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Guo-Liang Shao, Jia-Ping Zheng, Li-Wen Guo, Yu-Tang Chen, Hui Zeng, Zheng Yao
BACKGROUND: The purpose of this study is to evaluate the efficacy of transcatheter arterial chemoembolization (TACE) combined with computed tomography-guided radiofrequency ablation (CT-RFA) in the treatment of hepatocellular carcinoma (HCC) using magnetic resonance diffusion weighted imaging (MR-DWI) and CT perfusion imaging (CT-PI). METHODS: From January 2008 to January 2014, a total of 522 HCC patients receiving TACE combined with CT-RFA were included in this study...
January 2017: Medicine (Baltimore)
Hui Zhu, Dagang Guo, Wenli Qi, Kewei Xu
To follow the design strategy of traditional biphasic calcium phosphate (BCP) ceramic, in the present study, strontium-doped biphasic calcium phosphate bone cement (Sr-BCPC) composites comprising Sr-β-tricalcium phosphate (TCP)/Sr-hydroxyapatite (HAP) had been prepared for the first time using Sr x -β-TCP/tetracalcium phosphate (TTCP) as a cement powder and diluted phosphoric acid as a cement liquid. The phase composition, setting time, compressive strength, washout resistance, in vitro degradation rate, microstructure evolutions, hydration dynamics and cytotoxicity of Sr-BCPC at various Sr contents were intensively investigated...
January 17, 2017: Biomedical Materials
Sebastien Boucle, Xiao Lu, Leda Bassit, Tugba Ozturk, Olivia Ollinger Russell, Franck Amblard, Steven J Coats, Raymond F Schinazi
New modifications to the scaffold of previously reported HBV capsid assembly effectors such as BAY 41-4109, HAP-12 and GLS4 were explored. The anti-HBV activity in the HepAD38 system, and cytotoxicity profiles of each of the new compounds has been assessed. Among them, five new iodo- and bromo-heteroarylpyrimidines analogs displayed anti-HBV activity in the low micromolar range.
January 6, 2017: Bioorganic & Medicinal Chemistry Letters
Donee Alexander, Amanda Northcross, Nathaniel Wilson, Anindita Dutta, Rishi Pandya, Tope Ibigbami, Damilola Adu, John Olamijulo, Oludare Morhason-Bello, Theodore Karrison, Oladosu Ojengbede, Christopher O Olopade
RATIONALE: Hypertension during pregnancy is a leading cause of maternal mortality. Exposure to household air pollution (HAP) elevates blood pressure (BP). OBJECTIVES: Investigate ability of clean cookstove intervention to lower BP during pregnancy. METHODS: A randomized, controlled trial (RCT) was conducted in Nigeria. Pregnant women cooking with kerosene or firewood were randomly assigned to ethanol (n = 162) or control arms (n = 162). BP measurements were taken during 6 antenatal visits...
January 12, 2017: American Journal of Respiratory and Critical Care Medicine
Haorong Wang, Zuohui Xiao, Jie Yang, Danyang Lu, Anil Kishen, Yanqiu Li, Zhen Chen, Kehua Que, Qian Zhang, Xuliang Deng, Xiaoping Yang, Qing Cai, Ning Chen, Changhong Cong, Binbin Guan, Ting Li, Xu Zhang
Achieving oriented and ordered remineralization on the surface of demineralized dental enamel, thereby restoring the satisfactory mechanical properties approaching those of sound enamel, is still a challenge for dentists. To mimic the natural biomineralization approach for enamel remineralization, the biological process of enamel development proteins, such as amelogenin, was simulated in this study. In this work, carboxymethyl chitosan (CMC) conjugated with alendronate (ALN) was applied to stabilize amorphous calcium phosphate (ACP) to form CMC/ACP nanoparticles...
January 12, 2017: Scientific Reports
S A Grant, S E Smith, H Schmidt, F Pfeiffer, K Kuroki, S Sherman, R A White, D A Grant
Acellular human gracilis tendons conjugated with gold nanoparticles (AuNP) and hydroxyapatite nanoparticles (nano-HAp) were used as a graft in an anterior cruciate ligament (ACL) reconstruction rabbit model. The ACLs of 11 New Zealand rabbits were reconstructed using grafts conjugated without nanoparticles, with AuNP only, and with both AuNP and nano-HAp. Semi-quantitative histological scoring of bone tunnel portion of grafts was performed after 14 weeks. Bone tunnels were scored for graft degeneration, graft remodeling, percentage of new host fibrous connective, collateral connection, head-to-head connection, graft collagen fiber organization, new host fibrous connective tissue organization, and graft and interface vascularity...
January 11, 2017: Journal of Biomedical Materials Research. Part A
Weilin Yu, Tuan-Wei Sun, Chao Qi, Zhen-Yu Ding, Hua-Kun Zhao, Feng Chen, Dao-Yun Chen, Ying-Jie Zhu, Zhongmin Shi, Yaohua He
Nanostructured calcium phosphate (CaP) porous microspheres are of great potential in drug delivery and bone regeneration due to their large specific surface area, biocompatibility and similarity to inorganic component of osseous tissue. In this work, strontium (Sr)-doped amorphous calcium phosphate porous microspheres (SrAPMs) were synthesized through a microwave-hydrothermal method using fructose 1,6-bisphosphate trisodium salt (FBP) as the source of phosphate ions. The SrAPMs showed a mesoporous structure and a relatively high specific area...
January 10, 2017: ACS Applied Materials & Interfaces
Yudong Yin, Peter Hountras, Richard G Wunderink
PURPOSE OF REVIEW: Discovery of a normal lung microbiome requires reassessment of our concepts of HAP/VAP pathogenesis and has important implications for clinical diagnosis and management. RECENT FINDINGS: Changes in the microbiome of dental plaque are associated with increased risk of HAP/VAP. A transition to a lung microbiome enriched with gut flora is found in ARDS with an increased inflammatory response in patients with this change in microbial flora. A characteristic microbiome pattern of higher amounts of bacterial DNA, lower community diversity, and greater relative abundance of a single species characterize pneumonia and occasionally identify bacteria not found in culture...
January 6, 2017: Current Opinion in Infectious Diseases
Stefanie Sandra Krajewski, Isabelle Isoz, Jörgen Johansson
The emerging development of antibiotic resistant bacteria calls for novel types of antibacterial agents. In this work we examined the putative antibacterial effect of purine analogs in Listeria monocytogenes We show that, among several tested purine analogs, only 6-N-hydroxylaminopurine (6-N-HAP) reduces the viability of the Gram-positive pathogen Listeria monocytogenes As in Bacillus subtilis, 6-N-HAP terminates expression at guanine riboswitches in L. monocytogenes hence preventing expression of their downstream genes...
January 6, 2017: Nucleic Acids Research
Hongliang Dai, Xiwu Lu, Yonghong Peng, Zixuan Yang, Huaqing Zhsssu
The HAP crystallization for phosphorus removal from wastewater contributes to an environmental friendly production due to the fact that it helps reduce or eliminate the water eutrophication as well as increases the recovery of mineral resources. However, the generated microcrystalline with poor settleability in high levels of supersaturation solution has a negative effect on the phosphorus recovery efficiency. To overcome the drawback, multiple reagent feed ports (four feed ports) and different recirculation ratio (1...
January 4, 2017: Environmental Science and Pollution Research International
G Anovazzi, M C Medeiros, S C Pigossi, L S Finoti, T M Souza Moreira, M P A Mayer, C F Zanelli, S R Valentini, C Rossa-Junior, R M Scarel-Caminaga
Cytokines expression can be influenced by polymorphisms in their respective coding genes. We associated the CTI/TTD haplotype (Hap-1) and TCI/CCI haplotype (Hap-2) in the IL4 gene formed by the -590, +33 and variable number of tandem repeat polymorphisms with the severity of chronic periodontitis in humans. The functionality of these IL4 haplotypes in the response of immune cells to phorbol 12-myristate 13-acetate (PMA) with Ionomycin and IL-1β (as inflammatory stimuli) was evaluated. Gene expression (quantitative real-time PCR), profile of secreted cytokines (multiplex) and phenotypic polarization of T cells (flow cytometry) were the outcomes assessed...
January 5, 2017: Genes and Immunity
Hsiu-Wen Chien, Jiashing Yu, Shing Tak Li, Hsin-Yu Chen, Wei-Bor Tsai
Hydrogels provide three-dimensional (3D) frames with tissue-like elasticity and high water content for tissue scaffolds. Previously, we reported the design and synthesis protocol of a biodegradable poly(carboxybetaine) poly(CB) hydrogel with a zwitterionic carboxybetaine methacrylate (CBMA) monomer and a disulfide-containing crosslinker via free radical polymerization. We also demonstrated that cells could be successfully encapsulated in the hydrogels without compromising cytoviability. In this study, we evaluated the cytoviability of three commonly used zwitterionic monomers (CBMA, 2-methacryloyloxyethyl phosphorylcholine (MPC) and sulfobetaine methacrylate (SBMA)) and the suitability of being utilized as precursor materials for in situ gel forming implants...
January 4, 2017: Biomaterials Science
Shanshan Zhu, Jiachang Wang, Maohong Cai, Huan Zhang, Fuqing Wu, Yang Xu, Chaonan Li, Zhijun Cheng, Xin Zhang, Xiuping Guo, Peike Sheng, Mingming Wu, Jiulin Wang, Cailin Lei, Jie Wang, Zhichao Zhao, Chuanyin Wu, Haiyang Wang, Jianmin Wan
Heading date is an important agronomic trait related to crop yield. Many genes related to heading date have already been identified in rice (Oryza sativa), and a complicated, preliminary regulatory genetic network has also already been established, but the protein regulatory network is poorly understood. We have identified a novel heading date regulator, Heme Activator Protein like 1 (OsHAPL1), which inhibits flowering under long-day conditions. OsHAPL1 is a nuclear-localized protein that is highly expressed in leaves in a rhythmic manner...
January 2, 2017: Journal of Experimental Botany
Caroline Ochieng, Sotiris Vardoulakis, Cathryn Tonne
Cooking with biomass fuel is an important source of household air pollution (HAP) in developing countries, and a leading risk factor for ill-health. Although various designs of "improved cookstoves" (ICS) have been promoted as HAP interventions in these settings, few of them have undergone in-field evaluation, partly due to the challenge of conducting field measurements in remote settings. In this study we assessed the change in carbon monoxide (CO) exposure following the replacement of the traditional three-stone stove with a popular ICS in 49 homes in Western Kenya...
December 28, 2016: Science of the Total Environment
Jianguo Xu, Zai-Sheng Wu, Zhenmeng Wang, Jingqing Le, Tingting Zheng, Lee Jia
Facile assembly of intelligent DNA nanoobjects with the ability to exert in situ visualization of intracellular microRNAs (miRNAs) has long been concerned in the fields of DNA nanotechnology and basic medical study. Here, we present a driving primer (DP)-triggered polymerization-mediated metastable assembly (PMA) strategy to prepare a well-ordered metastable DNA nanoarchitecture composed of only two hairpin probes (HAPs), which has never been explored by assembly methods. Its structural features and functions are characterized by atomic force microscope (AFM) and gel electrophoresis...
December 22, 2016: Biomaterials
Drayton A Hammond, Claire E Vines, Ashley L McPhee, Naleen Raj Bhandari, Kendrea M Jones, Nikhil Meena, Jacob T Painter
PURPOSE: To determine whether etomidate use before intubation increased development of hospital-acquired pneumonia (HAP) in critically ill, nontrauma patients. MATERIALS AND METHODS: A single-center, retrospective, cohort study of critically ill, nontrauma patients admitted to the medical intensive care unit (ICU) from 2012 to 2015 and intubated with or without etomidate was conducted. Demographics, comorbidities, primary diagnosis, critical illness scores, concomitant medications, and outcomes were obtained from medical records...
January 1, 2016: Journal of Intensive Care Medicine
Lu Zhang, Hongmei Luo, Geping Kang, Wenxia Wang, Yalan Hu
The aim of this study was to assess whether physical activity can predict mortality in patients undergoing maintenance hemodialysis (MHD). This observational study enrolled 317 patients undergoing MHD from Shanxi Provincial People Hospital and the Second Affiliated Hospital of Xi'an Medical University from February to June 2012. Physical activity was measured by using the Human Activity Profile (HAP) and the Stanford 7-day Physical Activity Recall Questionnaire (PAR). Exercise or not, maximal activity score (MAS), adjusted activity score (AAS), light physical activities, moderate physical activities, and the PAR value were significantly associated with mortality among patients undergoing MHD...
December 27, 2016: International Journal of Nursing Practice
D Sidane, H Rammal, A Beljebbar, S C Gangloff, D Chicot, F Velard, H Khireddine, A Montagne, H Kerdjoudj
Titania-Hydroxyapatite (TiO2/HAP) reinforced coatings are proposed to enhance the bioactivity and corrosion resistance of 316L stainless steel (316L SS). Herein, spin- and dip-coating sol-gel processes were investigated to construct two kinds of coatings: TiO2/HAP composite and TiO2/HAP bilayer. Physicochemical characterization highlighted the bioactivity response of the TiO2/HAP composite once incubated in physiological conditions for 7days whereas the TiO2/HAP bilayer showed instability and dissolution. Biological analysis revealed a failure in human stem cells adhesion on TiO2/HAP bilayer whereas on TiO2/HAP composite the presence of polygonal shaped cells, possessing good behaviour attested a good biocompatibility of the composite coating...
March 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
Maria Alejandra Castilla Bolaños, Josef Buttigieg, Juan Carlos Briceño Triana
The fabricated small intestine submucosa (SIS) - hydroxyapatite (HAp) sponges can act as biomimetic scaffolds to be utilized in tissue engineering and regeneration. Here we developed SIS-HAp sponges and investigated their mechanical, physical and chemical characteristics using scanning electron microscopy, Fourier transformed infrared spectroscopy, uniaxial compression, porosity, and swelling testing techniques. The results demonstrated mechanical properties superior to comparable bone substitutes fabricated with similar methods...
March 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
I S Yahia, Mohd Shkir, S AlFaify, V Ganesh, H Y Zahran, Mona Kilany
In this work, the authors have fabricated the nanorods and nanosheets of pure and Te-doped HAp with different Te concentrations (0.04, 0.08, 0.16, 0.24wt%) by microwave-assisted technique at low temperature. The crystallite size, degree of crystallinity and lattice parameters are calculated. FE-SEM study confirms that the fabricated nanostructures are nanorods of diameter about 10nm in undoped and at low concentration of Te doping. However, at and higher concentration, it becomes nanosheets of about 5nm thickness...
March 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
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