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haemonchus contortus

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https://www.readbyqxmd.com/read/28501715/mutations-in-the-hco-mptl-1-gene-in-a-field-derived-monepantel-resistant-isolate-of-haemonchus-contortus
#1
Neil H Bagnall, Angela Ruffell, Ali Raza, Timothy P Elliott, Jane Lamb, Peter W Hunt, Andrew C Kotze
Resistance to the anthelmintic drug monepantel (Zolvix(®)) has emerged in parasitic worms infecting sheep and goats. The mechanism of resistance in these cases is unknown. The drug targets nicotinic acetylcholine receptors belonging to the nematode-specific DEG-3 subfamily. We examined the receptor gene, Hco-mptl-1, in a highly Zolvix(®)-resistant and a -susceptible isolate of the parasitic nematode Haemonchus contortus. cDNA coding for the full length receptor protein (Hco-MPTL-1) was present in all clones prepared from a pool of susceptible larvae (21/21 clones) and approximately 50% of those from the resistant isolate (17/33)...
May 4, 2017: International Journal for Parasitology, Drugs and Drug Resistance
https://www.readbyqxmd.com/read/28495198/phenotypic-expression-of-parasite-susceptibility-to-haemonchus-contortus-in-pelibuey-sheep
#2
N F Ojeda-Robertos, J F J Torres-Acosta, R González-Garduño, D R Notter
The objective of this study was to determine if the mean faecal egg count (FEC) from a first experimental Haemonchus contortus infection could be used to classify parasite-naïve Pelibuey hair sheep as parasite-resistant high responders and parasite-susceptible low responders. Twenty 6- to 7-month-old Pelibuey male sheep raised free of gastrointestinal nematodes were challenged with 7500±1412 H. contortus L3 larvae administrated orally on day 0 of the study. Faecal samples from each lamb were obtained daily from 21 to 41days post-infection (Stage I)...
May 30, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28495192/effect-of-creep-fed-supplement-on-the-susceptibility-of-pasture-grazed-suckling-lambs-to-gastrointestinal-helminths
#3
Gleice Kelli Ayardes de Melo, Camila Celeste Brandão Ferreira Ítavo, Kedma Leonora Silva Monteiro, Jonilson Araújo da Silva, Pâmila Carolini Gonçalves da Silva, Luís Carlos Vinhas Ítavo, Dyego Gonçalves Lino Borges, Fernando de Almeida Borges
This study evaluated the effect of creep feeding a protein supplement on the susceptibility of suckling lambs to infection with gastrointestinal helminths. Male and female lambs were grazed on Brachiaria spp. pastures next to their mothers. Animals were allocated to one of two treatments: creep feeding (261g/d) and control (no supplementation). The trial period was the suckling of lambs during two years of study: May-October 2013 and March-July 2014. Supplementary creep feeding of lambs improved animal performance (P<0...
May 30, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28484087/modulation-of-goat-monocyte-function-by-hccyst-2-a-secreted-cystatin-from-haemonchus-contortus
#4
Yujian Wang, Yuling Wen, Shuai Wang, Muhammad Ehsan, RuoFeng Yan, XiaoKai Song, LiXin Xu, XiangRui Li
Modulation and suppression of the host immune response by nematode parasites have been reported extensively and the cysteine protease inhibitor (cystatin) is identified as one of the major immunomodulator. In the present study, we cloned and produced recombinant cystatin protein from nematode parasite Haemonchus contortus (rHCcyst-2) and investigated its immunomodulatory effects on goat monocyte. rHCcyst-2 protein is biologically functional as shown by its ability to inhibit the protease activity of cathepsin L, cathepsin B and papain...
April 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/28480837/anthelmintic-activity-of-tunisian-chamomile-matricaria-recutita-l-against-haemonchus-contortus
#5
S Hajaji, D Alimi, M A Jabri, S Abuseir, M Gharbi, H Akkari
The chemical treatment of gastrointestinal parasitic diseases has been undermined by increasing resistance and high toxicity. There is an urgent need to search for alternative natural sources for the treatment of such parasites. In this respect, the present study aims to quantify phenolic compounds of chamomile (Matricaria recutita L.) and to study their in vitro anti-oxidant and anthelmintic activities in solvents with increasing polarity. In vitro determination of anti-oxidant capacity was carried out using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2-azino-bis-(3-ethylbenzthiazoline-6-sulphonic acid) (ABTS) radical cation methods...
May 8, 2017: Journal of Helminthology
https://www.readbyqxmd.com/read/28480391/anthelmintic-effects-of-dried-ground-banana-plant-leaves-musa-spp-fed-to-sheep-artificially-infected-with-haemonchus-contortus-and-trichostrongylus-colubriformis
#6
Lilian Gregory, Eidi Yoshihara, Leandro Kataoaka Fernandes Silva, Eduardo Carvalho Marques, Bruno Leonardo Mendonça Ribeiro, Enoch Brandão de Souza Meira, Rodolfo Santos Rossi, Alessandro Francisco Talamini do Amarante, Marjorie Yumi Hasegawa
BACKGROUND: Helminths is a endoparasites that cause the major losses for profitable sheep production in Brazil. The increased development of resistant strains of endoparasites have enforced the search for sustainable alternatives. The aim of this paper was to provide information about endoparasites control with banana leaves in infected sheep as alternative control strategies and see its viability. MATERIALS AND METHODS: In this study, we performed two trials to investigate the anthelmintic properties of banana leaves on endoparasites in sheep...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28456693/in%C3%A2-vitro-predatory-activity-of-arthrobotrys-oligospora-and-after-passing-through-gastrointestinal-tract-of-small-ruminants-on-infective-larvae-of-trichostrongylides
#7
Kui-Zheng Cai, Feng-Hui Wang, Bo-Bo Wang, Jun-Lin Liu, Kang-Ying Wang, Qiang Xu, Yu-Jia Xue, Fan Wang, Chao Zhang, Wen-Xiu Fang, Bin Cai, Yan-Qiu Liu, Xin Cao, Zhong-Ren Ma
In vitro predatory activity of 157 native isolates of Arthrobotrys oligospora from China on larvae of trichostrongylides (Trichostrongylus colubriformis and Haemonchus contortus) in feces of sheep were assessed. The results showed that 135 of tested isolates of A. oligospora reduced the development of trichostrongylide larvae in feces by 90-99.99%, 11 isolates by 80-89.46% and 11 isolates by 14.58-78.82%. To understand their capacity of passing through gastrointestinal tract of sheep, 50 native isolates of A...
April 26, 2017: Experimental Parasitology
https://www.readbyqxmd.com/read/28456691/a-new-thioredoxin-reductase-with-additional-glutathione-reductase-activity-in-haemonchus-contortus
#8
Agustín Plancarte, Gabriela Nava, Javier A Munguía
We report, herein, the purification to homogeneity and the biochemical and kinetic characterization of HcTrxR3, a new isoform of thioredoxin reductase (TrxR) from Haemonchus contortus. HcTrxR3 was found to have a relative molecular weight of 134,000, while the corresponding value per subunit obtained under denaturing conditions, was of 67,000. By peptide mass spectrophotometric analysis, HcTrxR3 was determined to have 99% identity with the H. contortus HcTrxR1 although, and most importantly, they are different in their amino acid sequence in two amino acid positions: 48 (isoleucine instead of leucine) and 460 (leucine instead of proline)...
April 26, 2017: Experimental Parasitology
https://www.readbyqxmd.com/read/28438225/meta-analysis-of-the-parasitic-phase-traits-of-haemonchus-contortus-infection-in-sheep
#9
Mathilde Saccareau, Guillaume Sallé, Christèle Robert-Granié, Tom Duchemin, Philippe Jacquiet, Alexandra Blanchard, Jacques Cabaret, Carole R Moreno
BACKGROUND: The parasitic nematode Haemonchus contortus shows highly variable life history traits. This highlights the need to have an average estimate and a quantification of the variation around it to calibrate epidemiological models. METHODS: This paper aimed to quantify the main life history traits of H. contortus and to identify explanatory factors affecting these traits using a powerful method based on a systematic review and meta-analysis of current literature...
April 24, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28438033/effects-of-polyphenol-removal-methods-on-the-in-vitro-exsheathment-inhibitory-activity-of-lysiloma-latisiliquum-extracts-against-haemonchus-contortus-larvae
#10
Gloria Ivonne Hernández-Bolio, Karlina García-Sosa, Fabiola Escalante-Erosa, Gloria Sarahi Castañeda-Ramírez, Enrique Sauri-Duch, Juan Felipe de Jesús Torres-Acosta, Luis Manuel Peña-Rodríguez
It has been suggested that the anthelmintic (AH) activity of tannin-rich forages is related to their tannin content. However, reports on tropical fodders such as Lysiloma latisiliquum describe the same AH activity after the addition of tannin-blocking agents, suggesting that the activity either depends on the method of tannin blocking/removal or is due to other type of secondary metabolites. This study compared both the effect of the drying process of the plant material and the effect of different polyphenol removal methods on the AH activity of L...
April 24, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28420411/characterization-of-a-novel-aspartyl-protease-inhibitor-from-haemonchus-contortus
#11
Baojie Li, Javaid Ali Gadahi, Wenxiang Gao, Zhenchao Zhang, Muhammad Ehsan, Lixin Xu, Xiaokai Song, Xiangrui Li, Ruofeng Yan
BACKGROUND: Aspartyl protease inhibitor (API) was thought to protect intestinal parasitic nematodes from their hostile proteolytic environment. Studies on Ostertagia ostertagi, Ascaris suum and Brugia malayi indicated that aspins might play roles in nematode infection. In a recent study, proteins differentially expressed between free-living third-stage larvae (L3) and activated L3 (xL3) of Haemonchus contortus were identified by 2D-DIGE. API was found downregulated in xL3 when compared with L3...
April 19, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28414046/caffeoyl-and-coumaroyl-derivatives-from-acacia-cochliacantha-exhibit-ovicidal-activity-against-haemonchus-contortus
#12
G F Castillo-Mitre, A Olmedo-Juárez, R Rojo-Rubio, M Cortázar-González, P Mendoza-de Gives, E E Hernández-Beteta, D E Reyes-Guerrero, M E López-Arellano, J F Vázquez-Armijo, G Ramírez-Vargas, A Zamilpa
Ethnopharmacology relevance: Acacia cochliacantha is a small tree whose foliage is traditionally used in Mexico for treatment of kidney pain, gastrointestinal illnesses and to kill intestinal parasites. In recent decades, the study of vegetal extracts has offered other possible alternatives for the control of Haemonchus contortus. Considering that this nematode affects dramatically the health and productivity of small ruminants, the aim of this study was to identify the anthelmintic compounds from A. cochliacantha hydro-alcoholic extract (HA-E) through an ovicidal test...
April 14, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28407808/nested-pcr-assay-for-detection-of-schistosoma-japonicum-infection-in-domestic-animals
#13
Xin Zhang, Chuan-Chuan He, Jin-Ming Liu, Hao Li, Ke Lu, Zhi-Qiang Fu, Chuan-Gang Zhu, Yi-Ping Liu, Lai-Bao Tong, De-Bao Zhou, Li Zha, Yang Hong, Ya-Mei Jin, Jiao-Jiao Lin
BACKGROUND: Schistosomiasis japonica is a common zoonosis. Domestic animals are the primary source of infection and play an important role in disease transmission. The prevalence and infectivity of this disease in domestic animals in China have significantly decreased and, for this reason, diagnostics with a higher sensitivity have become increasingly necessary. It was reported that polymerase chain reaction (PCR)-based methods could be used to detect schistosome infection in humans and animals and presented a high sensitivity and specificity...
April 13, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28402951/characterization-of-a-secreted-macrophage-migration-inhibitory-factor-homologue-of-the-parasitic-nematode-haemonchus-contortus-acting-at-the-parasite-host-cell-interface
#14
Yujian Wang, MingMin Lu, Shuai Wang, Muhammad Ehsan, RuoFeng Yan, XiaoKai Song, LiXin Xu, XiangRui Li
Modulation and suppression of the immune response of the host by nematode parasites have been reported extensively and the migration inhibitory factor (MIF) is identified as one of the major immunomodulator. In the present study, we cloned and produced recombinant MIF protein from the small ruminant's nematode parasite Haemonchus contortus (rHCMIF-1), and investigated its immunomodulatory effects on goat monocyte. Enzymatic assays indicated that rHCMIF-1 possessed tautomerase activity. Immunohistochemical test demonstrated that the native HCMIF-1 protein was predominantly localized at the body surface and internal surface of the worm's gut...
March 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28391070/can-haemonchus-placei-primary-infected-na%C3%A3-ve-lambs-withstand-haemonchus-contortus-infections
#15
Regina Celis Pereira Reiniger, Luciana Laitano Dias de Castro, Magda Vieira Benavides, Maria Elisabeth Aires Berne
An experiment was conducted with the objective of evaluating whether a 5000 L3 larvae Haemonchus placei primary infection, a less pathogenic parasite species for sheep, could attenuate highly pathogenic Haemonchus contortus infections in lambs. Thirty nine 6-month-old lambs were divided in three primary-infection groups: (HcPI) H. contortus-primary infected lambs, (HpPI) H. placei-primary infected lambs, and (CTRL) non-infected control lambs. Later, these same individuals, then aged 10-month old, were cross challenged with Haemonchus parasite species, creating four groups: HcPI challenged with H...
February 28, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28389861/in-vitro-larvicidal-effect-of-a-hydroalcoholic-extract-from-acacia-cochliacantha-leaf-against-ruminant-parasitic-nematodes
#16
Agustín Olmedo-Juárez, Rolando Rojo-Rubio, Alejandro Zamilpa, Pedro Mendoza de Gives, Javier Arece-García, María Eugenia López-Arellano, Elke von Son-de Fernex
The aim of this study was to evaluate the in vitro lethal effect of a hydroalcoholic extract (HAE) from Acacia cochliacantha leaf against three gastrointestinal nematodes species (Haemonchus contortus, H. placei and Cooperia punctata) of domestic ruminants. The HAE was assessed using five concentrations: 100, 125, 175, 150 and 200 mg/ml; 0.5% Ivermectin was used as a positive control and distilled water, as negative control. The data were normalized using the square root and analysed with a completely randomized design through ANOVA analysis using the general lineal model (GLM) of the SAS program...
April 8, 2017: Veterinary Research Communications
https://www.readbyqxmd.com/read/28345265/cytokine-and-antioxidant-gene-profiles-from-peripheral-blood-mononuclear-cells-of-pelibuey-lambs-after-haemonchus-contortus-infection
#17
Zaira Estrada-Reyes, Ma Eugenia López-Arellano, Felipe Torres-Acosta, Alberto López-Reyes, Alfredo Lagunas-Martínez, Pedro Mendoza-de-Gives, Roberto González-Garduño, Sara Olazarán-Jenkins, David Reyes-Guerrero, Gabriel Ramírez-Vargas
The expression profiles of cytokines and anti-oxidant genes were determined from an experimental infection with H. contortus in Pelibuey lambs. The infection was followed for 34 days (d) to determine the number of eggs per gram (epg) and the packed cell volume (PCV). Differential white cell counts and expression profile estimations of IL2, IL4, IL5, IL6, IL8, IL10, IL13, FCεR1A, GPX and SOD1 were determined at 0 h, 4 h, 2 d and 14 d post-infection (PI) in infected and control groups. Comparison of the fold-change between 0 and 4 h, 4 h and 2 d, and 2 and 14 d periods was performed...
March 27, 2017: Parasite Immunology
https://www.readbyqxmd.com/read/28316426/genotyping-of-benzimidazole-resistant-and-susceptible-isolates-of-haemonchus-contortus-from-sheep-by-allele-specific-pcr
#18
Karthik Mohanraj, Subhra Subhadra, Aravindan Kalyanasundaram, Manikkavasagan Ilangopathy, Muthusamy Raman
Extensive and indiscriminate use of the benzimidazole class of drugs has led to the onset of anthelmintic resistance. In tropical countries like India, Haemonchus contortus is the most pathogenic parasite infecting sheep and goats. The widespread presence of resistant helminths (especially H. contortus) threatens the livestock farming. The use of various drugs has led to single nucleotide polymorphism that causes specific amino acid substitutions in β-tubulin protein of H. contortus to confer resistance. This emphasizes the need for a survey on the present status of resistance in India...
March 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/28288755/anthelmintic-activity-of-plant-extracts-from-brazilian-savanna
#19
Andreia F Oliveira, Livio M Costa Junior, Aldilene S Lima, Carolina R Silva, Maria N S Ribeiro, José W C Mesquista, Cláudia Q Rocha, Marcelo M P Tangerina, Wagner Vilegas
Helminth infections represent a serious problem for the production of small ruminants that is currently aggravated by resistance to anthelmintic products and has induced a search for control alternatives, such as natural products. In this study, extracts of Turnera ulmifolia L. (leaves and roots), Parkia platycephala Benth. (leaves and seeds) and Dimorphandra gardneriana Tul. (leaves and bark), which have been cited in ethnoveterinary studies and selected naturally by goats in the cerrado (Brazilian savanna), were tested in vitro against Haemonchus contortus...
March 15, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28262394/the-in-vitro-anthelmintic-properties-of-browse-plant-species-against-haemonchus-contortus-is-determined-by-the-polyphenol-content-and-composition
#20
G Mengistu, H Hoste, M Karonen, J-P Salminen, W H Hendriks, W F Pellikaan
The aims of the present study were to (a) evaluate the anthelmintic activity of 10 East African browse plant extracts, (b) examine their role in inhibition of Haemonchus contortus larval exsheathment, (c) establish relationship between inhibition of larval exsheathment and browse plant extract polyphenol composition. Acetone/water (70/30%) extracts of air dried leaves of Acacia etbaica, Cadaba farinosa, Capparis tomentosa, Dichrostachys cinerea, Dodonaea angustifolia, Euclea racemosa, Maerua angolensis, Maytenus senegalensis, Rhus natalensis and Senna singueana were used...
December 31, 2016: Veterinary Parasitology
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