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https://www.readbyqxmd.com/read/29659357/-post-stroke-epilepsy
#1
Federico Rodríguez Lucci, Matías Alet, Sebastián F Ameriso
Stroke is the most common cause of seizures and epilepsy in population stuies of adults. Seizures occur within 24 hours of the stroke in a high percent of patients. The pathogenesis of these early-onset seizures may be related to local ion shifts and release of high levels of excitotoxic neurotransmitters in the area of ischemic injury. The risk of late-onset seizures may increase over time, an underlying permanent lesion that leads to persistent chnges in neuronal excitability appears to be responsible for late-onset seizures after stroke...
2018: Medicina
https://www.readbyqxmd.com/read/29624666/manual-dexterity-but-not-cerebral-palsy-predicts-cognitive-functioning-after-neonatal-stroke
#2
Guillaume Thébault, Sophie Martin, Denis Brouillet, Lionel Brunel, Mickaël Dinomais, Émilie Presles, Joel Fluss, Stéphane Chabrier
AIM: To disentangle the respective impacts of manual dexterity and cerebral palsy (CP) in cognitive functioning after neonatal arterial ischaemic stroke. METHOD: The population included 60 children (21 females, 39 males) with neonatal arterial ischaemic stroke but not epilepsy. The presence of CP was assessed clinically at the age of 7 years and 2 months (range 6y 11mo-7y 8mo) using the definition of the Surveillance of CP in Europe network. Standardized tests (Nine-Hole Peg Test and Box and Blocks Test) were used to quantify manual (finger and hand respectively) dexterity...
April 6, 2018: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/29619760/effect-of-statin-intensity-on-the-risk-of-epilepsy-after-ischaemic-stroke-real-world-evidence-from-population-based-health-claims
#3
Fang-Ju Lin, Hung-Wei Lin, Yunn-Fang Ho
BACKGROUND: Statins possess neuroprotective effects. However, real-world evidence supporting their utility in post-stroke epilepsy (PSE) prevention is limited. OBJECTIVE: The association between statin use, including timing of prescribing (pre-stroke vs post-stroke), type (lipophilicity, intensity of therapy) and dose intensity, and risk of developing PSE were investigated by studying Taiwanese health claims (2003-2013). METHODS: Patients with new-onset ischaemic stroke were identified...
April 4, 2018: CNS Drugs
https://www.readbyqxmd.com/read/29607916/-a-nationwide-multi-center-questionnaire-survey-on-the-management-and-treatment-of-post-stroke-seizure-and-epilepsy-in-japan
#4
Kyoko Higashida, Tomotaka Tanaka, Hiroshi Yamagami, Shinya Tomari, Kazuki Fukuma, Yoshinori Okuno, Souichirou Abe, Kazuyuki Nagatsuka, Kazunori Toyoda, Masafumi Ihara
Seizures may occur after stroke. Though the majority of clinicians are aware of this, a consensus-based treatment and management strategy for post-stroke seizures is not available because there have only been a few large-scale studies that have explored this. This study has surveyed the actual state of medical treatment for post-stroke seizure and epilepsy in Japan. We conducted a nationwide questionnaire survey of the top 500 institutions regarding the number of cerebral infarction cases between February 2015 and May 2015...
March 31, 2018: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/29605121/an-audit-of-clinical-practice-referral-patterns-and-appropriateness-of-clinical-indications-for-brain-mri-examinations-a-single-centre-study-in-ghana
#5
A D Piersson, G Nunoo, P N Gorleku
INTRODUCTION: The aim of this study was to investigate current brain MRI practice, pattern of brain MRI requests, and their appropriateness using the American College of Radiology (ACR) Appropriateness Criteria. MATERIAL AND METHODS: We used direct observation and questionnaires to obtain data concerning routine brain MRI practice. We then retrospectively analyzed (i) demographic characteristics, (ii) clinical history, and (iii) appropriateness of brain MRI requests against published criteria...
May 2018: Radiography
https://www.readbyqxmd.com/read/29599618/a-survey-of-epilepsy-related-knowledge-attitudes-and-practices-of-home-healthcare-nurses-in-the-san-in-region-of-japan
#6
Yuko Nishina, Shin-Ichi Yoshioka
Background: Comprehensive care is necessary for people with epilepsy (PWE) to lead a fulfilling life at home and in the community. The purpose of this study was to determine the epilepsy-related knowledge, attitudes and practices of home healthcare nurses (HHNs) in the San-in region of Japan. Methods: A questionnaire survey was conducted by mail of 546 HHNs working in Tottori and Shimane Prefectures. The questionnaire assessed the epilepsy-related knowledge, attitudes and practices of HHNs...
March 2018: Yonago Acta Medica
https://www.readbyqxmd.com/read/29598907/upstream-stimulating-factor-1-usf-1-gene-polymorphisms-and-the-risk-symptoms-and-outcome-of-pediatric-ischemic-stroke
#7
Anna Balcerzyk, Paweł Niemiec, Tomasz Iwanicki, Tomasz Nowak, Ilona Kopyta, Ewa Emich-Widera, Ewa Pilarska, Karolina Pienczk-Ręcławowicz, Marek Kaciński, Janusz Wendorff, Sylwia Górczyńska-Kosiorz, Władyslaw Grzeszczak, Iwona Żak
BACKGROUND: Pediatric ischemic stroke is an important cause of morbidity and mortality. As previous studies of children after stroke showed, dyslipidemias were very common in Polish and other European populations. Thus, looking for genetic factors predisposing to pediatric stroke, its symptoms, and outcome, we have analyzed 2 polymorphisms of the upstream stimulating factor 1 (USF-1) gene. MATERIALS AND METHODS: The study group consisted of 82 children with stroke, 156 parents, and 146 controls...
March 26, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29581333/reader-response-expression-of-concern-does-compensatory-hyperparathyroidism-predispose-to-ischemic-stroke-decreased-bone-mass-and-increased-bone-turnover-with-valproate-therapy-in-adults-with-epilepsy-an-alternative-to-vitamin-d-supplementation-to-prevent-fractures
#8
COMMENT
https://www.readbyqxmd.com/read/29581332/editors-note-expression-of-concern-does-compensatory-hyperparathyroidism-predispose-to-ischemic-stroke-decreased-bone-mass-and-increased-bone-turnover-with-valproate-therapy-in-adults-with-epilepsy-an-alternative-to-vitamin-d-supplementation-to-prevent-fractures
#9
COMMENT
https://www.readbyqxmd.com/read/29580905/-management-of-epilepsia-in-older
#10
Agathe Alberti, Benjamin Thomas, Cécile Marchal
Epilepsy increases in frequency with age, above 60, with consequences in terms of independence. Stroke and dementia are the most frequent etiologies. Clinical diagnostic of epileptic seizure is challenging at this age, and a clinical algorithm is proposed. Sleep EEG during one hour seems to be the most useful exam. Interictal and critical discharges can be seen during sleep in dementia ; relation between hyperexcitability and evolution of cognition has to be precised in this pathology. In a therapeutical point of view, it is necessary to bear in mind the pharmacological consequences of aging, polytherapies, and the frequency of adverse events in this age group...
March 2018: La Presse Médicale
https://www.readbyqxmd.com/read/29580558/prevalence-and-predictors-of-depression-among-patients-with-epilepsy-stroke-and-multiple-sclerosis-using-the-cleveland-clinic-knowledge-program-within-the-neurological-institute
#11
Adele C Viguera, Youran Fan, Nicolas R Thompson, Brittany Lapin, Alexander Chaitoff, Sandra D Griffith, Deborah M Miller, Lara Jehi, Irene L Katzan
BACKGROUND: Neurological conditions carry a high risk of depression. Given this risk, the Neurological Institute (NI) at Cleveland Clinic has initiated systematic screening for depression using the 9-item Patient Health Questionnaire-9 (PHQ-9) embedded within its electronic medical record and its data capture system, the Knowledge Program (KP)1 . OBJECTIVE: We sought to (1) estimate the prevalence of depression among patients with epilepsy, stroke, and multiple sclerosis (MS); (2) identify risk factors for depression within each disease; and (3) determine differential risks and predictors across neurological disorders...
December 13, 2017: Psychosomatics
https://www.readbyqxmd.com/read/29576435/adults-with-an-epilepsy-history-especially-those-45years-or-older-those-with-lower-family-incomes-and-those-with-a-history-of-hypertension-report-a-history-of-stroke-five-times-as-often-as-adults-without-such-a-history-2010-2013-and-2015-u-s-national-health
#12
EDITORIAL
https://www.readbyqxmd.com/read/29574226/role-of-asic1a-in-a%C3%AE-induced-synaptic-alterations-in-the-hippocampus
#13
D Mango, R Nisticò
Acid-sensing ion channels (ASICs) are widely expressed in the mammalian central nervous system where they play a key role in synaptic transmission and in specific forms of memory. On the other hand, ASICs can be persistently active under pathological conditions contributing to neuronal damage in ischemic stroke, brain trauma, epilepsy and Parkinson's disease. However, to date no experimental evidence has linked ASICs to Alzheimer's disease (AD). Aim of the present work was to investigate, in CA1 pyramidal neurons, the possible involvement of ASIC1a in the Aβ-mediated effect on metabotropic glutamate (mGlu) receptor dependent transmission...
March 21, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29565957/association-of-higher-migraine-risk-among-female-and-younger-chronic-osteomyelitis-patients-evidence-from-a-taiwan-cohort-of-one-million
#14
Jiunn-Horng Chen, Shih-Chi Wu, Chih-Hsin Muo, Chia-Hung Kao, Chun-Hung Tseng, Chon-Haw Tsai
BACKGROUND: Inflammation may trigger migraine development through neurovascular reactions in the brain. Most of the migraine patients, particularly the younger ones, do not have any risk factors for this disease. Hence, we assessed whether chronic osteomyelitis (COM), a chronic inflammatory disease, increases the risk of migraine. OBJECTIVE: We aim to evaluate the risk of migraine among female and middle-age COM patients with a large patient sample. STUDY DESIGN: A retrospective cohort study was conducted in this study...
March 2018: Pain Physician
https://www.readbyqxmd.com/read/29564603/neurological-diseases-and-risk-of-suicide-attempt-a-case-control-study
#15
Astrid Eliasen, Kim Peder Dalhoff, Henrik Horwitz
INTRODUCTION: Neurological diseases have a profound impact on quality of life. We investigated the risk of suicide attempt in ten neurological diseases. METHODS: Case-control study. Cases were identified from the Danish Poison Information Centre database in the period 2006-2013. The prevalence of ten neurological diagnoses was compared with the prevalence in a randomly sampled age- and gender-matched control group. RESULTS: We identified 8974 cases of suicidal attempt and 89,740 controls...
March 21, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29559851/role-of-plant-derived-alkaloids-and-their-mechanism-in-neurodegenerative-disorders
#16
REVIEW
Ghulam Hussain, Azhar Rasul, Haseeb Anwar, Nimra Aziz, Aroona Razzaq, Wei Wei, Muhammad Ali, Jiang Li, Xiaomeng Li
Neurodegenerative diseases are conventionally demarcated as disorders with selective loss of neurons. Conventional as well as newer molecules have been tested but they offer just symptomatic advantages along with abundant side effects. The discovery of more compelling molecules that can halt the pathology of these diseases will be considered as a miracle of present time. Several synthetic compounds are available but they may cause several other health issues. Therefore, natural molecules from the plants and other sources are being discovered to replace available medicines...
2018: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/29549622/targeted-acid-sensing-ion-channel-therapies-for-migraine
#17
REVIEW
Nazia Karsan, Eric B Gonzales, Gregory Dussor
Acid-sensing ion channels (ASICs) are a family of ion channels, consisting of four members; ASIC1 to 4. These channels are sensitive to changes in pH and are expressed throughout the central and peripheral nervous systems-including brain, spinal cord, and sensory ganglia. They have been implicated in a number of neurological conditions such as stroke and cerebral ischemia, traumatic brain injury, and epilepsy, and more recently in migraine. Their expression within areas of interest in the brain in migraine, such as the hypothalamus and PAG, their demonstrated involvement in preclinical models of meningeal afferent signaling, and their role in cortical spreading depression (the electrophysiological correlate of migraine aura), has enhanced research interest into these channels as potential therapeutic targets in migraine...
March 16, 2018: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/29547472/clinical-and-electrographic-correlates-of-bilateral-independent-periodic-discharges
#18
Brin Freund, James J Gugger, Alexandra Reynolds, William O Tatum, Jan Claassen, Peter W Kaplan
PURPOSE: Periodic discharges (PDs) are EEG patterns denoting brain dysfunction and ictal tendency. Their exact meaning regarding etiology and outcomes is not well known. In particular, bilateral independent PDs (BIPDs) are poorly described. METHODS: We performed a retrospective, multicenter study evaluating neuroimaging, epileptic, clinical, and EEG correlates of BIPDs. RESULTS: Twenty-five patients studied with a mean Glasgow Coma Scale 6...
March 15, 2018: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
https://www.readbyqxmd.com/read/29524710/technical-modification-of-amygdalo-hippocampectomy-in-temporal-lobe-epilepsy-surgery-to-further-reduce-severe-neurological-complications-a-clinical-anatomical-study
#19
Karl Roessler, Burkhard S Kasper, Roland Coras, Soheil Arinrad, Michael Scholz, Hajo H Hamer, Ingmar Blümcke, Michael Buchfelder
BACKGROUND: Temporal lobe resection (TLR) including amygdalohippocampectomy (AHE) is the most frequent performed procedure in epilepsy surgery. Owing to the close anatomic relationship of the mesial temporal structures and the midbrain and choroidal fissure, the incidence of severe complications, such as postoperative stroke, is as high as 2.5%. METHODS: We developed a modification of the classical technique for AHE that involves entering the choroidal fissure early via the anterior part of the frontomesial temporal horn cleft to identify the crus cerebri, posterior cerebri artery, and oculomotor nerve...
March 7, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29504292/current-clinical-applications-of-diffusion-tensor-imaging-in-neurological-disorders
#20
REVIEW
Woo Suk Tae, Byung Joo Ham, Sung Bom Pyun, Shin Hyuk Kang, Byung Jo Kim
Diffusion-tensor imaging (DTI) is a noninvasive medical imaging tool used to investigate the structure of white matter. The signal contrast in DTI is generated by differences in the Brownian motion of the water molecules in brain tissue. Postprocessed DTI scalars can be used to evaluate changes in the brain tissue caused by disease, disease progression, and treatment responses, which has led to an enormous amount of interest in DTI in clinical research. This review article provides insights into DTI scalars and the biological background of DTI as a relatively new neuroimaging modality...
February 28, 2018: Journal of Clinical Neurology
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