keyword
https://read.qxmd.com/read/38537086/effect-of-dexmedetomidine-on-the-incidence-of-postoperative-acute-kidney-injury-in-living-donor-liver-transplantation-recipients-a-randomized-controlled-trial
#1
JOURNAL ARTICLE
Hye-Mee Kwon, Sa-Jin Kang, Sang-Bin Han, Jae Hwan Kim, Sung-Hoon Kim, In-Gu Jun, Jun-Gol Song, Gyu-Sam Hwang
BACKGROUND: Acute kidney injury (AKI) is one of the most common complications after living-donor liver transplantation (LDLT) that has great impact on recipient and graft outcomes. Dexmedetomidine is reported to decrease the incidence of AKI. In the current study, we investigated whether intraoperative dexmedetomidine infusion would reduce the AKI following LDLT. MATERIAL AND METHODS: In total, 205 adult patients undergoing elective LDLT were randomly assigned to the dexmedetomidine group (n=103) or the control group (n=102)...
April 3, 2024: International Journal of Surgery
https://read.qxmd.com/read/38532434/optimization-of-cardiopulmonary-bypass-prime-fluid-to-preserve-microcirculatory-perfusion-during-on-pump-coronary-artery-bypass-graft-surgery-prime-study-protocol-for-a-double-blind-randomized-trial
#2
JOURNAL ARTICLE
Anne M Beukers, Carolien S E Bulte, Ruben J Bosch, Susanne Eberl, Charissa E van den Brom, Stephan A Loer, Alexander B A Vonk
BACKGROUND: Acute microcirculatory perfusion disturbances and organ edema are important factors leading to organ dysfunction during cardiac surgery with cardiopulmonary bypass (CPB). Priming of the CPB system with crystalloid or colloid fluids, which inevitably leads to hemodilution, could contribute to this effect. However, there is yet no optimal evidence-based strategy for this type of priming. Hence, we will investigate different priming strategies to reduce hemodilution and preserve microcirculatory perfusion...
March 26, 2024: Trials
https://read.qxmd.com/read/38514014/myeloid-derived-suppressor-cells-promote-allograft-survival-by-suppressing-treg-dysfunction-in-high-risk-corneal-transplantation
#3
JOURNAL ARTICLE
Seokjoo Lee, Tomas Blanco, Aytan Musayeva, Shima Dehghani Ahmadabad, Akitomo Narimatsu, Katayoon Forouzanfar, Gustavo Ortiz, Francesca Kahale, Shudan Wang, Yihe Chen, Thomas H Dohlman, Sunil K Chauhan, Reza Dana
Highly inflamed and neovascularized corneal graft beds are known as high-risk environments for transplant survival. One of the primary factors leading to this rejection is reduction in the suppressive function of regulatory T cells (Treg). Our results show that myeloid-derived suppressor cells (MDSC) counteract IL-6-mediated Treg dysfunction by expressing IL-10. Additionally, MDSC maintain FoxP3 stability and their ability to suppress IFN-γ+ Th1 cells. Administering MDSC to high-risk corneal transplant recipients demonstrates prolonged graft survival via promotion of Treg while concurrently suppressing IFN-γ+ Th1 cells...
March 19, 2024: American Journal of Transplantation
https://read.qxmd.com/read/38513917/applications-of-transcriptomics-in-ischemia-reperfusion-research-in-lung-transplantation
#4
REVIEW
Jamie E Jeon, Yasal Rajapaksa, Shaf Keshavjee, Mingyao Liu
Ischemia-reperfusion (IR) injury contributes to primary graft dysfunction, a major cause of early mortality after lung transplantation. Transcriptomics uses high-throughput techniques to profile the RNA transcripts within a sample and provides a unique view of the mechanisms underlying various biological processes. This review aims to highlight the applications of transcriptomics in lung IR injury studies, which have thus far revealed inflammatory responses to be the major event activated by IR, identified potential biomarkers and therapeutic targets, and investigated the mechanisms of therapeutic interventions...
March 19, 2024: Journal of Heart and Lung Transplantation
https://read.qxmd.com/read/38510260/the-impact-and-relevance-of-techniques-and-fluids-on-lung-injury-in-machine-perfusion-of-lungs
#5
REVIEW
Florian Ponholzer, Julia Dumfarth, Christoph Krapf, Andreas Pircher, Theresa Hautz, Dominik Wolf, Florian Augustin, Stefan Schneeberger
Primary graft dysfunction (PGD) is a common complication after lung transplantation. A plethora of contributing factors are known and assessment of donor lung function prior to organ retrieval is mandatory for determination of lung quality. Specialized centers increasingly perform ex vivo lung perfusion (EVLP) to further assess lung functionality and improve and extend lung preservation with the aim to increase lung utilization. EVLP can be performed following different protocols. The impact of the individual EVLP parameters on PGD development, organ function and postoperative outcome remains to be fully investigated...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38508486/ex-vivo-lung-perfusion-in-donation-after-circulatory-death-a-post-hoc-analysis-of-the-novel-trial
#6
JOURNAL ARTICLE
Doug A Gouchoe, Pablo G Sanchez, Jonathan D'Cunha, Christian A Bermudez, Mani A Daneshmand, Robert D Davis, Matthew G Hartwig, Thomas C Wozniak, Zachary N Kon, Bartley P Griffith, William R Lynch, Tiago N Machuca, Michael J Weyant, Michael E Jessen, Michael S Mulligan, Frank D'Ovidio, Phillip C Camp, Edward Cantu, Bryan A Whitson
OBJECTIVE: Donation after circulatory death (DCD) donors offer the ability to expand the lung donor pool and ex vivo lung perfusion (EVLP) further contributes to this ability by allowing for additional evaluation and resuscitation of these extended criteria donors. We sought to determine the outcomes of recipients receiving organs from DCD EVLP donors in a multi-center setting. METHODS: This was an unplanned post-hoc analysis of a multicenter, prospective, non-randomized trial that took place in 2011-2017 with 3-years of follow up...
March 18, 2024: Journal of Thoracic and Cardiovascular Surgery
https://read.qxmd.com/read/38505018/donor-management-and-extremely-high-donor-lung-utilization-rate-in-japan
#7
REVIEW
Yasushi Hoshikawa, Yasushi Matsuda, Juntaro Ashikari
Owing to the extremely short supply of donor lungs in Japan, a unique medical consultant (MC) system was initiated in 2002 to increase the organ availability through intensive management of donors. First, heart transplant surgeons were sent to procurement hospitals as MCs to assess donor organ function and provide intensive care to donors. MCs requested that donor attending doctors perform frequent phlegm aspiration with a bronchoscope, leading to a higher lung availability and better outcomes after lung transplantation...
February 29, 2024: Journal of Thoracic Disease
https://read.qxmd.com/read/38503386/impact-of-controlled-hypothermic-preservation-on-outcomes-following-heart-transplantation
#8
JOURNAL ARTICLE
David D'Alessandro, Jacob Schroder, Dan M Meyer, Andrija Vidic, Yasuhiro Shudo, Scott Silvestry, Marzia Leacche, Christopher M Sciortino, Maria Rodrigo, Si M Pham, Hannah Copeland, Jeffrey P Jacobs, Masashi Kawabori, Koji Takeda, Andreas Zuckermann
BACKGROUND: Severe primary graft dysfunction (PGD) is a major cause of early mortality after heart transplant. but the impact of donor organ preservation conditions on severity of PGD and survival have not been well characterized. METHODS: Data from US adult heart-transplant recipients in the GUARDIAN-Heart registry (NCT04141605) were analyzed to quantify PGD severity (stratified by ISHLT definition), mortality, and associated risk factors. The independent contributions of organ-preservation method (traditional ice storage versus controlled hypothermic preservation) and ischemic time were analyzed using propensity matching and logistic regression...
March 17, 2024: Journal of Heart and Lung Transplantation
https://read.qxmd.com/read/38502147/impella-5-5-bridge-to-heart-transplant-an-institutional-series-and-a-closer-look-at-device-removal-technique
#9
JOURNAL ARTICLE
Jessica S Clothier, Serge Kobsa, Jonathan Praeger, Markian Bojko, Anahat Dhillon, Ajay Vaidya, Raymond Lee
Limited donor organ availability often necessitates mechanical circulatory support, and recently the Impella 5.5, as a bridge to heart transplant. Of 175 Impella 5.5-supported patients at our institution, 45 underwent transplantation in the largest series to date, for whom we analyzed outcomes. Two methods of complete device explant were evaluated: central Impella transection and removal via axillary graft. Median Impella days were 25 (16-41); median waitlist days were 21 (9-37). Eighty-nine percent (40/45) of patients had device placement via right axillary artery...
March 14, 2024: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://read.qxmd.com/read/38500255/long-term-outcomes-with-prolonged-release-tacrolimus-in-kidney-transplantation-a-retrospective-real-world-data-analysis
#10
JOURNAL ARTICLE
Wilfried Gwinner, Swapneel Anaokar, Martin Blogg, Birgit Hermann, Carola Del Pilar Repetur, Mario Schiffer
BACKGROUND Long-term real-world outcomes data for kidney transplant recipients (KTRs) converting from immediate-release tacrolimus (IRT) to prolonged-release tacrolimus (PRT) are limited. MATERIAL AND METHODS A retrospective, non-interventional review of adult KTRs treated with PRT for ≥1 month was conducted in Germany. Data were extracted from time of transplant (2008-2014) to 2018. Primary composite endpoints (graft loss, biopsy-confirmed acute rejection, graft dysfunction) and secondary endpoints (all-cause mortality, kidney function course, and tacrolimus dose/trough levels) were analyzed for sub-cohorts: de novo PRT, early conversion from IRT (within 6 months post-transplant), and late conversion (7 months to 3 years)...
March 19, 2024: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://read.qxmd.com/read/38488940/retrospective-analysis-of-the-perioperative-outcome-in-living-donor-kidney-transplantation-with-multiple-renal-arteries-does-accessory-vessel-ligation-affect-the-outcome
#11
JOURNAL ARTICLE
Jacob Schmidt, Robert Peters, Josef Mang, Bernhard Ralla, Diana Elena Moldovan, Julia Dagnæs-Hansen, Lutz Liefeldt, Klemens Budde, Markus Lerchbaumer, Frank Friedersdorff
PURPOSE: Accurate surgical reconstruction of arterial vascular supply is a crucial part of living kidney transplantation (LDKT). The presence of multiple renal arteries (MRA) in grafts can be challenging. In the present study, we investigated the impact of ligation versus anastomosis of small accessory graft arteries on the perioperative outcome. METHODS: Clinical and radiological outcomes of 51 patients with MRA out of a total of 308 patients who underwent LDKT with MRA between 2011 and 2020 were stratified in two groups and analyzed...
March 15, 2024: World Journal of Urology
https://read.qxmd.com/read/38488011/b-cells-mediate-lung-ischemia-reperfusion-injury-by-recruiting-classical-monocytes-via-synergistic-b-cell-receptor-tlr4-signaling
#12
JOURNAL ARTICLE
Khashayar Farahnak, Yun Zhu Bai, Yuhei Yokoyama, Deniz B Morkan, Zhiyi Liu, Junedh M Amrute, Alejandro De Filippis Falcon, Yuriko Terada, Fuyi Liao, Wenjun Li, Hailey M Shepherd, Ramsey R Hachem, Varun Puri, Kory J Lavine, Andrew E Gelman, Ankit Bharat, Daniel Kreisel, Ruben G Nava
Ischemia/reperfusion injury-mediated (IRI-mediated) primary graft dysfunction (PGD) adversely affects both short- and long-term outcomes after lung transplantation, a procedure that remains the only treatment option for patients suffering from end-stage respiratory failure. While B cells are known to regulate adaptive immune responses, their role in lung IRI is not well understood. Here, we demonstrated by intravital imaging that B cells are rapidly recruited to injured lungs, where they extravasate into the parenchyma...
January 23, 2024: Journal of Clinical Investigation
https://read.qxmd.com/read/38485662/does-lung-procurement-and-exposure-to-perfadex-impact-heart-transplantation-outcomes
#13
JOURNAL ARTICLE
David Blitzer, David A Baran, Seth Lirette, Hannah Copeland
INTRODUCTION: Some studies have shown increased incidence of Primary Graft Dysfunction (PGD) after heart and lung procurement for heart transplant recipients. There have been limited investigations of the impact of lung procurement on heart procurement and the potential effects of the exposure to the type of lung preservation solution, the volume of the lung preservation solution and adequacy of decompression of the heart during heart and lung procurement and the impact on heart transplant outcomes...
March 2024: Clinical Transplantation
https://read.qxmd.com/read/38467592/sequential-normothermic-regional-perfusion-and-end-ischemic-ex-situ-machine-perfusion-allow-the-safe-use-of-very-old-dcd-donors-in-liver-transplantation
#14
JOURNAL ARTICLE
Francesco Torri, Emanuele Balzano, Fabio Melandro, Paolo Maremmani, Pietro Bertini, Paolo Lo Pane, Matilde Masini, Maria Isabella Rotondo, Serena Babboni, Serena Del Turco, Stefano Antonelli, Vincenzo De Tata, Giandomenico Biancofiore, Fabio Guarracino, Aldo Paolicchi, Paolo De Simone, Giuseppina Basta, Davide Ghinolfi
BACKGROUND: In Italy, 20 min of continuous, flat-line electrocardiogram are required for death declaration. Despite prolonged warm ischemia time, Italian centers reported good outcomes in controlled donation after circulatory death (cDCD) liver transplantation by combining normothermic regional and end-ischemic machine perfusion (MP). The aim of this study was to evaluate the safety and feasibility of the use of septuagenarian and octogenarian cDCD donors with this approach. METHODS: All cDCD older than 70 y were evaluated during normothermic regional perfusion and then randomly assigned to dual hypothermic or normothermic MP...
March 12, 2024: Transplantation
https://read.qxmd.com/read/38466306/beating-heart-transplant-procedures-using-organs-from-donors-with-circulatory-death
#15
JOURNAL ARTICLE
Aravind Krishnan, Chawannuch Ruaengsri, Brandon A Guenthart, Yasuhiro Shudo, Hanjay Wang, Michael R Ma, John Ward MacArthur, William Hiesinger, Y Joseph Woo
IMPORTANCE: The use of ex vivo normothermic organ perfusion has enabled the use of deceased after circulatory death (DCD) donors for heart transplants. However, compared with conventional brain death donation, DCD heart transplantation performed with ex vivo organ perfusion involves an additional period of warm and cold ischemia, exposing the allograft to multiple bouts of ischemia reperfusion injury and may contribute to the high rates of extracorporeal membrane oxygenation usage after DCD heart transplantation...
March 4, 2024: JAMA Network Open
https://read.qxmd.com/read/38463463/the-predictive-value-of-graft-viability-and-bioenergetics-testing-towards-the-outcome-in-liver-transplantation
#16
JOURNAL ARTICLE
Andras T Meszaros, Annemarie Weissenbacher, Melanie Schartner, Tim Egelseer-Bruendl, Martin Hermann, Jasmin Unterweger, Christa Mittelberger, Beatrix A Reyer, Julia Hofmann, Bettina G Zelger, Theresa Hautz, Thomas Resch, Christian Margreiter, Manuel Maglione, Timea Komlódi, Hanno Ulmer, Benno Cardini, Jakob Troppmair, Dietmar Öfner, Erich Gnaiger, Stefan Schneeberger, Rupert Oberhuber
Donor organ biomarkers with sufficient predictive value in liver transplantation (LT) are lacking. We herein evaluate liver viability and mitochondrial bioenergetics for their predictive capacity towards the outcome in LT. We enrolled 43 consecutive patients undergoing LT. Liver biopsy samples taken upon arrival after static cold storage were assessed by histology, real-time confocal imaging analysis (RTCA), and high-resolution respirometry (HRR) for mitochondrial respiration of tissue homogenates. Early allograft dysfunction (EAD) served as primary endpoint...
2024: Transplant International
https://read.qxmd.com/read/38463149/primary-non-function-of-hepatic-allograft-with-preexisting-microvesicular-steatosis-foamy-degeneration-and-mild-large-droplet-macrovesicular-steatosis
#17
Melissa E Limia, Xiu Li Liu, Jennifer Yu, Kathleen Byrnes
It has been established that more than mild large-droplet macrovesicular steatosis (LD-MAS) is associated with increased risk of graft non-function. In contrast, even severe small-droplet macrovesicular steatosis (SD-MAS) has been found to be less prognostically significant. It remains unclear if a donor liver with diffuse microvesicular steatosis is associated with an increased risk of graft dysfunction. A 56-year-old male with alcoholic cirrhosis was transplanted with a liver from a 42-year-old overweight male donor after brain death...
February 2024: Gastroenterology Research
https://read.qxmd.com/read/38460671/capturing-the-evolving-landscape-of-primary-graft-dysfunction-after-heart-transplantation-will-achilles-ever-overtake-the-tortoise
#18
JOURNAL ARTICLE
Melana Yuzefpolskaya, Paolo C Colombo
No abstract text is available yet for this article.
March 7, 2024: Journal of Cardiac Failure
https://read.qxmd.com/read/38434572/fabrication-of-bioengineered-corneal-endothelial-grafts-using-an-allogeneic-cornea-derived-matrix
#19
REVIEW
Lijie Xie, Xiaojuan Dong, Jianping Ji, Chen Ouyang, Jing Wu, Chao Hou, Ting Huang
Corneal endothelial keratoplasty has been the primary treatment method of endothelial decompensation, but it is often limited in clinical practice due to global shortage of donor cornea. Here, we explored using an ultra-thin allogeneic cornea-derived matrix (uACM) films as a substrate for constructing bioengineered corneal endothelial grafts. We evaluated the films' optical, mechanical, and structural properties, and measured the composition of the extracellular matrix. The uACM was an ultrathin and curved cornea-shaped film with favorable optical and mechanical properties...
April 2024: Materials today. Bio
https://read.qxmd.com/read/38429191/impact-of-the-new-definition-of-pulmonary-hypertension-on-the-prevalence-of-primary-graft-dysfunction-in-lung-transplant-recipients
#20
JOURNAL ARTICLE
Víctor M Mora-Cuesta, Amaya Martínez-Meñaca, David Iturbe-Fernández, Sandra Tello-Mena, Sheila Izquierdo-Cuervo, Tamara García-Camarero, Aritz Gil-Ongay, Laura Sánchez-Moreno, Pilar Alonso-Lecue, Sara Naranjo-Gozalo, José M Cifrián-Martínez
BACKGROUND AND AIM: Pulmonary hypertension (PH) secondary to lung disease (Group-3 PH) is the second leading cause of PH. The role of PH as a risk factor for primary graft dysfunction (PGD) following lung transplant (LT) is controversial. OBJECTIVE: To assess the impact that the new definition of PH had on the prevalence of PH in patients with advanced lung disease-candidate for LT, and its association with the occurrence of PGD. METHOD: A retrospective study was performed in all patients undergoing cardiac catheterisation referred for consideration as candidates to LT in a centre between 1 January 2017 and 31 December 2022...
February 29, 2024: Heart, Lung & Circulation
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