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https://www.readbyqxmd.com/read/29341032/-epidemiology-diagnosis-and-treatment-of-adult-patients-with-nosocomial-pneumonia-update-2017-s3-guideline-of-the-german-society-for-anaesthesiology-and-intensive-care-medicine-the-german-society-for-infectious-diseases-the-german-society-for-hygiene-and-microbiology
#1
K Dalhoff, M Abele-Horn, S Andreas, M Deja, S Ewig, P Gastmeier, S Gatermann, H Gerlach, B Grabein, C P Heußel, G Höffken, M Kolditz, E Kramme, H Kühl, C Lange, K Mayer, I Nachtigall, M Panning, M Pletz, P-M Rath, G Rohde, S Rosseau, B Schaaf, D Schreiter, H Schütte, H Seifert, C Spies, T Welte
Nosocomial pneumonia (HAP) is a frequent complication of hospital care. Most data are available on ventilator-associated pneumonia. However, infections on general wards are increasing. A central issue are infections with multidrug resistant (MDR) pathogens which are difficult to treat in the empirical setting potentially leading to inappropriate use of antimicrobial therapy.This guideline update was compiled by an interdisciplinary group on the basis of a systematic literature review. Recommendations are made according to GRADE giving guidance for the diagnosis and treatment of HAP on the basis of quality of evidence and benefit/risk ratio...
January 2018: Pneumologie
https://www.readbyqxmd.com/read/29334905/efficacy-comparison-of-multi-phase-ct-and-hepatotropic-contrast-enhanced-mri-in-the-differential-diagnosis-of-focal-nodular-hyperplasia-a-prospective-cohort-study
#2
Tomasz K Nowicki, Karolina Markiet, Ewa Izycka-Swieszewska, Katarzyna Dziadziuszko, Michal Studniarek, Edyta Szurowska
BACKGROUND: Different clinical behaviour influences the importance of differentiating focal nodular hyperplasia (FNH) from other focal liver lesions (FLLs). The aim of this study was to compare the efficacy of contrast-enhanced CT and MRI in the diagnosis of FNH. METHODS: 157 patients with equivocal FLLs detected in ultrasonography subsequently underwent multi-phase CT and MRI with the use of hepatotropic contrast agent (Gd-BOPTA) in a 1.5 T scanner. Examinations were evaluated by three independent readers...
January 15, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29321868/global-mtdna-genetic-structure-and-hypothesized-invasion-history-of-a-major-pest-of-citrus-diaphorina-citri-hemiptera-liviidae
#3
Yufa Luo, Ingi Agnarsson
The Asian citrus psyllid Diaphorina citri Kuwayama is a key pest of citrus as the vector of the bacterium causing the "huanglongbing" disease (HLB). To assess the global mtDNA population genetic structure, and possible dispersal history of the pest, we investigated genetic variation at the COI gene collating newly collected samples with all previously published data. Our dataset consists of 356 colonies from 106 geographic sites worldwide. High haplotype diversity (H-mean = 0.702 ± 0.017), low nucleotide diversity (π-mean = 0...
January 2018: Ecology and Evolution
https://www.readbyqxmd.com/read/29320996/healthy-apple-program-to-support-child-care-centers-to-alter-nutrition-and-physical-activity-practices-and-improve-child-weight-a-cluster-randomized-trial
#4
Jodi D Stookey, Jane Evans, Curtis Chan, Lisa Tao-Lew, Tito Arana, Susan Arthur
BACKGROUND: North Carolina Nutrition and Physical Activity Self-Assessment for Child Care (NAP SACC) resources improve child body mass index (BMI) when the resources are introduced by nurses to child care providers, and offered with workshops and incentives. In San Francisco, public health and child care agencies partnered to adapt NAP SACC resources into an annual "Healthy Apple" quality improvement program (HAP). METHODS: This cluster randomized controlled trial pilot-tested integration of the HAP with bi-annual public health screenings by nurses...
December 19, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29318781/phosphonate-functionalized-poly-%C3%AE-amino-ester-macromers-as-potential-biomaterials
#5
Ece Akyol, Mirac Tatliyuz, Fatma Demir Duman, Melek Naz Guven, Havva Yagci Acar, Duygu Avci
Biodegradability, hemocompatibility, resistance to protein adsorption, and strong interactions with hydroxyapatite (HAP)-based tissues such as dentin, enamel, and bone are important properties of phosphorus-containing biomaterials. Here, novel phosphonate-functionalized poly(β-amino ester) (PBAE) macromers are synthesized through aza-Michael addition of various diacrylates [1,6-hexanediol diacrylate (HDDA), poly(ethylene glycol) diacrylate (PEGDA, Mn =575), 1,4-butanediol diacrylate (BDDA), 1,6-hexanediol ethoxylate diacrylate (HDEDA) and triethylene glycol diacrylate (TEGDA)] and a phosphonate-containing primary amine (diethyl 2-aminoethylphosphonate, A1) efficiently without any catalyst; where replacement of A1 with propyl amine (PA) served as control...
January 10, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29317824/selection-of-piperacillin-tazobactam-infusion-mode-guided-by-sofa-score-in-cancer-patients-with-hospital-acquired-pneumonia-a-randomized-controlled-study
#6
Yang Lyu, Yang Yang, Xin Li, Min Peng, Xin He, Peng Zhang, Shangwen Dong, Wanhua Wang, Donghao Wang
Background: This study aimed to select piperacillin/tazobactam (TZP) infusion mode guided by Sequential Organ Failure Assessment (SOFA) score in cancer patients with hospital-acquired pneumonia (HAP) postoperation. Patients and methods: A total of 120 cancer patients with postoperative HAP were divided into two groups: improved administration group (L group) and conventional treatment group (Con group). The Con group received traditional infusion of TZP and the L group received it as prolonged infusion...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29316830/use-of-monte-carlo-simulation-to-evaluate-the-efficacy-of-tigecycline-and-minocycline-for-the-treatment-of-pneumonia-due-to-carbapenemase-producing-klebsiella-pneumoniae
#7
Wentao Ni, Guobao Li, Jin Zhao, Junchang Cui, Rui Wang, Zhancheng Gao, Youning Liu
BACKGROUND: Pneumonia caused by carbapenemase-producing Klebsiella pneumoniae (CP-KP) are increasingly encountered in hospitals worldwide, causing high mortality due to lack of treatment options. The goal of this study was to assess the efficacy of tigecycline and minocycline for CP-KP hospital-acquired pneumonia (HAP) by using Monte Carlo simulation. METHODS: A total of 164 non-duplicated CP-KP strains were collected from sputum or blood in patients with HAP. The MICs for antimicrobials were determined by the agar dilution method...
January 9, 2018: Infectious Diseases
https://www.readbyqxmd.com/read/29314671/different-compact-hybrid-langmuir-blodgett-film-coatings-modify-biomineralization-and-the-ability-of-osteoblasts-to-grow
#8
Amanda N de Faria, Marcos A E Cruz, Gília C M Ruiz, Daniela C Zancanela, Pietro Ciancaglini, Ana P Ramos
Calcium phosphates (CaPs) are biomaterials widely used in tissue regeneration with outstanding biological performance. Although the tremendous improvements achieved in CaP's materials research over the years, their interaction with physiological environments still need to be fully understood. The aim of this study is to explore a biomimetic Langmuir-Blodgett (LB) membrane to template the growth of hydroxyapatite (HAp) coatings on Ti surfaces and the ability of these coatings in inducing biomineralization by osteoblasts cultured in vitro...
January 4, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29309148/identification-of-factors-promoting-hbv-capsid-self-assembly-by-assembly-promoting-antivirals
#9
Soumya Lipsa Rath, Huihui Liu, Susumu Okazaki, Wataru Shinoda
Around 270 million individuals currently live with Hepatitis B Virus (HBV) infection. Heteroaryldihydropyrimidines (HAPs) are a family of antivirals that target the HBV capsid protein and induce aberrant self-assembly. The capsids formed resemble the native capsid structure, but are unable to propagate the virus progeny due to lack of RNA/DNA. Under normal conditions, self-assembly is initiated by the viral genome. The mode of action of HAPs, however, remains largely unknown. Here, using molecular dynamics simulations, we attempted to understand HAP action by comparing the dynamics of capsid proteins with and without HAPs...
January 8, 2018: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/29308753/-design-and-application-of-bundle-treatment-plan-in-the-early-stage-for-severe-human-infection-by-avian-influenza-h7n9
#10
Ling Wang, Xiaobin Fang, Yongling Yang, Zhengping Zhang, Jianlin Zhou, Jingsong Yang, Kaifeng Liu, Zhenhua Wang
OBJECTIVE: To design bundle treatment plan in the early stage for severe human infection by avian influenza H7N9, and explore its clinical efficacy and application value. METHODS: Fifteen patients with severe human infection by avian influenza H7N9 in Guizhou Province from December 29th, 2016 to June 7th, 2017 were enrolled. Patients admitted from March 6th, 2017 to June 7th, 2017 served as a prospective observation period (bundle treatment group), and those from December 29th, 2016 to March 5th, 2017 were selected as a historical control period (conventional treatment group)...
January 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29303279/-hospital-acquired-pneumonias
#11
Petr Jakubec, Aneta Křenková, Vítězslav Kolek
Nosocomial infections are a common complication of hospital care. Hospital-acquired (HAP) pneumonia is one of the most common nosocomial infections and it is the most dangerous in terms of mortality. The problem is mainly selected hospital bacterial strains with rising antibiotic resistance. Diagnosis of the cause of pneumonia is difficult and often does not lead to a positive result. Management is complex and is based on timely and appropriate empirical antibiotic treatment. Local and extrapulmonary complications are relatively common and they increase morbidity and mortality...
2018: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29301918/ers-ats-workshop-report-on-respiratory-health-effects-of-household-air-pollution
#12
Akshay Sood, Nour A Assad, Peter J Barnes, Andrew Churg, Stephen B Gordon, Kevin S Harrod, Hammad Irshad, Om P Kurmi, William J Martin, Paula Meek, Kevin Mortimer, Curtis W Noonan, Rogelio Perez-Padilla, Kirk R Smith, Yohannes Tesfaigzi, Tony Ward, John Balmes
Exposure to household air pollution (HAP) from solid fuel combustion affects almost half of the world population. Adverse respiratory outcomes such as respiratory infections, impaired lung growth and chronic obstructive pulmonary disease have been linked to HAP exposure. Solid fuel smoke is a heterogeneous mixture of various gases and particulates. Cell culture and animal studies with controlled exposure conditions and genetic homogeneity provide important insights into HAP mechanisms. Impaired bacterial phagocytosis in exposed human alveolar macrophages possibly mediates several HAP-related health effects...
January 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29290418/effect-of-high-intensity-perturbations-during-core-specific-sensorimotor-exercises-on-trunk-muscle-activation
#13
Juliane Mueller, Miralem Hadzic, Hendrik Mugele, Josefine Stoll, Steffen Mueller, Frank Mayer
Core-specific sensorimotor exercises are proven to enhance neuromuscular activity of the trunk. However, the influence of high-intensity perturbations on training efficiency is unclear within this context. Sixteen participants (29±2yrs; 175±8cm; 69±13kg) were prepared with a 12-lead bilateral trunk EMG. Warm-up on a dynamometer was followed by maximum voluntary isometric trunk (flex/ext) contraction (MVC). Next, participants performed four conditions for a one-legged stance with hip abduction on a stable surface (HA) repeated randomly on an unstable surface (HAP), on a stable surface with perturbation (HA+P), and on an unstable surface with perturbation (HAP+P)...
December 15, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29287001/optimal-conditions-for-absorbable-fixation-of-hydroxyapatite-ceramic-implants
#14
Yoshiaki Sakamoto, Kazuo Kishi
Synthetic hydroxyapatite (HAP) implants are common in craniofacial surgery; the major problem with HAP implants is fixation instability. An ultrasound-assisted pinned resorbable fixation system has recently been introduced. The authors hypothesized that this resorbable system could be used to fix HAP implants. The authors evaluated the optimal HAP porosity and resorbable pin using the pull-out test and microscopic analysis. Hydroxyapatite blocks were synthesized with 0% (dense type), 35% (fine pore type), and 50% (large pore type) porosity...
January 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29278810/asthma-prevalence-and-school-related-hazardous-air-pollutants-in-the-us-m%C3%A3-xico-border-area
#15
Genny Carrillo, Maria J Perez Patron, Natalie Johnson, Yan Zhong, Rose Lucio, Xiaohui Xu
BACKGROUND: Asthma is the most common chronic disease in children and has been linked to high levels of ambient air pollution and certain hazardous air pollutants (HAPs). Outdoor pollutants such as benzene, released by car emissions, and organic chemicals found in diesel exhaust, as well as particles and irritant gases, including nitrogen dioxide (NO2), sulfur dioxide (SO2), and ozone (O3), contribute to an increased prevalence of respiratory diseases such as asthma. OBJECTIVES: The objectives of this study were to: 1) conduct a screening survey to identify high risk for asthma among school-age children in Hidalgo County, and, 2) study the potential health impact of school-related exposure to HAPs pertaining to asthma risk...
December 23, 2017: Environmental Research
https://www.readbyqxmd.com/read/29248854/spatial-bio-accumulation-of-pharmaceuticals-illicit-drugs-plasticisers-perfluorinated-compounds-and-metabolites-in-river-sediment-aquatic-plants-and-benthic-organisms
#16
John L Wilkinson, Peter S Hooda, Julian Swinden, James Barker, Stephen Barton
Organic contaminants such as pharmaceuticals, personal care products (PPCPs) and other emerging contaminants (ECs) are known to persist in the aquatic environment and many are indicated as endocrine, epigenetic, or other toxicants. Typically, the study of PPCPs/ECs in the aquatic environment is limited to their occurrence dissolved in river water. In this study, accumulation and spatial distribution of thirteen PPCPs/ECs were assessed in aquatic sediment (n = 23), periphyton (biofilm, n = 8), plants Callitriche sp...
December 14, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29246871/injectable-methylcellulose-hydrogel-containing-calcium-phosphate-nanoparticles-for-bone-regeneration
#17
Min Hee Kim, Beom Su Kim, Hanna Park, Jun Lee, Won Ho Park
A novel injectable methylcellulose (MC) hydrogel containing calcium phosphate nanoparticles (CaP NPs) was prepared by an in situ formation process, in which the precursor salts induced a salt-out effect in the MC solution. The thermo-sensitive properties of MC-CaP NPs composite hydrogels with different crystalline phases were characterized by rheometry, infrared spectroscopy and injectability test. The as-prepared MC hydrogels with bioactive CaP NPs had a suitable injectability at the body temperature, irrespective of the crystalline phases of CaP NPs...
December 12, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29238189/diethyl-citrate-and-sodium-citrate-reduce-the-cytotoxic-effects-of-nanosized-hydroxyapatite-crystals-on-mouse-vascular-smooth-muscle-cells
#18
Chong-Yu Zhang, Xin-Yuan Sun, Jian-Ming Ouyang, Bao-Song Gui
Objective: This study aimed to investigate the damage mechanism of nanosized hydroxyapatite (nano-HAp) on mouse aortic smooth muscle cells (MOVASs) and the injury-inhibiting effects of diethyl citrate (Et2Cit) and sodium citrate (Na3Cit) to develop new drugs that can simultaneously induce anticoagulation and inhibit vascular calcification. Methods: The change in cell viability was evaluated using a cell proliferation assay kit, and the amount of lactate dehydrogenase (LDH) released was measured using an LDH kit...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29236151/the-effects-of-hap-and-macrophage-cells-to-the-expression-of-inflammatory-factors-and-apoptosis-in-hk-2-cells-of-vitro-co-cultured-system
#19
Junchuan Yu, Yaoliang Deng, Zhiwei Tao, Weixia Liang, Xiaofeng Guan, Jihua Wu, Xin Ning, Yunlong Liu, Quan Liu, Ziqi He
This study developed an in vitro system by co-culturing HK-2 cells with different concentration of hydroxyapatite (HAP) and/or macrophage cells to simulate the internal environment of urolithiasis as far as possible, investigating the regulatory effects of macrophage cells on HAP-induced expression of relative inflammatory factors of HK-2 cells. The control group (H group) was only comprised of HK-2 cells. Experimental groups included co-culturing HK-2 cells and macrophage cells (H + M group), co-culturing HK-2 cells and HAP (H + A group), co-culturing macrophage cells and HAP (M + A group), and co-culturing HK-2 cells and macrophage cells with HAP (H + M + A group)...
December 13, 2017: Urolithiasis
https://www.readbyqxmd.com/read/29234216/recommendations-from-the-2016-guidelines-for-the-management-of-adults-with-hospital-acquired-or-ventilator-associated-pneumonia
#20
Samir T Kumar, Arsheena Yassin, Tanaya Bhowmick, Deepali Dixit
Hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP) continue to represent the most common nosocomial-associated infections, resulting in significant attributable mortality, increased length of hospital stay, and financial burden.1 The updated Infectious Diseases Society of America (IDSA) guidelines provide guidance on the diagnosis and management of nonimmunocompromised hosts with HAP and VAP.
December 2017: P & T: a Peer-reviewed Journal for Formulary Management
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