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https://www.readbyqxmd.com/read/28334167/identification-of-genetic-outliers-due-to-sub-structure-and-cryptic-relationships
#1
Daniel Schlauch, Heide Fier, Christoph Lange
Motivation: In order to minimize the effects of genetic confounding on the analysis of high-throughput genetic association studies, e.g. (whole-genome) sequencing (WGS) studies, genome-wide association studies (GWAS), etc., we propose a general framework to assess and to test formally for genetic heterogeneity among study subjects. As the approach fully utilizes the recent ancestor information captured by rare variants, it is especially powerful in WGS studies. Even for relatively moderate sample sizes, the proposed testing framework is able to identify study subjects that are genetically too similar, e...
February 22, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28317049/programming-and-runtime-support-to-blaze-fpga-accelerator-deployment-at-datacenter-scale
#2
Muhuan Huang, Di Wu, Cody Hao Yu, Zhenman Fang, Matteo Interlandi, Tyson Condie, Jason Cong
With the end of CPU core scaling due to dark silicon limitations, customized accelerators on FPGAs have gained increased attention in modern datacenters due to their lower power, high performance and energy efficiency. Evidenced by Microsoft's FPGA deployment in its Bing search engine and Intel's 16.7 billion acquisition of Altera, integrating FPGAs into datacenters is considered one of the most promising approaches to sustain future datacenter growth. However, it is quite challenging for existing big data computing systems-like Apache Spark and Hadoop-to access the performance and energy benefits of FPGA accelerators...
October 2016: Proc ACM Symp Cloud Comput
https://www.readbyqxmd.com/read/28316594/power-and-time-dependent-microwave-assisted-fabrication-of-silver-nanoparticles-decorated-cotton-sndc-fibers-for-bacterial-decontamination
#3
Abhishek K Bhardwaj, Abhishek Shukla, Rohit K Mishra, S C Singh, Vani Mishra, K N Uttam, Mohan P Singh, Shivesh Sharma, R Gopal
Plasmonic nanoparticles (NPs) such as silver and gold have fascinating optical properties due to their enhanced optical sensitivity at a wavelength corresponding to their surface plasmon resonance (SPR) absorption. Present work deals with the fabrication of silver nanoparticles decorated cotton (SNDC) fibers as a cheap and efficient point of contact disinfectant. SNDC fibers were fabricated by a simple microwave assisted route. The microwave power and irradiation time were controlled to optimize size and density of silver nanoparticles (SNPs) on textile fibers...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28293828/pm2-5-emissions-from-different-types-of-heavy-duty-truck-a-case-study-and-meta-analysis-of-the-beijing-tianjin-hebei-region
#4
Liying Song, Hongqing Song, Jingyi Lin, Cheng Wang, Mingxu Yu, Xiaoxia Huang, Yu Guan, Xing Wang, Li Du
Beijing-Tianjin-Hebei (BTH) region in China is affected seriously by the hazy weather that has a large impact on human health. PM2.5 is one of the most important reasons for hazy weather. Understanding the PM2.5 emission characteristics from different types of heavy-duty trucks (HDTs) is valuable in policies and regulations to improve urban air quality and mitigate vehicle emission in China. The investigation and analysis on HDT population and PM2.5 emission in BTH region are carried out. The results show that the population and PM2...
March 14, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28285238/operation-of-passive-membrane-systems-for-drinking-water-treatment
#5
P A Oka, N Khadem, P R Bérubé
The widespread adoption of submerged hollow fibre ultrafiltration (UF) for drinking water treatment is currently hindered by the complexity and cost of these membrane systems, especially in small/remote communities. Most of the complexity is associated with auxiliary fouling control measures, which include backwashing, air sparging and chemical cleaning. Recent studies have demonstrated that sustained operation without fouling control measures is possible, but little is known regarding the conditions under which extended operation can be sustained with minimal to no fouling control measures...
February 28, 2017: Water Research
https://www.readbyqxmd.com/read/28284133/monitoring-and-source-apportionment-of-trace-elements-in-pm2-5-implications-for-local-air-quality-management
#6
Yueyan Li, Miao Chang, Shanshan Ding, Shiwen Wang, Dun Ni, Hongtao Hu
Fine particulate matter (PM2.5) samples were collected simultaneously every hour in Beijing between April 2014 and April 2015 at five sites. Thirteen trace elements (TEs) in PM2.5 were analyzed by online X-ray fluorescence (XRF). The annual average PM2.5 concentrations ranged from 76.8 to 102.7 μg m(-3). TEs accounted for 5.9%-8.7% of the total PM2.5 mass with Cl, S, K, and Si as the most dominant elements. Spearman correlation coefficients of PM2.5 or TE concentrations between the background site and other sites showed that PM2...
March 8, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28269079/evaluation-of-the-low-frequency-components-in-surface-electromyography
#7
Agnese Sbrollini, Angela Agostinelli, Francesco Di Nardo, Elvira Maranesi, Alessandro Mengarelli, Sandro Fioretti, Laura Burattini
The surface electromyogram (SEMG) is a signal noninvasively (through electrodes located on the body surface) acquired for evaluating the electrical activity produced by skeletal muscles. In thoracic acquisitions, SEMG is typically affected by the electrocardiographic (ECG) signal, representing the electrical activity of the heart. SEMG and ECG power spectra mainly fall within 5-450 Hz and 0.05-50 Hz, respectively. Consequently, SEMG and ECG components overlap in the 5-50 Hz range. Although removing SEMG low spectral components, high-pass linear filtering (LF) with a cut-off frequency of 20 Hz remains the standard technique to clean SEMG from ECG...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268483/improving-test-retest-reliability-of-quantitative-electroencephalography-using-different-preprocessing-approaches
#8
Jazmin Suarez-Revelo, John Ochoa-Gomez, Jon Duque-Grajales
This work aims to assess the effect of preprocessing approaches over test-retest reliability of quantitative electroencephalography measurements. Two electroencephalography sessions were recorded during an eyes-closed resting state condition in 15 young healthy individuals. The second session was 4 to 6 weeks after the first one. Clean recordings were obtained from the implementation of different preprocessing approaches commonly used in the literature. We then estimated the power spectrum density, for each individual and preprocessing approach, in six frequency bands: delta, theta, alpha1, alpha2, beta, and gamma...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28251692/all-weather-solar-cells-a-rising-photovoltaic-revolutionary
#9
Qunwei Tang
Solar cells have been considered as one of the foremost solutions to energy and environmental problems because of clean, high efficiency, cost-effective and inexhaustible features. The historical development and state-of-the-art solar cells are mainly focusing on elevating photoelectric conversion efficiency upon direct sunlight illumination. It is still a challenging problem to realize persistent high-efficiency power generation in rainy, foggy, haze and night etc dark-light conditions. The physical proof-of-concept for all-weather solar cells opens a door for upcoming photovoltaic revolutions...
March 1, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28248344/second-harmonic-generation-in-multimode-graded-index-fibers-spatial-beam-cleaning-and-multiple-harmonic-sideband-generation
#10
D Ceoldo, K Krupa, A Tonello, V Couderc, D Modotto, U Minoni, G Millot, S Wabnitz
We study experimentally and numerically the spectral and spatial dynamics of second harmonic generation in an all-optically poled multimode graded-index fiber. In contrast with poled single-mode fibers, in a multimode graded-index fiber a pump can generate a series of sharp sidebands around its second harmonic (SH) that originate from the sub-millimetric periodic evolution of the intensity at the fundamental frequency. The mutual interaction between the fundamental and its SH may also strongly affect the spatial distribution of guided light for both colors: when increasing the pump power, both fundamental and SH output beams evolve from disordered multimode speckles into two bell-shaped beams...
March 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/28239761/microalgal-hydrogen-production-prospects-of-an-essential-technology-for-a-clean-and-sustainable-energy-economy
#11
REVIEW
Vinzenz Bayro-Kaiser, Nathan Nelson
Modern energy production is required to undergo a dramatic transformation. It will have to replace fossil fuel use by a sustainable and clean energy economy while meeting the growing world energy needs. This review analyzes the current energy sector, available energy sources, and energy conversion technologies. Solar energy is the only energy source with the potential to fully replace fossil fuels, and hydrogen is a crucial energy carrier for ensuring energy availability across the globe. The importance of photosynthetic hydrogen production for a solar-powered hydrogen economy is highlighted and the development and potential of this technology are discussed...
February 26, 2017: Photosynthesis Research
https://www.readbyqxmd.com/read/28238364/design-and-performance-of-subgrade-biogeochemical-reactors
#12
Jeff Gamlin, Doug Downey, Brad Shearer, Paul Favara
Subgrade biogeochemical reactors (SBGRs), also commonly referred to as in situ bioreactors, are a unique technology for treatment of contaminant source areas and groundwater plume hot spots. SBGRs have most commonly been configured for enhanced reductive dechlorination (ERD) applications for chlorinated solvent treatment. However, they have also been designed for other contaminant classes using alternative treatment media. The SBGR technology typically consists of removal of contaminated soil via excavation or large-diameter augers, and backfill of the soil void with gravel and treatment amendments tailored to the target contaminant(s)...
February 18, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28227299/evaluation-of-the-low-frequency-components-in-surface-electromyography
#13
Agnese Sbrollini, Angela Agostinelli, Francesco Di Nardo, Elvira Maranesi, Alessandro Mengarelli, Sandro Fioretti, Laura Burattini, Agnese Sbrollini, Angela Agostinelli, Francesco Di Nardo, Elvira Maranesi, Alessandro Mengarelli, Sandro Fioretti, Laura Burattini, Francesco Di Nardo, Sandro Fioretti, Agnese Sbrollini, Elvira Maranesi, Laura Burattini, Angela Agostinelli, Alessandro Mengarelli
The surface electromyogram (SEMG) is a signal noninvasively (through electrodes located on the body surface) acquired for evaluating the electrical activity produced by skeletal muscles. In thoracic acquisitions, SEMG is typically affected by the electrocardiographic (ECG) signal, representing the electrical activity of the heart. SEMG and ECG power spectra mainly fall within 5-450 Hz and 0.05-50 Hz, respectively. Consequently, SEMG and ECG components overlap in the 5-50 Hz range. Although removing SEMG low spectral components, high-pass linear filtering (LF) with a cut-off frequency of 20 Hz remains the standard technique to clean SEMG from ECG...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226657/improving-test-retest-reliability-of-quantitative-electroencephalography-using-different-preprocessing-approaches
#14
Jazmin Suarez-Revelo, John Ochoa-Gomez, Jon Duque-Grajales, Jazmin Suarez-Revelo, John Ochoa-Gomez, Jon Duque-Grajales, Jon Duque-Grajales, John Ochoa-Gomez, Jazmin Suarez-Revelo
This work aims to assess the effect of preprocessing approaches over test-retest reliability of quantitative electroencephalography measurements. Two electroencephalography sessions were recorded during an eyes-closed resting state condition in 15 young healthy individuals. The second session was 4 to 6 weeks after the first one. Clean recordings were obtained from the implementation of different preprocessing approaches commonly used in the literature. We then estimated the power spectrum density, for each individual and preprocessing approach, in six frequency bands: delta, theta, alpha1, alpha2, beta, and gamma...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28222156/toothbrush-abrasivity-in-a-long-term-simulation-on-human-dentin-depends-on-brushing-mode-and-bristle-arrangement
#15
Mozhgan Bizhang, Ilka Schmidt, Yong-Hee Patricia Chun, Wolfgang H Arnold, Stefan Zimmer
OBJECTIVE: The aim of this study was to evaluate the susceptibility of dentin to brushing abrasion using four different toothbrushes (rotating-oscillating, sonic and two types of manual toothbrushes) with the same brushing forces. METHODS: Dentin samples (n = 72) were selected from 72 impacted third molars. Half of the surface of dentin samples was covered with an adhesive tape, creating a protected and a freely exposed area in the same specimen. Brushing was performed with either a: sonic (Sonicare PowerUp, Philips GmbH, Hamburg, Germany), b: oscillating-rotating (Oral B Vitality Precisions Clean, Procter & Gamble, Schwalbach am Taunus, Germany) or two different manual toothbrushes c: flat trim brush head toothbrush (Dr...
2017: PloS One
https://www.readbyqxmd.com/read/28208621/a-framework-for-bus-trajectory-extraction-and-missing-data-recovery-for-data-sampled-from-the-internet
#16
Changfei Tong, Huiling Chen, Qi Xuan, Xuhua Yang
This paper presents a novel framework for trajectories' extraction and missing data recovery for bus traveling data sampled from the Internet. The trajectory extraction procedure is composed of three main parts: trajectory clustering, trajectory cleaning and trajectory connecting. In the clustering procedure, we focus on feature construction and parameter selection for the fuzzy C-means clustering method. Following the clustering procedure, the trajectory cleaning algorithm is implemented based on a new introduced fuzzy connecting matrix, which evaluates the possibility of data belonging to the same trajectory and helps detect the anomalies in a ranked context-related order...
February 10, 2017: Sensors
https://www.readbyqxmd.com/read/28195976/self-reported-measures-of-strength-and-sport-specific-skills-distinguish-ranking-in-an-international-online-fitness-competition
#17
Paul R Serafini, Yuri Feito, Gerald T Mangine
To determine if self-reported performance measures could distinguish ranking during the 2016 CrossFit Open, data from three thousand male (n=1500; 27.2±8.4 y; 85.2±7.9 kg; 177.0±6.5 cm) and female (n=1500, 28.7±4.9 y; 63.7±5.8 kg; 163.7±6.6 cm) competitors was used for this study. Competitors were split by gender and grouped into quintiles (Q1-Q5) based upon their final ranking. Quintiles were compared for one-repetition maximum (1RM) squat, deadlift, clean and jerk (CJ), snatch, 400-m sprint, 5,000-m run, and benchmark workouts (Fran, Helen, Grace, Filthy-50, and Fight-gone-bad)...
February 8, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28192439/regenotyper-detecting-mislabeled-samples-in-genetic-data
#18
Konrad Zych, Basten L Snoek, Mark Elvin, Miriam Rodriguez, K Joeri Van der Velde, Danny Arends, Harm-Jan Westra, Morris A Swertz, Gino Poulin, Jan E Kammenga, Rainer Breitling, Ritsert C Jansen, Yang Li
In high-throughput molecular profiling studies, genotype labels can be wrongly assigned at various experimental steps; the resulting mislabeled samples seriously reduce the power to detect the genetic basis of phenotypic variation. We have developed an approach to detect potential mislabeling, recover the "ideal" genotype and identify "best-matched" labels for mislabeled samples. On average, we identified 4% of samples as mislabeled in eight published datasets, highlighting the necessity of applying a "data cleaning" step before standard data analysis...
2017: PloS One
https://www.readbyqxmd.com/read/28187777/gmp-conformant-on-site-manufacturing-of-a-cd133-stem-cell-product-for-cardiovascular-regeneration
#19
Anna Skorska, Paula Müller, Ralf Gaebel, Jana Große, Heiko Lemcke, Cornelia A Lux, Manuela Bastian, Frauke Hausburg, Nicole Zarniko, Sandra Bubritzki, Ulrike Ruch, Gudrun Tiedemann, Robert David, Gustav Steinhoff
BACKGROUND: CD133(+) stem cells represent a promising subpopulation for innovative cell-based therapies in cardiovascular regeneration. Several clinical trials have shown remarkable beneficial effects following their intramyocardial transplantation. Yet, the purification of CD133(+) stem cells is typically performed in centralized clean room facilities using semi-automatic manufacturing processes based on magnetic cell sorting (MACS®). However, this requires time-consuming and cost-intensive logistics...
February 10, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28167769/multifunctional-inexpensive-and-reusable-nanoparticle-printed-biochip-for-cell-manipulation-and-diagnosis
#20
Rahim Esfandyarpour, Matthew J DiDonato, Yuxin Yang, Naside Gozde Durmus, James S Harris, Ronald W Davis
Isolation and characterization of rare cells and molecules from a heterogeneous population is of critical importance in diagnosis of common lethal diseases such as malaria, tuberculosis, HIV, and cancer. For the developing world, point-of-care (POC) diagnostics design must account for limited funds, modest public health infrastructure, and low power availability. To address these challenges, here we integrate microfluidics, electronics, and inkjet printing to build an ultra-low-cost, rapid, and miniaturized lab-on-a-chip (LOC) platform...
February 21, 2017: Proceedings of the National Academy of Sciences of the United States of America
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