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28569174/assessing-the-anthelmintic-activity-of-pyrazole-5-carboxamide-derivatives-against-haemonchus-contortus
#15
Yaqing Jiao, Sarah Preston, Hongjian Song, Abdul Jabbar, Yuxiu Liu, Jonathan Baell, Andreas Hofmann, Dana Hutchinson, Tao Wang, Anson V Koehler, Gillian M Fisher, Katherine T Andrews, Benoît Laleu, Michael J Palmer, Jeremy N Burrows, Timothy N C Wells, Qingmin Wang, Robin B Gasser
BACKGROUND: In this study, we tested five series of pyrazole-5-carboxamide compounds (n = 55) for activity against parasitic stages of the nematode Haemonchus contortus (barber's pole worm), one of the most pathogenic parasites of ruminants. METHODS: In an optimised, whole-organism screening assay, using exsheathed third-stage (xL3) and fourth-stage (L4) larvae, we measured the inhibition of larval motility and development of H. contortus. RESULTS: Amongst the 55 compounds, we identified two compounds (designated a-15 and a-17) that reproducibly inhibit xL3 motility as well as L4 motility and development, with IC50 values ranging between ~3...
May 31, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28558828/eprinomectin-pour-on-eprinex%C3%A2-pour-on-merial-efficacy-against-gastrointestinal-and-pulmonary-nematodes-and-pharmacokinetics-in-sheep
#16
Dietmar Hamel, Antonio Bosco, Laura Rinaldi, Giuseppe Cringoli, Karl-Heinz Kaulfuß, Michael Kellermann, James Fischer, Hailun Wang, Katrin Kley, Sandra Mayr, Renate Rauh, Martin Visser, Thea Wiefel, Becky Fankhauser, Steffen Rehbein
BACKGROUND: The anthelmintic efficacy of the 0.5% w/v topical formulation of eprinomectin (EPN), EPRINEX® Pour-on (Merial) when administered at 1 mg/kg body weight was evaluated in sheep in two dose confirmation laboratory studies and one multicenter field study. In addition, the pharmacokinetics of EPN when administered at that dosage to adult sheep was determined. RESULTS: In the two dose confirmation studies, which included 10 sheep each, sheep treated with topical EPN had significantly (p < 0...
May 30, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28552633/early-and-late-gene-expression-profiles-of-the-ovine-mucosa-in-response-to-haemonchus-contortus-infection-employing-illumina-rna-seq-technology
#17
Saeed El-Ashram, Ibrahim Al Nasr, Maged El-Kemary, Rashid Mehmood, Min Hu, Xun Suo
We conducted herein transcriptome sequencing of the ovine abomasal tissues using the Illumina HiSeq 4000 platform to segregate early and late H. contortus-infected sheep (7 and 50days post-infected groups, respectively) from the control naive ones. A total of 548, 357 and 7 were substantially induced genes in 7days post-infection versus uninfected-control group, 50days post-infection versus 7days post-infection (7dpi), and 50days post-infection (50dpi) versus uninfected-control group, respectively. However, a total of 301, 355 and 11 were significantly repressed genes between 7dpi versus uninfected-control group, 50dpi versus 7dpi, and 50dpi versus uninfected-control group, correspondingly...
May 24, 2017: Parasitology International
https://www.readbyqxmd.com/read/28501715/mutations-in-the-hco-mptl-1-gene-in-a-field-derived-monepantel-resistant-isolate-of-haemonchus-contortus
#18
Neil H Bagnall, Angela Ruffell, Ali Raza, Timothy P Elliott, Jane Lamb, Peter W Hunt, Andrew C Kotze
Resistance to the anthelmintic drug monepantel (Zolvix(®)) has emerged in parasitic worms infecting sheep and goats. The mechanism of resistance in these cases is unknown. The drug targets nicotinic acetylcholine receptors belonging to the nematode-specific DEG-3 subfamily. We examined the receptor gene, Hco-mptl-1, in a highly Zolvix(®)-resistant and a -susceptible isolate of the parasitic nematode Haemonchus contortus. cDNA coding for the full length receptor protein (Hco-MPTL-1) was present in all clones prepared from a pool of susceptible larvae (21/21 clones) and approximately 50% of those from the resistant isolate (17/33)...
August 2017: International Journal for Parasitology, Drugs and Drug Resistance
https://www.readbyqxmd.com/read/28495198/phenotypic-expression-of-parasite-susceptibility-to-haemonchus-contortus-in-pelibuey-sheep
#19
N F Ojeda-Robertos, J F J Torres-Acosta, R González-Garduño, D R Notter
The objective of this study was to determine if the mean faecal egg count (FEC) from a first experimental Haemonchus contortus infection could be used to classify parasite-naïve Pelibuey hair sheep as parasite-resistant high responders and parasite-susceptible low responders. Twenty 6- to 7-month-old Pelibuey male sheep raised free of gastrointestinal nematodes were challenged with 7500±1412 H. contortus L3 larvae administrated orally on day 0 of the study. Faecal samples from each lamb were obtained daily from 21 to 41days post-infection (Stage I)...
May 30, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28495192/effect-of-creep-fed-supplement-on-the-susceptibility-of-pasture-grazed-suckling-lambs-to-gastrointestinal-helminths
#20
Gleice Kelli Ayardes de Melo, Camila Celeste Brandão Ferreira Ítavo, Kedma Leonora Silva Monteiro, Jonilson Araújo da Silva, Pâmila Carolini Gonçalves da Silva, Luís Carlos Vinhas Ítavo, Dyego Gonçalves Lino Borges, Fernando de Almeida Borges
This study evaluated the effect of creep feeding a protein supplement on the susceptibility of suckling lambs to infection with gastrointestinal helminths. Male and female lambs were grazed on Brachiaria spp. pastures next to their mothers. Animals were allocated to one of two treatments: creep feeding (261g/d) and control (no supplementation). The trial period was the suckling of lambs during two years of study: May-October 2013 and March-July 2014. Supplementary creep feeding of lambs improved animal performance (P<0...
May 30, 2017: Veterinary Parasitology
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