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https://www.readbyqxmd.com/read/28340488/national-and-sub-national-age-sex-specific-and-cause-specific-mortality-and-disability-adjusted-life-years-dalys-attributable-to-household-air-pollution-from-solid-cookfuel-use-hap-in-iran-1990-2013
#1
Mehrnoosh Abtahi, Ali Koolivand, Sina Dobaradaran, Kamyar Yaghmaeian, Anoushiravan Mohseni-Bandpei, Shokooh Sadat Khaloo, Sahand Jorfi, Reza Saeedi
National and sub-national mortality, years of life lost due to premature mortality (YLLs), years lived with disability (YLDs) and disability-adjusted life years (DALYs) for household air pollution from solid cookfuel use (HAP) in Iran, 1990-2013 were estimated based on the Global Burden of Disease Study 2013 (GBD 2013). The burden of disease attributable to HAP was quantified by the comparative risk assessment method using four inputs: (1) exposure to HAP, (2) the theoretical minimum risk exposure level (TMREL), (3) exposure-response relationships of related causes (4) disease burden of related causes...
March 21, 2017: Environmental Research
https://www.readbyqxmd.com/read/28339769/incidence-and-potential-risk-factors-for-hospital-acquired-pneumonia-in-an-emergency-department-of-surgery
#2
Marie Stenlund, Rune Sjödahl, R N Pia Yngman-Uhlin
Objective: Hospital-acquired pneumonia (HAP) is associated with high mortality and is the second most common nosocomial infection. The aim of this study was to calculate the incidence and to identify potential risk factors for HAP in an emergency ward for surgical patients admitted because of acute abdomen or trauma. Design: A structured review of medical records was conducted. Patients diagnosed with pneumonia >48 h after admittance, were compared with a randomly chosen age-matched reference group...
February 23, 2017: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/28339215/discovery-and-pre-clinical-characterization-of-a-3-rd-generation-4-h-heteroaryldihydropyrimidine-hap-analogues-as-hepatitis-b-virus-hbv-capsid-inhibitors
#3
Zongxing Qiu, Xianfeng Lin, Weixing Zhang, Mingwei Zhou, Lei Guo, Buelent Kocer, Guolong Wu, Zhisen Zhang, Haixia Liu, Houguang Shi, Buyu Kou, Taishan Hu, Yimin Hu, Mengwei Huang, S Frank Yan, Zhiheng Xu, Zheng Zhou, Ning Qin, Yue Fen Wang, Shuang Ren, Hongxia Qiu, Yuxia Zhang, Yi Zhang, Xiaoyue Wu, Kai Sun, Sheng Zhong, Jianxun Xie, Giorgio Ottaviani, Yuan Zhou, Lina Zhu, Xiaojun Tian, Liping Shi, Fang Shen, Yi Mao, Xue Zhou, Lu Gao, John A T Young, Jim Zhen Wu, Guang Yang, Alexander V Mayweg, Hong C Shen, Guozhi Tang, Wei Zhu
Described herein are the discovery and structure-activity relationship (SAR) studies of the 3(rd) generation 4-H heteroaryldihydropyrimidines (4-H HAPs) featuring the introduction of a C6 carboxyl group as novel HBV capsid inhibitors. This new series of 4-H HAPs showed improved anti-HBV activity and better drug-like properties compared to the 1(st) and 2(nd) generation 4-H HAPs. X-ray crystallographic study of analogue 12 (HAP_R01) with Cp149 Y132A mutant hexamer clearly elucidated the role of C6 carboxyl group played for the increased binding affinity, which formed strong hydrogen bonding interactions with capsid protein and coordinated waters...
March 24, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28335548/study-of-different-variants-of-mo-enzyme-crarc-and-the-interaction-with-its-partners-crcytb5-r-and-crcytb5-1
#4
Alejandro Chamizo-Ampudia, Aurora Galvan, Emilio Fernandez, Angel Llamas
The mARC (mitochondrial Amidoxime Reducing Component) proteins are recently discovered molybdenum (Mo) Cofactor containing enzymes. They are involved in the reduction of several N-hydroxylated compounds (NHC) and nitrite. Some NHC are prodrugs containing an amidoxime structure or mutagens such as 6-hydroxylaminopurine (HAP). We have studied this protein in the green alga Chlamydomonas reinhardtii (crARC). Interestingly, all the ARC proteins need the reducing power supplied by other proteins. It is known that crARC requires a cytochrome b₅ (crCytb5-1) and a cytochrome b₅ reductase (crCytb5-R) that form an electron transport chain from NADH to the substrates...
March 21, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28332574/natural-variation-in-ctb4a-enhances-rice-adaptation-to-cold-habitats
#5
Zhanying Zhang, Jinjie Li, Yinghua Pan, Jilong Li, Lei Zhou, Hongli Shi, Yawen Zeng, Haifeng Guo, Shuming Yang, Weiwei Zheng, Jianping Yu, Xingming Sun, Gangling Li, Yanglin Ding, Liang Ma, Shiquan Shen, Luyuan Dai, Hongliang Zhang, Shuhua Yang, Yan Guo, Zichao Li
Low temperature is a major factor limiting rice productivity and geographical distribution. Improved cold tolerance and expanded cultivation to high-altitude or high-latitude regions would help meet growing rice demand. Here we explored a QTL for cold tolerance and cloned the gene, CTB4a (cold tolerance at booting stage), encoding a conserved leucine-rich repeat receptor-like kinase. We show that different CTB4a alleles confer distinct levels of cold tolerance and selection for variation in the CTB4a promoter region has occurred on the basis of environmental temperature...
March 23, 2017: Nature Communications
https://www.readbyqxmd.com/read/28330763/ph-responsive-controlled-release-of-anti-cancer-hydrophobic-drugs-from-sodium-alginate-and-hydroxyapatite-bi-coated-iron-oxide-nanoparticles
#6
Danushika C Manatunga, Rohini M de Silva, K M Nalin de Silva, Nuwan de Silva, Shiva Bhandari, Yoke Khin Yap, N Pabakara Costha
Developing a drug carrier system which could perform targeted and controlled release over a period of time is utmost concern in the pharmaceutical industry. This is more relevant when designing drug carriers for poorly water soluble drug molecules such as curcumin and 6-gingerol. Development of a drug carrier system which could overcome these limitations and perform controlled and targeted drug delivery is beneficial. This study describes a promising approach for the design of novel pH sensitive sodium alginate, hydroxyapatite bilayer coated iron oxide nanoparticle composite (IONP/HAp-NaAlg) via the co-precipitation approach...
March 18, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28328959/kras-and-vegf-gene-3-utr-single-nucleotide-polymorphisms-predicted-susceptibility-in-colorectal-cancer
#7
Minnan Yang, Xiuli Xiao, Xiaorui Xing, Xin Li, Tian Xia, Hanan Long
Single nucleotide polymorphisms (SNPs) in tumor-related genes have been reported to play important roles in cancer development. Recent studies have shown that 3'-untranslated regions (UTR) polymorphisms are associated with the occurrence and prognosis of cancers. The aim of this study is to analyze the association between KRAS and VEGF gene 3'-UTR SNPs and genetic susceptibility to colorectal cancer (CRC). In this case-control study of 371 CRC cases and 246 healthy controls, we analyzed the association between one SNP (rs1137188G > A) in the KRAS gene and four SNPs (rs3025039C > T, rs3025040C > T, rs3025053G > A and rs10434A > G) in the VEGF gene and CRC susceptibility by the improved multiplex ligase detection reaction (iMLDR) method...
2017: PloS One
https://www.readbyqxmd.com/read/28325103/fabrication-and-characterization-of-dendrimer-functionalized-nano-hydroxyapatite-and-its-application-in-dentin-tubule-occlusion
#8
Xuandong Lin, Fangfang Xie, Xueling Ma, Yuhong Hao, Hejia Qin, Jindong Long
The occlusion of dentinal tubules is an effective method to alleviate the symptoms of dentin hypersensitivity. In this paper, we successfully modified nano-hydroxyapatite (n-HAP)with carboxyl-terminated polyamidoamine dendrimers by an aqueous-based chemical method and verified by fourier transform infrared spectroscopy (FTIR) and transmission electron microscope(TEM). Then the demineralization dentin discs were randomly divided into 4 groups, corresponding to subsequent brushing experiments: deionized water and kept in artificial saliva (AS), dendrimer-functionalized n-HAP and stored in AS, n-HAP and saved in AS, dendrimer-functionalized n-HAP and stored in deionized water...
March 22, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28318476/p-and-ca-digestibility-is-increased-in-broiler-diets-supplemented-with-the-high-phytase-highphy-wheat
#9
D Scholey, E Burton, N Morgan, C Sanni, C K Madsen, G Dionisio, H Brinch-Pedersen
Around 70% of total seed phosphorus is represented by phytate which must be hydrolysed to be bioavailable in non-ruminant diets. The limited endogenous phytase activity in non-ruminant animals make it common practice to add an exogenous phytase source to most poultry and pig feeds. The mature grain phytase activity (MGPA) of cereal seeds provides a route for the seeds themselves to contribute to phytate digestion, but MGPA varies considerably between species and most varieties in current use make negligible contributions...
March 20, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28296648/salivary-acquired-pellicle-inspired-dpspseekc-peptide-for-the-restoration-of-demineralized-tooth-enamel
#10
Yinxin Yang, Bo Yang, Mingze Li, Yaning Wang, Xiao Yang, Jianshu Li
Salivary acquired pellicle (SAP) is a layer of proteins and glycoproteins of salivary origin that tightly coat the tooth surface. Statherin is an important part of the SAP. The initial six-peptide sequence DpSpSEEK (where pS denotes phosphorylated serine) of the N-terminus of statherin can be immobilized on a hydroxyapatite (HAP) surface and the negatively charged domains of the DpSpSEEK side chain can catch free Ca(2+) in saliva due to the charge adsorption effect. In order to prepare more functional materials based on DpSpSEEK, we designed a cysteine-labeled peptide sequence DpSpSEEKC, which could conjugate other macromolecules by forming a sulfur-based linkage...
March 15, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28292382/comparison-of-harmless-acute-pancreatitis-score-with-ranson-s-score-in-predicting-the-severity-of-acute-pancreatitis
#11
Hamad Hadi Al-Qahtani, Mohammed Khurshid Alam, Muhammad Waheed
OBJECTIVE: To determine the predictability of harmless acute pancreatitis score (HAPS) in determining the severity of acute pancreatitis (AP) and compare it with Ranson's score. STUDY DESIGN: Prospective cohort study. PLACE AND DURATION OF STUDY: King Saud Medical City, Riyadh, Kingdom of Saudi Arabia, between January 2012 and December 2015. METHODOLOGY: All patients admitted with AP at King Saud Medical City, Riyadh, during 2012 - 2015 were studied prospectively...
February 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28285622/real-life-effectiveness-of-improved-stoves-and-clean-fuels-in-reducing-pm2-5-and-co-systematic-review-and-meta-analysis
#12
REVIEW
Daniel Pope, Nigel Bruce, Mukesh Dherani, Kirstie Jagoe, Eva Rehfuess
BACKGROUND: 2.8 billion people cook with solid fuels, resulting in almost 3 million premature deaths from household air pollution (HAP). To date, no systematic assessment of impacts on HAP of 'improved' stove and clean fuel interventions has been conducted. OBJECTIVE: This systematic review synthesizes evidence for changes in kitchen and personal PM2.5 and carbon monoxide (CO) following introduction of 'improved' solid fuel stoves and cleaner fuels in low- and middle-income countries (LMIC)...
April 2017: Environment International
https://www.readbyqxmd.com/read/28285159/hydroxyapatite-reinforced-inherent-rgd-containing-silk-fibroin-composite-scaffolds-promising-platform-for-bone-tissue-engineering
#13
Sibaram Behera, Deboki Naskar, Sunaina Sapru, Promita Bhattacharjee, Tuli Dey, Ananta K Ghosh, Mahitosh Mandal, Subhas C Kundu
Replacement and repair of ectopic bone defects and traumatized bone tissues are done using porous scaffolds and composites. The prerequisites for such scaffolds include high mechanical strength, osseoconductivity and cytocompatibility. The present work is designed to address such requirements by fabricating a reinforced cytocompatible scaffold. Biocompatible silk protein fibroin collected from tropical non-mulberry tasar silkworm (Antheraea mylitta) is used to fabricate fibroin-hydroxyapatite (HAp) nanocomposite particles using chemical precipitation method...
March 8, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28278260/household-air-pollution-from-use-of-cooking-fuel-and-under-five-mortality-the-role-of-breastfeeding-status-and-kitchen-location-in-pakistan
#14
Sabrina Naz, Andrew Page, Kingsley Emwinyore Agho
Household air pollution (HAP) mainly from cooking fuel is one of the major causes of respiratory illness and deaths among young children in low and middle-income countries like Pakistan. This study investigates for the first time the association between HAP from cooking fuel and under-five mortality using the 2013 Pakistan Demographic and Health Survey (PDHS) data. Multi-level logistic regression models were used to examine the association between HAP and under-five mortality in a total of 11,507 living children across four age-groups (neonatal aged 0-28 days, post-neonatal aged 1-11 months, child aged 12-59 months and under-five aged 0-59 months)...
2017: PloS One
https://www.readbyqxmd.com/read/28278042/a-cell-attracting-composite-of-lumbar-fusion-cage
#15
Busra Gunay, Nesrin Hasirci, Vasif Hasirci
Lumbar fusion cages are devices used in spinal fusion procedures for disorders such as spondylosis and degenerative disc diseases that may occur due to age, trauma or genetic reasons. These devices are most frequently made of metals and polymers. The mechanical properties of such devices should be comparable to the bone to avoid stress shielding. Besides, cages should interact with the cells to prevent extrusion and achieve satisfactory fusion. In this study, poly(methylmethacrylate) (PMMA) and hydroxyapatite (HAp) were compounded to create products with HAp contents up to 40% (w/w), processed by hot melt extrusion and injection molded to produce composites with maximum polymer-mineral interaction...
March 13, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28269739/comparison-of-hexagonal-crystal-structures-between-fluorapatite-and-polytetrafluoroethylene
#16
REVIEW
Masayuki Okazaki
The crystallographic properties of fluorapatite (FAp) and polytetrafluoroethylene (PTFE) as biomedical materials were compared. Both materials contain fluorine and casually belong to the hexagonal crystal system. It is interesting that FAp is an inorganic ionic crystal, while PTFE is an organic covalent-bond crystal. Generally, fluorine contributes to the physicochemical stability and in some cases to the biocompatibility. The crystal structure of FAp was initially analyzed in 1930 by Náray-Szabó, although the analysis of hydroxyapatite (HAp) was markedly delayed until 1964...
2017: Bio-medical Materials and Engineering
https://www.readbyqxmd.com/read/28264613/pharmacokinetic-drug-evaluation-of-ceftobiprole-for-the-treatment-of-mrsa
#17
Karolyn S Horn, Larry H Danziger, Keith A Rodvold, Robert C Glowacki
Methicillin-resistant Staphylococcus aureus (MRSA), while decreasing in overall incidence, is still a prominent concern world-wide. New agents coming to market in the last 10 years allow practitioners to optimize treatment for MRSA infections. Ceftobiprole is a cephalosporin agent with MRSA activity, currently approved in selected countries for the treatment of community-acquired pneumonia and hospital-acquired pneumonia. Areas covered: Relevant literature regarding spectrum of activity, pharmacokinetics, pharmacodynamics, and clinical trials will be discussed...
March 17, 2017: Expert Opinion on Drug Metabolism & Toxicology
https://www.readbyqxmd.com/read/28261831/hydroxyapatite-nanoparticle-induced-mitochondrial-energy-metabolism-impairment-in-liver-cells-in-vitro-and-in-vivo-studies
#18
Yang Xue, Qingqing Chen, Jiao Sun
Hydroxyapatite nanoparticles (HAP-NPs) have been extensively developed as drug carriers, bone implants, coating materials, etc. in the human body. However, research focusing on the potential side effects of HAP-NPs on the mitochondria-associated energy metabolism in liver cells is lacking. In this study, HAP-NPs with a long diameter of 80 nm and a short diameter of 20 nm were evaluated for their ability to induce mitochondrial energy metabolism dysfunction in vitro and in vivo. In the in vitro system, the buffalo rat hepatocyte (BRL) cell line was directly exposed to the HAP-NPs...
March 6, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/28261504/thalamo-sensorimotor-functional-connectivity-correlates-with-world-ranking-of-olympic-elite-and-high-performance-athletes
#19
Zirui Huang, Henry Hap Davis Iv, Annemarie Wolff, Georg Northoff
Brain plasticity studies have shown functional reorganization in participants with outstanding motor expertise. Little is known about neural plasticity associated with exceptionally long motor training or of its predictive value for motor performance excellence. The present study utilised resting-state functional magnetic resonance imaging (rs-fMRI) in a unique sample of world-class athletes: Olympic, elite, and internationally ranked swimmers (n = 30). Their world ranking ranged from 1st to 250th: each had prepared for participation in the Olympic Games...
2017: Neural Plasticity
https://www.readbyqxmd.com/read/28257317/pulmonary-infections-in-critical-intensive-care-rapid-diagnosis-and-optimizing-antimicrobial-usage
#20
Ivor S Douglas
PURPOSE OF REVIEW: Diagnosis of pulmonary infection, including hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP) in the critically ill patient remains a common and therapeutically challenging diagnosis with significant attributable morbidity, mortality, and cost. Current clinical approaches to surveillance, early detection and, conventional culture-based microbiology are inadequate for optimal targeted antibiotic treatment and stewardship. Efforts to enhance diagnosis of HAP and VAP and the impact of these novel approaches on rational antimicrobial selection and stewardship are the focus of recent studies reviewed here...
March 2, 2017: Current Opinion in Pulmonary Medicine
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