Sachendra S Bais, Yashika Ratra, Naseem A Khan, Rakesh Pandey, Pramod K Kushawaha, Shailly Tomar, Guruprasad Medigeshi, Abhyudai Singh, Soumen Basak
Chandipura virus (CHPV), a cytoplasmic RNA virus, has been implicated in several outbreaks of acute encephalitis in India. Despite its human health relevance, how CHPV interacts with the host signaling machinery remains obscure. In response to viral infections, mammalian cells activate RelA/NF-κB heterodimers, which induce genes encoding interferon-β and other immune mediators. Therefore, RelA is generally considered to be an antiviral transcription factor. However, RelA activates a wide spectrum of genes in physiological settings and there is a paucity of direct genetic evidence substantiating antiviral RelA functions...
May 1, 2019: Journal of Virology