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https://www.readbyqxmd.com/read/28722515/construction-of-a-plga-based-targeted-sirna-delivery-system-for-treatment-of-osteoporosis
#1
Deniz Sezlev Bilecen, Jose Carlos Rodriguez-Cabello, Hasan Uludag, Vasif Hasirci
Osteoporosis is a systemic skeletal disorder which occurs when the bone turnover balance is disrupted. With the identification of the genes involved in the pathogenesis of the disease, studies on development of new osteoporosis treatments has intensified. RNA interference (RNAi) mechanism uses short interfering RNA (siRNA) to knockdown disease related gene expression as a treatment approach. Targeting while protecting siRNA against hydrolysis by nucleases in vivo is, however, challenging. The maintenance of therapeutic plasma level is also hampered by the clearance of siRNA from the body...
July 19, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28721903/clinical-advances-of-hypoxia-activated-prodrugs-in-combination-with-radiation-therapy
#2
REVIEW
Ishna N Mistry, Matthew Thomas, Ewen D D Calder, Stuart J Conway, Ester M Hammond
With the increasing incidence of cancer worldwide, the need for specific, effective therapies is ever more urgent. One example of targeted cancer therapeutics is hypoxia-activated prodrugs (HAPs), also known as bioreductive prodrugs. These prodrugs are inactive in cells with normal oxygen levels but in hypoxic cells (with low oxygen levels) undergo chemical reduction to the active compound. Hypoxia is a common feature of solid tumors and is associated with a more aggressive phenotype and resistance to all modes of therapy...
August 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28705021/atorvastatin-loaded-micelles-with-bone-targeted-ligand-for-the-treatment-of-osteoporosis
#3
Yonghui Xie, Xueying Tan, Jian Huang, Hongwei Huang, Ping Zou, Jingbo Hu
Osteoporosis is a common bone disorder where the declined bone mass is far more than normal physiological status and usually associated with enhanced fracture risk, reduced bone strength and even deteriorated quality of life. Recent studies showed that statins could exert beneficial effects on bones via promoting osteoblastic activity mediated by increased expression of bone morphogenetic protein 2 and also by suppressing osteoclast proliferation. In this study, we developed atorvastatin-loaded tetracycline-poly (ethylene glycol)-poly(lactic-co-glycolic acid) (TC-PEG-PLGA/ATO) micelles for the targeted treatment of osteoporosis...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28703259/-evaluation-of-referral-and-intervention-patterns-at-the-psychiatric-emergency-service-utrecht-2009-2015
#4
M H Hoek, A W Braam
Emergency psychiatric care in the Netherlands is provided mainly by community mental health services. Although these emergency services vary in their approach per region, they show many similarities: they tend to receive referrals from the same type of agencies and they practice similar techniques of crisis management.<br/> AIM: To identify some of the patterns that appear in the type of psychiatric problems encountered, the type of referral agencies involved and in the intervention strategies practiced by the psychiatric emergency service in Utrecht...
2017: Tijdschrift Voor Psychiatrie
https://www.readbyqxmd.com/read/28683135/spike-patterning-in-oxytocin-neurons-capturing-physiological-behaviour-with-hodgkin-huxley-and-integrate-and-fire-models
#5
Trystan Leng, Gareth Leng, Duncan J MacGregor
Integrate-and-fire (IF) models can provide close matches to the discharge activity of neurons, but do they oversimplify the biophysical properties of the neurons? A single compartment Hodgkin-Huxley (HH) model of the oxytocin neuron has previously been developed, incorporating biophysical measurements of channel properties obtained in vitro. A simpler modified integrate-and-fire model has also been developed, which can match well the characteristic spike patterning of oxytocin neurons as observed in vivo. Here, we extended the HH model to incorporate synaptic input, to enable us to compare spike activity in the model with experimental data obtained in vivo...
2017: PloS One
https://www.readbyqxmd.com/read/28681967/augmentation-of-fracture-healing-by-hydroxyapatite-collagen-paste-and-bone-morphogenetic-protein-2-evaluated-using-a-rat-femur-osteotomy-model
#6
Xuetao Wei, Satoru Egawa, Renpei Matsumoto, Hiroaki Yasuda, Keigo Hirai, Toshitaka Yoshii, Atsushi Okawa, Takehiko Nakajima, Shinichi Sotome
In fracture treatment, biological bone union generally depends on the bone's natural fracture healing capacity, even in surgically treated cases. Hydroxyapatite/collagen composite (HAp/Col) has high osteoconductivity and stimulates osteogenic progenitors. Furthermore, it has the potent capacity to adsorb bone morphogenetic proteins (BMPs). In this study, we prepared an injectable HAp/Col paste and evaluated its augmentation of bone union. Furthermore, the effect of HAp/Col paste combined with BMP-2 was also evaluated...
July 6, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28677837/determination-of-tigecycline-in-human-plasma-by-lc-ms-ms-and-its-application-to-population-pharmacokinetics-study-in-chinese-patients-with-hospital-acquired-pneumonia
#7
Rong Shao, Xingang Li, Yangmin Hu, Jinliang Chen, Honggang Lou, Haibin Dai
A selective, sensitive, and rapid liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the determination of Tigecycline (TGC) in human plasma, using Tigecycline-d9 as an internal standard (IS). Analytical samples were prepared using a protein precipitation method coupled with a concentration process. The analyte and IS were separated on a reversed-phase Waters Acquity UPLC® BEH-C18 column (2.1 mm × 50 mm ID, 1.7 μm) with a flow rate of 0.25 ml/min. The mobile phase consisted of water, containing 0...
July 5, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28671150/emerging-trends-of-nosocomial-pneumonia-in-intensive-care-unit-of-a-tertiary-care-public-teaching-hospital-in-western-india
#8
Rakesh Bhadade, Minal Harde, Rosemarie deSouza, Ashwini More, Ramesh Bharmal
BACKGROUND: Nosocomial pneumonia poses great challenge to an intensivist. Detailed information about hospital-acquired pneumonia (HAP) and ventilator-acquired pneumonia (VAP) is crucial for prevention and optimal management, thus improving quality Intensive Care Unit (ICU) care. Hence, we aimed to study the current trend of nosocomial pneumonia in ICU. MATERIALS AND METHODS: It was a prospective observational cohort study, conducted in the ICU of a tertiary care teaching public hospital over a period of 18 months...
July 2017: Annals of African Medicine
https://www.readbyqxmd.com/read/28670447/short-term-hypoxic-preconditioning-promotes-prevascularization-in-3d-bioprinted-bone-constructs-with-stromal-vascular-fraction-derived-cells
#9
Mitchell A Kuss, Robert Harms, Shaohua Wu, Ying Wang, Jason B Untrauer, Mark A Carlson, Bin Duan
Reconstruction of complex, craniofacial bone defects often requires autogenous vascularized bone grafts, and still remains a challenge today. In order to address this issue, we isolated the stromal vascular fraction (SVF) from adipose tissues and maintained the phenotypes and the growth of endothelial lineage cells within SVF derived cells (SVFC) by incorporating an endothelial cell medium. We 3D bioprinted SVFC within our hydrogel bioinks and conditioned the constructs in either normoxia or hypoxia. We found that short-term hypoxic conditioning promoted vascularization-related gene expression, whereas long-term hypoxia impaired cell viability and vascularization...
June 5, 2017: RSC Advances
https://www.readbyqxmd.com/read/28664910/corrigendum-engineering-the-residual-side-chains-of-hap-phytases-to-improve-their-pepsin-resistance-and-catalytic-efficiency
#10
Canfang Niu, Peilong Yang, Huiying Luo, Huoqing Huang, Yaru Wang, Bin Yao
This corrects the article DOI: 10.1038/srep42133.
June 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28655326/treatment-of-severe-hospital-acquired-and-ventilator-associated-pneumonia-a-systematic-review-of-inclusion-and-judgment-criteria-used-in-randomized-controlled-trials
#11
Emmanuel Weiss, Wafa Essaied, Christophe Adrie, Jean-Ralph Zahar, Jean-François Timsit
BACKGROUND: Hospital-acquired and ventilator-associated pneumonia (HAP/VAP) are often selected for randomized clinical trials (RCTs) aiming at new drug approval. Guidelines for the design of such RCTs have been repeatedly updated by regulatory agencies. We hypothesized that large variability in the enrolled populations, the endpoints assessed and the HAP/VAP definition criteria may impact the results of these studies, and addressed this through a systematic review of HAP/VAP RCTs. METHODS: A search (Pubmed-Embase-ICAAC-ECCMID) of all RCTs published between 1994 and 2016 comparing antimicrobial treatment for HAP/VAP in the intensive care unit was conducted...
June 27, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/28652926/silk-fibroin-hydroxyapatite-composite-hydrogel-induced-by-gamma-ray-irradiation-for-bone-tissue-engineering
#12
Min Hee Kim, Beom Su Kim, Jun Lee, Donghwan Cho, Oh Hyeong Kwon, Won Ho Park
BACKGROUND: In this study, silk fibroin (SF) composite hydrogels containing hydroxyapatite (HAP) nanoparticles (NPs) for bone tissue engineering were fabricated using gamma-ray (γ-ray) irradiation treatment. During the irradiation, the HAP dispersed SF solution was changed to the chemically crosslinked SF hydrogel. METHODS: Distribution of HAP NPs in the SF hydrogel was examined by SEM imagery and energy dispersive X-ray spectrophotometry, and the crystalline structure of SF composite hydrogels was also confirmed by X-ray diffractometry...
2017: Biomaterials Research
https://www.readbyqxmd.com/read/28652661/observation-of-the-effect-of-targeted-therapy-of-64-slice-spiral-ct-combined-with-cryoablation-for-liver-cancer
#13
Qiao-Huan Yan, Dian-Guo Xu, Yan-Feng Shen, Ding-Ling Yuan, Jun-Hui Bao, Hai-Bin Li, Ying-Gang Lv
AIM: To observe the effect of targeted therapy with 64-slice spiral computed tomography (CT) combined with cryoablation for liver cancer. METHODS: A total of 124 patients (142 tumors) were enrolled into this study. According to the use of dual-slice spiral CT or 64-slice spiral CT as a guide technology, patients were divided into two groups: dual-slice group (n = 56, 65 tumors) and 64-slice group (n = 8, 77 tumors). All patients were accepted and received targeted therapy by an argon-helium superconducting surgery system...
June 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28639437/ultrasound-assisted-green-economic-synthesis-of-hydroxyapatite-nanoparticles-using-eggshell-bio-waste-and-study-of-mechanical-and-biological-properties-for-orthopaedic-applications
#14
Vijay H Ingole, Kamal Hany Hussein, Anil A Kashale, Kalyani Ghule, Tomaž Vuherer, Vanja Kokol, Jia-Yaw Chang, Yong-Chien Ling, Aruna Vinchurkar, Hom N Dhakal, Anil V Ghule
Nanostructured hydroxyapatite (HAp) is most favorable candidate biomaterial for bone tissue engineering because of its bioactive and osteoconductive properties. Herein, we report for the first time ultrasound assisted facile and economic approach for the synthesis of nanocrystalline hydroxyapatite (Ca10 (PO4 )6 (OH)2 ) using recycled eggshell bio-waste referred as EHAp. The process involves the reaction of eggshell bio-waste as a source of calcium and ammonium dihydrogen orthophosphate as a phosphate source...
June 22, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28629478/genetic-epigenetic-interactions-in-cis-a-major-focus-in-the-post-gwas-era
#15
REVIEW
Catherine Do, Alyssa Shearer, Masako Suzuki, Mary Beth Terry, Joel Gelernter, John M Greally, Benjamin Tycko
Studies on genetic-epigenetic interactions, including the mapping of methylation quantitative trait loci (mQTLs) and haplotype-dependent allele-specific DNA methylation (hap-ASM), have become a major focus in the post-genome-wide-association-study (GWAS) era. Such maps can nominate regulatory sequence variants that underlie GWAS signals for common diseases, ranging from neuropsychiatric disorders to cancers. Conversely, mQTLs need to be filtered out when searching for non-genetic effects in epigenome-wide association studies (EWAS)...
June 19, 2017: Genome Biology
https://www.readbyqxmd.com/read/28629095/solvothermal-synthesis-of-hydroxyapatite-nanorods-with-assistance-of-green-polymer
#16
Hui Yang, Tongxiang Liang, Xiaopeng Qi, Honghui Jiang, Yiqun Deng, Ping Wang, Huichang Gao
Development of low cost, environmental friendly crystal growth modifying reagents that are effective to HAp's microstructure regulation is highly crucial. Herein, sodium lignin sulfonate (SS), a byproduct of the pulp process, was used for preparing HAp nanorods. Results showed that both stirring time of reaction solution and the concentration of SS affected crystals' structure and aspect ratio. The growth mechanism was discussed on the basis of the results. And we hope this new synthetic strategy will offer an attractive route for the design of functional HAp nano-/micro- materials with fine structure...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28629092/binary-functional-porous-multi-mineral-substituted-apatite-nanoparticles-for-reducing-osteosarcoma-colonization-and-enhancing-osteoblast-cell-proliferation
#17
Dharman Govindaraj, Chandramohan Govindasamy, Mariappan Rajan
We investigated the use of combined nanoparticles in bone replacement for patients with bone cancer. Bismuth (Bi) is known to have antitumor effects, and the inclusion of Bi in bioactive mineral (M)-substituted hydroxyapatite (M-HAP) may provide anti-cancer properties implant resources. A series of Bi-substituted M-HAP (Bi-M-HAP) nanoparticles with various Bi concentrations was synthesized via the ultrasound irradiation method. The nanoparticles were examined using physicochemical strategies. The cell-substance interface of the nanoparticles was observed in vitro with human osteosarcoma cells and cell multiplication was measured at 1, 3, and 7days of incubation and in vivo in rats after 3weeks of implantation...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28629016/effect-of-stearic-acid-modified-hap-nanoparticles-in-different-solvents-on-the-properties-of-pickering-emulsions-and-hap-plla-composites
#18
Ming Zhang, Ai-Juan Wang, Jun-Ming Li, Na Song
Stearic acid (Sa) was used to modify the surface properties of hydroxyapatite (HAp) in different solvents (water, ethanol or dichloromethane(CH2Cl2)). Effect of different solvents on the properties of HAp particles (activation ratio, grafting ratio, chemical properties), emulsion properties (emulsion stability, emulsion type, droplet morphology) as well as the cured materials (morphology, average pore size) were studied. FT-IR and XPS results confirmed the interaction occurred between stearic acid and HAp particles...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28626286/synergistic-effect-of-fluoride-and-laser-irradiation-for-the-inhibition-of-the-demineralization-of-dental-enamel
#19
Raymond Lee, Kenneth H Chan, Jamison Jew, Jacob C Simon, Daniel Fried
Both laser irradiation and fluoride treatment alone are known to provide increased resistance to acid dissolution. CO2 lasers tuned to a wavelength of 9.3 μm can be used to efficiently convert the carbonated hydroxyapatite of enamel to a much more acid resistant purer phase hydroxyapatite (HAP). Further studies have shown that fluoride application to HAP yields fluoroapatite (FAP) which is even more resistant against acid dissolution. Previous studies show that CO2 lasers and fluoride treatments interact synergistically to provide significantly higher protection than either method alone, but the mechanism of interaction has not been elucidated...
January 28, 2017: Proceedings of SPIE
https://www.readbyqxmd.com/read/28624864/the-clinical-significance-of-pneumonia-in-patients-with-respiratory-specimens-harbouring-multidrug-resistant-pseudomonas-aeruginosa-a-5-year-retrospective-study-following-5667-patients-in-four-general-icus
#20
B Borgatta, S Gattarello, C A Mazo, A T Imbiscuso, M N Larrosa, M Lujàn, J Rello
Pseudomonas aeruginosa is the leading cause of pneumonia in intensive care units (ICUs), with multidrug-resistant (MDR) strains posing a serious threat. The aim of this study was to assess the clinical relevance of MDR Pseudomonas isolates in respiratory clinical specimens. A 5-year retrospective observational study in four medical-surgical ICUs from a referral hospital was carried out. Of 5667 adults admitted to the ICU, 69 had MDR-PA in respiratory samples: 31 were identified as having pneumonia (HAP/VAP): 21 ventilator-associated pneumonia (VAP) and ten hospital-acquired pneumonia (HAP)...
June 17, 2017: European Journal of Clinical Microbiology & Infectious Diseases
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