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Bronchiolitis obliterans

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https://www.readbyqxmd.com/read/29159901/severe-stevens-johnson-syndrome-toxic-epidermal-necrolysis-overlap-syndrome-beyond-skin-involvement
#1
Tiago Milheiro Silva, João Farela Neves, Ana Casimiro, Luís Varandas, Catarina Gouveia
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but serious dermatologic diseases with many potential multisystem complications. We describe the case of an 8-year-old girl who developed severe SJS/TEN overlap syndrome (25% of her body surface area was affected) complicated by pancreatitis and bronchiolitis obliterans. These rare complications emphasize the need for careful, intensive monitoring of possible complications and an interdisciplinary team approach to provide optimal treatment and follow-up...
November 21, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/29135627/quantitative-computed-tomography-metrics-from-the-transplanted-lung-can-predict-forced-expiratory-volume-in-the-first-second-after-lung-transplantation
#2
Eduardo J Mortani Barbosa, Haochang Shou, Scott Simpsom, James Gee, Nicholas Tustison, James C Lee
PURPOSE: Bronchiolitis obliterans syndrome after lung transplantation (LTx) manifests as a sustained decline in forced expiratory volume in the first second (FEV1). Quantitative computed tomography (QCT) metrics may predict FEV1 better than semiquantitative scores (SQSs), and the transplanted lung may provide better information than the native lung in unilateral LTx. MATERIALS AND METHODS: Paired inspiratory-expiratory CT scans and pulmonary function testing of 178 LTx patients were analyzed retrospectively...
November 13, 2017: Journal of Thoracic Imaging
https://www.readbyqxmd.com/read/29128013/bronchiolitis-obliterans-syndrome-and-other-late-pulmonary-complications-after-allogeneic-hematopoietic-stem-cell-transplantation
#3
REVIEW
Anne Bergeron, Guang-Shing Cheng
As more individuals survive their hematologic malignancies after allogeneic hematopoietic stem cell transplantation (HSCT), there is growing appreciation of the late organ complications of this curative procedure for malignant and nonmalignant hematologic disorders. Late noninfectious pulmonary complications encompass all aspects of the bronchopulmonary anatomy. There have been recent advances in the diagnostic recognition and management of bronchiolitis obliterans syndrome, which is recognized as a pulmonary manifestation of chronic graft-versus-host disease...
December 2017: Clinics in Chest Medicine
https://www.readbyqxmd.com/read/29124031/successful-lung-transplantation-in-a-patient-with-myasthenia-gravis
#4
Kangmin Kim, Hyun Joo Lee, Samina Park, Yoohwa Hwang, Young Whan Kim, Young Tae Kim
A 47-year-old man with myasthenia gravis (MG) was admitted for a lung transplant. He had bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation due to acute myeloid leukemia. MG developed after stem cell transplantation. Bilateral sequential lung transplantations and a total thymectomy were performed. The patient underwent right diaphragmatic plication simultaneously due to preoperatively diagnosed right diaphragmatic paralysis. A tracheostomy was performed and bilevel positive airway pressure (BiPAP) was applied on postoperative days 8 and 9, respectively...
October 2017: Korean Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29123150/lung-clearance-index-and-quantitative-computed-tomography-of-post-infectious-bronchiolitis-obliterans-in-infants
#5
Yoon Hee Kim, Hyun Joo Shin, In Suk Sol, Soo Yeon Kim, Jong Deok Kim, Haesung Yoon, Kyung Won Kim, Myung-Joon Kim, Mi-Jung Lee, Myung Hyun Sohn
Post-infectious bronchiolitis obliterans (BO) could be diagnosed via spirometry and chest computed tomography (CT); however, these tests are limited in infants. We aimed to evaluate the utility of lung clearance index (LCI) and air-trapping lung volume from chest CT in infants. This prospective study included 20 infants (mean age, 10.9 ± 6.3 months) diagnosed with post-infectious BO between 2009 and 2016. All subjects underwent multiple breath washout tests. For quantitative analysis of chest CT, the mean lung area attenuation value was used as an individual cutoff to determine the air-trapping lung volume...
November 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29110800/long-term-outcomes-and-management-of-lung-transplant-recipients
#6
REVIEW
Joseph Costa, Luke J Benvenuto, Joshua R Sonett
Lung transplantation is an established treatment for patients with end-stage lung disease. Improvements in immunosuppression and therapeutic management of infections have resulted in improved long-term survival and a decline in allograft rejection. Allograft rejection continues to be a serious complication following lung transplantation, thereby leading to acute graft failure and, subsequently, chronic lung allograft dysfunction (CLAD). Bronchiolitis obliterans syndrome (BOS), the most common phenotype of CLAD, is the leading cause of late mortality and morbidity in lung recipients, with 50% having developed BOS within 5 years of lung transplantation...
June 2017: Best Practice & Research. Clinical Anaesthesiology
https://www.readbyqxmd.com/read/29108516/clinical-outcomes-of-paramyxovirus-infections-in-lung-transplant-recipients-treated-with-oral-ribavirin-a-two-center-case-series
#7
Bryan Garcia, Nirmal Sharma, Kevin Johnson, Juan Salgado, Keith Wille
OBJECTIVES: Paramyxoviruses contribute to morbidity and mortality after lung transplant and are associated with bronchiolitis obliterans syndrome. Oral ribavirin has been used off-label for treatment of paramyxoviruses in immunosuppressed patients; however, data supporting its use for this purpose are lacking. MATERIALS AND METHODS: We conducted a retrospective review to evaluate clinical outcomes of lung transplant recipients infected with paramyxoviruses and received treatment with oral ribavirin at 2 tertiary referral centers...
October 31, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29048473/use-of-taurolidine-in-lung-transplantation-for-cystic-fibrosis-and-impact-on-bacterial-colonization
#8
Mohamed Zeriouh, Anton Sabashnikov, Nikhil P Patil, Bastian Schmack, Barlomiej Zych, Prashant N Mohite, Diana García Sáez, Achim Koch, Ashham Mansur, Simona Soresi, Alexander Weymann, Nandor Marczin, Thorsten Wahlers, Fabio De Robertis, André Rüdiger Simon, Aron-Frederik Popov
OBJECTIVES: The presence of bacterial colonization that causes chronic pulmonary infections in cystic fibrosis (CF) patients remains a key issue before lung transplantation. We sought to assess the impact of intraoperative taurolidine lavage on bacterial colonization and long-term outcomes following lung transplantation in CF patients. METHODS: Between 2007 and 2013, 114 CF patients underwent lung transplantation at our institute, and taurolidine 2% bronchial lavage was applied in a substantial proportion of patients (n = 42)...
October 18, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28988958/mycobacterium-abscessus-and-massiliense-lung-infection-during-macrolide-treatment-for-bronchiolitis-obliterans-after-allogeneic-hematopoietic-stem-cell-transplantation
#9
Noriko Miyake, Yong Chong, Ruriko Nishida, Katsuto Takenaka, Koji Kato, Toshihiro Miyamoto, Akio Aono, Akiko Takaki, Satoshi Mitarai, Shinji Shimoda, Nobuyuki Shimono, Koichi Akashi
In patients undergoing allogeneic hematopoietic stem cell transplantation (allo-SCT), post-transplant lung infection is critical for their prognosis. Mycobacterium abscessus complex is not fully recognized as a nontuberculous mycobacteria (NTM) pathogen of post-SCT lung infection. Here, we present three post-allogeneic SCT patients who developed pulmonary infection caused by M. abscessus complex including M. abscessus and M. massiliense. In all three cases, macrolide antibiotics had been administered for bronchiolitis obliterans syndrome (BOS) before the confirmation of their infection, and macrolide resistance was noted in the M...
October 5, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28959632/diacetyl-and-2-3-pentanedione-in-breathing-zone-and-area-air-during-large-scale-commercial-coffee-roasting-blending-and-grinding-processes
#10
Michael J McCoy, Kimberly A Hoppe Parr, Kim E Anderson, Jim Cornish, Matti Haapala, John Greivell
Recently described scientific literature has identified the airborne presence of 2,3-butanedione (diacetyl) and 2,3-pentanedione at concentrations approaching or potentially exceeding the current American Conference of Industrial Hygienists' (ACGIH) Threshold Limit Values (TLVs) at commercial coffee roasting and production facilities. Newly established National Institutes of Occupational Safety and Health (NIOSH) Recommended Exposure Limits for diacetyl and 2,3-pentanedione are even more conservative. Chronic exposure to these alpha-diketones at elevated airborne concentrations has been associated with lung damage, specifically bronchiolitis obliterans, most notably in industrial food processing facilities...
2017: Toxicology Reports
https://www.readbyqxmd.com/read/28956954/hiv-related-chronic-lung-disease-in-adolescents-are-we-prepared-for-the-future
#11
Pierre Goussard, Robert P Gie
Chronic lung diseases (CLD) are the most chronic disease occurring in adolescents living with human immunodeficiency virus (ALHIV). In ALHIV who received antiretroviral therapy (ART) late in childhood, bronchiectasis, bronchiolitis obliterans and interstitial pneumonitis are common. In adolescents who received ART early in life the spectrum of CLD has changed with asthma and chronic obstructive pulmonary disease being common. Areas covered: The aim of this paper was to review CLD in ALHIV. We conducted a literature review of electronic databases focusing on CLD that were common prior to the introduction of ART (1996-2004), the present situation where ART is widely available (2005 to 2016), and articles which aided us speculating on the impact of HIV-related CLD in adolescents transitioning to adult HIV-clinics...
December 2017: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/28932572/chronic-lung-allograft-dysfunction-phenotypes-and-treatment
#12
REVIEW
Stijn E Verleden, Robin Vos, Bart M Vanaudenaerde, Geert M Verleden
Chronic lung allograft dysfunction (CLAD) remains a major hurdle limiting long-term survival post lung transplantation. Given the clinical heterogeneity of CLAD, recently two phenotypes of CLAD have been defined [bronchiolitis obliterans syndrome (BOS) vs. restrictive allograft syndrome (RAS) or restrictive CLAD (rCLAD)]. BOS is characterized by an obstructive pulmonary function, air trapping on CT and obliterative bronchiolitis (OB) on histopathology, while RAS/rCLAD patients show a restrictive pulmonary function, persistent pleuro-parenchymal infiltrates on CT and pleuroparenchymal fibro-elastosis on biopsies...
August 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28932558/results-of-quantitative-chest-ct-in-chronic-pulmonary-graft-vs-host-disease-cgvhd-3-years-after-allogeneic-stem-cell-transplantation
#13
Christopher Kloth, Wolfgang M Thaiss, Jürgen Hetzel, Georg Bier, Stefan Wirths, Konstantin Nikolaou, Marius Horger
BACKGROUND: To quantify lung parenchymal changes in symptomatic patients with chronic pulmonary graft-versus-host disease 3 years after allogeneic stem cell transplantation (allo-SCT) by means of CT-densitometry (CTD) and to compare results with those of established pulmonary function tests (PFT). METHODS: The study group consisted of 26 patients with pulmonary cGvHD (19 males, 7 females; mean age, 49.29±15.89; range, 19-72 years). The diagnosis was based on clinical symptoms, PFT and chest-CT findings...
August 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28932229/association-between-a-single-donor-tarc-ccl17-promotor-polymorphism-and-obstructive-chronic-lung-allograft-dysfunction-after-lung-transplantation
#14
Kevin Budding, Jessica van Setten, Eduard A van de Graaf, Oliver A van Rossum, Tineke Kardol-Hoefnagel, Erik-Jan D Oudijk, C Erik Hack, Henderikus G Otten
Lung transplantation (LTx) outcome is hampered by development of chronic rejection, often manifested as the bronchiolitis obliterans syndrome (BOS). Low serum levels of thymus and activation-regulated chemokine (TARC/CCL17), a chemoattractant, measured during the first month post-LTx are predictive for BOS development. Since TARC/CCL17 promotor polymorphisms correlate with serum TARC/CCL17 levels, we investigated seven single-nucleotide polymorphisms (SNPs) within this region and their potential association with LTx outcome...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28926522/bos-is-associated-with-increased-cytotoxic-proinflammatory-cd8-t-nkt-like-and-nk-cells-in-the-small-airways
#15
Greg Hodge, Sandra Hodge, Aeneas Yeo, Phan Nguyen, Emily Hopkins, Chien-Li Holmes-Liew, Paul N Reynolds, Mark Holmes
BACKGROUND: Immunosuppression therapy after lung transplantation fails to prevent bronchiolitis obliterans syndrome (BOS) in many patients, primarily a disease of the small airways. We have reported that BOS is associated with a lack of suppression of cytotoxic mediators, and proinflammatory cytokines, in peripheral blood T, NKT-like (particularly CD8+) and NK cells. We also showed a loss of glucocorticoid receptor (GCR) in proinflammatory lymphocytes after transplant. It is unknown whether these proinflammatory lymphocytes target the small and/or large airways in BOS...
October 2017: Transplantation
https://www.readbyqxmd.com/read/28894914/effect-of-rituximab-on-pulmonary-function-in-bronchiolitis-obliterans-syndrome-due-to-graft-versus-host-disease
#16
Kyle R Brownback, Laura A Thomas, Joseph P McGuirk, Siddhartha Ganguly, Christopher Streiler, Sunil Abhyankar
PURPOSE: Rituximab is an anti-CD20 monoclonal antibody that is used to suppress B-cell function in graft-versus-host-disease (GVHD). We sought to determine the effects of rituximab treatment on lung function in those patients with bronchiolitis obliterans syndrome (BOS) as a manifestation of GVHD. METHODS: Thirteen patients were treated with rituximab with a diagnosis of BOS and a significant reduction in the forced expiratory volume in 1 s (FEV1) after hematopoietic stem cell transplantation (HSCT)...
December 2017: Lung
https://www.readbyqxmd.com/read/28886227/lung-transplantation-in-cystic-fibrosis-patients-in-israel-the-importance-of-ethnicity-and-nutritional-status
#17
Hagit Levine, Dario Prais, Yael Raviv, Victorya Rusanov, Dror Rosengarten, Milton Saute, Moshe Hoshen, Huda Mussaffi, Hannah Blau, Mordechai R Kramer
OBJECTIVES: To assess the characteristics that correlate with better outcomes after lung transplantation for patients with cystic fibrosis (CF). METHODS: We retrospectively reviewed the charts of all patients with CF who underwent lung transplantation between 1996-2014 at Rabin Medical Center, Israel. RESULTS: Fifty patients with CF underwent 55 lung transplantations. Eighteen patients (36%) died during the study period. Actuarial survival was 83%, 68%, 62% and 39% at 1, 3, 5 and 10 years, respectively...
September 8, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28877826/clinical-analysis-of-unicentric-castleman-s-disease-with-paraneoplastic-pemphigus-and-bronchiolitis-obliterans
#18
Jun-Feng Zhen, Lu Zhang, Xin-Xin Cao, Jun Feng, Dao-Bin Zhou, Song-Bai Lin, Jian Li
Objective To investigate the clinical features of unicentric Castleman's disease(UCD)with paraneoplastic pemphigus(PNP)and bronchiolitis obliterans(BO).Method Data of UCD patients with PNP and BO from Peking Union Medical College Hospital were retrospectively analyzed,along with literatures review. Results Totally 23 cases(11 males and 12 females)were enrolled.The median age was 31 years(13-56 years).The most common pathological type was hyaline-vascular variant(91.4%),and most tumors located in abdominopelvic cavity(69...
August 20, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/28871078/impact-of-forced-expiratory-volume-in-1-second-fev1-and-6-minute-walking-distance-at-3-6-and-12-months-and-annually-on-survival-and-occurrence-of-bronchiolitis-obliterans-syndrome-bos-after-lung-transplantation
#19
Mohammed Fakhro, Richard Ingemansson, Lars Algotsson, Sandra Lindstedt
BACKGROUND Development of bronchiolitis obliterans syndrome (BOS) is a great limitation for patient survival in lung transplantation (LTx). A curative treatment for BOS is still missing, and in terminal stages re-transplantation (Re-LTx) is the only salvation. It is possible to slow the progress of BOS if it is detected at an early stage. This might be possible by assessing pulmonary function pattern. MATERIAL AND METHODS Between 1990 and 2014, 278 patients underwent LTx at Skåne University Hospital, Sweden...
September 5, 2017: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/28823117/development-of-bronchiolitis-obliterans-organizing-pneumonia-during-standard-treatment-of-hepatitis-c-with-peg-ifn%C3%AE-2b
#20
Eun Chung, Kihoon Park, Jo Heon Kim, Nam Ik Han, Young Sok Lee, Si Hyun Bae, Chung-Hwa Park
No abstract text is available yet for this article.
November 2017: Korean Journal of Internal Medicine
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