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haemonchus contortus

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https://www.readbyqxmd.com/read/28615838/immunodiagnosis-of-haemonchus-contortus-infection-in-sheep-by-counter-immuno-electrophoresis-using-somatic-antigen
#1
Ananda K Javare Gowda
The present study was undertaken for the immuno-diagnosis of Haemonchus contortus infection in sheep by counter immuno-electrophoresis (CIEP) using crude somatic antigen. Adult worms of H. contortus were found in 57 out of 100 abomasums screened. A total of 250 serum samples which includes, 100 serum from local abattoir in and around Shimoga region from the sheep from which the abomasums were collected for H. contortus worms and 150 serum from the migratory sheep were collected to detect the circulating antibody of H...
June 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/28595672/in-vitro-larvicidal-and-in-vivo-anthelmintic-effects-of-oxalis-tetraphylla-oxalidaceae-hydroalcoholic-extract-against-haemonchus-contortus-in-lambs
#2
B J González-Cruz, M Rodríguez-Labastida, M González-Cortázar, A Zamilpa, M E López-Arellano, L Aguilar-Marcelino, R González-Garduño, J F J Torres-Acosta, A Olmedo-Juárez, P Mendoza-de Gives
The in vitro larvicidal and in vivo anthelmintic effects of Oxalis tetraphylla hydroalcoholic extract (HE), against Haemonchus contortus in experimentally infected lambs, were assessed. We used a microtitration plate method, comprising the following two stages. Stage 1: 20 μl of water containing 200 sheathed H. contortus infective larvae (ShHcl) were deposited in every well of three series; then, the series 2 and 3 wells were treated with 80 μl 1% ivermectin and O. tetraphylla HE at 20 mg/ml, respectively...
June 9, 2017: Journal of Helminthology
https://www.readbyqxmd.com/read/28579030/broad-spectrum-anthelmintic-resistance-of-haemonchus-contortus-in-northern-nsw-of-australia
#3
Jane Lamb, Tim Elliott, Michael Chambers, Bruce Chick
On a sheep farm in Northern New South Wales (NSW) of Australia a degree of anthelmintic resistance was suspected. With noticeable clinical signs of infection and sheep not responding to treatment, a faecal egg count reduction test was conducted to ascertain the broad spectrum of anthelmintic resistance at this farm. A number of classes of anthelmintics were assessed including organophosphate, macrocyclic lactone (ML) and in combination an ML, benzimidazole, levamisole and salicylanilide. In addition, the more recently registered classes of anthelmintics, monepantel (amino-acetonitrile derivative) and derquantel/abamectin combination (spiroindole+ML) were included...
July 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28579029/pharmacokinetics-and-anthelmintic-efficacy-of-injectable-eprinomectin-in-goats
#4
C Briqué-Pellet, N Ravinet, Y Quenet, M Alvinerie, C Chartier
The objective of this study was to assess the pharmacokinetics and the anthelmintic efficacy of eprinomectin (Eprecis(®) 20mg/mL) following subcutaneous administration to goats. Forty non-lactating female Alpine goats aged between one and three years and weighing between 32.7 and 59.5kg, were randomly allocated to one of the following groups (8 animals per group): two groups were not infected and were treated at a dose of either 0.2 or 0.4mg/kg BW of eprinomectin, two groups were experimentally infected with nematodes and treated at 0...
July 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28578091/in%C3%A2-vitro-assessment-of-argemone-mexicana-taraxacum-officinale-ruta-chalepensis-and-tagetes-filifolia-against-haemonchus-contortus-nematode-eggs-and-infective-l3-larvae
#5
Gabriela Jasso Díaz, Glafiro Torres Hernández, Alejandro Zamilpa, Carlos Miguel Becerril Pérez, J Efrén Ramírez Bribiesca, Omar Hernández Mendo, Hussein Sánchez Arroyo, Manasés González Cortazar, Pedro Mendoza de Gives
Argemone mexicana, Taraxacum officinale, Ruta chalepensis and Tagetes filifolia are plants with deworming potential. The purpose of this study was to evaluate methanolic extracts of aerial parts of these plants against Haemonchus contortus eggs and infective larvae (L3) and identify compounds responsible for the anthelmintic activity. In vitro probes were performed to identify the anthelmintic activity of plant extracts: egg hatching inhibition (EHI) and larvae mortality. Open column Chromatography was used to bio-guided fractionation of the extract, which shows the best anthelmintic effect...
May 31, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28576342/development-of-a-colloidal-gold-immunochromatographic-strip-based-on-hsp70-for-the-rapid-detection-of-echinococcus-granulosus-in-sheep
#6
Xunhui Zhuo, Yingchao Yu, Xueqiu Chen, Zhuangzhi Zhang, Yi Yang, Aifang Du
Echinococcus granulosus is the causative pathogen of cystic echinococcosis, a serious disease endangering human and animal health. In this study, an immunochromatographic strip was developed based on the recombinant protein Heat shock protein 70 (HSP70) for the serological detection of E. granulosus. The protocol completes within 20min requiring no specialized equipment or chemical reagents, while specificity tests confirmed no cross-reactivity with positive serum of Fasciola hepatica, Haemonchus contortus, Peste des petits ruminants virus (PPRV) and Foot-and-mouth disease virus (FMDV)...
June 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28576338/susceptibility-of-ten-haemonchus-contortus-isolates-from-different-geographical-origins-towards-acetone-water-extracts-of-polyphenol-rich-plants-part-2-infective-l3-larvae
#7
J I Chan-Pérez, J F J Torres-Acosta, C A Sandoval-Castro, G S Castañeda-Ramírez, G Vilarem, C Mathieu, H Hoste
This study explored the variation in susceptibility to acetone:water plant extracts between infective larvae (L3) of ten Haemonchus contortus isolates from different geographical origin. The L3 of 10 different isolates were exposed either to the acetone:water extract of a temperate plant (Onobrychis viciifolia) or a tropical plant (Acacia pennatula) and were evaluated with the larval exsheathment inhibition assay (LEIA). The L3 of each isolate were incubated with different concentrations of each extract (0, 25, 50, 100, 200, 400, 600, 800, 1000 and 1200μg/mL of phosphate buffered saline (PBS))...
June 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28569174/assessing-the-anthelmintic-activity-of-pyrazole-5-carboxamide-derivatives-against-haemonchus-contortus
#8
Yaqing Jiao, Sarah Preston, Hongjian Song, Abdul Jabbar, Yuxiu Liu, Jonathan Baell, Andreas Hofmann, Dana Hutchinson, Tao Wang, Anson V Koehler, Gillian M Fisher, Katherine T Andrews, Benoît Laleu, Michael J Palmer, Jeremy N Burrows, Timothy N C Wells, Qingmin Wang, Robin B Gasser
BACKGROUND: In this study, we tested five series of pyrazole-5-carboxamide compounds (n = 55) for activity against parasitic stages of the nematode Haemonchus contortus (barber's pole worm), one of the most pathogenic parasites of ruminants. METHODS: In an optimised, whole-organism screening assay, using exsheathed third-stage (xL3) and fourth-stage (L4) larvae, we measured the inhibition of larval motility and development of H. contortus. RESULTS: Amongst the 55 compounds, we identified two compounds (designated a-15 and a-17) that reproducibly inhibit xL3 motility as well as L4 motility and development, with IC50 values ranging between ~3...
May 31, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28558828/eprinomectin-pour-on-eprinex%C3%A2-pour-on-merial-efficacy-against-gastrointestinal-and-pulmonary-nematodes-and-pharmacokinetics-in-sheep
#9
Dietmar Hamel, Antonio Bosco, Laura Rinaldi, Giuseppe Cringoli, Karl-Heinz Kaulfuß, Michael Kellermann, James Fischer, Hailun Wang, Katrin Kley, Sandra Mayr, Renate Rauh, Martin Visser, Thea Wiefel, Becky Fankhauser, Steffen Rehbein
BACKGROUND: The anthelmintic efficacy of the 0.5% w/v topical formulation of eprinomectin (EPN), EPRINEX® Pour-on (Merial) when administered at 1 mg/kg body weight was evaluated in sheep in two dose confirmation laboratory studies and one multicenter field study. In addition, the pharmacokinetics of EPN when administered at that dosage to adult sheep was determined. RESULTS: In the two dose confirmation studies, which included 10 sheep each, sheep treated with topical EPN had significantly (p < 0...
May 30, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28552633/early-and-late-gene-expression-profiles-of-the-ovine-mucosa-in-response-to-haemonchus-contortus-infection-employing-illumina-rna-seq-technology
#10
Saeed El-Ashram, Ibrahim Al Nasr
We conducted herein transcriptome sequencing of the ovine abomasal tissues using the Illumina HiSeq 4000 platform to segregate early and late H. contortus-infected sheep (7 and 50days post-infected groups, respectively) from the control naive ones. A total of 548, 357 and 7 were substantially induced genes in 7days post-infection versus uninfected-control group, 50days post-infection versus 7days post-infection (7dpi), and 50days post-infection (7dpi) versus uninfected-control group, respectively. However, a total of 301, 355 and 11 were significantly repressed genes between 7dpi versus uninfected-control group, 50dpi versus 7dpi, and 50dpi versus uninfected-control group, correspondingly...
May 24, 2017: Parasitology International
https://www.readbyqxmd.com/read/28501715/mutations-in-the-hco-mptl-1-gene-in-a-field-derived-monepantel-resistant-isolate-of-haemonchus-contortus
#11
Neil H Bagnall, Angela Ruffell, Ali Raza, Timothy P Elliott, Jane Lamb, Peter W Hunt, Andrew C Kotze
Resistance to the anthelmintic drug monepantel (Zolvix(®)) has emerged in parasitic worms infecting sheep and goats. The mechanism of resistance in these cases is unknown. The drug targets nicotinic acetylcholine receptors belonging to the nematode-specific DEG-3 subfamily. We examined the receptor gene, Hco-mptl-1, in a highly Zolvix(®)-resistant and a -susceptible isolate of the parasitic nematode Haemonchus contortus. cDNA coding for the full length receptor protein (Hco-MPTL-1) was present in all clones prepared from a pool of susceptible larvae (21/21 clones) and approximately 50% of those from the resistant isolate (17/33)...
May 4, 2017: International Journal for Parasitology, Drugs and Drug Resistance
https://www.readbyqxmd.com/read/28495198/phenotypic-expression-of-parasite-susceptibility-to-haemonchus-contortus-in-pelibuey-sheep
#12
N F Ojeda-Robertos, J F J Torres-Acosta, R González-Garduño, D R Notter
The objective of this study was to determine if the mean faecal egg count (FEC) from a first experimental Haemonchus contortus infection could be used to classify parasite-naïve Pelibuey hair sheep as parasite-resistant high responders and parasite-susceptible low responders. Twenty 6- to 7-month-old Pelibuey male sheep raised free of gastrointestinal nematodes were challenged with 7500±1412 H. contortus L3 larvae administrated orally on day 0 of the study. Faecal samples from each lamb were obtained daily from 21 to 41days post-infection (Stage I)...
May 30, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28495192/effect-of-creep-fed-supplement-on-the-susceptibility-of-pasture-grazed-suckling-lambs-to-gastrointestinal-helminths
#13
Gleice Kelli Ayardes de Melo, Camila Celeste Brandão Ferreira Ítavo, Kedma Leonora Silva Monteiro, Jonilson Araújo da Silva, Pâmila Carolini Gonçalves da Silva, Luís Carlos Vinhas Ítavo, Dyego Gonçalves Lino Borges, Fernando de Almeida Borges
This study evaluated the effect of creep feeding a protein supplement on the susceptibility of suckling lambs to infection with gastrointestinal helminths. Male and female lambs were grazed on Brachiaria spp. pastures next to their mothers. Animals were allocated to one of two treatments: creep feeding (261g/d) and control (no supplementation). The trial period was the suckling of lambs during two years of study: May-October 2013 and March-July 2014. Supplementary creep feeding of lambs improved animal performance (P<0...
May 30, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28484087/modulation-of-goat-monocyte-function-by-hccyst-2-a-secreted-cystatin-from-haemonchus-contortus
#14
Yujian Wang, Yuling Wen, Shuai Wang, Muhammad Ehsan, RuoFeng Yan, XiaoKai Song, LiXin Xu, XiangRui Li
Modulation and suppression of the host immune response by nematode parasites have been reported extensively and the cysteine protease inhibitor (cystatin) is identified as one of the major immunomodulator. In the present study, we cloned and produced recombinant cystatin protein from nematode parasite Haemonchus contortus (rHCcyst-2) and investigated its immunomodulatory effects on goat monocyte. rHCcyst-2 protein is biologically functional as shown by its ability to inhibit the protease activity of cathepsin L, cathepsin B and papain...
April 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/28480837/anthelmintic-activity-of-tunisian-chamomile-matricaria-recutita-l-against-haemonchus-contortus
#15
S Hajaji, D Alimi, M A Jabri, S Abuseir, M Gharbi, H Akkari
The chemical treatment of gastrointestinal parasitic diseases has been undermined by increasing resistance and high toxicity. There is an urgent need to search for alternative natural sources for the treatment of such parasites. In this respect, the present study aims to quantify phenolic compounds of chamomile (Matricaria recutita L.) and to study their in vitro anti-oxidant and anthelmintic activities in solvents with increasing polarity. In vitro determination of anti-oxidant capacity was carried out using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2-azino-bis-(3-ethylbenzthiazoline-6-sulphonic acid) (ABTS) radical cation methods...
May 8, 2017: Journal of Helminthology
https://www.readbyqxmd.com/read/28480391/anthelmintic-effects-of-dried-ground-banana-plant-leaves-musa-spp-fed-to-sheep-artificially-infected-with-haemonchus-contortus-and-trichostrongylus-colubriformis
#16
Lilian Gregory, Eidi Yoshihara, Leandro Kataoaka Fernandes Silva, Eduardo Carvalho Marques, Bruno Leonardo Mendonça Ribeiro, Enoch Brandão de Souza Meira, Rodolfo Santos Rossi, Alessandro Francisco Talamini do Amarante, Marjorie Yumi Hasegawa
BACKGROUND: Helminths is a endoparasites that cause the major losses for profitable sheep production in Brazil. The increased development of resistant strains of endoparasites have enforced the search for sustainable alternatives. The aim of this paper was to provide information about endoparasites control with banana leaves in infected sheep as alternative control strategies and see its viability. MATERIALS AND METHODS: In this study, we performed two trials to investigate the anthelmintic properties of banana leaves on endoparasites in sheep...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28456693/in%C3%A2-vitro-predatory-activity-of-arthrobotrys-oligospora-and-after-passing-through-gastrointestinal-tract-of-small-ruminants-on-infective-larvae-of-trichostrongylides
#17
Kui-Zheng Cai, Feng-Hui Wang, Kang-Ying Wang, Jun-Lin Liu, Bo-Bo Wang, Qiang Xu, Yu-Jia Xue, Fan Wang, Chao Zhang, Wen-Xiu Fang, Bin Cai, Yan-Qiu Liu, Xin Cao, Zhong-Ren Ma
In vitro predatory activity of 157 native isolates of Arthrobotrys oligospora from China on larvae of trichostrongylides (Trichostrongylus colubriformis and Haemonchus contortus) in feces of sheep were assessed. The results showed that 135 of tested isolates of A. oligospora reduced the development of trichostrongylide larvae in feces by 90-99.99%, 11 isolates by 80-89.46% and 11 isolates by 14.58-78.82%. To understand their capacity of passing through gastrointestinal tract of sheep, 50 native isolates of A...
June 2017: Experimental Parasitology
https://www.readbyqxmd.com/read/28456691/a-new-thioredoxin-reductase-with-additional-glutathione-reductase-activity-in-haemonchus-contortus
#18
Agustín Plancarte, Gabriela Nava, Javier A Munguía
We report, herein, the purification to homogeneity and the biochemical and kinetic characterization of HcTrxR3, a new isoform of thioredoxin reductase (TrxR) from Haemonchus contortus. HcTrxR3 was found to have a relative molecular weight of 134,000, while the corresponding value per subunit obtained under denaturing conditions, was of 67,000. By peptide mass spectrophotometric analysis, HcTrxR3 was determined to have 99% identity with the H. contortus HcTrxR1 although, and most importantly, they are different in their amino acid sequence in two amino acid positions: 48 (isoleucine instead of leucine) and 460 (leucine instead of proline)...
June 2017: Experimental Parasitology
https://www.readbyqxmd.com/read/28438225/meta-analysis-of-the-parasitic-phase-traits-of-haemonchus-contortus-infection-in-sheep
#19
Mathilde Saccareau, Guillaume Sallé, Christèle Robert-Granié, Tom Duchemin, Philippe Jacquiet, Alexandra Blanchard, Jacques Cabaret, Carole R Moreno
BACKGROUND: The parasitic nematode Haemonchus contortus shows highly variable life history traits. This highlights the need to have an average estimate and a quantification of the variation around it to calibrate epidemiological models. METHODS: This paper aimed to quantify the main life history traits of H. contortus and to identify explanatory factors affecting these traits using a powerful method based on a systematic review and meta-analysis of current literature...
April 24, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28438033/effects-of-polyphenol-removal-methods-on-the-in-vitro-exsheathment-inhibitory-activity-of-lysiloma-latisiliquum-extracts-against-haemonchus-contortus-larvae
#20
Gloria Ivonne Hernández-Bolio, Karlina García-Sosa, Fabiola Escalante-Erosa, Gloria Sarahi Castañeda-Ramírez, Enrique Sauri-Duch, Juan Felipe de Jesús Torres-Acosta, Luis Manuel Peña-Rodríguez
It has been suggested that the anthelmintic (AH) activity of tannin-rich forages is related to their tannin content. However, reports on tropical fodders such as Lysiloma latisiliquum describe the same AH activity after the addition of tannin-blocking agents, suggesting that the activity either depends on the method of tannin blocking/removal or is due to other type of secondary metabolites. This study compared both the effect of the drying process of the plant material and the effect of different polyphenol removal methods on the AH activity of L...
April 24, 2017: Natural Product Research
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