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https://www.readbyqxmd.com/read/28103507/circular-banp-an-upregulated-circular-rna-that-modulates-cell-proliferation-in-colorectal-cancer
#1
Mingchen Zhu, Yijun Xu, Yun Chen, Feng Yan
Circular RNAs (circRNAs) are recently identified as widespread and diverse endogenous noncoding RNAs that may harbor vital functions in human and animals. However, the role of circRNAs in the process of tumorigenesis and development of colorectal cancer (CRC) remains vague. Here we characterized the circRNA expression profile from three paired CRC cancerous and adjacent normal tissues by human circRNA array, and identified 136 significantly overexpressed circRNAs and 243 downregulated circRNAs in CRC cancerous tissues (>2-fold changes)...
January 16, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28103495/emotion-socialization-and-internalizing-behavior-problems-in-diverse-youth-a-bidirectional-relationship-across-childhood
#2
Naomi V Rodas, Denise A Chavira, Bruce L Baker
Mothers' and fathers' emotion socialization (ES) practices have been widely associated with child socioemotional outcomes. To extend this research, we examined the bidirectional relationship between parent ES practices (supportive and non-supportive parenting) and internalizing behavior problems in children of Anglo and Latino parents. Participants were 182 mothers and 162 fathers and their children with or without intellectual disability (ID). We compared the stability of mother and father ES practices across child ages 4-8...
January 16, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/28103459/-cultural-competence-in-intervention-with-immigrants-a-comparative-analysis-between-health-professionals-social-workers-and-police-officers
#3
Mariana Gonçalves, Marlene Matos
INTRODUCTION: Cultural diversity places increased demands on services to multicultural populations, so the development of cultural competence by help professionals is currently a concern in institutional practices. MATERIAL AND METHODS: This study evaluated the perception of cultural competence of help professional of three distinct areas: health services, social services and criminal police. Through an online questionnaire, we questioned the perception of cultural competence, at four dimensions: cultural awareness, cultural knowledge, technical skills, and organizational support...
October 2016: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28103392/a-peroxygenase-from-chaetomium-globosum-catalyzes-the-selective-oxygenation-of-testosterone
#4
Jan Kiebist, Kai-Uwe Schmidtke, Jörg Zimmermann, Harald Kellner, Nico Jehmlich, René Ullrich, Daniel Zänder, Martin Hofrichter, Katrin Scheibner
Unspecific peroxygenases (UPO, EC 1.11.2.1) secreted by fungi open an efficient way to selectively oxyfunctionalize diverse organic substrates including less activated hydrocarbons by transferring peroxide-borne oxygen. Herein, we investigated a cell-free approach to incorporate epoxy and hydroxyl functionalities directly into the bulky molecule of testosterone by a novel unspecific peroxygenase that was produced by the ascomycetous fungus Chaetomium globosum in a complex medium rich in carbon and nitrogen...
January 19, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/28103318/static-and-evolving-norovirus-genotypes-implications-for-epidemiology-and-immunity
#5
Gabriel I Parra, R Burke Squires, Consolee K Karangwa, Jordan A Johnson, Cara Lepore, Stanislav V Sosnovtsev, Kim Y Green
Noroviruses are major pathogens associated with acute gastroenteritis worldwide. Their RNA genomes are diverse, with two major genogroups (GI and GII) comprised of at least 28 genotypes associated with human disease. To elucidate mechanisms underlying norovirus diversity and evolution, we used a large-scale genomics approach to analyze human norovirus sequences. Comparison of over 2000 nearly full-length ORF2 sequences representing most of the known GI and GII genotypes infecting humans showed a limited number (≤5) of distinct intra-genotypic variants within each genotype, with the exception of GII...
January 19, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28103307/plant-family-specific-impacts-of-petroleum-pollution-on-biodiversity-and-leaf-chlorophyll-content-in-the-amazon-rainforest-of-ecuador
#6
Paul Arellano, Kevin Tansey, Heiko Balzter, Markus Tellkamp
In recent decades petroleum pollution in the tropical rainforest has caused significant environmental damage in vast areas of the Amazon region. At present the extent of this damage is not entirely clear. Little is known about the specific impacts of petroleum pollution on tropical vegetation. In a field expedition to the Ecuadorian Amazon over 1100 leaf samples were collected from tropical trees in polluted and unpolluted sites. Plant families were identified for 739 of the leaf samples and compared between sites...
2017: PloS One
https://www.readbyqxmd.com/read/28103291/the-gut-brain-axis-in-healthy-females-lack-of-significant-association-between-microbial-composition-and-diversity-with-psychiatric-measures
#7
Susan C Kleiman, Emily C Bulik-Sullivan, Elaine M Glenny, Stephanie C Zerwas, Eun Young Huh, Matthew C B Tsilimigras, Anthony A Fodor, Cynthia M Bulik, Ian M Carroll
OBJECTIVE: This study examined associations between the composition and diversity of the intestinal microbiota and measures of depression, anxiety, eating disorder psychopathology, stress, and personality in a group of healthy adult females. METHODS: Female participants (n = 91) ages 19-50 years with BMI 18.5-25 kg/m2 were recruited from central North Carolina between July 2014 and March 2015. Participants provided a single fecal sample and completed an online psychiatric questionnaire that included five measures: (i) Beck Anxiety Inventory; (ii) Beck Depression Inventory-II; (iii) Eating Disorder Examination-Questionnaire; (iv) Perceived Stress Scale; and (v) Mini International Personality Item Pool...
2017: PloS One
https://www.readbyqxmd.com/read/28103271/early-stages-of-sea-level-rise-lead-to-decreased-salt-marsh-plant-diversity-through-stronger-competition-in-mediterranean-climate-marshes
#8
Akana E Noto, Jonathan B Shurin
Climate change shuffles species ranges and creates novel interactions that may either buffer communities against climate change or exacerbate its effect. For instance, facilitation can become more prevalent in salt marshes under stressful conditions while competition is stronger in benign environments. Sea-level rise (SLR) is a consequence of climate change that affects the distribution of stress from inundation and salinity. To determine how interactions early in SLR are affected by changes in these two stressors in Mediterranean-climate marshes, we transplanted marsh turfs to lower elevations to simulate SLR and manipulated cover of the dominant plant species, Salicornia pacifica (formerly Salicornia virginica)...
2017: PloS One
https://www.readbyqxmd.com/read/28103247/bombyx-mori-p-element-somatic-inhibitor-bmpsi-is-a-key-auxiliary-factor-for-silkworm-male-sex-determination
#9
Jun Xu, Shuqing Chen, Baosheng Zeng, Anthony A James, Anjiang Tan, Yongping Huang
Manipulation of sex determination pathways in insects provides the basis for a wide spectrum of strategies to benefit agriculture and public health. Furthermore, insects display a remarkable diversity in the genetic pathways that lead to sex differentiation. The silkworm, Bombyx mori, has been cultivated by humans as a beneficial insect for over two millennia, and more recently as a model system for studying lepidopteran genetics and development. Previous studies have identified the B. mori Fem piRNA as the primary female determining factor and BmMasc as its downstream target, while the genetic scenario for male sex determination was still unclear...
January 19, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28103238/weak-genetic-structure-in-northern-african-dromedary-camels-reflects-their-unique-evolutionary-history
#10
Youcef Amine Cherifi, Suheil Bechir Semir Gaouar, Rosangela Guastamacchia, Khalid Ahmed El-Bahrawy, Asmaa Mohammed Aly Abushady, Abdoallah Aboelnasr Sharaf, Derradji Harek, Giovanni Michele Lacalandra, Nadhira Saïdi-Mehtar, Elena Ciani
Knowledge on genetic diversity and structure of camel populations is fundamental for sustainable herd management and breeding program implementation in this species. Here we characterized a total of 331 camels from Northern Africa, representative of six populations and thirteen Algerian and Egyptian geographic regions, using 20 STR markers. The nineteen polymorphic loci displayed an average of 9.79 ± 5.31 alleles, ranging from 2 (CVRL8) to 24 (CVRL1D). Average He was 0.647 ± 0.173. Eleven loci deviated significantly from Hardy-Weinberg proportions (P<0...
2017: PloS One
https://www.readbyqxmd.com/read/28103228/human-specific-cortical-synaptic-connections-and-their-plasticity-is-that-what-makes-us-human
#11
Joana Lourenço, Alberto Bacci
One outstanding difference between Homo sapiens and other mammals is the ability to perform highly complex cognitive tasks and behaviors, such as language, abstract thinking, and cultural diversity. How is this accomplished? According to one prominent theory, cognitive complexity is proportional to the repetition of specific computational modules over a large surface expansion of the cerebral cortex (neocortex). However, the human neocortex was shown to also possess unique features at the cellular and synaptic levels, raising the possibility that expanding the computational module is not the only mechanism underlying complex thinking...
January 2017: PLoS Biology
https://www.readbyqxmd.com/read/28103117/wee1-and-cdc25-are-controlled-by-conserved-pp2a-dependent-mechanisms-in-fission-yeast
#12
Rafael Lucena, Maria Alcaide-Gavilán, Steph D Anastasia, Douglas R Kellogg
Wee1 and Cdc25 are conserved regulators of mitosis. Wee1 is a kinase that delays mitosis via inhibitory phosphorylation of Cdk1, while Cdc25 is a phosphatase that promotes mitosis by removing the inhibitory phosphorylation. Although Wee1 and Cdc25 are conserved proteins, it has remained unclear whether their functions and regulation are conserved across diverse species. Here, we analyzed regulation of Wee1 and Cdc25 in fission yeast. Both proteins undergo dramatic cell cycle-dependent changes in phosphorylation that are dependent upon PP2A associated with the regulatory subunit Pab1...
January 19, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28103112/potassium-iodate-differently-regulates-the-proliferation-migration-and-invasion-of-human-thyroid-cancer-cells-via-modulating-mir-146a
#13
Yan Liu, Hong Li, Jiayue Zhang, Xu Gao
The effects of different doses of potassium iodate (KIO3) on the malignancy of thyroid cancer were investigated. Results showed that the proliferation, migration, and invasion of SW579 thyroid cancer cells were improved by 10(-6) M KIO3, which was associated with microRNA(miR)-146a deficit; 10(-2) M KIO3 significantly enhanced miR-146a level and suppressed SW579 cell proliferation, migration, and invasion. The diverse effects of KIO3 on SW579 cells were associated with the expression changes in miR-146a targets, Bcl-2, Bax, and caspase-3...
January 19, 2017: Cancer Investigation
https://www.readbyqxmd.com/read/28103029/diverse-reactions-of-thiophenes-selenophenes-and-tellurophenes-with-strongly-oxidizing-i-iii-phi-l-2-reagents
#14
Sathsara Egalahewa, Mohammad Albayer, Antonino Aprile, Jason L Dutton
We report the outcomes of the reactions of aromatic group 16 thiophene, selenophene, and tellurophene rings with the I(III) oxidants PhI(OAc)(OTf) and [PhI(Pyr)2][OTf]2 (Pyr = pyridine). In all reactions, oxidative processes take place, with generation of PhI as the reduction product. However, with the exception of tellurophene with PhI(OAc)(OTf), +4 oxidation state complexes are not observed, but rather a variety of other processes occur. In general, where a C-H unit is available on the 5-membered ring, an electrophilic aromatic substitution reaction of either -IPh or pyridine onto the ring occurs...
January 19, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28103013/building-nanoporous-metal-organic-frameworks-armour-on-fibers-for-high-performance-composite-materials
#15
Xiaobin Yang, Xu Jiang, Yudong Huang, Zhanhu Guo, Lu Shao
The nanoporous Metal-Organic Frameworks (MOFs) "armour" is in situ intergrown onto the surfaces of carbon fibers (CFs) by nitric acid oxidization to supply nucleation sites, and serves as a novel interfacial linker between the fiber and polymer matrix and a smart cushion to release interior and exterior applied forces. Simultaneous enhancements of the interfacial and interlaminar shear strength as well as the tensile strength of CFs were achieved. With the aid of an ultrasonic "cleaning" process, the optimized surface energy and tensile strength of CFs with a MOF "armour" are 83...
January 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28102964/plasmonic-chirality-imprinting-on-nucleobase-displaying-supramolecular-nanohelices-by-metal-nucleobase-recognition
#16
Yiyang Lin, E Thomas Pashuck, Michael R Thomas, Nadav Amdursky, Shih-Ting Wang, Lesley W Chow, Molly M Stevens
Supramolecular self-assembly is an important process that enables the conception of complex structures mimicking biological motifs. Herein, we constructed helical fibrils through chiral self-assembly of nucleobase-peptide conjugates (NPCs), where achiral nucleobases are helically displayed on the surface of fibrils, comparable to polymerized nucleic acids. Selective binding between DNA and the NPC fibrils was observed with fluorescence polarization. Taking advantage of metal-nucleobase recognition, we highlight the possibility of deposition/assembly of plasmonic nanoparticles onto the fibrillar constructs...
January 19, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28102902/cover-image-volume-232-number-5-may-2017
#17
Toshiaki Tanaka, Kaoru Goto, Mitsuyoshi Iino
Cover: The cover image, by Toshiaki Tanaka, Kaoru Goto, and Mitsuyoshi Iino, is based on the Review Article Diverse Functions and Signal Transduction of the Exocyst Complex in Tumor Cells, DOI 10.1002/jcp.25619.
May 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28102736/dengue-and-zika-viruses-subvert-reticulophagy-by-ns2b3-mediated-cleavage-of-fam134b
#18
Nicholas J Lennemann, Carolyn B Coyne
The endoplasmic reticulum (ER) is exploited by a number of diverse viruses during their infectious life cycles. Flaviviruses, including dengue virus (DENV) and Zika virus (ZIKV), utilize the ER as a source of membranes to establish their replication organelles and to facilitate their assembly and eventual maturation along the secretory pathway. In order to maintain normal homeostasis, host cells have evolved highly efficient processes to dynamically regulate the ER, such as through reticulophagy, a selective form of autophagy that leads to ER degradation...
January 19, 2017: Autophagy
https://www.readbyqxmd.com/read/28102692/de-novo-assembly-of-highly-substituted-morpholines-and-piperazines
#19
Pravin Patil, Rudrakshula Madhavachary, Katarzyna Kurpiewska, Justyna Kalinowska-Tłuścik, Alexander Dömling
The morpholine and piperazine with their remarkable physical and biochemical properties are popular heterocycles in organic and medicinal chemistry used in rational property design. However, in the majority of cases these rings are added to an existing molecule in a building block approach thus limiting their substitution pattern and diversity. Here we introduce a versatile de novo synthesis of the morpholine and piperazine rings using multicomponent reaction chemistry. The large scale amenable building blocks can be further substituted at up to four positions, making this a very versatile scaffold synthesis strategy...
January 19, 2017: Organic Letters
https://www.readbyqxmd.com/read/28102571/developing-a-cultural-competence-inventory-for-nurses-in-china
#20
D Cai, W Kunaviktikul, A Klunklin, A Sripusanapan, P K Avant
AIM: To develop and psychometrically test the Cultural Competence Inventory for Nurses in China. BACKGROUND: Cultural competence is expected worldwide from nurses due to the increasing cultural diversity of people in healthcare establishments. Yet, no cultural competence framework or instrument for nurses has been identified to guide nursing practice in China where the cultural diversity of the populations and the characteristics of the healthcare system are different from those of the West...
January 19, 2017: International Nursing Review
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